TW347388B - Oxazolidinone derivatives having adhesion receptor antagonism - Google Patents

Oxazolidinone derivatives having adhesion receptor antagonism

Info

Publication number
TW347388B
TW347388B TW084111533A TW84111533A TW347388B TW 347388 B TW347388 B TW 347388B TW 084111533 A TW084111533 A TW 084111533A TW 84111533 A TW84111533 A TW 84111533A TW 347388 B TW347388 B TW 347388B
Authority
TW
Taiwan
Prior art keywords
receptor antagonism
adhesion receptor
oxazolidinone derivatives
group
known amino
Prior art date
Application number
TW084111533A
Other languages
Chinese (zh)
Inventor
Gante Joachim
Juraszyk Horst
Raddatz Peter
Wurziger Hanns
Bernotat-Danielowski Sabine
Melzer Guido
Wiesner Matthias
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of TW347388B publication Critical patent/TW347388B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

An oxazolidinone derivative of the formula I (I) in which R1 is (group); R2 is H, A, Ac, A-SO2-, Ar-SO2- or a known amino protective group; R3 is H or A, A being a C1-C6-alkyl; D is H2N-C(=NH)- where the primary group also can provide a known amino protective group; Ac is C1-C10-alkanoyl or C7-C11-aroyl; Ar is phenyl which is unsubstituted or mono-substituted by A, or benzyl; and physiologically unobjectionable salts thereof.
TW084111533A 1994-11-02 1995-11-01 Oxazolidinone derivatives having adhesion receptor antagonism TW347388B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4439110 1994-11-02
DE19509093A DE19509093A1 (en) 1994-11-02 1995-03-16 Adhesion receptor antagonists

Publications (1)

Publication Number Publication Date
TW347388B true TW347388B (en) 1998-12-11

Family

ID=6532300

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084111533A TW347388B (en) 1994-11-02 1995-11-01 Oxazolidinone derivatives having adhesion receptor antagonism

Country Status (7)

Country Link
KR (1) KR100379996B1 (en)
AR (1) AR005224A1 (en)
CO (1) CO4520228A1 (en)
DE (2) DE19509093A1 (en)
TW (1) TW347388B (en)
UA (1) UA54367C2 (en)
ZA (1) ZA959212B (en)

Also Published As

Publication number Publication date
UA54367C2 (en) 2003-03-17
DE19509093A1 (en) 1996-05-09
KR100379996B1 (en) 2003-07-22
ZA959212B (en) 1996-07-24
DE59503324D1 (en) 1998-10-01
KR960017662A (en) 1996-06-17
CO4520228A1 (en) 1997-10-15
AR005224A1 (en) 1999-04-28

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