TWI415644B - Medicament delivery device - Google Patents

Abstract

The present invention relates to a medicament delivery device comprising a housing having a proximal and a distal section formed by a first housing part and a second housing part; a first compartment formed inside said proximal housing section for accommodating a medicament container, which medicament container comprises at least one stopper; a circle-segment-formed second compartment formed inside said distal housing section for accommodating a drive unit capable of moving said at least one stopper in the proximal direction within said medicament container; wherein the drive unit comprises a support wheel rotatably arranged inside said second compartment, said support wheel comprises a central tubular hub on which a first and a second washer-formed disks are fixedly attached, parallel to each other and interconnected by an abutment cross-wall; a plurality of spherical members arranged in a row between the abutment wall and adjacent said stopper, said plurality of spherical members being guided in a channel formed by the inner periphery of the circle-segment-formed second compartment, by the outer periphery of said central tubular hub, by the inner side surfaces of the washer-formed disks and by a guide member; a pre-tensioned clock spring coaxially arranged within said central tubular hub having an outer end connected to said central tubular hub and an inner end connected to a one-direction-rotatable tubular hub coaxially arranged around a shaft fixedly attached to the first housing part; and an activation member interactively connected to said first washer-formed disk by co-acting hold-and-release means such that when said activation member is in a non-depressed position said support wheel and said clock spring are held in at least one tensioned and static state and when said activation member is moved from the non-depressed position to a depressed position, said clock spring and thereby said support wheel are released from their at least one tensioned and static state such that said plurality of spherical members are forced against said at least one stopper.

Description

Drug delivery device

The present invention relates to a drug delivery device, particularly a drug delivery device that is light, simple, and convenient to operate.

Many drug delivery devices have been developed over the past few years. These devices are characterized by varying degrees of functionality and automation, such as drug component mixing, pre-flushing, drug delivery, puncture, and the like, to name a few.

Many devices have a slim plunger rod that acts on a stopper in a drug container. The plunger rod is pushed toward the end by a driving force member (usually a helical compression spring). This structure means that the device becomes long due to the spring acting on the end of the plunger rod, and is a so-called pen type syringe.

In many cases, due to the shape relationship, the user does not want to use a thin pen type syringe, and some attempts have been made to shorten the length of the syringe. An alternative design is disclosed in document WO 2009/047247, the hydraulic spring being parallel to the plunger rod and having a shorter and more square appearance. Another solution is disclosed in document US 6,585,699. The plunger rod is made of a flexible material (having a thread on one side that cooperates with a blunt gear).

The primary object of the present invention is to provide a drug delivery device that is lightweight and has many features.

This goal can be accomplished by the characteristics of a separate item of patent scope. A more preferred embodiment of the invention is the subject matter of the scope of this patent.

According to a primary aspect of the present invention, a drug delivery device includes a housing having a proximal end and a distal end portion formed by a first outer casing portion and a second outer casing portion; a first compartment in the proximal outer casing a portion formed to receive a drug container, the drug container comprising at least one stopper; a second compartment formed by a circle formed in the end housing portion to accommodate a driving device capable of moving the at least one stopper in a proximal direction The drug container comprises: a support wheel rotatably located in the second compartment, the support wheel comprising a central tubular hub having a first and a second washer-like disk fixedly attached to each other And interconnected by an adjacent intersecting wall; a plurality of spherical members are continuously disposed between the adjacent intersecting wall and the adjacent cork, the plurality of spherical members being introduced into the inner circumference of the second compartment formed by the circle, the center An outer circumference of the tubular hub, an inner surface of the washer-like disc, and a passage formed by a guiding member; a pre-applied tensioning clock spring is coaxially disposed in the central tubular hub, An outer end is coupled to the central tubular hub, and an inner end is coupled to a one-way rotating tubular hub, coaxially attached to the first outer casing portion coaxially about a shaft; and an actuating member is actuated by a pick and place device Interactingly coupled to the first washer-like disc such that when the actuating member is in the non-depressed position, the support wheel and the clock spring remain in at least one tension and rest state, and when the actuating member is unpressed When the position is moved to the depressed position, the clock spring and thus the support wheel are released from their at least one tension and rest state such that the plurality of spherical members press the at least one stopper.

According to another aspect of the present invention, the pick and place device has a first lateral projection disposed on a proximally facing tongue of the activation member, and a first groove on a side of the first washer-shaped disk, The first trench includes at least a first radiating groove portion and at least a first common circumferential groove portion, wherein each of the first radiating groove portions is followed by a first common circumferential groove portion, so that When the first lateral protrusion is located in the at least one first radiating groove portion, the support wheel and the clock spring are maintained in at least one of a tension and a stationary state, and when the starting member is moved from the non-depressed position to the pressure at the proximal end In the lower position, the first lateral projection moves from the at least one first radiation toward the groove portion into the first common circumferential groove portion, whereby the clock spring and the support wheel are released from at least one of the tension and rest states.

According to another aspect of the invention, each of the first common circumferential groove portions has a predetermined predetermined length that corresponds to a predetermined dose.

According to another aspect of the present invention, the first trenches are respectively provided with at least two first radiation directions and at least two first common circumferential groove portions, wherein the first portion of the first common circumferential groove portion is prepared An increasing radius for forcing the actuating member to move toward the end (moving from the depressed position to the undepressed position), and wherein the last portion of the first common circumferential groove portion is provided with a fixed radius, whereby The activation member is supported in a depressed position to indicate that the device has been used.

According to another aspect of the present invention, the first groove is provided with a plurality of first radiation directions and a first common circumferential groove portion to provide multiple drug dose delivery, wherein the first common circumferential groove portion An incremental radius is provided to force the activation member to move toward the end (from the depressed position to the undepressed position), and wherein the first portion of the first common circumferential groove portion A fixed radius is provided whereby the activation member is supported in the depressed position, indicating that the device has been used.

According to another aspect of the invention, the medicament container comprises two compartments, each compartment comprising a substance and separated by a movable stopper and an end stopper, wherein the first common circumferential groove portion makes the clock The spring forces the support wheel and a number of spherical members to perform material mixing.

According to another aspect of the present invention, the apparatus further includes a starter wheel that is interactively coupled to the actuating member by a common action of locking and releasing the device such that when the actuating member is in the non-depressed position, the lock and loose The opening device moves from the non-depressed position to the depressed position to lock the activation member.

According to another aspect of the invention, the starter wheel includes a disc-shaped member abutting the support wheel and a gripping device to rotate the starter wheel.

According to another aspect of the invention, the locking and releasing device is a second lateral projection (located on the proximal end of the activation member toward the tongue) and a second groove (on the side of the disc-shaped member), The second groove includes a second common circumferential portion and at least one second radial groove portion such that when the second lateral projection is located in the second common circumferential portion, the activation member is locked, and when When the two lateral projections are placed in front of one of the second radiation-facing groove portions, the activation member is moved from the non-depressed position to the depressed position.

According to another aspect of the present invention, the first washer-shaped disk is provided with a third lateral protrusion acting on the current interrupter of the disk-shaped member, such that when the support wheel is rotated by the clock spring, the third The lateral projection moves the starter wheel from a position at which the actuating member is movable (from a non-depressed position to a depressed position) to a position where the actuating member is locked.

The present invention has a number of advantages, as a lightweight device is achieved by the use of a plurality of spherical members (driven by a lightweight clock spring) rather than a generally rigid elongated plunger rod, particularly in comparison to many conventional drug delivery devices. length.

Still another advantage is that the use of a groove in the support wheel cooperates with at least one protrusion of the activation member whereby the support wheel can be locked and a portion of the length of the groove conforms to a particular dose. In this way, it is possible to vary the dose by varying the length of the groove. It is also possible to provide multiple doses, such as multiple dose devices, in the same drug container by adding a grooved portion around the support wheel.

Also, when a dual chamber drug container is used, the first portion of the continuous groove portion is used to operate the mixing. The groove portion can be additionally arranged such that the activation member is locked in a particular position, meaning that the device is used and should be discarded. Therefore, it is impossible for the user to confuse the new and used devices.

These and other advantages of the invention will be apparent from the description and appended claims.

In the current application, the terminus means the drug delivery device or the member that is furthest from the user at the time of injection. Correspondingly, the proximal side means the drug delivery device or the member closest to the user at the time of injection.

1 to 10 indicate that a first entity includes the present invention, and FIGS. 11 to 14 indicate a second entity. The same elements of the first entity have the same reference numerals, and the modified elements of the first entity have an ellipsis added to the reference numerals. in.

The drug delivery device of the present invention comprises a housing having a housing The end portion and the end portion are formed by a first outer casing portion 10 and a second outer casing portion 12. Reasonably, other designs are also possible within the present invention.

The drug delivery device further includes a first compartment 14 formed in the proximal housing portion for receiving a drug container 16, 16', wherein a proximal end of the drug container 16, 16' is joined to the proximal end of the housing a neck portion 18, and wherein the drug container includes at least one stopper 22, 24; and a second compartment formed by a circle formed in the end housing portion to accommodate a driving body capable of moving the at least one bottle in a proximal direction Plugged into the drug container 16, 16'. A drug delivery member (not labeled) can be attached to the neck 18 of the outer casing.

The driving body comprises: a supporting wheel 30, 30' rotatably located in the second compartment, the supporting wheel comprising a central tubular hub 32 having a first 34, 34' and a second 36 washer-like disc fixed thereon Attached and parallel to one another, and interconnected by an adjacent intersecting wall 38; a plurality of spherical members 64 are continuously disposed adjacent the intersecting wall 38 and the adjacent corks 22, 24, the plurality of spherical members 64 being introduced by the circle The inner circumference of the second compartment, the outer circumference of the central tubular hub 32, the inner surface of the washer-like disc, and the passage 28 formed by a guiding member 92; a pre-applied tension spring 52 is coaxially disposed The central tubular hub 32 has an outer end coupled to the central tubular hub 32 and an inner end coupled to a one-way rotating tubular hub 54 that is fixedly attached to the first outer casing portion 10 coaxially about a shaft 58; An activation member 80 is interactively coupled to the first washer-like disc 34 by a cooperating pick and place device such that the support wheel and the clock spring remain at least one tension when the actuating member is in the non-depressed position And quiet a state in which the clock spring and the support wheel are released from at least one of their tension and rest states when the actuating member is moved from the non-depressed position to the depressed position, such that the plurality of spherical members 64 squeeze the At least one stopper 24 .

As shown in Fig. 1b and Fig. 2, the hub 32 is provided with a slit 50 in which the outer end of the clock spring 52 is tightly fixed. The inner end of the clock spring 52 is attached to the slit 56 of the one-way rotating tubular hub 54. One end of the one-way rotating tubular hub 54 is provided with an inclined wedge surface 60 (Fig. 3) cooperating with a corresponding inclined wedge surface 62 (Fig. 2) on the inner surface of the end portion of the first outer casing portion 10 surrounding the shaft 58. The function of the wedge faces 60, 62 will be explained as follows. The other end of the one-way rotating tubular hub 54 is provided with a top portion 63.

The pick and place device (shown in Figures b, 3, and 11b) is disposed as a first lateral projection 86 on the proximal tongue 82 of the actuating member 80 (Fig. 3), and a first groove Located on the side of the first washer-shaped disk 34, 34', the first groove includes at least one first radiating groove portion 42, 46 (Fig. 1b), 42', 46', 47 (Fig. 11 b), and at least a first common circumferential groove portion 44, 48 (Fig. 1b), 44', 45, 48' (Fig. 11b), where each first radial groove portion is followed by a first common circumferential groove portion 44, 48, 44', 45, 48' (as shown in FIGS. 1 b and 11 b) such that the first lateral projection 86 is located in at least one first radial groove The support wheel and the clock spring are maintained in at least one tension and rest state, and the first lateral protrusion 86 is from at least one when the activation member 80 is moved from the non-depressed position to the depressed position toward the proximal end. The first radiation moves into the first common circumferential groove portion toward the groove portion, whereby the clock spring and the support wheel are at least One gives tension and the static state is released. Further, each of the first common circumferential groove portions 44, 48, 44', 45, 48' has a specific predetermined length corresponding to the preset dose. Reasonably speaking, other pick and place designs are also possible within the present invention.

In the first entity (as shown in FIG. 1b), the first groove is continuously provided with at least two first radiations 42, 46 and at least two first common circumferences 44, 48 toward the groove portion, where the first common The first portion of the circumferential groove portion 44 is provided with an increasing radius to force the actuating member 80 to move toward the end (moving from the depressed position to the non-depressed position), and here the first common circumferential groove portion The last portion of 48 is provided with a fixed radius whereby the activation member is supported in the depressed position to indicate that the device has been used.

In the second entity (as shown in FIG. 11b), the first groove is successively provided with a plurality of first radiation directions 42', 46', 47 and a first common circumferential direction 44', 45, 48' groove portion. Multiple drug dose delivery is provided, where the first portion of the first common circumferential groove portion 44', 45 is provided with an increasing radius to force the activation member 80 to move toward the end (moving from the depressed position to the non-pressed position). The lower position), and here the last portion of the first common circumferential groove portion 48' is provided with a fixed radius, whereby the actuating member is supported in the depressed position, indicating that the device has been used.

In the first entity, the drug container 16 is of the so-called dual chamber type (Fig. 1c), where the drug container comprises two compartments 19, 20, each compartment comprising a substance and being moved by a stopper 22 and a The end stoppers 24 are separated, where the first common circumferential groove portion 44 causes the clock spring 52 to force the support wheel 30 and the plurality of spherical members 64 to perform material mixing.

The drug delivery device further includes a activation wheel 66, 66' that is interactively coupled to the activation member 80 by cooperating with the grasping device such that when the activation member is in the non-depressed position, the retrieval device locks the The starting member 80 (moves from a non-depressed position to a depressed position).

The starter wheels 66, 66' include a disc-shaped member 66, 66' adjacent the support wheel 30, 30' and a gripping device 68 (for rotating the starter wheel). The gripping device 68 extends through a circular opening 13 toward the end of the second outer casing portion 12.

The pick and place device (shown in Figures 2, 3, and 11a) is a second lateral projection 84 located on the proximal end of the actuating member 80 toward the tongue 82, and a second groove is located in the disc member 69, On the side of 69', the second groove includes a second common circumferential portion 74, 74' and at least a second radial groove portion 76, 78, 76', 78', 79, so that when the second When the lateral projection 84 is placed on the second common circumferential portion 74, 74', the activation member 80 is locked, and when the second lateral projection is placed in one of the second radial projection portions 76, 78 At the front end of 76', 78', 79, the activation member 80 can be moved from the non-depressed position to the depressed position.

As shown in Figs. 1a and 12, the first washer-shaped discs 34, 34' are provided with a third lateral projection 70 acting on the current interrupter 72 of the disc member 69, 69' so that the support When the wheel 30, 30' is rotated by the clock spring 52, the third lateral protrusion 70 moves the starter wheel 66, 66' from the position where the actuating member 80 can be moved (from the non-depressed position to the depressed position). ) Move to the position where the starting member is locked.

The device is perfectly equipped with a drug container when it is delivered to the user. 16, 16' in the first compartment of the outer casing. Further, the clock spring 52 has been previously biased during assembly (when the support wheels 30, 30' are fixedly supported, the tool 63 is rotated by the tool 63 to rotate the one-way rotating tubular hub 54). Due to the relationship of the wedge faces 60, 62 of the one-way rotating tubular hub 54 and the first outer casing portion 10, the one-way rotating tubular hub 54 can only be rotated in a single direction, and the reverse direction is locked, whereby the clock spring 52 maintains the imparting Tension state. The support wheels 30, 30' are held by a first lateral projection 86 (located within the first radial groove portion 42, 42' of the first groove). Further, an end second lateral protrusion 85 on the side of the tongue portion 82 of the actuating member 80 is located in the groove 88 on the inner surface of the second outer casing portion 12 (Fig. 3). In the non-depressed position, the actuating member 80 is locked by the actuating wheels 66, 66' having a position to place the second lateral projection 84 of the actuating member in the disc member 69 of the starter wheel 66, 66', In one end of the second common circumferential portion 74, 74' of the second groove on 69' (as shown in Figures aa and 11b).

The first physical device includes a dual chamber container that functions as follows. To activate the drug delivery device and the mixing elements within the drug container, the starter wheel 66 is rotated clockwise by manually operating the gripping device 68 until the third lateral projection 70 of the first washer-like disk 34 abuts the circumference of the disk member 69. Up to the edge of the current interrupter 72 (Figure 4). The second radiating groove portion 76 of the second groove on the disk member 69 of the starter wheel 66 now coincides with the second lateral projection 84 of the actuating member (Fig. 4). This position can be displayed by a window or opening 90 in the second outer casing portion 12 of the device (Fig. 2), or a particular state can be displayed by indicating or different colors on one side of the disk member 69 of the starter wheel 66. For example: a green indicates that the device is ready to start.

The activation member 80 can now be depressed to begin the mixing operation (Fig. 5). This causes the second lateral projection 84 of the activation member to move along the second radiation toward the groove portion 76 of the second groove on the disk member 69 of the starter wheel 66, and the first on the other side of the tongue 82 The horizontal projection 86 moves toward the first groove of the first groove on the first washer-shaped disk 34 along the support wheel (the state in which the tension is maintained by the clock spring 52) toward the groove portion 42. When the first lateral protrusion 86 reaches the first radiation-facing groove portion 42 (Fig. 5c) and enters the first common circumferential groove portion 44, the support wheel 30 can be freely biased by the force of the pre-compressed clock spring 52. Rotate clockwise. Adjacent intersecting wall 38 of support wheel 30 then acts on spherical member 64 and is then guided in passage 28 toward end stopper 24. The end stoppers 24 are thus moved toward the proximal stoppers 22 so that they are moved to the channel position established between the two compartments 19, 20, thereby performing material mixing (Fig. 8c).

During the movement of the support wheel, the first lateral projection 86 of the activation member 80 moves along the first normal circumferential groove portion 44, whereby the activation member is forced to push out toward the distal end (Fig. 6 and Fig. 7) until the first transverse The projections 86 hit the end faces of the first radiation groove portions 46, thereby stopping the movement of the support wheels. During the movement of the support wheel, the third lateral projection 70 also moves along the current interrupter 72 until the third lateral projection 70 hits the end face of the current interrupter (Fig. 7a). The extent and position of the interruption is related to the end face of the first common circumferential groove portion 44, causing the starter wheel 66 to be moved further such that the actuating member 80 is located at the second normal circumferential portion 74 by the second lateral projection 84. It is locked again because it is pressed down (Figure 8a).

In order to perform drug delivery now, the device must be activated again. start The moving wheel 66 is again manually rotated clockwise, whereby the second lateral projection 84 moves into the second normal circumferential portion 74 until the second lateral projection 84 and the second groove on the disk member 69 of the starter wheel 66 The second radiation is equal to the groove portion 78 (Fig. 9). The starting member 80 can now be depressed. This can be indicated by a suitable indicator or color in the window 90.

The proximal end of the device is located at the injection site, and if the injection needle is a delivery member, the injection site can serve as a puncture site. The puncture is done manually. Thereafter, the actuating member 80 is depressed, whereby the second lateral projection 84 moves into the second radiating groove portion 78 (Fig. 10a), so that the first lateral projection 86 also moves into the first washer-like disc of the support wheel 30. The first radiating groove portion 46 of the first groove on the 34 until the first lateral protrusion 86 moves to the first common circumferential groove portion 48 (Fig. 10b), so that the support wheel 30 is borrowed from the clock spring 52 Force to start rotating in a clockwise direction. Movement of the support wheel again causes the spherical member 64 to move proximally, pushing the stoppers 22, 24 toward the front end to push the medicament out through the drug delivery member. When the stopper reaches the proximal end position in the drug container, the movement of the support wheel 30 is stopped (Fig. 10c). Since the first common circumferential groove portion 48 is provided with a fixed radius, the actuating member is fixed in the depressed position (Fig. 10b), indicating that the device has been used and can be discarded. Therefore there is no risk of confusing users with used and unused devices.

