1313593 九、發明說明： 【發明所屬之技術領域】 本發明係關於一種心電訊號收集裝置，特別是關於一種 微型無線（wireless)心電訊號收集裝置。 【先前技術】 圖1係例示一心跳之心電圖（electrocardiogram ; ECG)訊 號’一般而言將其最尖端的波段稱為QRS波，其中首先向 上偏折的點為Q點，在頂端為R點，而最後於底端處稱為S 點。於QRS辨認程序中首先以尖峰檢測程序將心電訊號中 的QRS波找出，且從每個QRS波中測量其高度（amplitude) 和持續時間（duration)等參數，並將各參數之平均值和標準 差算出，用以作為標準模版。接下來每個QRS波都以此模 版進行比對。 心率變異性（heart rate variability ; HRV)分析是從心跳週 期數列分析心臟生理功能的方法，標準的分析程序已在 1996由歐美心臟學會所定義（Task F〇rce 〇f the Eur〇pean Society of Cardiology and the North American Society of Pacing and Electrophysiology，1996)，之後經過一些修改 (Kuo et al.，1999)，大致原理如下： 1.首先取得心跳週期的資訊，大部份的作法是從心電圖的 R波定義每一心跳的發生，而每一 R波與後一個R波的時 間差就是一個心跳週期RR。 2_如果連續的RR數列中有大幅度的變動’譬如超過三個標 準差，可能是心率不整或是雜訊。若是前者，應立即提 105311發明專利說明書.d〇c 1313593 出警訊，因受測者的生命可能受到威脅；若是後者，應 改良測量分析的技術以克服之。 3 ·如果連續的RR數列中沒有大幅的變動，則這些RR數列 可進行更細緻的數值分析，包括頻譜分析（Kuo et al.， 1999)與非線性分析（Kuo & Yang, 2002)等。 藉由頻譜分析的協助，研究人員發現心率變異度中微 小的波動可明確的分為兩群，一般稱為高頻 (high-frequency ; HF)和低頻（low-frequency ; LF)成份。高頻成 分和動物的吟吸訊號同步，所以又可稱為呼吸成份，其 於人體約3秒一次。低頻成分則來源不明，推測可能和 血管運動或感壓反射有關，其於人體約10秒一次。部份 學者更進一步將該低頻成分細分為極低頻（very low frequency，VLF)和低頻成份。目前已有許多生理學家與心 臟科醫師同意心率的高頻成分或總變異度（total power ; TP) 能代表副交感神經功能，而低頻成份和高頻成份之比值 (LF/HF)能反應交感神經的活性。從RR週期的頻譜中，吾 人可以得到許多心臟神經調節的資訊，對許多疾病的診斷 與養生保健都很有幫助。因此HRV分析被許多學者視為非 常有潛力的診斷技術，目前已證實在加護病房的生死預測 (Yien et al_，1997)、心肌梗塞的追蹤治療及糖尿病自主神經 病變的篩檢上有明確的應用價值（Task Force of the139. The invention relates to an electrocardiographic signal collecting device, and more particularly to a miniature electrocardiographic signal collecting device. [Prior Art] FIG. 1 illustrates an electrocardiogram (ECG) signal of a heartbeat. Generally speaking, the most advanced band is called a QRS wave, wherein the point of the first upward deflection is the Q point, and the top point is the R point. Finally, it is called the S point at the bottom. In the QRS identification process, the QRS wave in the ECG signal is first found by the spike detection program, and the parameters such as altitude and duration are measured from each QRS wave, and the average of each parameter is obtained. And standard deviation calculation, used as a standard template. Each QRS wave is then compared against this template. Heart rate variability (HRV) analysis is a method for analyzing cardiac physiological functions from a series of heartbeat cycles. The standard analytical procedure was defined in 1996 by the European Society of Cardiology (Task F〇rce 〇f the Eur〇pean Society of Cardiology). And the North American Society of Pacing and Electrophysiology, 1996), after some modifications (Kuo et al., 1999), the general principles are as follows: 1. First get the information of the heartbeat cycle, most of the practice is from the R wave of the ECG Define the occurrence of each heartbeat, and the time difference between each R wave and the next R wave is a heartbeat period RR. 2_ If there is a large change in the continuous RR series, such as more than three standard deviations, it may be heart rate irregularities or noise. In the case of the former, the 105311 invention patent specification should be immediately filed. d〇c 1313593 A warning is issued, because the life of the subject may be threatened; if the latter, the technique of measurement analysis should be improved to overcome it. 3 • If there are no large changes in the continuous RR series, these RR series can perform more detailed numerical analysis, including spectrum analysis (Kuo et al., 1999) and nonlinear analysis (Kuo & Yang, 2002). With the help of spectrum analysis, the researchers found that small fluctuations in heart rate variability can be clearly divided into two groups, commonly referred to as high-frequency (HF) and