AR005224A1 - DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS. - Google Patents

DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS.

Info

Publication number
AR005224A1
AR005224A1 ARP950100002A ARP010000295A AR005224A1 AR 005224 A1 AR005224 A1 AR 005224A1 AR P950100002 A ARP950100002 A AR P950100002A AR P010000295 A ARP010000295 A AR P010000295A AR 005224 A1 AR005224 A1 AR 005224A1
Authority
AR
Argentina
Prior art keywords
procedure
preparation
atoms
oxazolidinone
derivatives
Prior art date
Application number
ARP950100002A
Other languages
Spanish (es)
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of AR005224A1 publication Critical patent/AR005224A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Derivados de la oxazolidinona, caracterizados por la fórmula (I) en la que R1 es de fórmula (II), R2 es H, A, Ac, A-SO2 o un grupo protector de aminoconvencional, R3 es H, A, cicloalquilo de 3 a 7 átomos de C, Ar o Ar-(CH2)k, A es alquilo de 1 a16 átomos de C, B es H, A, o H2N-C(-NH)-, D es H2N-CH2-,H2N-C(-NH) o H2N-C(-NH )-NH-CH2, en donde los grupos de amino primario también pueden estar protegidos con grupos protectores convencionales; Ac es alcanoilode 1 a 10 átomos de C o arcilo de 7a 11 átomos de C; Ar es fenilo o bencilo no sustituido o bien mono o disustituído con A, Cl, Br,I, OA, OH NO2, CN, NH2, NHAy/o NA2; m es 0, 1, 2, 3 o 4; n es 2, 3, o 4 y k es 1, 2, 3 o 4 y sus sales aceptables desde el punto de vistafisiológico. T ambién se refiere a unprocedimiento para preparar estos compuestos y el empleo de los mismos en calidad de medicamentos. Los compuestos del invento inhiben la unión defibrinógeno a su receptor correspondiente, y pueden serempleados para el tratamiento de trombosis, osteoporosis, enfermedades tumorales, apoplejías,infarto de miocaardio, esquemias, infecciones, arteriosclerosis y enfermedades osteolíticas.Derivatives of oxazolidinone, characterized by the formula (I) in which R1 is of formula (II), R2 is H, A, Ac, A-SO2 or an aminoconventional protecting group, R3 is H, A, cycloalkyl of 3 to 7 atoms of C, Ar or Ar- (CH2) k, A is alkyl of 1 to 16 atoms of C, B is H, A, or H2N-C (-NH) -, D is H2N-CH2-, H2N- C (-NH) or H2N-C (-NH) -NH-CH2, where the primary amino groups may also be protected with conventional protecting groups; Ac is alkanoilode 1 to 10 C atoms or 7 to 11 C atoms clay; Ar is phenyl or benzyl unsubstituted or mono or disubstituted with A, Cl, Br, I, OA, OH NO2, CN, NH2, NHA and / or NA2; m is 0, 1, 2, 3 or 4; n is 2, 3, or 4 and k is 1, 2, 3, or 4 and its salts are physiologically acceptable. It also refers to a procedure for preparing these compounds and their use as drugs. The compounds of the invention inhibit defibrinogen binding to their corresponding receptor, and can be used for the treatment of thrombosis, osteoporosis, tumor diseases, strokes, myocardial infarction, schematics, infections, arteriosclerosis and osteolytic diseases.

ARP950100002A 1994-11-02 1995-11-01 DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS. AR005224A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4439110 1994-11-02
DE19509093A DE19509093A1 (en) 1994-11-02 1995-03-16 Adhesion receptor antagonists

Publications (1)

Publication Number Publication Date
AR005224A1 true AR005224A1 (en) 1999-04-28

Family

ID=6532300

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100002A AR005224A1 (en) 1994-11-02 1995-11-01 DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS.

Country Status (7)

Country Link
KR (1) KR100379996B1 (en)
AR (1) AR005224A1 (en)
CO (1) CO4520228A1 (en)
DE (2) DE19509093A1 (en)
TW (1) TW347388B (en)
UA (1) UA54367C2 (en)
ZA (1) ZA959212B (en)

Also Published As

Publication number Publication date
UA54367C2 (en) 2003-03-17
DE19509093A1 (en) 1996-05-09
KR100379996B1 (en) 2003-07-22
ZA959212B (en) 1996-07-24
DE59503324D1 (en) 1998-10-01
KR960017662A (en) 1996-06-17
TW347388B (en) 1998-12-11
CO4520228A1 (en) 1997-10-15

Similar Documents

Publication Publication Date Title
PE20212302A1 (en) APOL1 INHIBITORS AND THEIR METHODS OF USE
LU90410I2 (en) Milnacipran (hydrochloride)
AR050261A2 (en) AMINO ACIDS AFFECTED BY THE ALFA-2-DELTA PROTEIN AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE TO PREPARE A MEDICINAL PRODUCT
TR200201505T2 (en) Pirazolopyrimidines as therapeutic agents
BR0010555A (en) Neuraminidase Inhibitors
ES2137998T3 (en) NEW AMINO ACID DERIVATIVES, PROCEDURE FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINED IN THESE COMPOUNDS.
CO5570667A2 (en) SUBSTITUTED SUBSTITUTE SUBSTITUTED SUBSTITUTE COMPOUNDS WITH HETEROARILO FOR THE TREATMENT OF DISEASES
GT200100137A (en) PRO-DRUGS OF 4-PHENYL-PYRIDINE DERIVATIVES.
UY27740A1 (en) NEW COMPOUNDS
RU94040390A (en) Derivatives of vinyleneazaindole, method of their synthesis, pharmaceutical composition
EA200300528A1 (en) 1-ARYL-OR 1-ALKYLSULPHONYLETHETROCYCLYLBENZAZOLES AS LIGANDS 5-HYDROXITRIPTAMINE-6
BR0014137A (en) Compound, method for inhibiting aurora 2 kinase in a warm-blooded animal, use of a compound, and pharmaceutical composition
ES2193337T3 (en) USE OF STRONTIUM SALTS FOR THE TREATMENT OF ARTROSIS.
AR029216A1 (en) NON-PEPTIDIC INHIBITING COMPOUNDS OF THE VLA-4 DEPENDENT CELL UNION IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASES; PHARMACEUTICAL COMPOSITION AND TREATMENT PROCEDURE
ECSP034744A (en) N-REPLACED N-REPLACED NMDA / NR2B ANTAGONISTS
ES2080297T3 (en) DERIVATIVES 17-G (B)-SUBSTITUTED-4-AZA-5G (A) -ANDROSTAN-3-ONA AND PROCEDURE FOR THE PREPARATION OF THESE.
UY27851A1 (en) DIFENILAZETIDINONAS REPLACED IN RING, PROCEDURE FOR PREPARATION, MEDICATIONS UNDERSTANDING THESE COMPOUNDS AND THEIR USE.
AR003121A1 (en) ADHESION RECEPTOR ANTAGONISTS, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE TO PREPARE MEDICINES AND FIGHT DISEASES
ES2038172T3 (en) PROCEDURE FOR PREPARING HETERO CYCLIC CARBOXAMIDES.
SE9901077D0 (en) Novel use
CO4840509A1 (en) 2,4 SUBSTITUTED DIAMINOPYRIMIDINES, MEDICINAL PRODUCT CONTAINING SUCH COMPOUNDS FOR THE CONTROL OR PREVENTION OF INFECTIOUS DISEASES AND PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS "
EE200000059A (en) Tetrahydro-gamma-carbolines
HUP0301551A2 (en) New use of 5ht3 and neuronal nicotinicreceptor antagonist 1-amino-alkycyclohexanes
UY26501A1 (en) SUBSTITUTED PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
AR005224A1 (en) DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS.