TWI392629B - Inserts for multiple component containers - Google Patents

Inserts for multiple component containers Download PDF

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Publication number
TWI392629B
TWI392629B TW95139619A TW95139619A TWI392629B TW I392629 B TWI392629 B TW I392629B TW 95139619 A TW95139619 A TW 95139619A TW 95139619 A TW95139619 A TW 95139619A TW I392629 B TWI392629 B TW I392629B
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TW
Taiwan
Prior art keywords
insert
container
opening
reservoir
movable portion
Prior art date
Application number
TW95139619A
Other languages
Chinese (zh)
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TW200728162A (en
Inventor
Eric Smith Matthew
Mondszein Karl
Original Assignee
Carbonite Corp
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Publication of TW200728162A publication Critical patent/TW200728162A/en
Application granted granted Critical
Publication of TWI392629B publication Critical patent/TWI392629B/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/24Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/70Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for
    • B65D85/72Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for for edible or potable liquids, semiliquids, or plastic or pasty materials
    • B65D85/73Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for for edible or potable liquids, semiliquids, or plastic or pasty materials with means specially adapted for effervescing the liquids, e.g. for forming bubbles or beer head
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/24Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2857Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by displacing or removing an element enclosing it
    • B65D51/2864Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by displacing or removing an element enclosing it the element being a plug or like element closing a passage between the auxiliary container and the main container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216Rigid containers disposed one within the other
    • B65D81/3222Rigid containers disposed one within the other with additional means facilitating admixture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2037Separating means having valve means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Check Valves (AREA)
  • Package Specialized In Special Use (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)

Description

多組件容器插入物 Multi-component container insert

本發明係關於包含原本分開儲存但於容器打開時混合的二或多不同物質或成分的多成分容器插入物。 The present invention is directed to a multi-component container insert comprising two or more different substances or ingredients that were originally stored separately but mixed when the container is opened.

特別是二成分的多成分容器在有許多領域中被使用或是合乎所欲的。因此,有一些藥物組合係以混合物型態服用,但以混合物的型態長期而言卻是不穩定的。這樣一種組合的成分因此被分開儲存且僅在服用前不久才混合。於此例中,此二成分通常係液態,但成分之一亦有可能是固體或粉末狀。這種容器亦可能發現使用於食品市場,特別是供飲料使用者。因此,舉例來說,有關罐裝或瓶裝的儲藏啤酒與萊姆汁,僅在飲用此飲料不久前將萊姆汁混入儲藏啤酒中是合乎所欲的。 In particular, two-component multi-component containers are used or are desirable in many fields. Therefore, some drug combinations are taken in a mixture form, but the form of the mixture is unstable in the long term. Such a combined component is therefore stored separately and mixed only shortly before administration. In this case, the two components are usually liquid, but one of the components may also be solid or powdery. Such containers may also find use in the food market, particularly for beverage users. Thus, for example, for canned or bottled lager beer and lime juice, it is desirable to mix the lime juice into the lager beer just before drinking the beverage.

本發明的目標即是提供一種簡單又廉價並且當容器被打開時,能使容器中的一種成分可靠地自動地與容器中第二種成分混合的多成分容器的插入物。 It is an object of the present invention to provide an insert that is simple and inexpensive and that enables a component of the container to be reliably and automatically mixed with the second component of the container when the container is opened.

根據本發明,多成分容器的插入物包括一具有由一用以與一密封元件嚙合的外圍邊緣定義的開口的貯藏器,使用中的貯藏器與密封元件定義一實質密封空間,該貯藏器包括一固定部位及一可動部位,該可動部位與固定部位相連並且經由貯藏器內的氣體壓力的動作相對於固定部位係可動的,一射出開口形成於可動部位中,一氣體洩漏路徑供給於貯藏器中,一閥元件連接於固定部位並且與射出開口合作並實質密封它,由其一大於對於貯藏器外部之對於 其內部之氣體壓力的作用導致可動部位相對於固定部位的移動,並且因此導致閥元件移出與射出開口的密閉接觸,其中,貯藏器係一包括一隔膜的單件塑膠鑄件並且可動部位係經由至少二相反方向的環狀折疊線連接於固定部位,相對於貯藏器外部,對於其內部的一較大氣體壓力的作用導致在折疊線周圍的旋轉移動並且因此導致可動部位的移動,以及該閥元件及射出開口共同構成經由其氣體可能流入貯藏器中而不是由其流出之定義氣體洩漏路徑的一單向閥。 In accordance with the present invention, an insert for a multi-component container includes a receptacle having an opening defined by a peripheral edge for engaging a sealing member, the receptacle and sealing member in use defining a substantially sealed space, the receptacle including a fixed portion and a movable portion, the movable portion is connected to the fixed portion and movable relative to the fixed portion via the action of the gas pressure in the reservoir, an injection opening is formed in the movable portion, and a gas leakage path is supplied to the storage device a valve element is coupled to the fixed portion and cooperates with the injection opening and substantially seals it, one of which is greater than for the exterior of the receptacle The action of the internal gas pressure causes movement of the movable portion relative to the fixed portion and thus causes the valve member to move out of the closed contact with the injection opening, wherein the reservoir is a single piece of plastic casting comprising a diaphragm and the movable portion is via at least The annular fold line in the opposite direction is connected to the fixed portion, with respect to the outside of the reservoir, the effect of a large gas pressure on the inside thereof causes a rotational movement around the fold line and thus a movement of the movable portion, and the valve element And the exit openings together form a one-way valve that defines a gas leak path through which gas may flow into the reservoir rather than exiting it.

使用時,該開口將由一密封元件密封,並且該插入物將會部分充滿較佳地是液態的多成分系統的一種成分,並且將會被置於一包括多成分系統的另一成分的容器的內部。當該容器經由可能是與該插入物分離或可能是與其連接的一蓋或其他封閉物而密封時,該容器的內部,亦即位於其內部之成分上方的頭部空間被加壓。若容器內的成分係碳酸飲料,此加壓將會經由自其持續釋放的二氧化碳而自動發生。然而若容器內的成分並不含二氧化碳,並且是例如藥劑者,容器內的頭部空間內的此一加壓可以經由直接在容器被密封前增加幾滴例如液態氮至容器內而輕易地達成。氮氣的蒸發將會立即開始並且最初的蒸發將會導致頭部空間內的氣體被氮氣取代。在密封蓋的應用之後的後續的氮氣蒸發將會導致頭部空間的加壓。貯藏器內的氣體洩漏路徑將持續地許可加壓的氣體進入其內部,由其在貯藏器內的壓力將會達到一種實質同於加壓的容器的頭部空 間中的數值。當容器蓋被移走時,容器的頭部空間將會立即減壓。然而,隔膜中的洩漏路徑是夠小的,因此貯藏器的內部的立即減壓是不可能的,由其一位於整個貯藏器內的實質的壓力差將會被創造。如此將會對於貯藏器的可動部位起作用並將導致貯藏器的可動部位相對於,亦即是遠離固定部位的相對移動。遠離固定部位的可動部位的此一移動天生地產生遠離閥元件的射出開口的移動。此移動充足地將射出開口移離與閥元件的合作狀態,由其該射出開口現係打開的。在貯藏器內的較強的氣體壓力之後會將貯藏器內的成分經由射出開口排出至容器的主體內,於此其將與容器主體內的其他成分混合。該容器此時包括一個二成分混合物,其可能之後由一病人服用或使用。 In use, the opening will be sealed by a sealing element and the insert will be partially filled with a component of a preferably liquid multi-component system and will be placed in a container comprising another component of the multi-component system. internal. When the container is sealed via a lid or other closure that may be separate from or may be attached to the insert, the interior of the container, i.e., the head space above the components therein, is pressurized. If the ingredients in the container are carbonated beverages, this pressurization will occur automatically via the carbon dioxide that is continuously released therefrom. However, if the ingredients in the container do not contain carbon dioxide and are, for example, pharmacies, this pressurization in the head space within the container can be easily achieved by adding a few drops, such as liquid nitrogen, directly into the container before the container is sealed. . The evaporation of nitrogen will begin immediately and the initial evaporation will cause the gas in the head space to be replaced by nitrogen. Subsequent nitrogen evaporation after application of the sealing cap will result in pressurization of the head space. The gas leak path in the reservoir will continue to permit pressurized gas to enter the interior, and the pressure within the reservoir will reach a head that is substantially the same as the pressurized container. The value in between. When the container lid is removed, the head space of the container will be immediately decompressed. However, the leak path in the diaphragm is small enough that immediate decompression of the interior of the reservoir is not possible, and a substantial pressure differential across the entire reservoir will be created. This will act on the movable part of the receptacle and will result in a relative movement of the movable part of the receptacle relative to the fixed part. This movement of the movable portion away from the fixed portion naturally produces movement away from the injection opening of the valve member. This movement sufficiently moves the injection opening away from the cooperative state with the valve element, by which the injection opening is now open. After the strong gas pressure in the reservoir, the contents of the reservoir are discharged into the body of the container via the ejection opening where it will mix with other components within the container body. The container now includes a two component mixture which may then be taken or used by a patient.

貯藏器係一包括一隔膜的單件塑膠鑄件並且可動部位係經由至少二相反方向的環狀折疊線連接於固定部位,由其一較大於對於貯藏器外部之對於其內部的氣體壓力的作用導致在折疊線周圍的旋轉移動並且因此導致可動部位的移動。當此實施例之壓力差於整個貯藏器壁作用時,如此將會於各折疊線的各邊產生貯藏器的環狀部位的相對旋轉,其有效地構成一整合樞軸,並且此旋轉將會導致可動部位及因此之射出開口遠離固定部位而移動。 The reservoir is a single piece of plastic casting comprising a diaphragm and the movable portion is connected to the fixed portion via at least two oppositely folded circular fold lines, one of which is greater than the effect on the gas pressure on the exterior of the receptacle for the interior thereof. The rotational movement around the fold line and thus the movement of the movable part. When the pressure of this embodiment is less than the entire reservoir wall, this will result in relative rotation of the annular portion of the reservoir at each side of each fold line, which effectively constitutes an integrated pivot and this rotation will The movable portion and thus the exit opening are moved away from the fixed portion.

該閥元件及射出開口共同定義該氣體洩漏路徑,且這免除形成另一洩漏路徑的必要性。該閥元件及射出開口共同構成經由其氣體可能流入貯藏器中而不是由其流出之定義氣體洩漏路徑的一單向閥。 The valve element and the injection opening collectively define the gas leak path and this eliminates the need to form another leak path. The valve element and the injection opening together form a one-way valve that defines a gas leak path through which gas may flow into the reservoir rather than out of it.

該閥元件可能採取多種不同形式,但於一簡易之較佳實施例中,其構成整合地連接於周圍邊緣之栓塞或類似物。此栓塞通常將與射出開口合作,例如延伸進入其中並與其形成密閉,如此而能關閉射出開口並防止貯藏器內的成分的提早射出至容器中。就製造的理由而言,閥元件與貯藏器的固定部位的周圍邊緣整合在一起是便利的,並且如此將會使栓塞經由一鍊或某種連接器而連接於貯藏器變為必須。此鍊將先天即是相當長的,並且為了確保其維持在想要的位置,較佳地是該插入物包括一與由該鍊所嚙合的固定部位整合在一起的支撐元件並且固定它。 The valve element may take a variety of different forms, but in a simple preferred embodiment, it constitutes a plug or the like that is integrally connected to the peripheral edge. This plug will typically cooperate with the ejection opening, for example extending into and forming a seal therewith, thus closing the ejection opening and preventing premature ejection of components within the reservoir into the container. For reasons of manufacture, it is convenient to integrate the valve element with the peripheral edge of the fixed portion of the reservoir, and this will necessitate that the plug is attached to the reservoir via a chain or some type of connector. The chain will be quite long in nature and, in order to ensure that it is maintained in the desired position, it is preferred that the insert comprises a support member that is integrated with the fixation portion engaged by the chain and that secures it.

該閥元件及射出開口共同定義該氣體洩漏路徑,且此免除形成另一洩漏路徑的必要性。該閥元件及射出開口共同構成一經由其氣體可能流入貯藏器中而不是由其流出之定義氣體洩漏路徑的單向閥。 The valve element and the injection opening collectively define the gas leak path and this eliminates the need to form another leak path. The valve element and the injection opening together form a one-way valve that defines a gas leak path through which gas may flow into the reservoir rather than out of it.

該插入物可能與二成分容器一起被使用,並且在此種情形下,一成分將當然地被儲存於容器的主體中而另一成分位於插入物中。然而,本發明可應用於三或更多成分系統的容器,並且如此該貯藏器可能包括一或多將其分為二或多隔間的分割,其各自與一個別的流出開口溝通而各流出開口與一個別的閥元件合作。使用上,各隔間將當然地充滿一多成分系統的不同成分。於上所述之二較佳實施例的前一例中,較佳地是各流出開口與一個別的一組至少二隔開的環狀折疊線連用。 The insert may be used with a two-component container, and in this case one component will of course be stored in the body of the container and the other component in the insert. However, the invention is applicable to containers of three or more component systems, and as such the reservoir may include one or more divisions that divide it into two or more compartments, each communicating with a separate outflow opening and flowing out The opening cooperates with a different valve element. In use, each compartment will of course be filled with different components of a multi-component system. In the previous example of the preferred embodiment described above, it is preferred that each of the outflow openings be used in conjunction with a further set of at least two spaced apart annular fold lines.

該插入物能以未密封狀態供給於瓶子製造商或類似廠 商,亦即無由一密封元件密封的開口。該插入物在使用前將當然地必須被密封以防止其成分的洩漏或污染,並且該密封元件可能是一密封地連接於該隔膜周圍邊緣之塑膠材料或金屬或其合成物之薄片。本發明因此包括一具有或不具有一密封元件的插入物。 The insert can be supplied to the bottle manufacturer or similar factory in an unsealed state The quotient, that is, the opening that is not sealed by a sealing member. The insert will of course have to be sealed prior to use to prevent leakage or contamination of its constituents, and the sealing element may be a sheet of plastic material or metal or a composite thereof that is sealingly attached to the peripheral edge of the membrane. The invention thus includes an insert with or without a sealing element.

該插入物可以被應用於一型態為一個別組件的容器,且蓋子或其他封閉物之後應用於該容器。然而,若該插入物與封閉物構成一合成單位將會是便利的,它們因此之後被同時應用於該容器。這種封閉物將包括一封閉板,其在使用上係延伸橫越容器中的配送開口,並且因此就塑膠材料或類似物之密封板而言被省略,以及就封閉板而言係構成插入物的密封元件,是有可能的。 The insert can be applied to a container that is a separate component and a lid or other closure is applied to the container. However, it would be convenient if the insert and the closure constituted a synthetic unit, which were then simultaneously applied to the container. Such a closure will comprise a closure panel that extends across the dispensing opening in the container in use and is therefore omitted in the case of a sealing sheet of plastic material or the like, and as an insert in the case of a closure panel The sealing element is possible.

例示於第1至第5圖中之插入物構成一聚丙烯或類似物之單件鑄件。然而,其亦可由金屬箔或由一以沖製或壓製成型之包括金屬與塑膠材料的合成物所製成。當該插入物自模具中射出時,其具有顯示於第1圖中之配置。其包括一頂端開放、通常為杯狀的元件2,於其底座中形成者係一依靠袋4。依靠袋4的向下及向內傾斜的環狀壁係由複數隔開的及細的環狀線,亦即由減少厚度的線所形成,其功能將於文後敘述。形成於袋4的底座中係一流出開口6,其係由一彈性邊緣唇8所定義,此於第5圖中可見。一周圍突緣10係與插入物的上部周圍邊緣整合地鑄造,與該突緣整合地被鑄造者係一通常側向地延伸的延長連接器鍊12的一端。與鍊12空著的一端整合的係一栓塞14,其係以剛鑄 造的狀態垂直地向上延伸。於袋4外放射狀地與杯狀元件2的底座整合地被鑄造者係一直立支撐物16。支撐物16包括一直立網,於其上部表面的二末端有各自的直立突起物18,其之間的空間大致等於鍊12的寬度。支撐物16因此於由二突起物18所定義之其上部產生一通常為長方形的凹槽。然而,此支撐物可以是非必須的並且因此可以被省略。 The inserts exemplified in Figs. 1 to 5 constitute a one-piece casting of polypropylene or the like. However, it can also be made of a metal foil or a composite comprising a metal and a plastic material which is formed by stamping or press molding. When the insert is ejected from the mold, it has the configuration shown in Figure 1. It comprises an open top, usually cup-shaped element 2, which is formed in its base by a pocket 4. The downwardly and inwardly inclined annular wall of the bag 4 is formed by a plurality of spaced and thin annular lines, i.e., formed by lines of reduced thickness, the function of which will be described later. Formed in the base of the bag 4 is a first-class opening 6 defined by a resilient edge lip 8, as seen in Figure 5. A peripheral flange 10 is integrally cast with the upper peripheral edge of the insert, integrally formed with the flange by an end of the elongated connector chain 12 that extends generally laterally. a plug 14 integrated with the empty end of the chain 12, which is cast The state of creation extends vertically upwards. The caster is an upright support 16 that is radially integrated with the base of the cup element 2 outside the bag 4. The support 16 includes an upright web having respective upstanding projections 18 at the two ends of its upper surface, the space between which is substantially equal to the width of the chain 12. The support 16 thus produces a generally rectangular recess in the upper portion defined by the two projections 18. However, this support may be unnecessary and thus may be omitted.

此插入物現經由應用一向上力至袋4的較低末端而被引至運作的配置。如此導致袋4的環狀壁起縐折,亦即在細的環狀線附近折疊,相鄰的折疊係相反的方向。袋4被向上移動直至通常其位於杯狀部位2的底座的剩餘物的相同高度。在此之前或之後,鍊12以反時鐘方向被旋轉180度,如第1圖中可見者,直至其達到顯示於第2圖中的位置。於本例中係截頭圓錐體之栓塞之空著的一端,被插入至由向上延伸的唇8所定義的開口6之中。唇8的內部直徑與栓塞14的外部直徑互相係如此吻合,因此栓塞14對於唇8向外擴張,由其唇8被驅使而與栓塞14的表面接觸並且因此與其形成一實質氣體密封。當處於此位置時,鍊12被支撐於支撐物16的上部表面上並由突起物18限制其向側面移動。 This insert is now brought to the operational configuration via application of an upward force to the lower end of the bag 4. This causes the annular wall of the bag 4 to collapse, i.e., fold near the thin loop line, with adjacent folds in opposite directions. The bag 4 is moved upwards until it is normally at the same height of the remainder of the base of the cup portion 2. Before or after this, the chain 12 is rotated 180 degrees in the counterclockwise direction, as seen in Figure 1, until it reaches the position shown in Figure 2. The empty end of the plug of the frustoconical body in this example is inserted into the opening 6 defined by the upwardly extending lip 8. The inner diameter of the lip 8 coincides with the outer diameter of the plug 14, so that the plug 14 expands outwardly for the lip 8, being driven by its lip 8 to contact the surface of the plug 14 and thus form a substantial gas seal therewith. When in this position, the chain 12 is supported on the upper surface of the support 16 and is constrained to move laterally by the projections 18.

該插入物之後部分被充滿液體或粉末狀的想要的物質,並且於本例中其將被假設為此物質係一種以混合的形式服用但以混合的形式長久而言係不穩定的二成分藥物的其中一成分。該插入物之後經由連接至其上部周圍邊緣10的上部表面一密封薄膜20而被密封,其較佳地是由金屬化 塑膠材料所構成因為這種合成材料對於液體及蒸汽均係不可滲透的。該插入物現已可使用。 The insert is partially filled with the desired substance in liquid or powder form, and in this case it will be assumed that the substance is a two-component that is taken in a mixed form but is unstable in a mixed form for a long time. One of the ingredients of the drug. The insert is then sealed via a sealing film 20 attached to the upper surface of its upper peripheral edge 10, which is preferably metallized The plastic material is constructed because this synthetic material is impermeable to both liquid and vapor. This insert is now ready for use.

在插入物放置於容器內之前,有一風險是一衝擊或其他力量可能偶然地被應用於栓塞的暴露端,並且如此可能導致插入物的成分的洩漏或甚至完全滅失。為了將此風險的發生降到最低,一小修改可以被啟用,如於第3圖中所顯示者。如此係由提供插入物的外部一延伸大約至栓塞14的暴露端且延伸向下至低於栓塞末端的一點,整合的、依賴的環狀突緣40所組成。此可由一些個別的突出物所取代之突緣將保護栓塞的末端不受衝擊。 Before the insert is placed in the container, there is a risk that an impact or other force may accidentally be applied to the exposed end of the plug, and as such may result in leakage or even complete loss of the components of the insert. In order to minimize this risk, a small modification can be enabled, as shown in Figure 3. This is accomplished by providing an integrated, dependent annular flange 40 extending from the exterior of the insert to approximately the exposed end of the plug 14 and extending down to a point below the end of the plug. This flange, which can be replaced by a number of individual protrusions, will protect the end of the plug from impact.

該插入物能以多種不同的方式被使用,但其最簡單的形式是被放置於二成分容器的頸部內,其已包含上所提及之二成分藥物的另一成分,其周圍突緣10係休止於容器的邊緣。在將該插入物置於容器的邊緣上之前,數滴液態氮被插入至容器內並且一外部密封蓋之後迅速地在所有氮氣蒸發前蓋上。液態氮最初的蒸發將使容器的頭部空間充滿氮氣並且將所有空氣及任何包含於其中的細菌移出。發生於蓋上蓋子後之氮氣隨後的蒸發將增加容器的頭部空間內的壓力至一極大氣壓程度。當此壓力增加,唇8將會向外凹陷而打開一進入插入物內部的小的氣體洩漏路徑。於插入物內部的壓力將因此隨時間經過而達到一大致等同於容器的頭部空間內的數值。 The insert can be used in a number of different ways, but in its simplest form is placed in the neck of a two-component container that already contains another component of the two-component drug mentioned above, with a peripheral flange The 10 series rests on the edge of the container. A few drops of liquid nitrogen were inserted into the container before the insert was placed on the edge of the container and quickly sealed before all of the nitrogen was evaporated after an external sealing cap. The initial evaporation of liquid nitrogen will fill the head space of the vessel with nitrogen and remove all air and any bacteria contained therein. Subsequent evaporation of nitrogen after the lid is placed will increase the pressure in the head space of the container to a maximum pressure. As this pressure increases, the lip 8 will sag outwardly to open a small gas leak path into the interior of the insert. The pressure inside the insert will thus pass over time to a value substantially equivalent to that in the head space of the container.

當想要服用該二成分藥物時,該容器蓋被移除。如此將導致容器頭部空間的立即減壓。然而,由唇8與栓塞14 的嚙合所構成的閥,經由唇8的適應,係一單向閥。該插入物的內部因此並不立即減壓並且於袋4的整個壁上有一實質的壓力差。如此導致袋的立即向下移動,伴隨於其環狀壁中的多折疊的同時打開的發生,此一打開於相鄰折疊間係以相反的方向為之。當該袋的較低部位向下移動,流出開口6的邊緣8將會移離與固定的栓塞14的接觸。流出開口6現係無阻塞的且在插入物的內部之藥物之上之較強的極大氣壓現作用而迅速地經由開口6將藥物排出至容器內,於該處其將經由高速噴射經過開口6所產生的混合動作的幫助,與已位於容器內的藥物混合。該袋的尺寸的設計及容器可以被充滿至一種開口6位於容器中的液體的高度之下的程度,儘管上述並非必須的。該插入物的配置現將如顯示於第4圖中者並且可以被丟棄。該二成分藥物現可以由病人服用。 When the two-component drug is to be taken, the container lid is removed. This will result in an immediate decompression of the container head space. However, by the lip 8 and the plug 14 The valve formed by the engagement is adapted to be a one-way valve via the adaptation of the lip 8. The interior of the insert is therefore not immediately decompressed and there is a substantial pressure differential across the entire wall of the bag 4. This results in an immediate downward movement of the bag, accompanied by the simultaneous opening of multiple folds in its annular wall, which opens in the opposite direction of the adjacent fold. As the lower portion of the bag moves downward, the edge 8 of the outflow opening 6 will move out of contact with the fixed plug 14. The outflow opening 6 is now non-blocking and the strong maximum pressure above the drug inside the insert acts to rapidly expel the drug through the opening 6 into the container where it will be ejected through the opening 6 via high velocity. The resulting mixing action is aided by mixing with the medication already in the container. The design of the bag and the container can be filled to the extent that the opening 6 is below the level of liquid in the container, although this is not required. The configuration of the insert will now be as shown in Figure 4 and can be discarded. The two component drug can now be taken by the patient.

如上所述,根據本發明的插入物及封閉物或蓋子分別被應用於容器。然而將插入物與蓋子整合將會是更便利的,並且這樣的結構顯示於第6圖中。這樣一種整合的結構可能包括一如第1至第5圖中所例示之例如經由一推入結合或經由黏著劑或類似之物而固定於蓋子內之插入物。然而,此蓋子將必須具有一於第6圖中被指示為22之覆蓋板,其將延伸於容器內的開口之上並且可能亦在一依靠周圍裙之上,若該容器係具有一形成於頸部的配送開口之傳統形式,其具有一螺紋或類似物(未顯示)。封閉板22開啟省略密封薄膜20的可能性,其功能之後由覆蓋板22所 完成,覆蓋板22係經由任何適當的方式密封於插入物的上部突緣10。 As mentioned above, the inserts and closures or lids according to the invention are applied to the containers, respectively. However, it would be more convenient to integrate the insert with the lid, and such a structure is shown in Figure 6. Such an integrated structure may include an insert that is affixed to the cover, such as by a push-in bond or via an adhesive or the like, as exemplified in Figures 1 through 5. However, the cover will have to have a cover plate, indicated as 22 in Figure 6, which will extend over the opening in the container and possibly also over a peripheral skirt if the container has a The conventional form of the dispensing opening of the neck has a thread or the like (not shown). The closing plate 22 opens the possibility of omitting the sealing film 20, the function of which is followed by the cover plate 22 Upon completion, the cover panel 22 is sealed to the upper flange 10 of the insert by any suitable means.

將能被理解的是上所述之插入物及蓋子係供與一種二成分容器使用,亦即一種包括一成分於容器主體內而將與其混合之第二種成分位於插入物中之容器。然而,根據本發明之插入物及蓋子亦能被使用於包含三或更多種不同成分而在使用或服用前不久混合的容器。如此於一並未例示之修正的實施例中,該插入物係供與一包括三種不同成分的容器一起使用。杯狀元件2的底座係由二組環狀的,較佳地是同心的相反方向折疊線所形成,一個別射出開口位於各組折疊線內。由插入物所定義之貯藏器的內部經由一分割被分為二隔間,該分割係與該插入物的側壁與底座整合並且延伸於二組折疊線之間,由其各隔間與一各自的流出開口溝通。並且,與杯狀元件整合形成的是二與各自的流出開口合作的栓塞及鍊,其大致同於第1至第6圖中所示者。將能被瞭解的是,在使用上該二成分將被充滿不同成分並且插入物的運作本質上同於上所述者,唯一的差別係當容器被打開時,該二流出開口皆將向下移動並因此移離與相關栓塞的接觸,由其該二流出開口將大致同時打開,並且該二隔間的成分將大致同時被排出至容器的主體內,並且將與已經位於容器主體內的成分混合。 It will be understood that the inserts and lids described above are for use with a two-component container, i.e., a container comprising a second component which is contained within the container body and which is mixed therewith. However, the inserts and lids according to the present invention can also be used in containers containing three or more different ingredients that are mixed shortly before use or administration. Thus in an embodiment not illustrated, the insert is for use with a container comprising three different components. The base of the cup member 2 is formed by two sets of annular, preferably concentric, oppositely directed fold lines, one of which is located within each set of fold lines. The interior of the receptacle defined by the insert is divided into two compartments via a split, the splitting system being integrated with the side wall of the insert and the base and extending between the two sets of fold lines, each compartment and a respective compartment The outflow opening communicates. Also, integrated with the cup-like elements are two plugs and chains that cooperate with the respective outflow openings, which are substantially the same as those shown in Figures 1 to 6. It will be appreciated that in use the two components will be filled with different ingredients and the operation of the insert will be essentially the same as described above, the only difference being that when the container is opened, the two outflow openings will all be downwards. Moving and thus moving away from contact with the associated plug, by which the two outflow openings will open substantially simultaneously, and the components of the two compartments will be expelled substantially simultaneously into the body of the container and will be with the ingredients already within the body of the container mixing.

2‧‧‧固定部位 2‧‧‧Fixed parts

4‧‧‧袋 4‧‧‧ bags

6‧‧‧開口 6‧‧‧ openings

8‧‧‧唇 8‧‧‧ lips

10‧‧‧周圍突緣 10‧‧‧ peripheral flange

12‧‧‧鍊 12‧‧‧ chain

14‧‧‧栓塞 14‧‧ ‧ embolization

16‧‧‧支撐物 16‧‧‧Support

18‧‧‧突起物 18‧‧‧Protrusions

20‧‧‧密封薄膜 20‧‧‧Seal film

22‧‧‧覆蓋板 22‧‧‧ Covering board

30‧‧‧底部部位 30‧‧‧ bottom part

32‧‧‧側壁 32‧‧‧ side wall

40‧‧‧環狀突緣 40‧‧‧Aperture flange

34、36‧‧‧突點 34, 36‧‧‧

由下列經由僅參考附圖而供給的範例之某些特定實施例之敘述,本發明之其他特徵及細節將會變得明顯,其中:第1圖係一根據本發明之插入物於「剛鑄造狀態」下之一實施例之軸垂直斷面圖;第2圖係第1圖的插入物之操作配置之軸垂直斷面圖;第3圖係額外地顯示一可選擇的修改的第2圖中的線3-3上的軸垂直斷面圖;第4圖係一顯示在其成分已被排出進入容器中之插入物之類似於第1及第2圖之圖示;第5圖係一顯示位於流出開口中之較大比例之剪貼圖;及第6圖係顯示一根據本發明整合一插入物之容器蓋之類似於第3圖之圖示。 Further features and details of the present invention will become apparent from the following description of the <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; "Axis vertical sectional view of one embodiment of the state"; Fig. 2 is an axial vertical sectional view of the operational configuration of the insert of Fig. 1; Fig. 3 additionally shows an alternative modified second drawing A vertical cross-sectional view of the shaft on line 3-3; Figure 4 is a diagram similar to the first and second figures of the insert whose components have been discharged into the container; Figure 5 is a diagram A larger scale clip art is shown in the outflow opening; and Fig. 6 shows an illustration similar to Fig. 3 of a container lid incorporating an insert in accordance with the present invention.

22‧‧‧覆蓋板 22‧‧‧ Covering board

Claims (10)

一種多成分容器的插入物,包括一貯藏器(2、4),該貯藏器(2、4)具有一開口,該開口係由一週圍邊緣所定義,用以與一密封元件(20)嚙合,該貯藏器(2、4)在使用上與一密封元件(20)共同定義一實質密封空間,該貯藏器(2、4)包括一固定部位(2)及一可動部位,該可動部位與該固定部位(2)相連並且經由貯藏器(2、4)內的氣體壓力的動作而相對於該固定部位(2)係可動的,一射出開口(6),其於該可動部位中形成,一氣體洩漏路徑,供給於該貯藏器(2、4)中,一閥元件(14),其與該固定部位(2)連接並且與該射出開口(6)合作並實質將其密封,藉此,應用較對於該貯藏器(2、4)外部大之對於其內部之一氣體壓力可導致該可動部位相對於該固定部位(2)的移動,並且因此導致該閥元件(14)移離與該射出開口(6)的密封接觸,其特徵在於,該貯藏器(2、4)係包括一隔膜的一單件塑膠鑄件並且該可動部位係經由至少二相反方向的環狀折疊線連接於該固定部位(2),由此相對於貯藏器(2、4)的外部,對於貯藏器(2、4)的內部的一較大氣體壓力的作用導致在該折疊線周圍的旋轉移動並且因此導致該可動部位的移動,以及該閥元件(14)及該射出開口(6)共同構成經由其氣體可能流入該貯藏器(2、4)中而不是由其流出之定義該氣體洩漏路徑的一單向閥。 An insert for a multi-component container comprising a receptacle (2, 4) having an opening defined by a peripheral edge for engaging a sealing member (20) The container (2, 4) is used together with a sealing member (20) to define a substantially sealed space, the container (2, 4) comprising a fixed portion (2) and a movable portion, the movable portion and the movable portion The fixing portion (2) is connected and movable relative to the fixing portion (2) via the action of the gas pressure in the reservoir (2, 4), and an opening (6) is formed in the movable portion. a gas leak path, supplied to the reservoir (2, 4), a valve element (14) connected to the fixed portion (2) and cooperating with the injection opening (6) and substantially sealing it Applying a gas pressure to the outside of the reservoir (2, 4) for one of its internal gases may cause movement of the movable portion relative to the fixed portion (2) and thus cause the valve element (14) to move away from Sealing contact of the injection opening (6), characterized in that the receptacle (2, 4) is a single piece of plastic casting comprising a diaphragm And the movable portion is connected to the fixed portion (2) via at least two annular folding lines in opposite directions, whereby the inside of the receptacle (2, 4) is opposite to the outside of the receptacle (2, 4) The action of the larger gas pressure causes a rotational movement around the fold line and thus a movement of the movable portion, and the valve element (14) and the injection opening (6) together constitute a possible flow of gas through the reservoir (2) , a 4) check valve that defines the gas leak path instead of flowing out of it. 如申請專利範圍第1項之插入物,其中該閥元件(14) 構成一整合地與該周圍邊緣連接的栓塞。 The insert of claim 1, wherein the valve element (14) A plug that is integrally connected to the peripheral edge is formed. 申請專利範圍第2項之插入物,其包括一與固定部位整合之支撐元件(16)及栓塞(14),經由一嚙合的鍊(12)與該周圍邊緣連接,並且由該支撐元件(16)穩固。 The insert of claim 2, comprising a support member (16) and a plug (14) integrated with the fixed portion, connected to the peripheral edge via an engaging chain (12), and supported by the support member (16) )stable. 如先前申請專利範圍中任一項之插入物,其中該貯藏器包括將其分為二或多隔間之一或多分割,各隔間與一各自的流出開口溝通而各流出開口(6)與各自的閥元件(14)合作。 An insert according to any one of the preceding claims, wherein the receptacle comprises dividing one or more compartments into two or more compartments, each compartment communicating with a respective outflow opening and each outflow opening (6) Cooperate with the respective valve element (14). 如申請專利範圍第2及第8項之插入物,其中各流出開口(6)係與各自的一組至少二隔開的環狀折疊線聯合。 An insert according to claims 2 and 8 wherein each of the outflow openings (6) is associated with a respective set of at least two spaced apart annular fold lines. 如申請專利範圍第1項之插入物,其包括一密封元件(20),該密封元件(20)與該貯藏器連接。 The insert of claim 1 includes a sealing element (20) that is coupled to the reservoir. 如申請專利範圍第6項之插入物,其中該密封元件(20)係一塑膠材料或金屬的薄片或其組合物,其與該周圍邊緣密封地連接。 The insert of claim 6, wherein the sealing element (20) is a sheet of plastic material or metal or a combination thereof that is sealingly joined to the peripheral edge. 一種多成分容器的封閉物,包括與其連接的如前述申請專利範圍中任一項之插入物。 A closure for a multi-component container comprising an insert of any of the preceding claims in connection therewith. 一種多成分容器的封閉物,包括如申請專利範圍第6項之插入物及一封閉板(22),在使用上延伸橫越該容器的一開口,該封閉板(22)構成該密封元件。 A closure for a multi-component container comprising an insert as claimed in claim 6 and a closure panel (22) extending across the opening of the container in use, the closure panel (22) forming the sealing member. 一如申請專利範圍第9項之封閉物,包括如申請專利範圍第3項之一插入物,其中該封閉板(22)及該貯藏器的固定部位(2)構成一單件塑膠鑄件。 A closure according to claim 9 of the patent application, comprising an insert according to item 3 of the patent application, wherein the closure plate (22) and the fixing portion (2) of the container constitute a single piece of plastic casting.
TW95139619A 2006-01-18 2006-10-26 Inserts for multiple component containers TWI392629B (en)

Applications Claiming Priority (1)

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GB0601018A GB0601018D0 (en) 2006-01-18 2006-01-18 Inserts for multiple component containers

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TW200728162A TW200728162A (en) 2007-08-01
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EP (1) EP1973799B1 (en)
JP (1) JP5101524B2 (en)
KR (1) KR101319796B1 (en)
CN (1) CN101360658B (en)
AU (1) AU2006335995B2 (en)
BR (1) BRPI0621191A2 (en)
CA (1) CA2637746A1 (en)
GB (1) GB0601018D0 (en)
HK (1) HK1122254A1 (en)
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GB0601018D0 (en) 2006-03-01
UA92928C2 (en) 2010-12-27
CN101360658B (en) 2010-05-19
RU2008131903A (en) 2010-02-27
KR101319796B1 (en) 2013-10-17
TW200728162A (en) 2007-08-01
HK1122254A1 (en) 2009-05-15
BRPI0621191A2 (en) 2011-12-06
US20070163898A1 (en) 2007-07-19
JP2009523666A (en) 2009-06-25
RU2410306C2 (en) 2011-01-27
CA2637746A1 (en) 2007-07-26
AU2006335995B2 (en) 2011-11-03
EP1973799B1 (en) 2013-07-03
AU2006335995A1 (en) 2007-07-26
WO2007083074A1 (en) 2007-07-26
CN101360658A (en) 2009-02-04
KR20080094677A (en) 2008-10-23
JP5101524B2 (en) 2012-12-19
EP1973799A1 (en) 2008-10-01

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