TW422855B - Multifocal optical lens, method for correcting an ametropic condition, method for providing a multifocal vision correction, method for producing a multifocal optical lens for correcting ametropic conditions, biocompatible holographic element produced - Google Patents

Abstract

The invention provides an active multifocal optical lens. The optical lens has a first optical element that provides a first optical power and a second optical element that provides a second optical power. The second optical element is a volume holographic optical element, which has been programmed to focus incoming light. The invention provides further a crosslinkable or polymerizable optical material that is suitable for producing a biocompatible holographic optical element. The optical material is a rapidly crosslinking or polymerizing material that changes from a fluid state to a solid state with in a limited duration after being exposed to a light source.

Description

4228 5 5 B7 V. Description of the invention (1) The present invention relates to a multifocal lens containing a holographic element and providing at least two optical magnifications. Various bifocal lens design concepts for ophthalmic lenses can be obtained, which are placed on or in the eye to correct visual defects, such as contact lenses and intraocular lenses. A conventional bifocal ophthalmic lens design is a concentric simultaneous vision type. Concentric simultaneous bifocal ophthalmic lenses have alternate light lift areas arranged concentrically. Concentric alternating optical areas have different radii of curvature to provide different magnifications for near and far images, so the near and far images are focused on a common area. Although concentric simultaneous bifocal lenses have been on the market for some time, they have not been widely used. This is because the images projected on the retina by the concentric and simultaneous bifocal lens are composed of near and far images, and the overlapping images make both the near and far images unable to be completely clear. For example, when looking at a distant object through a concentric simultaneous bifocal lens, the image of the near object exists at the same time, making the distant object blurred or hazy. In addition, because the light entering the concentric simultaneous bifocal lens is shared by the two optical areas, the contrast and intensity of the focused image are sacrificed, especially in low light conditions. Another conventional bifocal ophthalmic lens design is a diffractive simultaneous vision type. These lenses have a diffractive optical element and a refractive optical element, and use two optical elements to simultaneously project the far and near images on the retina. Like a cardiac simultaneous bifocal lens, a diffractive simultaneous bifocal lens splits the light entering the eye into near and far images and projects the image onto the retina simultaneously. Therefore, neither the near image nor the far image will be completely clear, and contrast and intensity problems will occur in low light conditions. Another conventional bifocal ophthalmic lens design is a conversion type. Conversion ______3 ___ (Please read the notes on the back ^^-item before filling out this page) Printed on the paper printed by the Employees' Cooperative of the Intellectual Property Bureau of the Ministry of Clothing and Commerce, the paper size is applicable to the Chinese National Standard (CNS) Λ4 specification (210X 297 mm) } Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs and Industrial Cooperatives, 4228 5 5 A7 ____ B7 V. Description of the Invention (Less) Type bifocal constant lenses usually follow the design of bifocal lenses of conventional glasses. Conversion lenses have two discrete limitations. The viewing area, they have different optical magnifications. When the object system that the wearer wants to see is different from the current focus, the position of the bifocal lens on the eye must be moved from one area to another. A major problem with the known conversion type bifocal ophthalmic lenses is the problem faced by the wearer when attempting to move the position of the lens on the eye. The lens must be moved or migrated over a considerable distance over the eye in order to pass through a field of view Change to another viewing area, and the movement from one viewing area to another must be completed before clear vision can be achieved. Recently, it has been proposed that Active controllable method for bifocal function. An example of a simultaneous visual bifocal lens system partially coated with a thermochromatic coating. Bifocal lens system design when the wearer looks down and focuses on a close object A thermochromatic coating for activating the far optical area of the lens. The activated thermochromatic area of the lens prevents light from passing through the far optical area, thereby preventing the blur or haze of light from near objects. This method is not highly practical Because the currently available thermochromic coatings are not practical enough to activate or deactivate quickly. Another method is to use a lens 'which can be used to change the focal length with the help of a switchable battery or a photovoltaic cell.' It is also impractical because the electronic circuit and power supply must be small enough to be packaged in an ophthalmic invisible eye and must be highly reliable and durable. For ophthalmic lenses that can reliably provide multifocal functions but do not have the disadvantages of prior art multifocal lenses There is still a need. The present invention provides a multifocal lens containing a volume holographic optical element that provides optical magnification. This lens It has more than one kind of optical magnification, and the pre-stretching scale is applicable. China " ^ 5 " quasi (CNS) A4 specification (21〇 > < 297 Gongchu.) — ~ (Please read the precautions on the back before Fill out this page}

4228 5 5 A7 _______B7_ ____ 5. Description of the Invention (Order) (Read the notes on the back of the poem before filling this page) One of the optical magnifications allows the wearer to actively and selectively control in order to see the clear and undamaged image. This lens system is suitable for various optical lenses, including contact lenses, ophthalmic lenses, and intraocular lenses. An embodiment of the present invention provides a multifocal lens having a first optical element and a volume holographic optical element, wherein the first optical element provides a first optical magnification at the first focus, and the holographic optical element or a holographic optical element combined with the first The optical element provides a second optical magnification at a second focus. Another embodiment provides a multifocal lens having a volume holographic optical element, wherein the holographic optical element has a stylized activation angle, and the optical element provides a first optical magnification, such as a correction magnification or a plane, for use outside of the activation angle. For light rays entering the optical element at an angle, and providing a second optical magnification 'for light rays entering the optical element at an angle within the activation angle. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs The present invention also provides a method for correcting visual defects. This method has the steps of providing a multifocal lens on the eye and moving the multifocal lens on the eye so that the proper focus is placed on the center of the retina of the eye. The multifocal lens may be characterized in that the multifocal lens has a first optical element and a volume holographic optical element, wherein the first optical element provides a first optical magnification at the first focus, and the holographic optical element or a holographic optical element combined with the first optical element The element provides a second optical magnification at a second focus. As another embodiment of the present invention, the multi-focal lens may be characterized in that the multi-focal lens has a holographic optical element having a stylized activation angle, wherein the optical element provides a first optical magnification for use outside of the activation angle. For light rays entering the optical element at an angle, and providing a second optical magnification for light rays entering the optical element at an angle within the activation angle. ______5___ & Zhang scales are applicable to Chinese National Standard (CNS) A4 specifications (2Ϊ0 × 297 mm) 4228 55 A7 _____B7_ 5. Description of the invention (+) The multifocal lens of the present invention is a highly effective corrective lens, which does not have a simultaneous vision lens And the disadvantages of the conventional conversion lens. The present invention provides a biocompatible holographic element made from a crosslinkable or polymerizable prepolymer. The prepolymers are selected from crosslinkable or polymerizable optical materials, and they can form a non-fluid or solid biocompatible optical element within five minutes of UV light source irradiation. By placing the prepolymer between the bottom and top quartz slides and providing a UV light source to measure the duration of cross-linking or polymerization, the UV light source is a 200 watt medium pressure mercury arc lamp and placed on the top quartz slide 18 cm above. The biocompatible holographic element is preferably a transmissive volume holographic element. The invention also provides a hydrogel holographic element, which is made of a prepolymer. Also provided is a method of making a holographic element from a fluid composition of a prepolymer or monomer. The holographic element can be used as a medical device, for example, as an optical lens and an ophthalmic lens. The optical and ophthalmic lenses having the holographic optical element of the present invention are relatively easy to manufacture and highly suitable for correcting various refractive abnormalities. FIG. 1 illustrates an active ophthalmic lens of the present invention. Fig. 2 illustrates the diffraction function of the holographic optical element of the active lens of the present invention. FIG. 3 illustrates an active ophthalmic lens of the present invention. Figure 4 illustrates the transmission function of a holographic optical element. Figure 5 illustrates the diffraction function of a holographic optical element when the element is activated. FIG. 6 illustrates an exemplary method of manufacturing a holographic optical element. Figure 7 illustrates the optical magnification of a holographic optical element. 8-8B illustrate a combined holographic optical element of the present invention. ---- 6_____ The paper size applies the Chinese National Standard (CNS) Λ4 specification (210X297 mm) -----— (Please read the precautions on the back before filling this page) 7 Order the staff of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Consumer Cooperative 4228 5 5 A7 ___________B7 V. Description of the Invention (<)-Figure 9 illustrates the spectacle composite lens of the present invention. The present invention provides an active multifocal ophthalmic lens. The present invention also provides an active multifocal lens for spectacles. In terms of · y, unless otherwise referred to the sun and the moon, the term, optical lens is used for ophthalmic lenses and ophthalmic lenses. The active optical lens of the present invention provides more than one optical magnification. More specifically, the lens provides at least one optical magnification and at least one additional optical magnification (which can be activated). Unlike the conventional bifocal lens, the active multifocal lens of the present invention can be actively and selectively controlled so as to provide the desired optical magnification at a time without or substantially no other optical magnification from the lens. interference. The active optical lens contains a holographic optical element (ΗΟΕ) and is suitable for the HOE transmission volume HOE of the active optical lens. The volume HOE contains a dry fringe pattern 'which is programmed or recorded as a periodic change in the refractive index of the optical material. The periodic change of the refractive index produces the plane of the peak chirp index, which is the volume grating structure. The plane of the interference fringe pattern in HOE is discussed further below.

Referring to FIG. 1, this figure illustrates an exemplary active bifocal lens of the present invention. It is noted that for the purpose of illustration, the present invention disclosed herein refers to a bifocal lens, but the active optical lens of the present invention may have more than two Optical magnification. The lens 10 is a contact lens having a first optical element 12 and a HOE 14. The H0E 14 is buried or encapsulated in the first optical element 12 to form the compound lens 10, so that the EOM and the lens 10 move together. The first optical element 12 provides a first optical magnification which corrects a refractive error such as myopia. Alternatively, the first optical element 12 may be a flat lens, and functions as a carrier of the HOE 14. Regarding HOE ----— 7_____ This paper size applies the Chinese National Standard (CNS) Λ4 specification (210X297 mm) (Please read the precautions on the back before filling this page) Order printed by the Intellectual Property Bureau of the Ministry of Economic Affairs Consumer Cooperatives 4228 5 5 A7 _B7_ 5. Description of the invention (k) (Please read the precautions on the back before filling out this page) 14. In terms of optical elements, they are designed to adjust the path of light. This only works when the light is at a pre-programmed angle or When entering the HOE 14 within the range of pre-programmed angles, it is the active corner printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs that activates the optical components. Therefore, when the light enters at an angle other than the activation angle, the HOE 14 completely or substantially completely transmits the light 'without significantly changing or changing the path of the light. In addition, HOE I4 can also be used as a flat lens. The exception is when the incident angle of the incident light comes within the activation angle programmed in advance. When HOE 14 is activated, the stylized stripe pattern or volume grating structure in HOE 14 will change the path of light, providing an optical magnification different from the first optical magnification of the lens. In addition to the optical magnification that can be activated, HOE 14 can also provide an optical magnification generated by the shape of HOE 14 and the refractive index of the composition of HOE 14, when the incident light enters the lens 10 at an angle that does not activate HOE 14, The additional optical magnification supplements the first optical material to provide the first optical magnification of the active lens 10. The term "activation angle" here is used to refer to the incident angle of incident light, which is an angle formed between the forward direction of incident light and an axis perpendicular to the surface of the HOE, which satisfies the Bragg condition The chirped incident light is diffracted by the interference fringe grating structure of the HOE, which will be discussed further below. It is noted that the activation angle is not necessarily a single chirp but can be a range of angles. In the coupled-wave theory of thick holographic gratings defined in H. Kogelnik: Bell System Science and Technology Magazine, Vol. 48, No. 9, pp. 2909-2947 (Nov. 1969, explanation of the Bragg condition disclosed therein 倂This article is for reference. The Bragg condition is as follows: This paper size is applicable to the Chinese National Standard (CNS) A4 specification (21〇 × ^ 97 mm) ~ 4228 5 5 A7 —_____ B7_ V. Description of the invention (1) COS (φ -θ) = ^ / 2B where / Γ = 2π / Λ, Λ = grating period of the dry fringe, Θ is the incident angle of incident light, Φ is the tilt angle of the grating, and B is the average propagation constant, which is expressed by B = 2πη / λ means that η is the average refractive index and λ is the average wave of light When meeting the Bargg condition, it can coherently diffract up to 100% of incident light. Figure 2 further illustrates the function of HOE 14 of the bifocal active lens 10 of Figure 1. The Z-axis is orthogonal to the plane of HOE 14 and the incident light The forward direction of R forms the incident angle σ. When the incident light R enters ΗΟΕ14 at an incident angle within the activation angle of HOE 14, the light R is a pre-programmed dry stripe pattern--that is, the volume grating of HOE 14. Structure-The diffraction and when the light S is made to leave HOE 14 at an exit angle p, the exit angle p is different from the incident angle σ. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs (please read the precautions on the back before filling in this (Page) Fig. 3 illustrates another embodiment of the active bifocal lens of the present invention. The bifocal active lens 16 is a compound lens having a first optical lens 17 and a OE lens 18 which completely covers the first optical lens 17. Another Alternatively, the size of the OE lens 18 may cover only the pupils of the eyes. The first optical lens 17 and the OE lens I8 may be manufactured separately and then bonded, such as by adhesion or heating. In addition, they may be sequentially or simultaneously The first optical lens Π and Η0Ε lens 18 are fabricated so that one is on top of the other to make a compound lens. When the first optical lens and Η0Ε lens are made of one basic material or two chemically compatible materials, the The sequential or simultaneous method is particularly suitable. Although the active lens 16 shown has an inner half of the first optical lens and an outer half of the 0OE lens, other optical components can be manufactured according to the invention) A4 ^ fg. {210X297 ^) ~ ~ A228 5 5 A7 _______B7 V. Description of Invention (Name) Combination. Another embodiment of the active bifocal lens is a non-composite active HOE bifocal lens. In this embodiment, an active HOE bifocal active lens is manufactured from an optical material for forming the h0E. The combination of the shape of the active lens and the refractive index of the HOE material provides a first optical magnification, while the volume grating structure programmed in the HOE lens provides a second optical magnification. This non-composite active HOE lens embodiment is particularly suitable when the HOE material used is a biocompatible material and therefore does not adversely affect the eyeball tissue in the eye. As used herein, the term "biocompatible material" is a polymeric material that has no appreciable deterioration and does not cause a significant immune response or damage to the tissue, such as a toxic reaction or a significant stimulus (when implanted in a patient Within or near biological tissue). Preferably at least six months, more preferably at least one year, and most preferably at least ten years ' The biocompatible material does not deteriorate and does not cause an immune response or a response that damages the tissue. Suitable biocompatible optical materials are highly photocrosslinkable or photopolymerizable optical materials. Suitable biocompatible materials include polyvinyl alcohol, polyethyleneimine, or derivatives and copolymers of polyvinylamine. Biocompatible materials particularly suitable for manufacturing the HOE of the present invention are disclosed in Miiller's U.S. Patent No. 5,508,317 and Mtthlebach's International Patent Application No. PCT / EP96 / 00246, which patents and patent applications Cases are incorporated herein by reference and are discussed further below. The HOE of the present invention is designed or programmed to have an activation angle or an activation angle range that activates the HOE, and the HOE diffracts incident light to focus the light to a desired location. Figures 4 and 5 illustrate the compound active lens 20 ..... J.0 This paper size applies the Chinese National Standard CNS) A4 specification ( ---- 1 (Please read the precautions on the back before filling out this page)-Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, printed by A228 5 5 A7 V. Description of the invention (谙 Read the precautions on the back before filling in this Page} Order the function of HOE 21 printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. The lens contains a programmed HOE lens to focus light from a short distance. When light from a long distance 22 does not activate HOE When the angle of 21 enters the lens, according to the optical magnification of the first optical element 23 of the lens 10 and the optical magnification of the eyeball lens (not shown), the light 20 is focused on the focal point 24 on the retina of the eye, more specifically Is attached to the center of the retina. For example, the first optical element 23 may have a correction magnification ranging between + 10 diopters and -20 diopters. It is noted that the HOE lens 21 may have a shape and a HOE composition from the HOE lens 21 The natural optical power of the refractive index of an object. The HOE lens 21 can contribute to the refractive optical magnification of the active lens 20. However, in the following, the inherent optical magnification of the HOE lens 21 will be ignored, and the description of the diffraction function of the HOE lens of the present invention will be simplified because it is easy to set Intrinsic optical magnification is incorporated into the teachings of the present invention. When the HOE lens 21 is not activated, the HOE lens 21 does not interfere with the light rays 22 that travel through the orthogonal refraction path caused by the first optical lens element 23. However, When the light enters the HOE lens 21 at an angle that will activate the HOE lens 21 (that is, it enters within the activation angle), the light is diffracted by the HOE lens 21. As shown in FIG. 5, when the incident light activates the HOE at a moment When the angle of the lens 26 enters the active lens 25, combined with the first optical lens 27 and the eyeball lens, the lens focuses the light on the retina, more specifically on the center of the retina. For example, when the light is within the stylized activation angle, When the angle enters the HOE lens%, the light 28 originating from the near object 29 forms an image 30 on the center of the retina. The incident light of the active bifocal lens can be changed in different ways. The size of the paper is in accordance with the Chinese National Standard (CNS) A4 (210 X 297 gong). Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, SC Industrial Consumer Cooperative, 4228 5 5 A7 ____B7_ V. Description of Invention (VD) Shooting angle more specifically It is the HOE part of the active lens. For example, the active lens is given the title of changing the incident angle of the incident light, that is, the lens holder can change the incident angle of the light when holding the head position and looking down. Alternatively, the active lens may It has a position control mechanism that can be actively controlled by one or more muscles of the eye of the wearer. For example, the shape of the active lens may have a prim ballast, and the movement of the lens can be controlled with the lower eyelid. It is noted that the activation angle of the active lens 25 is exaggeratedly shown in FIG. 5 in order to explain the present invention more easily, and therefore the activation angle of the active lens is not as large as the tilt angle shown in FIG. 5. Actually, the HOE suitable for the present invention can be programmed in accordance with the HOE programming method known in the holographic art so as to have a wide range of activation angles. Therefore, the movement of the active lens from one optical magnification to another optical magnification can be easily changed, depending on the design basis and the needs of each lens wearer. Although the active lens of the present invention provides more than one optical magnification, the active lens is focused by an optical magnification at a time to form a clear and visible image. Therefore, unlike the conventional bifocal lens, which is like a simultaneous bifocal lens, the active lens does not produce a blurred or foggy image. Returning to FIG. 5, when the active lens 25 is positioned for visually viewing the near object 29 (that is, the incident angle of the light originating from the object 29 is within the activation angle of the HOE lens 26), the light of the object 29 is combined by the HOE lens 26 and combined. The first optical lens 27 and the eyeball lens are focused on the center 30 of the retina. At the same time, the incident angle of the light originating from a distant object is not within the activation angle of the active lens 25. Therefore, the incident light path of the distant object is not changed by the HOE lens 26, but the incident light path of the distant object is changed by the first optical lens 27 and the eyeball crystalline lens, that is, refraction. This paper size applies to China National Standard (CNS) 8-4 specifications (2 丨 OX297 mm) I _ "-yi II (please read the precautions on the back before filling out this page), ^ printed by the Employees' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Control 4228 5 5 A7 _____B7_ V. Description of the Invention (U) The incident light of a distant object is thus focused in an area 31 outside the center of the retina to form an image. Therefore, the focused images of near and far objects are not concentric or axially aligned. It has been found that the image formed outside the center of the retina 31 cannot be clearly seen by the wearer of the active lens and is easily overlooked as peripheral vision. Therefore, the wearer of the active lens 25 can easily see the near object 29 without being disturbed by the light from the distant object. Similarly, when the active lens is positioned to look at a distant object, for example, as shown in FIG. 4, the ray 22 of the distant object enters the lens at an angle outside the activation angle of the HOE 21. Therefore, the path of the light is not affected by the HOE 21 but only by the first optical element 23 and the eyeball lens, thereby forming a distant object image on or near the center 24 of the retina. At the same time, light from nearby objects is diffracted and focused by HOE 21 and is projected onto the area outside the center of the retina. Therefore, the wearer of the active lens clearly sees distant objects without noticeable interference. The non-blur advantage of the active lens of the present invention is the result of the design of the active lens, which utilizes the inherent anatomy of the eye. Retinal receptor concentration outside the central retina is known to be much lower in the central retina. Therefore, you cannot clearly see any image that is focused outside the center of the retina. Because the image is sampled under the retina, it is easy to be ignored by the mind of the mirror user as a peripheral image or image. In fact, it has been found that the visual acuity of the human eye is reduced to about 20/100 for an object system that is only 8 ° from the line of sight. In the active control method described above, the active lens of the present invention provides clear images at an optical magnification using the inherent anatomy of the glasses at a time. Utilizing the anatomy of the eye's inherent retinal receptors and the ability to program different ranges of activation angles in the HOE lens ----- & Zhang scales apply Chinese National Standard (CNS) A4 specifications (2i0x297 mm ) (Please read the notes on the back before filling in this page)

Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4228 5 5 A7 _______B7 V. Description of the Invention (t >) ‘The active lens of the present invention uniquely and selectively provides clear images of objects located at different distances. In contrast to various simultaneous bifocal lenses, active lenses provide unobstructed clear images, and in contrast to conversion bifocal lenses. Active lenses can be easily designed to selectively provide images at different distances with only small movements of the lens . HOEs suitable for the present invention can be made, for example, from polymerizable or crosslinkable optical materials, especially fluid optical materials. Suitable polymerizable materials and crosslinkable HOE materials are discussed further below. For the purposes of the description below, unless otherwise specified, the term polymerizable material is used to refer to both polymerizable materials and crosslinkable materials. FIG. 6 illustrates an exemplary method of manufacturing the HOE of the present invention. The point source light 32 is simultaneously projected on the photopolymerizable optical material 33 (ie, the photopolymerizable HOE), and the parallel reference light 34 is simultaneously projected on the photopolymerizable HOE 33, the object light 32, and the reference light 34. The electromagnetic wave forms an interference fringe pattern, which is recorded in the polymerizable material when the polymerizable material is polymerized, thereby forming a volume grating structure in the lens 33. The photopolymerizable HOE 33 is a photopolymerizable material that is polymerized with an object photo and a reference photo. It is preferred to use a beam splitter to generate object light and reference light from a light source. The split part of the light is directed to the HOE 33, in which the path of the divided objective light part is changed to form the point source light 32. For example, if the conventional optical convex lens is placed at a certain distance from the light polymerizable HOE 33, and the chirped light is focused at a suitable distance from the HOE 33, that is, at the point source light position 32, a point source object can be provided Light 32. The better light source is a laser light source, and the better light source is a UV laser light source. Although the suitable light source wavelength depends on the type of HOE used, the preferred wavelength range is between 300nm and 600nm. When this paper size is in accordance with Chinese National Standard (CNS) A4 specification (210X297 mm) (Please read the precautions on the back before filling this page)

4228 5 5 Α7 Β7 Printed by the Intellectual Property Office of the Ministry of Economic Affairs and Economics Fifth, the invention description (Q) When the photopolymerizable HOE 33 is fully exposed and polymerized, the obtained HOE contains a refractive index modulation pattern, that is, a volume grating structure 35. In addition, when fluid polymerizable optical materials are used in the manufacture of HOE, the light source converts the fluid optical materials into non-fluid or solid HOE while forming a volume grating structure. The term " fluid " as used herein refers to a material capable of flowing like a liquid. Referring to FIG. 7, the aggregated HOE 36 has a focal point 38 which corresponds to the position of the source light 32 at the point of FIG. When the opposite side enters the HOE 36 and matches or substantially matches the reverse path of the parallel reference light of Figure 6. Figures 6 and 7 provide an exemplary method of manufacturing a HOE with a positive correction factor. It can be understood that Some modifications of the above HOE manufacturing method can also produce HOE with negative correction magnification. For example, a convergent light source that forms a focus on the other side of the HOE far from the light source can be used instead of point source light to create a negative correction magnification According to the present invention, 'active multifocal lenses with different correction magnifications can be easily and simply made to correct different refractive abnormalities, such as myopia, hyperopia, presbyopia, regular astigmatism or irregular astigmatism and Combination. For example, by changing the distance, position, and / or path of the object light, the correction ratio of the HOE can be changed, and by changing the position of the object light and the reference light, the activation angle of the HOE can be changed. The invention 'can be made from polymerizable and crosslinkable optical materials capable of photopolymerization or photocrosslinking at relatively rapid speeds to make suitable HOEs. Fast polymerizable optical materials allow periodic changes in refractive index to occur within the optical materials, thereby forming A volume grating structure that simultaneously polymerizes optical materials to form a solid optical material. Suitable polymerizable and crosslinkable optical materials are preferably selected from biocompatible optical materials, and suitable optical materials are preferred. The paper size is applicable to China U-house standard (c is called M size (2i0xW7) (Please read the precautions on the back before filling in this page)

4228 5 5 A7 B7 V. Description of the invention (, Chinese) (Please read the precautions on the back before filling out this page) It is selected from diffusive ke compatible optical materials, especially less than 5 minutes 'better equal to 3 minutes' It is difficult to wait for less than 1 minute, preferably equal to or less than 30 seconds, such as between 5 and 10 minutes, and cross-linking or polymerizing to form a kind of optical element with a definition of __1. The duration of the cross-linking or polymerization is determined by placing a crosslinkable or polymerizable optical material between two quartz slides. The quartz slides have the size of a microscope sheet and are separated by a separator. . A sufficient amount of optical material was applied to the first quartz slide to form a droplet having a diameter of about 14 mm, and the first slide was placed on the optical material. In addition, a partition may be used to form a cylindrical space between sliders for optical materials. The optical material between the slides was illuminated by a 200-watt medium-pressure mercury arc lamp, which was placed 18 cm above the top quartz lamp. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

An example of a group of biocompatible polymerizable polymer optical materials suitable for use in the present invention is disclosed in Miiller U.S. Patent No. 5,508,317. A preferred group of polymerizable optical materials, such as those described in U.S. Patent No. 5,50,317, are those having a basic structure of 1,3-diol, in which a certain percentage of 1% of the diol unit has been modified into one 1,3-dioxane, which is a polymerizable but unpolymerized group at the second position. The polymerizable optical material is preferably a polyvinyl alcohol derivative having a weight average molecular weight of at least about 2000

Mw ′ is based on the number of hydroxyl groups of polyvinyl alcohol and includes about 0.5% to about 80% of units of formula I: 16 4228 5 ο A7 B7 V. Description of the invention (ΐ <)

Among them: R is a lower alkylene group having a maximum of 8 carbon atoms, R1 is a hydrogen or a lower alkyl group, and R2 is an olefinic unsaturated, electron-drawing, copolymerizable group, preferably having a maximum of 25 carbon atoms. R2 is, for example, an olefin-based unsaturated fluorene group of the chemical formula R3-CO-, which is printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs (please read the notes on the back before filling this page) It has 2 to 24 carbon atoms, preferably 2 to 8 carbon atoms, and particularly preferably 2 to 4 carbon atoms. Examples of the olefin-based unsaturated copolymerizable group include vinyl, 2-propenyl, 3-propenyl, 2-butenyl, hexenyl, octenyl, and decenyl. As a suitable embodiment, the group R2 is a chemical formula of the group [-C0-NH- (R4-NH-C0-0) q-R5-0] p-C0-R3 (II) where p is zero or one, which is more than Good zero; __17 This paper size applies to Chinese National Standard (CNS) A4 (21〇χϋmm) — 4228 5 5 A7 B7 5. Description of the invention (4) q is zero or one, preferably zero; R4 and R5 each Independently is a lower alkylene group having 2 to 8 carbon atoms, an arylene group having 6 to 12 carbon atoms, a saturated divalent cycloaliphatic group having 6 to 10 carbon atoms, having 7 to 14 carbons An atomic aralkylene or alkylene arylene 'or an arylene aralkylene having 13 to 16 carbon atoms; and R3 is as defined above. The lower-order phenylene radical R preferably has a maximum of 8 carbon atoms and may be linear or branched. Suitable examples include octyl, hexyl, pentyl, butyl, propyl, ethyl, methylene, 2-butyl, 2-butyl, and 3-pentyl. The preferred low-end Nobuchi R system has a maximum of 6 carbon atoms' and particularly preferably a maximum of 4 carbon atoms. Methylene and butylene are particularly preferred. R1 is preferably hydrogen or a lower alkyl group of up to 7 carbon atoms, especially up to four carbon atoms, especially hydrogen. In the case of R4 and R5, the lower alkylene R4 or R5 preferably has 2 to 6 carbon atoms and is especially straight-chain. Suitable examples include butylene, butylene, hexyl, dimethyl and ethyl, and particularly preferably ethyl. The arylene R4 or R5 is preferably phenylene, which is unsubstituted or substituted with lower alkyl or lower alkoxy, especially 1,3-phenylene or 1,4-phenylene or methyl. 1,4-phenylene. The saturated divalent cycloaliphatic group R4 or R5 is preferably a cyclohexyl group or a cyclohexyl·lower alkylene group, such as a cyclohexylmethylene group, which is unsubstituted or substituted with one or more methyl groups, For example, trimethylcyclohexylmethylene, such as divalent isophorone. The alkylene unit of the alkylene alkylene group or the alkylene group R4 or R5 is preferably an alkylene group, which is unsubstituted or substituted with a lower alkyl group (please read the precautions on the back before filling this page)-Order Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs

N Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, M Industrial Consumer Cooperative, ΛZ8 8 ο A7 B7 V. Description of the invention (\ Ί) or lower alkoxy group, and the alkylene unit is preferably a lower alkylene group, such as methylene Radical or ethylidene, especially methylene. The group R4 or R5 is therefore preferably a phenylene methylene group or a methylene phenylene group. The arylene arylene aryl R4 or R5 is preferably arylene · lower arylene-arylene, which has a maximum of 4 carbon atoms' in the arylene unit, such as arylene arylene. The radicals R4 and R5 are each independently preferably a lower alkylene group having 2 to 6 carbon atoms, a phenylene group, which is unsubstituted or substituted with a lower alkyl group, a cyclohexyl group or a cyclohexyl-lower alkylene group It is unsubstituted or substituted with lower alkyl, phenylene-lower alkylene, lower alkylene-phenylene or phenylene-lower alkylene-phenylene. To produce polymerizable optical materials of chemical formula I, for example, by reacting polyvinyl alcohol with compound II, where r, R1, and R2 are as defined above, and R 'and R "are each independently hydrogen, lower alkyl, or lower alkyl Fluorenyl 'such as ethenyl or propionyl. It is preferably about 0.5 to about 80%, more preferably about 1 to about 50%, and most preferably about 2 to about 15% of the hydroxyl group compound of the polymerizable optical material obtained. Replaced by II. The polyvinyl alcohol suitable for the derived polyvinyl alcohol of the present invention has a weight average molecular weight between about 2,000 and about 1,000,000, preferably between 10,000 and 300,000, and more preferably Between 10,000 and 100,000 _ _ 19 This paper scale is applicable to the Chinese National Standard (CNS) Α < 4 specification (210 × 297 mm) (Please read the precautions on the back before filling out this page) '? Τ 4228 5 5 A7 5 Description of the invention (P), and preferably 10,000 and 50,000. Polyvinyl alcohol has less than about 50%, preferably less than about 20% of unhydrolyzed ethylene acetate units. In addition, polyvinyl alcohol may contain up to about 20 %, Preferably up to about 5% of one or more copolymer units, such as ethylene, propylene, Enamidine, methacrylamide, dimethylacrylamide, hydroxyethyl methacrylate, methyl methacrylate, methyl acrylate, ethyl acrylate, vinylpyrrolidone, hydroxyethyl acrylate, Allyl alcohol and styrene. Polyvinyl alcohol derivatives are polymerized in a solvent by UV cross-linking methods, such as UV laser, to make HOE. Suitable solvents are any solvents that can dissolve polyvinyl alcohol and vinyl comonomer. Examples of solvents include water, ethanol, methanol, propanol, dimethylformamide, dimethylboron, and mixtures thereof. In order to promote the photocrosslinking polymerization process, a photoinitiator that can initiate free radical crosslinking is suitably added. Examples of photoinitiators suitable for use in the present invention include benzoin methyl ether, 1-acylcyclohexylphenyl ketone, Durocure® 1173, and Irgacure® photoinitiator. It is preferably used in total polymerizable formulations. Based on weight, about 0.3 to about 2.0% of the photoinitiator. According to the present invention, the concentration of polyvinyl alcohol in the solvent suitable for manufacturing HOE is preferably between about 3 and about 90% by weight, and more preferably Between about and about 'best between about 10% About 50%, especially when the HOE is designed as an ophthalmic lens. Another group of examples of biocompatible polymerizable optical materials suitable for the present invention is disclosed in U.S. Patent Application Serial No. 08 / 875,340 (Miihlebach's International Patent Application No. PCT / EP96 / 0〇246). The description of polymerizable optical materials in this U.S. patent is incorporated herein by reference. Suitable optical materials include polymer containing _20_ Standard (CNS) A4 Specification (210X297 mm > — (Please read the precautions on the back before filling out this page) Order Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, Printed by the Consumer Cooperatives of the Ministry of Economic Affairs Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economics 4226 5 5 A7 B7 V. Description of the invention (0) Vinyl alcohol, polyethyleneimine, or a derivative of a nitrogen-containing heterolactone component of polyvinylamine, which is based on the number of hydroxyl groups in polyvinyl alcohol or polyethyleneimine or polyethylene, respectively. Contains from about 0.5 to about 80% of the chemical formula IV and V units based on the number of imine or amine groups in the amine: —ch2-ch2— \ 〇 (IV)

V

I R 「C—R2

O R II 丨 3 NH—C—C = CH2 --CH—CH2_N --- c = o R—C—R2 ⑺

0 R II I3 NH—C—C = CH2 where 1 ^ and R2 are independently hydrogen, CrC8 alkyl, aryl, or cyclohexyl, where these groups are unsubstituted or substituted; r3 is hydrogen or CrC8 alkyl, It is preferably a methyl group; and R4 is a -0- or -NH- bridge, and is more preferably -0-. Polyvinyl alcohol, polyethyleneimine and polyvinylamines suitable for the present invention have a number average molecular weight between about 2,000 and 1,000} 000, preferably between 10,000 and 300,000, more preferably between 10,000 and 100,000 21 This paper size applies to Chinese National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before filling this page)

4228 5 5 A7 B7 V. Description of the invention (ii), and the best is 10,000 and 50,000. A particularly suitable polymerizable optical material is a water-soluble derivative of polyvinyl alcohol, which has a range of about 0.5 to about 80 ° based on the number of hydroxyl groups in the polyvinyl alcohol. Between, preferably between about 1 and about 25%, and more preferably between about 1.5 and about 12%, wherein Reu 2 is methyl, R3 is hydrogen, and R4 is -0.0 chain). Polymerizable optical materials of chemical formula IV and V can be prepared, for example, azalactone of chemical formula VI // I—C—R_ (VI) (Please read the precautions on the back before filling this page) Ο— —C- Consumption cooperation between employees of the Intellectual Property Bureau of the Ministry of Economic Affairs (where Ri, R2 and R3 are as defined above) and polyvinyl alcohol, polyethyleneimine or polyvinylamine at high temperatures (between about 55 ° C and 75 ° C) in a suitable organic solvent, if necessary, in the presence of a suitable catalyst. Suitable solvents are those that can dissolve the polymer backbone and include aprotic polar solvents such as formamidine, dimethylformamide, trimethylamine hexamethylphosphate, dimethylboron, pyridine, nitromethane, Acetonitrile, nitrobenzene, chlorobenzene, chloroform, and dioxane. Suitable catalysts include tertiary amines, such as triethylamine, and organic tin salts, such as dibutyltin dilaurate. In addition to the azalactone component, the azalactone-containing optical material may also have its hydrophobic and hydrophilic ethylenic comonomer 'depending on the physical properties of the desired polymerized HOE. Examples of suitable hydrophobic comonomers include CVC, 8 alkyl acrylates and methacrylates, c3_Cl 8 alkyl propanamide and methacrylamide, acrylonitrile, methacrylonitrile, ethylene CVCm -22 'The paper size is applicable to China National Standard (CNS) M specification (210X297 mm) 4228 5 5 A7 B7 V. Description of the invention (4) Salt, c ^ -Cuene, styrene, vinyl alkyl ether, C3_Ci2 Perfluoroalkylethylthiocarbonylaminoethyl acrylate and methacrylate, propyleneoxy and methacryloxy · alkylsiloxanes, N-vinylcarbazole, maleic acid, trans Butenedioic acid, Ci_Ci2 alkyl esters decomposing aconitic acid, and the like. Examples of suitable hydrophilic comonomers include hydroxyalkyl acrylates and methacrylates, propylamine, methacrylamide, methoxylated acrylates and methamphenic acid esters, hydroxyalkylfluorene Amine and methacrylamide, N-vinylpyrrole, N-vinylsuccinimide, N-vinylpyrrolidone, vinylpyridine, acrylic acid, methacrylic acid and the like. A photo-crosslinking method, such as UV laser, is used to polymerize a nitrogen-containing lactone optical material in a solvent to produce a HOE. Suitable solvents are any solvents capable of dissolving the polymer backbone of the optical material. Examples of the solvent include the aprotic solvents related to azalactone modification disclosed above, water, ethanol, methanol, propanol, ethylene glycol, glycerol, dimethylformamide, dimethylmethylene And its mixture. To assist the photocrosslinking polymerization process, it is convenient to add a photoinitiator which can initiate free radical crosslinking. Examples of photoinitiators suitable for the present invention include benzoin methyl ether '1-hydroxycyclohexylphenyl ketone, Durocure® ll73 and Irgacure® photoinitiators. It is preferred to use a photoinitiator of about 0.3 to about 2.0% based on the total weight of the polymerizable formulation. According to the present invention, the azalactone-containing optical material in the solvent is suitable for manufacturing HOE concentration, preferably between about 3 and about 90% by weight, and more preferably between about 5% and about 60%. Between about 10% and about 50%, especially when the HOE is designed as an ophthalmic lens. _--_____ 23__ This paper size is applicable to the Chinese National Standard (CNS) A4 (2H) x 297 mm> ^ I · 1 Pack — ( Please read the notes on the back before filling this page) Order MK-L Consumer Cooperation Department of the Intellectual Property Bureau of the Ministry of Economic Affairs 4228 5 5 A7 ___B7 V. Description of the invention (min) Another group of functionalized copolymers of ethylene lactam And at least one additional ethylene monomer, namely a second ethylene monomer. The copolymer is functionalized with a reactive ethylene monomer. The ethylene lactamamine of the present invention is five to seven members of the formula VII.

(VII) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs where Ra is an alkylene bridge having 2 to 8 carbon atoms; Rb is hydrogen, alkyl, aryl, aralkyl, or alkaryl, preferably Hydrogen, lower alkyl with up to 7 carbon atoms, aryl with up to 10 carbon atoms, or aralkyl or alkaryl with up to 14 carbon atoms; and Rc-based hydrogen or with up to 7 carbon atoms Lower alkyl, preferably methyl, ethyl or propyl. Examples of ethylene lactamamines suitable for the present invention include N-ethylene-2-cholpyrrolidone, N-ethylene-2-caprolactam, N-ethylene-3-methyl-2_pyrrolidine Ketone, N-ethylene-3-methyl_2_pyrimidone, N-ethylene-3-methyl_2 · caprolactam, N-ethylene-4-methyl-2-pyrrolidone, N- Ethylene-4-methyl-2-caprolactam, N-ethylene-5-methyl-2-¾pyridone, N · ethylene_5_methyl_2_piperidone, N-ethylene-5 , 5-dimethyl-2-pyrrolidone, N-ethylene-3,3,5-trimethyl-2-pyrrolidone, N-ethylene-5-methyl-5-ethyl-2-pyrrole Pyridinone, N-ethylene-3,4,5 · trimethyl-3-ethyl-2-pyrrolidone, N-ethylene-6-methyl-2-meridone, N-ethylene-6-ethyl N-methyl-2-naphthyridone, N · ethylene_3,5-dimethyl-2-tonidone, N-24 (Please read the precautions on the back before filling this page) Outfitting ·-Binding · Paper The standard is applicable to the Chinese National Standard (CNS) Λ4 specification (21〇 × 297 mm) 4228 5 5 A7 _B7 _ V. Description of the invention (> Order) Ethylene_4,4_dimethyl-2-piperidone, N- Ethylene-7-methyl-2-caprolactam, N-ethylene-7-ethyl-2-caprolactam, N-ethylene G, 5-dimethyl-2-caprolactam, isobutylene -4,6- Methyl-2-caprolactam,: ^ - vinyl-3,5,7-trimethyl-2-caprolactam and mixtures thereof. The preferred ethylene lactamamine is a heterocyclic monomer of formula VII, which contains 4 to 6 carbon atoms in the heterocyclic ring. More preferred ethylene limidine has a heterocyclic monomer of formula VII, wherein the heterocyclic ring has 4 carbon atoms and Rb and R are independently selected from hydrogen and lower alkyl components. A highly suitable vinylideneamine is N-ethylene-2-pyrrolidone. Suitable second ethylene monomers include ethylene monomers which, in addition to having a vinyl group, have a functional group such as a hydroxyl group, an amine group, a lower alkyl-substituted amino group, a carboxyl group, an esterified carboxyl group, an alkoxycarbonyl group, Oxy or sulfo (-S03H). When the vinyl group of the second ethylene monomer reacts with ethylene lactam to produce a polymer chain, the functional groups remain and can be used to modify or functionalize the polymer. Suitable functional vinyl monomers include hydroxy-substituted lower acrylic and alkyl methacrylates, ethoxylated acrylic and alkyl methacrylates, epoxy-lower acrylic and alkyl methacrylates, epoxy-cycloalkyl-low Methacrylic acid and alkyl methacrylates, hydroxy-substituted lower alkylacrylamides and methacrylamides, hydroxy-substituted lower alkyl vinyl ethers, amino- or hydroxy-substituted styrenes, sodium ethylenesulfonate , Sodium styrene sulfonate, 2-propenylamino 4-methylpropanesulfonic acid, acrylic acid, methacrylic acid, amine-lower alkyl and alkylamino-lower acrylic acid and alkyl methacrylate, propyleneoxy- And methacryloxy-lower alkylmaleimide and allyl alcohol. The term "lower alkyl" as used herein refers to an alkyl group of up to 7 carbon atoms, preferably up to 4 ___— _ 25 Yi Zhang Dadu applies the Chinese National Standard (CNS) Λ4 specification (210X297 mm) _ (Please read the precautions on the back before filling out this page) Γ Install ·, -a Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy ms 3 〇 A7 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy f) carbon atoms. Particularly suitable functional vinyl monomers include 2-hydroxymethyl dienoate, 3-hydroxypropyl methacrylate, acrylic acid, methacrylic acid, 4-aminostyrene, 3 -Methacryloxymethyl-7-oxa-bicyclofluorene · 1.0] heptane, N-methacryloxyethyl-maleimide, glycidyl methacrylate, ethylformyl Copolymers of ammonium methacrylate hydrochloride and propyl methyl methacrylate ammonium hydrochloride I OL · Copolymers of ethylene lactam and a second ethylene monomer are produced in a known manner with or without solvents. Copolymers can also be statistical Polymer ° Statistical polymers are prepared, for example, in U.S. Patent No. 5,712,356. Suitable solvents would be Hydrolyzes monomers and polymers made from monomers and is substantially inert to the monomers and polymers. Examples of suitable solvents include: water; alcohols such as methanol, ethanol, and propanol; carboxylic acid Amines, such as dimethylformamide and dimethylarylene; ethers, such as diethyl ether, THF, and diethylene glycol dimethyl ether; and mixtures thereof. Suitable compositions have a weight average molecular weight between about 2,000 and 1, Between 000,000, preferably between 10,000 and 300,000, more preferably between 10,000 and 100,000, and optimally between 10,000 and 50,000 ° The copolymer is modified with a reactive ethylene monomer to make a fast crosslinkable Polymer. Suitable reactive vinyl monomers have a reactive component in addition to the vinyl group, which reacts with functional groups present in the copolymer to form covalent bonds while retaining the vinyl group of the monomer. Suitable reactivity Examples of ethylene monomers include hydroxy-substituted lower alkyl acrylates and methacrylates, hydroxy-substituted lower alkyl allylamines and methacrylamides, hydroxy-substituted lower alkyl vinyl ethers, 2-propylene fluorene 2-methyl propane sulfonic acid _________26 Min Zhang scale applicable Chinese National Standard (CNS) Α4 size (210X297 mm) - " (please read the Notes on the back of the House and then fill in this page) is called wear, - '

J 4226 5 5 A7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (/), Amine-lower alkyl and mono-lower alkylamino-lower alkyl acrylate and methacrylate, allyl Alcohols, epoxy-lower alkyl acrylates and methacrylates, isocyano-lower alkyl acrylates and methacrylates, ethylenically unsaturated carboxylic acids having 3 to 7 carbon atoms, and halogens And its anhydrides, amine-, hydroxy- or isocyanate-substituted styrenes, and epoxy-cycloalkyl-lower alkyl acrylates and methacrylates. Preferred reactive ethylene monomers include hydroxyethyl acrylate and methacrylate, hydroxypropyl acrylate and methacrylate 'isocyanatoethyl acrylate and methacrylate, acrylate and methyl Acrylate chloride, ammonium ethyl methacrylate hydrochloride, and propyl ammonium methacrylate hydrochloride. Functionalized copolymers are typically crosslinked and polymerized using a photocrosslinking method-such as with UV laser-in a solvent to make HOE ', but the copolymer can be crosslinked and polymerized in the absence of a solvent. Suitable solvents are any solvents capable of dissolving the polymer backbone of the polymer. Examples of the solvent include water; alcohols such as methanol and ethanol; carboxamides such as dimethylformamide and dimethylboronite; and mixtures thereof. Examples of photoinitiators suitable for use in the present invention include benzoin methyl ether, 1-acylcyclohexylphenyl ketone, Durocure® 1173 and Irgacure® 2959. It is preferred to use from about 0.3 to about 2.0% of the total weight of the polymerizable formulation. According to the present invention, the concentration of the functionalized ethylene linamine copolymer alcohol in the solvent (which is suitable for manufacturing HOE) is preferably between about 3 and about 90% by weight, more preferably between about 5% and about 60%. Between 10% and 50%, especially when the HOE is designed as an ophthalmic lens. It can be made by the traditional recording medium of other volume transmission holographic optical elements __27____ (Please read the precautions on the back first) (Fill in this page again)-Binding

X & Zhang scale applies Chinese National Standard (CNS) A4 specification (210X297 mm) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 42 ^ 8 5 5 A7 _____B7 V. Description of the invention (1) Suitable for the present invention Another group of HOE. Like the polymerizable material for HOE described above, the first light and the parallel reference light are simultaneously projected on the HOE recording medium. The electromagnetic waves of the object light and the reference light form an interference fringe pattern. The interference fringe pattern ', that is, the volume grating pattern, is recorded on the HOE medium. When the HOE recording medium is completely exposed, the recorded HOE is developed in accordance with a known HOE developing method. Suitable volume transmission holographic optical element recording media include commercially available holographic recording materials or plates, such as two-color gelatin. Holographic recording media are available from many manufacturers, including Polaroid Corporation. Other holographic media suitable for the present invention are disclosed, for example, in Polaroid's International Patent Application No. PCT / US96 / 15600 and Nippon Paint's U.S. Patent No. 5,453,340. When photographic recording materials are used as HOE, the toxicological effects of the materials on the eye environment must be considered. Therefore, when a conventional photographic HOE material is used, it is preferable to encapsulate the HOE in a biocompatible optical material. Biocompatible optical materials that can be used to encapsulate HOE include optical materials suitable for the first optical element of the active lens of the present invention, and suitable materials will be discussed further below. As is known in the art of ophthalmology, ophthalmic lenses should have a thin size and thickness to increase the comfort of the wearer. Therefore, a thin HOE system is more suitable for the present invention. However, in order to provide HOE with high diffraction efficiency, the HOE must be optically thick, that is, the light is diffracted by more than one interference fringe plane. One way to provide an optically thick and thin HOE is to program the interference fringe pattern 'so that its direction is inclined toward the length of the HOE. The inclined volume grating structure makes the HOE at the incident angle of incident light and J ---.----- 7 of the emitted light-(Please read the precautions on the back before filling this page) Applicable to Chinese national standard (CNS Ui0x: m mm) 4228 δ 5 Α7 ___ Β7 V. Description of the invention (>) There is a large angular deviation between the exit angles. However, hoe with large angle deflection may not be particularly suitable for ophthalmic lenses. For example, when such a shoe is used in an ophthalmic lens and HOE is activated, the activated line of sight is clearly bent away from the normal line of sight of the eye. As a preferred embodiment of the present invention, a multi-layer combined HOE, especially a double-layer HOE, is used to determine the angular limitation of the HOE design. FIG. 8 shows an example of the multilayer HOE 40 of the present invention. A two-size thin HOE having a large-angle deviation is made into a combined HOE to provide a thin-size HOE having a small-angle deviation. The combined HOE 40 has a thin first HOE 42 and a thin second HOE 44. The first HOE 42 series program is designed to diffract incident light. When the light enters the HOE at an activation angle α, the outgoing light of Η0E 42 forms an exit angle β, which is greater than the incident angle α, as shown in FIG. 8A. The first 100E preferably has a thickness of about 10 micrometers to about 100 micrometers, more preferably about 20 micrometers to about 90 micrometers', and most preferably about 30 micrometers to about 50 micrometers. The second HOE 44 series is programmed to have an activation incident angle β and an exit angle β of the first HOE 42. In addition, the second HOE 44 series program is designed to focus incident light on a focal point 46 (when the incident light enters within the activation angle β). Figure 8B shows the second HOE 44. The second EOE preferably has a thickness between about 10 microns and about 100 microns', preferably between about 20 microns and about 90 microns, and more preferably between about 30 microns and about 50 microns. When the first HOE 42 is placed beside the second HOE 44 and the incident light is guided at an angle corresponding to the activation angle α of the first HOE 42, the light leaving the multi-layer HOE 40 is focused on the focal point 46. By using a multi-layer combined type ΕΟΕ ', a thin ΗΟΕ having high diffraction efficiency and small angle deviation can be prepared. In addition to the advantages of high diffraction efficiency and small angle deflection, 'using multi-layer type ΗΟΕ ________ 2 ^ ——___ & Zhang scale is applicable to the Chinese national f fS) Α4 specification (210X2W mm) (Please read the precautions on the back before reading (Fill in this page) Binding Printed by Employee Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 4228 5 5 Printed by Intellectual Property Bureau of Ministry of Economic Affairs of Industrial Consumer Consumption Du A7 5. Explanation of the invention (> 3) also provides other additional advantages, including correction of dispersion aberrations And chromatic aberration. A single HOE may produce images with dispersion aberrations and chromatic aberrations' because visible light is composed of electromagnetic wave spectra with different wavelengths and the difference in wavelengths may cause HOE to diffract electromagnetic waves differently. It has been found that a multi-layer type, especially a two-layer type, HOE can offset these aberrations that may be produced by correcting a single-layer HOE. Therefore, the multi-layer combined HOE system is more suitable as the HOE component of the active lens. According to the present invention, the suitable HOE preferably has a diffraction efficiency of at least about 70%, more preferably at least about 80%, and most preferably at least 95%. This is in terms of all or substantially all wavelengths of the visible spectrum. The HOE system, which is particularly suitable for the present invention, has a diffraction efficiency of 100%, which is the entire wavelength of the visible spectrum. However, HOEs having a lower diffraction efficiency than those specified above are also applicable to the present invention. In addition, the preferred HOE system of the present invention has a sharp transition angle between the activated and inactivated stages without a gentle transition angle. It is possible to achieve the activation or deactivation of the HOE by small movements of the active lens. No or only minimal transitional images are formed during the movement between the inactivation stages. As for the first optical material of the active lens, an optical material suitable for a rigid lens, a breathable lens, or a hydrogel lens may be used. Suitable polymeric materials for the first optical element of an active ophthalmic lens include hydrogel materials, rigid breathable materials, and rigid materials that are known to be used in the manufacture of ophthalmic lenses such as contact lenses. Suitable hydrogel materials typically have a crosslinked hydrophilic network and hold about 35% to about 75% water based on the total weight of the hydrogel material. Examples of suitable hydrogel materials include copolymers, which have methylpropene ______30 scale and are applicable to Chinese National Standards (CNS) Λ4 specifications (2Ϊ ^ 297 mm) --------- (Please read first Note on the back, please fill in this page again.) Equipment,-= 5 4228 5 5 A7 _______B7 V. Description of the invention (> /) Suspicious dihydroxyethyl ester and one or more comonomers such as 2-hydroxy acrylate, Ethyl acrylate, methyl methacrylate, vinylpyrrolidone, N-ethylene acrylamide, hydroxypropyl methacrylate, isobutyl methacrylate, styrene, ethoxyethyl methacrylate, Methoxytriethylene glycol methacrylate, glycidyl methacrylate, acrylamide diacetone, vinyl acetate, acrylamide, trimethyl acrylate, methoxymethyl methacrylate, acrylic acid Acid, methacrylic acid, glyceryl ethacrylate and dimethylaminoethyl acrylate. Other suitable hydrogel materials include copolymers having methyl vinylcarbazole or dimethylaminoethyl methacrylate. Another suitable group of hydrogel materials includes polymerizable materials such as modified polyvinyl alcohol, polyethyleneimine, and polyvinylamine, such as disclosed in Beat Miiller, US Patent No. 5,508,317, and International Patent Application No. PCT / EP96 / 01265. Another group of highly suitable hydrogel materials includes the silicone copolymers disclosed in International Patent Application No. PCT / EP96 / 01265. Suitable rigid breathable materials for the present invention include crosslinked silicone polymers. The polymer network combines suitable cross-linking agents such as Ν, Ν · -dimethylbispropenamide, ethylene glycol diacrylate, trihydroxypropane triacrylate, isopentaerythritol tetraacrylate, and other similar polymers. Functional acrylates or methacrylates, or ethylene compounds, such as Nm, ethylaminodivinoxazole. Suitable rigid materials include acrylates, such as methacrylates, diacrylates and dimethacrylates, pyrrolidone, styrene, amidine, acrylamide, carbonate 'ethylene', acrylonitrile, nitriles, boron And similar. Among these suitable materials, hydrogel materials are particularly suitable for the present invention. According to the present invention, when implementing one of the embodiments of the compound active lens, ________31____ can be applied to the nine national standards (CNS> A4 specification UOX297 mm) ~ (Please read the precautions on the back before filling this page)

T Pack-Ding,-= '* The Intellectual Property Bureau of the Ministry of Economic Affairs praises the printing of consumer cooperatives 42Z8 5 5 The Intellectual Property Bureau of the Ministry of Economic Affairs prints A7 of industrial and consumer cooperatives V. Description of the invention σ) The first optical element and HOE may be laminated The HOE is encapsulated in a first optical element to form an active lens. In addition, when a non-biocompatible HOE is used to manufacture an ophthalmic active lens, the HOE is preferably encapsulated in the first optical element so that the HOE does not directly contact the eye environment, because the HOE may have a long-term adverse effect on corneal health. Alternatively, as discussed above, the active lens may be made from a biocompatible HOE, which may provide the lens' diffraction and refraction functions. FIG. 9 shows another embodiment of the present invention. The bifocal ophthalmic lens 50 is formed by laminating a layer of a first optical material having a first optical magnification 52 (which provides an optical magnification) and a layer of HOE 54 (which provides a second optical magnification). The two layers are made separately and then joined, such as by heating or adhesion. The compound lens can then be machined to match the frame to provide a pair of bifocal glasses. The first optical material 52 is a conventional optical material, which has been used in the manufacture of glasses, such as glass, polycarbonate, polymethyl methacrylate or the like, and H0E is any holographic optical material, which can be programmed For focusing incident light, as previously described. Alternatively, a bifocal ophthalmic lens can be manufactured from a shaped H0E, that is, the optical shape of the H0E provides refractive power when the H0E is not activated and the structure of the H0E provides diffraction power when the H0E is activated. The multifocal optical lens of the present invention can be actively and selectively controlled to provide a desired optical magnification at a time. Unlike the conventional bifocal lens, the multifocal optical lens of the present invention has no or substantially no Optical interference at other optical magnifications. In addition, the programmable nature of the H0E of the active lens makes the lens system highly suitable for correcting refractive abnormalities that are not easily adjusted by conventional corrective optical lenses. For example, by specially designing the object light, | ---.----------- 1Γ ------ γβ Lu Yi (Please read the precautions on the back before filling this page) ___ 32 The consumer cooperation of the Intellectual Property Bureau of the Ministry of Economic Affairs has printed A228 5 5 A7 ________B7_ V. The description of the invention (彳 I) and the configuration of the reference light. The active lens can be programmed so that it has a regular astigmatism state and a distorted corneal curvature. Corrective power. The following examples further illustrate the present invention. However, these examples are not intended to limit the present invention. Examples

Beispiel 1: Example 1 A Nelfikon A lens monomer composition of about 0.06 ml was deposited at the center of a female mold half, and a mating male mold was placed on the female mold half to form a lens mold assembly. to make. The male mold halves do not contact the female mold halves, and they are separated by about 0.1 mm. The lens half-mold is made of quartz and masked by chromium, with the exception of a central circular lens portion with a diameter of about 15 mm. In short, Nelfilcon A is a crosslinkable modified polyvinyl alcohol product containing about 0-48 millimoles / gram of acrylamide crosslinker. Polyvinyl alcohol has an acetate content of about 7.5 mole%. Nelfilcon A has a solids content of about 31% and contains about 0.1% of a photoinitiator, Durocure® 1173. Place the closed lens mold assembly under the laser device. The laser device provides two coherent parallel UV laser beams, which have a wavelength of 351 nm. One of the beams passes through an optical convex lens, and a focal point is formed at 500 nm from the lens mold assembly. The focused light acts as a point source light. The angle between the object light path and the reference light path is about 7 °. The device provides a HOE with a correction magnification that increases by 2 diopters. The lens monomer composition was exposed to a laser beam having about 0.2 watts for about 2 minutes to completely polymerize the composition to form an interference fringe pattern. Because the lens molds other than the central part are masked, the single lens system exposed by the circular central part of the mold is subject to light and reference. ____33___ This paper size is applicable to China National Standard (CNS) A4 (210X297) (Li) J .--- * ----- installation -------- 1T ------ Γ. Please (please read the precautions on the back before writing this page) Λ228 5 5 A7 B7 V. Description of the invention 〇 >) The employees' cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs printed and irradiated with light to aggregate. Open the mold assembly, leaving the lens stuck to the male mold. About 0.06 ml of Nelfilcon A lens monomer composition was again deposited on the center of the female mold half, and the male mold half with the shaped lens was placed on the female mold half. The male and female mold halves are separated by approximately 0.2 mm. The closed lens mold assembly is again exposed to the laser device, with the exception that the optical convex lens is removed by the objective light device. The monomer composition is again exposed to the laser beam for about 2 minutes to completely polymerize the composition. The composite lens obtained has an optical magnification based on the shape of the lens and the refractive index of the lens material, and has a refractive power of +2. Activated additional correction magnification. Beispiel 2: Example 2 110 grams of polyvinyl alcohol (Mowiol ™ 4-88, available from Hoechst AG and having a hydrolysis rate of 87.7% w and a Mw (g / mole) of about 31,000) were dissolved at 90 ° C in 44 grams of deionized water and cooled to 22 ° C. 100.15 g of a 20.6% methylpropylaminoacetaldehyde dimethyl acetal aqueous solution, 38.5 g of concentrated hydrochloric acid (37% p.a. Merck), and 44.7 g of deionized water were added. The mixture was stirred at room temperature for 22 hours and then adjusted to pH 7.0 with a 5% NaOH solution. The solution was diluted to 3 liters with deionized water, filtered, and subjected to ultrafiltration using a 1-KD-Omega membrane made of Filtmn. After repeating three times the sample volume, the solution was concentrated. 660 g of a 17.9% solution of polyvinylalcohol in 1,3-acetal of polyvinyl alcohol having a viscosity of 210 cp was obtained. According to the NMR test, 11 mole% of the OH group has been acetalized, and the air was extracted under reduced pressure to concentrate a 5 mole% acetalized OH group polymer aqueous solution, resulting in a 30.8% viscosity of 30.8 % Solution. The paper size of the paper applies the Chinese National Standard (CNS) A4 specification (2) 0X297 mm (Please read the precautions on the back before filling this page), and call it binding 4228 5 5 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 __B7_ V. Description of the Invention (Based on the polymer content, 0.7% Durocure® 1173 is added to the 30.8% solution. The solution is introduced into a polypropylene transparent contact lens mold. The mold has about 1 〇〇im's central cavity thickness, and closed the mold. The solution was irradiated with a 200-watt Oriel UV lamp from a distance of 18 cm for 6 seconds. The mold was opened and the transparent contact lens was removed. This contact lens is biocompatible It means that the lens will not adversely affect the eye environment when worn for a long time. The modulus and flexible elongation of the lens are 0.9 mPa and 50%. Beispiel 3: Example 3 High quality polyvinyl alcohol. 25 grams of polyvinyl alcohol (Mowiol ™ 4-98, available from Hoechst AG with 98.4% w hydrolysis rate and Mw (g / mole) of about 27,000) was dissolved at 200 ° C at 200 ° C. 100 g of DMSO in a ml round bottom flask The flask was mechanically stirred and under a nitrogen blanket. 0.5 g of catalyst (1,8-diazabicyclo [5.4,0] -undec-7-ene) was added followed by 7.14 g (0_051 mole) of 2 -Ethylene-4,4-dimethylazalactone. The mixture was stirred for a further 24 hours at 65 ° C. The resulting modified polymer was precipitated in 1 liter of acetone under vigorous stirring. The precipitate was filtered and the Dry. The modified polymer has about 9 mole% of polyvinyl alcohol's OH group to react with azalactone. The modified polymer is dissolved in DMSO to provide a about 30% solution, and Irgacure® 2959 is added to make 0.1 % Photoinitiator solution. Approximately 0.6 ml of the modified crosslinkable polymer solution was placed on a quartz slide (which has the size of a microscope slide), and a second quartz slide was placed on the solution. A spacer is used to maintain the gap between the slides at 100mm. The slides are located at the slide __ _____35 & the scale applies the Chinese National Standard (CNS) A4 specification (210X297 mm) " " " n--l ^ i ! _--n I ^ 衣 --- (谙 Please read the notes on the back before filling in this page) • L--Order

J Λ Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4228 5 u Α7 _ V. Description of the Invention (3 buckets) The crosslinkable solution between the tablets has undergone the HOE recording method, as shown in the first recording step of Example 1. Revealer. The obtained HOE has a diffraction efficiency of about 70%. The above examples demonstrate that the polymerizable optical material selected according to the benchmark of the present invention can manufacture holographic optical elements (Η0Ε), especially biocompatible 可 0Ε, which can be used in various applications, including optical lenses, such as multifocal contact lenses . Element symbol description 10 Active bifocal lens 12 First optical element 14 Holographic optical element (H0E) 16 Bifocal active lens 17 First optical lens 18 H0E lens 20 Composite active lens 21 H0E lens 22 Light beam 23 First optical element 24 Focus 25 Active lens 26 H0E lens 27 First optical lens 28 Light 36 This paper size applies to China National Standard (CNS) A4 (210 X 297 cm) ----- If ------- {'衣- ------ l · Order ----------- Line-1 (Please read the notes on the back before filling this page) 4228 5 5 A7 _B7 V. Description of the invention (clothing)

29 Near object 30 Image 31 Area 32 Point source light 33 HOE 34 Reference light 35 Volume grating structure 36 HOE 38 Focus 39 Light 40 Multi-layer combined HOE 42 First HOE 44 Second HOE 46 Focus 50 Bifocal eyeglass lens 52 First Optical material 54 HOE (Please read the notes on the back before filling out this page) Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs Employee Cooperatives 37 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm)

Claims (1)

(228 (228 A8 B8 C8 D8 1. A multifocal optical lens comprising a first optical element and a transmission volume holographic optical element 'wherein the first optical element provides a first optical magnification at a first focus' and the holographic optical element is provided at A second optical magnification of a second focal point, wherein the first and second focal points are not axially aligned. 2. The multifocal optical lens according to item 1 of the patent application scope, wherein the optical lens is an ophthalmic lens and has a stabilization mechanism. 3. For example, the multi-focus optical lens of the scope of patent application, where the holographic optical element diffracts up to 100% of the incident light when the Bragg condition is met. The multifocal optical lens, wherein the first optical magnification is selected from +10 diopters to -20 diopters. 5. The multifocal optical lens according to item 4 of the patent application, wherein the second optical magnification is a positive optical magnification. 6. The multifocal optical lens according to item 1 of the patent application scope, wherein the lens corrects nearsightedness, farsightedness, presbyopia, regular or irregular astigmatism, and combinations thereof. 7. A multifocal optical lens comprising a transmissive volume holographic optical element, the optical element having a stylized activation angle 'wherein the optical element provides a first optical magnification for entering the optical at an angle other than the activation angle The light of the element is used, and a second optical magnification is provided for the light entering the optical element at an angle within the activation angle. 8. The multifocal optical lens according to item 7 of the patent application, wherein the optical lens is an ophthalmic lens and has a stabilization mechanism. 9. If the multi-focus optical lens of item 7 in the scope of the patent application, the size of this paper adopts China National Standard (CNS) A4 specification (2 丨 0 > < 297 mm) < Please read the back Note: Please fill in this page again.) '1T Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 8 8 88 ABCD 4228 5 5 VI. Patent application scope Optical lenses are contact lenses. 10. The multifocal optical lens according to item 7 of the patent application scope, wherein the first optical magnification is selected from +10 dioptre to -20 dioptre. 11. The multifocal optical lens according to item 10 of the application, wherein the second optical magnification is a positive optical magnification. 12. The multifocal optical lens according to item 7 of the patent application, wherein the lens corrects nearsightedness, farsightedness, presbyopia, regular or irregular astigmatism, and combinations thereof. 13. A method of correcting an abnormal refractive state, comprising the steps of: a) providing a multifocal lens on the eye, the multifocal lens including a first optical element and a transmission holographic optical element, wherein the first optical element is provided at A first optical magnification of a first focus, and the holographic optical element or a combination of the holographic optical element and the first optical element provides a second optical magnification of a second focus, and b) moves the multifocal lens on the eye俾 The first focus or the second focus is selectively located on the center of the retina of the eye. 14. The method according to item 13 of the patent application, wherein the optical lens is an ophthalmic lens and has a stabilization mechanism, and the lens can be stably moved from one position to another. Method, where the holographic optical element diffracts up to 100% of incident light when Bragg conditions are met. 16. The method according to item 13 of the scope of patent application, wherein the abnormal refractive state is nearsightedness, farsightedness, presbyopia, regular astigmatism or irregular astigmatism, or a combination thereof. _____2____ This paper is in use ® National Standard (CNS) Α4 size (210X297 mm) (Please read the precautions on the back before filling out this page)-Order 'Ϊ ·! Staff of Intellectual Property Bureau of the Ministry of Economic Affairs Printing A8 B8 C8 D8 Λ2Z3 5 5 6. Application for patent scope 17. The method of applying for patent scope item 16, wherein the abnormal refractive state is presbyopia state and the first optical magnification is selected from +10 diopter to diopter . 18. A method for providing multi-focal vision correction, comprising the steps of: a) providing a multi-focal lens on glasses, the multi-focal lens including a holographic optical element having a stylized activation angle, wherein the optical The element provides a first optical magnification for light entering the optical element at an angle other than the activation angle, and a second optical magnification 'for light entering the optical element at an angle within the activation angle, and b ) Move the multifocal lens on the eye, and the first focus or the second focus is selectively located on the center of the retina of the eye. 19. The method of claim 18, wherein the optical lens is an ophthalmic lens and has a stabilization mechanism so that the lens can be stably moved from one position to another. 20. The method of claim 18, wherein the holographic optical element diffracts up to 100% of incident light when Bragg conditions are met. 21. The method of claim 18, wherein the abnormal refractive state is nearsightedness, farsightedness, presbyopia, regular or irregular astigmatism, or a combination thereof. 22. The method according to item 21 of the patent application, wherein the abnormal refractive state is a state of presbyopia and the first optical magnification is selected from +10 to -20 diopters. 23. —A method for manufacturing a multifocal optical lens for correcting an abnormal refractive state, the lens has a front curve and a bottom curve ', and the method includes step 3 _ This paper is scaled by Zhongming «Home Kneading Rate (CNS) A4 Grid < 210 > < 297 (concurrently) (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 4228 5 5 as C8 __D8 6. Scope of patent application a) introducing polymerizable optical material into the mold for optical lens; and b) exposing the polymerizable material in the mold to electromagnetic waves, where the electromagnetic waves form interference A stripe pattern, and at the same time the polymerizable material is polymerized, so that the pattern is recorded in the lens to form a volume grating structure, thereby forming a volumetric holographic element, which when placed on, in or before the eye, The pattern diffracts light entering the front curve to correct the abnormal refractive state. 24. A biocompatible holographic element made from a crosslinkable or polymerizable prepolymer, wherein the prepolymer is polymerized or crosslinked within five minutes of exposure to a UV light source to form a non-fluid A biocompatible optical element in which the prepolymer is placed between a bottom and a top quartz slide (100 mm apart) and a UV light source is provided to measure the duration of crosslinking or polymerization. The UV light source is A 200 watt medium pressure mercury arc lamp and 18 cm above the top quartz slide. 25. The biocompatible holographic element according to item 24 of the patent application, wherein the prepolymer includes a polyvinyl alcohol derivative having a chemical formula I of 0.5% to 80% based on the number of hydroxyl groups of the polyvinyl alcohol Module: (Please read the notes on the back before filling in this card) * 1T. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Two or two standard-rate (CNS) A4 specifications (210X25 »? Mm) used in this paper are printed 88 88 ABCD Printed by the Consumers’ Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 4228 5 5 6. The scope of patent application Among them: R series has Lower alkylene with up to 8 carbon atoms, R1 based hydrogen or lower alkyl, and R2 based olefin based unsaturated, electron-drawing, copolymerizable groups, with up to 25 carbon atoms. For example, the biocompatible holographic element with the scope of application for the patent No. 25, wherein R2 is an olefin-based unsaturated fluorene group of formula R3-CO, and R3 is an olefin-based unsaturated copolymerizable group having 2 to 24 carbon atoms . 27. The biocompatible holographic element according to item 26 of the application, wherein the olefin is unsaturated, copolymerizable, vinyl, 2-propenyl, 3-propenyl, 2-butenyl, Alkenyl, octenyl or decenyl. 28. The biocompatible holographic element according to item 24 of the application, wherein the prepolymer is crosslinked or polymerized within one minute. 29. The biocompatible holographic element according to item 24 of the application, wherein the prepolymer is crosslinked or polymerized within 30 seconds. 30. The biocompatible holographic element according to item 24 of the patent application, wherein the prepolymer includes a derivative containing polyvinyl alcohol, polyethyleneimine, or a nitrogen-containing heterolactone component of polyvinylamine, the derivative The number of hydroxyl groups in polyvinyl alcohol or the number of imine or amine groups in polyethyleneimine or polyvinylamine is 5 (please read the precautions on the back before filling this page) This paper is based on national standards (CNS) A4 (21〇 × 297 mm) 4Z28 5 5 A8 B8 C8 D8 6. The scope of patent application is 0.5 to 80% of the chemical formula IV and V unit R4 (IV) CR—C—R (Please read the notes on the back before filling this page) (V) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economy Ο R NH—C—C—CH, • c = o Rr? -R2 L-LLc, whose center and R2 are independently hydrogen, CrCs alkyl, aryl or cyclohexyl; R3 is hydrogen or C "c8 alkyl; and R4 is -0 or -NH- bridge. 31. 如The biocompatible holographic element of the 24th scope of the patent application, the paper size of the paper, using China National Standard (CNS) A4 specification (210X297 mm) 4228 5 5 ABCD VI. Patent application, where the prepolymer includes A functional copolymer comprising ethylene lactam and a second ethylene monomer, wherein the ethylene lactam is a five- to seven-membered linamine of chemical formula VII (Please read the notes on the back before filling out this page) The Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs has printed an alkylene bridge in which Ra is 2 to 8 carbon atoms; Rb is hydrogen, alkyl, aryl, Aralkyl or alkaryl, preferably hydrogen, lower alkyl with up to 7 carbon atoms, aryl with up to 10 carbon atoms, or aralkyl or alkaryl with up to 14 carbon atoms; And is hydrogen or lower alkyl with up to 7 carbon atoms. 32. The biocompatible holographic element according to item 31 of the application, wherein the ethylene lactam is N-ethylene-2-pyrrolidone, N-ethylene-2-caprolactam, N-ethylene- 3-methyl-2-pyrrolidone, N-ethylene-3-methyl-2-piperidone, N-ethylene-3-methylcaprolactam, N-ethylene-4-methyl-2- ¾loridone, N-ethylene-4-methyl-2-caprolactam, N-ethylene-5-methyl-2-pyrrolidone, N-ethylene-5-methyl-2-piperidone , N-ethylene-5,5-dimethyl-2-pyrrolidone, N-ethylene-3,3,5-trimethyl-2-pyrrolidone, N-ethylene-5-methyl-5- Ethyl_2 · pyrrolidone, N-ethylene-3,4,5-trimethyl-3-ethyl_2-pyrrolidinone, N-ethyl_6_methyl-2-nidone , N-ethyl-2--6-ethyl-2-natridone, N-ethyl-2,5-methyl-2-pyridine, N-ethyl-4,4--methyl- 2- □ Feikouding 7 This paper size is applicable to China's impoverished family # 准 （CNS） A4 wash grid （2 丨 OX297 mm） Λ228 5 5 A8 B8 C8 D8 6. Application scope of patent Ketone, N-ethylene_7_A Methyl-2-caprolactam, N-ethylene-7-ethyl-2-caprolactam, N-ethylene_3,5_dimethyl-2-caprolactam, N-ethylene-4, 6_dimethyl-2-caprolactam N- vinyl-3,5,7-trimethyl-2-caprolactam, or mixtures thereof. 33. For example, the biocompatible holographic element No. 31 of the scope of the application for patent, wherein the second ethylene single system is a functional ethylenic monomer having a vinyl group and a functional group, wherein the functional group is a hydroxyl group, an amine group, a low Alkyl substituted amine, residue'esterified carboxyl, alkoxycarbonyl, epoxy or sulfo. 34. The biocompatible holographic element according to item 32 of the patent application, wherein the functional ethylene monosystem is selected from the group consisting of hydroxyl-substituted lower acrylic acid and alkyl methacrylate, ethoxylated acrylic acid and alkyl methacrylate, Epoxy-lower acrylic and meth. Alkyl acrylate, epoxy cycloalkyl-lower acrylic and alkyl methacrylate, hydroxy-substituted lower alkyl acrylamide and methacrylamide, hydroxy-substituted Lower alkyl vinyl ether, amine- or hydroxy-substituted styrene, sodium ethylenesulfonate, sodium styrenesulfonate, 2-propenylamino-2-methylpropanesulfonic acid, acrylic acid, methacrylic acid, amine -Lower alkyl and alkylamino-lower acrylic and alkyl methacrylates, allyloxy- and methacryloxy-lower alkylmaleimide, and allyl alcohol. 35. A biocompatible volume holographic element made from a crosslinkable or polymerizable prepolymer, wherein the prepolymer forms a volume holographic element when exposed to parallel object light and a reference beam, Wherein the prepolymer is polymerized or cross-linked within five minutes of the UV light source to form a non-fluid biocompatible optical element, and the prepolymer is placed on the bottom and top quartz slides (they are separated by l 〇〇im) and provide a UV light source to measure the duration of cross-linking or polymerization, the UV light source is 200 watts moderate pressure 8 paper standard speed China National Standards (CNS) A4 specifications (2 丨 0X297 (Mm) (Please read the notes on the back before filling out this page) Printed by the Consumers ’Cooperative of Intellectual Property Bureau, Ministry of Economic Affairs 4228 5 5 A8 Β8 C8 D8 VI. Scope of patent application Force mercury arc lamp and 18 cm above the top quartz slide. (Please read the notes on the back before filling out this page) 36. If the biocompatible holographic element in the scope of patent application No. 35, it is a transmission holographic element "3 Enter the biocompatible phase in the scope of patent application No. 35 Capacitive holographic element for use in applications where the holographic element is placed in or on the eye. 38. A holographic element made of a crosslinkable or polymerizable prepolymer, wherein the prepolymer is a fluid prepolymer and forms a holographic element when exposed to parallel object light and a reference beam, Wherein the prepolymer is polymerized or crosslinked within five minutes of irradiation with a UV light source to form a hydrogel element, and wherein the prepolymer is placed between the bottom and top quartz slides (they are 100m apart) and a UV is provided A light source to measure the duration of cross-linking or polymerization. The UV light source is a 200 watt medium pressure mercury arc lamp and is placed 18 cm above the top quartz slide. 39. — A method for manufacturing a holographic element, comprising the steps of providing a crosslinkable prepolymer or a polymerizable monomer composition in a mold, wherein the prepolymer and the monomer composition are fluids, and providing The light beam is printed with a record of the holographic grating structure of the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, in which the fluid prepolymer or monomer is converted into a non-fluid element within five minutes of UV light, and the prepolymer is placed on the bottom A UV light source is provided between the top quartz slide (100 mm apart) and a UV light source for measuring the duration of the transition. The UV light source is a 200 watt medium pressure mercury arc lamp and is placed above the top quartz slide. 18 Public office. 40. The method of claim 39, wherein the holographic grating structure is a volume holographic grating structure. 41. If the method of applying for item 39 of the scope of the patent is applied, where the prepolymer group _9____ is used in the Zhongming National Standard (CNS) A4 specification (210 > < 297mm) " " 2 2 10ab, cd 6. The scope of the patent application includes derivatives of polyvinyl alcohol, which is based on the number of hydroxyl groups of polyvinyl alcohol and has 0.5% to 80% of units of formula I: Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs: R is a lower alkylene group with a maximum of 8 carbon atoms, R1 is a hydrogen or lower alkyl group, and R2 is an olefinic unsaturated, electron-pulling, copolymerizable group , With up to 25 carbon atoms. 42. The method according to claim 39, wherein the prepolymer composition includes a derivative containing polyvinyl alcohol, polyethyleneimine, or a nitrogen-containing heterolactone component of polyvinylamine, and the derivatives are respectively polymerized Based on the number of hydroxyl groups in vinyl alcohol or the number of imines or amine groups in polyethyleneimine or polyvinylamine, containing 0.5 to 80% of units of chemical formula IV and V: _10_ This paper size applies to China National Standards (CNS) Α4ΪΙ （） ~ --L -------- ί ------- IT ------ ^ 1 (Please read the notes on the back before filling this page) 4228 5 5 ABCD Scope of patent application \ ^ 0 IR—C—R. (IV) 0 R Π μ NH—C—C = CH -CH-CH, -NC = 0 IR 「C—R, (V) (Please read the Please fill in this page again, 1T 0 R, II 1] NH—C—C = CH. '2 The employee's consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs prints that its center and r2 are independently hydrogen, CrC8 alkyl, and aryl. Or cyclohexyl; R3 is hydrogen or CrC8 alkyl; and R4 is -0 or -NH- bridge. 43. The method of claim 39, wherein the prepolymer composition includes an ethylene linamide And the second vinyl monomer Copolymer, in which the ethylene lactam is a five to seven-membered lactam of the chemical formula VII 11 This paper size is applicable to China National Standard (CNS) A4 (210X297 mm) 4228 5 5 as C8 D8 VI. Application Patent scope Wherein it is an alkylene bridge having 2 to 8 carbon atoms; Rb is hydrogen, alkyl, aryl, aralkyl, or alkaryl, preferably hydrogen, lower alkyl having up to 7 carbon atoms, having Aryl groups with up to 10 carbon atoms, or aralkyl or alkaryl groups with up to 14 carbon atoms; and cardiac hydrogen or lower alkyl groups with up to 7 carbon atoms. (Please read the precautions on the back before filling this page)-丨. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs This paper is scaled to the Chinese National Standard (CNS) A4 (210 X 297 mm)