The second physical device includes a single chamber container 16' containing a plurality of medicaments to be delivered, which will operate as follows. A drug delivery member is attached to the proximal neck of the housing. To deliver a dose of medication, the starter wheel 66' is rotated clockwise by manual operation of the gripping device 68 until the third lateral projection 70 of the first washer-like disc 34' abuts a flow interrupted around the circumference of the disc member 69'. Up to the edge of the device 72. The second radiating groove portion 76' of the second groove on the disk member 69' of the starting wheel 66' now coincides with the second lateral projection 84 of the actuating member. This position may be indicated by a window or opening 90 in the second outer casing portion 12 of the device, or may be indicated by a side of the disc member 69' of the actuating wheel 66' with an indication or a different color. For example: a green indicates that the device is ready to start.

The proximal end of the device is located at the injection site, and if the injection needle is a delivery member, the injection site can serve as a puncture site. The puncture is done manually. The activation member 80 can now be depressed to begin the delivery operation. This causes the second lateral projection 84 of the activation member to move along the second radiation toward the groove portion 76' of the second groove on the disk member 69' of the starter wheel 66', and on the other side of the tongue 82 The first lateral protrusion 86 moves along the first radiation toward the groove portion 42' of the first groove on the first washer-shaped disk 34' of the support wheel 30' (fixed to the tension state by the clock spring 52) . When the first lateral protrusion 86 reaches the first radiation-facing groove portion 42' and enters the first normal circumferential groove portion 44' (FIG. 13), the support wheel 30' can be biased by the force of the pre-compressed clock spring 52. And free to rotate in a clockwise direction. The adjacent intersecting wall 38 of the support wheel 30' then acts on the spherical member 64 and is then guided in the passage 28 toward the end stopper 24. The end stopper 24 is thus moved proximally so that a dose of the drug is discharged through the drug delivery member. The drug delivery member is now removed.

During the movement of the support wheel, the first lateral projection 86 of the actuating member 80 moves along the first normal circumferential groove portion 44', whereby the actuating member is forced to move out toward the end (Fig. 14a and Fig. 14b) Until the first lateral protrusion 86 hits the end face of the first radiation toward the groove portion 46', thereby stopping the support The movement of the wheel. During the movement of the support wheel, the third lateral projection 70 also moves along the current interrupter 72 until the third lateral projection 70 hits the end face of the current interrupter (Fig. 14a). The extent and position of the current interruption is related to the end face of the first common circumferential groove portion 44', causing the starter wheel 66' to be moved further such that the actuating member 80' is located at the second normal circumference by the second lateral projection 84. It is locked in the portion 74' again by being pressed (Fig. 15a).

When the device is continuously used for a period of time, a new drug delivery member is attached, and the above operation is performed. As seen in the design of the groove portion of the first groove on the first washer-like disk 34 of the support wheel 30' and the groove portion of the second groove on the disk member 69 of the support wheel 66, three doses are seen. Will be delivered, and after the last dose is delivered, the protrusion 86 will enter the first normal circumferential groove portion 48' of the first groove on the first washer-like disk 34 of the support wheel, whereby the activation member is Locked, indicating that the drug container is empty. It will be apparent from the above that the groove portion on the first washer-like disk 34' of the support wheel 30' and the groove portion on the disk member 69' of the starter wheel 66' can be modified to provide more dose of medicament. delivery.

The embodiments and the drawings described above are only to be considered as limiting examples of the invention, and the invention may be modified in many ways within the scope of the patent.

10‧‧‧First outer casing

12‧‧‧Second outer casing

14‧‧‧First compartment

16‧‧‧ drug containers

19‧‧ ‧ compartment

20‧‧ ‧ compartment

22‧‧‧Removable stopper

24‧‧‧End stopper

28‧‧‧ Pipes

30‧‧‧Support wheel

32‧‧‧ center tubular hub

34‧‧‧First washer-shaped disc

36‧‧‧Second washer-shaped disc

42‧‧‧First radiation to the groove

44‧‧‧First common circumferential groove

45‧‧‧First common circumferential groove

46‧‧‧First radiation to the groove

47‧‧‧First radiation to the groove

48‧‧‧First common circumferential groove

52‧‧‧clock spring

54‧‧‧One-way rotating tubular hub

58‧‧‧Axis

64‧‧‧Balls

66‧‧‧Starting wheel

68‧‧‧ grip device

69‧‧‧Disc member

70‧‧‧ Third lateral protrusion

72‧‧‧ current interrupter

74‧‧‧Second ordinary circumferential section

76‧‧‧Second radiation to the groove

78‧‧‧Second radiation to the groove

80‧‧‧Starting components

82‧‧‧Feet

84‧‧‧Second lateral protrusion

85‧‧‧End second lateral protrusion

92‧‧‧Guide members

DETAILED DESCRIPTION OF THE INVENTION In the following detailed description, reference is made to the drawings in which: FIG. 1a is a side view of a first entity diagram according to the present invention, and the outer casing portion of the device is removed for clarity.

Figure 1b is a side view of the entity diagram according to Figure 1 a, removing the starter wheel to Clearly presented.

Figure 1c is a cross-sectional side view of the apparatus according to Figure 1a.

Figure 2 is an exploded view of the device according to Figure 1a.

Figure 3 is an exploded view of the device according to Figure 1a, and Figure 2 is rotated 180°.

Figures 4 to 10 are side views of different functional positions of the device according to Figure 1a.

Figure 11a is a side view of a second entity diagram in accordance with the present invention with the outer casing portion of the removal device clearly shown.

Figure 11b is a side view of the entity diagram of Figure 11a, with the launch wheel removed for clarity.

Figure 11 c is a cross-sectional side view of the apparatus according to Figure 11a.

Figures 12 to 15 are side views of different functional positions of the device according to Figure 11.

10‧‧‧First outer casing

16‧‧‧ drug containers

18‧‧‧ neck

66‧‧‧Starting wheel

68‧‧‧ grip device

70‧‧‧ Third lateral protrusion

72‧‧‧ current interrupter

74‧‧‧Second ordinary circumferential section

76‧‧‧Second radiation to the groove

78‧‧‧Second radiation to the groove

80‧‧‧Starting components

82‧‧‧Feet

84‧‧‧Second lateral protrusion

85‧‧‧End second lateral protrusion

Claims (10)

The drug delivery device comprises: a housing having a proximal end and a distal end portion formed by a first outer casing portion (10) and a second outer casing portion (12); a first compartment (14) is inside the proximal outer casing portion Formed to contain a drug container (16, 16'), the drug container comprising at least one stopper (24); a second compartment formed by a circle formed in the end housing portion to accommodate a drive device movable in a proximal direction The at least one stopper (24) is in the drug container; characterized in that the driving device comprises: a support wheel (30, 30') rotatably located in the second compartment, the support wheel comprising a central tubular hub (32) a first (34, 34') and a second (36) washer-like disc are fixedly attached to each other, parallel to each other and connected to each other by an adjacent intersecting wall (38); a plurality of spherical members (64) are continuously arranged Adjacent the intersecting wall and the adjacent cork, the plurality of spherical members are introduced into the inner circumference of the second compartment by the circle, the outer circumference of the central tubular hub, the inner surface of the washer-shaped disc, and a guiding member (92) in the formed channel (28); a pre-tensioned clock spring (52) is placed coaxially The central tubular hub has an outer end connected to the outer circumference of the central tubular hub, and an inner end connected to a one-way rotating tubular hub (54) coaxially attached to the first shaft (58) for fixed attachment to the first An outer casing portion; and an actuating member (80) are interactively coupled to the first washer-like disk by a cooperating pick and place device such that when the actuating member is in a non-depressed position At the time of setting, the support wheel and the clock spring are maintained in at least one tension and rest state, and when the actuating member is moved from the non-depressed position to the depressed position, the clock spring and the support wheel are at least one of them The tension and rest are released so that the plurality of spherical members squeeze the at least one stopper. The drug delivery device of claim 1, wherein the pick and place device is a first lateral projection (86) disposed on the proximally facing tongue (82) of the activation member (80), and a first trench on a side of the first washer-shaped disk (34, 34'), the first trench including at least one first radiating groove portion (42, 46, 42', 46', 47) And at least one first common circumferential groove portion (44, 48, 44', 45, 48'), wherein each first radial groove portion is followed by a first common circumferential groove portion (44, 48) , 44', 45, 48'), such that when the first lateral protrusion (86) is located in the at least one first radial groove portion, the support wheel and the clock spring are maintained in at least one of a tension and a stationary state, and When the actuating member (80) is moved from the non-depressed position to the depressed position, the first lateral protrusion (86) moves from the at least one first radiation toward the groove portion into the first common circumferential groove portion, thereby The clock spring and the support wheel are released from at least one of the tension and rest states. According to the drug delivery device of claim 2, each of the first common circumferential groove portions (44, 48, 44', 45, 48') has a specific predetermined length corresponding to the preset dose. The drug delivery device of claim 3, wherein the first groove is provided with at least two first radiations (42, 46) and at least two first common circumferential (44, 48) grooves, respectively. Here, the first portion of the first common circumferential groove portion (44) is provided with an increasing radius to force the starting structure The member (80) moves toward the end (from the depressed position to the non-depressed position), and here the last portion of the first common circumferential groove portion (84) is provided with a fixed radius, whereby the actuating member is supported In the depressed position, the device has been used. The drug delivery device of claim 3, wherein the first groove is provided with a plurality of first radiation directions (42', 46', 47) and a first common circumferential direction (44', 45, 48' The groove portion provides multiple drug dose delivery, wherein the first portion of the first common circumferential groove portion (44', 45) is provided with an increasing radius to force the activation member (80) to move toward the end (moving from the depressed position to the non-depressed position), and wherein the last portion of the first common circumferential groove portion (48') is provided with a fixed radius, whereby the actuating member is supported in the depressed position, Indicates that the device has been used. The drug delivery device of claim 4, wherein the drug container comprises two compartments (19, 20), each compartment comprising a substance, and by a removable stopper (22) and an end stopper ( 24) is separated, where the first common circumferential groove portion (44) causes the clock spring (52) to force the support wheel (30) and the plurality of spherical members (64) to perform material mixing. According to the drug delivery device of claims 2 to 6, the device further includes a starter wheel (66, 66') that is interactively coupled to the activation member (80) by a common action with the locking and releasing device. The locking and releasing means are moved from the non-depressed position to the depressed position to lock the activation member (80) when the activation member is in the non-depressed position. The drug delivery device of claim 7, wherein the activation wheel (66, 66') includes a disc-shaped member (69, 69') adjacent to the support wheel (30, 30') and a grasping device (68) to rotate the starter wheel. The drug delivery device of claim 8 wherein the pick and place device is a second lateral projection (84) located on the proximal end of the activation member (80) toward the tongue (82), and a second The groove is located on a side of the disk member (69, 69'), the second groove includes a second common circumferential portion (74, 74') and at least a second radial groove portion (76, 78, 76', 78', 79), such that when the second lateral projection (84) is placed in the second normal circumferential portion (74, 74'), the activation member (80) is locked, and When the second lateral projection (84) is placed at the front end of one of the second radiating grooves (76, 78, 76', 78', 79), the actuating member (80) can be depressed Move the position to the depressed position. The drug delivery device of claim 9, wherein the first gasket-like disk (34, 34') has a third lateral protrusion (70) acting on the disk-shaped member (69, 69') The current interrupter (72) such that when the support wheel (30, 30') is rotated by the clock spring (52), the third lateral protrusion (70) the starting wheel (66, 66') The position from which the starting member (80) is moved (moving from the non-depressing position to the depressed position) is moved to a position where the starting member (80) is locked.