TWI350373B - Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators - Google Patents

Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators

Info

Publication number
TWI350373B
TWI350373B TW094101411A TW94101411A TWI350373B TW I350373 B TWI350373 B TW I350373B TW 094101411 A TW094101411 A TW 094101411A TW 94101411 A TW94101411 A TW 94101411A TW I350373 B TWI350373 B TW I350373B
Authority
TW
Taiwan
Prior art keywords
transferase activity
methods
screening
formethyl
modulators
Prior art date
Application number
TW094101411A
Other languages
English (en)
Other versions
TW200533920A (en
Inventor
Yusuke Nakamura
Yoichi Furukawa
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of TW200533920A publication Critical patent/TW200533920A/zh
Application granted granted Critical
Publication of TWI350373B publication Critical patent/TWI350373B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
    • G01N2333/91011—Methyltransferases (general) (2.1.1.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
TW094101411A 2004-01-23 2005-01-18 Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators TWI350373B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53865804P 2004-01-23 2004-01-23

Publications (2)

Publication Number Publication Date
TW200533920A TW200533920A (en) 2005-10-16
TWI350373B true TWI350373B (en) 2011-10-11

Family

ID=34807204

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094101411A TWI350373B (en) 2004-01-23 2005-01-18 Methods of detecting methyl transferase activity and methods of screening formethyl transferase activity modulators

Country Status (11)

Country Link
US (1) US8221993B2 (zh)
EP (1) EP1718761B1 (zh)
JP (1) JP4614954B2 (zh)
KR (1) KR20060129025A (zh)
CN (1) CN1954082B (zh)
AT (1) ATE421596T1 (zh)
CA (1) CA2554053A1 (zh)
DE (1) DE602005012483D1 (zh)
ES (1) ES2321527T3 (zh)
TW (1) TWI350373B (zh)
WO (1) WO2005071102A2 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60218710T2 (de) * 2001-09-25 2007-12-06 Oncotherapy Science, Inc., Kawasaki Gen und protein mit bezug zu hepatozellulärem karzinom
CA2399569A1 (en) * 2001-09-25 2003-03-25 Yusuke Nakamura Diagnostic markers and drug targets for treatment of cancer
WO2006092958A1 (en) 2005-02-28 2006-09-08 Oncotherapy Science, Inc. Breast cancer related gene znfn3a1
TW200741009A (en) 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
US8354223B2 (en) 2007-06-14 2013-01-15 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of VEGFR1 by SMYD3
CN101928749A (zh) * 2010-06-11 2010-12-29 济南大学 一种S-腺苷甲硫氨酸(AdoMet)依赖的甲基转移酶的检测方法
US20130210664A1 (en) * 2010-08-05 2013-08-15 Cellzome Ag Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins
KR101217866B1 (ko) * 2010-08-18 2013-01-03 한국원자력의학원 혈관신생 억제용 약학 조성물 및 혈관신생 억제용 활성물질을 스크리닝하는 방법
US9746470B2 (en) * 2011-05-09 2017-08-29 Whitehead Institute For Biomedical Research Chaperone interaction assays and uses thereof
JP6051373B2 (ja) 2011-12-02 2016-12-27 オンコセラピー・サイエンス株式会社 癌の治療および診断の標的遺伝子としてのｓｍｙｄ２
CN102590509A (zh) * 2012-03-20 2012-07-18 湖南大学 基于无修饰抗体介导纳米金组装检测组蛋白修饰酶活性及筛选其抑制剂的生物传感方法
CN104990973B (zh) * 2015-07-06 2017-12-15 济南大学 一种固载甲基转移酶电极传感器的制备及应用
MX2018003903A (es) 2015-09-29 2018-09-21 Oncotherapy Science Inc Compuesto biciclico y uso del mismo para inhibicion de suv39h2.

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US6133437A (en) * 1997-02-13 2000-10-17 Apoptogen, Inc. Modulation of IAPs for the treatment of proliferative diseases
EP0856579A1 (en) 1997-01-31 1998-08-05 BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH An antisense oligonucleotide preparation method
WO1998039904A1 (en) 1997-03-07 1998-09-11 Telefonaktiebolaget Lm Ericsson (Publ) 'return to prior agent' feature in multi-destination call delivery services
WO2000017355A2 (en) 1998-09-18 2000-03-30 Incyte Pharmaceuticals, Inc. Human cytoskeleton associated proteins
CA2359701A1 (en) 1999-01-29 2000-08-03 Incyte Pharmaceuticals, Inc. Nucleic-acid binding proteins
MXPA03006617A (es) 2001-01-24 2004-12-02 Protein Design Labs Inc Metodos de diagnostico de cancer de pecho, composiciones y metodos de rastreo de moduladores de cancer de pecho.
GB0111218D0 (en) * 2001-05-08 2001-06-27 Cancer Res Ventures Ltd Assays methods and means
EP1480597A4 (en) 2001-05-11 2005-02-02 Burnham Inst SCREENING, DIAGNOSTIC AND THERAPY PROCEDURES IN CONNECTION WITH RIZ
US6955905B2 (en) * 2001-07-18 2005-10-18 The Burnham Institute PR/SET-domain containing nucleic acids, polypeptides, antibodies and methods of use
CA2936534C (en) 2001-07-23 2021-01-26 The Board Of Trustees Of Leland Stanford Junior University Methods and compositions for rnai mediated inhibition of gene expression in mammals
DE60218710T2 (de) * 2001-09-25 2007-12-06 Oncotherapy Science, Inc., Kawasaki Gen und protein mit bezug zu hepatozellulärem karzinom
JP3742415B2 (ja) 2003-02-10 2006-02-01 三洋化成工業株式会社 Ｒｂ１遺伝子産物に対する自己抗体を検出するための免疫測定用試薬
EP1599586B9 (en) 2003-02-28 2012-03-14 Oncotherapy Science, Inc. Rna-interference for znfn3a1-gene as a method for inhibiting cancer cell growth
WO2006092958A1 (en) * 2005-02-28 2006-09-08 Oncotherapy Science, Inc. Breast cancer related gene znfn3a1
TW200741009A (en) * 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
US8354223B2 (en) * 2007-06-14 2013-01-15 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of VEGFR1 by SMYD3

Also Published As

Publication number Publication date
CA2554053A1 (en) 2005-08-04
TW200533920A (en) 2005-10-16
WO2005071102A2 (en) 2005-08-04
JP2007519391A (ja) 2007-07-19
CN1954082B (zh) 2011-08-17
CN1954082A (zh) 2007-04-25
US20090035303A1 (en) 2009-02-05
JP4614954B2 (ja) 2011-01-19
WO2005071102A3 (en) 2005-11-17
DE602005012483D1 (de) 2009-03-12
EP1718761A2 (en) 2006-11-08
ES2321527T3 (es) 2009-06-08
ATE421596T1 (de) 2009-02-15
EP1718761B1 (en) 2009-01-21
KR20060129025A (ko) 2006-12-14
US8221993B2 (en) 2012-07-17

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