TW557284B - Multi-directional logic micro fluid control system and method - Google Patents

Abstract

Disclosed is a multi-directional logic micro fluid control system and method, which determines the directions and numbers of fluid flows to be mixed by controlling whether or not fluids in micro-channels connected to a micro fluid member flows through the channels. That is, in a plurality of micro-channels that is connected to the fluid member, fluids are allowed to flow through the micro-channels that are in the direction along which the fluid is to flow, while fluids are prevented from flowing through the micro-channels that are not in the direction along which the fluid is to flow. A system accommodating the above method to controller loaded with a program allows more complicated fluid movement.

Description

557284 V. Description of the invention (1) [Technical field to which the invention belongs The present invention relates to a fluid control system and a method thereof, and more particularly to a multi-directional logic microfluidic control system and a method thereof [prior art] vWith wide application The development of a micro-total analysis system (M i cr0τ〇 七 ai A⑽ 卜 sis Systejns', # _TAS) for combinatorial chemistry, genomic and proteomic techniques, and other analytical instruments and systems A new era of advancement, even on the order of nanometers. The micro-total analysis system integrates experimental chemical or general chemical reactions on tiny wafers. For example, one end of a large substance fragment is fixed on the surface of the wafer, and the interaction between the shellfish fragment and various specimens is similarly performed. R fishing: The test requires some fluid processing steps to make the micro-total analysis system: enough for the rabbit to play its role, so that the substance in the wafer reacts with the specimen entering the wafer. And in the absence of liquid handling devices or similar mixed flows :: 詈 了: ί ί Γί and flow automation. Therefore, some microfluidic actuators were born to solve the problem of fluid processing. Most of the microfluidic drive devices are unidirectional or bidirectional, and 3 kg are used. Mechanical micropumps and non-mechanical type 1 micro pumps are noniechanic micropups. Lack of intelligent tritium fluid control. When used for more complicated biochemical reactions and detection analysis, it is often difficult to control the mixing and reaction steps of the required fluids. '^ Take,-Therefore, in today's technology needs for micro-total analysis system testing, chips that can perform complex and automated testing have become one of the important development directions. In cases where the pump technology cannot meet such requirements, it is necessary to design other simplified

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Easy fluid control method responds. SUMMARY OF THE INVENTION In view of the problems of the above conventional technologies, a microfluidic control system and a method thereof are directed to the purpose of mixing. 'The present invention provides a multi-directional logic to achieve effective control of the microfluidic flow side' 本 上 ί 目 ㈤ 'The present invention includes a multi-directional logical microfluidic control = ,: two or two earth materials and a plurality of microfluidic control points, Among them, the fluid is really in the micro-manufacturing of the substrate. The invention is more special is a substrate (,,, ubs tr = te) sigh meter, which has a microfluidic element and a plurality of microtubules 逞 1 micro-guan This system and the microfluidic element form the same plane and are connected to it For physical components, a microfluidic control point is installed corresponding to each micro-channel system, which is used to control whether the micro-channel fluid passes or not. Permeate and drive several passes, non-directional fluids can be connected to flow through the pipeline, through this kind of moving substrate micro-channel fluid pre-scheduled flow for four levels of fluid. Among the three micropipes designed earlier and earlier, the micro cross array special micropipes in the plane direction of the fluid flowing in the direction of movement and the direction of flow can make the fluid flow in the direction of the microfluid in the present invention. The fluidity of pipeline 0, such as 5 cross-type pipelines, allows the remaining microfluids to be simplified, that is, the microcircuits can be made by leaving the microfluids in the opposite direction. The transparent body is connected to the pipeline through the control point of the body element to allow fluid flow. The L-body 7G is controlled, whether the four, the control fluid element, the white fluid, allows the flow | the component and the microtubule i. Microfluidic element 4 To determine the direction of the flow I plane. In addition, the present invention further provides an array-type multi-directional logic control system. By designing a complex array of multi-directional logic formulas on the substrate, the flow =

557284

The system is made up of two microfluidic elements connected by micropipes to form each other .: Zhanzhixi direction logic type microfluidic control *, system. In this way, you can enter different fluids in different fluid J pieces, and make them move to any microfluidic element ... = direction. Finally, ‘the individual fluids can be mixed into the shared micro./melon body 7G arbitrarily’ or the number of micro-channels connected to the micro-fluidic components can be increased, and more than four fluids can be mixed. For example, it can cooperate with digital signal processing processor) or pr0grammabie logic (Pntaiiers, plcs) to control the microfluidic control points of each micro-pipeline, that is, it can perform more complex and multiple fluid movements. . [Embodiment] The multi-directional logic type microfluidic control system and its method disclosed in the inventions can be applied to any fluid driving method, such as piezoelectric, electromagnetic and thermal type. Take the microfluidic driving device formed by the microactuator as an example, and the microfluidic reaction zone is used as the microfluidic element for fluid reaction. Please refer to FIG. 1, which is a schematic diagram of a multi-directional logic microfluidic controller according to a first embodiment of the present invention. It is formed by a substrate 100 and four microfluidic driving devices 300. The flow system is filled in the microchannel 12 of the substrate 1 00. The design of the substrate 2 has a microfluidic reaction zone 110 and four microchannels 120. The micropipeline 120 is used to connect the four plane directions of the microfluidic reaction zone, i.e., the microfluidic reaction zone is the origin. The positive and negative X directions and the positive and negative γ directions form a cross-shaped passageway through which fluid can pass, and the fluid reaction zone i 0 flows back and forth. Its microfluidic drive = clothing 1 3 0 is installed corresponding to each microchannel 120, which is composed of a microactuator and an elastic film. The elastic film is adhered to the substrate to isolate the microchannel from microactuation.

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ί 田 微 致, the device applies pressure back and forth through the elastic film to push the elastic film in a similar manner to a diaphragm; when a micro-actuator applies pressure to the film, the film protrusions block the fluid from passing, and the micro-actuator relaxes the film Due to the elastic recovery of the film itself, I7 allows the liquid to pass through. In summary, the present invention determines the flow direction of the fluid by controlling the passage of the micro-fluidic gripper in the four plane directions by controlling the microfluidic reaction zone. Using the characteristics of the cross array, the microfluidic driving device for driving three of the four microtubules of the microfluidic reaction area in the direction of the plane to control the microfluidic driving device is to block the fluid from passing through and provide a reverse thrust, so that the fluid is directed toward the rest. Direction flow.

In addition, the present invention further provides an array type multidirectional logic microfluidic control system: please refer to FIG. 2, which is a schematic diagram of a multidirectional logic microfluidic control system according to a second embodiment of the present invention. Design four sets of multi-directional logic ^ microfluidic controllers on the substrate, including the first microfluidic reaction zone, u, the second microfluidic reaction zone, 11, the third microfluidic reaction zone, and the fourth microfluidic. The reaction zone Π4 'is used to interconnect the micropipe 120 and the microfluidic driving device 130 provided in the micropipe 120. With the first microfluidic reaction zone 111 as the origin, the first microfluidic reaction zone 111 is connected to each other via the micro-pipe in the negative X direction and the second microfluidic reaction zone 112, and is connected to the micro-pipe in the negative γ direction.丨 2 0 and the third microfluidic reaction zone 11 3 are connected to each other; and the fourth microfluidic reaction zone 11 4 is connected to each other via the micro-pipe 1 2 0 in the positive γ direction and the second microfluidic reaction zone 11 2, and 纟a is connected to each other by the micro-tubes 1 2 0 in the positive X direction and the third micro-fluid reaction region 113. In order to form a multi-point cross-array type multi-directional logic microfluidic control system. Such as

In this way, different fluids can be injected into different microfluidic reaction zones, and they can flow in any direction of the microfluidic reaction zones. For example, the control is located in a microchannel

557284 V. Description of the invention (5) 120 of the microfluidic driving device 130 'The fluid stored in the second microfluidic reaction zone 112 and the third microfluidic 1 1 3 reaction zone is driven by three points to the first fluid. When the microfluidic reaction region 111 flows, the fluid can be mixed in the first microfluidic driving region 111. It can be seen that the present invention can be further widely applied to the mixing and control of multiple fluids, and can be combined with digital signal processing and processing (DSP) to control a microfluidic driving device. Loading a program into a controller can simultaneously perform multiple operations. Point control. Or with a programmable logic controller,

(programmable logic cont]: ollers (PLCs) to control the microfluidic driving devices of each micro-technical channel to perform more complex and multiple fluid motions: In order to control the fluid mixing state by programming, multi-directional logic bodies can be The controller enters the high state when fluid enters! The state where no fluid enters ^ L is set to a low state of 0. In conjunction with the fluid numerical simulation design of the fluid inlet and outlet, the fluid can be controlled logically, which simplifies the complexity of fluid control. In addition, the design of the corpus callosum components on the micro-channel and the substrate can be equal, and the elastic space of the j should be large. If it is designed to make the = microfluidic controller mix more than four fluids, set the four micropipes and the microfluidic driver to be connected to the microfluid to be mixed. The angle between adjacent micropipes is less than 90 degrees. Anything mentioned above is 'only the preferred embodiment of this creation: to limit the scope of implementation of this creation; that is, all claims based on this creation: equal changes and modifications of the work' are within the scope of the creation patent Covered. All

Page 557284 Brief Description of the Drawings Figure 1 is the intent of the multi-directional logical microfluidic control of the first embodiment of the present invention, and Figure 2 is the multi-directional logical microfluidic control of the second embodiment of the present invention System diagram. [Illustration of Symbols]

100 Substrate 110 Microfluidic reaction zone 111 First microfluidic reaction zone 112 Second microfluidic reaction zone 113 Third microfluidic reaction zone 114 Fourth microfluidic reaction zone 120 Microchannel 130 Microfluidic driving device

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Claims (1)

557284 6. Scope of patent application 1. A multi-directional logic microfluidic control method, the steps include: providing a substrate, the substrate having a plurality of micro-channels and a plurality of micro-channels formed on the same plane; Filled in the micro-pipe, the micro-pipe is connected to the micro-fluidic element; a plurality of micro-fluid control points are provided, and each of the micro-pipes is installed with a micro-fluid control point, which is used to control the fluid of the micro-pipe Flux; control the microfluidic control point of the micro-pipe so that the micro-pipe in a predetermined flow direction of the fluid allows fluid to pass through the plurality of micro-pipes connected to the fluid element, and the micro-pipes in a non-fluid predetermined flow direction are not Passing the fluid causes the fluid to flow in a predetermined flow direction of the fluid. 2β The multi-directional logic microfluidic control method according to item 1 of the scope of the patent application, wherein the microfluidic control point is composed of a microactuator and an elastic film. The elastic film is adhered to the substrate to be separated from the substrate. Between the micro-channel and the slave actuator, the micro-actuator applies pressure back and forth through the elastic film to make the elastic film move in a manner similar to a diaphragm. 3. The multi-directional logical microfluidic control method described in item 1 of the scope of the patent application, wherein the plurality of micropipes are connected to the four plane directions of the microfluidic element, that is, the positive and negative X directions with the microfluidic element as the origin. And positive and negative directions to form a cross-shaped passage that allows fluid to flow through the microfluidic reaction zone and flow back and forth. 4 »—A multi-directional logic microfluidic controller, comprising: a substrate 'having a microfluidic element and a plurality of microchannels formed on the same plane, and the fluid is filled in the microchannels, and the material is generally ^ Connected to the microfluidic element; " Page 11 557284 VI. Scope of Patent Application A plurality of microfluidic control points, each of which is equipped with a microfluidic control point 'is used to control the fluid flux of the microchannel. 5. The multi-directional logic microfluidic controller as described in item 4 of the scope of the patent application, wherein the microfluidic control point is composed of a micro-actuator and an elastic film. The elastic membrane is adhered to the substrate to Between the micro-channel and the micro-actuator, the micro-actuator applies pressure back and forth through the elastic film to make the elastic film move in a manner similar to a diaphragm. & 6. The multi-directional logic microfluidic controller as described in item 4 of the scope of patent application, wherein the plurality of micro-channels are connected to the four plane directions of the microfluidic element, that is, the microfluidic element is used as the origin The positive and negative χ directions and the positive and negative Υ directions form a cross-shaped path that allows fluid to flow through the microfluidic reaction zone and flow back and forth. & 7. A multi-directional logic microfluidic control system, comprising: a substrate having more than one microfluidic element and a plurality of microchannels formed on the same plane, the microfluidic element passing through the microchannel Connected to each other, the fluid is filled in the micro-channel; a plurality of micro-fluid control points, each of which is installed with a micro-body control point, is used to control the fluid flow of the micro-channel, through the fluid The fluid flux and the flow direction are determined by the fluid flux of the micro-pipe connected to the mother-fluid element. 8. The multi-directional logical microfluidic control system as described in item 7 of the scope of patent application, wherein the microfluidic control point is composed of a micro-actuator and an elastic film, and the elastic film is adhered to the substrate to Between the micro-channel and the micro-actuator, the micro-actuator is reciprocated through the elastic film. Page 12 557284 6. Applying pressure in the scope of the patent application causes the elastic film to move in a manner similar to a diaphragm. 9 · The multi-directional logic microfluidic control system as described in item 7 of the scope of the patent application, wherein the plurality of microchannels are connected to the four plane directions of the microfluidic element, that is, the positive and negative points of the microfluidic element as the origin The X direction and the positive and negative Y directions form a cross-shaped path that allows the fluid to pass through the microfluidic reaction zone and flow back and forth. I. The multi-directional logic microfluidic control system as described in item 7 of the scope of patent application, which further includes a digital signal processing processor (j) Sp), which is used to control the microfluidic control of each microchannel point. II · The multi-directional logic microfluidic control system as described in item 7 of the scope of the patent application, which further includes a programmable logic controller (programmable logic controllers, ρτγ〇λ), which is used to control the mother-microcontroller. The microfluidic control point of the pipeline.