TW520286B - Skin whitening composition - Google Patents

Abstract

The composition has a skin whitening blend. The skin whitening blend has a hypopigmenting component and an antioxidant. The skin whitening blend may also have an accelerant that enhances or accelerates the skin cell turnover rate. The skin whitening blend may also comprise the hypopigmenting component, the antioxidant and a sunscreen, or all three ingredients and the accelerant.

Description

V. Description of the Invention (1) Relevant Application This application is a partial continuation application of the US application serial number 09 / ⑽, 107 filed on June 30, 1998 and the current trial order, which is based on April 29, 1998. The US Provisional Chinese Serial No. 6 and 3 filed on the basis of Japan and applied for a patent based on its priority. TECHNICAL FIELD OF THE INVENTION The present invention relates to a new skin lightening blend, which is a synergistic composition of a low pigmentation component and an antioxidant. The f skin whitening blend is incorporated into a stephena-a suitable topical vehicle to provide-a skin lightening composition. Optionally, the skin whitening blend may also include a sunscreen and / or a skin cell regeneration rate promoter. An object of the present invention is to provide an effective skin whitening blend comprising a low Pigmented ingredients with an antioxidant. Another object of the present invention is to provide an effective skin lightening blend, which further comprises a sunscreen agent and / or a skin cell regeneration rate promoting agent. Another object of the present invention is to provide an effective skin-whitening composition which incorporates the skin-whitening blend of the present invention in a pharmaceutically excellent local carrier. Another object of the present invention is to provide an effective skin lightening composition 'which is a cream. 4 This paper size applies to China National Standard (CNS) A4 specifications (210 X 297 ^ 7 ^ 0286 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (2) Another object of the present invention is to provide two An effective skin whitening composition, which is an emulsion, solution, hydroalcoholic liquid, powder, moisturizer or skin patch. DESCRIPTION OF PREFERRED EMBODIMENTS The present invention relates to a skin lightening blend (hereinafter referred to as " Skin lightening blend), which is contained in a suitable topical vehicle to form the overall skin lightening composition of the present invention. Unless otherwise defined, the percentages disclosed herein are the overall skin lightening composition (Hereinafter referred to as "composition") by weight. Topical carriers suitable for use in the present invention include creams, lotions, solutions, hydroalcoholic liquids, body creams, powders, and skin patches. The activity of the composition / Efficacy is defined here as lightening skin tone, homogenizing skin tone / color, reducing the appearance of sun spots (age spots) or sweat spots (freckles), reducing dark spots, reducing brown spots, reducing Excessive hyperpigmentation after inflammation, reducing pigmentation-type keratosis, and / or reducing any damage caused by sun exposure. The first specific example of the present invention is a composition having a skin-whitening exchange agent The skin whitening blend has a low pigmentation component and an antioxidant. In a second specific example of the present invention, the skin whitening blend has a component that enhances or accelerates the rate of skin cell regeneration (Hereinafter referred to as "accelerator".) In the third specific example of the present invention, the skin whitening blend has a low pigmentation component, an antioxidant, and a sunscreen, and the fourth specific example has all The three ingredients plus this paper size are applicable to Chinese national standards (CNSM_4 specifications ⑵〇x 297 public Ding -------------- installed -------- order ---- ----- Line (Please read the precautions on the back before filling this page) 520286

Accelerator of the second specific example. The low-pigmentation ingredients used in all four specific examples include the following: ⑴ a licorice extract; (ii) a natural extract containing at least one of the following extracts: witch hazel tannin, mulberry, tiger ear Grass, Scutellaria baicalensis, grapes, chlorella, bilberry, bilberry, bilberry, molasses, pear, guava or mixtures thereof; and (iii) licorice extract as defined in ⑴ and as described in (11) One of the definitions is a natural extract blend (hereinafter referred to as, natural extraction permeate). Concerning natural extracts (ii) ’When used alone, any natural extract has low pigmentation activity. However, in order to reduce the skin tone desired by the user, the natural extract is preferably a mixture of at least two extracts selected from the group consisting of witch hazel tannin, mulberry, saxifraga, scutellaria baicalensis, grapes , Chlorella, bearberry, bilberry, bilberry, molasses, pear, and guava (hereinafter referred to as "natural extract mixture"). In a second preferred embodiment, the natural extract mixture has pear and guava extracts. In a more specific embodiment, the natural extract mixture has all of the following extracts: witch hazel tannin, mulberry, saxifraga, scutellaria baicalensis, grapes, chlorella, canola, bilberry, bilberry, and molasses . In a preferred embodiment, the natural extraction mixture has the following extracts: Witch Hazel Tannin, Mulberry, Saxifraga, Scutellaria baicalensis, Grape and Bearberry. When the extract is a mulberry extract or tiger ear extract, it is preferred that at least part of the extract is taken from its root. When the low pigmentation component has a licorice extract, this paper can be used. Standards are applicable to China National Standard (CNS) A4 (210 X 297 mm) ----------- I ^ --- (Please read the note on the back? Matters before filling out this page} 2. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 6 520286 A7 ^ ---- B7 ------------ 5. Description of the invention (4), use of a water-soluble (or water-containing) or a Oil-soluble licorice extract. (Please read the notes on the back before filling out this page) Examples of suitable water-soluble licorice extracts are hydroxy-licorice extract, alcohol-type licorice extract, and combinations thereof. If water-soluble licorice is used The extract of "Ganzhuo extract" is about 0.001% to 30% by weight. The oil-soluble licorice extract is a better licorice extract. Preferably, the oil-soluble licorice extract is a powder Form, and about 0.001% to 5.0% by weight of the composition, more preferably about 0.02% to 1% by weight 0% by weight. Even more preferably, the oil-soluble licorice extract is about 0% to 0.2% by weight of the composition. The most preferable is that the oil-soluble composition is about 0.05% by weight to 0.1 of the composition. % By weight. The oil-soluble licorice extract may have one or more of the following ingredients: glabridin, giabrene, 7-Cyclo-4,-oxo-isoflavone, glabra ( glabrol) and other related phenolic compounds. Examples of the compounds may include hisPaglabridin-A, 4, -o-methylglabridin and 3, _hydroxy- 4'-o-methyl gabfidin. The low-pigmentation component of the printed agricultural product printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs is preferably licorice extract. The low-pigmentation used for this composition The composition is more preferably natural extract blend (iii) (which includes both licorice extract ⑴ and natural extract (ii)). However, the composition with low pigmentation is even more preferably licorice extract ⑴ Preferred specific example and better first specific example of natural extract mixture (Π) Composition. The composition of the low pigmentation is preferably the combination of the best specific example of the licorice extract ⑴ and the best first specific example of the natural extract mixture (ii). This paper size applies the Chinese national standard (CNS ) A4 size (210 x 297 mm) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 520286 A7 _ B7 V. Description of the invention (5) If the composition of the low pigmentation is a natural extract as defined in (ii) The natural extract mixture has at least two types of the following extracts, which are about 0.01% to 99% by weight of the mixture: witch hazel tannin (Hamamelis virginiana), mulberry , Saxifraga, yellow answer, grape, Chlorella vulgaris, Arctostaphylos uva ursi 'Vaccinium vitiQ, Vaccinium myrtillns, molasses (black sugar). The second example of the natural extraction mixture has about 0.1% to 99% by weight of witch hazel tannin extract, and about 0.01% to 99% by weight of each of the following extracts: mulberry, saxifraga, scutellaria , Grapes and bear berries. More preferably, the second example of the natural extraction mixture has about 5% to 30% by weight of witch hazel tannin extract, and about 0.1% to 10% by weight of each of the following extracts: mulberry, saxifraga , Scutellaria baicalensis, grapes and bear berries. The third example of the natural extraction mixture has a witch hazel tannin extract of about 0.1% to 99% by weight, and about 0.01 to 99% by weight of each of the following extracts: mulberry, saxifraga , Scutellaria baicalensis, grapes, chlorella, bearberry, bilberry, bilberry and molasses. More preferably, the third example of the natural extraction mixture has about 5% to 30% by weight of witch hazel tannin extract, and about 0.1% to 10% by weight of each of the following extracts: mulberry, tiger ear Grass, Scutellaria baicalensis, Grape, Chlorella, Bearberry, Bilberry, European Bilberry and Molasses. A fourth example of the natural extraction mixture has a pear extract of about 0.01% to 99% by weight, and a pomegranate extract of about 0.01% to 99% by weight. More preferably, the fourth example of the natural extract mixture has a weight of about 0.1. The paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before filling this page)

520286

Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs from 10% to 10% by weight of 1% pear extract and about 0.01% by weight to 10% by weight of pomegranate extract. The second component in all four specific examples of the present invention is an antioxidant. The antioxidant may include the following extracts: green tea, rosemary (hereafter, rosemary), oryzanol, tocopherol or tocopherol derivatives, tetrahydroturmeric pigment or mixtures thereof. When used individually, the aforementioned antioxidants are all active. The antioxidant is preferably at least two antioxidant extracts. The antioxidant is preferably a mixture of all four antioxidants. The total amount of antioxidants in the composition is about 0.0001% to 50% by weight. The green tea extract may be an aqueous, alcoholic, hydroxy, oil-miscible powder, or a combination thereof. If the green tea extract is an aqueous, alcoholic, or hydroxy type ' Then, the green tea extract is about 0.001% to 30% by weight of the composition. The green tea extract is preferably a green tea extract powder, and the lowest content of Dopan is about 65 weight of the green tea extract powder. %, And the polyphenol content includes epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). However, other additional ingredients may be included in the polyphenol content. When used As defined above When the green tea extract powder has a polyphenol content, the composition is about 0.0001% to 5.0% by weight of the green tea extract powder, and more preferably about 0.0001% to 1.0% by weight of the green tea extract powder. 〇. Rosemary extract can be water-based, alcohol-based, base-based, oil-miscible powder 'or a combination thereof. Rosemary extract is about 0 001% by weight to 30 This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm)

9 Amount / 〇 About 92% by weight to 98% by weight of dry powder oil-miscible oils of late rosemary is preferred. When the oil-miscible rosemary extract powder is used, the composition is about 0.001% to 15% by weight of the rosemary extract powder, and more preferably about 0.05% by weight of the rosemary extract powder. The antioxidant may also have about 0.001% to 15% by weight, more preferably about 0.01% to 5% by weight of oryzanol. The antioxidant composition further comprises about 0.01 to 10% by weight, more preferably about 0.01 to 5% by weight of tocopherol or tocopherol derivative. Examples of suitable tocopherol derivatives are vitamin E acetate, vitamin E nicotinate, and vitamin E linoleate. Tetrahydrocurcumin is a preferred antioxidant. In a preferred embodiment, ' tetrahydrocurcumin is present in an amount of about 0.001% to 20% by weight. In a more specific embodiment, the tetrahydrocurcumin is present in an amount of about 01% to 10% by weight, and the most optimal is present in an amount of about 0.5% to 5% by weight. The antioxidant of the present invention preferably includes a tetrahydroturmeric pigment. It was found that the skin lightening composition of the present invention has both a low-pigmentation blend of tetrahydroturmeric pigment and a natural extract when compared to a low-pigmentation blend of tetrahydroturmeric pigment or a natural extract, respectively. It exhibits an unexpected synergistic whitening / depigmentation activity. A live comparison test of three skin whitening compositions was performed to measure the production of skin pigmentation after exposure to 1 MED (minimum erythema dose). The active components of Samples A, B, and C are listed below. 10 This paper size applies the Chinese National Standard (CNS) A4 specification (2) 0x 297 public love) 520286. Α7 Β7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (8) Sample A 3.6.9- Trioxundecanoic acid vitamin E acetate γ-oryzanol rosemary extract powder licorice extract (oil-miscible powder) green tea extract powder mulberry extract powder bearberry extract powder witch hazel tannin extract Saxifraga extract Grape extract Mulberry root extract Scutellaria baicalensis root extract sample B 3.6.9- Trioxaundecane diacid vitamin E acetate γ-Ivytin rosemary extract powder licorice extract (Oil-miscible powder) Green tea extract powder, mulberry extract powder, bearberry extract powder (please read the precautions on the back before filling out this page) This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 11 520286 A7 B7 V. Description of the invention (9) Grape extract _ Mulberry root extract Scutellaria baicalensis root extract Tetrahydrocurcumin sample C Tetrahydrocurcumin control group Take samples A, B or C Organize the skin area of human Gu Cangbei, and then expose it to light equivalent to 1 (lowest erythema dose). The test area was observed for a period of 8 days, and daily observations were performed from days 4 to 8. The test results are shown in Table 1 below. Table 1 Process of action; t * * (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Control group 0.5 Sample A 0.2 Sample B 0.1 Sample C 0.3 ** The degree of pigmentation observed decreases with decreasing values, that is, the degree of pigmentation of 0.3 is less than 0.5. The results shown in Table 1 show that the tetrahydroturmeric pigment present in the skin whitening composition of the present invention produces more tetrahydroturmeric pigment than the skin whitening composition without tetrahydrocurcumin or the tetrahydrocurcumin itself, The paper size of the table is not expected to apply the Chinese National Standard (CNS) A4 specification (210 X 297 public love ϋ I ^ OJ1 ϋ n I «I ϋ n II 520286. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (1¾) Synergistic whitening effect. Include == No .: In the specific example, the skin whitening blend step-up rate A 4 promoter helps to increase the rate of skin cell renewal = strengthen the No. 1 -Specific of the invention Examples of skin whitening activity. Examples of oxa r ,, rM are oxa acids and oxa diacids (hereafter also retinoids and retinoid derivatives, which are preferably 1 see: alcohol derivative Preferably, the composition has an accelerator of about 2 to 10 weight. If the accelerator is a retinol or a retinol derivative, then the composition has a weight of 1 to 5 weight percent. % ^ See reading or retinol projectiles. If this promotes It is a kind of visual pigment, a color reading organism, and an occupational color record is preferably a visual material or a kind of spectroscopy; a promoter is a kind of oxa acid or an oxa acid complex. The material preferably has about 0.5 to 10% by weight of oxalic acid. The oxalic acid suitable for the present invention is disclosed in the co-examined US patent application serial numbers _6,54Q and _58, _. Each of the aforementioned patents The entire solution of the Chinese patent application is incorporated here, and is incorporated herein as reference material. If an oxa acid is used, the composition preferably has about 3,6,9_ of about 0.5% to 10% by weight of oxygen. In addition, if the surface of the accelerator is _ a kind of oxa acid or oxa acid-composition, the acid test value of the composition is preferably about 3.5 to 4.5. Three specific examples have a composition with low pigmentation, wounds, antioxidants, and further contain _ sunscreen agents. The warming agent may be any sunscreen agent or two or more sunscreen agents known in the art to be suitable for local composition. This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

I I I I --- (Please read the notes on the back before filling out this page) · -line · 13 520286 A7

5. Description of the invention (11) A combination of sunscreen agents. The sunscreen is about 0.001% to 40% by weight of the composition, and more preferably about 3% to 25% by weight. Examples of suitable sunscreens for employees of the Intellectual Property Bureau of the Ministry of Economic Affairs, Consumer Cooperatives, and their suitable concentrations are as follows: about 0.001% to 10% by weight of ethylhexyl p-methoxycinnamate (suitable ethyl cinnamate) Non-limiting examples of p-hexyl esters are those obtained under the trade name "Parsol MCX" from Givaudan Corporation, and under the trade name "Escalol 557" from Van Dyk Incorporation, under the trade name "Neo Heliopan Αν ”obtained from Haarman & Reimer Corporation and obtained from BASF under the trade name“ Uvinul MC80 ”); about 0.0001% to 10% by weight of oxybenzone or benzophenone- 3 (Non-limiting examples of suitable oxyphenones are those obtained under the trade name "Escalol 567, obtained from ISP Van Dyk, under the trade name" Uvinul M40 "from BASF, under the trade name" Syntase 62 "obtained from Neville Synthese Chem./Rhone Poulenc (Rhodia) and product under the trade name" Eusolex 4360 "# 605376 (from Rona / EM Ind.); Approximately 0.001% by weight 10% by weight of sulfoisophenone; about 0.001% by weight to 3.0% by weight of dioxophenone; about 0.001% by weight to 5% by weight of o-aminophenylbenzoic acid caprylate; about 0.001% by weight to 25% by weight Titanium dioxide; about 0.001% to 20% by weight of zinc oxide; about 0.001% to 10% by weight of flavonoids or derivatives thereof; about 0.001% to 10% by weight of butylphosphonium oxybenzoylmethane ( Non-limiting example of a suitable butylmethoxydibenzoylmethane is under the trade name "Pai: sol-1789" product # 64030 (available from Roche Inc.); from about 0.001% to 10% by weight of 4--14 copies Paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 520286. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

-------------- Μ ί (Please read the precautions on the back before filling out this page) · -line · A7 _____ ^ L._ 5. Description of the invention Benzamidine methane; octyltriazinone at about 0.001 to 10% by weight; and about 0.001 to 25% by weight of one consisting of titanium dioxide, zinc oxide, and memethone A sunscreen agent produced by Miyoshi Kasei and sold by uS Cosmetics under the trade name "TZ Powder Type 1 (B)". A preferred sunscreen agent comprises about 7.5% by weight of ethyl cinnamate Methylhexyl methoxyester, about 2% by weight of butylmethoxybenzophenamyl methane, and about 3 to 4% by weight of oxybenzone or benzophenone. In a preferred fourth embodiment of the present invention, The skin-whitening blend has low-pigmentation components, antioxidants, promoters, and sunscreens. As far as the fourth specific example is concerned, the parameters of each component are the same as above. The reason why the fourth specific example is the best , Because it increases the renewal rate of skin cells through the promoter, thereby enhancing the skin beauty of the first specific case The effect and the effect of the added sunscreen are to protect the user from the damage of ultraviolet radiation. The composition of the present invention has one or more other ingredients such as alcohols, pH adjusters, chelating agents, emollients, Emulsifier, film-forming agent, wetting agent, perfume, masking agent, pigment, preservative, powder, surfactant and thickener. The pH adjuster is preferably an alkali. The alkali is preferably hydroxide Ammonium, potassium hydroxide and sodium hydroxide. Potassium hydroxide and ammonium hydroxide are preferred. In theory, other pH regulators are also suitable for the present invention. If the pH regulator can provide a stable Composition and the acid and alkali of the composition The paper size of this composition is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 15 520286 A7 B7 V. Description of the invention (Θ value is adjusted to an acid and alkali suitable for local use As mentioned above, when the accelerator is monooxa acid, the pH value of the composition is preferably about 3.5 to 4.5. The preferred composition of the present invention may have the following components: Intellectual property of the Ministry of Economic Affairs Printed by Bureau Consumers Cooperative Ingredients_ Percentage 3,6,9-Trioxaundecane diacid 0.001-10.0 Ammonium hydroxide 0.001-4.0 Wetting agent (such as ethylene glycol, glycerin) 0.5-15.0 Thickener (such as gum, starch, polymer ) 0.1-4.0 chelating agent 0.001-0.5 emollient 1.0-10.0 crushed ketone 0.1-15.0 preservative 0.01-2.0 aliphatic alcohol / emulsifier / wax / fatty acid 0.5-15.0 alcohol 0-10.0 vitamin E acetate 1.0 y -Oryzanol 0.5 Extract 12.35 Ethylhexyl cinnamate cinnamate 7.5 Butyl oxydiphenyl fluorenyl oxane 2.0 Dibenzophenone-3 3.5 Demineralized water QS The following is one of the compositions of the present invention, It was tested in a test tube and found to provide the required effective skin whitening composition. This paper size applies Chinese National Standard X 297 mm)

520286 V. Description of the invention (β Example 2 Ingredient 3,6,9-trioxaundecyl diacid ammonium hydroxide wetting agent (such as ethylene glycol, glycerin) Thickener (such as gum, powder, polymer Chelating agents, emollients, silicone preservatives, aliphatic alcohols / emulsifiers / soils / fatty acid alcohols, vitamin E acetate, gamma-oryzanol, rosemary extract, licorice extract (oil-miscible powder), green tea extract Powder mulberry extract powder bear berry extract powder tetrahydroturmeric yellow saxifrage and grape root root extract blended with ethylhexyl oxycinnamate butyl oxyn cinnamate " monobenzoyl benzophenone -3 Demineralized water percentage Mulberry root extract with yellow 0.001-10.0 0.001-4.0 0.5-15.0 〇.1-4.0 0.001-0.5 1.0-10.0 0.1-15.0 0.01-2.0 0.5-15.0 0-10.0 1.0 0.5 0.2 0.05 0.0004 0.1 1.0 1.0 1.0 7.5 2.0 3.5QS -------------- Installation -------- Order --------- (Please read the note on the back first? Matters Refill this page}. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. By reviewing this application, you will understand various improvements and changes to the present invention. The additions are within the scope and spirit of the invention as defined by the scope of the patent application below. The paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm)

Claims (1)

