AR005224A1 - DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS. - Google Patents
DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS.Info
- Publication number
- AR005224A1 AR005224A1 ARP950100002A ARP010000295A AR005224A1 AR 005224 A1 AR005224 A1 AR 005224A1 AR P950100002 A ARP950100002 A AR P950100002A AR P010000295 A ARP010000295 A AR P010000295A AR 005224 A1 AR005224 A1 AR 005224A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- preparation
- atoms
- oxazolidinone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados de la oxazolidinona, caracterizados por la fórmula (I) en la que R1 es de fórmula (II), R2 es H, A, Ac, A-SO2 o un grupo protector de aminoconvencional, R3 es H, A, cicloalquilo de 3 a 7 átomos de C, Ar o Ar-(CH2)k, A es alquilo de 1 a16 átomos de C, B es H, A, o H2N-C(-NH)-, D es H2N-CH2-,H2N-C(-NH) o H2N-C(-NH )-NH-CH2, en donde los grupos de amino primario también pueden estar protegidos con grupos protectores convencionales; Ac es alcanoilode 1 a 10 átomos de C o arcilo de 7a 11 átomos de C; Ar es fenilo o bencilo no sustituido o bien mono o disustituído con A, Cl, Br,I, OA, OH NO2, CN, NH2, NHAy/o NA2; m es 0, 1, 2, 3 o 4; n es 2, 3, o 4 y k es 1, 2, 3 o 4 y sus sales aceptables desde el punto de vistafisiológico. T ambién se refiere a unprocedimiento para preparar estos compuestos y el empleo de los mismos en calidad de medicamentos. Los compuestos del invento inhiben la unión defibrinógeno a su receptor correspondiente, y pueden serempleados para el tratamiento de trombosis, osteoporosis, enfermedades tumorales, apoplejías,infarto de miocaardio, esquemias, infecciones, arteriosclerosis y enfermedades osteolíticas.Derivatives of oxazolidinone, characterized by the formula (I) in which R1 is of formula (II), R2 is H, A, Ac, A-SO2 or an aminoconventional protecting group, R3 is H, A, cycloalkyl of 3 to 7 atoms of C, Ar or Ar- (CH2) k, A is alkyl of 1 to 16 atoms of C, B is H, A, or H2N-C (-NH) -, D is H2N-CH2-, H2N- C (-NH) or H2N-C (-NH) -NH-CH2, where the primary amino groups may also be protected with conventional protecting groups; Ac is alkanoilode 1 to 10 C atoms or 7 to 11 C atoms clay; Ar is phenyl or benzyl unsubstituted or mono or disubstituted with A, Cl, Br, I, OA, OH NO2, CN, NH2, NHA and / or NA2; m is 0, 1, 2, 3 or 4; n is 2, 3, or 4 and k is 1, 2, 3, or 4 and its salts are physiologically acceptable. It also refers to a procedure for preparing these compounds and their use as drugs. The compounds of the invention inhibit defibrinogen binding to their corresponding receptor, and can be used for the treatment of thrombosis, osteoporosis, tumor diseases, strokes, myocardial infarction, schematics, infections, arteriosclerosis and osteolytic diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4439110 | 1994-11-02 | ||
DE19509093A DE19509093A1 (en) | 1994-11-02 | 1995-03-16 | Adhesion receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005224A1 true AR005224A1 (en) | 1999-04-28 |
Family
ID=6532300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP950100002A AR005224A1 (en) | 1994-11-02 | 1995-11-01 | DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS. |
Country Status (7)
Country | Link |
---|---|
KR (1) | KR100379996B1 (en) |
AR (1) | AR005224A1 (en) |
CO (1) | CO4520228A1 (en) |
DE (2) | DE19509093A1 (en) |
TW (1) | TW347388B (en) |
UA (1) | UA54367C2 (en) |
ZA (1) | ZA959212B (en) |
-
1995
- 1995-03-16 DE DE19509093A patent/DE19509093A1/en not_active Withdrawn
- 1995-10-19 DE DE59503324T patent/DE59503324D1/en not_active Expired - Lifetime
- 1995-10-31 ZA ZA959212A patent/ZA959212B/en unknown
- 1995-11-01 TW TW084111533A patent/TW347388B/en active
- 1995-11-01 UA UA95114762A patent/UA54367C2/en unknown
- 1995-11-01 AR ARP950100002A patent/AR005224A1/en unknown
- 1995-11-02 CO CO95051975A patent/CO4520228A1/en unknown
- 1995-11-02 KR KR1019950039300A patent/KR100379996B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
UA54367C2 (en) | 2003-03-17 |
DE19509093A1 (en) | 1996-05-09 |
KR100379996B1 (en) | 2003-07-22 |
ZA959212B (en) | 1996-07-24 |
DE59503324D1 (en) | 1998-10-01 |
KR960017662A (en) | 1996-06-17 |
TW347388B (en) | 1998-12-11 |
CO4520228A1 (en) | 1997-10-15 |
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AR005224A1 (en) | DERIVATIVES OF OXAZOLIDINONE, PROCEDURE FOR ITS PREPARATION AND ITS USE, AS WELL AS PHARMACEUTICAL PREPARATION THAT CONTAINS THEM AND PROCEDURE FOR OBTAINING PHARMACEUTICAL PREPARATIONS. |