TWI478747B - Phototherapy and Immediate Detection Device for Photodynamic Therapy and Its Control - Google Patents

Description

Light illumination and instant detection device for photodynamic therapy and control method thereof

The invention relates to a light irradiation and instant detection device and a control method thereof, in particular to a light illumination and instant detection device for photodynamic therapy and a control method thereof.

Photodynamic therapy is a combination of sensitizers and light applied to the disease. It is usually illuminated by a wide-band source (600-750 nm) with a uniform light intensity on a fixed-sized illumination area. The area is usually round or square, but the actual treatment area is usually much smaller than the illumination area, and areas that do not require treatment often require a mask to cover it.

Another method of using an image-guided laser scanning treatment area, such as the "automatic control method for laser light displacement of a laser skin treatment device" disclosed in the Patent No. I283593 of the Republic of China, but also uses light in the method. An equal intensity laser treatment source applies the same intensity of treatment to each treatment area.

The fluorescent diagnostic method developed at present is to fluorinate the sensitizer with a UV light source after applying a light-sensing agent (such as 5-ALA, etc.) in a treatment area and after a certain metabolic time. In the RGB image, the fluorescence image band (red component, corresponding wavelength 580nm~650nm) is independently extracted, and the physician is provided as a reference for diagnosis and treatment to achieve different degrees of treatment for different fluorescent reaction areas.

However, the current photodynamic therapy program still uses one or more sets of instruments of different purposes for treatment and monitoring. These instruments do not have communication channels with each other. The diagnostic or therapeutic information obtained must be judged by the operator. In order to use, the automatic treatment system for information feedback cannot be established, so the following defects exist:

1. Treatment and monitoring separation are different devices, which require continuous monitoring by the full-time staff. Different treatment results may occur due to differences in personal experience, and it is not easy to quantify the treatment process.

2. The laser treatment area is constant and cannot be adapted to changes in the patient's movement during treatment.

3. The treatment area changes cannot be immediately fed back to the treatment unit to adjust the treatment conditions in time.

4. Temperature monitoring requires independent temperature sensing equipment and the results cannot be fed back to the treatment equipment.

Accordingly, it is an object of the present invention to provide a light illumination and instant detection device for photodynamic therapy that simultaneously monitors temperature and position changes in the active area while adjusting operating conditions.

Therefore, the light irradiation and instant detection device of the photodynamic therapy of the present invention comprises a processing unit, an excitation unit electrically connected to the processing unit, an image capturing unit, a laser unit, and a temperature sensing device. unit.

The processing unit includes a host, a display electrically connected to the host, and an operation interface electrically connected to the host.

The excitation unit includes a first light source controller electrically connected to the host, and an excitation light source electrically connected to the first light source controller and capable of illuminating a predetermined area.

The image capturing unit is electrically connected to the host and can receive the reflected light from the predetermined area, and captures the white light image and the fluorescent image of the predetermined area, and overlaps to form an overlapping area and is displayed on the display.

The laser unit includes a second light source controller electrically connected to the host, and a laser light source electrically connected to the second light source controller and capable of illuminating the overlapping area, the second light source controller can control the The laser source illuminates the intensity and position of the overlap region.

The temperature sensing unit is electrically connected to the host and can be used to detect the temperature of the overlapping area.

Another object of the present invention is to provide a control method for the light illumination and instant detection device.

Therefore, the light illumination and instant detection device control method of the photodynamic therapy of the present invention comprises an excitation step, a first image capture step, a second image capture step, a first adjustment step, and a laser light source. The startup step and a temperature sensing step.

The exciting step is to irradiate the predetermined region of the drug to be applied before the sensitizer is applied by the excitation light source of the excitation unit to excite the precursor drug to generate a fluorescence reaction.

The first image capturing step is to capture the white light image of the predetermined area by using the image capturing unit; the second image capturing step is to capture the fluorescent image of the predetermined area by the image capturing unit.

The first adjusting step is to superimpose the white light image and the fluorescent image to form the overlapping area, and adjust the laser light source through the second light source controller to align the laser light source to the overlapping area, and according to the fluorescent light The fluorescence value of the light image is set to an end condition.

The laser light source starting step is to irradiate the laser light source to the overlapping area, and the intensity of the laser light source can be dynamically adjusted according to the intensity of the fluorescent value; the temperature sensing step is detected by the temperature sensing unit The temperature of this overlapping area.

The effect of the invention is that the illumination area of the laser light source can be more accurately positioned through the formation of the overlapping area, and the intensity of the laser light source can be dynamically adjusted according to the intensity of the fluorescence value, and the temperature sensing is matched The unit detects the temperature of the overlapping area, and can more accurately control the illumination condition of the laser source to form a quantitative and objective operation result.

The foregoing and other objects, features, and advantages of the invention are set forth in the <RTIgt;

Referring to FIG. 1, a preferred embodiment of a light-illuminating and instant detecting device 3 for photodynamic therapy of the present invention is used to illuminate a predetermined area 10, and the predetermined area 10 is coated with a precursor drug containing a sensitizer, and The light-emitting and instant detection device 3 includes a processing unit 31, and an excitation unit 32, an image capturing unit 33, and a laser unit 34 electrically connected to the processing unit 31, respectively. And a temperature sensing unit 35. In this embodiment, the prodrug is 5-aminolevulinic acid (5-ALA) or 5-ALA methylesther.

The structure of the light illuminating and detecting device 3 is described below. The processing unit 31 includes a host 311, a display 312 electrically connected to the host 311, and an operation interface 313 electrically connected to the host 311.

The excitation unit 32 includes a first light source controller 321 electrically connected to the host 311, and an excitation light source 322 electrically connected to the first light source controller 321 and capable of illuminating the predetermined area 10, wherein the excitation light source 322 is ultraviolet light, which can stimulate the fluorescent reaction of the precursor drug.

The image capturing unit 33 includes a color image sensor 331 electrically connected to the host 311, an image capturing lens 332 disposed on the color image sensor 331, and an optical image sensor electrically connected to the color image sensor. Image processor 333 of 331. The reflected light from the predetermined area 10 is received by the image capturing lens 332, and the white light image and the fluorescent image of the predetermined area 10 are captured by the color image sensor 331, and the white light image and the white light are imaged by the image processor 333. The light images overlap to form an overlap region 20 for display on the display 312.

The principle of the color image sensor 331 capturing the fluorescent image is described here. The image captured by the color image sensor 331 is represented by the gray intensity of the individual components of the three primary colors of RGB (red, green, and blue). Color, if the sensitizer is excited to emit red fluorescence when the excitation light source 322 is activated, the red component in the captured image is the fluorescent image excited by the sensitizer, and the image processor 333 is fluorescent. The grayscale values of the image and the white light image are added together.

The laser unit 34 includes a second light source controller 341 electrically connected to the host 311, and a laser light source 342 electrically connected to the second light source controller 341 and capable of illuminating the overlap region 20, the second The light source controller 341 can control the intensity and position of the laser light source 342 that is incident on the overlap region 20.

The temperature sensing unit 35 is electrically connected to the host 311 and can be used to detect the temperature of the overlapping region 20, and the temperature sensing unit 35 has a dot region detecting capability or a planar region detecting capability.

Referring to FIG. 1 and FIG. 2, the control method of the light illumination and instant detection device 3 is further described. The control method includes an excitation step 41, a first image capture step 42, a second image capture step 43, and a second image capture step 43. The first adjusting step 44, a laser light source starting step 45, a temperature sensing step 46, a second adjusting step 47, and a statistical step 48.

The excitation step 41 is performed by the operator through the operation interface 313 to control the first light source controller 321 of the excitation unit 32, and the excitation light source 322 is irradiated on the predetermined region 10 to which the drug is applied before the sensitizer is applied to stimulate the precursor drug production. Fluorescent reaction.

The first image capturing step 42 is performed by the color image sensor 331 of the image capturing unit 33 through the image capturing lens 332 to capture the white light image of the predetermined area 10; the second image capturing step 43 is The fluorescent image of the predetermined area 10 is captured in the same manner. Of course, the order of capturing the white light image and the fluorescent image may be reversed or performed simultaneously, and is not limited to the content disclosed in the embodiment.

The first adjustment step 44 is performed on the display 312 by the image processor 333 of the image capturing unit 33 superimposing the white light image and the fluorescent image on an overlap region 20, and the operator views the display on the display 312. The second light source controller 341 of the laser unit 34 is controlled by the operation interface 313, and the laser light source 342 is adjusted to be aligned with the overlap region 20. In addition, it should be specially stated that when the sensitizer is excited by fluorescein alone, all the features of the skin can not be completely revealed, and the white light image can make the characteristics of the skin clearer and more accurately locate the overlapping area. .

The laser light source starting step 45 is to irradiate the laser light source 342 to the overlapping area 20, and perform the pulse scanning or continuous emission of the laser light source 342 according to actual needs, while the laser light source 342 is irradiated. The temperature sensing step 46 detects the temperature of the overlapping region 20 by the temperature sensing unit 35. The overlapping region 20 may be a dot or a surface.

It should be particularly noted that the white light image and the fluorescent image of the predetermined area 10 can be periodically captured during the operation to instantly adjust the illumination position of the laser light source 342, and the intensity of the laser light source 342 can be adjusted according to the firefly. The magnitude of the light value is dynamically adjusted. That is, the present invention guides the irradiation position of the laser light source 342 with the overlapping area 20 of the white light image and the fluorescent image, and uses the fluorescence value as the intensity of the laser light source 342. The variable is controlled, and an end condition is set according to the fluorescence value of the overlap region 20, wherein the end condition is determined according to the actual situation.

In addition, when the temperature sensing unit 35 detects that the temperature of the overlapping area 20 is higher than a set value (for example, 40 ° C), the laser light source 342 can be temporarily stopped, and the temperature is restored to be lower than the setting. After the value, the laser light source 342 startup step can be automatically performed again.

After the above steps are completed, the second adjusting step 47 is performed. The second adjusting step 47 re-forms a new overlapping area 20 with the new white light image and the fluorescent image, and determines whether the fluorescent value of the overlapping area 20 is If the fluorescence value is less than the end condition, the laser light source 342 is no longer activated. When the fluorescence value is greater than or equal to the end condition, the laser light source 342 is restarted again until the fluorescence value is less than the End condition.

After the end of the entire process, the statistical step 48 is performed to count the sum of the total energy emitted by the laser source 342 and the time of activation, thereby recording and analyzing the entire operation.

Through the above device and control method, the present invention has the following advantages in practical use:

(1) Modular design, easy to integrate various information:

The excitation unit 32, the image capturing unit 33, the laser unit 34, and the temperature sensing unit 35 are electrically connected to the processing unit 31, so that the entire device forms a modular design, and the information obtained by each unit is It can be transmitted to the processing unit 31 for integration analysis.

(2) Instant information feedback and adjustment operating conditions:

The method of capturing the white light image and the fluorescent image by timing, and matching the temperature monitoring function of the temperature sensing unit 35, the information during the operation is fed back to the processing unit 31 and displayed on the display 312. The operator is reminded to achieve the effect of instantly adjusting the illumination position and intensity of the laser source 342.

(3) It is easy to quantify various information and provide more precise operating conditions:

As described above, since the information obtained by each unit can be integrated into the processing unit 31, not only can the information be integrated and the operation result can be quantified, but the operation conditions can be more accurately ensured, and the units can be prevented from being different by different personnel. The difference in the operation.

Referring to FIG. 3 , the image capturing unit 33 may further include a monochrome image sensor 334 electrically connected to the host 311 of the processing unit 31 , and used in conjunction with the monochrome image sensor 334 . A beam splitter 335 and a filter 336. Through the beam splitter 335 and the filter 336, a specific wavelength of light (such as red fluorescent light) is passed through the sensitizing agent in the precursor drug to enter the monochrome image sensor 334, and the fluorescent image is separately presented. To get a higher resolution.

In summary, the information of the present invention can be integrated and analyzed by the processing unit 31, and then the laser unit 34 is guided to operate, and the illumination condition of the laser light source 342 can be more accurately controlled to form a quantitative and The objective result of the operation is indeed the object of the present invention.

The above is only the preferred embodiment of the present invention, and the scope of the invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All remain within the scope of the invention patent.

10. . . Scheduled area

20. . . Overlapping area

3. . . Light illumination and instant detection device

31. . . Processing unit

311. . . Host

312. . . monitor

313. . . Operation interface

32. . . Excitation unit

321. . . First light source controller

322. . . Excitation source

33. . . Image capture unit

331. . . Color image sensor

332. . . Image capture lens

333. . . Image processor

334. . . Monochrome image sensor

335. . . Beam splitter

336. . . Filter

34. . . Laser unit

341. . . Second light source controller

342. . . Laser source

35. . . Temperature sensing unit

41. . . Excitation step

42. . . First image capture step

43. . . Second image capture step

44. . . First adjustment step

45. . . Laser light source startup steps

46. . . Temperature sensing step

47. . . Second adjustment step

48. . . Statistical step

1 is a schematic structural view of a system for explaining a preferred embodiment of the light irradiation and instant detection device of the photodynamic therapy of the present invention;

2 is a flow chart showing a preferred embodiment of the light irradiation and instant detection device control method of the photodynamic therapy of the present invention; and

FIG. 3 is a schematic structural view of the system, illustrating another aspect of the light illumination and instant detection device of the photodynamic therapy.

10. . . Scheduled area

20. . . Overlapping area

3. . . Light illumination and instant detection device

31. . . Processing unit

311. . . Host

312. . . monitor

313. . . Operation interface

32. . . Excitation unit

321. . . First light source controller

322. . . Excitation source

33. . . Image capture unit

331. . . Color image sensor

332. . . Image capture lens

333. . . Image processor

34. . . Laser unit

341. . . Second light source controller

342. . . Laser source

35. . . Temperature sensing unit

Claims (10)

A light-irradiation and instant detection device for photodynamic therapy for illuminating a predetermined area, the light illumination and instant detection device comprising: a processing unit comprising a host, a display electrically connected to the host, and a Electrically connected to the operation interface of the host; an excitation unit includes a first light source controller electrically connected to the host, and an excitation light source electrically connected to the first light source controller and capable of illuminating the predetermined area; The image capturing unit is electrically connected to the host and can receive the reflected light from the predetermined area, and captures the white light image and the fluorescent image of the predetermined area, and overlaps to form an overlapping area and is displayed on the display; The firing unit includes a second light source controller electrically connected to the host, and a laser light source electrically connected to the second light source controller and capable of illuminating the overlapping area, the second light source controller capable of controlling the lightning The intensity of the light source is incident on the overlapping area; and a temperature sensing unit electrically connected to the host to detect the temperature of the overlapping area when the temperature is sensed When the temperature detecting element of the overlapping region is higher than a predetermined value, so that the laser light can be irradiated to stop temporarily. The light irradiation and instant detection device of the photodynamic therapy according to claim 1, wherein the predetermined area is a precursor drug containing a sensitizer, and the excitation light source is ultraviolet light, which can excite the precursor drug to generate fluorescence. reaction. The light-irradiation and instant detection device of the photodynamic therapy according to the second aspect of the invention, wherein the image capturing device comprises a color image sensor electrically connected to the host of the processing unit, and a color image sensor is disposed in the color An image taking lens on the image sensor and an image processor electrically connected to the color image sensor. The light-emitting and instant detection device of the photodynamic therapy according to the third aspect of the invention, wherein the image capturing unit further comprises a monochrome image sensor electrically connected to the host of the processing unit, and A beam splitter and a filter used in the monochrome image sensor. The light irradiation and instant detection device of the photodynamic therapy according to the first aspect of the patent application, wherein the temperature sensing unit has a dot-like region detecting capability. The light irradiation and instant detection device of the photodynamic therapy according to the first aspect of the patent application, wherein the temperature sensing unit has a planar region detecting capability. The light irradiation and instant detection device of the photodynamic therapy according to the first aspect of the patent application, wherein the laser light source can perform pulse scanning or continuous emission. A method for controlling a light irradiation and instant detection device for photodynamic therapy according to claim 1 of the patent application, comprising: an excitation step of irradiating an excitation light source of the excitation unit with a predetermined drug before the application of the sensitizer a region for exciting a precursor drug to generate a fluorescent reaction; a first image capturing step for capturing the predetermined portion by the image capturing unit a white image of the predetermined area; a second image capturing step, the image capturing unit captures the fluorescent image of the predetermined area; and a first adjusting step, the white light image and the fluorescent image are overlapped to form the overlapping area, And adjusting, by the second light source controller, the laser light source to align the laser light source to the overlapping area; a laser light source starting step, irradiating the laser light source to the overlapping area, and the laser light source The intensity can be dynamically adjusted according to the intensity of the fluorescent value, and an end condition is set according to the fluorescence value of the overlapping area; and a temperature sensing step is used to detect the temperature of the overlapping area by the temperature sensing unit, when the temperature When the sensing unit detects that the temperature of the overlapping area is higher than a set value, the laser light source can be temporarily stopped. According to the control method of the light irradiation and the instant detection device of the photodynamic therapy according to Item 8 of the patent application, a second adjustment step is further included, a new overlapping area is newly formed, and whether the fluorescence value of the overlapping area is determined is If the fluorescence value is less than the end condition, the laser light source is no longer activated, and when the fluorescence value is greater than or equal to the end condition, the laser light source starting step is repeated again. According to the control method of the light irradiation and the instant detection device of the photodynamic therapy according to claim 8 or 9, the method further comprises a statistical step of counting the total energy emitted by the laser light source and the sum of the startup time.