TWI496586B - Modified composite microparticle, manufacturing method therepf and sunblock formulation thereof - Google Patents

Description

Modified composite microparticles, method for producing the same, and sunscreen formula thereof

The present invention relates to a modified composite microparticle, a method for producing the same, and a sunscreen formulation thereof, and more particularly to a process for modifying and granulating a fungal plant to form inorganic particles on the surface of the modified composite microparticle. The modified composite fine particles having an uneven surface structure are obtained, and the modified composite fine particles added to the sunscreen emulsion to have the effect of full-band UV absorption, a method for producing the same, and a sunscreen formulation thereof can be applied.

As the ozone layer becomes thinner and the ultraviolet radiation increases, prolonged exposure to sunlight can cause skin to darken and form sunburn, accelerate the rate of skin aging, and in severe cases, produce the same blisters as burns. Therefore, sunscreen products are indispensable to modern people.

At present, the sunscreen agents generally used are chemically synthesized organic sunscreen agents, and physical sunscreen powders such as titanium dioxide (TiO ₂ ) or zinc oxide (ZnO) are added, but they are all likely to cause dry skin or after light reaction. The shortcomings caused by free radicals cause skin aging, and when the human skin is damaged by ultraviolet radiation, if chemical sunscreen is used, it will cause serious adverse reactions. Therefore, the safety of sunscreen materials is high, and the general requirements are high. Sunscreen products have limited functions and do not block all UV rays of different wavelengths in sunlight, so there is an urgent need for sunscreen ingredients with good safety performance.

In addition, the current cosmetics industry uses natural materials as the substrate as one of the most potential development technologies, and in order to prevent the adverse effects of ultraviolet rays on the skin, there are sunscreen cosmetic materials that are combined with ultraviolet absorbers or UV-resistant natural plant powders. It is used, for example, to add a Tremella polysaccharide extract to a sunscreen, which has an excellent moisturizing effect.

However, in the prior art, the natural plant is subjected to ultrafine particle treatment to be added to the cosmetic, and although the dispersibility during the preparation can be improved, the function of the polymer compound is lowered, and if the natural extract itself is not dissolved in the hydrophobic solvent, It is difficult to prepare when it is made into an oily cosmetic. Therefore, in order to improve this problem, it is necessary to further change the process method of the natural plant powder material by reforming the granulation process to form the modified composite particles.

In view of the above problems of the prior art, the object of the present invention is to provide a modified composite microparticle, a manufacturing method thereof and a sunscreen formulation thereof, to solve the function of the conventional ultrafine particle treatment to reduce the natural plant extract, and to add to the oily sunscreen. The problem of uneven dispersion in the emulsion is caused.

According to the purpose of the present invention, an improved composite microparticle comprising a plant extracting particle and an inorganic particle is proposed. The inorganic particles are formed on the surface of the plant extract particles, and the inorganic particles may have a particle diameter of between 20 and 1000 nm.

Preferably, the modified composite microparticles can be obtained by heating a natural plant to extract a plant initial extract and filtering, adding a modified solution and mixing uniformly, and collecting a precipitate by a centrifuge to precipitate The product was prepared by freeze-drying, grinding, and pulverization.

Preferably, the natural plant can be a fungal plant comprising Tremella or black fungus.

Preferably, the inorganic particles may be any one of zinc oxide, calcium oxide, magnesium oxide or The minerals of the above combination.

Preferably, the particle size of the plant extract particles may be between 1 and 100 μm.

According to the object of the present invention, a method for manufacturing modified composite microparticles is further provided, which comprises the steps of: heating a natural plant for a predetermined time to extract a plant initial extract; filtering the plant initial extract through a mesh sieve to Obtaining a filtered plant extract; adding a modified solution to the filtered plant extract, and stirring at a stirring temperature to form a modified plant mixture; collecting the modified plant mixture by a centrifuge a precipitate; and the precipitate is freeze-dried, and the precipitate is ground and pulverized to obtain a modified composite particle having one inorganic particle formed on the surface.

Preferably, the modified solution may comprise a cationic mixed solution, and the cationic mixed solution may comprise sodium (Na), calcium (Ca), potassium (K), magnesium (Mg), zinc (Zn), copper (Cu). Any or a combination of the above.

Preferably, the weight percentage of the filtered plant extract and the cation mixed solution may be 0.1 to 50 wt% and 2 to 50 wt%, respectively.

Preferably, the inorganic particles may be minerals comprising any one or a combination of zinc oxide, calcium oxide, magnesium oxide.

Preferably, the inorganic particles have a particle size of between 20 and 1000 nm.

Preferably, the modified composite microparticle further comprises a plant extracting particle formed on the surface of the plant extracting particle, and the particle size of the plant extracting particle may be between 1 and 100 μm.

Preferably, the natural plant can be a fungal plant comprising Tremella or black fungus.

According to the purpose of the present invention, there is further proposed a sunscreen formulation which is a modified composite microparticle as described above.

According to the object of the present invention, there is further proposed a sunscreen formulation which is a modified composite microparticle produced by the above-described method for producing modified composite microparticles.

In view of the above, the modified composite microparticles of the present invention, methods of making the same, and sunscreen formulations thereof, may have one or more of the following advantages:

(1) The modified composite microparticles, the method for producing the same, and the sunscreen preparation thereof can be modified and granulated by the natural plant extract to form modified composite microparticles having inorganic particles on the surface, thereby modifying the composite microparticles. The surface exhibits an irregular structure to increase the full-band UV absorption effect, thereby improving the problem of reduced efficacy of the conventional ultrafine particle treated plant particles added to the cosmetic.

(2) The present invention can be modified and granulated to form modified composite microparticles having a micronized size and uniformly dispersed in an oily sunscreen lotion. It solves the problem of the condensation of the sunscreen particles and increases the adhesion of the sunscreen lotion to the skin.

100‧‧‧Inorganic particles

S21~S25‧‧‧Steps

Fig. 1 is a flow chart showing a method of producing modified composite fine particles of the present invention.

Fig. 2 is a chart showing the absorption spectrum of the modified composite particles of the present invention against UV light.

Fig. 3A is a first image view of the modified composite microparticles of the present invention.

Figure 3B is a second image of the modified composite microparticles of the present invention.

For the benefit of the examiner to understand the features, contents and advantages of the invention and its capabilities The present invention will be described in detail with reference to the accompanying drawings, and the description of the embodiments thereof will be described below, and the drawings are used for the purpose of illustration and description, and are not necessarily true Proportion and precise configuration, so the scope of the attached schema and the configuration relationship should not be interpreted and limited in the actual implementation scope of the invention.

Hereinafter, the modified composite microparticles according to the present invention, the method for producing the same, and the sunscreen formulation thereof will be described with reference to the related drawings. For the sake of understanding, the same components in the following embodiments are denoted by the same reference numerals.

Please refer to FIG. 1 , which is a flow chart of a method for producing modified composite particles of the present invention. The method of natural plant upgrading granulation comprises the following steps: First, step S21: heating a natural plant for a predetermined time to extract a plant initial extract. Next, step S22 is performed: the plant extract is filtered through a mesh screen to obtain a filtered plant extract. Next, in step S23, a modified solution is added to the filtered plant extract, and stirred at a stirring temperature to form a modified plant mixture. Next, in step S24, one of the precipitates in the modified plant mixture is collected by a centrifuge. Finally, in step S25, the precipitate is freeze-dried, and the precipitate is ground and pulverized to obtain a modified composite fine particle having one inorganic particle formed on the surface.

In the above, the natural plant to be subjected to the modified granulation may be a fungal plant which may contain white fungus or black fungus. The upgrading solution may comprise a cationic mixed solution, and the cationic mixing solution may comprise sodium (Na), calcium (Ca), potassium (K), magnesium (Mg), zinc (Zn), copper (Cu) or a combination thereof. The inorganic particles may be minerals containing zinc oxide, calcium oxide, magnesium oxide or the combination thereof, and the above embodiments are not limited thereto.

In the above, the modified composite microparticle further comprises a plant extracting particle, and the inorganic particle is formed on the surface of the plant extracting particle, and the particle size of the plant extracting particle may be between 1 and 100 μm. The particle size of the inorganic particles may range from 20 to 1000 nm. The weight percentage of the filtered plant extract and the cation mixed solution may be 0.1 to 50 wt% and 2 to 50 wt%, respectively.

In the above, the predetermined time of the natural plant heating extraction may be 2 hours, and the method of natural plant extraction may directly use the autoclave heating extraction method, but not limited thereto. The size of the mesh screen for filtering the initial extract of the plant can be 300 mesh. Moreover, the stirring temperature of adding the modified solution to the filtering plant extract may be 10 ° C to 70 ° C, and the stirring time may be 1 to 24 hours. The speed of centrifugation of the modified plant mixture can be 3000 rpm, and the centrifugation time can be 10 minutes.

Please refer to Fig. 2, which is a spectrum of absorption of UV light by the modified composite particles of the present invention. In the figure, the natural plant extract may have an ultraviolet absorption wavelength of 220 nm to 380 nm before the modification, and its absorption value does not exceed 0.6 (Abs). After the process of upgrading and granulating, the modified composite particles are obtained, and the ultraviolet absorption wavelength range can be increased to 200 nm to 400 nm after the modification by the ultraviolet absorption value test, and the broad absorption is observed after the modification. The spectrum is increased and the absorbance is increased above 1 (Abs). The modified composite microparticles of the invention are applied to a sunscreen lotion, so that the sunscreen lotion has the effect of full-band UV absorption.

Please refer to FIGS. 3A-3B, which are the first image view and the second image view of the modified composite microparticles of the present invention. By the above steps, the modified composite particles after modification and granulation can be obtained, and it can be seen by electron microscopy that the plant extract particles before the modification exhibit a smooth structure, as shown in FIG. 3A. The surface of the modified plant extracting particles forms inorganic particles 100, so that the modified composite particles have an uneven micro-nano surface structure. As shown in Figure 3B.

In summary, the modified composite microparticles of the present invention, the method for producing the same, and the sunscreen formulation thereof are modified and granulated by adding a modified solution to the natural plant extract, so that the modified plant extract particles are modified. The surface forms inorganic particles to obtain modified composite particles having an uneven surface structure. In this way, the modified composite particles are applied to the sunscreen lotion, thereby

The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims.

S21~S25‧‧‧Steps

Claims (9)

A modified composite microparticle comprising: a plant extracting particle; and an inorganic particle formed on a surface of the plant extracting particle, wherein the inorganic particle has a particle size of between 20 and 1000 nm; wherein the modifying The composite microparticles are obtained by heating a natural plant to extract a plant initial extract and filtering, adding a modified solution and mixing uniformly, collecting a precipitate by a centrifuge, and freeze-drying the precipitate. Prepared after pulverization; wherein the natural plant is a fungus plant comprising Tremella or black fungus; wherein the modified solution comprises a cation mixed solution, and the cation mixed solution comprises sodium (Na), calcium (Ca And a combination of potassium (K), magnesium (Mg), zinc (Zn), copper (Cu) or a combination thereof; wherein the surface of the modified composite particle is not flatter than the surface of the plant-extracted particle. The modified composite fine particles according to claim 1, wherein the inorganic particles are minerals containing any one or a combination of zinc oxide, calcium oxide, and magnesium oxide. The modified composite microparticles according to claim 1, wherein the plant extracting particles have a particle size ranging from 1 to 100 μm. A method for producing modified composite microparticles, comprising the steps of: heating a natural plant for a predetermined time to extract a a plant initial extract, wherein the natural plant is a fungus plant comprising Tremella or black fungus; the plant extract is filtered through a mesh screen to obtain a filtered plant extract; and a modified solution is added to the filter plant The extract is stirred at a stirring temperature to form a modified plant mixture, wherein the modified solution comprises a cation mixed solution, and the cation mixed solution contains sodium (Na) and calcium (Ca). Any one or a combination of potassium (K), magnesium (Mg), zinc (Zn), copper (Cu); collecting a precipitate in the modified plant mixture by a centrifuge; and depositing the precipitate Freezing and drying, and grinding and pulverizing the precipitate to obtain a modified composite particle having a surface formed with an inorganic particle; wherein the modified composite particle comprises a plant extracting particle formed on the surface of the plant extracting particle The surface of the modified composite particle is made uneven compared to the surface of the plant extract particle. The method for producing modified composite fine particles according to claim 4, wherein the inorganic particles are minerals containing any one or a combination of zinc oxide, calcium oxide, and magnesium oxide. The method for producing modified composite fine particles according to claim 4, wherein the inorganic particles have a particle diameter of between 20 and 1000 nm. The manufacturer of the modified composite microparticles as described in claim 4 of the patent application scope The method wherein the plant extracting particles have a particle size ranging from 1 to 100 μm. A sunscreen formulation comprising one of the modified composite microparticles according to any one of claims 1 to 3. A sunscreen formulation comprising one modified composite microparticles produced by the method for producing modified composite microparticles according to any one of claims 4 to 8.