low-frequency (LF) components. The high frequency component is synchronized with the animal's sucking signal, so it can also be called a breathing component, which is about 3 seconds in the human body. The source of the low-frequency component is unknown, and it is speculated that it may be related to vascular motion or pressure-sensitive reflex, which is about 10 seconds in the human body. Some scholars further subdivide the low frequency components into very low frequency (VLF) and low frequency components. Many physiologists and cardiologists have agreed that the high frequency component or total variability (total power; TP) of the heart rate can represent parasympathetic function, while the ratio of low frequency component to high frequency component (LF/HF) can reflect sympathetic Nerve activity. From the spectrum of the RR cycle, we can get a lot of information about cardiac neuromodulation, which is helpful for the diagnosis and health care of many diseases. Therefore, HRV analysis is regarded by many scholars as a very promising diagnostic technique, and it has been confirmed that there is a clear application in the life and death prediction of the intensive care unit (Yien et al_, 1997), the follow-up treatment of myocardial infarction, and the screening of diabetic autonomic neuropathy. Value (Task Force of the
European Society of Cardiology and the North American Society of Pacing and Electrophysiology, 1996)。在睡目民研 究的應用則是另一個新興的發展方向（Kuo & Yang，2005>。 105311發明專利說明書.doc 1313593 HRV分析目前最常用的訊號來源是心電圖，因為尖銳的R 波提供一個精確的時間測量點。然而目前大家熟知的心電 測量法’譬如完整的12導程心電圖’需在受測者身上連接 許多電線’受測時不能亂動，不但接線耗時，也造成受測 者的不便與不悅。比㈣化的作法是只接上-個頻道的心 電圖，但仍要在受測者身上接上二至三條電線，還是不方 便’也無法讓受測者自由活動。近年來，隨著科技的進步 已有人研發出更小型的心電儀，這些所謂「隨身型 (ambulatory)」的心電儀大小約如手掌，有些可以將連續的 心電訊號儲存在内部的記憶體（包括磁性媒介）中，有些甚至 可以即時將心、電訊號以無線電波或紅外線傳輸到遠方的接 收器中，讓外界可以即時獲知受測者的身體狀況，這些技 術,HRV的應用更加方便而有彈性u這些儀器的體積 還是太大’重量較太重，尤其是接線的方式對—般未受 訓者來說還是太複雜。這些電線雖然已經較短，但仍會造 成使用者的-些不便。所以目前這些「隨身型」的心電儀 基本上還是屬於醫療儀^ ’需要專家❹料才能正確配 戴，仍不是一般人可以自由使用的消耗性電子產品。 若想將HRV技術更廣泛的推廣到每一個家庭與個人，必 須克服目前各類@]定式或攜帶式^電儀的種種不便，微小 化與徹底的無線化將是必然的發展方向。 【發明内容】 為達到上述之目的與避免習知的問題，本發明揭示一種 微型如紐扣大小、利用無線傳輪的心電訊號收集裝置，以 105311發明專利說明書.d〇c 1313593 利HRV各類的分析。本發明之微型無線心電訊號收集裝置 可直接黏貼於受測者胸前，不僅輕盈便利，且受測者不需 受到傳統連接電線之牽綷，有助於將HRV技術廣泛地推廣 應用於家庭與個人。 該微型無線心電訊號收集裝置操作包含一電極 (electrode)、一 放大器（amplifier)模組、一微控制器（micr〇 controller)、一無線電模組與一電源供應器。 該電極為為一具有正電極與負電極之雙極差分設計，用 以收集受測者的心電訊號。該放大器模組接收來自該正電 極與負電極的雙極輸入訊號後’先經由一輸入級濾波器濾 除雜訊以增加訊说雜訊比（signal t〇 noise ratio)，再經由一 差分放大器進行差分放大’產生一放大心電訊號。該放大 心電訊號再經由一輸出級濾波器排除該微控制器之類比數 位取樣兩倍頻率以上之訊號，以利該微控制器之類比數位 取樣。該微控制器之類比數位轉換單元以適當的電壓解析 度與取樣率將來自該放大器模組產生的放大心電訊號做類 比至數位轉換’再以一微處理運算單元進行資料壓縮，產 生一數位心電訊號。該無線電模組接收來自微控制器產生 的數位心電訊號，經一調變/解調變器（m〇dulat〇r/de modulator)調變為一調變心電訊號，該調變心電訊號經一無 線收發器以一無線心電訊號發射至遠端。同時該無線電模 組也可以該無線收發器接收來自遠端的無線訊號。 隨著半導體技術的進步，本發明之微型無線心電訊號收 集裝置具備進一步縮小化的潛力，可將電極、放大器模組、 1〇5311發明專利說明書.doc 1313593 微控制器、無線電模組與電源供應器的所有電路整合到— 片電路板，甚至是一顆晶片（chip)内，依此本發明可實現可 拋棄式（disposable)無線心電電訊號收集裝置之構想，對於 感染性或一些特殊性的應用有其重要性。 【實施方式】 圖2係本發明一實施例之微型無線心電訊號收集裝置2 〇 之方塊示意圖。該微型無線心電訊號裝置2〇包含一電極 > 201、一放大器模組202、一微控制器203、一無線電模組2〇4 與一電源供應器205。 電極201為為一具有正電極20la與負電極20lb之雙極差 分設計，可直接連接到受測者200身上，用以收集受測者2〇〇 的心電訊號。 該放大器模組202包含一對輸入級濾波器202a、一差分放 大器202b與一輸出級濾波器202c。該放大器模組202接收來 自該正電極201 a與負電極201 b的雙極輸入訊號後，先經由 .該輸入級濾波器202a濾除雜訊以增加訊號雜訊比，再經由 , 該差分放大器202b進行差分放大，產生一放大心電訊號。 該差分放大器202b—方面將共模（common mode)之雜訊衰 減，另一方面將差異（differential)之心電訊號以適當的倍率 放大，以配合該微控制器203之類比數位轉換的電壓範圍。 該放大心電訊號再經由該輸出級濾波器202c排除奈奎斯頻 率（Nyquist frequency)(即該微控制器之類比數位轉換中取 樣頻率的兩倍）以上之訊號，以利該微控制器203之類比數 位取樣。此外’該放大器模組202之輸入端阻抗大於200k 105311發明專利說明書.doc 1313593 Ω，以避免錯誤動作可能產生的漏電。該輸入級濾波器 202a、輸出級濾波器2〇2c可由電阻與電容類被動元件構 成’該差分放大器202b可由積體電路式之運算放大器或儀 測放大器構成。 該微控制器203包含一類比數位轉換單元2〇3a與一微處 理運算單元203b。該類比數位轉換單元2〇3a以適當的電壓 解析度與取樣率將來自該放大器模組2〇2產生的放大心電 訊號做類比至數位轉換’再以該微處理運算單元2〇3b進行 資料壓縮’產生一數位心電訊號。 該無線電模組204包含一無線收發器2〇4a與一調變/解調 變器204b ’該無線電模組2〇4與微控制器203相連的輸入端 為串列式或並列式之數位通道，接收來自微控制器2〇3產生 的數位心電訊號’並經該調變/解調變器2〇4b調變為以 2.4GHz為載波（carrier)之調變心電訊號。該調變心電訊號經 該無線收發器204a以一無線心電訊號發射至遠端；同時該 無線收發器204a亦可接收來自遠端的無線訊號，再經該調 變/解調變器204b解調變為數位資料訊號後，再經該數位通 道傳給微控制器203。來自遠端的無線訊號包含該無線心電 訊號收集裝置20的控制訊號與遠方接收器所發出的確認 (acknowledge)訊號。該確認訊號的應用例如：來自該微控 制器203經資料壓縮並加上適當的標記後的數位心電訊 號’以數位通道傳送到該無線電模組204進行無線心電訊號 的發射輸出，透過接收遠方接收器所發出的確認訊號，可 確保無線心電訊號資料輸出的完整。該無線電模組204以國 105311發明專利說明書.doc -10- 1313593 際標準之工業、科學、醫療（Industry Science Medical; ISM) 專用之的2.4GHz頻段進行無線電發射與接收。 電源供應器205可為一微型電池或一太陽能電源，用以提 供該微型無線心電訊號收集裝置20内所有電路的電源。 圖3(a)、圖3(b)與圖3(c)所示係根據本發明之實施例之微 型無線心電收集裝置結構分解示意圖。 圖3(a)所示為一多層電路板構造，分為電路板層3〇1、3 〇2 和3 03三層，每一層均包含一上表面與一底表面，微控制器 丨 203與無線電模組204配置於電路板層301上表面，放大器模 組2 02配置於電路板層302上表面，電極201配置於電路板層 303底表面。無線電模組2〇4配置於最上層之電路板層3〇1 有助於無線訊號的發射與接收。由於電路板層3〇1的微控制 器203與無線電模組204電路可能干擾位於電路板層3〇2層 之放大器模組202的訊號，在電路板層3〇1的底表面加上一 層隔離接地面301a，將有助位於電路板層3〇2的放大器模組 丨 202提高其類比線路之訊號雜訊比。電源供應器2〇5可配置 於電路板層302底表面與電路板層3〇3上表面之間，電路板 層3 02的底表面可直接接觸到電源供應器2〇5上的正或負其 中一極作為電源層，而電路板層3〇3的上表面可直接接觸到 電源供應器205的另一極作為另一電源層。所有圖3(勾所示 線路可縮小在直徑2公分（cm)，高度〇·5公分（cm)之鈕扣式微 型結構内，如圖3(d)所示。 隨著半導體技術的進步，可將電路板層3〇1和兩層上 之το件202、203和204合併於同一電路板層311中，電極2〇ι 105311發明專利說明書.doc 1313593 則配置於電路板層312底表面，如圖3(b)所示。此外，甚至 電路板層301、302和303中之元件202、203、204和205可進 一步合併於同一電路板層321中，據此電路板層321上表面 的所有元件202、203、204和205可以整合到一顆晶片内， 如圖3(c)所示。 電源供應器205可如圖3(a)所示置於電路板層303與302之 間’或如圖3(b)所示置於電路板層3 12與3 11之間，其將有助 於電極201隔離來自微控制器203與無線電模組2〇4電路的 干擾電波’另一方面將電源供應器205置於較下層有助於整 體重心的降低’增加該微型無線心電訊號收集裝置2〇與受 測人體黏合的穩定性。 電路板層303、312和321底表面的電極201，可因應用的 實際需要進行各類的設計，在心電圖的應用中，可設計為 由印刷線路板的單面構成，如圊4(a)所示的同心圓型電極或 如圖4(b)所示的半圓型電極’經由適當的導電膠質黏合受測 面產生導電接觸，以收集雙極的電訊號。 圖5為本發明之微型無線心電訊號收集裝置所收集之心 電訊號，透過無線電模組傳輸後於接收端電腦上所展示的 波型，其中心電訊號取樣頻率為5 12Hz，電壓解析度為8位 元。 圖6所示係利用本發明之微型無線心電訊號收集裝置收 集五分鐘之心電訊號來進行HRV之頻域分析。該無線心電 訊號裝置之電極雙端接上受測者，以每秒512 Hz之取樣速 度收集五分鐘心電訊號，並立即進行HRV頻域分析，由圖6 -12- I053H發明專利說明書.d〇l 1313593 可見該受試者之心率變異頻譜明確區分為高頻 HF(0.15-0.4Hz)與低頻 LF(0.04-0.15Hz)成份。 本發明之技術内容及技術特點已揭示如上，然而熟悉本 項技術之人士仍可能基於本發明之教示及揭示而作種種不 背離本發明精神之替換及修飾。因此，本發明之保護範圍 應不限於實施例所揭示者，而應包括各種不背離本發明之 替換及修飾，並為以下之申請專利範圍所涵蓋。 【圖式簡單說明】 圖1係例示一心跳之心電圖訊號； 圖2係根據本發明之實施例之微型無線心電訊號收集襄 置方塊示意圖； 圖3(a)、圖3(b)與圖3(c)所示係根據本發明之實施例之微 型無線心電收集裝置結構分解示意圖； 圖3(d)所示係根據本發明之實施例之微型無線心電訊號 收集裝置之鈕扣式微型結構； 圖4(a)及4(b)係根據本發明之實施例之電極示意圖； 圖5所示係本發明之微型無線心電訊號收集裝置所收集 之心電訊號；以及 圖6例示本發明之微型無線心電訊號收集裝置所得之 HRV之頻域分析圖。 【主要元件符號說明】 20 無線心電訊號收集裝置 200 受測者 201 電極 201a 正電極 201b 負電極 105311發明專利說明書.doc 1313593 202 放大器模組 202a 輸入級濾波器 202b 差分放大Is 202c 輸出級濾波器 203 微控制器 203a 類比數位轉換單元 203b 微處理運算單元 204 無線電模組 204a 無線收發器 204b 調變/解調變器 205 電源供應器 301、 302 、 303 、 311 、 312 、 321 電路板層 301a 隔離接地面European Society of Cardiology and the North American Society of Pacing and Electrophysiology, 1996). The application of sleep-watching research is another emerging development direction (Kuo & Yang, 2005). 105311 invention patent specification. doc 1313593 The most commonly used signal source for HRV analysis is the electrocardiogram, because the sharp R-wave provides an accurate The time measurement point. However, the well-known ECG method, such as a complete 12-lead ECG, requires a large number of wires to be connected to the subject. 'It cannot be tampered when tested. It is not only time-consuming but also causes the subject to be tested. The inconvenience and dissatisfaction. Compared with the (four) method, only the electrocardiogram of one channel is connected, but it is still inconvenient to connect two or three wires to the subject, and the subject is free to move. Come, with the advancement of technology, people have developed smaller electrocardiographs. These so-called "ambulatory" electrocardiographs are about the size of palms, and some can store continuous ECG signals in internal memory. Some of them (including magnetic media) can even transmit the heart and electric signals to distant receivers by radio waves or infrared rays, so that the outside world can know immediately The physical condition of these subjects, these techniques, the application of HRV is more convenient and flexible. The size of these instruments is still too large. The weight is too heavy, especially the way of wiring is too complicated for untrained people. These wires Although it is already short, it still causes some inconvenience to the users. Therefore, these "push-type" electrocardiographs are basically medical devices. 'Requires expert advice to properly wear them. It is still not free for ordinary people to use. Consumable electronic products. If you want to promote HRV technology to every family and individual, you must overcome the inconveniences of various types of current or portable electric devices. Miniaturization and thorough wirelessization will be inevitable. In order to achieve the above objects and avoid the conventional problems, the present invention discloses a miniature electrocardiographic signal collecting device using a wireless transmission wheel, such as a button size, to 105311 invention patent specification. d〇c 1313593 Analysis of various types of HRV. The micro wireless ECG signal collecting device of the present invention can be directly attached to the chest of the subject, which is not only light and convenient, but also The subject does not need to be tied to the traditional connecting wires, which helps to widely apply HRV technology to families and individuals. The micro-wireless ECG signal collecting device operates including an electrode and an amplifier module. A microcontroller (micr〇controller), a radio module and a power supply. The electrode is a bipolar differential design having a positive electrode and a negative electrode for collecting the electrocardiogram of the subject. The amplifier module receives the bipolar input signal from the positive electrode and the negative electrode and then filters the noise through an input stage filter to increase the signal t〇noise ratio, and then passes through a differential amplifier. Performing differential amplification 'generates an amplified ECG signal. The amplified ECG signal then rejects the analog signal of the analog controller by more than twice the frequency via an output stage filter to facilitate analog digital sampling of the microcontroller. The analog digital conversion unit of the microcontroller analogizes the amplified ECG signal generated by the amplifier module to digital conversion with appropriate voltage resolution and sampling rate, and then performs data compression by a micro processing unit to generate a digital position. ECG signal. The radio module receives the digital ECG signal generated by the microcontroller, and is modulated into a modulated ECG signal by a modulation/demodulation transformer (m〇dulat〇r/de modulator), and the modulated ECG signal is modulated. A wireless transceiver transmits to the remote end with a wireless ECG signal. At the same time, the radio module can also receive wireless signals from the far end by the wireless transceiver. With the advancement of semiconductor technology, the micro-wireless ECG signal collecting device of the present invention has the potential to further reduce the size, and can be used for electrodes, amplifier modules, patent specifications, doc 1313593 microcontroller, radio module and power supply. All the circuits of the supplier are integrated into a chip board or even a chip. According to the present invention, the concept of a disposable wireless ECG collecting device can be realized, for infectivity or some particularity. The application has its importance. [Embodiment] FIG. 2 is a block diagram showing a micro wireless electrocardiographic signal collecting device 2 according to an embodiment of the present invention. The micro wireless ECG device 2 includes an electrode > 201, an amplifier module 202, a microcontroller 203, a radio module 2〇4, and a power supply 205. The electrode 201 is designed as a bipolar difference having a positive electrode 20la and a negative electrode 20lb, and can be directly connected to the subject 200 for collecting the electrocardiogram of the subject. The amplifier module 202 includes a pair of input stage filters 202a, a differential amplifier 202b and an output stage filter 202c. After receiving the bipolar input signal from the positive electrode 201 a and the negative electrode 201 b, the amplifier module 202 first filters the noise through the input stage filter 202a to increase the signal noise ratio, and then passes the differential amplifier. 202b performs differential amplification to generate an amplified ECG signal. The differential amplifier 202b attenuates the noise of the common mode, and on the other hand amplifies the differential ECG signal at an appropriate magnification to match the voltage range of the digital conversion of the microcontroller 203. . The amplified ECG signal further excludes a signal above the Nyquist frequency (ie, twice the sampling frequency in the analog digital conversion of the microcontroller) via the output stage filter 202c to facilitate the microcontroller 203. Analogous to digital sampling. In addition, the impedance of the input terminal of the amplifier module 202 is greater than 200k 105311 invention patent specification.doc 1313593 Ω to avoid leakage caused by malfunction. The input stage filter 202a and the output stage filter 2〇2c may be constituted by a resistor and a capacitor-like passive element. The differential amplifier 202b may be constituted by an integrated circuit type operational amplifier or a sense amplifier. The microcontroller 203 includes an analog-to-digital conversion unit 2〇3a and a micro-processing unit 203b. The analog-to-digital conversion unit 2〇3a analogizes the amplified electrocardiogram generated by the amplifier module 2〇2 to digital conversion with appropriate voltage resolution and sampling rate, and then performs data by the micro processing unit 2〇3b. Compression 'generates a digital ECG signal. The radio module 204 includes a wireless transceiver 2〇4a and a modulation/demodulation transformer 204b. The input terminal of the radio module 2〇4 and the microcontroller 203 is a serial or side-by-side digital channel. The digital electrocardiogram generated by the microcontroller 2〇3 is received and modulated by the modulation/demodulation transformer 2〇4b into a modulated ECG signal with a carrier of 2.4 GHz. The modulated ECG signal is transmitted to the remote end via the wireless transceiver 204a by a wireless ECG signal; and the wireless transceiver 204a can also receive the wireless signal from the remote end, and then the solution is decoded by the modulation/demodulation transformer 204b. After being converted into a digital data signal, it is transmitted to the microcontroller 203 via the digital channel. The wireless signal from the far end includes the control signal of the wireless ECG collecting device 20 and an acknowledge signal sent by the remote receiver. The application of the confirmation signal is as follows: the digital ECG signal from the microcontroller 203 is compressed by the data and appropriately labeled, and transmitted to the radio module 204 by the digital channel for transmitting and outputting the wireless ECG signal through the receiving. The confirmation signal from the remote receiver ensures the integrity of the wireless ECG signal output. The radio module 204 performs radio transmission and reception in the 2.4 GHz band dedicated to the Industrial, Scientific, and Medical (ISM) standard of the National Patent No. 105311. The power supply 205 can be a micro battery or a solar power source for providing power to all circuits in the micro wireless ECG signal collection device 20. 3(a), 3(b) and 3(c) are schematic exploded views showing the structure of a micro-wireless electrocardiograph according to an embodiment of the present invention. Figure 3 (a) shows a multi-layer circuit board structure, divided into three layers of circuit board layers 3 〇 1, 3 〇 2 and 303 , each layer including an upper surface and a bottom surface, the microcontroller 丨 203 The radio module 204 is disposed on the upper surface of the circuit board layer 301, the amplifier module 022 is disposed on the upper surface of the circuit board layer 302, and the electrode 201 is disposed on the bottom surface of the circuit board layer 303. The radio module 2〇4 is disposed on the uppermost circuit board layer 3〇1 to facilitate the transmission and reception of wireless signals. Since the microcontroller 203 and the radio module 204 circuit of the board layer 3〇1 may interfere with the signal of the amplifier module 202 located at the layer 3 of the board layer, a layer of isolation is added to the bottom surface of the board layer 3〇1. The ground plane 301a will help the amplifier module 202 at the board layer 3〇2 to increase the signal-to-noise ratio of its analog line. The power supply 2〇5 can be disposed between the bottom surface of the circuit board layer 302 and the upper surface of the circuit board layer 3〇3, and the bottom surface of the circuit board layer 302 can directly contact the positive or negative power supply 2〇5. One of the poles serves as a power supply layer, and the upper surface of the circuit board layer 3〇3 can directly contact the other pole of the power supply 205 as another power supply layer. All Figure 3 (the line shown in the hook can be reduced in a button-type microstructure with a diameter of 2 cm (cm) and a height of 5 5 cm (cm), as shown in Figure 3 (d). With the advancement of semiconductor technology, The circuit board layer 3〇1 and the το pieces 202, 203 and 204 on the two layers are combined in the same circuit board layer 311, and the electrode 2〇ι 105311 invention patent specification.doc 1313593 is disposed on the bottom surface of the circuit board layer 312, such as Figure 3(b). Furthermore, even the elements 202, 203, 204 and 205 of the circuit board layers 301, 302 and 303 can be further incorporated in the same circuit board layer 321, whereby all of the upper surface of the circuit board layer 321 Elements 202, 203, 204, and 205 can be integrated into a single wafer, as shown in Figure 3(c). Power supply 205 can be placed between circuit board layers 303 and 302 as shown in Figure 3(a). Placed between the board layers 3 12 and 3 11 as shown in Figure 3(b), which will help the electrode 201 isolate the interfering waves from the microcontroller 203 and the radio module 2〇4. The power supply 205 is placed on the lower layer to contribute to the reduction of the overall center of gravity. Increasing the micro-wireless ECG collecting device 2 and the subject The stability of the bonding. The electrodes 201 on the bottom surfaces of the circuit board layers 303, 312 and 321 can be designed according to the actual needs of the application. In the application of the electrocardiogram, it can be designed to be composed of one side of the printed circuit board, such as The concentric circular electrode shown in 圊4(a) or the semi-circular electrode shown in Fig. 4(b) is electrically contacted via a suitable conductive paste-bonded test surface to collect bipolar electrical signals. The ECG signal collected by the micro-wireless ECG signal collecting device of the present invention is transmitted through the radio module and displayed on the receiving end computer with a center electric signal sampling frequency of 5 12 Hz and a voltage resolution of 8 bits. Figure 6 shows the frequency domain analysis of the HRV using the micro-wireless ECG signal collecting device of the present invention to collect the five-minute ECG signal. The electrode of the wireless ECG device is connected to the subject at both ends. A five-minute ECG signal was collected at a sampling rate of 512 Hz per second, and the HRV frequency domain analysis was performed immediately. The subject's heart rate variability spectrum was clearly distinguished as high by the 6.4- -12- I053H invention patent specification. d〇l 1313593 frequency HF (0.15-0.4 Hz) and low frequency LF (0.04-0.15 Hz) components. The technical content and technical features of the present invention have been disclosed above, but those skilled in the art may still make various kinds based on the teachings and disclosures of the present invention. The present invention is not intended to be limited to the details of the invention, and the invention is intended to be limited by the scope of the invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram showing a heartbeat signal of a heartbeat; FIG. 2 is a block diagram of a micro-wireless ECG signal collecting device according to an embodiment of the present invention; FIG. 3(a), FIG. 3(b) and FIG. c) is a schematic exploded view of a miniature wireless ECG collecting device according to an embodiment of the present invention; and FIG. 3(d) shows a button-type microstructure of a miniature wireless ECG signal collecting device according to an embodiment of the present invention; 4(a) and 4(b) are schematic views of electrodes according to an embodiment of the present invention; FIG. 5 is an electrocardiogram signal collected by the micro wireless electrocardiographic signal collecting device of the present invention; and FIG. 6 illustrates the present invention. miniature A frequency domain analysis map of the HRV obtained by the wireless ECG signal collection device. [Main component symbol description] 20 Wireless ECG signal collecting device 200 Subject 201 Electrode 201a Positive electrode 201b Negative electrode 105311 Invention patent specification. Doc 1313593 202 Amplifier module 202a Input stage filter 202b Differential amplification Is 202c Output stage filter 203 Microcontroller 203a Analog-to-digital conversion unit 203b Micro-processing unit 204 Radio module 204a Wireless transceiver 204b Modulation/demodulation transformer 205 Power supply 301, 302, 303, 311, 312, 321 Circuit board layer 301a isolation Ground plane
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