520286 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 6. Scope of Patent Application 1. A skin whitening composition, which includes:, a component with low pigmentation; and an antioxidant containing tetrahydroturmeric pigment. 2. The skin lightening composition according to item 1 of the scope of the patent application includes a promoter for enhancing the rate of skin cell renewal. 3. The skin whitening composition according to the scope of the patent application includes a sunscreen. A8 B8 C8 D8 further includes its further package 4. The skin whitening composition as described in the scope of patent application item 1, wherein the low pigmentation component is selected from the following group: (a)-a kind of licorice extract; ( b) a natural extract comprising at least one of the following extracts: witch hazel tannin, mulberry, saxifraga, scutellaria baicalensis, grapes, chlorella, sassafras, bilberry, bilberry, molasses, pear and Guava; and (c) a blend of the licorice extract and one of the natural extracts. 5. The skin whitening composition according to item 4 of the application, wherein the natural extract comprises a mixture of at least two extracts selected from the group consisting of witch hazel tannin, mulberry, saxifraga, scutellaria baicalensis, Grape, chlorella, berry, raspberry, bilberry, bilberry, molasses, pear and guava. 6. The skin whitening composition according to item 1 of the patent application scope, wherein the low pigmentation component is a licorice extract. 7. The skin whitening composition according to item 6 of the application, wherein the licorice extract is selected from the group consisting of a water-soluble licorice extract and an oil-soluble licorice extract. I ------------------ Order --- I ----- (Please read the notes on the back before filling this page) -18- 1 x 297 mm ) The scope of the patent application is printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 8. If the scope of the patent application is Chu-w, the skin whitening composition of item 7, where the licorice is a water-soluble licorice extract, the water-soluble licorice Extraction 2 constitutes about 0.001% to about 30% by weight of the δH composition, and when the licorice extract is an oil-soluble licorice extract, the / composed / combined extract constitutes about 0.00% of the composition. ⑽1% by weight to about 5.0% by weight 〇 • Skin whitening composition as described in item 7 of the patent scope, "The oil-soluble extract is in the form of a powder 'and about 0.2% by weight of the composition It is present in an amount ranging from% to about 1.0% by weight. 10. The skin whitening composition according to item i of the application, wherein the low pigmentation component is a combination of a licorice extract and a natural extract. U. The skin whitening composition according to item i of the patent application range, wherein the low pigmentation component is a mixture of natural extracts, and the β-hai natural extract mixture is about 0.1% by weight to 1% of a mixture. ". 0% by weight, the mixture has at least two of the following extracts: witch hazel tannin, mulberry, saxifraga, yellow tangerine, grapes, persimmon, more wilted, lingonberry or molasses. 2. The skin lightening composition according to claim 1 in the patent scope, wherein the antioxidant is about 0.0001% to about 50% by weight of the composition. 3. The skin whitening composition according to item 2 of the application for a kiss kiss, wherein the promoter is selected from the group consisting of an oxa acid, a composition of oxa acids, a retinoid, a retinoid derivative, and Its mixture. — — — — — — — — — 111! · I I I j I 1 t 111 — — — — — (Please read the notes on the back before filling out this page) -19- 520286 A8B8C8D8 VI. Application scope of patent 14. The skin whitening composition according to item 13 of the scope of application for patent, wherein the promoter is about 0.001% to about 10% by weight of the composition. (Please read the precautions on the back before filling this page) 15. If the skin whitening composition of item 1 of the patent application scope, it further includes a carrier. 16. The skin lightening composition according to item 3 of the claim, wherein the sunscreen is about 0.00% to about 40% by weight of the composition. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 17. The skin whitening composition as described in the scope of patent application No. 3, wherein the sunscreen agent is selected from the group: about 0.0001% to about 10% by weight Ethylhexyl cinnamate, p-oxoate, about 0.001% to about 10% by weight of oxybenzone or benzophenone-3, about 0.001% to about 10% by weight Sulfabenone, about 0.001% to about 30% by weight of dioxophenone, about 0.001% to about 5% by weight of o-aminobenzoic acid caprylate, about 0.001% to about 25% by weight Titanium dioxide, about 0.001% to about 20% by weight of zinc oxide, about 0.001% to about 5% by weight of flavonoids or a derivative thereof, about 0.001% by weight to about 10% by weight of butylmethoxymonobenzylfluorene, about 0.0001% to about 10% by weight of 4-isopropyldibenzofluorene, about 0.001% to about 10% by weight % Of octyltriazinone and about 0.001% to about 25% by weight of one consisting of titanium dioxide zinc oxide and mecone Sunscreens. 18. The skin whitening composition according to item 2 of the patent application scope, further comprising a pH adjuster, wherein the pH adjuster is selected from the group consisting of ammonium hydroxide, potassium hydroxide, and sodium hydroxide . 19. If the skin whitening composition of item 丨 in the scope of patent application, the paper size is further applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 issued) -20- 520286 A8 B8 C8 D8. The scope of patent application includes one Ingredients selected from the group consisting of alcohols, chelating agents, emollients, emulsifiers, film formers, wetting agents, fragrances, masking agents, pigments, preservatives, powders, surfactants and thickeners. 20. The skin lightening composition according to item 11 of the application, wherein the natural extract mixture includes a mixture having at least two of the following extracts: witch hazel tannin, mulberry, saxifraga, scutellaria baicalensis, grapes, and bearberry , Bilberry, bilberry or molasses. ------------- Equipment -------- Order · (Please read the notes on the back before filling out this page) 丨 Line-Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) -21- Yixing ^!: • ^ He-ct Ministry of Economic Affairs Zhicicai / $ Bureau 8 Industry Consumer Cooperative Co., Ltd. Printing Bulletin Application Issue, 拎 十 r 一 2 ^: 11το Case No. Total f / 2 3? From the category A ^. 〇,: 520286 No. 88123320 No. 88123320 Nominal Patent Specification Revised Date_Revision Date: June 1990 Invention of New Type Name Invention Creator Applicant Chinese and English Surname. First Name Nationality Residence, Residence Name (Name) Country Residence, Residence (Resident Affairs Office) Representative Name Skin Whitening Composition SKIN WEilTENING OCT4PQSITION Brother Stowe D. Kiru βSu Sf E. Simpson S. Fermi's Temple, Poselint, Xi Dani, M. Martin (5), Garris J. Tyr, Kyro%, Christos D. Simpson, Susan E. Ptchelintsev, Dmitri Martin, Dennis M. Teal, Janice ⑴⑵⑸ 面 ⑶ Li Feng Da (4 extinction rides (1 ^ Savannah Park, New York, USA Avenue Apartment 8〇 / of ^ 80 New York 10901 USA Wyckoflf, New Jersey 07481 USA Wyckoflf, New Jersey 07481 USA (3) Mahwan, New Jersey 668 Juniper Road, Mawa City, New Jersey, USA 07430 USA 康 Cornwall, New York, United States 8 Corney, New York 12518U.SA ⑸ 美 _93 Westport, Connecticut, 93 ~ Easlon Road, Weslpoii, CT 06880- AVON PRODUCTSS, INC. New York, New York, USA 1251 Avenue of the Americas New Yoik, NY510020-1196 US A Anthony M .. Santini Santini, Anthony M. Paper The scale is applicable to the towel home standard (CNS) Α4 size (2lQx297) m binding line