五、發明說明（1) 經濟部智慧財產局員工消費合作社印製 發明背景 ，本發明關於液體施配器，尤其關於用於一液體施配器之 十數器，用以指示最近一次施配後經過之時間、完成施配 後存邊於罐體内之施配劑數量、以及在一預定時段中完成 之施配次數。 相關技術簡述 各種之液體施配器己爲人熟知且可購獲而自一容器内施 配—定量比例之内含液體。譬如，美國第3,749,290號專利 説明一種與液體容器組裝之扳機啓動式施配泵浦。一旦啓 動後’ 一定量比例之内含液體被自容器中分配。 用以施配藥理上呈活性之複合物至人類及動物之定量藥 %]及入器做爲液體施配器極爲重要。使用該種定量藥劑吸 入器廣爲人知，同時此一技術已發展25年而涵蓋各種型式 之“泵浦，，型藥物施配器之基本概念。此裝置可爲人工加壓 式（諸如美國第5,284，132號專利所述）或可採用好似循環式 加壓。藥物亦可自一丟棄式壓力罐中重覆釋出，俾視需要 而產生重覆之噴出或吸入。 口腔用及鼻腔用藥物施配之早期代表性吸入器，説明於 諸如美國第 3,361,306、3，1 83,907、3,565,070、4,206,758、 4,803,978、4,934,358 ' 4,955,371、5,060,643 及 5,35 1,683 號 專利。供大型哺乳動物如馬匹使用之代表性鼻咽式吸入 器’説明於美國第5,〇62,423號專利。 定量藥劑吸入器（MDIs)目前爲最有效且最被接受之裝 置’俾精確地輸送小量藥劑之藥物至動物之呼吸系統。通 -4- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） V 裝--------訂---------線 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（、 常藉由吸入路径輸送之治療劑，包含支氣管擴張劑（B 2主 動肌以及抗膽素）、腎上腺類固醇以及抗過敏劑。吸入作 用對抗感染、預防接種、系統性動作及診斷藥劑、以及抗 支氣管收縮、抗蛋白酶以及類似物，亦可為一可靠之路 徑。 MDIs可為多種型式。最常見之MDIs包含一抗壓容器（罐 體），其基本上在一超大氣壓力下，充填諸如溶於液態增 進劑内 < 藥劑，或是懸浮於—液態增進劑内之微小顆粒之 產物。；i器與一定量閥配接。閥件可自一内侧（充填）位置 轉移至一外侧（排放）位置。一偏置彈簧固定閥件於其充填 位置，直到其被強推至排放位置。定量閥之致動，使得罐 體内含物之定量部位被釋出，而液態增進劑運送溶解或微 粒化之藥物顆粒離開容器而進入病體。閥啟動器亦可用以 引導喷霧劑噴塗式地進入病患之口腔咽頭。表面劑通常溶 於喷霧劑配方中，其可擔任雙功能之潤滑閥件及減少微小 顆粒之聚集。 用於定量藥劑吸入器（MDI)之代表性製藥配方，說明於 美國弟5,190,029 5虎專利。此種施配製藥配方之mdi裝置亦 廣為人知，且可見諸於美國第336^3^、3,565,〇7〇及 4,955,371號專利之說明中’其均納入本文供作參考。 使用此種已知裝置之日增缺點’為病患在任何已知時刻 中’無法確知噴霧容器内之藥物存量。容器—般無法透 視’用以保護内含物之受光。搖動將總無法獲悉其内含物 之聽聲訊息。在一極端之狀況下’此可意謂可能遭受嚴重 -5- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -----------^i —-----訂-------線 {請先閱讀背面之注意事項再填寫本頁) A7 A7 經濟部智慧財產局員工消費合作社印製 五、發明說明（3 氣€炎或類似緊急狀況而需要一帖藥劑之病患，將發現 賣務谷器因其已經用罄而無法施配藥帖。此一問題已被認 知且考里而賦予解答。譬如，美國第4,8 17,822號專利說明 種吸入器裝置，其包含一計數裝置，用以指示容器之相 士工置量或疋已施配之藥帖數量。可是，此種吸入器計量 农置’實際上藉由諸如一扣環或固定蓋與噴霧容器以及吸 入器連接。在一實例中，計數裝置為一套接於喷霧容器之 朝上底部之分離式套筒。其易於遣失、無法與吸入器組 〇、且其輔助單元易於滑越鬆弛之喷霧容器。在另—實例 中，計數裝置需緊固於噴霧容器頸部，其將防止容器與吸 入器之分離，縱然空置時亦然。此吸入器裝置僅可用於搭 _己初始之噴霧罐使用卻無法搭配充填式噴霧罐使用。 美國第5,020,527號專利改進了美國第4,8 17,822號專利之 藥帖計數裝置’其中機械式計數器可由電子式計數器取 代。改良之吸入器可指示存留於喷霧容器内之藥帖數量。 可是’此一裝置在操作時無法防愚，其落在極端衰弱、恍 惚或健忍病患手中時可為一缺點。在包含年幼小孩之家庭 中’他們在當疏於照顧時’已知曾以MDIs為玩物。嬰兒 可能意外地重新設定或攪亂機械式裝置之設定好計數。譬 如’計數器可能意外地重新設定、排除其使用性、同時實 際上誤導病患存於容器内之真正藥帖數量。此外，計數器 在當使用一充滿之全新喷霧容器（充填式）時，無法自動地 重新設定。此將影響已完成計數之準確性。 此外，美國第5,〇2〇,527號專利中之吸入器，仍採用機械 -6 - 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ------------^--------訂---------境 (請先閱讀背面之注意事項再填寫本頁) A7 A7 經濟部智慧財產局員工消費合作社印製 * ----B7__ 五、發明說明（4 ) 式扳機致動計數裝置，其將當諸如喷霧容器被移開且吸入 器裝置獨立於喷霧容器之外而清洗及消毒時，遭致啓動計 數态未貫際自容器中施配一帖藥。 美國第5,622,163號專利説明一種用於液體施配器之計數 器’其固定於液體容器末端。一定量藥帖之施配，瞬時啓 動一發光二極體（LED)，俾示訊使用者存留容器内之施配 數量。LED經設定爲200劑而施配180劑後，每次施配後1 〇 秒4里内’每秒閃光兩次。在2 〇 〇劑之施配19 〇劑後，可以聽 到聲響。第2〇〇劑施配後，LED被設定爲長保明亮，直到 電池耗盡或罐體被更換。變通地，可於第2〇〇劑施配後， 連續聽到聲響。雖然美國第5，622,163號專利中説明之計數 器’提供罐體已接近其使用壽限末期之信號予使用者，但 計數器無法指示存留於容器内之實際施配數量。 因此，需要一種用於液體施配器之計數器，其可指示最 近一次施配後經過之時間、存留於罐體内之施配數量、以 及預定時段内冗成之施配次數。使用日期及時間可貯存 於一施配特定式積體電路（ASIC)記憶體内，俾讓Mm可終身 適用於健保人員，用以決定病患之適配性及使用型別。此 一曰期對數個方面之疾病管理甚受重視。 美國第5,622,163號專利中説明之裝置，其計數器頂端包 含一撓性薄片，當被壓縮時，其啓動—微動開關，俾指示 已執行一次施配。微動開關被設定於相較爲3磅之一般壓 力需求時，其可在3至7磅之壓力範園内操作而自容器内施 配液體。錯誤之計數可因非常接近需用以啓動微動開關以 本紙張尺—家標準（CNS)A]規格⑵〇 x 297公釐） * · ------------I · I I-----t.. — — — ,— — 1!·^ (請先閱讀背面之注意事項再填寫本頁) 五、發明說明（5 A7 B7 經濟部智慧財產局員工消費合作社印製 及而用以自液體容器内施配_劑藥乏 * Ρ , 釗柒足壓力而減至最小。只 罟已知需用以啓動微動開關之壓 ,^ ^ ^ 没刀及而用以進行一次施配 疋基本壓力範圍，即可進行一 Μ m 人她配而不需啓動微動開 關’因而導致一次不精確之計數 甘i λ 卄数破動開關易遭磨耗，尤 具由於其可用壽限過程中之疲勞 敗贫向歷耗。雖然微動開關可 ，，莖初始之校正至一特定之啓動赓力，抬田 ' — 力壓力仁用以啓動微動開關 (貫際壓力’可歸重覆使用而增加或減少。因此，計數 器精度、尤其當罐體接近耗盡時，可能被折衷使用。 罐體接近耗盡時，極關鍵者爲計數器仍保精準以防止上 之情況，W 一帖藥劑之患者卻正處於緊急情況下。依 賴需用以啓動微動開關以防止此種錯誤計數之壓力，限制 其多樣性，同時可能增加計數器之成本。此外，藉由依賴 挽性薄片及框體以密封計數器，一旦於一體性之撓性薄片 及/或框體產生破裂時，將使計數器遭致傷害性之外曝 濕氣下。 因此，需要一種用於液體施配器之計數器，其中需用 產生一施配信號之壓力，可儘量接近需用以進行—次施 之壓力’因而終將消除被錯誤計算之施配。進一步地需女 一種用於液體施配器之計數器，其提供增強之保護以對抗 濕氣及其他有害雜質’包含液體容器内有之液體混雜物。 這些及其他與以往技術吸入器及其他液體施配器有關 問題’可藉由稍後説明之本發明加以解決。本發明裝 價經濟且易於搭配液體容器组裝，同時可當容器耗盡 棄，其方式相同於目前之丟棄容器。 8- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 當 述 依 於 以 要 之 置造 時丢 -------------裝--II----訂---------線 (請先閱讀背面之注意事項再填寫本頁) A7 B7 五、發明說明（6 ) 本發明裝置期欲搭配一液體容 盡時與其一併丟棄。人 同寺爾内各物条 新設定計數器。 *因此—程序造成之錯誤而重 發明總論 二:二他：：目標’可根據本發明而藉由提供—用於 用以緊密地將需用以自—液體容動，簧， 力，符合需用以進行一次施配之愚六中不況/ 入犯配之壓 -fm計數11可另外包含 ，公片其1倒裝晶片“型式之套裳件，其固定於—玻 璃溥片之表面上，_裝於-環氧樹脂内以密閉及密封 微晶片，«微晶片免受濕氣以及其他之有害污染物在 本發明裝置適用於維持持續貯存預定數量之液體，俾自 :容器内施配’同時當—預定數目之施配量存留於容器内 “訊。其操作較爲簡易，縱然對幼童(6至12歲)亦炊。 譬如’本發明可讓人們保有存留以量藥劑吸人器内及其 他液體施配器内供用之施配藥劑數量。 經濟部智慧財產局員工消費合作社印製 上述及其他有利目標’可根據本發明而亦藉由提供一用 於液體施配器之計數器獲得，其自動地循序顯示最近一次 施配迄今所經過之時間、存留於容器内之施配數量以及過 去24小時内完成之施配次數，以及在各種記憶體内貯存之 使用時間及日期。 本發明裝置適用於維持持續貯存預定數量之液體，俾自 一容器内施配，同時示訊存留於容器内之實際施配數量。 本發明裝置另外提供最近一次施配迄今所經過之時間以及 -9 - 本纸張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（7 ) #又預疋時間中完成之施配次數以保存記錄，俾確保病患 之配合性，同時協助健忘人們，小孩及其家長及年長人士 持續其治療計畫。一病患使用之存留記錄，可護健保人士 藉由將一傳統SRS 232型連接器與計數器組合而輸入一電 腦中。其操作較爲簡易，縱然對幼童（6至12歲）亦即。譬 如，本發明可讓人們保有存留於定量藥劑吸入器内及其他 液體施配器内供用之施配藥劑數量，同時獲得關於最近施 配之額外數據。 本發明實例將參考附圖説明，其中： 圖1爲一顯示與計量數吸入器噴霧罐組裝之本發明計量 吸入器實例之透視圖。 圖2爲如同圖1之圖式，但配置外加裝置，用以輸入已記 錄 < 使用數據至諸如個人電腦之健保資料電腦。 、圖3-5爲顯示本發明吸入器丨〇裝置3 〇之分段圖式，其循 序展示收集计算且存入i己憶體内使用之數據。圖3顯示 罐子1 6内存留之藥劑數量。圖4顯示過去2 4小時内之使用 量，而圖5顯示前次藥劑之已施用時數。此一資料對許多 諸如氣喘之疾病管理甚爲重要。 圖6爲圖1及2中所示計數裝置之分解圖。 圖7爲圖1中所不總成件1 〇之剖面側視圖，丨進一步描 述實例之結構細節。 圖8爲圖1-6中户斤爵譽罢，Λ、.丨 斤是裝置3 0之剖面側視圖，其已完成使用 以產生一藥劑施配。 圖9爲圖13中所不計數裝置之本實例微電子指示裝置之 .------裝--------訂---------線 (請先閱讀背面之注意事項罗'填寫本頁) -10 A7V. Description of the invention (1) Background of the invention printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economics. The present invention relates to liquid dispensers, and in particular to a ten-piece dispenser for a liquid dispenser, which is used to indicate the passage after the last dispensing Time, the amount of dosing agent stored in the tank after the completion of the dosing, and the number of dosing completed in a predetermined period of time. Brief Description of the Related Art Various liquid dispensers are well known and commercially available and are dispensed from a container—containing a fixed amount of liquid. For example, U.S. Patent No. 3,749,290 describes a trigger-actuated dispensing pump assembled with a liquid container. Once activated 'a certain proportion of the contained liquid is dispensed from the container. It is extremely important to dispense pharmacologically active complexes to human and animal quantitative drugs] and dispensers as liquid dispensers. The use of this metered dose inhaler is widely known, and the technology has been developed for 25 years and covers the basic concept of various types of "pump," type drug dispensers. This device can be manually pressurized (such as US No. 5,284 (Described in Patent No. 132) or cyclic pressurization may be used. The drug may also be repeatedly released from a disposable pressure tank, and repeated spraying or inhalation may be generated as needed. Oral and nasal drug administration Equipped with early representative inhalers, as described in U.S. Patent Nos. 3,361,306, 3,1 83,907, 3,565,070, 4,206,758, 4,803,978, 4,934,358 '4,955,371, 5,060,643, and 5,35 1,683. Representative noses for large mammals such as horses A "pharyngeal inhaler" is described in U.S. Patent No. 5,062,423. Quantitative medicament inhalers (MDIs) are currently the most effective and accepted devices' to accurately deliver small amounts of medicament to the animal's respiratory system. -4- This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) V Pack -------- Order --------- Line (Please read the note on the back first Fill in the items again This page) Printed A7 B7 printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (Therapeutic agents often delivered through the inhalation route, including bronchodilators (B 2 active muscle and anticholin), adrenal steroids and anti- Allergens. Inhalation to fight infections, vaccination, systemic action and diagnostics, and anti-bronchial contraction, anti-protease and the like can also be a reliable path. MDIs can be of many types. The most common MDIs include primary antibodies Pressurized container (tank), which is basically filled with a product such as a pharmaceutical agent dissolved in a liquid enhancer, or a product of fine particles suspended in a liquid enhancer under a super-atmospheric pressure. Valve mating. The valve can be transferred from an inside (filling) position to an outside (discharging) position. A biasing spring holds the valve in its filling position until it is forced to the discharge position. Actuation of the metering valve, The quantitative part of the contents in the tank is released, and the liquid enhancer transports the dissolved or micronized drug particles to leave the container and enter the diseased body. The valve actuator is also It can be used to guide the spray into the patient's oral throat. The surface agent is usually dissolved in the spray formulation, which can serve as a dual-function lubrication valve and reduce the accumulation of fine particles. The representative pharmaceutical formula of MDI) is described in the US patent 5,190,029 5 tiger patent. This MDI device for formulating pharmaceutical formulas is also widely known and can be found in U.S. Patent Nos. 336 ^ 3 ^, 3,565,07,0 and 4,955,371. The description 'which is incorporated herein for reference. The daily disadvantages of using such known devices' is that patients at any given moment' cannot be sure of the drug stock in the spray container. Containers-generally impervious to light 'to protect the contents. Shake will never be able to hear the audio message of its contents. In an extreme situation, 'this may mean that it may be severely affected -5- This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ----------- ^ i — ----- Order ------- Line {Please read the notes on the back before filling this page) A7 A7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Invention Description (3 Qi Yan or similar Patients who need a medicament in an emergency situation will find that the selling device can not be dispensed because it has been used up. This question has been recognized and answered by the test. For example, US No. 4,8 17,822 The patent describes an inhaler device that includes a counting device to indicate the amount of container placement or the number of medicine patches that have been dispensed. However, such an inhaler metering device is actually used, for example, by a buckle The ring or fixed cover is connected to the spray container and the inhaler. In one example, the counting device is a set of separate sleeves attached to the upper bottom of the spray container. It is easy to lose, cannot be connected to the inhaler, and Its auxiliary unit is easy to slip over a loose spray container. In another example, the counting device needs Fastened to the neck of the spray container, it will prevent the container from being separated from the inhaler, even when it is empty. This inhaler device can only be used for the initial spray can, but cannot be used with the filled spray can. Patent No. 5,020,527 improves the US Pat. No. 4,8 17,822 patent counting device 'where the mechanical counter can be replaced by an electronic counter. The improved inhaler can indicate the number of medicinal patches remaining in the spray container. But' this one The device is not foolproof during operation, and it can be a disadvantage when it falls into the hands of extremely debilitated, sick, or tolerant patients. In families containing young children, 'they are neglected when they are neglected', it is known to use MDIs as Playthings. Babies may accidentally reset or disturb the setting of the mechanical device to count. For example, 'the counter may be reset accidentally, excluding its usability, and at the same time actually misleading the actual number of pills in the container. In addition, The counter cannot be reset automatically when using a completely new spray container (filled type). This will affect the accuracy of the completed count In addition, the inhaler in the US Patent No. 5,002,527 is still using a mechanical-6-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ----- ------- ^ -------- Order --------- Environment (Please read the notes on the back before filling out this page) A7 A7 Employee Consumer Cooperatives, Intellectual Property Bureau, Ministry of Economic Affairs Printed * ---- B7__ 5. Description of the Invention (4) A trigger-actuated counting device will be damaged when, for example, the spray container is removed and the inhaler device is cleaned and disinfected independently of the spray container. The start counting state has not been followed by dispensing a patch from the container. US Patent No. 5,622,163 describes a counter for a liquid dispenser, which is fixed at the end of the liquid container. A certain amount of medicine is dispensed, and a light emitting diode (LED) is instantaneously activated to indicate the amount of dispensed in the container. After the LED is set to 200 doses and 180 doses are dispensed, the LED blinks twice every 10 seconds within 10 seconds after each dispensing. After administering 200 doses of 200 doses, a sound can be heard. After the 200th dose, the LED is set to stay bright until the battery is exhausted or the can is replaced. Alternatively, the sound can be heard continuously after the 200th dose. Although the counter described in U.S. Patent No. 5,622,163 provides a signal to the user that the tank is approaching the end of its useful life, the counter cannot indicate the actual amount dispensed in the container. Therefore, there is a need for a counter for a liquid dispenser that can indicate the time elapsed since the last dispensing, the number of dispensings remaining in the tank, and the number of redundant dispensings within a predetermined period. The date and time of use can be stored in a special integrated circuit (ASIC) memory, allowing Mm to be used for life for health care personnel, to determine the patient's suitability and type of use. This session has paid much attention to disease management in several aspects. The device described in U.S. Patent No. 5,622,163 includes a flexible sheet at the top of the counter which, when compressed, activates a micro-switch to indicate that a dispensing has been performed. When the micro switch is set to a general pressure requirement of 3 pounds, it can be operated in a pressure range of 3 to 7 pounds to dispense liquid from the container. The count of errors can be very close to the micro-switch required to activate the paper rule—CNS A] specification ⑵〇x 297 mm) * · ------------ I · I I ----- t .. — — —, — — 1! · ^ (Please read the precautions on the back before filling out this page) V. Description of the invention (5 A7 B7 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs And it is used to dispense medicine from the liquid container. * P, to minimize the pressure. Only the pressure required to activate the micro-switch is known. ^ ^ ^ No knife and used for once Applying the basic pressure range, you can carry out one Mm person without the need to activate the micro-switch. This results in an inaccurate counting. Λ 卄 Number-breaking switch is easy to wear, especially due to its useful life Fatigue from fatigue to poverty is consumed. Although the micro-switch is available, the initial correction of the stem to a specific starting force, lifting the field '— the force pressure is used to activate the micro-switch (international pressure' can be used repeatedly and Increase or decrease. Therefore, the accuracy of the counter, especially when the tank is almost exhausted, may be compromised. When it is nearly exhausted, the key is to keep the counter accurate to prevent the above situation, but the patient with a medicine is in an emergency. Relying on the pressure needed to activate the micro-switch to prevent this wrong counting, limit its Diversity at the same time may increase the cost of the counter. In addition, by relying on the sheet and the frame to seal the counter, once the integrated flexible sheet and / or frame is broken, the counter will be harmed. It is exposed to moisture. Therefore, a counter for a liquid dispenser is needed, in which the pressure for generating a dispensing signal is required, which can be as close as possible to the pressure required for the "second application", so it will eventually eliminate erroneous calculations. Dispensing. There is further a need for a counter for liquid dispensers that provides enhanced protection against moisture and other harmful impurities' contains liquid contamination contained in liquid containers. These and others are similar to prior art inhalers and others The problems related to the liquid dispenser can be solved by the present invention described later. The present invention is economical to install and easy to assemble with a liquid container At the same time, when the container is exhausted, the method is the same as the current disposable container. 8- This paper size is applicable to the Chinese National Standard (CNS) A4 (210 X 297 mm). ------------ Installation--II ---- Order --------- Line (Please read the precautions on the back before filling this page) A7 B7 V. Description of the invention (6) The device of the present invention is intended to be discarded with a liquid when it is used up. A new counter is set for each item in Rentong Temple. * Therefore—the error caused by the program is reinvented. 'Can be provided in accordance with the present invention-for tightly applying the self-liquid fluid, spring, force, in accordance with the present invention, in order to perform a single dispensation of the six unconditional / pressure of invasion- The fm count 11 may additionally include a male piece of a 1-chip flip chip type, which is fixed on the surface of a glass cymbal, _ mounted in an epoxy resin to seal and seal the microchip, «microchip Protected from moisture and other harmful pollutants The device of the present invention is suitable for maintaining continuous storage of a predetermined amount of liquid. 'At the same time when - dispensing a predetermined amount of the number of remaining in the container "inquiry. Its operation is relatively simple, even for young children (6 to 12 years old). For example, the present invention allows one to keep a quantity of the dispensed medicine available in the inhaler and other liquid dispensers. The above-mentioned and other favorable targets are printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs, which can be obtained according to the present invention and also by providing a counter for liquid dispensers, which automatically and sequentially displays the time elapsed since the last dispensing, The number of doses stored in the container, the number of doses completed in the past 24 hours, and the time and date of storage in various memories. The device of the present invention is suitable for maintaining a continuous storage of a predetermined amount of liquid, which is dispensed from a container while indicating the actual dispensed amount remaining in the container. The device of the present invention additionally provides the time elapsed since the last dispensing and -9-This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 B7 V. Description of the invention (7) #The number of dispensations completed during the time is recorded in advance to keep records to ensure the compatibility of patients, and to help forgetful people, children and their parents and seniors to continue their treatment plans. Retention records used by a patient can be entered into a computer by a healthcare provider by combining a traditional SRS 232 connector with a counter. Its operation is relatively simple, even for young children (6 to 12 years old). For example, the present invention allows people to keep the quantity of the medicament available in a metered dose inhaler and other liquid dispensers, while obtaining additional data on recent dispenses. An example of the present invention will be described with reference to the accompanying drawings, in which: FIG. 1 is a perspective view showing an example of the metered-dose inhaler of the present invention assembled with a metered-dose inhaler spray can. Fig. 2 is the same as that of Fig. 1, but equipped with an additional device for inputting the recorded < use data to a health insurance data computer such as a personal computer. Figures 3-5 are segmented diagrams showing the inhaler device 〇 of the present invention, which sequentially displays the data collected for calculation and stored in the body. Figure 3 shows the amount of medicament stored in the jar 16. Figure 4 shows the amount used in the past 24 hours, and Figure 5 shows the number of hours the previous dose has been applied. This information is important for the management of many diseases such as asthma. Fig. 6 is an exploded view of the counting device shown in Figs. FIG. 7 is a cross-sectional side view of the assembly 10 shown in FIG. 1, and further details of the structure of the example are described. Figure 8 shows the household reputation in Figure 1-6. Λ,. 丨 is a cross-sectional side view of device 30, which has been used to produce a medicament. Fig. 9 is the microelectronic indicating device of the example not counting device in Fig. 13 .-------------------------------- Order the line (please read the back first) (Notes to fill in this page) -10 A7
五、發明說明（8 ) 底視平面圖。 圖10爲圖6中所示微電子指示裝置之上視平面圖。 圖1 1爲圖9-10中所示微電子裝置之本實例電路構架之底 視平面圖。 一 圖1 2爲圖1 1中所示電路構架之側視立面圖。 圖1 3爲圖9-1〇中所示微電子指示裝置之本實例微電子電 路元件之概圖。 ％ 圖14爲一與流體容器頸部相連之泵浦侧剖面視圖，其取 自美國第3,749,290號專利之圖9而納入本文供作參考，同 時經修改而與本發明圖M3中所示之裝置組合。 本發明較佳實例之詳細説明 通曉本技術者將可自閱讀較佳實例之下述説明及搭配圖 1-14附圖之圖式而了解本發明，其中每一圖式中之同一數 字，表示相同元件。 圖1爲本發明實例總成丨〇之透視圖，其包含一兩端開口 足中2管件12而與一上置本發明計數裝置30之噴霧罐16 組裝。總成件1 〇爲一計量吸入器（MDI)，其如以往技術中 所知爲傳統式，但因加入裝置3 〇而改良，其包含一微電子 裝置，用以告之來自罐體丨6之施配，計算存留罐體丨6内 l施配數量、指示存留施配劑之計得數量以及其他功能。 圖2爲類同圖丨之圖式，但其圖丨中之實例與插座連接裝 置31組合，用以將收集之病人使用數據輸至個人電腦或其 他數據處理裝置。 圖3-5爲圖丨中所示總成件1 〇之分段圖式，僅包含計數裝 -11 - 本...氏張尺度適用中國國家標準（CNs)A4規格⑵Q χ 297公爱） ------------ - 震---1!訂 -------線 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 五、發明說明（9 A7 B7 經濟部智慧財產局員工消費合作社印製 置3 〇及多數個由微電子裝置控制之連續顯示； 所示’第-次顯示爲存留於罐體1 6内之藥Z .:。如圖3 又弟二’人後續顯示爲過去2 4小時内施配 τ 中夕駐-叔 又樂劑數量。圖5 〒义顯1F數目，亦即前次藥劑施配迄今之時數 H J =在參考圖6,顯示計數裝置30之分解圖式。，並 祖3 2 ’微電子指示器裝置4 〇以發泡彈簧4 2。 匡 裝置30之框體32最好用一透明或半透明之人士 料製作，其形似一倒置之杯體。用以製作計數=二樹1曰材 :合成聚合樹脂材料具透光性’俾當置於—内部 /源時，其仍可發光且照亮附近區域。裝置3 〇之 砰 塗敷於其内部表面（未圖示於圖6中），俾 " 在内部反射或擴散光線。 俾^要選擇性地 用以模製計數裝置30框體32之代表性合成聚合樹脂， 計有熱塑性聚石臘、聚脲脂、聚碳酸物以及聚（甲基 烯），尤其爲那些具半硬體且具有相同撓性之材料，二2 稍後所述地便於安裝及操作。框體32包含一成形於其上0 面之透明鏡片34。鏡片34可與框體32一體成型，或爲 固定於框體3 2輔助開口内之分離元件。鏡片3 4可爲任 尺寸及形&，俾視需要產生—觀視口，用以觀察顯示資料 4 6及用以放大顯示資料4 6。 框體3 2内邵之造形，可用以承置微電子指示器裝置… 發泡彈簧4 2以及連附於罐體丨6之軸襯。微電子指示器裝 置？在圖6中以概略長方形元件顯示，但宜了解微電子指 示器裝置可爲任何適當之形態。一輔助前室48界定於框 表 何 體 I---------jtr--------- f請先閲讀背面之注意事項再填寫本頁) -12- 本紙張尺度適用中關家標準（CNS)A4^^X 297 — ΚΙ Β7 經濟部智慧財產局員工消費合作社印製 6 五、發明說明（10 ) 32内，用以承置微電子指示器裝置4〇。微電子指示器裝 置40相對於框體32之旋轉，受制於微電子指示器裝置4〇 之長方形狀，因而確保微電子指示器裝置4 〇相對於鏡片 3 4之適當方位。雖然微電子指示器裝置4 〇可爲任何形 悲，但選用之特定形態，必須防止微電子指示器裝置4 〇相 對於框體3 2及鏡片3 4之相對旋轉。 一後室50(見圖7)界定於框體32内，用以承置發泡彈簧 42及抽襯44。當發泡彈簧42及軸襯44安裝於框體32内 時’發泡彈黃4 2被置於軸襯4 4上表面内之輔助袋體5 2 中’而發泡彈簧42之上表面，鄰貼微電子指示器裝置4〇 之下表面。如上所述之框體32，最好由一聚合樹脂構成。 聚合樹脂材料具有先天之恢復力，其可提供恢復力至垂片 3 6上。當將軸襯4 4與框體3 2組裝時，一面向軸襯4 4側壁 滑動之掣3 8 (見圖7 )子斜面部位，推使垂片3 6徑向地向外 移動，增加框體3 2開口之有效外徑。一旦軸襯4 4完全定 位於框體3 2内時，垂片3 6被徑向地向内推動，使得掣子 3 8之平滑上表面，保持與軸襯4 4側壁之下表面接觸，因 而固定軸襯44於框體32内。 如圖7所示，其爲本發明吸入器總成1 〇實例之剖面側視 圖。吸入器總成基本上爲一具有一第一開口端14之中空管 1 2，其大小及形態適可承置一組裝好之噴霧罐1 6。一小 通氣孔13可於使用過程中，連通管件12之中空部位20， 容許外界空氣進入計量藥劑吸入器1 0之内部。噴霧罐1 與一傳統之計量閥（未圖示）及一噴桿1 8配合。此種罐體可 -13- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------·-------------I 111----^ (請先閱讀背面之注意事項/填寫本頁) 經濟部智慧財產局員工消費合作社印製 A7 B7_ 五、發明說明（y 購自美國北卡州之Bespak公司，同時可内含任何傳統上用 於諸如美國第5,190,029號專利中所述之口用及鼻用藥物之 配藥。組裝好之管件12及罐體，將罐體16部分地置入 管件12之中空部位20。開口端22與中空部位2〇相通，其 大小及形態適可形成一 口銜件，用以插入病患口腔，同時 連接或密封地接合嘴唇，供給哺乳動物之吸入及呼出。開 口端22可變通地用以接合病患之鼻腔。中空部位2〇内^ 固一喷劑定向元件2 3，其内含一連續性之内部導管2 4 ^ 導管24與喷霧罐16之样件18連接，其當罐體“被使用者 下壓時’將一計量好之藥劑噴嘴26噴向管件12之開口端 22。罐體16閥件在當使用者壓下罐體16時釋出量Z 之藥劑’推使桿件18靠向元件23。在本發明之較佳^例 中’管件12在開口端14外以及其徑向内侧之内壁，可緊 貼罐體16之外（滑動接合），使得罐體可自由地:中空部 位2 0内移動，直到捍件1 8被元件2 3止動方止，作其足^ 地緊贴以防止噴霧於使用過程中，經由開口端丨4逸出 在圖1及圖2中同時概示經由開口端i 4而滑動接合於中介 部位20内之向上轉動之罐體16，可被下壓至元件上二 當被壓至元件23上時，罐體16上之閥件開啟而釋出—帖二 狀藥劑，其經由捍件1 8及導管2 4自噴嘴2 6噴向管件^狳 開口端22。每次當其被完全地壓向元件23時，—12〈 帖藥劑ή 噴務罐1 6釋出。噴霧罐丨6上之壓力釋出， 貝翁^ 1 6 復至其未被壓下位置，同時當閥件再被啟動 、 , 寸，充填關 件而另一次之藥劑排出。如圖7所示，閥件密封於罐俨3 -14- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -------------f^i--1---訂---------嘴' (請先閱讀背面之注意事項再填寫本頁) A7 B7 五 發明說明（12) 其當桿作18在内部壓入罐體16時作用。閥件本 身t圖：於圖〗、2或6、7中，其爲傳統式，同時置入罐體 1 6本身之容器内。 -密封計數裝置30與罐體16之_體成型，其黏附且血 法與罐體16朝上時底部位置處之罐體外部相互移動，用以 在每次啓用且釋出-帖藥劑後，確定存留罐體i 6内之藥劑 數量。罐體16朝上時底部處之計數裝置3〇定位，可讓使 用者如上所述地藉由手指壓下計數襞置30框體32而壓縮 雒體16。密封計數裝置3〇框體32内之微電子計數裝置 4〇 ’將可如稍後更詳述般地容許使用者在任何時刻移去罐 體16、連附計數裝置30以水、肥i、消毒劑及防腐劑清洗 管件12而不會傷害或干擾進行中之計數。一種較佳之黏劑 爲氰丙晞酸黏劑。此點甚爲重要，因爲許多噴霧處方之噴 灑，會留下黏性之殘劑，其將黏著灰塵及穢物顆粒。某些 黏提供媒介供不期望微生物之成長。如果這些微生物之成 長不被察覺，其將成爲病患之感染源，同時經常將病原引 入病患之呼吸系統。 再如圖7所示，發泡彈簧4 2 —般呈圓環形。發泡彈簧4 2 由發泡彈性體製作’其具有開啓或封閉之小室結構。發泡 彈簧4 2最好由具有一封閉小室結構之發泡丁烯橡膠製作， 然而其他諸如聚脲脂彈性體或聚氣乙烯材料亦可使用。發 泡彈簧4 2製作成具有某種壓縮強度及回彈性，俾獲得預期 之啓動壓力（3至7磅）以壓縮發泡彈簧42 ,同時將如稍後 所述地啓動微電子指示器裝置4 0。當與框體3 2組裝時， -15- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） — III —II I I I I--訂 — — — — — —--- (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 A7 B7 五、發明說明（13) 發泡彈簧42略被壓縮至後室50内，俾與前室48產生緊密 之流動密封，因而將微電子指示器裝置40密封於框體32 内。如圖7所示，軸襯44具有一凹袋54，適可承置罐體16 之朝上底面，同時以氰丙缔酸黏劑黏固其上。 發泡彈簧4 2在手指壓力下可確保開關觸片6 2被壓縮而 與開關軟墊6 8 (見圖7-8)接觸，俾如稍後敘述地記綠一次 施用。 圖8爲一如圖7所示之計數裝置30圖式，但其計數裝置 3 0已被壓下而藉由開關6 2與開關軟墊6 8之閉合而產生~ 次計數。 圖9爲一微電子指示器裝置40實例之底視圖。微電子指 示器裝置40包含一顯示器46裝於其上之電路板60(見圖7-8)。顯示器4 6最好爲液晶顯示器（LCD)，其可顯示至少三 位數字。宜了解可由顯示器4 6顯示之數字數目，必須相等 於容器16内施用量額度。LCD裝置已廣爲人知，其可爲諸 如美國第4,804,953、5,227,899以及5,227,901號專利中之型 式。微電子指示器裝置4 0包含記憶體及定時器部分，用以 記錄施配時間，同時此種記錄之數據可經由配接蓋3 1而藉 由端子94(見圖1及2)記錄或傳送至一電腦或其他儀器内 供分析之用’同時確保病患遵照一治療計畫。微電子指示 器裝置40可另外包含一聲響警示，其可當諸如完成罐内 1 6之前一次施配時，聽到聲響警示。變通地，當存留於罐 體16内之施配數量低於預定數量或是低於整個罐體16内 施配數量之諸如1 〇%之預定百分比時，亦可聽到聲響警 -16- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公爱） ----------------- f請先閱讀背面之注意事項再填寫本頁) I · "線· A75. Description of the invention (8) Bottom plan view. FIG. 10 is a top plan view of the microelectronic pointing device shown in FIG. 6. Fig. 11 is a bottom plan view of the circuit structure of the microelectronic device shown in Figs. 9-10 in this example. A FIG. 12 is a side elevation view of the circuit structure shown in FIG. 11. Fig. 13 is a schematic diagram of the microelectronic circuit element of the present example of the microelectronic indicating device shown in Fig. 9-10. 14 is a cross-sectional side view of a pump connected to the neck of a fluid container, which is taken from FIG. 9 of U.S. Patent No. 3,749,290 and incorporated herein by reference, and is modified to correspond to the device shown in FIG. M3 of the present invention combination. Detailed description of the preferred embodiment of the present invention. Those skilled in the art will understand the present invention by reading the following description of the preferred embodiment and the accompanying drawings of Figures 1-14. The same number in each figure represents Same components. FIG. 1 is a perspective view of an example assembly of the present invention, which includes an opening at both ends and two tube pieces 12 in the foot and is assembled with a spray can 16 on which the counting device 30 of the present invention is placed. The assembly 10 is a metered-dose inhaler (MDI), which is known as conventional in the prior art, but improved by adding a device 30, which includes a microelectronic device to inform it from the tank. 6 For dispensing, calculate the amount of l to be stored in the storage tank, indicate the amount of remaining dosing agent, and other functions. Figure 2 is a diagram similar to Figure 丨, but the example in Figure 丨 is combined with the socket connection device 31 to input collected patient use data to a personal computer or other data processing device. Figure 3-5 is a segmented diagram of the assembly 10 shown in Figure 丨, including only counting devices -11-This ... The Zhang scale is applicable to Chinese National Standards (CNs) A4 specifications ⑵Q χ 297 public love) -------------Earthquake --- 1! Order ------- Line (Please read the notes on the back before filling out this page) System 5. Description of the invention (9 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs and printed by 30 and most of the continuous displays controlled by microelectronic devices; the '-time display shown' is stored in the tank 16 Medicine Z.:. Figure 3 shows that the younger two people's follow-up shows the number of τ Zhong Xi Zhu-Shu Le Yue dosed in the past 24 hours. Figure 5 Yi Yi Xian 1 F number, that is, the previous dose of medicine so far Hours HJ = In reference to FIG. 6, the exploded view of the counting device 30 is shown, and the 3 32 'microelectronic indicator device 4 0 with a foam spring 4 2. The frame 32 of the Kuang device 30 preferably uses one Made of transparent or translucent materials, it looks like an inverted cup. It is used to make counts = two trees and one material: synthetic polymer resin material is translucent. 'When placed in-inside / source It can still illuminate and illuminate the nearby area. The device 30 is applied to its internal surface (not shown in Figure 6), and "reflects or diffuses light inside." ^^ To be selectively used to model Representative synthetic polymer resins for the frame 32 of the counting device 30, including thermoplastic polyparaffin, polyurea, polycarbonate and poly (methene), especially those with semi-hard body and the same flexibility 2, 2 is described later for easy installation and operation. The frame body 32 includes a transparent lens 34 formed on the 0 side. The lens 34 may be integrally formed with the frame body 32 or fixed in the auxiliary opening of the frame body 32. The separation element. The lens 3 4 can be of any size and shape, and can be generated as needed—viewing viewport for observing the display data 4 6 and for enlarging the display data 4 6. The shape of the frame 3 2 inside Shao, Can be used to house the microelectronic indicator device ... Foam spring 42 and the bushing attached to the tank 丨 6. The microelectronic indicator device? It is shown as a rough rectangular element in Figure 6, but it is better to understand the microelectronic indicator The device may be in any suitable form. An auxiliary anterior chamber 48 is defined in How to display I --------- jtr --------- f Please read the notes on the back before filling out this page) -12- This paper size applies the Zhongguanjia Standard (CNS) A4 ^^ X 297 — ΚΙ Β7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 6 V. Invention Description (10) 32, used to house the microelectronic indicator device 40. The rotation of the microelectronic indicator device 40 with respect to the frame body 32 is restricted by the rectangular shape of the microelectronic indicator device 40, thereby ensuring an appropriate orientation of the microelectronic indicator device 40 with respect to the lens 34. Although the microelectronic indicator device 40 can be of any shape, it is necessary to prevent the relative rotation of the microelectronic indicator device 40 relative to the frame 32 and the lens 34 in a specific form. A rear chamber 50 (see Fig. 7) is defined in the frame body 32 for receiving the foam spring 42 and the pumping lining 44. When the foam spring 42 and the bushing 44 are installed in the frame body 32, 'foam spring yellow 4 2 is placed in the auxiliary bag body 5 2 in the upper surface of the bushing 4 4' and the upper surface of the foam spring 42, Adjacent to the lower surface of the microelectronic indicator device 40. The frame body 32 as described above is preferably made of a polymer resin. The polymer resin material has innate restoring power, which can provide restoring power to the tabs 36. When the bushing 4 4 is assembled with the frame body 3 2, a sliding part 38 (see FIG. 7) facing the side wall of the bushing 4 4 pushes the tab 36 to move radially outward to increase the frame. The effective outer diameter of the body 3 2 opening. Once the bushing 4 4 is completely positioned in the frame body 3 2, the tab 36 is pushed radially inward, so that the smooth upper surface of the catch 38 is kept in contact with the lower surface of the side wall of the bushing 4 4. The fixed bushing 44 is inside the frame body 32. As shown in Fig. 7, it is a sectional side view of an example of an inhaler assembly 10 according to the present invention. The inhaler assembly is basically a hollow tube 12 having a first open end 14 and is sized and shaped to accommodate an assembled spray can 16. A small vent hole 13 can communicate with the hollow portion 20 of the pipe member 12 during use, allowing outside air to enter the inside of the metered dose inhaler 10. The spray tank 1 cooperates with a conventional metering valve (not shown) and a spray rod 18. This kind of tank can be -13- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ------- · ------------- I 111 ---- ^ (Please read the notes on the back / fill this page first) A7 B7 printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs V. Description of the invention (y purchased from Bespak Company, North Carolina, USA, it can also contain Any traditionally used for the formulation of oral and nasal drugs such as described in U.S. Patent No. 5,190,029. The assembled pipe fitting 12 and the can body, the can body 16 is partially inserted into the hollow portion 20 of the pipe fitting 12. Open end 22 communicates with the hollow part 20, and its size and shape can form a mouthpiece for inserting into the patient's mouth, and at the same time connect or seal the lips for the inhalation and exhalation of mammals. The open end 22 can be used flexibly. The nasal cavity of the patient is connected. A hollow directional element 23 is fixed in the hollow part 20, which contains a continuous internal conduit 2 4 ^ The conduit 24 is connected to the sample 18 of the spray tank 16 and acts as the tank body. "When pressed by the user ', spray a metered medicament nozzle 26 toward the open end 22 of the tube 12. The tank 16 valve The amount of medicament released when the user depresses the tank 16 'pushes the rod 18 against the element 23. In a preferred embodiment of the present invention, the' tube 12 is outside the open end 14 and radially inward. The inner wall can be close to the outside of the tank body 16 (sliding joint), so that the tank body can move freely: the hollow part 20 moves inside until the defending part 18 is stopped by the element 2 3, making it close enough In order to prevent the spray from escaping through the open end 丨 4 during use, the upwardly rotating tank 16 which is slidably engaged in the intermediary part 20 through the open end i 4 is schematically shown in Figs. To the upper part of the element, when it is pressed onto the element 23, the valve on the tank 16 is opened and released—the two-shaped medicament is sprayed from the nozzle 26 to the pipe via the guard 18 and the duct 2 4 End 22. Each time when it is fully pressed against the element 23, -12 <the medicine sprayer spray tank 16 is released. The pressure on the spray tank 丨 6 is released, Beyon ^ 1 6 is restored Press down the position, and when the valve is activated again, the valve is filled with the valve and the other medicine is discharged. As shown in Figure 7, the valve is sealed in the tank. 3 -14- This paper Degree applies to China National Standard (CNS) A4 specification (210 X 297 mm) ------------- f ^ i--1 --- Order --------- mouth '(Please read the precautions on the back before filling out this page) A7 B7 Five invention descriptions (12) It acts when the lever 18 is pressed into the tank 16 internally. The valve itself is shown in the figure: 2 or 6 In 7 and 7, it is the traditional type, and it is placed in the container of the tank body 16 at the same time.-The sealed counting device 30 is formed with the body of the tank body 16, which is adhered and the blood method is at the bottom position when the tank body 16 faces upward The outside of the can body is moved to each other to determine the quantity of the medicine in the can body i 6 after each activation and release of the medicine. Positioning of the counting device 30 at the bottom when the can body 16 is facing up allows the user to compress the carcass 16 by pressing the counting unit 30 frame 32 with the fingers as described above. The microelectronic counting device 40 'inside the sealed counting device 30 frame 32 will allow the user to remove the tank 16, the attached counting device 30 with water, fertilizer i, Disinfectants and preservatives clean the pipe 12 without harming or disturbing the counting in progress. A preferred adhesive is cyanuric acid adhesive. This is important because many spray formulations will leave sticky residues that will stick to dust and dirt particles. Some slimes provide a medium for the growth of unwanted microorganisms. If the growth of these microorganisms is not detected, they will become the source of infection for the patient, and the pathogen will often be introduced into the patient's respiratory system. As shown in FIG. 7, the foam spring 4 2 is generally circular. The foam spring 4 2 is made of a foamed elastomer which has an open or closed cell structure. The foam spring 42 is preferably made of a foamed butene rubber having a closed cell structure. However, other materials such as a polyurea elastomer or a polyethylene gas may be used. The foam spring 4 2 is made to have a certain compression strength and resilience, and the expected starting pressure (3 to 7 pounds) is obtained to compress the foam spring 42, and the microelectronic indicator device 4 will be activated as described later 0. When assembled with the frame 3 2 -15- This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) — III —II III I--Order — — — — — — --- (( Please read the precautions on the back before filling out this page) Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs and printed by the Consumers ’Cooperatives of the Ministry of Economics and Intellectual Property Bureau printed by A7 B7 Inside the chamber 50, the grate and the front chamber 48 create a tight flow seal, thereby sealing the microelectronic indicator device 40 in the frame body 32. As shown in FIG. 7, the bushing 44 has a concave bag 54 adapted to receive the upper bottom surface of the can body 16, and at the same time, it is fixed with a cyanoacrylic acid adhesive. Under the pressure of the finger, the foam spring 4 2 can ensure that the switch contact piece 6 2 is compressed and comes into contact with the switch pad 6 8 (see Fig. 7-8), and the green application is recorded once as described later. FIG. 8 is a diagram of a counting device 30 as shown in FIG. 7, but the counting device 30 has been depressed to generate ~ counts by closing the switch 62 and the switch cushion 68. FIG. 9 is a bottom view of an example of a microelectronic indicator device 40. FIG. The microelectronic indicator device 40 includes a circuit board 60 on which a display 46 is mounted (see Figs. 7-8). The display 46 is preferably a liquid crystal display (LCD), which can display at least three digits. It should be understood that the number of digits that can be displayed on the display 46 must be equal to the amount of application in the container 16. LCD devices are well known and can be of the type described in U.S. Patent Nos. 4,804,953, 5,227,899, and 5,227,901. The microelectronic indicator device 40 includes a memory and a timer to record the dispensing time. At the same time, the recorded data can be recorded or transmitted through the terminal cover 31 (see Figures 1 and 2) through the matching cover 31. To a computer or other device for analysis' while ensuring that the patient complies with a treatment plan. The microelectronic indicator device 40 may additionally include an audible alert, which may be heard when, for example, the previous dispensing in the tank 16 is completed. Alternatively, when the amount of dispensing remaining in the tank 16 is lower than a predetermined amount or lower than a predetermined percentage such as 10% of the total dispensing amount in the tank 16, an audible alarm may also be heard. 16- This paper Standards apply to China National Standard (CNS) A4 specifications (210 X 297 public love) ----------------- f Please read the notes on the back before filling this page) I · " Line · A7
請 先 閲 讀 背 © 之 注 意 事 項 再 填 ， I裝Please read the notes of the back © before filling in, I install
頁I 訂 A7 B7 五、發明說明（1S) 套件，其爲人熟知且爲傳統式，而其端予以一熟化之導接 合劑或環氧樹脂固合於個別之軌跡74上。導電接合劑或環 氧樹脂爲可由紫外線熟化之型式。 如圖12所示，電路板60爲多層式玻璃板，其在觀看側 上具有一擴散器80，同時在擴散器對面爲一反射器82 ^ 軌跡74(見圖11)位於配線圖表面84。當電池η裝置於電 路板60之反射器側時，一導電之環氧樹脂72被塗敷於兩 層間，同時在電池軟墊7 〇及配線圖表面8 4間呈電性連 接，一層未圖示之透明紫外光熟化液態環氧樹脂或其他密 封劑’可施加至配線圖表面84以蓋住軌跡74及ASIC 76, 同時經熟化以密封軌跡74及ASIC 76，保護軌跡74&ASIC 76避免受潮及其他污染物之污染。 廷路板60最好用兩層玻璃製作，每層厚度大約爲1丨釐 米’而軌跡7 4由一導電墨水形成而施塗至配線圖表面 8 4。反射器8 2可以反光，同時提供反射光線以適當地成 像液晶顯示器4 6之數字。 一施配特積體電路（ASIC) 76固定於電路板60上且由電池 5 8供電’其諸如一邏輯排列或微處理機，用以處理來自開 關6 2之電性信號，同時啓動液晶顯示器4 6而產生一存留 於容器16内之施配數量之數字讀數。aSIC 76爲一控制裝 置’同時可爲一數値積體電路，擔任其内計數之控制功 能’包含記憶、定時以及上述之通訊功能。如果ASIC 76包 含上述之記憶及定時功能，則ASIC 76可經設定而促使顯 不器4 6顯示該外加參數，譬如最近一次施配之日期及時 -18 - 本紙張尺度洲+咖家標準（CNS)A4規格⑽x 297公髮） -----*---rl —---裝--- (請先閱讀背面之注意事項"填寫本頁) . •線· 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 A7 . —______B7_____ 五、發明說明（16) 間、最近一次施配後經過之時間、以及最近2 4小時内之一 預定時段過程中之施配次數。ASIC 76可進一步地設定而 促使顯示器4 6於每次施配後’順序地顯示外加之參數，或 是重複地經由參數循環。 圖13爲一概示平面圖，顯示電路裝置實例而用於上述之 微電子指示器裝置40。ASIC 76可在製造時賦予程式，俾 於每次使用裝好之裝置後，感測及計算存留於罐體1 6内之 藥劑預定數量。譬如當一充滿之罐體丨6插入吸入器總成 1〇 ’其計數裝置30連附及固定於罐體16、且罐體16之朝 上底面被壓縮而自罐體1 6中產生一劑計量好之藥劑之首次 輸送時，ASIC 76將開始其計數過程。在正常使用過程 中，罐體1 6可於任何時刻與裝置3 〇 一起移開，用以清洗 吸入器總成1 0 ’接著在不改變進行中之計數中置回。 ASIC 76可在製造過程中設定爲諸如2〇〇劑量之總計數。 每次病患壓縮藥罐1 6以獲取一諸如Albuter〇i®之吸入式藥 劑時’發泡彈簧4 2被向下指壓框體3 2之上表面而被壓 縮’同時框體3 2向内滑至朝上罐體丨6之底部。供應足夠 壓力以克服發泡彈簧4 2之阻抗，將使得開關觸片6 2靠向 開關軟墊6 8。開關墊片6 2之封合，啓動微電子指示器裝 置4 0自現有數値中減“一”。在每次施藥後，顯示器4 6顯 π存留於罐體1 6内之藥劑數量。此一可見信號指示存留罐 體1 6内之貫際藥劑數量，同時提供罐體丨6接近用罄狀況 時之指示。 藉由計數裝置3 0之建造以及發泡彈簧4 2之有形態以提 -19- 本紙張尺度 t關家標準（CNS)aI^各（210 X 297公爱）_ -------：------裝--------訂---------線 (請先閱讀背面之注意事項寫本頁) A7 開 設 力 俾 次 五、發明說明（17) 供預設之阻抗以啓動計數，人們可確保在譬如當攜帶 件ίο時，不會造成錯誤之計數。發泡彈簧42可藉由柄;料 之選擇而改變内及外徑及厚度以獲得諸如4至5磅之壓力以 閉合開關觸片62(見圖7-8)，其中自MDI派送一帖藥劑之栌 準壓力大約爲3碲。藉由相近地符合需用以關閉開關觸^ 6 2之壓力，同時自谷器1 6内派送—帖藥劑時，錯誤之計 數可減至最少，同時確保每次施配均適當地反應於計數 上。 圖14爲裝於容器16a上之扳機啓動施配器泵浦1〇&之剖面 側視立面圖（片斷圖示）。容器16a不必需爲透明體，使得 人們興法目視決其内含量。各方面均與上述裝置3 〇相同之 裝置3〇a，黏固至扳機17a上以啓動泵浦l〇a。當扳機被 操作者手指拉動時，一指頭置於框體32a頂端，其經由 關觸片62啓動上述之ASIC 76。如前所示，裝置3〇a内可 置一發泡彈簧42，其以一概略在大約3至1〇磅之預定壓 内作用，此一壓力極接近需用以進行一次施配之壓力， 於扳機17a之操作過程中防止錯誤之計數，同時確保每 施配均納入計數中。 因此，數種前述之目標及優點均幾乎有效地獲致。雖 已發表本發明之單一較佳實例且詳細在此説明，但宜了 本發明決未受其限制，而其範圍將由隨附之申請專利範 決定。 -20- X 2耵公釐） --------------裝--------訂---------線 (請先閲讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 解 圍Page I order A7 B7 5. Description of the invention (1S) kit, which is well-known and traditional, and a cured guide adhesive or epoxy resin is fixed on the individual track 74 at the end. The conductive adhesive or epoxy resin is a type which can be cured by ultraviolet rays. As shown in FIG. 12, the circuit board 60 is a multilayer glass plate having a diffuser 80 on the viewing side and a reflector 82 on the opposite side of the diffuser. The track 74 (see FIG. 11) is located on the wiring diagram surface 84. When the battery η is installed on the reflector side of the circuit board 60, a conductive epoxy resin 72 is applied between the two layers, and is electrically connected between the battery pad 70 and the wiring pattern surface 84, and one layer is not shown. The transparent UV-cured liquid epoxy resin or other sealant shown may be applied to the wiring pattern surface 84 to cover the tracks 74 and ASIC 76, while being cured to seal the tracks 74 and ASIC 76, and protect the tracks 74 & ASIC 76 from moisture. And other pollutants. The road board 60 is preferably made of two layers of glass, each layer having a thickness of about 1 cm and the track 74 is formed of a conductive ink and applied to the surface of the wiring pattern 8 4. The reflector 82 can reflect light while providing reflected light to properly image the number of the liquid crystal display 46. An integrated special integrated circuit (ASIC) 76 is fixed on the circuit board 60 and is powered by a battery 5 8 'such as a logic arrangement or a microprocessor to process electrical signals from the switch 6 2 and activate the liquid crystal display at the same time 46 produces a digital reading of the quantity dispensed in the container 16. The aSIC 76 is a control device 'and at the same time, it can be a digital integrated circuit, which serves as a control function of the internal counting', including memory, timing and the above-mentioned communication functions. If the ASIC 76 contains the above-mentioned memory and timing functions, the ASIC 76 can be set to cause the display 46 to display the additional parameter, such as the date of the latest dispensing in time and -18-this paper standard Continent + Coffee Standard (CNS ) A4 size ⑽ x 297 public hair) ----- * --- rl ----- install --- (Please read the precautions on the back & fill in this page) Printed by Consumer Cooperatives Printed A7 by Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. —______ B7_____ V. Invention Description (16), the time elapsed since the last dispensing, and the application during a predetermined period within the last 24 hours Matching times. The ASIC 76 may be further set to cause the display 46 to sequentially display the additional parameters after each dosing, or to cycle through the parameters repeatedly. Fig. 13 is a schematic plan view showing an example of a circuit device for the microelectronic pointer device 40 described above. The ASIC 76 can be provided with a program at the time of manufacture, and after each use of the installed device, the predetermined amount of the medicine remaining in the tank 16 is sensed and calculated. For example, when a full tank 6 is inserted into the inhaler assembly 10 ′, its counting device 30 is attached and fixed to the tank 16 and the upper bottom surface of the tank 16 is compressed to generate a dose from the tank 16 When the metered dose is first delivered, ASIC 76 will begin its counting process. During normal use, the tank 16 can be removed with the device 30 at any time for cleaning the inhaler assembly 10 'and then placed back in place without changing the count in progress. ASIC 76 may be set to a total count such as 200 doses during the manufacturing process. Each time the patient compresses the medicine tank 16 to obtain an inhaled medicine such as Albuter〇i®, the 'foam spring 4 2 is pressed down and pressed against the upper surface of the frame 3 2 and the frame 3 2 directions Slide inward to the bottom of the tank. Supplying sufficient pressure to overcome the impedance of the foam spring 42 will cause the switch contact piece 6 2 to lean against the switch pad 6 8. The sealing of the switch pad 62 is activated, and the microelectronic indicator device 40 is activated to subtract "one" from the existing data. After each application, the display 46 shows the amount of medicament remaining in the tank 16. This visible signal indicates the quantity of interstitial drugs stored in the tank 16 and also provides an indication when the tank 6 is near a depleted condition. Through the construction of the counting device 30 and the shape of the foam spring 4 2 to improve the -19- this paper size standard (CNS) aI ^ each (210 X 297 public love) _ ------- : -------- install -------- order --------- line (please read the precautions on the back to write this page) A7 opening force ) Provide a preset impedance to start counting, and one can ensure that, for example, when carrying a piece, it will not cause an incorrect count. The foam spring 42 can be changed in the inside and outside diameter and thickness by the selection of the handle to obtain a pressure such as 4 to 5 pounds to close the switch contact 62 (see Figure 7-8). The pseudo pressure is approximately 3 tellurium. By closely matching the pressure required to close the switch to touch ^ 62, and when delivering the medicine from the trough device 16, the error count can be minimized, and at the same time, each dose is properly reflected in the count on. Fig. 14 is a cross-sectional side elevation view (fragment view) of a trigger-activated dispenser pump 10 & mounted on a container 16a. The container 16a does not need to be transparent, so that the content of the container 16a can be determined visually. The device 30a, which is the same as the device 30 in all respects, is stuck to the trigger 17a to start the pump 10a. When the trigger is pulled by the operator's finger, a finger is placed on the top of the frame body 32a, which activates the above-mentioned ASIC 76 via the contact sheet 62. As shown previously, a foam spring 42 can be placed in the device 30a, which acts approximately within a predetermined pressure of approximately 3 to 10 pounds, which is very close to the pressure required for one dispensing, Prevent false counts during the operation of trigger 17a, while ensuring that each dose is included in the count. As a result, several of the aforementioned objectives and advantages have been achieved almost effectively. Although a single preferred example of the present invention has been published and described in detail herein, it should be understood that the present invention is by no means limited thereto, and its scope will be determined by the accompanying patent application. -20- X 2 耵 mm) -------------- install -------- order --------- line (please read the note on the back first) Please fill in this page again for details) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs