ATE421596T1 - Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität - Google Patents
Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivitätInfo
- Publication number
- ATE421596T1 ATE421596T1 AT05704225T AT05704225T ATE421596T1 AT E421596 T1 ATE421596 T1 AT E421596T1 AT 05704225 T AT05704225 T AT 05704225T AT 05704225 T AT05704225 T AT 05704225T AT E421596 T1 ATE421596 T1 AT E421596T1
- Authority
- AT
- Austria
- Prior art keywords
- transferase activity
- methyl transferase
- modulators
- screening
- detecting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53865804P | 2004-01-23 | 2004-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421596T1 true ATE421596T1 (de) | 2009-02-15 |
Family
ID=34807204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05704225T ATE421596T1 (de) | 2004-01-23 | 2005-01-21 | Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8221993B2 (de) |
| EP (1) | EP1718761B1 (de) |
| JP (1) | JP4614954B2 (de) |
| KR (1) | KR20060129025A (de) |
| CN (1) | CN1954082B (de) |
| AT (1) | ATE421596T1 (de) |
| CA (1) | CA2554053A1 (de) |
| DE (1) | DE602005012483D1 (de) |
| ES (1) | ES2321527T3 (de) |
| TW (1) | TWI350373B (de) |
| WO (1) | WO2005071102A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2399569A1 (en) * | 2001-09-25 | 2003-03-25 | Yusuke Nakamura | Diagnostic markers and drug targets for treatment of cancer |
| EP1430152B1 (de) * | 2001-09-25 | 2007-03-07 | Japan as represented by The President of the University of Tokyo | Gen und protein mit bezug zu hepatozellulärem karzinom |
| US7939254B2 (en) | 2005-02-28 | 2011-05-10 | Oncotherapy Science, Inc. | Breast cancer related gene ZNFN3A1 |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| WO2008152816A1 (en) * | 2007-06-14 | 2008-12-18 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
| CN101928749A (zh) * | 2010-06-11 | 2010-12-29 | 济南大学 | 一种S-腺苷甲硫氨酸(AdoMet)依赖的甲基转移酶的检测方法 |
| US20130210664A1 (en) * | 2010-08-05 | 2013-08-15 | Cellzome Ag | Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins |
| KR101217866B1 (ko) | 2010-08-18 | 2013-01-03 | 한국원자력의학원 | 혈관신생 억제용 약학 조성물 및 혈관신생 억제용 활성물질을 스크리닝하는 방법 |
| EP2707714B1 (de) * | 2011-05-09 | 2019-10-09 | Whitehead Institute For Biomedical Research | Chaperon-interaktionsassay und anwendungen davon |
| EP2785870B1 (de) | 2011-12-02 | 2017-05-03 | OncoTherapy Science, Inc. | Smyd2 als zielgen für krebstherapie und -diagnose |
| CN102590509A (zh) * | 2012-03-20 | 2012-07-18 | 湖南大学 | 基于无修饰抗体介导纳米金组装检测组蛋白修饰酶活性及筛选其抑制剂的生物传感方法 |
| CN104990973B (zh) * | 2015-07-06 | 2017-12-15 | 济南大学 | 一种固载甲基转移酶电极传感器的制备及应用 |
| EP3355699B1 (de) | 2015-09-29 | 2021-03-31 | OncoTherapy Science, Inc. | Bicyclische verbindung und verwendung davon zur hemmung von suv39h2 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133437A (en) * | 1997-02-13 | 2000-10-17 | Apoptogen, Inc. | Modulation of IAPs for the treatment of proliferative diseases |
| EP0856579A1 (de) | 1997-01-31 | 1998-08-05 | BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH | Ein Verfahren zur Zubereitung von Antisense Oligonukleotiden |
| WO1998039904A1 (en) | 1997-03-07 | 1998-09-11 | Telefonaktiebolaget Lm Ericsson (Publ) | 'return to prior agent' feature in multi-destination call delivery services |
| WO2000017355A2 (en) | 1998-09-18 | 2000-03-30 | Incyte Pharmaceuticals, Inc. | Human cytoskeleton associated proteins |
| EP1144625A2 (de) | 1999-01-29 | 2001-10-17 | Incyte Pharmaceuticals, Inc. | Nukleinsäure bindende proteine |
| EP1425302A2 (de) | 2001-01-24 | 2004-06-09 | Protein Design Labs | Methoden zur diagnose von brustkrebs sowie methoden zur identifizierung von substanzen, die brustkrebs beeinflussen |
| GB0111218D0 (en) * | 2001-05-08 | 2001-06-27 | Cancer Res Ventures Ltd | Assays methods and means |
| EP1480597A4 (de) | 2001-05-11 | 2005-02-02 | Burnham Inst | Screening-, diagnose- und therapieverfahren im zusammenhang mit riz |
| US6955905B2 (en) * | 2001-07-18 | 2005-10-18 | The Burnham Institute | PR/SET-domain containing nucleic acids, polypeptides, antibodies and methods of use |
| ATE556720T1 (de) | 2001-07-23 | 2012-05-15 | Univ Leland Stanford Junior | Verfahren und zusammensetzungen zur rnai vermittelten inhibierung der genexpression in säugetieren |
| EP1430152B1 (de) * | 2001-09-25 | 2007-03-07 | Japan as represented by The President of the University of Tokyo | Gen und protein mit bezug zu hepatozellulärem karzinom |
