TW377274B - Novel heterocyclic and phenyl compounds and their process for preparation and use - Google Patents

Novel heterocyclic and phenyl compounds and their process for preparation and use

Info

Publication number
TW377274B
TW377274B TW084101945A TW84101945A TW377274B TW 377274 B TW377274 B TW 377274B TW 084101945 A TW084101945 A TW 084101945A TW 84101945 A TW84101945 A TW 84101945A TW 377274 B TW377274 B TW 377274B
Authority
TW
Taiwan
Prior art keywords
formula
alkyl
halogen
substituted
optionally mono
Prior art date
Application number
TW084101945A
Other languages
Chinese (zh)
Inventor
Michael Drysdale Turnbull
Harjinder Singh Bansal
Alison Mary Smith
Roger Salmon
Steven Fitzjohn
Richard Ayles Godfrey Christopher
Brian Hotson Matthew
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9404716A external-priority patent/GB9404716D0/en
Priority claimed from GB9404718A external-priority patent/GB9404718D0/en
Priority claimed from GB9404721A external-priority patent/GB9404721D0/en
Priority claimed from GB9404720A external-priority patent/GB9404720D0/en
Priority claimed from GBGB9500521.1A external-priority patent/GB9500521D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of TW377274B publication Critical patent/TW377274B/en

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  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A compound of formula (I), R-S(O)nCH2CH2CH=CF2 or a salt thereof, wherein n is 0, 1, or 2; and R is a group of formula (II) to (XXI), wherein S(O)nCH2CH2CH=CF2 group is represented by R2 or R3 in formula (II), by R2 in formula (III), by R3, R4 or R5 in formula (IV), (V), and (IX), by R2, R4 or R5 in formula (VI), (VII) and (VIII), by R3 or R5 in formula (X) and (XI), by R2 or R5 in formula (XII) and (XIII), by R5 in formula (XIV), by R1 in formula (XV), by R2 or R4 in formula (XVI), by R3 in formula (XVII), by R2 in formula (XVIII), by R4 in formula (XIX), by R3, R5 or R6 in formula (XX), and by R2 in formula (XXI); and the remaining substituents represented by R1 (when attached to a carbon atom) to R6, when present, are selected from hydrogen, nitro; halogen; cyano; -CH=NOH; C1-6 alkyl; C1-4 halo-alkyl; C1-4 alkenyl; C1-4 haloalkenyl; haloalkenyloxycarbonyl; -CONH2; mono or di-C1-2 alkylaminocarbonyl; C2-4 alkanecarbonyl; phenyl optionally mono- or di-substituted with groups independently chosen from halogen, nitro, C1-4 alkyl, C1-4 alkoxy or aminosulfonyl, -CONHSO2-C1-4 alkyl; benzyl optionally mono- or di-substituted with groups independently chosen from halogen, nitro, C1-4 alkyl or C1-4 alkoxy; phenoxy optionally mono- or di-substituted with groups independently chosen from halogen, cyano, C1-4 alkyl or C1-4 alkoxy; amino optionally mono- or di-substituted with C1-4 alkyl groups; -SH; C1-4 alkylthio; benzylthio optionally mono- or di-substituted with groups independently chosen from halogen or C1-4 haloalkyl; C1-4 alkenylthio; C2-4 haloalkenylthio; a second S(O)nCH2CH2CH=CF2 group; C1-4 alkanesulfonyl; C1-4 haloalkanesulfonyl; fluorosulfonyl; mono- or di-C1-4 alkylsulfamoyl; a 5 or 6 membered heteroaryl group optionally substituted with halogen; or any adjacent pair forms a fused 5- or 6-carbocyclic or heterocyclic ring such that the fused system is a quinoxaline, benzofuran, benzotriazine, phthalazine or imidazopyridine; R1 (when attached to a nitrogen atom) is hydrogen; C1-4 alkyl; C1-4 haloalkenyl; cyanoC1-4 alkyl; C2-4 alkoxycarbonyl; acetoxy; C1-4 alkanesulfonyl; an unsubstituted phenyl.
TW084101945A 1994-03-10 1995-03-02 Novel heterocyclic and phenyl compounds and their process for preparation and use TW377274B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9404716A GB9404716D0 (en) 1994-03-10 1994-03-10 Heterocyclic compounds
GB9404718A GB9404718D0 (en) 1994-03-10 1994-03-10 Aromatic and heterocyclic compounds
GB9404721A GB9404721D0 (en) 1994-03-10 1994-03-10 Heterocyclic compounds
GB9404720A GB9404720D0 (en) 1994-03-10 1994-03-10 Heterocyclic compounds
GBGB9500521.1A GB9500521D0 (en) 1995-01-11 1995-01-11 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
TW377274B true TW377274B (en) 1999-12-21

Family

ID=57942026

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084101945A TW377274B (en) 1994-03-10 1995-03-02 Novel heterocyclic and phenyl compounds and their process for preparation and use

Country Status (1)

Country Link
TW (1) TW377274B (en)

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