告 1： ^ a. 2 4 A7 B7 經濟部中央標準局貝工消资合作社印製 明Γ ” 申請案 ~中又詋明書修正I(M年3月） 發明範圍 本發明係有關於一種殺蟲劑及殺壁蝨劑组合物，其所含 活性成份4-溴-2，(4-氣苯基）-1-(乙氧基甲基）-5-(三氟甲基） p比洛-3-腈[在此處稱爲氣分那必（chl〇rfenapyr )]並加上第 二種殺蟲及殺壁蝨成份，可特別有效應用於農園藝界。 發明背景 氣分那必係本·發明之殺蟲劑及殺壁蝨劑組合物的一種活 性成份’已知能有效對抗下列昆蟲，如半翅目（Hemiptera) 害蟲，如葉蟬[豆透協發例大（Doltocephalidae)]、鱗翅目 (Lepidoptera)害蟲，如鎖·斑小菜蛾[小菜蛾（Plutel laxylostella)]、普通切根蟲[斜纹夜蛾（Spodoptera litura)]及 顏果潜葉蟲[飛.婁諾立歐特林構尼拉（Phyllonorycter ringoniella)]及纓翅類（Thysanoptera)害蟲，如棕搁薊馬 (Thrips palmi)及黃茶樹薊馬[斯迫托薊馬多爾撒莉絲 (Spirtothrips dorsalis)]及農園藝害蟲，如壁蝨，如普遍紅葉 蜗[棉葉减（Tetranychus urticae koch)]、硃砂蜗（Tetranychus cinnabarinus)[薄斯杜（boisbuval)]、堪閘娃虫高（Kanzawa spider mite)[堪閘娃科意緒達棉葉蛾（Tetranychus kanzawai kishida) 及阿庫樂普私培類嗔西（Aculops pelekassi)。 本發明之殺蟲劑及殺壁蝨劑組合物的第二活性成份包括 一或多種下列化合物： 1) 甲脒類化合物，如3-甲基-1,5-雙（2,4-二甲苯基）-1，3,5-三氮戊-1，4-二烯[三亞蟎（amitraz)]、N，-(2-甲基-4-氯 基苯基）-N，N-二曱基-甲脒氫氣化物[氣苯秘定（Chlorfen- -4- 本紙張尺度適用中®围家標準（CNS) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂' 421578 A 7 _____B7 五、發明説明（2 ) ~~ amidine)]及其類似物，已知能有效對抗農園藝害蟲，如 半翅目害蟲及壁蝨之化合物； 2) 有機硫類化合物，如2,4,5,4'-四氣二苯基減[得脱虫禹 (tetradifon)]、p-氣苯基、p-氯苯磺酸鹽（CPCBS )及其類 似物’已知爲有效之殺蟲劑及殺壁蝨劑； 3) 硫胺甲酸酯類化合物，如S-4-苯氧基丁基-二甲基疏 胺甲酸酯[分諸赛歐碳（fenothiocarb )]及其類似物，已知能 有效對抗多種農園藝害蟲； 4) 異丙基4,4匕二溴二苯乙醇酸鹽（苯異三溴苯酚鹽）， 已知能有效對抗昆蟲及壁蝨害蟲； 5) 5·氣-N-{2-[2,3-二甲基-4-(2-乙氧基乙基）苯氧基]乙 基}-6-乙基-4-嘧喊氨（密定分），已知能有效對抗半翅目及 鱗翅目害蟲及壁蝨； 6) (10E514E,16E,22Z)-(1R,4Sj5,S,6R,6,R,8R)13Rj20R>21R} 248)-21，24-十二羥基-5|，6_，11，13,22-戊基甲基-3,7，19-三氧雜 四環[15.6.1.14 8.02〇,24]二十五基-10，14，16,22-四烯-6-螺旋-2，-四氫吡喃-2-酮及（10E,14E，16E，22Z)-(1R,4S，5_S,6R，6，R，8R， 13尺，2011，2111，243)-6，-乙基-21，24-二羥基-5|，11，13,22-四曱基 -3,7，19-三氧雜四環[15.6.1.14 8.〇2〇,24]二十五基-1〇，14，16, 22-四缔-6-螺旋-2_-四氫吡喃-2-酮（密歐幣枚可汀）之3 ·· 7混 合构，已知能有效對抗農園藝壁蝨，如葉蟎總科；及 7) 二硝基苯酚類化合物，如丁烯酸二硝基甲基庚基苯 酯{在此處稱爲DPC [白粉克（Dinocap)]} ’已知能有效對 抗農園藝壁蝨，如葉蟎總科及農園藝病原性黴菌，如粉 本紙張尺度適用中国囤家標準（CNS ) Λ4規格（210X297公釐） ~'請1閱讀背面之注意亨項再填窍本頁 -訂一 經濟部中央標準局員工消費合作杜印製 421578 A7 _ _B7 五、發明説明（3 ) 酶。 雖然已發展出殺蟲劑及殺壁蝨劑以控制不同害蟲，如農 園藝害蟲或公共衛生上之害蟲並以單獨或混合藥物實際應 用’但重複使用這些藥物的結果已出現對各種藥物具獲得 性抗藥性的害蟲。 特別是農園藝上之重要經濟害蟲，如葉喊總科，其容易 對殺蟲劑發展出抗藥性的傾向係由於它們能產下大量卵並 製造大量後代的能力，而這些後代僅需數日即可發育完成 也是主要的原因。而高突變率及由於較少移行而經常產生 之近親交配亦有助於此類害蟲發展抗藥性。因此，普遍紅 葉蟎（棉葉蟎）、堪閘娃蟎（堪閘娃科意緒達棉葉蟎）及阿庫 樂普私培類嗔西，及其類似具獲得性抗藥性的害蟲，於某 程度上幾乎可對抗所有現存殺蟲劑。因此，爲預防及控制 由葉减總科造成的損害，非常需要發展新型可強力對抗具 傳統殺壁蝨劑獲得性抗藥性之葉輔總科的殺蟲劑及殺壁蝨 劑。 經濟部中央標準局負工消費合作社印取 然而，欲獲得與現存之殺蟲劑及殺壁蝨劑無交叉抗藥性 且無毒性問題並對環境僅有少數負面影響之殺蟲劑及殺壁 蝨劑組合物極爲不易。因此，人們一直在尋找延遲或預防 抗藥性型害蟲發展的方法。爲了要盡可能延長有效藥物之 應用期限’在良好的實際應用管理上應輪流使用不同反應 機制的藥物。然而’此應用方式並不能完全滿足害蟲防 治。因此，發生抗藥性問題後，人們開始研究藉由併用殺 蟲劑及殺壁蝨劑以對抗抗藥性的對策。然而，高協同反應 -6 - ^紙張尺度適用中闺0苳標聲"_(<^5'7^見格（2丨〇\297公舞） 經濟部中央標準局員工消费合作社印製 421578 Λ 7 Β7 五、發明説明（4 ) 並非經常會被發現。 雖然如此，氣分那必係一種目前的高效性殺壁蝨劑，最 近被引入農化市場’且就如同經常發生於其他過去的新型 殺蟲劑化合物一樣地終將產生抗藥性的問題。 因此，本發明之目的之一係提供一種殺蟲劑及殺壁蝨劑 组合物，其顯示即使對已獲得抗氯分那必之抗藥性的葉虫凑 總科亦有高控制效果。 發明摘要 爲了在葉蟎總科對氣分那必抗藥性的問題發生前建立對 策，使用在實驗室中人工培養選取之以氣分那必處理過的 具抗藥性之葉蟎總科品種來研究現存殺蟲劑、殺壁蝨劑及 殺黴菌劑的協同反應。因而發現含活性成份氣分那必與一 或多種由某特定殺蟲劑及殺壁益劑成份群組中選出之殺蟲 劑及殺壁蝨劑化合物之組合物顯示由每一單獨成份無法見 到的聯合反應或協同作用。也就是説，本發明發現的殺蟲 劑及殺壁蝨劑組合物，其所含活性成份氣分那必與一或多 種選自包含甲脒類殺蟲劑及殺壁蝨劑、有機硫類殺蟲劑及 殺壁蝨劑、硫胺甲酸酯類殺蟲劑及殺壁蝨劑、苯異三溴苯 酚鹽、密定分、密歐幣枚可汀及丁烯酸二硝基甲基庚基苯 酯（此後稱爲A組）群組中之化合物。 發明詳述 氣分那必，係本發明之殺蟲劑及殺壁蝨劑组合物的一種 活性成份，爲一種知名化合物{日本保留公開（Laid-open) [可凱（Kokai)]專利第104042/S9號}。適用爲本發明組合 本紙張尺度適州t國因家標净（CNS ) Λ4規格（210X 297公釐） (請先閱請背'"之注意事項再填寫本瓦) 訂---- 421578 經濟部中央標準局貝工消費合作社印製 A7 _ 87 ____五、發明説明（5 ) 物第二種活性成份之化合物，如一種或多種下列化合物·· 1 ) 甲脒類化合物，較佳爲三亞蟎及氣苯秘定； 2) 有機硫類化合物，較佳爲得脱蟎（teradifon)及對氣 萃績酸對氣苯基醋； 3) 硫胺甲酸酯類化合物，較佳爲分諾赛歐碳 (fenothiocarb)； 4) 苯異三溴苯酚鹽； 5 ) 密定分； 6 ) 密歐带牧可ΐ丁及 7) 丁烯酸二硝基甲基庚基苯酯 皆爲知名化合物及已商品化產品。 對本發明之殺蟲劑及殺壁蝨劑組合物的製備，適於調配 成爲可潤濕粉末、水性濃縮劑、乳劑、液態濃縮劑、溶膠 (可流動藥劑）、粉末、煙霧劑或其類似物，藉傳統方法， 如混合氯分那必與一或多種Α組化合物及適當載劑及輔助 劑，如乳化劑、分散劑、安定劑、懸浮劑、滲透劑及其類 似物。 本發明總活性成份之含量以重量％表示，對可潤濕粉 末、水性濃縮劑、乳劑、液態濃縮劑及溶膠調配物之較佳 範圍爲約1-90%。對粉末調配物總活性成份之較佳成份爲 約0:5-10%，而對煙霧劑調配物爲約0.01-2%。 適用於本發明殺為劑及殺壁兹劑組合物之載劑可爲一般 應用於農園藝組合物之任何固體或液體載劑。可根據需要 應用各種表面作用劑、安定劑及其它輔助成份。於商業實 -8 - 本紙張尺度適州中國1¾家標李（CNS ) Λ4規格（210Χ_297公釐) ~ (請先閱讀背面之注意事項再填寫本頁) 42157 8 A7 B7 五、發明説明（6 ) 用配方物中，本發明組合物也可與其它活性藥物同存於混 合物中，如各種殺蟲劑、殺壁益劑、殺黴菌劑及除草劑、 植物生長調節劑、驅蟲劑、吸引劑、增效劑及肥料及香 料，以便擴展其應用性。 本發明之殺蟲劑及殺壁蝨劑組合物中的氣分那必與A組 化合物的比率爲約1份重量的氣分那必比約〇.〇丨_100 (較佳 爲約0· 1 -20 )份重量的A组化合物。 本發明之殺蟲劑及殺壁蝨劑组合物對控制葉蟎總科，如 普遍紅葉蛾（棉葉蜗）、[珠砂蜗（Tetranychus cinnabarinus) [玻意斯疊歐（boisduyal)]}、堪閘娃蟎[堪閘娃科意緒達棉 葉蛾]、[維尼西斯察卻蜗（Tetranichus viennensis zacher )] 及其類似物特別有效。 更有利的是，本發明之殺蟲劑及殺壁蝨劑组合物不僅顯 示對抗上述葉蟎總科之協同殺壁蝨劑作用，亦顯示同時控 制麻煩的害蟲，如捲葉蛾[托爾吹西科（Tortricidae )]、卡 爾坡席科（Carposinidae)、{潛葉蛾[里歐異提科 (Lyonetiidae)]} 、{植物蟲（plant bugs)[片塔通科 (卩61^1；011^(1&6)]}{虫牙蟲[对蟲科（八1)1^心(1&6)]}、{葉輝[疊 爾透希發科（Deltociphalidae)]} ' {莉馬[莉馬科 (Thripidae)]}、鑽斑小菜蛾（小菜蛾）、蕓薹馬滅斯嚓 (M^mestra brassicae )、{葉甲益（leaf beetles)[克里鬼迷科 (Chrysomelidae)]} 、{白繩（whiteflies )[阿類羅得科 (Aleyro.didae)]}及其它類似危害重要農作物（果樹，如柑 橘屬植物、蘋果及梨子、茶樹、蔬菜及其類似作物）的害 -9- 本紙張尺度適州中國國家標率（CNS ) Λ4規格（210X 297公t ) (請先間讀背面之注意事項再填寫本頁) 丁 、v5. 經濟部中央標隼局員工消費合作社印製 A7 421 57 8 五、發明説明（7 蟲 雖然本發明组合物之使用量可能因流行情況而改變（如 目標作物的族群密度、品種及種植型態，天候狀況、施用 方法等），但一般來説，與A组化合物混合的氣分那必總 量約爲每10畝0.1-1，000克，較佳爲約40-500克。實際使用 上，當本發明之組合物型式爲可潤濕粉末、水性濃縮劑、 乳劑、液態滚縮劑、溶膠、或其類似物時，可以水稀釋且 以每1 0敌約100-700升的比例施用於作物上。當本發明組 合物調配成粉末或煙霧劑，可以非稀釋調配物處理作物。 本發明之殺蟲劑及殺壁蝨劑组合物可更進一步以下列實 例詳述之。這些實例並非欲限制本發明範圍。所有的份數 係以重量計。 實例1 調配實例1乳劑 氣分那必 10份 三亞蟎 30份 二甲苯 25份 二甲基甲醯胺 20份 賤爾波（Sorpol) 3005X 1 5份 [商品名。聚氧乙烯型表面作用劑。透荷化學工業有限 經濟部中央標率局員工消费合作社印黎 公司製（Toho Chemical Industry Co,s Ltd 均勻混合溶解上述成份後獲得一乳齊j。 實例2 調配實例2可潤濕粉末 -10 本纸依尺度適用中1¾¾家標準（C'NS ) Λ4規格（210><297公廣 A7 421578 B7 五、發明説明（8 ) 氣分那必 1 0份 得脱蟎 1 0份 卡爾蒲雷克斯（Carplex) #80 20份 [商品名。白碳。須歐裙吉有限公司製（Shionogi & Co.， Ltd)] 吉克來（Zeekiite) SP 5 2 份 [商品名。高嶺土及鋅破石特（cericite)之混合物。吉克 來工業製（Zeeklite Ind.)] 鈣木素磺胺鹽 8份 以噴射氣磨機均勻混合上述成份後獲得一可潤濕粉末。 實例3 調配實例3溶膠（可流動藥劑） 氣分那必 5份 分諾賽歐碳 25份 乙二醇 8份 颼爾波AC3020 5份 (透荷化學工業有限公司製， 商品名） 黃膠（Xanthan gum) 0.1份 水 56_9 份 將氣分那必、分諾赛歐碳與乙二醇、颼爾波AC3020及 黃野之預製混合物在水中充分混合分散。随後以迪諾研磨 機（Dynomill，勳馬錄實業（Shinmaru Enterprises)]潮濟研 磨此水漿，獲得一溶膠（可流動藥劑）。 上述每一調配物皆適合作爲農業化學劑。 -11 - ___________— 本紙張尺度適用中國國家標準（CNS ) A4規格（2l〇x 29?公釐） (請先閱讀背面之注意事項再填寫本頁) 訂， 經濟部中央標準局員工消費合作社印裝Report 1: ^ a. 2 4 A7 B7 Printed by the Central Government Bureau of Standards, Ministry of Economic Affairs, Shellfish Consumer Cooperatives, and printed "Γ" Application ~ Amendment to the Book of Amendment I (M, March M) Scope of the Invention The present invention relates to a kind of killing Insecticide and tick composition, containing active ingredient 4-bromo-2, (4-aerophenyl) -1- (ethoxymethyl) -5- (trifluoromethyl) p-bilo- 3-nitrile [herein referred to as chorfenapyr], together with the second insecticidal and tick-killing ingredients, can be particularly effectively applied to the agricultural and horticultural community. BACKGROUND OF THE INVENTION An active ingredient of the inventive insecticide and tick composition is known to be effective against insects such as Hemiptera, such as leafhoppers [Doltocephalidae], Lepidoptera ( Lepidoptera) pests, such as Plutella xylostella [Plutel laxylostella], common root-cutting insects [Spodoptera litura], and leaf fruit [Fly. Lou Nuoli Otellini] (Phyllonorycter ringoniella)] and Thysanoptera pests, such as Thrips palmi and yellow tea tree thrips (Spirtothrips dorsalis) and agricultural and horticultural pests, such as ticks, such as the common red leaf snail [Tetranychus urticae koch], cinnabar snail (Tetranychus cinnabarinus) [boisbuval], Kanzha high insect ( Kanzawa spider mite) [Kanzawa spider mite (Tetranychus kanzawai kishida) and Aculops pelekassi. The second insecticide and tick composition of the present invention Active ingredients include one or more of the following compounds: 1) Formazan compounds such as 3-methyl-1,5-bis (2,4-xylyl) -1,3,5-triazapentane-1,4 -Diene [amitraz], N,-(2-methyl-4-chlorophenyl) -N, N-difluorenyl-formamidine hydrochloride [Chlorfen- -4 -This paper size is applicable to the Chinese Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before filling this page) Order '421578 A 7 _____B7 V. Description of the Invention (2) ~~ amidine) ] And its analogs, compounds known to be effective against agricultural and horticultural pests, such as hemiptera pests and ticks; 2) organic sulfur compounds, such as 2,4,5,4'-tetrakis Phenyl minus [tetradifon], p-phenyl, p-chlorobenzenesulfonate (CPCBS) and their analogs are known to be effective insecticides and ticks; 3) Sulfur Carbamate compounds, such as S-4-phenoxybutyl-dimethyl sulfamocarbamate [fenothiocarb] and their analogues, are known to be effective against a variety of agricultural and horticultural pests; 4 ) Isopropyl 4,4 dibromodiphenyl glycolate (phenyl isotribromophenolate), known to be effective against insects and tick pests; 5) 5 · qi-N- {2- [2,3-di Methyl-4- (2-ethoxyethyl) phenoxy] ethyl} -6-ethyl-4-pyrimidine (Mididine), known to be effective against pests of Hemiptera and Lepidoptera and Ticks; 6) (10E514E, 16E, 22Z)-(1R, 4Sj5, S, 6R, 6, R, 8R) 13Rj20R > 21R} 248) -21,24-dodecylhydroxy-5 |, 6_, 11,13 , 22-pentylmethyl-3,7,19-trioxatetracyclo [15.6.1.14 8.02〇, 24] pentadecyl-10,14,16,22-tetraene-6-spiral-2, -Tetrahydropyran-2-one and (10E, 14E, 16E, 22Z)-(1R, 4S, 5_S, 6R, 6, R, 8R, 13 feet, 2011, 2111,243) -6, -ethyl -21,24-dihydroxy-5 |, 11,13,22-tetrafluorenyl-3,7,1 9-trioxatetracyclo [15.6.1.14 8.〇2〇, 24] pentadecyl-1, 10, 14, 16, 22-tetra-6-helix-2_-tetrahydropyran-2-one (Milco-cotin) 3 ·· 7 mixed structure, known to be effective against agricultural and horticultural ticks, such as the spider mite family; and 7) Dinitrophenol compounds, such as butenoic acid dinitromethylheptan Phenyl phenyl ester {herein referred to as DPC [白粉 克 (Dinocap)]} 'is known to be effective against agricultural and horticultural ticks, such as Tetranychidae and agro-horticultural pathogenic molds. CNS) Λ4 specification (210X297 mm) ~ 'Please read the note on the back of the item and fill in the tips on this page-order one of the consumer cooperation of the Central Bureau of Standards of the Ministry of Economic Affairs Du printed 421578 A7 _ _B7 V. Description of the invention (3) Enzymes . Although insecticides and ticks have been developed to control different pests, such as agricultural and horticultural pests or public health pests, and have been put into practical use as separate or mixed drugs, the results of repeated use of these drugs have appeared to be available for various drugs Resistant pests. In particular, important economic pests in agriculture and horticulture, such as the leaf family, have a tendency to develop resistance to pesticides because of their ability to lay a large number of eggs and produce a large number of offspring, and these offspring only need a few days The development is complete is also the main reason. High mutation rates and inbreeding that often occur due to less migration also help these pests develop resistance. Therefore, the red spider mite (Cotton mite), Kanzha baby mite (Kanzhaidae Ishida cotton spider mite), and Akulep's private breeding species Xixi, and similar insect pests with acquired resistance, are widespread. To some extent against almost all existing pesticides. Therefore, in order to prevent and control the damage caused by the Acanthaceae, there is a great need to develop new insecticides and tickicides that can strongly resist the Acanthostomide which has acquired resistance to traditional ticks. Printed by the Consumer Standards Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs Things are extremely difficult. As a result, people are always looking for ways to delay or prevent the development of resistant pests. In order to prolong the application period of effective drugs as far as possible ', drugs with different response mechanisms should be used in turn in good practical application management. However, ‘this application does not fully satisfy pest control. Therefore, after the problem of drug resistance occurred, people began to study countermeasures against drug resistance by using a combination of insecticides and ticks. However, the high synergy response -6-^ Paper scale is suitable for the girl's 0 声 standard sound " _ (&^; 5'7 ^ Jiange (2 丨 〇 \ 297 公 舞) Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 421578 Λ 7 Β7 V. Invention description (4) is not often found. However, Qi Fen Na must be a current high-efficiency tick killer, which has been recently introduced into the agrochemical market, and it often happens in other past The new insecticide compounds will eventually cause the problem of resistance. Therefore, one of the objects of the present invention is to provide an insecticide and tick composition which shows the resistance even to the anti-chlorpheniramine It also has a high control effect. Abstract: In order to establish countermeasures against the problem of resistance to gas fractions and naphthas of the spider mite population, it is necessary to use artificial cultivation in the laboratory to select the gas fractions that must be treated. Drug-resistant spider mite species to study the synergistic response of existing pesticides, ticks, and fungicides. Therefore, it was found that the active ingredient gas fraction must be combined with one or more specific pesticides and wall killers. Agent group The selected combination of insecticides and tick compounds shows a joint reaction or synergy that is not seen by each individual ingredient. That is, the pesticide and tick composition found in the present invention contains The active ingredient Qifennabe must be selected from the group consisting of formazan insecticides and tick insecticides, organic sulfur insecticides and tick insecticides, thiocarbamate insecticides and tick insecticides, benzene isocyanate Compounds in the group of tribromophenate, midine, meiocotin, and dinitromethylheptylphenyl butenoate (hereinafter referred to as group A). Detailed description of the invention An active ingredient of the insecticide and tick composition of the present invention is a well-known compound {Laid-open [Kokai] Patent No. 104042 / S9}. It is suitable for the combination of the present invention The size of this paper is suitable for China National Standard Net (CNS) Λ4 specifications (210X 297 mm) (please read the "Notes" before filling in this tile) Order ---- 421578 Central Standards Bureau, Ministry of Economic Affairs A7 printed by Shelley Consumer Cooperative _ 87 ____ 5. Description of the invention (5) Second kind of activity Ingredient compounds, such as one or more of the following compounds ... 1) Formazan compounds, preferably Sanya mite and Benzene; 2) Organic sulfur compounds, preferably teradifon and gas extraction Phenyl vinegar; 3) Thiamine compounds, preferably fenothiocarb; 4) Benzisotribromophenate; 5) Midine fraction; 6) Mesozoic Butanidine and 7) Dinitromethylheptyl phenyl butenoate are well-known compounds and commercialized products. The preparation of the insecticide and tick composition of the present invention is suitable for formulating into a wettable powder, an aqueous concentrate, an emulsion, a liquid concentrate, a sol (a flowable agent), a powder, an aerosol or the like, By conventional methods, such as mixing chlorpheniramine with one or more Group A compounds and appropriate carriers and adjuvants, such as emulsifiers, dispersants, stabilizers, suspending agents, penetrants, and the like. The content of the total active ingredient of the present invention is expressed by weight%, and the preferred range for wettable powder, aqueous concentrate, emulsion, liquid concentrate and sol formulation is about 1-90%. The preferred ingredient for the total active ingredient of the powder formulation is about 0: 5-10%, and about 0.01-2% for the aerosol formulation. Carriers suitable for use in the pesticides and bibicide compositions of the present invention may be any solid or liquid carrier generally used in agricultural and horticultural compositions. Various surface active agents, stabilizers and other auxiliary ingredients can be applied as required. Yu Shi Shi-8-This paper is in Shizhou China 1¾ standard Chinese standard (CNS) Λ4 specification (210 × _297 mm) ~ (Please read the precautions on the back before filling out this page) 42157 8 A7 B7 V. Invention Description (6 ) In the formulation, the composition of the present invention can also be coexisted in the mixture with other active drugs, such as various pesticides, wall killers, fungicides and herbicides, plant growth regulators, insect repellents, attractants Additives, synergists and fertilizers and spices in order to expand their applicability. The ratio of fenapride in the insecticide and tick composition of the present invention to the compound of group A is about 1 part by weight. The fenapeptide ratio is about 0.001 to 100 (preferably about 0.1). -20) parts by weight of the compound of group A. The insecticide and tick composition of the present invention is useful for controlling the spider mite family, such as the common red leaf moth (Cottonia snail), [Tetranychus cinnabarinus] [Boisduyal]}, Zhawa mites [Kanzawaidae Esoda cotton leaf moth], [Tetranichus viennensis zacher] and their analogs are particularly effective. More advantageously, the insecticide and tick composition of the present invention not only shows a synergistic tick killing effect against the above-mentioned spider mite family, but also shows the simultaneous control of troublesome pests, such as the leaf roller moth [Torchidae )], Carposinidae, {Leaf miner [Lyonetiidae]}, {Plant bugs [Planttonidae (卩 61 ^ 1; 011 ^ (1 & 6)]} {worm toothworm [to insect family (eight 1) 1 ^ heart (1 & 6)]}, {叶辉 [Deltociphalidae]] '' {莉马 [莉马科 ( Thripidae)]}, Diamondback moth (Plutella xylostella), M ^ mestra brassicae, {leaf beetles [Chrysomelidae]}}, {whiteflies ) [Aleyro.didae]} and other similar hazards to important crops (fruit trees, such as citrus plants, apples and pears, tea trees, vegetables and similar crops) -9- China National Standards (CNS) Λ4 specification (210X 297gt) (please read the precautions on the back before filling out this page) D, v5. Staff Consumption of Central Bureau of Standards, Ministry of Economic Affairs Printed by Zhuozuosha A7 421 57 8 V. Description of the invention (7 Although the usage of the composition of the present invention may change due to epidemic situation (such as the population density, variety and planting type of target crops, weather conditions, application methods, etc.) However, in general, the total amount of gas fractions mixed with the compound of group A is about 0.1-1, 000 grams per 10 acres, preferably about 40-500 grams. In practical use, when the composition type of the present invention is When it is a wettable powder, an aqueous concentrate, an emulsion, a liquid rolling agent, a sol, or the like, it can be diluted with water and applied to crops at a rate of about 100-700 liters per 10 enemy. When the present invention is combined The ingredients are formulated into powders or aerosols, and crops can be treated with non-diluted formulations. The insecticide and tick composition of the present invention can be further described in the following examples. These examples are not intended to limit the scope of the invention. All parts The number is based on weight. Example 1 Formulation Example 1 Emulsion gas fraction Nabi 10 parts Trimite 30 parts xylene 25 parts dimethylformamide 20 parts Sorpol 3005X 1 5 parts [Trade name. Polyoxygen Vinyl type surface active agent Toho Chemical Industry Co, s Ltd (Toho Chemical Industry Co, s Ltd), a consumer cooperative of employees of the Central Standards Bureau, Ministry of Chemical Industry, Ministry of Economics, and the above ingredients are evenly mixed and dissolved to obtain a milk j. Example 2 Preparation Example 2 Wettable powder-10 The paper is based on 1¾¾ of the standard (C'NS) Λ4 specifications (210 > < 297 Gong A7 421578 B7) V. Description of the invention (8) 10 parts of the air fraction Nabi get 10 parts of mites斯 （Carplex) # 80 20 copies [Trade name. White carbon. Made by Shionogi & Co., Ltd] Zekiite SP 5 2 copies [Trade name. A mixture of kaolin and cericite. Zeeklite Ind.] 8 parts of calcium lignin sulfonamide salt The above ingredients are evenly mixed with a jet mill to obtain a wettable powder. Example 3 Preparation Example 3 Sol (Flowable Pharmacy) Gas Content Nabi 5 Parts Noseo Carbon 25 Parts Ethylene Glycol 8 Parts Sulbo AC3020 5 Parts (manufactured by Toho Chemical Industry Co., Ltd., Xanthan) gum) 0.1 parts of water 56-9 parts The premixed mixture of fenapridine, fenoxelocarbon and ethylene glycol, Puerbo AC3020 and Huangye are fully mixed and dispersed in water. Subsequently, this water slurry was ground with a Dynomill (Dynomill, Shinmaru Enterprises) to obtain a sol (flowable medicament). Each of the above formulations is suitable as an agricultural chemical. -11- ___________— This paper size applies to China National Standard (CNS) A4 (2l0x 29? Mm) (Please read the precautions on the back before filling this page) Order, printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs
421578 V) 9 ) 實例4 測試實例1 於此實驗中，評估對抗堪閘娃蟎[堪閘娃科意緒達棉葉 虫禹]的雌成蟲（抗氣分那必種）的殺壁蟲劑作用。 以葉片打孔機自蠶豆的初葉上切下圓形葉片（直後2公 分），並將四張葉片置於塑膠杯（直徑8公分）中的潮濕消毒 棉化上。在每張葉片上接種4隻已獲得強力氯分那必抗藥 性的堪閘娃蜗[堪閘娃科意绪達棉葉喊]雌成蟲。 接種後，氣分那必及選自A組之化合物分散於含2〇〇 ppm增量劑（颼爾波3005X)的水中，並稀釋且事先測量獲 得其活性成份之濃度。每一塑膠杯用旋轉噴灑塔[米珠侯 科學有限公司（Mizuho Scientific Co‘，Ltd.)]噴灑3.5毫升之 測試溶液’並存放於維持在25 土 PC的恒溫箱中（每一渡度 測試3 2個獨立组，每一配方評估4_5種濃度，重複作2 次）。處理後二天，清數仍存活及死亡之已獲得強力氣分 那必抗藥性的堪閘娃蟎[堪閘娃科意緒達棉葉蟎]的雖成 蟲，並根據下列公式計算死亡率（％)。 死亡率（％ )= 死亡壁蝨的數目 存活壁蝨的數目+死亡壁蝨的數目 xlQ〇 利用這些數據’藉由常用之概率（probit)分析技術獲得 1^5〇値。以普遍用來測定協同作用程度的桑（Sun)及遭森 (Johnson )公式（J. Econ. Ent.，第53卷，第 887 頁，i960 年） 計算協同-毒性係數。 -12- 本紙張尺度適用中國國家橾车（CNS ) A4規格（210XM7公釐> 請 先 閲 讀 背 之 注 意 事 項 再 填 寫 本 頁 衣 訂 經濟部中央標準局員工消費合作社印裝 421578 . A7 _____ B7 經濟部中央標準局員工消費合作社印製 五、發明説明（彳o ) 組成本發明殺蟲劑及殺壁蝨劑組合物之每—單獨有效成 份之1^5〇値列於表I ^本發明組合物之L(：5q値及其協同-毒 性係數係顯示於表11。 協同-毒性係數=Te 混合物實際毒性指數 1---------- X 100 混合物理論毒性指數 T値大於100者，愈大的値顯示愈強之協同反應。τ<5値 等於100者’顯示加成反應。値小於1〇〇者，愈小的値顯 示愈強之拮抗反應。以下運用前述之桑與瓊森公式更詳細 描述協同-毒性係數的計算。 測定單獨之測試化合物A之1^5。値及單獨之測試化合物 B之LC5〇値’以及（A+B)混合物Μ之LC50値。 混合物Μ之實際毒性指數==Μ“ 利用有效成份Α與有效成份Β及Α + Β混合物之每一 LC50 値，如同下列等式所示來測定實際毒性指數。 A 之 LC50 Mn --- 100 Μ 之 LCS0 混合物Μ之理論毒性指數=Th.M11 Th.M11 = (A之毒性指數X Μ中之A%+B之毒性指數X Μ中 之Β%) Β之毒性指數=Β“ Α 之 LC50 Βύ =--- 100 B 之 LC50 Α之毒性指數=A11 -13- (請先閱讀背而之注意事項再填，"本頁) 1 ·1 i - -i ------ ·' 丁 ,vs 本紙張尺度適用中國國家標伞（CNS ) Λ4現格（210x297公釐） 經濟部中央標隼局員工消費合作社印裝 421578 * A7 ________B7 五、發明説明（11 ) Au = 100 表I 測試化合物對抗已獲氣分那必抗藥性之 堪閘娃蟎雌成蟲的作用評估 迦.琴1化合物 LC^n rppm^ 氣分那必 1500 二亞蜗 200 得脱蜗 4900421578 V) 9) Example 4 Test Example 1 In this experiment, a wall killer action against a female adult (anti-aerobic naphtha) against Kanzha baby mite [Kanzhaidae Ishida cotton leaf insect Yu] was evaluated. . Use a leaf punch to cut round leaves (2 cm straight) from the first leaves of broad beans, and place four leaves on a wet sterilized cotton cloth in a plastic cup (8 cm in diameter). Each leaf was inoculated with 4 adult females of Kanzhawa snails [Kanzawawa Isuda cotton leaf shouting] that had acquired strong resistance to clofenafil. After inoculation, Qifenabit and a compound selected from Group A were dispersed in water containing 200 ppm extender (Mirbo 3005X), diluted and measured in advance to obtain the concentration of its active ingredient. Each plastic cup was sprayed with 3.5 ml of test solution 'using a rotating spray tower [Mizuho Scientific Co', Ltd.] and stored in a thermostatic box maintained at 25 soil PC (for each fertility test) 3 2 independent groups, each formula evaluates 4-5 concentrations and repeats 2 times). Two days after the treatment, the adults who had acquired a potent fraction of the drug-resistant Kanzha mite [Kanzhako Isuoda cotton spider mite] that had survived and died after treatment were counted, and the mortality was calculated according to the following formula (% ). Mortality (%) = Number of dead ticks Number of surviving ticks + number of dead ticks xlQ〇 Using these data ', 1 ^ 50 was obtained by a common probit analysis technique. Synergy-toxicity coefficients were calculated using Sun and Johnson formulas (J. Econ. Ent., Vol. 53, p. 887, i960) commonly used to determine the degree of synergy. -12- This paper size is applicable to China's National Car (CNS) A4 specification (210XM7mm > Please read the precautions on the back before filling out this page. Binding printing by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. A7 _____ B7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the Invention () o) Each cost of the insecticide and tick composition of the invention—single active ingredient 1 ^ 50 値 is listed in Table I. ^ Combinations of the invention L (: 5q 値) and its synergistic-toxicity coefficient are shown in Table 11. Synergistic-toxicity coefficient = Te Mixture actual toxicity index 1 ---------- X 100 Theoretical mixture toxicity index T 値 is greater than 100 For larger tadpoles, a stronger synergistic response is shown. Τ <5 値 is equal to 100 ′ shows an addition reaction. For 値 smaller than 100, smaller tadpoles show a stronger antagonistic response. The following uses the aforementioned mulberry and The Jonson formula describes the calculation of the synergy-toxicity coefficient in more detail. Determine 1 ^ 5 of test compound A alone. 値 and LC50 値 'of test compound B alone and LC50 値 of (A + B) mixture M. Mixture M Actual Toxicity Index == Μ Use each LC50 有效 of active ingredient A and active ingredient B and A + Β mixture to determine the actual toxicity index as shown in the following equation: LC50 Mn of A --- 100 M LCS0 Theoretical toxicity index of mixture M = Th .M11 Th.M11 = (A% of A toxicity index X Μ + B% of toxicity index X B% of B) toxic index of β = β "LC50 of Α Βύ = --- LC50 of 100 B Α of Toxicity Index = A11 -13- (Please read the precautions and fill in this page first, " this page) 1 · 1 i--i ------ · 'Ding, vs This paper size applies to Chinese national standard umbrella (CNS) Λ4 is present (210x297 mm) Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs 421578 * A7 ________B7 V. Description of the invention (11) Au = 100 Evaluation of the role of adult females of Kanazawa mites. G. 1 compound LC ^ n rppm ^ Qifen Nabi 1500 Two subworms 200 Deworming 4900
Keltliane (卡爾先）[大克蜗(Dicofol)] 32 苯異三溴苯齡壤果酸鹽（Phenisobromalate)* 280 分語赛歐碳 1000 密定分 1〇 愛佛枚可汀（Avermectins) 0.13 密歐幣牧可汀 0.28 白蜗克(Binapacryl)a 180 DPC 630 * 2,4-二硝基-6-第二-丁基苯基二甲基-丙烯酸酯 經比較後，氯分那必抗易感型堪閘娃蟎之LC5◦値約爲5 ppm。 如表I數據所示，由野外聚落收集並以實驗室長時間人 工選擇所產生獲得之抗氣分那必型堪閘娃蟎，已發展出約 300倍的氣分那必抗藥性。 而對三亞蟎、苯異三溴苯酚鹽、拜那帕可萊及DPC來 説，推測這些收集自野外的堪閘娃蟎早己獲得對這些殺蟲 -14-_ 本紙張尺度適;fl中闽园家標隼（CNS ) Λ4規格（210/297公赞） (請先聞讀背面之注意事項再填寫本頁) 訂Ί 公告豕 …絛正I 42Ί578 ν’ 。^ '激方 五、發明説明（ 12) 經濟部中央標準局貝工消费合作杜印製 劑及殺壁兹劑抗藥性的聚落。這些化合物皆顯示低落的效 果。 測試化合物：卡爾先（迪可佛）、密定分、愛佛枚可汀及 密歐幣牧可汀於本實驗中皆顯示高殺璧蝨劑效果。 測試化合物得脱蟎及分諾赛歐碳於本實驗中顯示低殺壁 兹劑效果3Keltliane (Dicofol) 32 Phenisobromalate * Phenisobromalate * 280 points Sail Carbon 1000 Midine points 1 10 Avermectins 0.13 dense Eurocoin 0.28 Binapacryl a 180 DPC 630 * 2,4-Dinitro-6-Second-Butylphenyl Dimethyacrylate The LC5◦ of susceptible kansal mites is about 5 ppm. As shown in the data in Table I, the anti-aerobic nabbit mites, collected from field settlements and artificially selected by laboratories for a long period of time, have developed approximately 300 times the air-resistant anabida resistance. For Sanya mite, benzisotribromophenate, banapacole, and DPC, it is speculated that these Kanzhava mites collected from the field have long obtained these insecticides. 14-_ This paper is of a suitable size; fl Medium Min Garden House Standard (CNS) Λ4 specification (210/297 praise) (Please read the notes on the back before filling out this page) Order Ί Announcement 豕 ... 绦 I 42Ί578 ν '. ^ 'Excitatory Formula 5. Explanation of the Invention (12) Settlement of drug resistance and dubicide resistance of shellfish consumer cooperation by the Central Bureau of Standards of the Ministry of Economic Affairs. These compounds all show a low effect. Test compounds: Kalsen (Dicofer), Midine, Ephrametin, and Miococotin all showed high tick killer effects in this experiment. The test compound obtained de-mite and fenocelocarbon showed low wall killing effect in this experiment 3
表II 測試混合物對抗已獲抗氣分那必抗藥性之 堪閘娃蟎雌成蟲的作用評估 lc5〇 測試混合物 比例1 (ppm) 丁 c 氣分那必+三亞蟎 1 ：5 64 370 氣分那必+得脱蛾 1 ：3.2 72 4400 氣分那必+卡爾先 1 ：5.3 34 110 氣分那必+苯異三溴苯酚鹽 1 ：6 97 330 氣分那必+分错赛歐碳 1 ：10 270 380 氣分那必+密定分 4 ：5 4.0 450 氣分那必+愛佛枚可ΐ丁 5 ：1 0.56 140 氣分那必+密歐幣牧可汁 5 ：1 0.75 220 氯分那必+白喊克 1 ：10 150 130 氣分那必+ DPC 5 :12 140 540 氣分那必：第二種活性成份 Te =協同-毒性係數 如表11中所見的數據，每一含氣分那必加上三亞蜗或得 -15- 本紙張適用中國國家標牟（CNS > A4規格（2丨OXW公釐) ~ (請先閱讀背面之注項再填寫本f ) 訂 421578 Λ7 B7五、發明説明（13 )脱蟎或苯異三溴笨酚鹽或分諾赛歐碳或密定分或密歐幣牧 可汀或DPC的測試混合物之協同-毒性係數皆明顯大於 100，其指出強力協同作用。 (請先閲讀背面之注意事項再填^巧本頁)Table II Evaluation of the effect of test mixtures against female adults of Kansas mites that have acquired resistance to qifenapine lc50. Proportion of test mixture 1 (ppm) Dc qifennabi + Sanya mite 1: 5 64 370 qifenna Must + get rid of moth 1: 3.2 72 4400 Qifen Nabi + Karl first 1: 5.3 34 110 Qifen Nabi + Benzisotribromophenate 1: 6 97 330 Qifen Nabi + Miscellaneous Sail Carbon 1: 10 270 380 air cents Nabi + Midine 4: 5 4.0 450 air cents Nabi + Ivory cocoa 5: 1 0.56 140 air cents Nabi + Mimo Muco 5: 1 0.75 220 chlorine Nabi + Bai Chouke 1: 10 150 130 Qi Nabi + DPC 5: 12 140 540 Qi Nabi: the second active ingredient Te = synergistic-toxicity coefficient as shown in Table 11, each gas containing It is necessary to add Sanya snail or get -15- This paper is applicable to Chinese national standard (CNS > A4 size (2 丨 OXW mm) ~ (Please read the note on the back before filling in this f) Order 421578 Λ7 B7 V. Description of the invention (13) The synergy-toxicity coefficients of the test mixtures of acarid or phenylisotribromobenzyl phenoxide or denoseo carbon or midine or meocoin mecotin or DPC are all clear. Greater than 100, it pointed out that a strong synergistic effect. (Please read the Notes on the back ^ clever reloading this page)
、1T ΛI · 經濟部中央標隼局負工消f合作社印製 -16- 本纸張尺度適用中國囤家榡隼（CNS ) A4規格（210X 297公漦）、 1T ΛI · Printed by the Ministry of Economic Affairs, Central Bureau of Standards and Labor, Co-operative Society -16- This paper size is applicable to China Storehouse (CNS) A4 specification (210X 297 public)