TWI415640B - Medicament delivery device - Google Patents

Abstract

The present invention relates to a medicament delivery device it is characterised by medicament delivery device comprising a generally tubular housing having opposite proximal and distal ends, wherein the housing is provided with a coaxial tubular sleeve extending from its distal end towards the proximal end; a generally tubular medicament delivery member shield coaxially and slidably arranged within the housing, wherein a proximal portion of the tubular medicament delivery member shield protrudes from the proximal end of the housing; a medicament container provided with a medicament delivery member, a chamber containing a medicament, and an axial movable piston; drive means comprising a plunger rod having opposite proximal and distal ends, and a force spring means, wherein the proximal end of the plunger rod is in contact with the piston; wherein the device further comprises a medicament container holder coaxially arranged to the drive means and capable of supporting the medicament container; wherein the medicament container holder comprises a first locking means releasibly connected to corresponding locking means on the coaxial tubular sleeve forming a first locking engagement for holding the medicament container holder in an initial state against a force from the drive means, wherein the medicament delivery member shield is capable of releasing said first locking engagement when the medicament delivery member shield is pressed against a medicament delivery site, whereby said drive means forces said medicament container holder a certain predetermined distance towards the proximal end of the device; and a second locking means surrounded by the coaxial tubular sleeve and releasibly connected to corresponding locking means on the plunger rod forming a second locking engagement for preventing the piston to be affected by the force from the drive means until said medicament container holder has moved the certain predetermined distance.

Description

Drug delivery device

The present invention relates to a drug delivery device having a drug container holder; in particular, a drug container holder capable of preventing injury due to breakage of the drug container.

There are many drug delivery devices on the market that have a drug container therein, typically in a container holder that is designed to hold a drug container.

Many drug delivery devices are equipped with a number of automatic triggering functions, such as: puncture, injection, retraction, protection after delivery of the drug delivery member, etc. (only a few are listed).

Many of these functions require a large number of parts to make the device more complicated, and also require an operational appearance. Even if such functions are automatic, some users still find it difficult. There are also some ideas about the interaction between different parts, the need to manage the tolerance chain, which can be complicated when many parts interact.

As a result, many devices reduce the number of parts as much as possible to reduce functional complexity and reduce tolerance chains. The number of parts used and applied to the drug should also be reduced as much as possible to provide clear and concise operation.

Furthermore, depending on the condition, different drugs should have the most appropriate injection depth for good efficacy. Therefore, leakage before the needle reaches the expected injection depth may lose the expected efficacy. Therefore, the injection does not start during the puncture, otherwise a spring acts on a plunger rod to perform the puncture and injection. On the other hand, two springs are needed, first puncture and then injection.

Advances in drug delivery devices with a specific number of automatic functions space.

The primary object of the present invention is to remedy the shortcomings of today's drug delivery devices.

This goal can be accomplished by the characteristics of a separate item of patent scope. A more preferred embodiment of the invention is the subject matter of the scope of this patent.

According to a primary aspect of the present invention, a drug delivery device includes an elongated outer casing having opposite proximal ends and ends, wherein the outer casing is provided with a coaxial tubular sleeve extending from the distal end to the proximal end; a common tubular drug delivery member shield Coaxially and slidably disposed within the outer casing, wherein the proximal end of the tubular drug delivery member shield projects from the proximal end of the outer casing; a drug container is provided with a drug delivery member, a cavity including a drug and a shaft a moving piston; the driving device includes a plunger rod having opposite proximal ends and ends, and a force spring device at a proximal end of the plunger rod in contact with the piston; wherein the device further includes a drug container holder coaxially Disposed on the driving device and capable of supporting the drug container; the drug container holder comprises a first locking device detachably connected with the corresponding locking device on the coaxial tubular sleeve to form a first locking engagement, and the driving device is inclined in an initial state The force is used to support the drug container, where the first lock engagement can be released when the drug delivery member shield is pressed against the drug delivery, whereby the drive forces the device The drug container holder is moved to the proximal end of the device by a predetermined distance; and a second locking device is surrounded by the coaxial tubular sleeve and releasably coupled with the corresponding locking device on the plunger rod to form a second lock engagement for avoiding The piston is affected by the force of the drive until the drug container holder has moved a certain distance.

According to another aspect of the invention, the first locking device comprises an outwardly extending ledge that is placed on a resilient arm on the outer plane of the drug container holder, and the locking device (the opening on the proximal end of the coaxial tubular sleeve) ) has a common shape with the boom to allow the ledge to fit into the opening.

According to another aspect of the present invention, the second locking device includes an elastic tongue extending toward the distal end having an inwardly facing frame, wherein the corresponding locking means is a circumferential groove on the plunger rod, having a common shape with the arm frame To allow the ledge to fit into the groove.

According to another aspect of the present invention, when the drug container holder is in an initial state, the plunger rod is fitted into the groove of the plunger rod by the inward wall of the tongue, and is surrounded by the coaxial tubular sleeve and prevents the tongue It flexes outward in a radial direction and is supported against the force of the drive.

According to another aspect of the invention, the second lock engagement is released after the first lock engagement is released and when the second lock device reaches the proximal end of the coaxial tubular sleeve.

According to another aspect of the invention, the medicament container holder further includes a first stop means for cooperating with a corresponding stop means on the inner surface of the outer casing when the drug container holder is moved toward the proximal end of the drug delivery device.

According to another aspect of the present invention, the drug delivery device further includes a drug delivery member shield force spring device disposed between the proximal wall of the drug container holder and the annular recess at the proximal end of the drug delivery member shield to serve as a drug When the delivery member shield is removed from the drug delivery, the drug delivery member shield is pushed toward the proximal end of the device.

According to another aspect of the present invention, the drug delivery device further includes a drug delivery member shield lock device that is placed on the inner surface of the outer casing for the drug delivery member shield After being pushed toward the proximal end of the device, it cooperates with the end annulus of the drug delivery member shield and thus prevents the drug delivery member shield from being moved toward the end of the device.

According to another aspect of the present invention, the drug delivery device further includes a drug delivery member shield lock device disposed on the lock sleeve coaxially and fixedly disposed within the outer casing and coaxially surrounding the drug container holder.

According to another aspect of the invention, the medicament container holder further includes a second stop means for cooperating with a corresponding stop means on the drug delivery member shield.

According to another aspect of the present invention, the drug delivery device further includes a damping member located in the drug container holder capable of buffering the force applied to the drug container when the drug container holder is released from the initial state.

According to another aspect of the present invention, the damping member is capable of pressing the distal end face of the drug container against the proximal end surface of the drug container holder.

The invention has many advantages. Since the drug container holder is designed with first and second locking devices, it is possible to use a spring device for the puncture and subsequent injection. This greatly reduces the number of parts compared to conventional units.

This in turn makes the unit light and has a short tolerance chain, allowing different parts to provide reliable functionality. Another advantage is that the device is activated only by pressing against the drug delivery site, whereby the first puncture is activated without affecting the drug in the drug container, and then the injection is initiated when the puncture is applied to the desired depth . It can therefore be determined that the injection will only occur when the needle reaches a full depth.

Furthermore, in order to determine the risk of reducing damage to the drug container during the startup process, a damping device is used to reduce the force applied to the drug container. Furthermore, the use of a buffer device allows the drug container to be properly placed, the reference surface of the drug container The (end face) leans against the wall fixed to the drug container, allowing the tolerance chain of the device to be well controlled.

These and other advantages of the invention will be apparent from the description and appended claims.

In the current application, the terminus means the drug delivery device or the member that is furthest from the user at the time of injection. Similarly, proximal refers to the end of the drug delivery device or member that is closest to the user at the time of injection.

The drug delivery device of the present invention includes, in Fig. 2, a generally elongated outer casing 10 having opposite proximal ends and ends, wherein the outer casing is provided with a coaxial tubular sleeve 60 extending proximally from the distal end; a common tubular drug delivery member shield 12 Coaxially and slidably disposed within the outer casing 10, wherein the proximal end of the tubular drug delivery member shield projects from the proximal end of the outer casing 10; a drug container 26 (eg, a syringe) is provided with a drug delivery member 24 ( For example, an injection needle, a cavity includes a drug and an axially movable piston 27; the driving device includes a plunger rod 54 having opposite proximal ends and ends, and a force spring device 56 at which the plunger rod The proximal end is in contact with the piston 27; a drug container holder is coaxially disposed on the drive means and can support the drug container 26; a releasable shield 16 is coaxially disposed on the circumferential surface of the end of the outer casing 10.

Furthermore, in order to determine the risk of reducing damage to the drug container during the startup process, a damping device is used to reduce the force applied to the drug container. Further, the use of a cushioning device allows the drug container to be properly placed, and the reference surface (end surface) of the drug container is placed against the wall fixed to the drug container, so that the tolerance chain of the device is well controlled.

The proximal end of the drug delivery member shield is provided with an annular member 14 (Fig. 2), the distal circumferential region of the drug delivery member shield is provided with a rectangular opening 15 (Fig. 2), and the protective sleeve 16 is provided with a coaxial sleeve member 18, including The inwardly projecting hook 20 engages the resilient sheath 22 where it surrounds the drug delivery member (Fig. 1).

The drug container holder 28 is slidable within the housing and has a directional end extension including a first tubular portion 40. The tubular portion is provided with a first locking device 42, 44 releasably coupled with a corresponding locking device 61 on the coaxial tubular sleeve 60 to form a first locking engagement that supports the drug container against the force of the driving device 54, 56 in an initial state. Here, the first lock engagement can be released when the drug delivery member shield 12 is pressed against the drug delivery, whereby the drive means 54, 56 forces the drug container holder 28 to move a predetermined distance toward the proximal end of the device.

The extension then becomes two end-to-end second locking means 48, 50 surrounded by a coaxial tubular sleeve 60. The second locking device is releasably coupled to the corresponding locking device 52 on the plunger rod 54 to form a second locking engagement for preventing the piston 27 (eg, rubber stopper) from being affected by the force of the driving device until the drug container holder 28 After moving a certain distance.

The first locking device includes an outwardly extending ledge 44 disposed on a resilient arm 42 on the outer surface of the drug container holder 28, and the corresponding locking device (opening 61 on the proximal end of the coaxial tubular sleeve 60) and The boom 44 has a common shape to allow the ledge 44 to fit into the opening 61.

The second locking device includes an elastic tongue 48 extending toward the distal end having an inwardly facing frame 50, wherein the corresponding locking device is a circumferential groove 52 in the plunger rod having a common shape for the wall frame 50 to be closed Into the groove 52.

The drug container holder 28 in turn includes a first stop means 47 and a second stop means 46 on the tubular portion 40. The first stop means 47 cooperates with the stop means 11 opposite the inner face of the outer casing when the drug container holder is moved towards the proximal end of the drug delivery device. The second stop means 46 cooperates with the stop means 13 on the opposite side of the drug delivery member shield 12.

The plunger rod 54 is hollow and has a force spring device 56 therein, such as a compression spring. A compression spring 56 is placed and pulled between the inner proximal end of the plunger rod 54 and the transverse end wall and the inner end of the coaxial tubular sleeve 60 and the transverse end wall. A compression rod 58 is included in the compression spring 56. When the drug container holder is in the initial state, the inward wall shelf 50 of the elastic tongue 48 of the drug container holder 28 is supported in the groove 52 by the inner surface of the coaxial tubular sleeve 60 to prevent the tongue 48 from being emitted. The shape is outwardly flexed, and thus the plunger rod can be supported against the force of the compression spring to be fired. A current interrupter 62 is also provided on the proximal side of the coaxial tubular sleeve 60. Furthermore, the coaxial tubular sleeve 60 is part of the outer casing or a separate portion is attached to the end of the outer casing 10.

The device further includes a drug delivery member sheath force spring 30 located at the proximal end of the proximal end wall 32 of the drug container holder and the proximal end of the drug delivery member sheath 12 Between the recesses, the drug delivery member shield is urged toward the proximal end of the device as the drug delivery member shield is removed from the drug delivery.

The device in turn includes a drug delivery member shield lock device 68 that is placed on the inner surface of the outer casing 10 to cooperate with the end annular surface of the drug delivery member shield after the drug delivery member shield is pushed toward the proximal end of the device, and thus prevents The drug delivery member shield is moved toward the end of the device. It is envisioned that the drug delivery member shield lock device 68 is placed on the lock sleeve 64, coaxially and fixedly disposed within the outer casing 10, and coaxially surrounding the drug container holder 28.

2, the drug delivery member shield lock device 68 is an arm that is resilient and projects inwardly toward the proximal end, on the side of the lock sleeve 64. This arm 68 is in contact with the longitudinal ridge 70 on the proximal end of the drug container holder 28 through the rectangular opening 15 of the drug delivery member sheath 12. A current interrupter 72 is provided at the end of the lock sleeve 68.

The end of the drug container 26 is provided with a radially outward flange 36 which is mounted to a current interrupter 37 in the side wall of the container holder 28.

The device also includes a damping member 38 disposed on the drug container holder 28 that is capable of cushioning the force applied to the drug container 26 when the drug container holder is released from the initial state. The damping member 38 has a U-shape and is capable of pressing the distal end surface of the drug container against the proximal end surface of the drug container holder 28. This arrangement aids in the tolerance chain management of the device, as the end face of the drug container has been fully certified by the container manufacturer and can therefore be considered a reference surface.

The device operates in the following manner. When the device is delivered to the user, the drug container 26 is placed within the drug holder and the drug container holder is placed within the housing. The drug delivery member 24 is covered by a sheath 22 and a shield 16. medicine The container holder 28 is suitably supported by the outwardly extending ledge 44 of the resilient arm 42 engaging the opening 61 in the proximal region of the coaxial tubular sleeve 60. Furthermore, the plunger rod 54 is suitably biased against the force of the compression spring 56 by the inwardly facing frame 50 of the resilient tongue 48 of the drug holder 28 (the tongue 48 is engaged with the recess 52 of the plunger) Supported. Therefore, the drug container holder is in an initial state and is ready for use. The drug delivery member sheath 12 is placed against the drug delivery member by a second stop device 46 (wedge protrusion) on the tubular portion 40 in contact with a corresponding stop device 13 (the end side of the rectangular opening 15 of the drug delivery member sheath 12). The force of the spring 30 is applied to avoid moving to the proximal end.

When drug delivery is completed, the proximal end of the drug delivery member sheath is pressed against the drug delivery. The drug delivery member sheath 12 is advanced into the outer casing 10 (moving toward the distal end) whereby the distal end of the drug delivery member sheath 12 and the outwardly extending ledge 44 of the resilient arm 42 of the drug container holder 28 are proximally inclined. contact. This contact causes the resilient arms 42 of the drug container holder 28 to move radially inwardly, whereby the outwardly extending ledge 44 is removed from the side of the opening 61. The drug container holder 28 is now free to move and is biased by the force of the compression spring 56 (acting between the inner proximal end of the plunger rod 54 and the transverse end wall and between the inner end of the coaxial tubular sleeve 60 and the transverse end wall) The device pushes a specific preset distance at the near end. However, due to the attachment of the circumferential groove 52 to the inner ledge 50, the plunger rod 54 remains stationary relative to the drug container holder 28. Movement of the drug container holder 28 toward the proximal end of the device causes the drug delivery member to enter the drug delivery site, such as causing the injection needle 24 to puncture into the injection site. At the same time, the drug delivery member sheath spring 30 is compressed (Fig. 3). The movement of the drug container holder 28 (e.g., puncture) is blocked by the first stop device 47 (drug container support) A ledge on the shelf contacts the corresponding ledge 11 on the inner surface of the housing). The damping member reduces the risk of damaging the drug container when the drug container holder 28 is moved (eg, puncture).

When the drug container holder 28 is moved a predetermined distance toward the proximal end of the device and the puncture is stopped, the end of the tongue 48 of the drug container holder 28 reaches the current interrupter 62 in the proximal end of the coaxial tubular sheath 60. The tongue 48 can move radially outwardly and release the plunger rod 54.

The plunger rod 54 is forced in the proximal direction by the force of the compression spring 56, causing the piston 27 to be in the proximal direction, so that the drug is delivered via the drug delivery member 24. Movement of the drug container holder 28 toward the proximal end of the device causes the drug delivery member shield lock device 68 to ignore the second stop device 46 of the drug container holder 28.

When drug delivery is completed and the device is removed from the drug delivery, the drug delivery member sheath 12 is free to move proximally against the force of the drug delivery member sheath spring 30. The drug delivery member sheath 12 thus surrounds the drug delivery member 24 and cooperates with the drug delivery member sheath by the drug delivery member shield lock device 68 to prevent removal toward the tip. This avoids accidental needle sticks (Figure 4). The device can now be discarded.

The embodiments and the drawings described above are only to be considered as limiting examples of the invention, and the invention may be modified in many ways within the scope of the patent.

10‧‧‧ Shell

11‧‧‧stop device

12‧‧‧Drug delivery member shield

13‧‧‧stop device

15‧‧‧ Rectangular opening

26‧‧‧ drug containers

27‧‧‧Piston

28‧‧‧ drug container holder

30‧‧‧Drug conveying member sheathing force spring device

32‧‧‧ Near wall

34‧‧‧ annular recess

38‧‧‧damage member

42‧‧‧Flexible arm

44‧‧‧Outwardly extending ledge

46‧‧‧second stop device

47‧‧‧First stop device

48‧‧‧Flexible tongue

50‧‧‧inward arm

52‧‧‧around grooves

54‧‧‧ plunger rod

56‧‧‧Compression spring

60‧‧‧ coaxial sleeve

61‧‧‧ openings

64‧‧‧ lock sets

68‧‧‧ drug delivery member sheath lock device

DETAILED DESCRIPTION OF THE INVENTION In the following detailed description, reference is made to the drawings in which: FIG. 1a, b is a cross-sectional view according to the invention.

Figure 2 is an exploded view according to Figure 1.

Figures 3a, b are cross-sectional views according to Figure 1 after the drug delivery member has been moved into the drug delivery site.

Figures 4a, b are cross-sectional views according to Figure 1 after drug delivery is completed.

10‧‧‧ Shell

12‧‧‧Drug delivery member shield

13‧‧‧stop device

14‧‧‧rings

15‧‧‧ Rectangular opening

16‧‧‧ protective cover

22‧‧‧sheath

26‧‧‧ drug containers

28‧‧‧ drug container holder

30‧‧‧Drug conveying member sheathing force spring device

36‧‧‧Flange

37‧‧‧Cuts

38‧‧‧damage member

40‧‧‧Tube

42‧‧‧Flexible arm

44‧‧‧Outwardly extending ledge

46‧‧‧second stop device

47‧‧‧First stop device

48‧‧‧Flexible tongue

50‧‧‧inward arm

52‧‧‧around grooves

54‧‧‧ plunger rod

56‧‧‧Compression spring

58‧‧‧guides

60‧‧‧ coaxial sleeve

61‧‧‧ openings

62‧‧‧Cuts

64‧‧‧ lock sets

68‧‧‧ drug delivery member sheath lock device

70‧‧‧ longitudinal ridge

72‧‧‧ current interrupter

Claims (12)

A drug delivery device comprising: an elongated outer casing (10) having opposite proximal ends and ends, wherein the outer casing is provided with a coaxial tubular sleeve (60) extending from the distal end to the proximal end; a common tubular drug delivery member shield (12) coaxial And slidably disposed within the outer casing (10), wherein a proximal end portion of the tubular drug delivery member shield projects from a proximal end of the outer casing (10); a drug container (26) is provided with a drug delivery member (24), The chamber includes a medicament and an axially moveable piston (27); the drive means includes a plunger rod (54) having opposite proximal ends and ends, and a force spring means (56) wherein the plunger rod is proximal The end is in contact with the piston (27); characterized in that the device further comprises a drug container holder (28) coaxially disposed on the driving device and capable of supporting the drug container (26); wherein the drug container holder (28) comprises: a first The locking device (42, 44) is releasably coupled with the corresponding locking device (61) on the coaxial tubular sleeve (60) to form a first locking engagement, which is used in the initial state against the force of the driving device (54, 56) To support the drug container, wherein the drug delivery member shield (12) can be pressed against the drug delivery site Release the first lock engagement whereby the drive means (54, 56) forces the drug container holder (28) to move a predetermined distance toward the proximal end of the device; a second lock device (48, 50) is coaxially sleeved (60) wraparound and releasably coupled with a corresponding locking device (52) on the plunger rod (54) to form a second locking engagement for preventing the piston (27) from being affected by the force of the driving device until the drug container The bracket (28) moves after a certain distance. The drug delivery device of claim 1, wherein the first lock device comprises an outwardly extending ledge (44) disposed on a resilient arm (42) on an outer plane of the drug container holder (28), and wherein The locking device (the opening (61) on the proximal end of the coaxial tubular sleeve (60)) has a shape in common with the boom (44) to allow the ledge (44) to fit into the opening (61). The drug delivery device of claim 1 or 2, wherein the second locking device comprises an elastic tongue (48) extending toward the distal end having an inwardly facing shelf (50), wherein the corresponding locking device is a plunger A circumferential groove (52) on the stem has a common shape with the boom (50) to allow the ledge to fit into the recess (52). The drug delivery device of claim 3, wherein in the initial state, the plunger rod (54) is fitted into the recess of the plunger rod (54) by the inward wall bracket (50) of the tongue (48). The groove (52), and surrounded by the coaxial tubular sleeve (60), prevents the tongue (48) from flexing outwardly and is supported against the force of the drive means (54, 56). The drug delivery device of claim 1 or 2, wherein the second lock engagement is after the first lock engagement is released, and when the second lock device (48, 50) reaches the proximal end of the coaxial tubular sleeve (60) , was released. The drug delivery device of claim 1 or 2, wherein the drug container holder (28) further comprises a first stopping device (47), and when the drug container holder is moved toward the proximal end of the drug delivery device, the first stopping device The corresponding stop devices (11) on the inside of the housing cooperate. The drug delivery device of claim 1 or 2, wherein the device further comprises a drug delivery member shield force spring device (30) Placed between the proximal wall (32) of the drug container holder and the annular recess (34) at the proximal end of the drug delivery member shield (12) to remove the drug delivery member shield from the drug delivery site The drug delivery member shield is pushed toward the proximal end of the device. The drug delivery device of claim 7, wherein the device further comprises a drug delivery member shield lock device (68) disposed on the inner surface of the outer casing (10) such that the drug delivery member shield is pushed toward the proximal end of the device Cooperating with the end annulus of the drug delivery member shield, and thus preventing the drug delivery member shield from being moved toward the end of the device. The drug delivery device of claim 7, wherein the device further comprises a drug delivery member shield lock device (68) disposed on the lock sleeve (64) coaxially and fixedly disposed within the outer casing (10) And surrounding the drug container holder (28) coaxially. The drug delivery device of claim 1 or 2, wherein the drug container holder (28) further comprises a second stopping device (46) cooperating with a corresponding stopping device (13) on the drug delivery member shield (12) . A drug delivery device according to claim 1 or 2, wherein the device further comprises a damping member (38) located in the drug container holder (28) capable of buffering the drug when the drug container holder is released from the initial state The force on the container (26). The drug delivery device of claim 11, wherein the damping member (38) is capable of pressing a distal end surface of the drug container against a proximal end surface of the drug container holder (26).