TWI232972B - Oxygen-permeable hard contact lenses - Google Patents

Abstract

The invention provides a kind of oxygen-permeable hard contact lens which comprises: a polymer having an oxygen permeability of more than 20x10<-11> cm<3>.cm/cm<2>.sec.mmHg. The center thickness of the lens is 0.010 to 0.125 mm, and the vertex power is over -6.00 D. It is capable of supplying sufficient oxygen to a cornea physiologically and excellent in durability.

Description

1232972 玖 发明, description of the invention (the description of the invention should state: the technical field to which the invention belongs, the prior art, the content, the embodiments, and the drawings briefly) Purpose of the invention The present invention relates to an oxygen-permeable rigid contact lens. The oxygen-permeable rigid contact lens of the present invention not only has a thin center thickness of the lens, but also has superior safety to the cornea's high oxygen supply capacity, and can reduce damage and durability during use. Back view technology Because the invisible eye is known as a vision corrector used in direct contact with the eye (cornea), it must have superior optical characteristics and be fully safe for it.

Necessary conditions. The cornea is a bloodless tissue and is dynamic. The development of materials from the supply of oxygen in the atmosphere is non-aerobic. The result is a variety of contact lens materials and contact lenses. The proposed dream-containing styrene derivatives and inclusions are essential ophthalmic lens materials. In order to maintain the metabolic activity of corneal cells. Here, in order to improve the permeability, we have developed a styrene derivative with a high oxygen permeability coefficient such as that described in JP 6-4 1242. However, in the past, the high oxygen permeability system has reduced impact and point. As its oxygen permeability changes, &lt; breaks the strength, the lens is easy to break

In order to improve the method as described above, the contact lens is better than that of JP-A-Heisei 11-3 14283. Its strength, but failed to achieve the lens in the lens wear and tear situation. In the former case, &amp; a kind of conventional lens JJ-5 which manufactures oxygen-permeable contact lenses, the contact lenses obtained by compressive destruction strength and difficult to break 'this' can improve the durability. In particular, when it has a scar, it is damaged by A vata hardening, resulting in damage. 1232972 _ m Description of the Invention Continued The present invention is an object invented based on the above-mentioned prior art, and its purpose is to provide a transparent Oxygen rigid contact lenses can supply physiologically sufficient oxygen to the cornea, and have superior durability. The invention discloses that the present invention relates to an oxygen-permeable rigid contact lens, which comprises a polymer having an oxygen permeability coefficient of 20 X lOAcm ^ cm / cmhsec.mmHg or more, and an apex refractive power characterized by a lens center thickness of 0.010-0.125 mm is -Above 6.00D.

The best mode for carrying out the invention The oxygen-permeable rigid contact lens of the present invention has a lens center thickness in the range of 0.010-0.125 mm and a vertex refractive power value of -6.00D or more.

In this specification, the "center thickness of the lens" refers to the thickness of the center portion (optical center) of the optical portion of the lens, and the "apex refractive power value" refers to the refractive power of the lens. In the case of a spherical lens, the value of the refractive power at the vertex becomes smaller, and the curvature difference between the front and rear of the lens becomes larger, which inevitably makes the thickness of the peripheral portion of the lens larger. Therefore, in order to reduce the thickness of the entire lens, even if the center thickness is reduced, the strength of the lens can be maintained by the thickness of the peripheral portion. On the other hand, as the value of the refractive power of the vertex becomes larger, the difference in curvature between the front and back of the lens becomes smaller. If the center thickness is reduced in order to reduce the overall thickness of the lens, the thickness of the peripheral portion is also reduced, resulting in a reduction in lens strength. . Therefore, in general, an oxygen-permeable invisible eyepiece lens with a vertex refractive index of -6.00D or more has a center thickness of 0.150 mm or more from the viewpoint of strength. The present invention focuses on the thickness of the center of the lens, and finds that the oxygen permeability coefficient is 20 and 10'11 (: 〇13 (3 丁?) * *:: 〇1 / (: 1112 * 56 (: * 1111111 ^ or more) When the center thickness of the formed contact lens is set in the above range, it does not cause the problem of insufficient strength as in the actual use of 1232972 (3) Invention. It is better to make it easier to bend the lens and to disperse the stress. Improving the durability of the lens repeatedly stressed (durability under practical conditions).

When the thickness of the lens center exceeds 0.125 mm, the rigidity of the lens becomes high and the stress is concentrated in the place where there is a lot of bending (where the stress is weaker), which reduces the durability against repeated changes in stress. When the center thickness of the lens is less than 0.010 mm, the ability to maintain the shape of the lens is reduced, which reduces the vision correction ability. From the viewpoint of vision correction ability and durability against repeated changes in stress, the lens center thickness is preferably in the range of 0.050-0.120 mm, and more preferably in the range of 0.070-0.105 mm.

In the oxygen-permeable rigid contact lens of the present invention, from the viewpoint of vision correction ability and durability against repeated changes in stress, the Vickers hardness of the lens is an indicator of the bendability (rigidity of the lens) of 5 A range of -15 is preferable, and a range of 5-10 is more preferable. From the same point of view, the compression elasticity of the oxygen-permeable rigid contact lens of the present invention is preferably in the range of 10-100 gf, and more preferably in the range of 20-90 gf. The compressive elastic modulus is an index of the flexibility of the lens. The smaller the value, the easier the lens is to bend, and the larger the value, the higher the rigidity of the lens. The oxygen permeability coefficient of the polymer using the oxygen-permeable rigid contact lens of the present invention is 20X 10_ucm3 * cm / cm2esec * mmHg or more. As used herein, the "oxygen permeability coefficient" is expressed as the product of the oxygen solubility coefficient of the polymer and the diffusion coefficient of oxygen in the polymer. Specifically, it refers to the "rigid contact lens" by the standard measurement method of the Contact Lens Association. "Measurement of oxygen permeability". Ϊ232972 _ (4) I Description of the invention Continued page Permanent compound oxygen permeability coefficient is less than 20 X 1〇_ 丨 cm3 * cm / cm2 * sec * mmHg, the corneal physiologically sufficient oxygen cannot be supplied, and Insufficient corneal oxygen can cause eye problems. In addition, when the oxygen permeability coefficient of the polymer is increased, the pollution resistance tends to be lowered. Therefore, from the viewpoint of lens oxygen permeability and stain resistance, the polymer's oxygen permeability coefficient is preferably in the range of 20 × 10′-200 × 10-ncm, cm / cm2 * sec.mmHg. , 20 × Μ′ιι-ΗΟ X lO-iicm'cm / cm ^ sec.mmHg is more preferable, and 20 × M ^ IOOX 10- &quot; cm3.cm/cm, sec * mmHg For the better. The polymer constituting the oxygen-permeable rigid contact lens of the present invention may be appropriately selected from publicly known materials used for oxygen-permeable rigid contact lenses. However, from the viewpoint of requiring a high oxygen permeability coefficient, s contains crushed oxygen. The base monomer unit is fluorene. Examples of such monomers are tris (trimethylsilyloxy) silyldiyl (meth) propionate, heptyltrisilylethyl (methyl) propionate, Pentyl disoxyalkyl (meth) propionate, isobutylhexyl trisiloxane (meth) propionate, methyl bis (trimethylsilyloxy) (methyl) Propionyl via methylsilyl, n-propyloctyltetraoxytetraoxomethyl ester of methylpropionate, pentylbis (trimethylsilyloxyHmethyl) propenylhydroxymethylsilyl, Tertiary butyltetramethyldisoxyalkyl ethyl (meth) acrylate and other (meth) acrylates containing siloxy groups; [tris (trimethylsilyloxy) f silylpropyl ] (Meth) acrylamide, N- (heptyltrisilyloxyethyl) (f-based) acrylamide, N- (pentyldisilaxyl) (meth) acrylamide, ( Isobutylhexyltrisilyl) (meth) propanamine, (n-propyloctylsilylsilylpropyl) (meth) propanil, N · (isobutyltetramethyl) Disoxyxanyl ethyl) (meth) trimethoprim (Meth) acrylic acid 1232972 _ r5 ^ Description of the invention Continuation of amines, etc. Among these, from the viewpoint of durability and pollution resistance to repeated stress, siloxane-containing (meth) acrylic acid Amidoamine is preferred, and N- [tris (trimethylsilyloxy) silylpropyl] (meth) acrylamidonium is more preferred. Monomers containing the above-mentioned silyloxy group may be used in one type. Two or more types may be used in combination. In this specification, [(meth) propionate] means [acrylate] and / or [methacrylate]. The so-called [(meth) propanoate] [Methylmethylsilane] refers to [acryloxymethylsilane] and / or [methylpropoxymethylsilane]. The term "((meth) propylammonamine]" refers to [propylammonamine] ] And / or [methacrylamide]. By adding the above siloxane-containing monomer unit, a polymer having a fluorine atom-containing monomer unit can be used to obtain a high oxygen permeability coefficient and a high oxygen permeability, and Hard contact lenses with excellent pollution resistance and overall balance. Examples of monomers containing fluorine atoms include 2,2,2-trifluoroethyl (meth) acrylate, 2, 2, 2, 2 ', 2', 2'-hexafluoroisopropyl (meth) acrylate, 2, 2, 3, 3, 4, 4, 4-heptafluorobutyl (meth) propionate, 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 8-pentadecafluorooctyl (meth) acrylate, 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9-Hexadecafluorononyl (meth) propionate and other (meth) acrylic fluoroalkyl acrylates, of which one Or more. In order to obtain a polymer containing a desired oxygen permeability coefficient, the weight ratio of the siloxane-containing monomer unit to the fluorine atom-containing monomer unit is preferably within a range of 70: 30 to 30: 70. For the total weight of the polymer, the total amount of the siloxane-containing monomer unit and the fluorine atom-containing monomer unit is preferably 30 to 70% by weight. The polymer constituting the oxygen-permeable rigid contact lens of the present invention has a shape from -10- 1232972 (6) Description of the invention. The stable monomer is preferably an alcohol diester and at least a polymerized monomer. From the tablet, it is better to mention nan as hydroxypropoxy diacid, propyl hydrazone, ammonium acetic acid, etc.) From the viewpoint of the property, it is preferable that the unit contains at least two polymerizable groups in the molecule. It is a monomer having at least two polymerizable groups in the molecule, and examples are alkanol bis (methyl) such as ethylene di (meth) propionate, diethylene glycol bis (meth) propionate, and the like. Propionate, tetramethylolpropane, tris (meth) acrylate isoprene tetraol or tris (meth) propionate, etc. Only one monomer containing two of these polymerizable groups may be used, or two or more kinds may be used in combination. In the case where a monomer unit containing at least two kinds of polymer groups is used, the content of the unit is 0.1 to 20% by weight based on the total weight of the polymer, and the content of the monomer unit is less than 0.1% by weight. In this case, the stability of the obtained lens shape tends to decrease, and if it exceeds 20% by weight, the lens tends to become brittle. The polymer constituting the oxygen-permeable rigid contact lens of the present invention is a polymer containing a hydrophilic monomer unit from the viewpoint of wettability to water.

Is a hydrophilic monomer, such as 2-hydroxyethyl (meth) acrylate, 2-yl (meth) propionate, 2-hydroxybutyl (meth) propionate and other hydrogen-containing ( Methyl) propionate; unsaturated carbonic acid such as malonate, methacrylic acid, methylene butyrate, fumarate, maleic acid, cinnamate, etc; (Meth) acrylamide such as dimethylpropanamine, diethylpropene, etc .; methacrylic acid alkyl esters such as propylene glycol methylpropionate; polyethylene glycol mono (methyl ) Propionate, polypropylene glycol mono (methylene glycol, etc., alkanediol (meth) acrylates; N-vinyl-2-pentanone, N-vinyl-2-salone, N- Vinyl-6-caprolactam, N-11-1232972 Description of the Invention Continued (7)

Vinyl-3-methyl-2-pyrrolidone, N-vinyl-3-methyl-pentylpyridone, N-ethylfluorenyl-3-methyl-6-caprolactam, N-vinyl- 4-methyl-2-pyrrolidone, N-vinyl-4-methyl-2-pentylpyridone, N-vinyl-4-methyl-6-caprolactam, N-vinyl-5- Methyl-2-pyrrolidone, N-ethylfluorenyl-5-methyl-2-pentylpyridone, N-vinyl-5-methyl-6-caprolactam, N-vinyl-6-methyl -6-caprolactam, N-ethylfluorenyl-3-methyl-2-pyrrolidone, N-ethylfluorenyl-4,5-dimethyl-2-pyrrolidone, N-ethylfluorenyl- 5,5-Dimethyl-2-pyrrolidone, N-vinyl- 3,3,5-trimethyl-2-pyrrolidone, N-ethylfluorenyl-5-methyl-5-ethyl- 2-pyrrolidone, N-vinyl- 3,4,5-trimethyl-3-ethyl-2-pyrrolidone, N-ethylfluorenyl-6-methyl-pentanylpyridine I, N- Vinyl-6-ethyl-2-pentylpyridone, N-vinyl-3,5-dimethyl-2-pentylpyridone, N-vinyl-4,4-dimethyl-2- Pentamidine is the same as N-Ethyl-5-ethyl-6-caprolactam, N-ethynyl-3,5-dimethyl-6-caprolactam, N-acetamidine N-ethylene such as methyl-4,6-dimethyl-6-caprolactam, N-ethyl-2,4,6-trimethyl-6-caprolactam, etc. In the first amine. These hydrophilic monomers may be used singly or in combination of two or more kinds. When a hydrophilic monomer unit is contained in the polymer, the content of the monomer unit is preferably 0.1 to 20% by weight based on the total weight of the polymer. When the content of the monomer unit is less than 0.1% by weight, the wettability of the obtained lens tends to decrease. If it exceeds 20% by weight, the obtained lens tends to have high water absorption and lower strength. The polymer constituting the oxygen-permeable rigid contact lens of the present invention is preferably a polymer containing an alkyl (meth) acrylate unit from the viewpoint of improving strength. Examples of alkyl (meth) propanoate include methyl (meth) acrylate, ethyl (meth) acrylate, n-propyl (meth) propionate, and (meth) propan-12-1232972 ( 8) Identifying continuations of inventions

Isopropyl enoate, n-butyl (meth) acrylate, isobutyl (meth) acrylate, tert-butyl (meth) propionate, n-hexyl (meth) propionate, (meth) Cyclohexyl acrylate, (meth) acrylic hard ester, and the like. These alkyl (meth) acrylates may be used singly or in combination of two or more kinds. When the polymer contains alkyl (meth) acrylate units, the content of the alkyl (meth) acrylate units is preferably from 0.1 to 20% by weight based on the total weight of the polymer. When the content of the monomer unit is less than 0.1% by weight, the strength of the obtained lens tends to decrease. If it exceeds 20% by weight, the oxygen permeability of the obtained lens is reduced.

The polymer constituting the oxygen-permeable rigid contact lens of the present invention includes the above-mentioned monomer units and monomer units other than those described above, if necessary, as long as the object of the present invention is not impaired. Examples of such monomer units are fatty acid ethyl acetate from ethyl acetate, vinyl butyrate, vinyl laurate, and the like; dimethyl methylene succinate, diethyl methylene succinate, and the like As the unit derived from the methylene succinate diester, only one type of these monomer units may be used, or two or more types may be used in combination. When these monomer units are contained in the polymer, since the polymer having the above-mentioned superior characteristics and the oxygen-permeable rigid contact lens can be obtained, the content of the monomer unit is about 10% by weight based on the total weight of the polymer. The following is better. In addition, the present invention aims to obtain colored oxygen-permeable rigid contact lenses, so it may contain a pigment. By polymerizing a polymerizable composition containing the above-mentioned monomers in a desired ratio, and forming a contact lens shape, an oxygen-permeable rigid contact lens can be produced. As the polymerization method, a method generally used for polymerizing polymerizable monomers may be adopted. General -13-1232972 Description of the Invention Continued (9) is the addition of a thermally activated polymerization initiator and energy ray (light, etc.) activated polymerization initiation. One or both of the agents are used in the polymerizable composition, and a heat polymerization method or a photopolymerization method is used. Among these, from the viewpoint of obtaining contact lenses that are not optically offset, it is preferable to heat-polymerize the polymerizable composition using a thermally activated polymerization initiator.

When using a thermally-activated polymerization initiator to heat the polymerizable polymerizable composition, it is preferable to use a thermostatic bath, a hot-air circulation type heating device, etc., which is easy to adjust the temperature. Examples of the thermally-activated polymerization initiator include peroxide-based thermally-activated polymerization initiators such as benzamyl peroxide, isopropyl peroxide, 12-fluorene peroxide, and methyl ethyl ketone peroxide; 2,2'-azoisobutyronitrile, 2,2'-azoisobutyric acid methyl ester, 2,2'-azodimethylvaleronitrile, 2,2'-azoisobutyramide, 2 , 2'-Azobutyric acid dimethyl and other nitrogen-based thermally active polymerization initiators. One or more of these thermally activated polymerization initiators can be used.

The amount of the polymerization initiator is not particularly limited, but it is usually about 0.001 to 2 parts by weight based on 100 parts by weight of the polymerizable composition to be polymerized. Corresponding to the manufacture of contact lenses, it is a conventional manufacturing method of contact lenses made of plastic, such as (1) a cutting and grinding method for manufacturing contact lenses, which is a polymerized composition formed by cutting and grinding, and a molded product obtained by cutting and grinding. . (2) a mold method for manufacturing contact lenses, which is a method of filling a polymerizable composition in a mold groove type having a shape equivalent to a contact lens and polymerizing the mold in the mold; (3) a rotary discard method for manufacturing contact lenses, It drips the polymerizable composition around the rotation axis on a high-speed rotation profile, and simultaneously polymerizes the polymerizable composition while diffusing the polymerizable composition radially on the profile surface. (4) -14-12972972 for making contact lenses (10) Blanking method, which is a method of filling a polymerizable composition in a mold groove type having one surface capable of molding contact lenses, and polymerizing and molding in the mold, cutting the other surface and grinding it There are no particular restrictions on its use.

In addition, in the oxygen-permeable rigid contact lens of the present invention, the center thickness of the lens is 0.010-0.125 mm, the diameter of the lens, the diameter of the optical portion of the lens, the thickness of the optical portion other than the center of the optical portion, and the lens on the front side. The dimensions of the radius of the periphery (curvature radius), the radius of the radian side (curvature radius), the radius of the curved side of the slope (curvature radius), and the width of the slope are not particularly limited, and can be appropriately determined. Generally, the diameter of the lens is 8.0-11.0 mm, the diameter of the optical part is 5.0-10.5 mm, and the radius (curvature radius) of the peripheral part of the lens on the front curved side is 6. (Μ〇 · 〇mm, the radius of the radian side (curvature radius) 7.0- 10.0 mm, the radius of curvature (curvature) of the slope is 8.0-12.0 mm, and the width of the slope is 0-2 mm.

Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto. In the following examples, the vickers hardness, oxygen permeability coefficient, oxygen permeability, compressive elastic modulus, compressive tortuous strength, and durability to repeated changing stress of oxygen-permeable rigid contact lenses are measured or evaluated as follows . [Vickers hardness] The Vickers hardness of the oxygen-permeable rigid contact lenses obtained in the following application examples and comparative examples is obtained by a Vickers hardness tester (manufactured by AKASHI). Determination. [Oxygen Permeability Coefficient and Oxygen Permeability] The oxygen permeability coefficient of the copolymers obtained in the following application examples and comparative examples is -15-1232972. The description is continued. (Ii) The scientific research-type film oxygen permeability meter (Science Manufactured by Seiki Industries Co., Ltd.), and measured based on the standard test method of the Contact Lens Association, "Measurement of Oxygen Permeability of Contact Lenses". The oxygen permeability obtained in this manner is the value obtained by dividing the central thickness of the lens as the oxygen permeability. [Compression Elasticity]

For the contact lenses obtained in the following application examples and comparative examples, the compression speed was changed from 200 mm / min to 10 mm / min. Compression twist was performed based on the standard test method of the Contact Lens Association "Compression Torsion Test Method for Contact Lenses". test. The tangent to the deformation start point of the stress-distortion curve obtained when the compression flexure test is performed is the stress at which the stress is extended to the lens diameter as the compression elastic modulus. In addition, "Automatic Chart IM-100" manufactured by Shimadzu Corporation was used for the test. [Compression Torsion Strength]

The oxygen-permeable rigid contact lenses obtained in the following application examples and comparative examples were subjected to a compression tortuosity test based on the Contact Lens Association standard test method "Compression and Torsion Test Method for Contact Lenses". For the test, "Automatic Chart IM-100" manufactured by Shimadzu Corporation was used. [Durability to repeated changes in stress] Contact lenses are generally worn every day, and because of their practical use, they cause scars to enter the lens, and repeated stress is applied. As described above, the present invention has developed a new evaluation method as a durability test considering the use environment. An abrasive having a particle diameter of 20 µm was used to manually rub the oxygen-permeable rigid contact lenses obtained in the following application examples and comparative examples within 15 seconds as a test piece. This test piece is based on JIS KK-71 19 "Flat Bending Fatigue Test Method for Rigid Plastic Flat Plates" and is resistant to repeated stress at a compression speed of 100 mm / min and an amplitude width of 3 mm -16-1232972 Description of the invention continued Page (12) Persistence test, measuring the number of times the respective lenses break. If the stress is not broken even after repeated application of 1,000 times, it is regarded as 1,000 times. The abbreviations of the polymerizable monomers used in the following Examples, Comparative Examples and Tables are shown in Table 1. Table 1 Polymerizable monomer abbreviated compound N-TRIS N- [tris (trimethylsilyloxy) silylpropyl] methacrylamide 0-TRIS tris (trimethylsilyloxy) methyl Silylpropyl] methylpropionate 3FM 2, 2, 2-trifluoroethylmethylpropionate 6FM 2, 2, 2,2 ', 2', 2'-hexafluoroisopropylmethyl Methyl Propionate MMA Methyl Methyl Propionate DMAA N, N-Dimethylpropionamine EGDMA Methyl Glycol Dimethyl Propionate Examples 1-8 and Comparative Examples 1-2

(1) After adding 0.01 g of azoisobutyronitrile as a heat-activated polymerization initiator to 10.0 g of the polymerizable composition shown in Table 2, put it into a test tube (capacity: 20 mL) made of polypropylene and Sealed after replacing with nitrogen. It was immersed in a constant temperature water tank at 55 ° C for 24 hours and allowed to polymerize, and then moved to a hot air circulation heating device at 100 ° C and held for 2 hours to completely polymerize. After cooling, the polymer was removed from the test tube. (2) Using the polymer obtained in the above (1), cut and polish the method to produce the oxygen-permeable rigid contact lenses with diameter, radian, apex refractive power (degrees) and center thickness shown in Table 3, and follow the above Method to measure or evaluate Vic-17-1232972 Description of the Invention Continued (13) Formula (Vickers) hardness, oxygen permeability coefficient, oxygen permeability, compression elasticity, compression flexural strength and durability. The results are shown in Table 4. Comparative Example 3-4: Commercially available oxygen-permeable rigid contact lenses shown in Tables 2 and 3 (Comparative Example 3: Copolymer composed mainly of siloxane-containing methacrylate and methyl methacrylate) Oxygen-permeable rigid contact lens A, comparative example

4: Continuous loading type oxygen-permeable rigid contact lens B composed of a copolymer containing silicon-containing styrene derivative and fluoromethylpropionate as the main component, and the dimension is measured or evaluated according to the above method Vickers hardness, compressive elastic modulus, compression flexural strength and durability. The results are shown in Table 4. The oxygen permeability coefficient is transferred to the value described in the table of contents.

-18- 1232972 (14) Description of the invention Continued Table 2 Proportion of monomer units of polymer (% by weight) N-TRIS 0-TRIS 3FM 6FM MMA DMAA EGDMA Examples 1 40 — 30 10 10 10 Example 2 40 One 30 One 10 10 10 Example 3 40 — 30 One 10 10 10 Example 4 50 — 20 One 10 10 10 Example 5 30-40-10 10 10 Example 6 40-— 30 10 10 10 Example 7 One 40 30-10 10 10 Example 8 — 40-30 10 10 .10 Comparative Example 1 40 _ 30-10 10 10 Comparative Example 2-40 30-10 10 10 Comparative Example 3 Oxygen-permeable rigid contact lens A (containing silicon Oxyalkyl-based polymer of methylpropionate and methylpropionate) Comparative Example 4 Continuous-use type oxygen-permeable rigid contact lens B (a styrene derivative containing silicon and a fluorine group) Polymer with methacrylate as main component)

-19- 1232972 (15) Description of the invention Continued Table 3 Diameter (mm)-Degree (mm) Degree (D) Center thickness (mm) Example 1 8.8 7.75 -3.00 0.080 Example 2 8.8 7.75 -3.00 0.090 Example 3 8.8 7.75-3.00 0.100 Example 4 8.8 7.75-3.00 0.100 Example 5 8.8 7.75-3.00 0.100 Example 6 8.8 7.75-3.00 0.100 Example 7 8.8 7.75-3.00 0.100 Example 8 8.8 7.75-3.00 0.100 Comparative Example 1 8.8 7.75 -3.00 0.150 Comparative Example 2 8.8 7.75 -3.00 0.150 Comparative Example 3 8.8 7.75 -3.00 0.110 Comparative Example 4 9.2 7.75 -3.00 0.130

-20- 1232972 Description of the invention continued (16) Table 4 Vickers hardness Dk * 1 Dk / L * 2 Compression elasticity (gf) Compression flexural strength (gf) Durability (times) Example 1 8.5 53 66 20 200 1000 Example 2 8.5 53 59 24 240 1000 Example 3 8.5 53 53 45 250 1000 Example 4 7.5 66 66 34 230 1000 Example 5 8.9 47 47 47 350 1000 Example 6 8.9 60 60 45 215 1000 Implementation Example 7 9.5 51 51 83 375 800 Example 8 9.9 55 55 85 320 800 Comparative Example 1 8.5 53 35 120 380 400 Comparative Example 2 9.5 51 34 150 250 300 Comparative Example 3 11.7 12 11 40 370 1000 Comparative Example 4 7.4 250 192 120 120 100

(Notes) * 1: Oxygen permeability coefficient, unit: X 10-11cm3 * cm / cm2.sec.mmHg * 2: Oxygen permeability, unit: X 10-9cm3 * cm / cm2 * sec * mmHg * cm From Table 2 The result indicated by -4 is composed of a polymer having an oxygen permeability coefficient of 20 X ΙΟ · llcm3 * cm / cm2 * secTnmHg or more, and the center thickness is within the range of 0.0 10-0.125mm, and the value of the peak refractive power is- The oxygen-permeable rigid contact lenses of Examples 1-8 above 6.00D can withstand repeated stresses of 800 times or more, and their oxygen permeability can be higher than 30X 10-9cm3.cm/cm, sec * mmHg * cm 0 -21-1232972 Description of the Invention Continued (17) For this, Comparative Examples 1 and 2 in which the center thickness of the lens deviates from the scope of the present invention have significantly poor durability. In addition, Comparative Example 3, in which the oxygen permeability coefficient deviates from the scope of the present invention, is significantly smaller than the oxygen permeability 30X 10-9cm3ecm / cm2 * secTnmHg * cm required for all-day wear. In Comparative Example 4 where the center thickness of the lens deviated from the scope of the present invention, the compression flexural strength was low, and the durability was also significantly poor. Industrial availability

By the present invention, an oxygen-permeable rigid contact lens can be provided, which can supply physiologically sufficient oxygen to the cornea, and has superior durability.

Claims (1)

1232972 Brother 091123189 patent application Chinese patent application scope replacement ^ (^ year ^ month) Pick up and apply for patent scope 1. A kind of oxygen-permeable rigid contact lens, the value of its apex refractive power is-6.00E) Bu, ti The oxygen coefficient is 20X l (Tncm3 * cm / cm2 * sec * mmHg or more), and the center thickness is 0.010-0.125 mm. 2. The oxygen-permeable rigid contact lens according to item 1 of the patent application scope, where The hydrate contains a monomer unit containing a siloxy group and a single-cylinder unit containing a fluorine atom. The weight ratio of the monomer unit containing a siloxy group to the monomer unit containing a fluorine atom is 70: 30 ~ 30: Within the range of 70. 3. The oxygen-permeable rigid contact lens according to item 2 of the scope of the patent application, wherein the monomer unit containing the oxoxoxo group is a (meth) propanamine unit containing a zenoxo group. 4. The oxygen-permeable rigid contact lens according to any one of the scope of application patents 丨 to;?, Wherein the Vickers hardness is 5-15, and the compression elasticity is 10-100 gf 〇81120-931105 .doc