TWI227665B - Non-invasive determination of vascular mechanical properties - Google Patents

Abstract

A non-invasive method and simple apparatus for the assessment of the dynamic mechanical properties, such as stiffness, stress-strain hysteresis of the peripheral arteries is demonstrated. Clinical ultrasound B-mode and M-mode imaging are used to record the morphology and motion of peripheral vessel, and the local palpating blood pressure waveform is recorded simultaneously via external input module. Using specific ultrasound probe/pressure sensor holder and semi-automatic image-based edge-detection technique, the stress-strain loading curves of the blood vessel and the intima-media layer can be extracted. The apparatus can also examine the change of peripheral vessel mechanical properties while change the cuff pressure upstream or instantaneous pharmacological treatments. The nonlinear Young s module and the energy dissipation ratio resulted from the parametric analysis are early indicators for atherosclerosis and circulatory vascular diseases.

Description

1227665

V. Description of the invention (1) [Technical field to which the invention belongs] The present invention relates to a human body detection method, combined with vascular ultrasound, with special automated image differentiation, including arterial blood vessel hardness and stool analysis tools to assist the heart Non-invasive one-dimensional imaging of blood vessel arterial blood vessel characteristics and blood pressure pulsation synchronous wave analysis technology, especially for viscoelastic properties of vascular mechanical idiosyncrasy, provide a set of clinical diagnosis of safe side diseases. [Previous technology] Human blood vessels are a complex viscoelastic soft tissue, which plays an important role in the arterial blood circulation system. Changes in the mechanical properties of blood vessels caused by arteriosclerosis, heart blood, and peripheral circulation-related diseases are very important for clinical and diagnostic purposes. important. The mechanical properties of blood vessels, such as compliance, stiffness, etc., can provide g-sciences, and personnel's reference for the prevention and treatment of vascular diseases. Existing methods for detecting the mechanical properties of human blood vessels are often not accurate or invasive, and blood vessels

Viscoeiasticity is often misinterpreted, so S cannot be applied to clinical diagnosis. In Bei, Du Youmo, pulse wave and ruin wave Velocity are often used as indirect indicators of vascular mechanical properties in animals, because the diameter and thickness of blood vessels also change with age and disease. Rules, so the moon wave speed is limited by qualitative analysis. Direct measurement of vascular mechanical quality is often performed by taking out or exposing the measured blood vessels, and measuring the environmental strips makes the vascular stiffness of the child much higher than the actual value. Invasive arterial conduction

.1227665 V. Description of the invention (2) Although the measurement of blood pressure and tube diameter is more accurate, it is difficult for non-critical patients to implement it, so it is very difficult to carry out clinical comparison. ^ In recent years, medical ultrasound imaging diagnostic technology has been continuously improved. With its non-invasive, safe and convenient advantages, it has significant detection in the diagnosis of human tissue lesions, surgical assistance, heart wall motion and blood circulation-related diseases. Practical value. Arndt et al. ["The diameter of intact carotid artery in man and its change with pulse pressure 丨 丨, Pflugers Archiv 301; 230-240, 1968] first applied ultrasound to the study of the characteristics of human blood vessels. Acoustic probe, observing the diameter of the carotid artery (CCA) and the pulsation of the vessel wall, and then using the upper arm (Brachial Artery, BA) blood pressure and pulse pressure difference to estimate the stiffness of the carotid artery (= maximum pulse pressure difference / Tube diameter pulsation). Hokanson and | Mozersky [丨, A phase-locked echo tracking system for recording arterial diameter changes in vivo 丨, Journal of Applied Physiology, 32; 728-733, 1972] locked the signal phase to the blood vessel The phase-locked echo-tracking device can dynamically detect the minute pulsations of human arterial blood vessels. However, due to the unknown positioning of blood vessel scan lines and the simultaneous detection of blood pressure and blood vessel tissue images, there are still shortcomings in practical applications. Stad 1 er et al. [N C 〇mparis ο η of B-mode, and echo-tracking methods for measurement of arterial distension waveform ", Ultrasound in Medicine and Biology, 23; 879-887,

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1227665 V. Description of the invention (3) The _ type adopts the ^ combined Λ super / final mode and the M-mode to obtain the optimized vascular characteristics synchronous analysis mode, which reduces the human recovery from the force in the diastolic tube. It is possible to change the value of the mechanical blood pressure that affects the mechanical state. The value of the blood pressure is non-linear under the action of systolic blood pressure. What is Λmachine? ::: The type change produced by moxibustion does not follow the disappearance of the force of the work. The energy remaining in the tube wall is nhysteresis. The tube is deteriorated ... The fiber composition ratio. —The thickness of the soil varies, due to age or cardiovascular disease 刭 branching of blood vessels, shrinking geometric characteristics, viscoelastic properties, and also the performance of mechanical properties. We can say that the wall of the blood vessel. The f parameter is used to represent it. It is necessary to consider the changes in vascular dynamics. ^ Official experiments have also confirmed that the strain rate of blood vessels changes with ^ ^ so the hardness of human blood vessels will also change with blood pressure around the average blood pressure value. There is a noticeable change in slope. The disease change will also be affected by the age, "pipe disease, interest 1w 'blood anti-transfer function will also change. Therefore, Zhou Luban ^ ^-characteristic analysis must dynamically obtain blood vessels at the same location in synchronization = diameter changes with time. It is a pity that so far in the literature two: two early and non-invasive methods can provide correct blood pressure and vascular dynamics. Tardy et al ["Ν〇η—estimate 〇f VII" p. 9 '1227665 V. Description of the Invention (4) Mechanical properties of peripheral arteries from ultrasonic and photoplethy-smographic measurements ", Clinical Physics and Physiological Measurements, 12; 39-54, 1991] Simultaneously measure the blood pressure wave pattern of the fingertip and the pulsation of the blood vessel diameter of the arm, completely Ignore the viscoelastic properties of peripheral blood vessels to show a non-linear relationship between stress and strain. Β ο η nef 〇us [n Dvice and method for measuring the elasticity of an artery by ultrasonic echography ", US Patent 5411028, 1995] Ultrasonic echo volume measuring device for vascular arteries. Its principle is to obtain vascular diameter pulsations in the echoed M-mode. Synchronized ultrasound Doppler's blood flow signal uses the mathematical parameters of the windkesse 1 theoretical model to estimate blood pressure pulsations from the blood flow pattern. Because the physical parameters between blood pressure and blood flow are subject to many individual, physiological differences, and disease Influence, so it is not accurate enough for clinical application. Only the actual measurement synchronization, co-location vascular pulsation and blood pressure pulsation can really solve this problem. We use dynamic elastic coefficient combined with vascular viscoelastic energy loss to show the degree of vascular disease or vascular material. Changes. Viscoelastic properties of blood vessels are obviously an important indicator of blood circulation deterioration. Therefore, we developed an ultrasonic measurement system for the measurement of blood pressure and blood vessel diameter. With image processing technology, the diameter of the blood vessels at the same time can be obtained. And blood pressure data to establish dynamic characteristics of blood pressure, vascular diameter, and wall tissue strain. The preliminary technical paper of the present invention was published in " Non-invasive Assessment of the

Viscoelasticity of Peripheral Arteries, Ultrasound

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in Medicine and Biology, 2 5 (9): 1 377- 1 388 (1 999) 11 ^ The initial study of clinical relevance can be found in "Shao Yaohua, Non-invasive Arterial Viscoelasticity Testing, National Taiwan University Engineering Journal 79, New Knowledge of Science and Technology, PP. 1-10 (200 0). In the published papers, although some techniques of $ correction and image analysis have been revealed, the key techniques for the selection of automatic grayscale processing of the vascular wall and the selection of threshold levels for the grayscale of each layer of the vascular wall have not been published. Therefore, the application of international scholarship still cannot keep up with the progress of this research team. In this creation, we have modified the implementation methods and procedures to improve the accuracy and system stability of clinical applications, and provide automated detection technology. Non-invasive diagnostic technology is easy to get the cooperation of patients, and can be quickly combined with clinical technology and applied to the diagnosis of circulating diseases such as diabetes and hypertension. [Summary of the Invention] The purpose of this creation is to provide a simple and accurate method for synchronously recording blood pressure and pulsation of blood vessels. Through special image processing technology, the vascular mechanical dynamic characteristics, compliance, and arterial strain , Young's coefficient (Young's m0duius) and energy dissipation ratio (EDr), etc. for non-invasive detection. In addition, this method can also provide the dynamic mechanical properties of arterial vascular inner layer tissue (jntima-media layers), providing an important reference for the initial arterial vascular sclerosis. [Embodiment]

Page 1227665 Five invention descriptions (6) Steps The purpose of this creation, the hardware and software analysis required to provide a door, a partition Λ cool tool ^ ultrasonic probe and a pulse pressure gauge combination, suitable for :: If you use the appropriate elastic band of the factory to fix the two green body i meter and the ultrasonic sensor probe, placing it on the test 2Ϊ4ΓΓ will affect the blood pressure signal 1 method to record the period =: Therefore the stability of the fixture is very ", and Fixture: Then gently press ^ to scratch the subject's fragile skin. The pulse pressure manometer 2 catches the Λ body. The pulse pressure manometer signal is processed with a suitable amplifier circuit, input and other auxiliary physiological signals. Channel tube = image; "ί has recorded β-mode vascular shadows of several heartbeat cycles (such as εκΛ / Λ Μ—mode display; turn on the external signal bluff) display the signal voltage on the image screen; display the resulting signal containing ϊ;: = ^ mode ... output the record to the corresponding step display Λ blood: `` ^: the better the better '' But you should avoid the signal being too high and full.

The image analysis method was used to capture the vascular pulsation waveform and blood pressure waveform; The scale adjusts the blood f-tube diameter value and the pulsation according to the tb case rule to limit the length. Qian Tubular wall pulsation U wall reflection efficiency or intensity will not be affected by blood vessel movement or individual

V. Description of the invention (7) 3:: Γ 二 ☆ In the gray-scale image of the ultrasonic from-mode, ★ from the air to the large part, after the image is straight, (1) the nose gray gradient is the most ⑺ Build Vascular Tube: Values are suggested for automated grayscale values. Plot), E.M. Earth ash value 4-bit line atlas (Contour type, analysis and analysis of A and B automatically select the wave most similar to the blood pressure wave shape ^ this official wall pulse wave interface gray level threshold value 钤+ ^ v / Α when it refers to the moving wave pattern of 棹. The maximum gradient in the literature is good, and it needs artificial: Γ: =;: The effect is affected by the resolution of the image. It does not affect the condition of vascular sclerosis or ^ wave processing. To the elderly or the diabetic threshold threshold is about 捸 ^ ΐ b. The best gray wall threshold value pair f ::: i within 2 ° of the best pipe wall interface used in the creation of this book, so find the automatic maximum value interpolation. Tube ΐ._Best gray-scale valve Lu Tu M town pulsation, you can find the wave shape of the ripping pulsation. 0 is the vascular pulsation :: the two between; the number of operations to determine the speed is generally high (1. "】 The other time of the second wave "The wave shape of the pressure wave can also be obtained by using the edge detection method of the image. For the value of A pressure, the value of f and pressure must be corrected. Human MJ sighs A 时 卜卜 妙妙 # ^ This blood pressure wave pattern and vascular diameter pulse wave pattern still exist in a fixed systemic range between π The amount of deviation between t. Using the M-mode ultrasonic image to analyze the image, especially the thickness of the middle layer tissue in the needle tube (: [111; 1 with 1 to: ^ 1: 1141 ^ 6 ^, 1 ^) Try to respond to the time-domain wave pattern of the change in gold pressure. The tissue of the intima (media) to the media (media) is similar to the blood pressure in the blood pressure, while the tissue of the advantitia is because of the muscle 1227665 V. Description of the invention (8) The role of the flesh layer increases the viscoelastic properties. Therefore, the correlative analysis of the wave pattern and the change in the gray gradient can be used to more accurately identify the interface of the inner and middle tissues and define its thickness. 5. Measure the contraction of the peripheral blood vessels Pressure and infusion pressure; measure blood pressure with a general barometric blood pressure measurement, and correct the blood pressure waveform of the previous paragraph to the corresponding C uff blood pressure value. In the carotid artery, because the blood pressure is blocked by a general sphygmomanometer, it can be dangerous by the arm The arterial and radial arterial blood pressure values are linearly calculated according to the distance from the heart. 6. Simultaneously obtain the peripheral blood pressure and tube diameter pulsation waveform data (stress-strain) analysis; (a) Calculate tube diameter strain, blood pressure and tube diameter strain Load curve, (b) Calculate dynamic vascular Young's coefficient and energy dissipation rate (EDR) with load curve, and provide parameters of blood vessel material for diagnosis. 7. Simultaneously obtain blood pressure and peripheral wall thickness (IMT) change wave of peripheral blood vessels. Type data (stress-strain) analysis; (a) Calculate load curve of blood pressure and tube wall I MT tissue strain, (b) Calculate Young's coefficient and energy dissipation rate (IMT-EDR) of dynamic blood vessel MT tissue by load curve ).

Page 14 1227665 Schematic description [Simplified description of the diagram] Schematic description: Figure 1 shows the combined schematic diagram of the creative measurement system. Figure 2 shows the synchronous analysis of the B-mode, M-mode, and blood pressure wave images of the author. Figure 3 shows the flow chart of image acquisition and analysis. Figure 4 (a) Synchronized blood pressure and pulsation pattern of blood vessels. (B) Load diagram of blood vessels receiving blood pressure pulses. Figure 5 shows (a) blood vessel wall B- Mode, M-mode graphics, the thickness of the inner layer of blood vessels is measured with images, and IMT (b) is a time-varying graph of blood vessel IMT with blood pressure pulsation [illustration of symbol code] 2 ........... Ultrasonic image scanning system 4 ..................................................................................................... Terminal 6 ........... Ultrasonic probe 8 ........ ............ Pulse pressure manometer 10 ....... ............... Acrylic Fixture 14 ............. .......... elastic band

Page 15 1227665 Illustration of the diagram 18 ... 2 2 2 2 4 2 3 8 2 3 4 3 3 6 4 3 6 4 6 · ..

'····· Screws for fixing the pressure gauge • * · · · Ultrasonic gel coupler • Pulse pressure gauge signal amplification circuit · · · Pulse image of blood vessel M-mode ... ..Pulse pressure image • ··· .......... Computer platform ····· ..... Image capture device ··: ... Image ^ tube image edge detection technology flow [detailed description of the meal] Ji Ji = using the ultrasound system combined with palpation pressure gauge to provide-a common method = recording blood pressure and vascular pulse, through special image processing, aggressively Establish the vascular diameter and the inner middle layer tissue (I ^ ^ VII — _ 11 Π should respond to the blood pressure pulse hyperbolic curve. Local peripheral vascular mechanical dynamic characteristics, Young s modulus) and energy dissipation rate (plus dozen Ti, and other parameters provide an important reference for the early diagnosis of arterial vascular sclerosis. It is very invasive, which is helpful for vascular aging, and is a useful tool for diagnosis of vascular disease. &Amp; Petrochemical, diabetes The non-aggressive schematic diagram according to the embodiment of the present invention and hypertension is shown in Figure 1. _ 如 θ乂 g stacking machine characteristic detection system narrative / ready B-mode two-dimensional image and I-mode 1227665

The input pressure of the dynamic shadow is placed on the human potential, separated by appropriate fixing clips (when there is a gap of 1 degree, the ultrasonic image of a large number of inverse images is scanned with 4 display functions 3n), and it is used with an external voltage signal type detection element to Acrylic clamp 1 〇 fixed = arteries i 2. The person usually lays flat on the mouth 2. Di Qing's "fixed to the limbs of peripheral arteries with υπsonic probe 6 and pulse pressure manometer 8 to 4 force I force meter 8 You can adjust the depth and use 2 screws

There is a strong difference in acoustic impedance between the contact surface of the ultrasonic probe 6 and the skin, which makes the ultrasonic U; the impedance is added with gel 2 2 as a coupling agent, and the pulse pressure gauge 8 signal needs to be appropriately Amplifying circuit 2 The external signal channel 4 (such as EKG, A-LINE, and other auxiliary physiological qi, every channel) enters the skin imaging system 2. In the two-dimensional ultrasound of ultrasound :: Frequency scan through the scanning line 2 of the blood diameter 6. Pulse of vascular M-mode 2 4

Pulse pressure bluff 3 0 can be displayed on the screen 3 2 at the same time. The obtained blood vessel scan image data with 8 disease-beating cycles was recorded in the ultrasound capture image by the image capture device 36, the heart and brain m, and the ultrasound tissue image was recorded simultaneously: tube to imitation position, e B! Pulse 2 8 and Corresponding blood pressure wave pattern 30. The traditional method of synchronizing the echo output of a single ultrasonic wave and the pressure gauge signal to synchronize the processing of array-type ultrasonic scan data is quite difficult. ^, '° put

Page 17 1227665 Brief description of the diagram The magnification of the large circuit 2 4 should make the blood pressure waveform 3 0 on the screen 3 2 the more obvious the better. However, avoid excessive signal saturation and damage to the ultrasound electronic hardware.

Figure 2 reveals the blood vessel B-mode 3 8 and the M-mode pulsation waveform image 4 〇 and synchronized blood pressure waveform 4 2 processed on the computer platform 34. The data processing module must first set the image scan The scale bar represented by the depth scale 4 4 is used to mark the position of the blood vessel and the diameter of the blood vessel in the B-mode ultrasound image by the mouse pointer. The digitization of the blood pressure wave pattern 4 2 can be processed by curve edge debt measurement with a general fixed threshold value, and will not be affected by human factors. The maximum (systolic blood pressure) and minimum (diastolic blood pressure) values of blood pressure need to be taken from the known blood, and the metering (〇scillometric sphygm manometer) is taken in the name blood. The carotid blood pressure value is dangerous because the blood flow is blocked by a general sphygmomanometer. We can calculate the blood pressure value of the arm arteries and radial arteries according to the distance from the heart in a linear proportion. To capture the pulsation pattern of the vessel wall from the ultrasonic gray-scale image in a mode, first select the image of the vessel wall area (R0I) 4 5 by the mouse pointer, and then measure the edge of the vessel image. Techniques 4 and 6 are analyzed.

Since the coordinate axis of the ultrasonic M-image mode is time, the position with the largest gradient (the position with the largest change in acoustic impedance) in this region will be the tube wall. If the tube wall is taken at the position with the largest known gradient: motion: mourning: displacement : The resolution cannot meet the functional requirements. Figure 3 shows the workflow of the edge detection technology of this creative image

1227665 Simple illustration of the diagram 5 0 can be added with the required image filtering 5 2, first digitize the blood pressure waveform 4 2 5 4 'set the image scale 5 6, select the wall area of the blood vessel as R〇I (Region Of Interest ) 5 8, find the shadow in the pipe diameter area

The position of the maximum gradient like gray scale is 60. In this creation, the gray level value corresponding to the maximum gradient is an automated recommended threshold value. If 2 56 gray level value (8-bit) is taken as an example, the optimal gray level threshold value is approximately within the recommended gray level value ± 2 〇 Inside. Using the best gray-level threshold value to search for the time-varying curve of vascular wall pulsation along the time axis using the linear internal difference edge detection method 62, a representative wall displacement waveform can be automatically found. The pulsation wave shape of the tube diameter can be obtained by the pulsation position difference amount of the upper and lower tube walls of the blood vessel, and the pulsation value is corrected by the change of the tube diameter of the two-dimensional image of the blood vessel. On the other hand, the wave pattern correlation analysis of the gray-scale isoline of the pipe wall is used to separate the interface of the inner and middle tissues and define the pulsating wave pattern of the interface affected by blood pressure. ; | In some parts of the blood vessel is compressed by the surrounding tissue to form an oval factory ultrasonic sense blood vessel. The scan line of the diameter of the obscured blood vessel needs to be measured by the mold. Once measured, the long axis (A) and the short axis (B) of the circle ), Calculate the equivalent tube £: ED tSQRT (AB). Affected by the cross-section of the oval blood vessel, if the condition is obtained: the obtained tube diameter value is smaller than the equivalent tube diameter, and the tube repair pulsation amount = the value paid is small, and it should be reduced in relative proportions. Due to the fact that the ultrasound image is displayed the same, the blood pressure wave pattern and blood have a fixed, unified time. The external signal and the time required by the tissue and shadow orphan are still different in time regardless of the diameter of the pulse wave pattern. Perform synchronization correction ^ 4.

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2 乂 The amount of difference between the seasonal orders needs to be corrected with high-frequency pulsating prosthesis, which is usually about 0.02 seconds. The blood pressure load stress-strain relationship pulsated by the diameter of the blood vessel can be different from the mechanical characteristics of the soft tissue of the blood vessel 5 6 (including the dynamic golden tube diagram to briefly explain 1 shot energy dissipation rate f. M is the blood pressure of the blood vessel IMT tube wall thickness, load The stress-strain relationship can be calculated by the IMT soft group binding machine 5 8 (including dynamic vascular Young's coefficient, viscoelastic energy, dissipation rate, etc.). = (A) shows the blood pressure wave pattern obtained in the arteries of young people. The pulsation wave pattern is 8 〇. The two are very similar. The blood pressure value and the pulsation of the blood vessel diameter are plotted as a figure (Figure 4 (b)). The slope of the pulsation ratio (strain) curve is 丄, i and Π. 2 With the blood pressure ㈣; sophomore changes the money to show the dynamic Young's coefficient of the golden tube :: The falling load path "doesn't the area surrounded by V 8? •: Quality: the energy of 1 dynamic behavior 'long-term effect is to cause blood, The reason for the second line of the package. / Jin The dimension under the load curve of the load curve 'Zen energy, HF divided by the blood pressure rise load curve is defined as sticky gy DissipatiGnRati in a dimensionless ratio; Jue), Jiang Gang blood! Tube Wall loss energy ... than,-once accumulated in the article; :::, will The change in the material of the f is like a rubber strip. When the εμ is larger, the Λ amount Λ is easy to harden, bounce, or even break. Because people are below 5%, the wall of Dingxuanguan will accumulate more More energy. Generally normal 1227665

The diagram simply illustrates that on the other hand, because the artery is a strong elastic blood vessel, its wall can be divided into three layers, the innermost layer is the intima (intima), and a single layer of the squamous epidermis (endothelium 'end 〇the 1 ium), attached to an elastic connective tissue membrane containing elastic fibers and collagen fibers. The middle layer is the middle membrane (me d i a), which is composed of smooth muscle fibers and elastic and connective tissue around the blood vessels. The outermost layer is adventitia, which consists of irregularly arranged elastic fibers and collagen fiber connective tissue. With increasing age, the component effects of the vascular wall tissue also change. Generally speaking, the collagen fibers in the blood vessels increase and the elastic fibers decrease in the older age. The elasticity of the blood vessels decreases and the material becomes harder. When some chronic diseases occur, these processes will be gradually arrested to make the blood vessels Deterioration, causing problems such as tube wall sclerosis, increased blood pressure, and poor terminal circulation. Due to the ultra-wave image (Figure 5 (a)), it can be seen that the echo of the g fluid in the blood vessels is very small and black, in the middle and middle layers of the gray tube and the outer layer (advantitia) of the 2 2 (intima- boundary). The mode image can also capture the time-varying wave of the thickness of the middle layer of the blood vessel with a 4: = 2 gradient analysis method. The time-varying wave pattern is 96 (Figure 5). As shown in Figure r and the synchronous blood pressure, the IMT strain of the tube wall is used. The blood pressure load curve can be the same as that of b = b) to establish the Young's coefficient and the viscoelasticity of the vascular IMT tissue ^ = the dynamic EDR of the blood officer 1MT). Flat moon dagger, shoulder loose rate (IMT-

Claims (1)

^ / 665 Α Patent application scope ~ Kind of non-jin ^ Including the following steps Detection method of culturally invasive visco-elastic properties of blood vessels ◎ Provide ~ + less packet interval p [* Loss of equipment will be ultrasonic probe and-pressure gauge electrician, ◎ Λνν: an appropriate elastic band fixed to the vascular mouth of the human & fixed type; the systolic pressure and infusion pressure of the blood vessel at the 以 position should be _ body surface; ◎ touch the% θ, nocturnal wave system, and the dynamometer signal to the appropriate Enlarged circuit processing, two-dimensional image of the f tube connected to the relative library, pulsation of the diameter of the blood vessel (M is connected to the ◎ and the tomb pressure wave pattern is displayed on the screen simultaneously; such as heart) The computer platform contains several heartbeat cycles of blood vessel changes The image recording transfer wheel ◎ Use the method "Did you, the middle-level button / knife analysis to capture the synchronized vascular pulse wave pattern, tube # ◎ and ^ thickness deformation amount and blood pressure wave pattern; B wall I :, scale of scanning depth Set the image scale scale; adjust the vascular equivalent tube diameter value and equivalent pulsation value; ticks an automatic image processing, will synchronize the blood pressure fish and cross-shaped lean material obtained at the same location, calculate the vascular tube diameter and the tube wall Middle-level organization media thickness; IMT) should the force - strain curve, the Young's modulus and eight a dynamic convergence rate of energy dissipation (: edr). Knife analysis 2 · As described in the first patent application scope of the non-invasive vascular mechanical viscoelasticity detection method, the clamp (ultrasonic probe and pressure gauge) is fixed to the blood vessel of the subject with an elastic end band. Page 22, 1227665 VI. Scope of patent application — 3 · As described in the first patent application scope of the non-invasive vascular mechanical viscoelastic characteristics detection method, automatic image processing to synchronize blood vessel diameter pulsation with palpation blood pressure changes analysis. 4 · The non-invasive detection method of mechanical viscoelasticity of vascular machinery as described in item 3 of the scope of patent application, automatic blood vessel edge image search, adopting the best gray level threshold corresponding to the maximum gray level to fix the gray level Threshold image interpolation method tracks the movement of blood vessel wall edges over time, and provides an automatic pipe diameter pulsation wave pattern with a grayscale isomap. 5. The method for detecting non-invasive vascular mechanical viscoelastic properties as described in item 1 of the scope of patent application, mechanical property parameters derived from the stress-strain relationship (load curve) of the vascular wall, such as hardness, dynamic Young's The coefficient and energy dissipation rate (EDR), and the changes of each value along the layers of the pipe wall. 6 · The method for detecting non-invasive vascular mechanical viscoelastic properties as described in item 1 of the scope of the patent application. Mechanical property parameters derived from the stress-strain relationship (load curve) of the inner layer tissue (IMT) in the tube wall, such as Intima-media stiffness, dynamic Young's coefficient, and energy dissipation rate (intima-med ia EDR), etc. 0 Page 23