| JP3742415B2 (ja) | 2003-02-10 | 2006-02-01 | 三洋化成工業株式会社 | Ｒｂ１遺伝子産物に対する自己抗体を検出するための免疫測定用試薬 |
| JP4467559B2 (ja) | 2003-02-28 | 2010-05-26 | オンコセラピー・サイエンス株式会社 | 細胞増殖を阻害する組成物および方法 |
| US7939254B2 (en) * | 2005-02-28 | 2011-05-10 | Oncotherapy Science, Inc. | Breast cancer related gene ZNFN3A1 |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| WO2008152816A1 (en) | 2007-06-14 | 2008-12-18 | Oncotherapy Science, Inc. | Methods of identifying agents that modulate methylation of vegfr1 by smyd3 |
-
2005
- 2005-01-18 TW TW094101411A patent/TWI350373B/zh not_active IP Right Cessation
- 2005-01-21 DE DE602005012483T patent/DE602005012483D1/de active Active
- 2005-01-21 CA CA002554053A patent/CA2554053A1/en not_active Abandoned
- 2005-01-21 KR KR1020067016868A patent/KR20060129025A/ko active IP Right Grant
- 2005-01-21 ES ES05704225T patent/ES2321527T3/es active Active
- 2005-01-21 CN CN2005800096304A patent/CN1954082B/zh not_active Expired - Fee Related
- 2005-01-21 JP JP2006520534A patent/JP4614954B2/ja not_active Expired - Fee Related
- 2005-01-21 AT AT05704225T patent/ATE421596T1/de not_active IP Right Cessation
- 2005-01-21 WO PCT/JP2005/001172 patent/WO2005071102A2/en active Application Filing
- 2005-01-21 US US10/586,987 patent/US8221993B2/en not_active Expired - Fee Related
- 2005-01-21 EP EP05704225A patent/EP1718761B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| JP4614954B2 (ja) | 2011-01-19 |
| EP1718761A2 (de) | 2006-11-08 |
| EP1718761B1 (de) | 2009-01-21 |
| WO2005071102A2 (en) | 2005-08-04 |
| CA2554053A1 (en) | 2005-08-04 |
| US8221993B2 (en) | 2012-07-17 |
| DE602005012483D1 (de) | 2009-03-12 |
| CN1954082B (zh) | 2011-08-17 |
| WO2005071102A3 (en) | 2005-11-17 |
| KR20060129025A (ko) | 2006-12-14 |
| TW200533920A (en) | 2005-10-16 |
| JP2007519391A (ja) | 2007-07-19 |
| TWI350373B (en) | 2011-10-11 |
| CN1954082A (zh) | 2007-04-25 |
| ES2321527T3 (es) | 2009-06-08 |
| US20090035303A1 (en) | 2009-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE421596T1 (de) | Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität | |
| TW200741009A (en) | Methods of modulating SMYD3 for treatment of cancer | |
| ATE416786T1 (de) | Verfahren zur behandlung von dickdarmkrebs mit botulinum neurotoxin | |
| IL179514A0 (en) | Method of administering and using vegf inhibitors for the treatment of malignant pleural effusion | |
| DE602006012650D1 (de) | Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung | |
| ATE463162T1 (de) | Verfahren zur verstärkung der wirksamkeit von ethaboxam | |
| DE602005011097D1 (de) | Verfahren zur modulierung von hintergrund- und vordergrundregionen | |
| DE602005004280D1 (de) | Verfahren zum ziehen von sic-einkristallen und sic-einkristall | |
| DE69918089D1 (de) | Btk inhibitoren und verfahren zur identifizierung und verwendung | |
| DE60104392D1 (de) | Verfahren zum nachweis der effektivität einer krebstherapie | |
| AT9258U3 (de) | Transdermal-pflaster zum verabreichen von fentanyl | |
| DE60309299D1 (de) | System und Verfahren zur Ablaufverfolgung von Banknoten | |
| ATE440604T1 (de) | Verfahren zum evaluieren und behandeln von krebs | |
| DE502005003829D1 (de) | Vorrichtung und Verfahren zur kapazitiven Vermessung von Materialien | |
| ATE422162T1 (de) | Verfahren zur vorhersage und verhinderung der resistenz gegen taxoid-verbindungen | |
| ATE397098T1 (de) | Verfahren zur diagnostik von eierstock endometriose | |
| DK1893213T3 (da) | Kombination af pyrimidylaminobenzamidforbindelser og imatinib til behandling eller forebyggelse af proliferative sygdomme | |
| DE602006019733D1 (de) | Verfahren und zusammensetzungen zur notfallbedingten verhütung mithilfe von endothelin-rezeptor-antagonisten | |
| DE502005008526D1 (de) | Verfahren zur Prüfung der Dichtigkeit von Behältern | |
| DE112005002656A5 (de) | Verfahren zum verzugsarmen Einsatzhärten von metallischen Bauteilen | |
| FI20021565A0 (fi) | Menetelmä ja järjestelmä teräksen karkaisusyvyyden määrittämiseksi | |
| ATE543429T1 (de) | Verfahren zur bestimmung des sympathikus-tonus und messsystem dafür | |
| DE502004010623D1 (de) | Hydrodynamische kupplung und verfahren zur beeinflussung des von der hydrodynamischen kupplung aufnehmbaren momentes | |
| DE102020100667A8 (de) | Verfahren zum Anpassen von Sicherheitsbereichen | |
| ATE297989T1 (de) | Verbindungen und verfahren zur änderung der genexpression |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |