TWI224504B - Pharmaceutical compositions comprising bisphosphonate for the treatment of angiogenesis - Google Patents
Pharmaceutical compositions comprising bisphosphonate for the treatment of angiogenesis Download PDFInfo
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- TWI224504B TWI224504B TW089109918A TW89109918A TWI224504B TW I224504 B TWI224504 B TW I224504B TW 089109918 A TW089109918 A TW 089109918A TW 89109918 A TW89109918 A TW 89109918A TW I224504 B TWI224504 B TW I224504B
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- Prior art keywords
- acid
- angiogenesis
- bisphosphonate
- patent application
- pharmaceutical composition
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9911926.5A GB9911926D0 (en) | 1999-05-21 | 1999-05-21 | Organic compounds |
| GBGB9925131.6A GB9925131D0 (en) | 1999-10-22 | 1999-10-22 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI224504B true TWI224504B (en) | 2004-12-01 |
Family
ID=26315578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW089109918A TWI224504B (en) | 1999-05-21 | 2000-05-23 | Pharmaceutical compositions comprising bisphosphonate for the treatment of angiogenesis |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20020142996A1 (enExample) |
| EP (1) | EP1178810B8 (enExample) |
| JP (1) | JP2003500352A (enExample) |
| KR (1) | KR100763064B1 (enExample) |
| CN (1) | CN1202828C (enExample) |
| AT (1) | ATE293450T1 (enExample) |
| AU (1) | AU775079B2 (enExample) |
| BR (1) | BR0010808A (enExample) |
| CA (1) | CA2374049A1 (enExample) |
| DE (1) | DE60019580T2 (enExample) |
| DK (1) | DK1178810T3 (enExample) |
| ES (1) | ES2240106T3 (enExample) |
| HU (1) | HUP0201329A3 (enExample) |
| IL (2) | IL146520A0 (enExample) |
| NO (1) | NO322212B1 (enExample) |
| NZ (1) | NZ515541A (enExample) |
| PL (1) | PL351674A1 (enExample) |
| PT (1) | PT1178810E (enExample) |
| SK (1) | SK16682001A3 (enExample) |
| TW (1) | TWI224504B (enExample) |
| WO (1) | WO2000071104A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287278B6 (sk) * | 2000-06-20 | 2010-05-07 | Novartis Ag | Použitie kyseliny 1-hydroxy-2-(imidazol-1-yl)etán-1,1- difosfónovej na prípravu liečiva na liečenie stavov abnormálne zvýšeného kostného obratu |
| SI1591122T1 (sl) * | 2000-06-20 | 2013-02-28 | Novartis Ag | Postopek za aplikacijo bisfosfonatov |
| CN1233325C (zh) * | 2001-02-06 | 2005-12-28 | 罗亚尔·亚历山德拉儿童医院 | 治疗骨坏死和处理有发展为骨坏死危险的患者用的药物 |
| RU2297229C2 (ru) * | 2001-05-02 | 2007-04-20 | Новартис Аг | Фармацевтическое применение бисфосфонатов |
| ES2336312T3 (es) * | 2001-07-16 | 2010-04-12 | Universite Paris 13 | Procedimiento de preparacion de derivados de bisfosfonatos. |
| TWI315982B (en) | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| CA2478317A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin .alpha.v.beta.3 antagonist in combination with an hmg-coa reductase inhibitor or a bisphosphonate |
| CA2763775C (en) | 2002-05-10 | 2014-01-07 | F. Hoffmann-La Roche Ag | Bisphosphonic acids for the treatment and prevention of osteoporosis |
| DE60233576D1 (de) * | 2002-12-02 | 2009-10-15 | Innate Pharma | Interleukin-2 und Gamma Delta T Zellaktivator enthaltende Zusammensetzungen und deren Verwendungen |
| WO2005014006A1 (en) * | 2003-07-21 | 2005-02-17 | Novartis Ag | Combinations of a cathepsin k inhibitor and a bisphophonate in the treatment of bone metastasis, tumor growth and tumor-induced bone loss |
| EP1723157B2 (en) † | 2004-02-26 | 2017-02-08 | Zentiva, k.s. | Amorphous forms of risedronate monosodium |
| KR20070043043A (ko) * | 2004-08-23 | 2007-04-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 고체 및 결정 이반드로네이트 나트륨 및 이들의 제조 방법 |
| US7914810B2 (en) | 2005-05-06 | 2011-03-29 | Synthes Usa, Llc | Methods for the in situ treatment of bone cancer |
| PE20070360A1 (es) * | 2005-09-01 | 2007-04-19 | Novartis Ag | Composiciones de liposomas |
| US20070218116A1 (en) * | 2006-03-14 | 2007-09-20 | Schwendener Reto A | Compositions and methods for the treatment of tumors and tumor metastases |
| EP2255199A1 (en) * | 2008-02-19 | 2010-12-01 | Jovesis Inc. | Microparticle compositions to modify cancer promoting cells |
| KR101813728B1 (ko) | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| WO2015018659A1 (en) * | 2013-08-05 | 2015-02-12 | Vib Vzw | Glutamine synthetase inhibitors for inhibition of pathological angiogenesis |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067971A (en) * | 1976-05-13 | 1978-01-10 | The Procter & Gamble Company | Therapeutic composition |
| DE3425812A1 (de) * | 1984-07-13 | 1986-01-16 | Deutsches Krebsforschungszentrum, 6900 Heidelberg | Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren |
| IT1187828B (it) * | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| GB8618259D0 (en) * | 1986-07-25 | 1986-09-03 | Leo Pharm Prod Ltd | Pharmaceutical compositions |
| US5116864A (en) * | 1991-04-09 | 1992-05-26 | Indiana University Foundation | Method for preventing restenosis following reconfiguration of body vessels |
| US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
| TW390813B (en) * | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
| SE9402001D0 (sv) * | 1994-06-09 | 1994-06-09 | Leiras Oy | Pyridylbisphosphonates for use as a therapeutical agent |
| IT1290444B1 (it) * | 1997-03-27 | 1998-12-03 | Boehringer Mannheim Italia | Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale |
| ES2269014T3 (es) * | 1997-07-22 | 2007-05-01 | MERCK & CO. INC. | Procedimiento para inhibir la resorcion osea. |
| US5994329A (en) * | 1997-07-22 | 1999-11-30 | Merck & Co., Inc. | Method for inhibiting bone resorption |
| US6048861A (en) * | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| WO1999033473A1 (fr) * | 1997-12-25 | 1999-07-08 | Toray Industries, Inc. | Remedes contre les maladies intramedullaires |
| WO1999038998A1 (en) * | 1998-01-29 | 1999-08-05 | Merck & Co., Inc. | Methods of identifying modulators of kinases responsive to stress |
| US6416964B2 (en) * | 1998-01-29 | 2002-07-09 | Merck & Co., Inc. | Methods of identifying modulators of kinases responsive to stress |
| IL125336A0 (en) * | 1998-07-14 | 1999-03-12 | Yissum Res Dev Co | Compositions for inhibition and treatment of restinosis |
| US6416737B1 (en) * | 1998-11-19 | 2002-07-09 | Board Of Trustees Of The University Of Arkansas | Increasing bone strength with selected bisphosphonates |
| US6426367B1 (en) * | 1999-09-09 | 2002-07-30 | Efa Sciences Llc | Methods for selectively occluding blood supplies to neoplasias |
| US6677320B2 (en) * | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
-
2000
- 2000-05-19 SK SK1668-2001A patent/SK16682001A3/sk unknown
- 2000-05-19 PT PT00936760T patent/PT1178810E/pt unknown
- 2000-05-19 ES ES00936760T patent/ES2240106T3/es not_active Expired - Lifetime
- 2000-05-19 BR BR0010808-1A patent/BR0010808A/pt not_active Application Discontinuation
- 2000-05-19 EP EP00936760A patent/EP1178810B8/en not_active Revoked
- 2000-05-19 JP JP2000619411A patent/JP2003500352A/ja active Pending
- 2000-05-19 WO PCT/EP2000/004562 patent/WO2000071104A2/en not_active Ceased
- 2000-05-19 AU AU52141/00A patent/AU775079B2/en not_active Ceased
- 2000-05-19 DK DK00936760T patent/DK1178810T3/da active
- 2000-05-19 AT AT00936760T patent/ATE293450T1/de not_active IP Right Cessation
- 2000-05-19 PL PL00351674A patent/PL351674A1/xx not_active Application Discontinuation
- 2000-05-19 DE DE60019580T patent/DE60019580T2/de not_active Revoked
- 2000-05-19 IL IL14652000A patent/IL146520A0/xx active IP Right Grant
- 2000-05-19 NZ NZ515541A patent/NZ515541A/xx unknown
- 2000-05-19 KR KR1020017014807A patent/KR100763064B1/ko not_active Expired - Fee Related
- 2000-05-19 HU HU0201329A patent/HUP0201329A3/hu unknown
- 2000-05-19 CA CA002374049A patent/CA2374049A1/en not_active Abandoned
- 2000-05-19 CN CNB008092117A patent/CN1202828C/zh not_active Expired - Fee Related
- 2000-05-23 TW TW089109918A patent/TWI224504B/zh not_active IP Right Cessation
-
2001
- 2001-11-15 IL IL146520A patent/IL146520A/en not_active IP Right Cessation
- 2001-11-19 NO NO20015638A patent/NO322212B1/no unknown
- 2001-11-20 US US09/989,577 patent/US20020142996A1/en not_active Abandoned
-
2004
- 2004-03-24 US US10/807,736 patent/US20040176327A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040176327A1 (en) | 2004-09-09 |
| CA2374049A1 (en) | 2000-11-30 |
| DE60019580D1 (de) | 2005-05-25 |
| WO2000071104A2 (en) | 2000-11-30 |
| EP1178810B1 (en) | 2005-04-20 |
| IL146520A0 (en) | 2002-07-25 |
| CN1384749A (zh) | 2002-12-11 |
| AU5214100A (en) | 2000-12-12 |
| EP1178810A2 (en) | 2002-02-13 |
| NZ515541A (en) | 2003-03-28 |
| HUP0201329A2 (en) | 2002-08-28 |
| DE60019580T2 (de) | 2006-03-09 |
| IL146520A (en) | 2006-09-05 |
| KR100763064B1 (ko) | 2007-10-04 |
| NO20015638D0 (no) | 2001-11-19 |
| ES2240106T3 (es) | 2005-10-16 |
| US20020142996A1 (en) | 2002-10-03 |
| BR0010808A (pt) | 2002-08-27 |
| DK1178810T3 (da) | 2005-07-11 |
| JP2003500352A (ja) | 2003-01-07 |
| WO2000071104A3 (en) | 2001-07-19 |
| HUP0201329A3 (en) | 2005-02-28 |
| EP1178810B8 (en) | 2005-07-27 |
| PT1178810E (pt) | 2005-08-31 |
| AU775079B2 (en) | 2004-07-15 |
| NO20015638L (no) | 2002-01-15 |
| ATE293450T1 (de) | 2005-05-15 |
| CN1202828C (zh) | 2005-05-25 |
| SK16682001A3 (sk) | 2002-04-04 |
| PL351674A1 (en) | 2003-05-19 |
| KR20010113830A (ko) | 2001-12-28 |
| NO322212B1 (no) | 2006-08-28 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |