TW200412324A - Multi-directional logic micro fluid control system and method - Google Patents

Abstract

Disclosed is a multi-directional logic micro fluid control system and method, which determines the directions and numbers of fluid flows to be mixed by controlling whether or not fluids in micro-channels connected to a micro fluid member flows through the channels. That is, in a plurality of micro-channels that is connected to the fluid member, fluids are allowed to flow through the micro-channels that are in the direction along which the fluid is to flow, while fluids are prevented from flowing through the micro-channels that are not in the direction along which the fluid is to flow. A system accommodating the above method to controller loaded with a program allows more complicated fluid movement.

Description

200412324 V. Description of the invention '-[Technical field to which the invention belongs] f Mo Mingyu relates to a fluid control system and method, especially to a multi-directional logic microfluidic control system and method [prior art] Eight batches of t With the development of micro-total analysis systems (Micro T0Ul Analysis), which can be widely used in combinatorial chemistry, genomic and proteomic technologies, the development of analytical instruments and systems has also grown. A new era of magnitude. The micro-total analysis system integrates the experiment: L or general chemical reaction on a small wafer, for example, the large: matter-Η: mass fragment: end is fixed on the surface of the wafer, and in a similar manner, the wafer I and various There is an interaction between the two specimens. This experiment requires some fluid processing steps to make the micro-total analysis system

The C t effect allows the substance in the wafer to react with the sub- F-knife entering the wafer. It is difficult to automate fluid mixing and flow without liquid handling and equipment. Yu: A 3 /, the mixed flow device was born to solve the problem of fluid processing: body drive

= Body & drive devices are mostly unidirectional or bidirectional flow theory% pu (Mechanic mi cropumps) and non-mechanical micro-cooking U-type (n〇niechanic micropups). Lack of intelligent flow For more complex biochemical reactions and detection and analysis = system: in-process control of the mixing and reaction steps of the required fluid.鸡 I chicken is completed in one time. Therefore, in today's technology, the complex and automated testing of micro-total analysis systems has become an important issue. However, the pump technology can not meet this demand. In the current /, it is necessary to design other Jane 200412324

Easy fluid control methods respond. SUMMARY OF THE INVENTION In view of the above-mentioned conventional techniques, the interrogation microfluidic control system and its method are directed to the purpose of mixing. : The present invention provides a multi-directional logic to achieve effective control of the microfluid flow side π. In order to achieve the above purpose, the present invention includes a multi-directional logic microfluidic control, which is formed by a substrate and a plurality of microfluidic control points. Among them, the fluid is filled / maintained in the substrate pipe. The present invention is relatively special in the design of the substrate-(Substrate) 'which has a microfluidic element and a plurality of microchannels' The microchannel system and the microfluidic element form the same plane and are connected to the microfluidic element, each The micro-piping system is installed with a micro-fluidic control micro-fluid to control the passage of fluid. ^ u Through this simple design, the present invention can control and drive the fluid in the micro-pipes of the substrate in a simple and effective way, that is, the micro-pipes connected to the fluid element, the micro-pipes in the predetermined flow direction of the fluid allow the fluid The micro-channels passing through the non-fluid predetermined flow direction do not allow the fluid to pass through, so that the fluid flows in the predetermined fluid flow direction. For example, microfluidic elements and microchannels can be formed into cross-shaped passages for fluids to flow back and forth. The flow direction of the fluid is controlled by controlling the passage of fluid through the microfluidic elements connected to the four micro-pipes in the plane direction. By using the characteristics of the cross array, the microfluidic control points in three of the micropipes of the four-direction steam pipes of the fluid element are controlled to block the passage of the fluid, so that the fluid can flow in the remaining direction. a In addition, the present invention further provides an array-type multi-directional logic microfluidic control system. By designing a complex array of multi-directional logic-type microfluids on a substrate,

200412324 V. Description of the invention (3) Controller, each-Λ-multi-point, multi-direction, and two lines are interconnected by micro-pipes to form a microfluidic element Ϊ 2 fluid control system. In this way, 'it can flow in different component directions. At least 2 no, fluid, and can be made to any microfluidic element fluid element: You can arbitrarily mix individual fluids in a shared micro-element, which can increase the number of micro-channels connected to the micro-fluidic element. Number and more of the above fluids mixed. For example, in conjunction with a digital signal processing processor (Dsy) or a programmable logic controller (pr mable control 1er ^ όι n \ ^ > PLCs) to control the microfluidic control points of each micro-channel, you can Order more complex and diverse fluid motion. p [Embodiment] method, 0 = multi-directional logic type microfluidic control system and its variants, etc. disclosed in the Ming ^ used for any fluid drive method, such as piezoelectric, electromagnetic and thermal Θ ^ As an example, a microfluidic driving device is used, and a microfluidic element that performs a fluid reaction with the microfluid 2 ′ 2 is used. Please refer to FIG. 1, which is a schematic diagram of the multi-directional logic microfluidic controller of the first embodiment. It is formed by a substrate 100 and four microfluidic driving devices 丨 30. ^ Is filled in the micro-channel 120 of the substrate 100. The design of the substrate is based on the body reaction zone 11 〇 and four micro-pipes 120, the micro-pipes 12 are used to connect: the four plane directions of the cargo fluid reaction zone 110, that is, the micro-fluid reaction 2, Turn the positive and negative X directions and the positive and negative Y directions of the origin to form a cross-shaped path that allows the fluid to move in the opposite direction, the application zone 110, and flow back and forth. Its microfluidic amine 2 and 0 series. Corresponding to the installation of each microchannel 120, consisting of microactuators and elastic readers, elastic film is adhered to the substrate to isolate the microchannels from microactuation

Page 7 200412324 V. Description of the invention (4) For the 'micro actuator, the elastic diaphragm is used to move in a manner similar to a diaphragm; when the pressure is used to push the elastic film, the film is raised to resist resistance = pass; = pressure is Due to the elastic recovery of the film itself: When the actuator relaxes the film, π 丨 王 尤尤 itan makes the liquid pass through. The system connects the four planes through the control of the microfluidic reaction zone, the extraspleen and the flow direction of the body. Using a cross array, one of the four micro-pipes in the direction of the body reaction zone ^ = micro-body driving device 'is controlled to block the passage of fluid and provide a -reverse: thrust, so that the fluid flows in the remaining direction. In addition, the present invention further provides an array-type multi-directional logic :: system, please refer to FIG. 2, which is a multi-faceted body of the second embodiment of the present invention: Ϊ = schematic diagram of the manufacturing system. Design four on the substrate Set of multi-directional logic, U body tethering device, which contains the first microfluidic reaction zone 丨 丨 丨, the second t ::, the reaction zone 11 2, the third microfluidic reaction zone 11 3 '帛 four microfluidic reactions Zone Π4, micro-channels 120 for interconnecting each other, and a body driving device 130 provided in the micro-channels 120. With the first microfluidic reaction zone U1 as the origin, the first micro; The micro-channel in the negative X direction, 20 and the second microfluidic reaction zone 112 are connected to each other, and are connected to each other via the micro-tube 120 in the negative γ direction and the third microfluidic reaction zone 113, and the fourth microfluidic reaction zone, 11 4 is the phase of the micro-tube 120 and the second microfluidic reaction zone 112 via the positive γ direction. They are connected to each other and connected to each other via the positive political direction pipe 120 and the third microfluidic reaction zone 113 to form a multi-point cross-array type multidirectional logical microfluidic control system. In this way, it can be used in different Different fluids are injected into the microfluidic reaction zone, and they can flow in any direction of the microfluidic reaction zone. For example, 'control is set in the microtube ζ

Page 8 200412324 V. Description of the invention (5) 1 2 0 microfluidic driving device 1 3 0 'The fluids to be stored in the second microfluidic reaction 1 1 2 zone and the third microfluidic 1 1 3 reaction zone are divided into three The point-driven manner causes the fluid to flow to the first microfluidic reaction region 111, so that the fluid can perform a mixed reaction in the first microfluidic \ drive region 111. It can be seen that the present invention can be further widely applied to the mixing and control of multiple fluids, and can be combined with digital signal processing (DSP) to control a microfluidic driving device, and a program can be loaded into the controller to perform multi-point control. . Or with the programmable logic controller $ (programmable lOgic controllers, pLCs) to control the microfluidic driving device of the channel, you can perform more complex and diversified flow narrators in cooperation with the program to control its fluid mixing state, can Will be multi-directional, wordy, ... The state that the fluid controller enters the fluid is set to the high state 1, & the fluid enters the ear " shout flow: is the low state. 'With the fluid numerical simulation of the fluid inlet and outlet, the physical and logical control is simplified to simplify the complexity of fluid control. Therefore, the microfluidics and microfluidic components on the substrate are designed to be flexible.' Big. If you need a spring "body controller, you can perform four or more fluid mixing two-way logic testers. This is connected to the microfluidic actuator α ==, and the angle between the above adjacent microchannels is less than 90 degrees .... The author of this book is only a better example of this creation. You Ru used to limit the creation of Zhan Fen # μ m / T 幻 汉 乂 1 Tu Bei example, the equal change of Long Kong's work 2: Taiben creation The patent application Fan Yi t ornaments are all covered by the scope of the creation patent

Page 9 200412324 Brief Description of the Drawings Figure 1 is a schematic diagram of a multidirectional logic microfluidic controller according to the first embodiment of the present invention; and Figure 2 is a multidirectional logic microfluidic control system according to the second embodiment of the present invention schematic diagram. [Symbol description] 100 substrate 110 microfluidic reaction zone 111 first microfluidic reaction zone 112 second microfluidic reaction zone

113 Third microfluidic reaction zone 114 Fourth microfluidic reaction zone 120 Microchannel 130 Microfluidic driving device

Page 10

Claims (1)

200412324 VI. Scope of patent application 1. A ^ -direction logic type microfluidic control method includes the following steps: Provide a substrate. The substrate has a microfluidic element and a plurality of microchannels formed on the same plane. Filled in the micro-channel, the micro-channel is connected to the micro-fluidic element, and provides a plurality of micro-fluid control points, each of which is equipped with a U fluid control point, which is used to control the micro-channel fluid Flux; control the microfluidic control point of the microchannel so that among the plurality of microchannels connected to the fluid element, the microchannel in the predetermined flow direction of the fluid allows fluid to pass through, and the microchannels in the non-fluid predetermined flow direction are not Passing the fluid causes the fluid to flow in a predetermined flow direction of the fluid. 2 * 11 The multi-directional logic microfluidic control method described in item 1 of the Ming Li Range, wherein the microfluidic control point is formed by a micro-actuator and an elastic thin film, and the elastic film is adhered to the substrate to Separated between the micro-pipes, the micro-actuator applies pressure back and forth through the elastic film to make the elastic film operate like a diaphragm. I: Please surround the multi-directional logical microfluidic control surface described in item 1. ;: The micro-pipeline is connected to the fourth part of the micro-back body element: the "face direction", that is, the positive and negative X directions with the micro-fluidic element as the origin, to form a flow of fluid that can pass through the micro-fluid reaction zone and back and forth. Type pathway. A multi-directional logic type microfluidic controller includes two substrates, which are formed on the same plane: a microfluidic element and a wood micropipeline; a fluid is filled in the micropipeline as a towel; the micropipeline system Connected to the microfluidic element; 4. 200412324 VI. Patent application scope Multiple microfluidic control points' Each of the micropipelines is installed with a microfluidic control point for controlling the fluid flux of the micropipeline. 5. The multi-directional logic microfluidic controller according to item 4 of the scope of patent application, wherein the microfluidic control point is composed of a micro-actuator and an elastic film, and the elastic film is adhered to the substrate to isolate Between the micro-channel and the micro-actuator, the micro-actuator reciprocates the pressure through the elastic film to make the elastic film move in a manner similar to a diaphragm. 6 · The multi-directional logic microfluidic controller as described in item 4 of the scope of the patent application, wherein the plurality of microchannels are connected to the four plane directions of the microfluidic element, that is, the positive and negative of the microfluidic element as the origin The X direction and the positive and negative Y directions form a cross-shaped path that allows fluid to flow in and out of the microfluidic reaction zone. 7 · A multi-directional logic type microfluidic control system, comprising: a substrate having more than one microfluidic element formed on the same plane and a plurality of microchannels, and the microfluidic elements communicate with each other through the microchannels The fluid is filled in the micro-channel; t a plurality of micro-fluid control points' mother-the micro-channel is installed with _ micro-fluid control points, which is used to control the fluid flow of the micro-channel, The fluid flux and flow direction are determined by the fluid flux of each of the micro-pipes connected to the micro-milk element. " " And 8. The multi-directional logical microfluidic control system as described in item 7 of the scope of patent application, wherein the microfluidic control point is composed of a micro-actuator and an elastic film, and the elastic film is adhered. The substrate is separated between the micro-channel and the micro-actuator, and the micro-actuator is reciprocated through the elastic film 200412324 6. Scope of patent application 9: Lishen The elastic film moves in a similar way to the diaphragm. . Contesting consumes as much as described in item 7, to the logical microfluidic control surface = the plurality of microchannels connected to the four-flow L cross of the microfluidic element so that fluid can pass through the microfluidic reaction zone and back and forth. The multi-directional logic microfluidic control described in item 7 further includes a digital signal processing processor, which is used to manufacture the microfluidic control point of the female microtubule. U, as described in the scope of application "Multi-directional logical microfluidic control system" which further includes a programmable logic control cry (prog ^ a bandabie ^ ogw controllers, pLCs °°), It is used to control the microfluidic control point of the parent microtubule.