^13517 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明 ( t ) 1 1 大 致 上 ，本發明係有關醫學裝置，且 較特別地 係用 於 病 1 1 患 體 内 多 種 開 口 或 切 口閉 合 之 止 血裝 置。 1 I 如 同 熟 悉 本 技 術 者 所理 解 ，現在多種外科程序實行於 /—v 請 1 1 血 管 内 或 管 腔 内 〇 例 如，在血管疾病之治療中， 諸如 動 脈 先 閲 1 I 讀 1 1 粥 狀 硬 化 ，平常之習慣像插入- -器械或導管於該動脈， 如 背_ A 1 I 一 氣 球 或 其 他 型 式 導 管於 該 動 脈 中實 行該等程 序。 此 等 之 注 意 1 程 序 通 常 之 涉 及 該 動 脈之 經 皮 穿 剌以 使導引器 之鞘 可 插 項 1 I 再 1 I 入 於 該 動 脈 中 ，然後該器械或導管之本身可透過該鞘進 填 1 入 在 動 脈 中 之 手 術 位 置。 以 此 型 式之 程序具有 一問 題 9 寫 本 頁 裝 1 僳 經 常 在 該 程 序 已 兀 成之 後 以 及 該器 械（以及任何所使 1 1 用 之 導 引 器 之 鞘 )已移開之後， 難 以在 該經皮穿 剌處 止 住 I 1 出 血 〇 1 1 冃 前 ，最為平常之治療以止住此種出血，偽由 一合 格 醫 訂 I 師 或 其 他 適 當 之 合 格 醫護 人 施 以人 為壓力於 該穿 剌 部 1 I 位 〇 此 種 人 為 壓 力 必 須施 以 足 夠 長之 時間用於 産生 止 血， 1 1 使 該 開 口 有 效 地 閉 合 以抵 擋 進 一 步出 血。於穿 剌進 入 大 1 | 腿 或 大 腿 表 面 之 動 脈 時，該壓力必須施以45分鐘或更長 線 1 以 産 生 止 血 〇 不 僅 由 高度 技 術 之 醫護 專業人員 施以 人 為 * 1 1 壓 力 浪 費 時 間 ，而且若非真正地止住出血，該 程序 •iStt 造 傳 1 I 成 流 經 血 管 之 血 液 實 質地 減 少 〇 由於 血栓像一 種可 立 即 I 1 1 發 生 於 手 術 後 期 間 中 之主 要 副 作 用，故任何諸如藉由施 1 1 加 人 為 壓 力 所 導 致 之 血流 減 少 均 非企 望的。 1 I 簡 易 之 施 用 器 (a PP 1 i c a to Γ) 裝 置，用以插入- -吸水性 1 1 栓 子 或 構 件 於 陰 道 中 ，已掲示纪 >專利文獻中。此等裝置 1 1 3 - 1 1 1 1 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 經濟部中央標準局貝工消費合作社印製 〇135J7 A7 B7五、發明説明（> ) 基本上包含：一管狀元件適於插入該陰道中；以及具備一 吸水性物質之栓子置於其中。該裝置尚包含一柱塞（ Plunger)以從該管狀元件推出栓子進入該陰道中。 該拴子亦可包今一線或澠附著其上以使該拴子可從該陰 道取回《此等裝置之實例係掲示於美國專利案號淮予 Robertson之第1191736號以及准予Washburn等人之第 1 7 9 4 2 2 1 號。 然而此等裝置只適合它們所指定之目的，並無建議使 用它們於或特別地適合於插入血管或身體其他之管腔或 管脈壁中之開口以封合該開口。 美國專利案號准予Kensey之第4744364及4852568號掲 示一種定位器械以及一閉合器或固定器用以封合组鏃中 之開口，例如：活體之血管，管腔或管脈之針孔，其傜將活 體之一部位與另一部位隔開。使用該裝置之多種方法亦 掲示於該等專利。基本上，Kensey發明之定位器械包含 一細長管狀體，具備一出口於其遠側端。該裝置之遠側 端傜透過針孔或其他開口插入。當該針孔為一動脈或其 他向管時，該管狀體之出口透過針孔插入，使該裝罝之遠 側端傜位於該血管内。一固定器配置於該細管狀體之内 且定向以使其在使用前可以精密調整或縮小形態固待於 該管狀體之内。該管狀體尚包含一射出器，以類似於柱 塞構件所設置之形式施力，大致上使該固定器被推出該 出口而進入人體之部位以與該開口接觸，例如在該血管 之内部中，然後，該固定器被展開或擴張以形成一#擴大 -4 - I — n I I n I I I I 訂 I 線 Ϊ . (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 五、發明説明（—） Γ /V 。絲 面維 表纖 接取 銜抽 織種 組一 之 在 使 抽 孔 針孔 器該針 合近該 閉接沿 或或能 器著面 定沿表 該 動 A7 B7 固 為 示 掲 被 地接 全銜 完之 能器 後合 βΒ Θ gCT 撤或 被器 體定 狀固 管該 之使 置以 裝丨 面 表 倒 内 之 織 組 該 鄰 緊 或 接 銜 地 密 緊 或 器 定 固 該 態持 形固 之以 示置 掲配 所與 利定 專固 e 面 ns表 Ke虜 依皮 患 病 沿 且 緊 拉月 被閉 If βΰ 絲 維 纖 該 孔 針 於 器 合 置 位 之絲 中維 以 各 佳 較 餓 之 ·e 合 1 結ab 所ad 及gr 以de 器10 合(b 閉質 或物 器之 定解 固降 該物 地U 可 種 血 合 封 來 用 使 被 器 合 閉 或 器 定 固 該 當 0 成 形 (請先閲讀背面之注意事項再填寫本頁) -裝. 中 管 即 示態 掲狀 luK ， 時擴 口或 切開 或展 孔其 針以 之， 構 0 Ml 種 時 開 展 其 針 該 合 封 在 及 之 置 地 解 理 可 管 6 血90 該48 過第 通之 斷 e Ϊ S 阻 η e 會 K 不予 並准 它號 ，案 利 專 於 時 流 掲 步1 進 中 號 訂 針 合 封 於 用 之 成 形 皮 經 中 織 組 在 I 種1 示 □ 切 開 隔 傜 置 裝 器 法件 方構 種持 多固 之一 似 類 體 長 細 地 體U維套 入大Μ一 用 使 示 掲 且 位 部 部 内 値 兩 之 合置 閉裝 之該 俗偽 置件 裝構 器持 合把 閉該 之 ❶ 明件 發構 y· e 合 S ί η 封 e - κ I 種及 此以 ，絲 維 纖 索 線 經濟部中央標準局員工消費合作社印製 體 合 聚 膠 ηβ 1 熔 熱1 如 諸 I 種 造 a 構P1 之2 一 以 地 佳 較 且 3 ΤΧ 成 形 質 物 之 解 降 物 生 可 之 上 之 端 側 遠 之 絲 維 纖 de於 ti造 :模 傜 01索 (P套 類之 酯示 交掲 聚所 或該 絲 維 纖 該 成構 形合 質封 物該 線與 縫線 類缝 酯該 交於 聚對 以相 地以 佳索 ί 套 較 且 ，使 的性 解撓 降可 物之 生絲 可維 傜纖 亦該 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） A7 B7 五、發明説明（4 ) 其 上或 〇棉 向泡 方縮 種壓 多一 於以 轉地 植佳 件較 件 構 合 封 該 成 形 質 物 他 子以 检性 狀水 柱吸 圓度 一 高 含具 包， 械 器 式 〇 入 寸插 尺一 之與 縮排 壓安 其傜 過置 起裝 脹器 膨合 可閉 時之 中利 體專 人ey 於ns β 放 κ 置一 當此 及 Ρ 切 與 _U 針 之 合 封 欲 .於 '置 裝 器 合 探 該 置 放 以 用 使 合 配 裝 器 合 中 其 方 之 軸 縱 之 本 狀 件管 構該 體於 狀行 管平 一 其 含以 包件 械構 器持 式固 入該 插使 該置 0 放 中係 之置 該件 之構 分持 部固 一 該 縮自 壓件 丁構 件絲 構雒 持纗 固該， 該後 時然 置 〇 配端 此倒 以遠 當之 。件 向構 定合 向封 封利 該專臓 著ey肝 UI S ， 沿 η K e ^ 苺 K J 過種W 透此織 處 組 合插 囊 膽 後械 向器騸 件式肺 構入， 伸插 延係 等 臓 心 體内 人口 1 切 任或 或孔 脈針 動之 於ΙΦ 入丨 ^ ^ ^ 當 置將 WO放 m 1* d = 望m2^ έ ΜΜ肖¥h 器¾ 中$入 體入ii Μ插該 患5 ， 病,¾後 於時然 口脈 0 出動内 之合之 端封脈 側以動 遠械該 其器在 到此其 直用使 推短 中一 件置 構位 狀此 管於 該持 從固 件可 構械 持器 固該 器 合 H,a 該 在 即 亦 端 尖 件 構 I合 推封 被Μ棉 件^泡 固 ^ 部 該Ρ,端 旦間側 一 時遠 。期置 出週裝 脹 膨 (請先聞讀背面之注意事項再填寫本頁). 裝. 訂 線· 經濟部中央標準局員工消費合作社印製 肋 後此 然。 〇 取 件抽 構被 持絲 固維 該纖 斜之 傾器 地合 效閉 有該 作而 動開 此撤 被 件 構 式 入 插 該 脈 M3 該 在 過 透 作 ，之 位步 部一 合進 封止 之停 罝而 裝面 器表 合内 閉之 該壁 S 摒 拉動 後該 向接 口銜 切位 或部 孔持 針固 之該 中到 壁直 接 銜者 入再 進。 件位 _ β 構剖 持端 固側 該遠 當之 0 件 取構 抽合 時 壁 脈 πβπ 該 件 構 合 封 該 封位 該部 縮端 壓側 可近 ’之 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 經濟部中央標準局員工消費合作社印製 A 7 B7 五、發明説明（^ ) 延伸至在該皮下組雜中之針孔或切口内至一緊接皮慮之 點。此等動作有效地從血液流經該處之通道封合該針孔， 或切口。 該專利亦包含多種其他裝置，用於閉合血管或其他開 口中之開口。PCT公告案號第W0 90/14796號掲示一種阻 塞構件與一種鎖扣構件之使用，其係定向横切該血管壁 來封合血液流經該處之切口。於美國專利准予Fowle η之 案號第5108421號中僳掲示一種栓子型式構件伴隨一種 式多種之插入栓子於一切口内之方法其他用於閉合傷口 或其他切口之裝置與技術係掲示於美國專利准予 ZiBneriaann等人之案號第4606337號以及美國專利准予 Janese之案號第5053046號中。 不管最近於此領域中之所有相關之主張，惟仍需一種 簡單且可靠之裝置以用於完成一開口之閉口，諸如在一 血管，導管或管脈中，藉由一凝膠狀物質或類似之止血物 質以及一固定器或類似組合來栓塞該開口而無需應用人 工壓力於該切口一擴大之時間週期。 發明概述 所以，本發明之概括目的像提供一種克服習用技術缺 點之總成。 本發明進一步之目的傺提供一種閉合器總成以有效地 用於封合血管，導管或管脈中之針孔或其他開口而無需應 用人工壓力於該處且不會造成通過該血管中血流大量減低。 本發明再進一步之目的偽提共一種插入式器械_，構造 -7 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） — .— — II 1.*.11 裝— — II 訂 II 線 (請先閲讀背面之注意事項再填寫本頁) ^3〇J7 A7 B7 五、發明説明（办） 針 固U _ 一合罾 置 ί 黏 效2織 以Τ中4 Μ 脈時 管®I㈣ 搂 或以Η 纖 管用乡 導’一 ，内如 管其諸 血於或 於器狀 入合膠 插閉凝 地他 一 實其射 確或注 可件， 且構 。串^然 焉 丢 ， 簡定孔 後 合 封成 地總 單器 簡合 且閉 ell 地種 濟一 經供 以提 中像 口的 切目 該一 於再 質之 物明 血發 止本 之 □ 切 該 偽 其 性動 收移 吸被 可地 之暫 美短 完可 具後 中之 體成 患總 病器 在合 内閉 期該 週入 間插 時於 之患 短病 對許 相允 用 成 總 體 整 ell 種1 供 提 由 藉 偽 的 巨 他 其管 與血 等之 該體 之活 明一 發合 本封 以 成 達 以 P 開 中 之 壁 脈 管 或 管 導 接 於 用 體 狀 管1 有 具 狀 管 該 從 置 設 像 成 總 器 械合 器诩 式該 入。 插内 一 其 含於 包成 成總 總‘器 器合 入閉 插該 該受 成 形 所 件 奪 榍 狀 管 長 細 之 分 上部 致位 大定 。側 出遠 推一 體及 含 端 末管 1 血 具於 分引 部導 管 導 (請先閲讀背面之注意事項再填寫本頁) -裝· 分位 部定 位側 定遠 側該 近丨 1 備 具 1 由 俗 體 狀 管 該 體 中他 其其 於或 口脈 開管 被 口 開 該 過 透 為 置 設 且 内 腔 訂 地 疑 <^ ^ # 較，構 件絲 含質 包物 上之 致置 大裝 成合 總封 器一 合成 閉形 之似 明類 發或 本狀 ，膠 含 包 件 構 器 定 固 該 部 接 銜 織 組 構維向 器纖方 定一單 固及以 一 以且 : ，位 經濟部中央標準局貝工消費合作社印製 過 通 止 阻 則 中 向 方 反 相 在 但旨 , 諸 形一 構含 來包 口置 開裝 該合 過封 穿該 如 質 物 狀 膠 凝 之 劑 箸 黏 織 〇 含 處其 該， 當纖 I,該 質 物， 之 素 維 纖 或 件 構 絲 維 纖 該 te接 la銜 ry可 ac時 no化 ya固 (C或 酯燥 酸乾 烯質 丙物 基狀 氣膠 1 凝 有該 該 與 件 構 器 定 固 該 於 接 地連 佳時 較壁 牛脈 件管 構 長 了 1 , 偽管 件血 構該 絲跨 維横 以 伸 延 在 夠 足 備 具 種 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 五、發明説明（ r A7 B7 來 質 成 以 成 總 器 入 插 或 體 載 該 縱 操 物1 合含 縫包 之法 度方 長用 之使 間之 置明 裝發 合本 封 該總 於器管 件入血 奪 § J 構插人 器該病 定 〇入 固端進 該放而 位開鞘 定或之 地端器 始由引 初自導 以之一 件體過 構載經 器該引 定於導 固接被 該鄰端 及而放 内開 體之 載成 或 管 導 放 口開 開之 之成 中總 脲器 管入 捅 該 從 件 器 定 固 之 成 成 總 器 入 插 該 作 操 總’ 器後 合然 S. 〇 該出 ， ,一二一 推 後 然 件 構接 器銜 定相 固織 該組 引之 端之 牽 部 接 銜 織 組 P 人 病 接 鄰 上 致 大 與 部 接 銜 雜 组 之 件 構 器 定 固 該 使 初 少 至 (請先閲讀背面之注意事項再填寫本頁) •裝· 管 血 之 處 該 流 液 從 地 寺 暫地 fcb 或桂 地較 始 合 開凝 該射 合注 封於 脈用 管種 或一 管含 導包 丨亦 成 總 器 入 插 之 明 發 本 該 著 沿 且 内□ 切 之 脈 管 或 管 導 管 血 該 接 鄰 於 質 物 狀 0 近或 靠個 於一 射含 注包 之可 質位 物部 狀此 膠之 凝成 之總 劑器 著入 黏插 素 。 維中 纖口 如切 諸之 使器 絲定 維固 纖該 分 部 之 成 總 器 射 注管 式血 離該 分著 或沿 體件 整構 一 絲 為維 件纖 構與 塞器 柱定 個固 多旦 時 置 放 脈 管 或 管 導 凝 該點 用優 使之 〇 劑 内著 口黏 切織 於組 射收 注吸 質物 物生 狀可 膠 一 凝如 該能 許功 允有 可具 質 物 狀 膠 該 接 銜 其 件 構 絲 維 纖 與 器 定 固 該 持 保 地 固 訂 線 經濟部中央標準局員工消費合作社印製 射 注 被 質 物 狀 膠 凝 該 在 且 緊,| 以内 件置 構位 絲之 維中 纖口 管 血 該 著 沿 件 奪 榑 器 定 固 該 持 保中 地明 暫發 短本 後於 該 該 孔 針 或 C或 脈孔 管針 或該 管供 導提 ，要 首 係 件 構 器 定 固 該 信 確 可 件 即構 亦器 合定 t 固 封.bsC Μ該 之 ， 性此 時因 暫。 種止 一 為 之化 口固 切或 置 設 質 物 狀 膠 凝 該 到 直 週 短 當 相 在 — 1 種 1 以 可 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 五、發明説明（分） A7 B7 多 示 掲 於 小 或 於 等 地 佳 較 且 間 時 解 溶 之 件 構 器 定 固 之 收 成吸 形再 質可 物之 之中 解利 溶專 内ey 間ns 時Ke SSI 種 適 外作 此場 膠 凝 該 變 當 之 質如 物例 狀.： 可 成. 合 現 令 側 床 在 求 需 患 病 各 外 該 於 患 病 該 依 可 成 合 之 狀 膠 凝 該 較所 或往 速以 。 快較濟 較實經 為確為 整的較 諝示且 而掲單 量所簡 劑處為 血此較 凝於造 抗明製 之發之 受本置 接¾裝 所Μ合 &同Μ Sr— <111 ， 種 之化多 法固之 方速出 科慢提 優 之解 隨理 伴於 多易 計較 及現 的呈 目而 他圖 其附 之合 述明結 簡發與 式本述 圖 詳 列 下 照 參 由 藉 將 點 中 (請先閲讀背面之注意事項再填寫本頁) .裝· 圖 視 正 面 側 一 傜 固建 之明 構發 建：本 明依 發種 本一 依之□ 導開 於之 用中 出其 示合 ’封 以 中 體 活 於 件 構 圖器 定 器 引 導 與 成 總 器 入 二 m 插 之 •， 圖圖 面出 切示 横， 分 部 之 置 裝 合 封 之圖 構 圖 視 正 面 侧1 僳 導 於 入 • lm 插 分 部 1 之 體 狀 管 該 中 其 圖 面 切 横 分中 部鞘 之之 鞘器 之引 中 鞘 之 圖器 引 導 於 入 插 成 總 器 入 捅 出 示 訂 圖 面 切 横 分 部 之 中 管 圖血 視患 正病 面於 側放 之置 大且 效，側 一 ί 一 係 偽 經濟部中央標準局員工消費合作社印製 面 切 横 分 画部 之 忡 管 血 人 病 入 進 件 構 器 定 固 引 導 出 示 圖 視 圖 圖 視 側 器 定 固.之口 圖出 側 遠 成 總 器 入 插 於 觸 接圖 入面 進切 引横 牽分 被部 出之 示件 ’構 固 圖中 視其 側^ 0 二 6 切 圖横 分 部 之 出 撤 之 成 總 器 入 插 中 孔 針 在 出 示 觸 接 件 構 器 定 壁 管 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明 ( 9 ) 1 1 圖 7係 一 1 軸 画 示出插入於部分撤 出 之 插 入 器 總 成中 1 1 之 注 射器 總 成 以 及 附於纖維絲構件與 病 人 皮 虜 間 之 注射 1 I 器 構 件之 部 分 横 切 面圖； 請 1 1 圖 8係- -側視圖， 示出注射凝膠狀物 質 於 針 孔 中 之 部分 先 閲 1 I 讀 1 横 切 面； 背- 1 1 之 1 圔 9係- -側視圖， 示出本發明之較佳 實 施 例 之 較 佳 定位 注 意 I 之 部 分横 切 面 事 項 1 I 再 1 I 圖 10傜 一 側 視 圖 ，示出卞發明另一 實 施 例 之 部 分 横切 填 1 面 圖 9 / 寫 本 頁 裝 1 圖 11傜 一 側 視 圖 ，示出在圖10中所示之本發明實施例 1 1 之 注 射器 總 成 之 部 分横切面圖； 1 I 圖 12係 一 側 視 圖 ，不出在圖10中所不之實施例之插入 1 1 訂 1 器 總 成之 柱 塞 構 件 於延伸位置之部分 横 切 面 圖 9 圖 1 3傜 本 發 明 類 似於圖10至12中所 示 實 施 例 之 另 一實 1 I 施 例 之側 視 画 ，其中凝膠狀物質透過- -出口注射， 該 出口 1 1 開 口 於靠 近 管 狀 物 構件之遠側端； 1 I 圖 1 4偽 一 侧 視 圖 ，示出在圖13中所示之本發明實施例 線 1 之 注 射器 總 成 之 部 分横切面圖； - 1 1 圖 15俗 一 側 視 圖 ，不出在圖13中所不之實施例之插入 - 1 I 器 總 成中 之 凝 膠 狀 物質於管狀體自切 P 取 出 前 之 部 分横 1 1 切 面 圖； 1 1 圖 1 6僳 一 側 視 圖 ，示出本發明另一實施例之注射器總 1 I 成 之 部分 横 切 面 圖 9 1 1 圖 1 7偽 一 側 視 圖 ，示出在画16中所示之g :施例之 •注 .射 1 1 器 總 成沿 m 維 絲 構 件位於針孔中之部 分 横 切 面 圖 9 1 I -1 1 - 1 1 1 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明 ( ) 1 圖 18係 一 側 視 圖，示 出在 η 1 6中 所示之 實 施 例 之 注 射 1 1 器 總 成 ，其 ΐ凝膠狀物 質注 射 於切 口中之 部 分 横 切 面 圖； I I 圖 1 9僳 一 倒 視 圖，示 出類 似 於圖 1 6中所 示 之 實 施 例 之 /^-Ν 請 1 1 注 射 器 m 成 另 一 實施 例 之部分横t 刀面圖； 先 閱 I | 1 圖 20僳 正 面 透視 圖 ，示 出 在圖 1 9中所 示 之 實 施 例 之 背- 面 1 I 夾 構 件 9 1 I 圖 2 1係 一 側 視 圖，示出在 圖 1 9中 所示之 實 施 例 之 凝 膠 事 項 1 I 再 1 I 狀 物 質 ，夾構件以及固定器 構 件於 病人身 體 之 切 Ρ 中 之 填 1 部 分 横 切 面 圖 〇 寫 本 頁 裝 1 本 發 明 較 佳 形 式 詳述 1 I 現 詳 加 參 照 該 等圖 式 中之諸圖， 其中相 同 之 字 等 述 及 1 1 相 同 之 零 件 ，大致上， 圖 1所 示 之20 處，係- -種裝置用於完 I 1 成 活 體 之 血 管 ，導管或管脈 中 切口 ,孔口或其他開口之閉 訂 I 合 〇 當 該 裝 置 2 0 配合 血 管内之程序使用時， 諸 如 血 管 放 1 | 射 線 攝 影 之 顯 影 劑注 射 ，血 管 内汽 球成形 術 以 及 其 他 形 1 1 式 之 粥 樣 硬 化 動 脈之 管 道再生術， 瓣膜切 除 術 等 ，均具有 1 | 待 殊 之 實 用 〇 然 而，應理解 該 裝置 可用於 止 血 性 地 封 合 線 病 人 體 内 之 其 他 型式 之 血管， 導管 ,管脈或體腔内諸如在 - 1 1 各 種 腹 腔 鏡 檢 査 ，關節鏡檢 査 或其 他程序 中 之 針 孔 或 其 - 1 I 開 口 〇 所 以. ,可了解的像本 發 明於 本文中 所 含 之 說 明 傺 I 1 有 相 對 於 諸 如 動 脈經 皮 穿刖之封合，本發 明 之 裝 置 2 0 尚 1 1 具 有 多 種 應 用 或 使用 〇 如本文中用 ί使用之名詞" 凝 膠 狀" 1 I 意 指 含 一 種 具 有 諸如 稍 黏物質，懸 膠液或 糊 狀 物 等 之 寬 1 1 範 圍 黏 度 之 物 質 〇 1 1 -1 2_ 1 1 1 1 本紙張尺度適用中國國家標準（CNS ) A4規格（21 OX297公釐） 7 A7 B7 經濟部中央標準局貝工消費合作社印製 五、發明説明 ( t ( ) 1 1 於 描 述 該 整 體 裝 置 2 1 3之 前，概要說明一種典型，習知之血 1 1 管 内 之 外 科 程 序 ，例如 ，一種使用經皮切開或穿剌之導管 1 I 器 械 ，將對該裝置20獲得最佳之理解。於此一程序中，一 ✓—*. 請 1 1 種 諸 如 血 管 放 射 線 攝 影 之針（未圖示）之插管經皮地透過 先 閲 1 I 讀 1 皮 Μ 插 入 諸 如 大 腿 動 脈 24等之動脈中用於該器械期望插 背 δτ 1 I 入 之 位 置 ，該插管針保持定位以及一種迷氣導線（mini- 1 1 g u i d lewire),之可撓曲末端（未圖示）接著穿過該插管進 事 項 1 I 再 1 I 入 該 動 脈 中 所 期 望 之 深 度（亦即，沿該處之縱軸之位置）， 填 1 一 旦 該 迷 氣 導 引 線 定 位 ，移開該插管針而留下該導引線 寫 本 頁 1 於 該 處 ，然後， 一 種 習 知 導引器之鞘2 6以及一動脈擴張器 1 1 (未圖示） 透 過 針 孔 28 越 過該導引線而進入動脈24,然後， 1 | 移 開 該 導 引 線 與 擴 張 器 而留下該鞘26於該處，接箸，導管 1 1 (未圖示）或 其 他 血 管 内 器械透過該導引器之鞘2 6插入且 訂 1 穿 入 動 脈 至 所 期 望 之 血 管内位置，例如，粥樣硬化動脈之 | 阻 塞 位 置 〇 一 旦 該 血 管 内之程序完成時，該導管或器械 1 1 即 移 走 〇 然 後 ，可移走該鞘26而外科醫師或其他熟習之 1 | 專 業 者 以 先 ·> j,. 刖 所 要 求 之 施加人為壓力於該經皮穿剌針孔 線 1 直 到 止 血 生 效 〇 在 許 多 病患中，此需至少30分鐘之人為 1 1 壓 力 〇 - 1 I 大 致 上 ,本發明之裝置20可達成在動脈中，其他身體導 1 1 管 或 舌 脈 中 之 經 皮 或 其 他形式之針孔，切口或開口之止 1 1 血 性 閉 合 而 無 需 施 加 人 為壓力於該處。所以，一旦導管 1 I 或 其 他 血 管 内 器 械 被 移 走，但較佳地，該鞘26仍留於該處 1 1 本 發 明 之 裝 置 2 0 即 可 透 過該鞘26插入於動脈24中且作業 1 I 為 推 出 閉 合 器 或 固 定 器 構件30(稍後說明）進入動脈中， 1 I -1 3 - I 1 1 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 五、發明説明（—） 大 ο 3 件 構 器 定 固該 該接 至 更 以 8 2 孔 針 後 A7 B7 且 壁流 管血 血之 接口 鄰切 引該 牽經 後合 向封 排地 安時 被暫 上能 致少 鄰 然 性 血 止 或 / 與 狀 膠 凝 til 種1 該 而 孔 針 該 入 構 器 定 固 該 g ，切 後J 然？ 射：針 注走該 被移經 質被合 物著封 接以 成處 總該 器在 入留 插質 與物 鞘狀 之膠 器凝 引與 導件^ 13517 A7 B7 Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of Invention (t) 1 1 Generally speaking, the present invention is related to medical devices and is more particularly used for various openings or incisions in patients with disease 1 1 Closed hemostatic device. 1 I As understood by those skilled in the art, a variety of surgical procedures are now implemented in / -v please 1 1 in the blood vessel or lumen. For example, in the treatment of vascular diseases, such as arterial first reading 1 I reading 1 1 atherosclerosis It is common practice to insert instruments or catheters into the artery, such as a balloon or other type of catheter in the artery to perform these procedures. These notes 1 The procedure usually involves percutaneous penetration of the artery so that the introducer's sheath can be inserted 1 I and then 1 I into the artery, and then the instrument or catheter itself can be filled through the sheath 1 into the surgical site in the artery. There is a problem with this type of procedure. 9 Write this page. 1 It is often difficult after the procedure has been completed and after the device (and any sheath of the introducer used in 1 1) has been removed. Stop the I 1 bleeding at the puncture site. The most common treatment before the puncture is to stop the bleeding. It is assumed that a qualified medical practitioner or other appropriate qualified medical person applies artificial pressure to the puncture site. 1 I position. Such artificial pressure must be applied long enough to produce hemostasis. 1 1 effectively close the opening to prevent further bleeding. When puncturing into the arteries of the thigh 1 | leg or thigh surface, the pressure must be applied for 45 minutes or longer 1 to produce hemostasis. Not only is artificially applied by highly skilled medical professionals * 1 1 pressure wastes time, but if not To really stop the bleeding, the procedure • iStt creates 1 I. The blood flow through the blood vessels is substantially reduced. Since the thrombus is like a major side effect that can occur immediately after surgery 1 1 1, any such as by applying 1 1 The reduction in blood flow caused by artificial stress is not expected. 1 I simple applicator (a PP 1 i c a to Γ) device for inserting--water-absorbent 1 1 plug or structure in the vagina, has been shown in the patent document. These devices 1 1 3-1 1 1 1 The paper size is applicable to the Chinese National Standard (CNS) A4 (210X297 mm). Printed by the Beigong Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 135J7 A7 B7 V. Description of the invention (> ) Basically contains: a tubular element suitable for insertion into the vagina; and a emboli with a water-absorbing substance placed in it. The device also contains a plunger to push the embolus from the tubular element into the vagina. The tether can also be wrapped or attached to the thread so that the tether can be retrieved from the vagina. Examples of such devices are shown in U.S. Patent No. 1191736 by Huai Yu Robertson and granted to Washburn et al. No. 1 7 9 4 2 2 1. However, these devices are only suitable for their designated purposes, and it is not recommended to use them for or to be particularly suitable for insertion into an opening in a blood vessel or other lumen or vessel wall of the body to seal the opening. U.S. Patent No. 4744364 and No. 4852568 granted to Kensey show a positioning device and a closure or fixator for closing the opening in the group, such as: the blood vessel of the living body, the pinhole of the lumen or the vessel vein, which will be One part of the living body is separated from the other part. Various methods of using the device are also shown in these patents. Basically, the positioning device invented by Kensey consists of an elongated tubular body with an outlet at its distal end. The distal end of the device is inserted through a pinhole or other opening. When the pinhole is an artery or other directional tube, the outlet of the tubular body is inserted through the pinhole, so that the distal end of the dressing is located in the blood vessel. A holder is arranged in the thin tubular body and oriented so that it can be finely adjusted or reduced in shape before being used to be fixed in the tubular body. The tubular body also contains an ejector that exerts force in a form similar to that provided by the plunger member, generally causing the holder to be pushed out of the outlet and into the part of the human body to contact the opening, for example in the interior of the blood vessel ， Then the fixture is expanded or expanded to form a # Expansion-4-I — n II n IIII Order I line Ϊ. (Please read the precautions on the back before filling this page) This paper size is applicable to Chinese national standards ( CNS) A4 specification (210X297 mm) V. Description of the invention (—) Γ / V. The silk surface dimension fiber is connected with the drawing fabric group. The pinhole of the drawing hole is closed to the closed edge or the surface of the device is fixed. The A7 B7 is fixed to show that it is connected to the ground. After the energy device is completed, the βB Θ gCT is removed or fixed by the body. The solid tube should be installed to the woven group inside the surface. The adjacent or closely connected ground is tight or the device is fixed in this state. It ’s a good idea to set up the device and the Liding specialist to fix the e-surface and the Keruyi skin along the edge of the skin and tighten the month. If βΰ silk fiber is used, the hole needle is in the wire of the device. More hungry · e in one knot ab, ad and gr in de device 10 in (b closed substance or fixed demolition of the object to the object U can be blood sealed to use the closed or fixed device 0 Forming (please read the precautions on the back before filling in this page)-Install. The middle tube shows the shape of luK, when it is flared or cut or the hole is opened, the needle should be opened when the 0 Ml type is constructed. Sealed and placed to cleave can manage 6 blood 90 the 48 through the first break e Ϊ S resistance η e will K will not allow and allow the other number, the case is dedicated to the time flow step 1 into the medium stitching and sealing the used forming leather warp in the weaving group in I type 1 shows □ cut the partition of the device This kind of multi-solid-like body is long and thin, and the U dimension is inserted into the large M-use. The common pseudo-assembly device that holds and closes the two parts in the position part is closed and closed. ❶ Design of the open article y · e in S ί η seal e-κ I and so on, silk fiber fiber cord Central Economic Bureau of the Ministry of Economic Affairs Employee Consumer Cooperative Printed body polyglue η β 1 fusion heat 1 as I Build a structure P1 of 2-a fine fiber and a 3 TEX shaped material solution can be generated on the end of the end of the far side of the silk fiber is made in ti: Moo 01 cable (P sets of esters show cross The polysilicon or the silk fiber, the conformal composite seal, the thread and the suture-like seam ester should be intersected in the polypair to compare with each other, so that the properties are deflexed, and the raw silk is reduced. Kewei Fiber also conforms to the Chinese National Standard (CNS) Α4 specification for this paper standard (210Χ297mm) A7 B7 V. Description of the invention (4) The above or ○ cotton shrinks to the bubble side and presses more than one to seal the shaped substance with the better planting of the transferred piece and the piece. The roundness is high, including the bag, the mechanical type, the input inch, the first one, and the shrinkage pressure. It is set up. The expansion device can be expanded and closed when the expansion device is closed. The special person ey puts it in ns β. This and the combination of the P cut and the _U needle. In the 'installer, explore the placement to make the body with the axis of the side of the adapter fit the pipe structure of the body is flat It consists of holding the package mechanically fixed into the plug so that the component holding part of the component placed in the center is fixed and the shrinkage self-pressing component is made of a wire structure and the component is fixed. However, it is far from the end of the match. The piece-oriented configuration and the direction-sealed seal facilitate the specialization of ey liver UI S, along with η K e ^ berry KJ, through W, through this weaving place, the combined insertion of the gallbladder, the posterior mechanical insertion of the bladder, and the extension of the implant. It ’s the same as the population in the heart. 1 cut off or pinhole pulse to the ΦΦ into the ^^ ^ ^ when placed WO put m 1 * d = 望 m2 ^ έ ΜΜ 肖 ¥ h ¾ middle $ 入 体 入 ii Μ Insert the disease 5 and get sick, and then seal the vein side at the end of the mouth 0 out of time to move the vein side to move the mechanical device. At this point, it is used straightly so that the push is short. Since the holding firmware can construct a mechanical holder to fix the device H, the current tip member structure I and the push-sealed quilted cotton piece ^ bubble solid ^ the part of the P, the end of the side is a moment away. Expect weekly expansion and expansion (please read the precautions on the back before filling in this page). Installation. Threading · Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs. 〇The fetching structure is held by the wire holding the fiber oblique inclinator. The operation is closed and the operation is started. The quilting structure is inserted into the pulse M3. After stopping, the face S is closed and the wall S is closed. After pulling, the facing interface will be cut into position or the hole will hold the pin to the wall directly and then enter. Position _ β configuration cut the end of the fixed side of the remote should be 0 when the structure is pulled out of the wall pulse π βπ the structure of the seal seal the position of the contraction end is close to the side of the paper's standard is applicable to the Chinese national standard ( CNS) Α4 specification (210X297 mm) A 7 B7 printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of the invention (^) Extends into the pinholes or incisions in the subcutaneous complex to a skin point. These actions effectively seal the pinhole, or incision, from the channel through which blood flows. The patent also contains various other devices for closing openings in blood vessels or other openings. PCT Announcement No. W0 90/14796 shows the use of a blocking member and a locking member that are oriented transversely to the vessel wall to seal the incision through which blood flows. U.S. Patent Grant Fowle η Case No. 5108421 shows a plug-type member with a variety of methods for inserting a plug into all mouths. Other devices and techniques for closing wounds or other incisions are shown in the US patent Case No. 4606337 granted to ZiBneriaann et al. And No. 5053046 granted to Janese by the US Patent. Regardless of all recent claims in this field, there is still a need for a simple and reliable device for closing an opening, such as in a blood vessel, catheter, or vessel, by a gel-like substance or the like Hemostatic substance and a holder or similar combination to embolize the opening without applying artificial pressure to the incision for an extended period of time. SUMMARY OF THE INVENTION Therefore, the general purpose of the present invention is to provide an assembly that overcomes the disadvantages of conventional technology. A further object of the present invention is to provide a closure device for effectively sealing blood vessels, pinholes or other openings in catheters or vessels without applying artificial pressure there and without causing blood flow through the blood vessels Significantly reduced. A further object of the present invention is to provide a total of a plug-in device _, structure -7-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) — .— — II 1. *. 11 Pack — — II Order II line (please read the precautions on the back before filling in this page) ^ 3〇J7 A7 B7 Fifth, the description of the invention (office) Needle solid U _ 一 合 罾 置 ί Sticky effect 2 woven with Τ 中 4 Μ pulse time tube ®I㈣Hug or use Η fibrous tube to use the town guide, one is as if the blood is in the device or the device is inserted into the glue, and it can be shot or injected, and the structure is correct. The string ^ Ran Yan lost, after the hole is fixed and sealed into a total single unit is simple and closed to the seed, once the image is provided to the eye of the eye, it should be the one that stops the original blood from regenerating the thing. Pseudo-sexual mobilization and aspiration can be used in the United States for a short period of time. After the short period of time, the body's total disease can be used in the closed period of the week. For the purpose of providing a living body of the body, which is borrowed by a fake giant other tube and blood, to seal the wall vessel or tube opened with P. It is connected to the body tube 1 with a shaped tube. It should be inserted from the installation device into the main instrument. Insert it, which is included in the assembly of the final assembly of the assembly, and close the insert. The upper and lower parts of the shape of the tube that are shaped by the shape-retaining component are positioned in a large position. Side-to-side push-out integration and end-to-end tube 1 blood guide in the guide tube of the splitter (please read the precautions on the back before filling out this page) Vulcan body-shaped tube in the body, other or in the opening of the veins, the mouth is opened, the permeation is set and the inner cavity is ordered. ≪ ^ ^ # Compared, the large package on the material containing the silk Synthesizing the total sealer into a closed shape resembling a plain hair or a true shape, the plastic-containing package structure fixes the connection of the organization and the fabric, and the fiber is fixed to a single solid and one and: and the Ministry of Economy The printing of the pass-through stop printed by the Beigong Consumer Cooperative of the Central Bureau of Standards is reversed by the central government. All forms and configurations include the opening and closing of the sealant and the agent-like gelatinous sticky cloth. Including, when the fiber I, the substance, the element fiber or the structure fiber element, the te is connected to the la and the element can be converted into a solid (C or ester dry acid dry vinyl propyl-based aerogel 1 Condensed with the device and fixed to the ground connection When the tube structure is longer than that of the wall cattle veins, the structure of the pseudo tube is transversal to extend enough to prepare a variety of paper. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm). V. Description of the invention (R A7 B7 is to be inserted into the main assembly or loaded with the longitudinal manipulator 1 and the length and width of the seam package is used to make the cover of the seal and the seal should be inserted into the blood vessel § J. Insert the human device. The disease is fixed. The solid end is inserted into the place and the sheath is placed or the end device is started by the lead. It is guided by a piece of body through the structure. The lead is fixed to the lead. Adjacent to the end of the open body or the opening of the tube guide opening, the main urea tube is inserted into the device, and the fixed device is inserted into the operating device. S. 〇The time comes, one-to-one push-in-place connector is fixed and weaves the lead of the end of the group. The structure should be fixed so that it is the first time (please read the precautions on the back before filling (This page) • The place where the blood flows from the temple is temporarily fcb or Guidi. The injection is sealed in the pulse tube or a tube with a guide bag. The clear hair should be along the inwardly cut blood vessel or catheter. The blood should be adjacent to the material. Insert the intercalator. If the dimensional fiber port is cut, the organ wire will be fixed and the solid component of the segment will be injected into the tube. The blood will be separated or reorganized along the body to fix the dimensional fiber structure and the plug column. Place the vessel or tube to guide the coagulation at this point. Use an excellent agent to stick and cut and woven into the group to inject the injectable substance. The coagulation of the substance is gelled. If it can be used, the substance can be glued. Connected to its components, wire and fiber are fixed with the device. The secured land is fixed and fixed. The Ministry of Economic Affairs Central Standards Bureau employee consumer cooperative prints the injection. The injection is gelled and should be tight. | The medium fiber mouth tube blood should be fixed along with the edge grabber. The holding Zhongdi Ming will temporarily issue a short copy to the hole needle or C or pulse hole tube needle or the tube for guidance and extraction. Dingguo believes that the letter can be built and the device is fixed tguofeng.bsC Μ should be, this time is temporary. The only way is to cut the solid mouth or set the material to be gelled to the short period of the straight circle-1 kind 1 to the paper size applicable to the Chinese National Standard (CNS) Α4 specification (210X297 mm) V. Invention Explanation (points) A7 B7 mostly shows that it is small or better than other places, and it is better to be dissolving in the middle of the harvesting and refining material. The field should be gelled in the field. The proper quality should be like the physical condition .: It can be formed. If the side bed is in need of the disease, it should be gelled according to the condition. To. Faster, more economical, more practical, more accurate and more accurate, and the amount of the simple agent is blood, which is more condensed to the hair of the anti-Ming system. — ≪ 111, the solution of the multi-methods and the method of formulating and improving the speed and speeding up the solution is accompanied by multiple easy calculations and present presentations. Please refer to the reference for details (please read the precautions on the back and then fill out this page). Install and build the construction of Ming Ming on the front side of the view: according to the design of the original □ The guide is used to show the seal, the middle body is used in the composition, the guide of the stator, and the totalizer is inserted into the two meters. The figure shows the cross section, and the placement of the seal is divided. The front view of the drawing is viewed from the front side. 1 Suddenly lead into the lm. The body-shaped tube inserted into the subdivision 1 in which the drawing of the sheath is guided across the central sheath of the sheath. Present the tube drawing, cut across the horizontal section, and see the diseased side on the side It ’s a big and effective one. It ’s a printed part of the Department of Pseudo-Ministry of Economy, Central Bureau of Standards, Employee Consumer Cooperative, printed cut-and-segmented, divided into the drawing department. Ding Gu. The output side of the mouth diagram is inserted into the contact surface of the contact diagram. The cutting edge is drawn out of the indicator. The side view of the fixed figure is ^ 0 two 6. Withdraw the final assembly into the hole pin and show the contact piece and the fixed wall tube. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) A7 B7 Printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economy. Description of the invention (9) 1 1 Figure 7 is a 1-axis drawing showing the syringe assembly inserted into the partially withdrawn inserter assembly 1 and the injection 1 I device attached between the fiber wire member and the patient's skin Partial cross-sectional view of the component; please 1 1 Figure 8 is a side view showing the part where the gel-like substance is injected into the pinhole Read 1 cross section; back-1 1 of 1 圔 9 series--side view, showing the better positioning of the preferred embodiment of the present invention. Note the partial cross section of I 1 I then 1 I Figure 10 Wong side view , Showing a partial cross-section of another embodiment of the Bian invention. Fig. 9 / Writing a page load 1 Fig. 11 A side view showing the syringe assembly of the embodiment 1 1 of the invention shown in Fig. 10 1 I FIG. 12 is a side view showing the insertion of the plunger member in the extended position of the embodiment 1 shown in FIG. 10. FIG. 9 FIG. 1 3. The present invention is similar to another embodiment of the embodiment shown in FIGS. 10 to 12. The side view of the embodiment 1 I, in which the gel-like substance is injected through the-outlet, the outlet 1 1 is opened near the tubular member Distal end; 1 I FIG. 1 4 a pseudo side view showing the embodiment of the invention shown in FIG. 13 Line 1 is a cross-sectional view of a part of the syringe assembly;-1 1 Figure 15 is a side view showing the insertion of the embodiment shown in Figure 13-1 I The gel-like substance in the device assembly is in the tubular body The self-cut P is a partial cross-sectional view before taking out 1 1; FIG. 1 1 FIG. 16 is a side view showing a partial cross-sectional view of a total portion of the syringe 1 I of another embodiment of the present invention. FIG. 9 1 1 FIG. Side view, showing g shown in drawing 16: Example of Example • Note. Shot 1 1 Transmitter assembly along the cross section of the part where the m-dimensional wire member is located in the pinhole Figure 9 1 I -1 1-1 1 1 This paper scale applies the Chinese National Standard (CNS) A4 specification (210X297 mm) A7 B7 Printed by the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention () 1 Figure 18 is a side view, shown in η 1 6 The injection device assembly of the illustrated embodiment, the cross-sectional view of the portion where the gel-like substance is injected into the incision; II Figure 19 An inverted view showing Similar to the embodiment shown in FIG. 16 / ^-Ν Please 1 1 syringe m into another part of the transverse t blade view; read first I | 1 FIG. 20 front perspective view, shown in the figure 1 Back-face 1 of the embodiment shown in 9 1 I clip member 9 1 I FIG. 2 1 is a side view showing the gel matter of the embodiment shown in FIG. 1 1 I then 1 I-like substance , The filling of the clip member and the fixator member in the cut of the patient's body 1 part of the cross-sectional view 〇 write this page 1 detailed description of the preferred form of the present invention 1 I now refer to the drawings in these drawings in detail, where The same words refer to the same parts of 1 1. Generally, the 20 places shown in FIG. 1 are used to complete I 1 incisions, orifices or other openings in living vessels, catheters or vessels When the device 20 is used in conjunction with intravascular procedures, such as Vascular radiography 1 | Imaging agent injection for radiography, intravascular balloon angioplasty and other types 1 1 atherosclerotic artery regenerating, valvectomy, etc., all have 1 | Understand that the device can be used to hemostatically seal other types of blood vessels, catheters, vessels or body cavities in patients with sutures such as pinholes in various laparoscopy, arthroscopy or other procedures or- 1 I opening 〇 Therefore. It can be understood that the description of the present invention contained in this article ye I 1 has a seal with respect to such as percutaneous transarterial penetration, the device of the present invention 2 0 still 1 1 has a variety of applications or uses 〇As used herein, the term " gel-like " 1 I means a substance with a viscosity of a wide range of 1 1 such as a slightly viscous substance, suspension glue or paste etc. 〇 1 1 -1 2_ 1 1 1 1 This paper scale is applicable to Chinese national standards CNS) A4 specification (21 OX297 mm) 7 A7 B7 Printed by the Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy 5. Description of invention (t () 1 1 Before describing the overall device 2 1 3, outline a typical Knowing blood 1 1 tube surgical procedures, such as a catheter 1 I device that uses a percutaneous incision or puncture, will give the device 20 the best understanding. In this procedure, a ✓— *. Please insert a cannula such as a needle (not shown) such as vascular radiography through the first reading 1 I reading 1 skin M into the artery such as thigh artery 24 For the position where the device is expected to be inserted into the back of δτ 1 I, the intubation needle is kept in position and a mini- 1 1 guid lewire, the flexible end (not shown) is then passed through the cannula Advance 1 I then 1 I into the desired depth of the artery (ie, position along the longitudinal axis there), fill 1 Once the labyrinth lead is positioned, remove the intubation needle and leave the The guide wire writes page 1 there, then, a sheath of a conventional introducer 26 and an arterial dilator 1 1 (not shown) pass the guide wire through the pinhole 28 and enter the artery 24, then , 1 | Remove the guide wire and the dilator leaving the sheath 26 there, connect the cistern, the catheter 1 1 (not shown) or other intravascular instruments are inserted through the sheath 26 of the introducer and 1 Penetrate the artery to the desired intravascular position, for example, atherosclerotic artery | Occlusion position. Once the procedure in the vessel is completed, the catheter or instrument 1 1 is removed. Then, the sheath can be removed 26 And the surgeon or other familiar 1 | Professionals first ·> j ,. The artificial pressure required to perforate the perforated needle hole line 1 until hemostasis takes effect. In many patients, this requires at least 30 minutes for 1 1 pressure 〇-1 I Generally speaking, the device 20 of the present invention can achieve percutaneous or other forms of pinholes, incisions or openings in arteries, other body catheters 1 1 tubes or tongue veins 1 1 Bloody closed without applying artificial pressure to the place. Therefore, once the catheter 1 I or other intravascular device is removed, but preferably, the sheath 26 remains there. 1 1 The device 20 of the present invention can be inserted into the artery 24 through the sheath 26 and operate 1 I is to push the closure or fixator member 30 (described later) into the artery, 1 I -1 3-I 1 1 This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) V. Description of the invention ( —) The large three-piece structure fixes the connection to the 8-hole needle, A7 B7, and the wall blood tube blood port is adjacent to the lead. The lead is closed and the seal is placed temporarily. Less probable hemostasis or / and gel-like tiling 1 and the hole needle should be used to fix the g, after cutting? Shot: the needle is taken away and the sealed material is moved and sealed to make it in place. The device is inserted and inserted.
他 其 或 P 於 由 0 流 液 之 Π 凝期 與週 30間 件時 構之 器短 開定對 上 如 固 之 述 描 膠 相 在 織 組 之 圍 二 文由 0 二 偽 地 tta. tt 榑佳 結較 的質 們物 它狀 收 吸 以 予 内 定 固 該 述 描 加 詳 步一 進 9 至 1± 圖 照 參 現 件 式 形 佳 較窄 之i, ο 薄 U 對 相 種1 含 包 可 件 構 或 分 成 之 器 定 固 該 如 諸 質 物 之 條 長 由售He or P is set by the coagulation period of 0 fluids and the period of 30 weeks. The device is set to be short as described above. The glue phase is described in the surroundings of the weaving group. The two texts are from 0 two pseudo to tta. Tt 榑The quality of the good results is absorbed by the shape to be fixed in advance. The description is described in detail. Step 9 to 1 ±. According to the reference, the shape is better and narrower. Ο Thin U pairs of phases 1 A piece or a device divided into pieces that fixes the length of such things as sold by
ο P Θ d 件 構 器 定 固 該 類ED使 酯彳— 交 之 收 吸 可 ei 種 以的 nc硬 I剛 S 夠 Ur足 H10俱 ，販 物計 合設 聚標 類商 B 酯 R 酷so 脈 33 於 置 被 旦 以 的 折 曲 易 或 的 因曲 及撓 彎可 折夠 其足 除傜 排且 形口 變切 其或 止孔 阻針 可之 時入 中引 導 先大 原 其 穿 回 而 彎 折 織 組 之 脈 該 及 傷 會 不 而 狀 形 之 部 内 脈 33 該 著 順地 地佳 致較 件 奪 榻 器 定 固 該 約 大 値一 少 至 含 包 分 部 體 主 之 構 絲 維 纖 之 分 部一 且 孔 開 之 點 中 之 〇 30伸 件延 構而 器它 定過 固透 該可 於36 位件 (請先閲讀背面之注意事項再填寫本頁) 裝· 訂 線 經濟部中央標準局員工消費合作社印製 -之 件32 構體 之狀 張管 擴該 可於 或配 開裝 展以 可綴 種精 一 夠 為足 可傜 亦時 ο I 3 縮 件壓 構或 器縮 定收 固當 該中 其 以固 中態該 部形上 内之致 體 狀 管 由 當 出 釋 致以 大可 'ο 合 3 閉件 於構 用器 適定 大 放 一 此 至因 開 〇 展28 或孔 張針 擴之與 可脈性 它動彈 Bf該種 大形 ’質 物 性 血 止 或 本紙張尺度適用中國國家標準（CNS〉A4規格（210X297公釐） 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（η ) 成，較佳地偽可生物降解與/或可再吸收之物質，以使其 在病人體内經一相對短的時間週期後被吸收。一種用於 該固定器構件30之另一形式之有潛力有效之物質可為一 種由Johnson & Johnson, Inc·以GELF0AM名字所販售之 多孔的止血可吸收明膠》 較佳地，該纖維絲構件36構成一細長可撓曲之線，以一 種長且細，可生物降解之物質形成，諸如可吸收之缝線， 且較佳地牢固地結合於該固定器構件30之近端側或表面。 此外，較佳地，如圖3中之所示，該纖維絲構件36亦可包含 一撐縮停止構件43於其上，該撐縮停止構件43較佳地傜 一金屬構件，固定地附於該纖維絲構件36自該固定器構 件30—預定距離處。雖然於此描述之雜維絲構件36為一 細長可撓曲構件，但應可理解的俗一種半剛硬或其他合 用之構件亦可使用為纖維絲構件，只要固定器構件因而 可牢固地結合以及凝膠狀物質能連接或銜接該纖維絲構 件以阻塞經該切口，針孔或其他開口之液流。 於本發明之較佳形式中，較佳地，該纖維絲構件係長且 細；以及，因而當炷塞構件38開動將固定器構件30推出 於遠側端出口 34時，該纖雒絲構件36並不會干擾該柱塞 構件38之作業，下文中將較完整地描述。而且，該柱塞構 件38與/或部分之纖維絲構件36可修飾以供給該纖維絲 構件36之所期望厚度與形狀相符於該纖維絲構件36通過 管狀體32之通道路徑。因，此當固定器30推進動脈内時， 該纖維絲構件36沿箸或透過該柱塞構件38滑出該管狀體 -1 5 - 本紙張尺度適用中國國家標準（CNS > A4規格（210X297公釐） 裝 訂 線 (請先閱讀背面之注意事項再填寫本頁) 五、發明説明（4 ) A7 B7 外 長鞸 夠側 足近 係之 6 ο 3 2 件置 構裝 絲於 維·伸 纖延 該分 。部 32質 使 面 實構 之器 6 3 定 件固 構該 絲在 維至 纖甚 該. 撤 Ρ 切 該 自 2 3 0 狀 管 該 使 以 内 脈 於 位 定 地 當 商 被後 30之 件出 谶 該 0 力 張 用 應 之 6 3 件 構 絲 維 纖 該 擾 干 會 不 亦 件 構 器 定 固之 該望 與期 6 J 3 何 件任 構到 絲達 維而 益 效 械 機 成 達 式 方 ill 種 多 以 可 接 1 逋 之 件 構 器 定 固 該 保 確 以 致 上.一 之壁 6 3 管 件血 構之 絲口 維切 纖該 該接 於鄰 持著 保沿 池π 固件 牢構 器 定 固 該 供 提 及 以 開 展 地 置 地位 致之 一 望 期 如 内 於内 置置 被位 ο 3 之 件壁 構 管 器導 定或 固脈 該管 旦 ， 管 ，血 示於 所接 之鄰 中如 式諸 圖丨 中之 式血 形止 佳為 較地 之佳 明較 發且 本收 於吸 〇 物 中生 口可 切種 該一 入由 注可 可52 52質 質物 物狀 狀膠 膠凝 凝d該 劑物 著之 黏分 素成 維一 纖單 之種 分一 成以 要可 主52 種質 兩物 該狀 含膠 包凝 可該 9 S1 種卜一夕 此 如 諸获 9 質組 物來 來 酯 酸 烯 丙 基 気 如 諸 β , 俗 質亦 化 固 可 且 内 體 串 病 (請先閲讀背面之注意事項再填寫本頁) -裝· 、-=β 成 地 佳 較 病 與 為 成 52種 質一 物成 狀應 膠反 凝液 該體 ,患 孔 針 〇 或 3 口件 切構 該器 速定 加固 以該 36著 件固 構緊 絲壁 維管 纖血 於該 著沿 附及 質以 物血 體止 膠之 似中 線 經濟部中央標準局員工消費合作社印製 原 素 維 纖 1 為 可 分 成 之 佳 較 eI 種 一 第 之 劑 箸 黏 素 維 ΛΚ 4 0 5 該質 物 為 前 用 使 在 或 液 溶 以 可 其 供 來 狀 粉 之 組 f 1 3 被 in 種 應 為 可 分 成 之 佳 較 種 二 第 之 素 維 纖 該 其 提 來 狀 粉 或 液 溶 以 可 中例 口比 切之 該速 入快 注有 被具 述成 所形 文之 下塊 如凝 分素 外 由 佳 較 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 師 醫 質成 物種 素兩 酵該 血使 凝以 維們 纖它 之將 分地 £ -nu 域 K! 等分 此可 含I, ί地 經濟部中央標準局員工消費合作社印製 313517 A7 B7 五、發明説明（K ) 切口中，以使該纖維素原與凝血酵素物質不致混合，直到 它們抵達切口中期望之位置。一種克服該等成分之快速 凝塊形成之問題之方式係透過使用匾8及12中所示之一 種雙柱塞注射器總成33之實例。此型式之注射器總成33 可包今一共用或並列之出口，以確保該等成分不會過早 地混合而可能在使用之前導致凝塊形成於輸液裝置中。 仗用纖維素原舆凝血酵素物質，分別為54與56,相信係有 利的，因為該凝血酵素56藉由一種發酵動作以由該凝血 酵素濃度確定之速率轉換該纖維素原5 4為纖維素。因為， 可變化該纖維素原54與凝血酵素56溶液之相對濃度以增 加或減少凝塊形成之速率以使若相等濃度之纖維素原與 凝血酵素以大約數秒鐘來形成一纖維素凝塊，則較稀濃 度之凝血酵素可仗用於以數分鍾來形成一纖維素凝塊。 現可得自 Scottish National Blood Transfusion Serivice之只用於臨床試驗之一種纖維素封合劑套封中， 該纖維素原54偽提供為一種含225亮克纖維素原與大約 50單位之因子W之冷凍乾燥碎性固體物質《供應用於復 原該纖維素原54之溶媒由具備7.5pH值之20bM Tris緩衝 液組成且含每毫升3〇〇〇激肽釋放酶惰性劑單位之抑肽酶。 該凝血酵素56傜供應為一種含每瓶10001 U之冷凍乾燥碎 性固體，而以含大約4QmM氣化鈣之氛化鈣溶液重組該凝 血酵素。 不論所仗用之纖維素原54與凝血酵素56之相對濃度如 何，應確信本發明係目前所提出之所有止血裝置之一種 -1 7 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） I 11 . I ^ 1111 訂 11 線 (請先閲讀背面之注意事項再填寫本頁) 經濟部中央標準局貝工消費合作社印製 A7 B7 五、發明説明（4 ) 改良，因為凝塊形成之速率可由醫師依需要以及根據包 含各病患需求之多種因子來調整。 上文描述本發明基本零件之較佳形式，而下文傜描述 使用於插入該固定器構件30與凝膠狀物質52於病患體内 其値別期望之位置以封合血管，導管或管脈中之切口，針 孔或開口之多種裝置與方法。假如使用一種單一成分之 凝膠狀物質，該注射器總成33可為習知之單筒注射器33, 且注射技術可同樣地修正。 本發明之基本形式係示於圖1至9中。大致地，本實施 例之裝置2G包含一插入器總成31，其可以一種簡單之輸 液裝置，諸如一種細長管狀體32來組成。該插入器總成 亦可包含一柱塞構件38與之結合。該插入器總成31之管 狀體32與柱塞構件38之組合當作一種相當簡器之裝置以 輸送該固定器構件30至病患體中期望之位置。較佳地， 該注射器總成33包含一對柱塞構件55位於一對分離之管 57中，雖企盼該分離式注射器可使用於注射該等物質進 入切口中，如下文將更完整地作描述，相信多種輸液裝置 可滿足需要以準確地輸送本發明之該等封合零件，而各 輸液裝置間之主要差異俗有關該插入器總成31與該注射 器總成33之複雜性。不論如何選擇插入器總成31與注射 器總成33之組合，重要的是該固定器構件30與凝膠狀物 質52須一致地且可靠地被置於切口，針孔或其他開口中 且沿著病患之向管，導管或管脈，因為極重要的傺該凝膠 狀物質不能被注射入血管當中。 -1 8 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) .裝·ο P Θ d pieces of equipment fix this kind of ED so that esters can be absorbed in exchange for nc hard I can be hardened I just S enough Ur enough for H10, and the sales standard is set up by the standard vendor B ester R cool so Vessel 33 is easy to bend or bend due to bending and flexing. It can flex its foot and remove the row, and the shape of the mouth can be cut or the stopper can stop the needle. The veins of the zigzag group should be damaged, and the internal veins of the part will be shaped. 33 This is a good place to fix it with a piece of tatami. The 〇30 extension piece in the point where the hole is opened is extended and fixed. It can be fixed through 36 pieces (please read the precautions on the back and then fill out this page). Printed by the Bureau Staff Consumer Cooperative-a piece of the 32-piece structure can be expanded at or equipped with a dress-up exhibition, which can be adorned with a fine one, which is enough. I 3 In the solid state, the body-like tube in the solid state is controlled by the body Released so that it can be used to close the closure of the 3 in the configuration of the device is suitable for a large one until the opening of the 28 or the expansion of the hole and the expansion of the pulse and it can move Bf the large shape of the physical property hemostasis Or this paper scale is applicable to the Chinese National Standard (CNS> A4 specification (210X297 mm) printed by the Ministry of Economy Central Standards Bureau employee consumer cooperatives A7 B7 V. Invention description (η), preferably pseudo biodegradable and / or The substance to be reabsorbed so that it can be absorbed in the patient's body after a relatively short period of time. Another form of potentially effective substance used for the fixture member 30 may be a kind of material made by Johnson & Johnson, Inc. Porous hemostatic absorbable gelatin sold under the name GELF0AM. Preferably, the fibrous filament member 36 constitutes an elongated, flexible thread formed of a long, thin, biodegradable substance, such as absorbable The suture, and is preferably firmly connected to the proximal side or surface of the holder member 30. In addition, preferably, as shown in FIG. 3, the fiber wire member 36 may also include a shrinkage stop Member 43 on it, the The stop member 43 is preferably a metal member fixedly attached to the fiber wire member 36 at a predetermined distance from the holder member 30. Although the hybrid wire member 36 described herein is an elongated flexible member, However, it should be understood that a semi-rigid or other suitable member can also be used as a fiber wire member, as long as the holder member can thus be firmly bonded and the gel-like substance can connect or engage the fiber wire member to block the cut , Pinhole or other openings. In a preferred form of the invention, preferably, the fiber wire member is long and thin; and, therefore, when the plug member 38 is actuated to push the retainer member 30 out of the distal end outlet 34, the fiber wire member 36 It will not interfere with the operation of the plunger member 38, which will be described more fully below. Furthermore, the plunger member 38 and / or part of the fiber wire member 36 may be modified to supply the desired thickness and shape of the fiber wire member 36 in accordance with the passage path of the fiber wire member 36 through the tubular body 32. Therefore, when the fixator 30 is advanced into the artery, the fiber wire member 36 slides out of the tubular body along the chopstick or through the plunger member-15-This paper size is applicable to the Chinese National Standard (CNS > A4 specification (210X297 Mm) Binding line (please read the precautions on the back before filling in this page) 5. Description of the invention (4) A7 B7 The outer length is enough for the lateral foot 6 ο 3 2 pieces of structured silk Yuwei · stretch fiber This part. The quality of the part 32 makes the surface of the structure of the device 6 3 fixed pieces of solid wire in the dimension to the fiber should not be. Withdrawing P cut from the 2 3 0 shaped tube should make the inner vein in place when the quotient was 30 The piece is out of the way. The force of 0 should be used. 6 3 pieces of silk fiber. The interference will not be fixed by the piece of equipment. The hope and the period of 6 J. 3 Most of the Chengda type ill types can be fixed with a piece of hardware that can be connected to ensure the security. One wall 6 3 The pipe structure of the blood structure of the wire cut fiber should be connected to the adjacent holding edge π firmware The fixture fixes the need for mentioning to develop the position of the land to a desired period If it is built-in, a piece of wall organizer that is placed at position 3 guides or solidifies the tube, the tube, and the blood are shown in the adjacent neighborhood. Jiaming is more hairy, and it is collected in the raw material of the mouth. It can be cut and seeded by the injection of cocoa 52 and 52. It can be composed of 52 germplasms in two forms, including gelatinous encapsulation. The 9 S1 species can be obtained in the same way as all 9 qualities are obtained to ester allyl protons such as β, and the vulgarity can also be solidified. And endosomal string disease (please read the precautions on the back before filling out this page)-Install ·,-= β Cheng Di Jia Jiao disease and the 52 species of one thing should be glued anticoagulant body, the hole Needle 〇 or 3 pieces of cutting structure, the device is fast and fixed, and the 36 pieces of solid structure tighten the wire wall vascular fibrils to the side of the body. Co-op printed primitive vitamin 1 is better than eI and can be divided into the first素 维 ΛΚ 4 0 5 This substance is used in the former or liquid solution to provide the powder that can be supplied by it. F 1 3 should be divided into the better than the second second prime fiber The powder or liquid dissolve can be compared with the mouth. The fast-injecting fast-injection has a block described in the form of the text, such as lectin, and the paper size is applicable to the Chinese National Standard (CNS) Α4 specification (210X 297 Mm) Division of medicine to form phytohormone, two enzymes, the blood to coagulate and maintain the fiber, it will be divided into local areas.--Nu domain K! Equally, this may contain I, printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 313517 A7 B7 Fifth, the description of invention (K) In the incision, so that the fibrinogen and thrombin substance will not be mixed until they reach the desired position in the incision. One way to overcome the problem of rapid clot formation of these components is through the use of an example of a dual plunger syringe assembly 33 shown in plaques 8 and 12. This type of syringe assembly 33 can include a common or parallel outlet to ensure that the ingredients are not prematurely mixed and may cause clots to form in the infusion set before use. The use of the original cellulose and thrombin substances, 54 and 56, respectively, is believed to be advantageous because the thrombin 56 converts the prothrombin 54 into cellulose at a rate determined by the thrombin concentration through a fermentation action . Because, the relative concentration of the solution of procellulose 54 and thrombin 56 can be changed to increase or decrease the rate of clot formation so that if the same concentration of progenin and thrombin form a cellulose clot in about a few seconds, The dilute concentration of thrombin can be used to form a cellulose clot in a few minutes. Now available from Scottish National Blood Transfusion Serivice in a cellulose sealant sleeve used only in clinical trials. The procellulose 54 is pseudo-provided as a frozen containing 225 gram gram procellulose and approximately 50 units of factor W The dried crushed solid material "the vehicle supplied for the restoration of the procellulose 54 consists of 20 bM Tris buffer with a pH of 7.5 and contains 3,000 kallikrein inert units per ml. The thrombin 56 is supplied as a freeze-dried crushed solid containing 10001 U per bottle, and the thrombin is reconstituted with a solution of calcium chloride containing approximately 4QmM vaporized calcium. Regardless of the relative concentration of pro-cellulose 54 and thrombin 56 used, it should be believed that the present invention is one of all the hemostatic devices currently proposed -1 7-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 Mm) I 11. I ^ 1111 Set 11 lines (please read the notes on the back before filling in this page) A7 B7 printed by the Beigong Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 5. Description of the invention (4) Improvement due to clot The rate of formation can be adjusted by the physician as needed and according to various factors including the needs of each patient. The above describes the preferred form of the basic parts of the present invention, and the following description describes the use of inserting the fixation member 30 and the gel-like substance 52 in the patient at their desired locations to seal blood vessels, catheters or vessels Various devices and methods for incisions, pinholes or openings. If a single-component gel-like substance is used, the syringe assembly 33 can be a conventional single-barrel syringe 33, and the injection technique can be similarly modified. The basic form of the invention is shown in Figures 1-9. Roughly, the device 2G of this embodiment includes an inserter assembly 31, which may be composed of a simple infusion device such as an elongated tubular body 32. The inserter assembly may also include a plunger member 38 associated therewith. The combination of the tubular body 32 of the inserter assembly 31 and the plunger member 38 serves as a relatively simple device to deliver the holder member 30 to the desired location in the patient. Preferably, the syringe assembly 33 includes a pair of plunger members 55 located in a pair of separate tubes 57, although it is expected that the separate syringe can be used to inject such substances into the incision, as will be described more fully below It is believed that a variety of infusion devices can meet the need to accurately deliver the sealing parts of the present invention, and the main difference between the infusion devices is related to the complexity of the inserter assembly 31 and the syringe assembly 33. Regardless of the choice of the combination of the inserter assembly 31 and the syringe assembly 33, it is important that the holder member 30 and the gel-like substance 52 be consistently and reliably placed in the incision, pinhole or other opening and along The patient's tube, catheter or vein, because the very important Ye can not be injected into the blood vessel. -1 8-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297mm) (please read the precautions on the back before filling this page).
.1T 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（·7 ) 圖〗係圖示本發明之插入器總成31之一基形成。較佳 地，該插入器總成31包含：一簡單之管狀體32,具備一出 口 34於其遠倒處；以及一柱塞構件38,配置於該管狀體32 中。該管狀體32偽一細長管狀構件且較佳地具備一相當 小的外徑，例如，在大約6至14french (註小口徑測量單 位，約1/3ιηπ)之範圍内，以及以一種多多少少可撓曲之物 質，諸如一種聚乙二醇或聚氣乙烯形成，以允許該管 '状體 32可透過導引器之鞘26插入於動脈24中，或在該導引器 之鞘26已移開後透過該切口插入於動脈24中。如圖2中之 所示，較佳地，當該管狀體32完全插入其中時，該管狀體 32之長度足以置放該管狀體32之出口臨接或稍徹超過該 導引器之鞘26之遠側端。 基本上，該柱塞構件38包含一種簡單細長似圓柱體構 件，具備一種相當平之遠側端於其上。如該管狀體3 2，該 柱塞構件38亦以一種相對可撓曲之物質，諸如聚乙二醇 或聚氣乙烯形成，且大小可配置於該管狀體32之内部中。 該柱塞構件38之外徑稍微小於該管狀體32之内徑，使該 柱塞構件38可人為地沿該管狀體32之縱軸移動，且推擠 或施力使該固定器構件30離開遠側之出口 34以允許該纖 維絲構件36通過其間。所以，如圖2中之所示，該柱塞構 件38傜安排自一撤回之位置至一延伸之置（圖3)，其中 該柱塞構件3 8之遠側端3 9傜位於鄰接該管狀體3 2之遠侧 出口 34。當該柱塞構件38被移至該延伸位置時，該柱塞 構件38之遠側端施力使該固定器構件30離開出口 34且進 -19- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） ----------1------、玎------0 (請先閱讀背面之注意事項再填寫本頁) 五、發明説明（《S ) 下 如 述 A7 B7 佳 最 得 可 9 至 11 圖 照 參 缅 UI- 遠 0 業 作 佳 較 之 例 施 中實 脈明 動發 於本 入 管 該 使 以 6 2 鞘 之 器 引 導 入 -t J 插 可 ο 2 置 裝 地 始 初 0 解 m: 理 之 管 血 之 患 I 病OBT 入 進 且 8 ·, 2 後 孔然 針 〇 或示 口所 切中 過 透 伸 延中 32脈 體管 狀或 圖 如 置 裝 管2£ 導鞘 ’該 接 連 由 ί 鞘 氏該 厄至 路定 之固 線來 穿48 扣圔 鎖如 扣端 鎖側 氏近 厄之 路32 之體 32狀 體管 狀， 管 該 與 示 所 之 中 其文 以下 能如 者o’ 用3 件 使 構 仗 ,(,器 手定 把固 作出 當推 式而 形31 之成 9 Ϊ 4 總 緣器 凸入 狀插 環該 •II Γ\ 種梆 一 緊 〇 以指述 可手所 示 所 之 中 3 吏端 ,ί側 接近 連之 互38 相件 6 I 2 φ 鞘塞 與柱 32該 體下 狀壓 管且 該上 旦搭 一 指 ’姆 其 以 可 著 圖接 如者 用 件 寒 精 塞 柱 5 使 頭作 柱動 緣 凸 之 2 3 體 狀 管 該 抓 緊 而 鞘 該 於 走 滑 此中 〇 其 間’ 之 指 手 其 於 中 向 方 倒 遠 之 内 構構 器塞 定柱 固該 之下 成壓 總32 器體 合狀 閉管 該該 觸向 接朝 39地 端績 側連 遠 。 之位 38部 件側 構近 塞之 柱30 該件 該狀 於管 下達 滑抵 2 9 3 3 口端 出側 側遠 遠之 I 8 向 3 朝件 30構 件塞 構柱 器該 定於 固 。 該部 於内 力之 施32 以體 8 3 狀 件管 音 聲 (請先閲讀背面之注意事項再填寫本頁) .裝. 訂 線 經濟部中央標準局員工消費合作社印製 指 以 ，生 34産 Π丨 出 側 遠 之置 32裝 體知 示 圖 未 Ρ 出 侧 遠中 之部 2 J 3 内 體之 圖 如 習 一 任 是 乎 幾 I 3 由 件 構 ?塞 號柱 信該 ,示 狀 管 該 過 透 已 脈 動 入 進 且 ο 3 件 構 器 定 固 該 。 出示 推所 而之 4 1 3 中 4 之形入 瓣而插 花邊用 似周使 多之當 許 3 們 含體它 包狀過 3 管透 口該’ 出嬈 側圍 遠地 之隔 32間 體距 狀等 管1’ 該5 Ρ 出 侧 遠 或 閘 Ρ 開 51可 部向 地出方 佳突單 較曲一 彎成 本纸張尺度適用中國國家標準（CNS ) Α4規格（210X29*7公釐） 〇13〇l 7 A7 B7 五、發明説明（β ) 出 推 被 可 ο 3 件 構 器 定 固 中脈 昵il °-g33 動於 該空 入懸 進持 且保 出30 推件 被構 34器 口定 出固 時倒該 31遠許 成經允 總30由 器件藉 構可 器者 定用 固使 該則 旦， 數 中 以 鐘 體 狀 管 該 與 著30 接件 寒 0 構 化器 軟定 微固 稍該 件引 構牽 器以 定36 固件 該構 許絲 允維 纖 該 抓 緊 可 者 用 使 側 遠 之 5J . G 賴' 3 .該件 取構 抽器 起定 一 固 可該 者到 用直 使o’ ， 3 後件 然構 。器 示定 所固 之該 中及e S 二 4 3 狀 口 管 出該 脈 或Φ ^ 0^ ^ 0 8活 2 细 ?L$DB$ 針帛力 該1壓 K ^ ^ 溝 接 0^0 0 ^ - 觸，加 接著施 壁 彈 似 類 牟 構 接 件 。 構一不㈣帛 之 2 固Ψ ^ 0 6 料 圖構 如簧 持 保 來 該26 ’鞘 該 使 以 間 圖虜 如皮 〇 人 中病 置與 S43 /1 4 望動 期制 之縮 壁摺 24於 脈置 動可 該62 接件 鄰構 於簧 30彈 示 所 之 中 (請先閲讀背面之注意事項再填寫本頁) •裝· 件 構 器 定 固 該 於 對 43 相 可 3 動 體移 狀式 管合 與組 作 ο 3 件 構 素 維 缴 與 該 於 ο 置 位 之 ο 3 件 構 器 定 固 該 變 改 會 不 而 件 構 狀 點管 此與 6 之26 中鞘 序該 程回 抽 徹 稍 ο 3 件 構 器 定 固 該 於 對 相 地 望 基 可 P 出 側 遠 之 2 3 件 構 狀 管 該 使 以 管 血 近 鄰 入 進 回 抽 徹 稍 且 it 離 距 短 1 開 分 件。 構中 器口 定切 固該 該之 與壁 訂 線 經濟部中央標準局員工消费合作社印裝 Q 切 合 封 脈開 動移 該32 過體 透狀 地管 時自 暫可 ο 8 3 3 件件 構構 器塞 定柱 固該 該 J ，後 置然 位 0 此流 於血 之 著 接 且 成 總 器 射 注 一 地 入佳 插較 體 狀 管 該 於 成 總 器 射 注 該 示 所 中5 7 件 圖構 如塞 。柱 成之 總排 器並 成 組 中 示 所 之 中 射 注 塞 柱 雙 圖之 如知 ，習 上 致 大 對之 一 別 由値 3' 3 於 成動 總移 器係 射件 .11 一 id 精 該塞 ，柱 等 該 地 致 大 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明 ( ^0 ) 1 1 管 室 5 7中 而 進 入 一 共 用 之 出 Π 5 9中 ，其中該注 射器 總成3 3 1 1 之 管 室 57容 纳 經 再 設 定 之 m 維 素與 凝血酵素 ,54與 56，之 1 1 物 質 〇 如 画 7中之F 开示 該 注 射 器總 成33之尺- 寸適合沿著 請 1 1 管 狀 體 32之 長 度 延 伸 以 使 該 注 射器 總成33之 ϋ □ Ε >9延伸 先 閱 1 I 讀 1 1 稍 徹 超 過 該 管 狀 體 3 1 之 出 3 4 〇 背- © 1 I 之 1 一 旦 該 注 射 器 總 成 3 ί 適 切 地 置於 該管狀體： 32中 使用 注 意 I 者 可 同 時 地 壓 下 該 注 射 器 總 成 33之 柱塞構件55以從該處 事 項 1 | 再 ! I 射 出 纖 維 素 與 凝 血 酵 素 物 質 ，54與56。當該纖 維素 與凝 導 1 本 裝 血 酵 素 物 質 ，54 與 5 6， 從 它 們 各 自之 管室57射出進入切口 頁 1 時 ，它們會在該柱射器總成3 3之出口 59—起混 Λ α 〇 1 1 如 圖 8與9 中 之 所 示 ，該纖雒素與凝血酵素物 質從 注射 1 I 器 總 成 3 3射 進 切 P 之 遠 側 部 位 及固 定器構件〔 ! 0之近側而 1 1 訂 1 形 成 一 凝 膠 狀 物 質 5 2之 體 塊 0 該凝 膠狀物質5 2像置於切 P 靠 近 該 固 定 器 構 件 3 0與 /或血管壁。當該纖 維素 與凝 1 I 血 酵 素 物 質 ,5 4與5 6 , g 該 注 射 器總 成3 3射出時，可 令人 1 1 滿 -r-r 地 逐 漸 從 該 切 口 28 撤 出 該 鞘26與管狀體3 2以沿著該 1 | 切 Π 28之 區 域 散 布 凝 膠 狀 物 質 5 2 〇 此外，固為 切口 延伸 線 | 透 過 血 管 壁 與 其 他 經 皮 或 皮 下 組織 ，故當該注 射器 總成 - 1 1 回 縮 時 ，沿著該切口之組織具有收狹或閉合之 傾向 〇血 - 1 I 管 壁 係 由 相. 類 似 於 肌 肉 組 織 之 組織 形成，因而 ，血管壁之 1 1 I 收 狹 較 快 於 該 切 □ 之 剩 餘 部 分 〇因 此，該組織 層之 收狹 1 1 與 該 固 定 器 構 件 3 0 ?兌 著 血 管 壁 之定 位結合以防止該纖維 1 I 素 與 凝 血 酵 素 物 質 進 入 病 人 之 血管 。雖然當凝膠狀物質 1 1 5 2被 注 射 時 ，該鞘2 6與管出 ί體3 2之逐漸撤出傜 令人 滿意 1 1 2 2 1 1 1 1 本紙張尺度適用中國國家標準（CNS > A4規格（210X297公釐） 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（W ) 的，但確信其並非本實施例適當作業之一要件，而是須依 賴若干因素，包含該纖維素與凝血酵素物質之相對濃度 以及注射進入該切口之凝膠狀物質52之量。亦可令人滿 意地留下該鞘26與管狀體32於該切口 28中一短時間週期， 以允許該凝膠狀物質52在該切口由該鞘26與管狀構件32 之撒出之干擾前即開始硬化，如下文之較完整之描述。 最後，當使用者確定在該切口 2 8卞以及沿著該纖維絲構 件36已形成足夠之封合，則該彈秃構件62可自該纖維絲 構件36釋出且自病患之皮虜移開。接著，該鞘26與管狀 體32可完全自該切口移開，而延伸超過病患皮慮之部分 織維絲構件36可予以切除，留下由該凝膠狀物質52,固定 器構件3G以及纖維絲構件36所封合之切口，如画9中所示。 當該凝膠狀物質52硬化且在切口中形成一凝塊，該凝 膠狀物質52摩擦地銜接該纖維絲構件36以確保該固定器 構件3 0被保持於沿著該血管壁。此外，由凝膠狀物質5 2 所形成之凝塊將吸收從該切口 28周圍之組織之任何出血 且亦將吸收任何經該固定器構件30滲出之血液。經其後 之數週，該凝膠狀物質52,纖維絲構件36及固定器構件30 將被吸收於病患之組織内。 該固定器構件30之作用為確保没有凝膠狀物質52進入 動脈且亦確炱該凝膠狀物質52有機會硬化而無大量之血 液或其他流體立即地稀釋該纖維素與凝血酵素物質。因 為該凝膠狀物質52係設計為形成凝塊，極重要的僳該凝 膠狀物質不被注射或另外釋出進入病患之血管中。一研 -2 3 - 本紙張尺度適用中國國家標準（CNS ) A4規格（2丨OX297公釐）. — .I I I I I I I __ 裝 1 I I I I 訂 I ~線 (請先閲讀背面之注意事項再填寫本頁) 經濟部中央標準局員工消費合作社印製 °!S〇i7 A7 B7 五、發明説明（》) 討具有大致如文所逑型式之固定器構件30之止血裝置之 超音波圖K描繪在復原過程中之初始步驟包含沿血管壁 之該固定器構件30之包圍。因此，可確信以本發明，可限 制病患在該最初切口後之短時間形成另一靠近或在先前 切口處之切口，因為該凝膠狀物質可相當快地被吸收，且 可確信該凝塊在完全被吸數若再行穿剌時不會有相反之 影響。為便利病患再穿刖，該固定器構件30與/或該凝膠 狀物質52亦可包含一種放射阻射物質（rdiopaque material)於其中以協助使用者辨識先前切口 28之位置。 圖10至12係描述本發明一進一步之實施例，其中相同 之數字被加至相同之構件以描述各個實施例間之相似處β 於此實施例中，該管狀構件32包含一個或多個沿其近側 端之側邊開口或通口 6 4以及一止血閥6 5於其近側端處。 如圖10中之所示，初始地，該固定器構件30係以上述相對 於先前實施例且示於圖1至7中之方式展開。該管狀體32 之側邊通口 64俗與一出口 66流通連繫，該出口像位於該 管狀體32之内部，如圖11中之最佳顯示。接著，該柱塞構 件38在該管狀構件32中被縮回至一位置於該管狀體32之 内表面近側出口處。然後，使用者以一種示於圔11中之 方式連接該注射器總成33至該側邊通口 64。若使用習知 之單一管室注射器，則可令人滿意於使用多側邊通口以 仗該凝血酵素與纖維素物質，54與56,直到注射進入該切 口 28才混合。於所示之實施例中，該雙管室注射器總成33 包含經再設定之凝血酵素與纖維素物質，54與56,於其中。 -2 4 _ 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公嫠） 裝 訂 線 (請先閲讀背面之注意事項再填寫本頁).1T Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs A7 B7 V. Description of the invention (· 7) Fig. 1 shows the formation of one base of the inserter assembly 31 of the present invention. Preferably, the inserter assembly 31 includes: a simple tubular body 32 provided with an outlet 34 at its far fall; and a plunger member 38 disposed in the tubular body 32. The tubular body 32 is a pseudo-elongated tubular member and preferably has a relatively small outer diameter, for example, in the range of about 6 to 14 french (note small-diameter measurement unit, about 1 / 3ιηπ), and more or less A flexible material, such as a polyethylene glycol or polyethylene gas, is formed to allow the tube 32 to be inserted into the artery 24 through the introducer sheath 26, or in the introducer sheath 26 After removal, it is inserted into the artery 24 through the incision. As shown in FIG. 2, preferably, when the tubular body 32 is fully inserted therein, the length of the tubular body 32 is sufficient to place the outlet of the tubular body 32 abutting or slightly exceeding the sheath 26 of the introducer The far end. Basically, the plunger member 38 comprises a simple elongated cylindrical member having a relatively flat distal end thereon. Like the tubular body 32, the plunger member 38 is also formed of a relatively flexible substance, such as polyethylene glycol or polyethylene gas, and can be sized in the interior of the tubular body 32. The outer diameter of the plunger member 38 is slightly smaller than the inner diameter of the tubular body 32, so that the plunger member 38 can be moved artificially along the longitudinal axis of the tubular body 32, and the holder member 30 is pushed away by pushing or applying force The distal outlet 34 allows the fiber filament member 36 to pass therebetween. Therefore, as shown in FIG. 2, the plunger member 38 is arranged from an withdrawn position to an extended position (FIG. 3), wherein the distal end 39 of the plunger member 38 is located adjacent to the tubular The distal outlet 34 of the body 3 2. When the plunger member 38 is moved to the extended position, the distal end of the plunger member 38 exerts force to move the retainer member 30 away from the outlet 34 and into -19- This paper scale is applicable to the Chinese National Standard (CNS) A4 Specifications (210X297mm) ---------- 1 ------, 玎 ------ 0 (Please read the precautions on the back before filling in this page) V. Description of invention ( "S) As described below A7 B7 Jiadedeke 9 to 11 Picture according to the reference UI- Yuan 0 as a good example of the case Shi Shizhen pulse pulse is issued in this inlet tube should be guided by a 6 2 sheath- t J 插 可 ο 2 Place of installation at the beginning 0 Solution m: Management of the blood tube I disease OBT into and 8 ·, 2 After the hole is needle or the port is cut through the translucent extension 32 vein tube or The picture shows the installation tube 2. The guide sheath is connected from the sheath of the sheath to the road to pass through the 48 buckle lock, such as the buckle end lock side near the road 32. The body 32 is shaped like a tube. The text in the display below can be constructed as 3 with the same as o ', (, the hand will be fixed as a push type and the shape is 31 into 9 Ϊ 4 total edge convex Inserted into the ring • II Γ \ This clasp is tight. It refers to the three terminals at the end, which are close to each other. The 38 phase pieces 6 I 2 φ Sheath plug and post 32 Press the tube and put a finger on it, so you can connect it with a cold pin plug 5 to make the head move as a convex edge of the body. 2 3 The body tube should be grasped and the sheath should be slipped. In the meantime, it refers to the internal structure plug plug fixed in the middle to the far side, which is fixed under the pressure to form a total of 32 bodies, and the closed pipe is closed to the contact side toward the 39 side of the performance side. The 38 parts The side structure is near the column 30 of the plug. This piece should slide under the tube to reach 2 9 3 3. The outlet side is far from the I 8 direction. 3 toward the piece 30. The component 30. The column structure of the plug should be fixed. Shi 32 Body 8 3 shaped tube sound (please read the notes on the back before filling out this page). Install. Printed by the Consumer Cooperative of the Central Standardization Bureau of the Ministry of Economic Affairs, producing 34 products. The figure of the 32 installed body is not shown. The distal part of the side 2 J 3 The picture of the inner body is as usual Any one of them is determined by the number of pieces of I 3 that the plug column believes, the indicator tube has penetrated into the pulse and the 3 pieces of structure fix it. Show the push 4 1 3 in the shape of 4 into the petals and insert the lace with a seemingly persuasive assemblage 3 they contain the body it wraps through 3 tubes through the mouth of the 'separation of the side wall of the remote 32 spaces Shaped waiting tube 1 'The 5 Ρ exit side is far or the gate is open 51 can be partly out of the way. Fang Jiatu is a single bend. The paper size is applicable to the Chinese National Standard (CNS) Α4 specification (210X29 * 7mm). 〇 13〇l 7 A7 B7 Fifth, the invention description (β) can be pushed out ο 3 pieces of the device to fix the middle pulse il il-g33 move in the air suspension suspension and keep out 30 push pieces by the structure 34 device When the solid is poured, the 31 is far away, and the total is 30. The device can be used by the device or the device to use the solid device to make the rule. In the number, the bell-shaped tube should be used with the 30 connector. The piece pulls the retractor to fix 36 pieces of firmware, which allows the wire to allow the fiber to be grasped and can be used at a distance of 5J. G Lai '3. The piece is taken from the structure and the puller can be fixed to use straight o' , 3 afterwards. The device is fixed by the middle and e S two 4 3 shaped mouth tube out of the vein or Φ ^ 0 ^ ^ 0 8 live 2 fine? L $ DB $ Needle silk force the 1 pressure K ^ ^ Groove connection 0 ^ 0 0 ^-Touch, add and then resemble a wall-like connector. The structure of a piece of silk is 2 solid Ψ ^ 0 6 The material is structured like a spring, and the 26 'sheath should be used as a figure between the disease and S43 / 1 4. 24. When the pulse moves, the 62 connector is adjacent to the spring 30 spring display (please read the precautions on the back and then fill out this page). • The mounting device should be fixed to the 43 phase 3 movable body. Movable tube assembly and assembly ο 3 pieces of structural elements to maintain and ο set in position ο 3 pieces of equipment to fix the change will change the shape of the pipe and the 6 of 26 Back to draw a little ο 3 pieces of structure should be fixed to the opposite side of the base. P 2 out of the 3 pieces of the configuration tube should be used to draw blood into the nearest neighbor and pull back a little and it is 1 minute away from the distance Pieces. The structure of the device is fixed and fixed. It should be printed with the wall of the line and the Ministry of Economic Affairs Central Standards Bureau Employee Consumer Cooperative. Q-sealed sealing pulse is moved. The 32 through-body ground tube is temporarily available. 8 3 3 piece structure Plug the column to fix the J, and then set it to 0. This is the connection of the blood and the injection of the totalizer into the body-shaped tube. The injection of the plug into the body is 5 7 pieces in the Institute. Constructed like a plug. The main row of the column is combined with the two pictures of the injection plug in the group shown in the group. As is known, one of the major pairs in the practice is not from 3 '3 to the moving total shifter. 11 a id Refine the plugs, pillars and other large-scale papers in this area. Applicable to the Chinese National Standard (CNS) A4 (210X297 mm) A7 B7 Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Invention Instructions (^ 0) 1 1 tube The chamber 57 enters a common outlet Π 5 9 in which the syringe assembly 3 3 1 1 of the tube chamber 57 contains the re-set m-dimensional and thrombin, 54 and 56, the 1 1 substance. F in picture 7 shows the size of the syringe assembly 33-the size is suitable to extend along the length of the tubular body 32 so that the syringe assembly 33 is ϋ □ Ε > 9 extension first read 1 I read 1 1 Slightly past the tubular body 3 1 out 3 4 〇 back-© 1 I of 1 Once the syringe assembly 3 ί is properly placed in the tubular body: 32 use note I can press the plunger member 55 of the injector assembly 33 at the same time to project item 1 | again! I eject the fibrin and thrombin substances, 54 and 56. When the cellulose and the coagulation guide 1 are filled with blood enzyme substances, 54 and 56, and are ejected from their respective tube chambers 57 into the cutout page 1, they will mix at the outlet 59 of the column injector assembly 3 3. Λ α 〇1 1 As shown in FIGS. 8 and 9, the fibronectin and thrombin substances are injected from the injection 1 I device assembly 3 3 into the distal part of the cut P and the fixation member [! Near the 0 side The 1 1 order 1 forms a mass of a gel-like substance 5 2. The gel-like substance 52 is placed close to the fixation member 30 and / or the vessel wall. When the cellulose and coagulation 1 I blood enzyme substance, 5 4 and 5 6, g are ejected from the syringe assembly 3 3, it is possible to gradually withdraw the sheath 26 and the tubular body from the incision 28 full-rr 1 1 3 2 Spread the gel-like substance along the area of the 1 | cut Π 28 5 2 〇 In addition, solidified as the incision extension line | through the blood vessel wall and other percutaneous or subcutaneous tissue, so when the syringe assembly-1 1 During contraction, the tissue along the incision has a tendency to narrow or close. The blood-1 I wall is formed by tissues similar to muscle tissue. Therefore, the narrowing of the blood vessel wall 1 1 I is faster than the incision. The remaining part of □ Therefore, the constriction 1 1 of the tissue layer and the fixation member 30 are combined with the positioning of the blood vessel wall to prevent the fibrin 1 I and thrombin substances from entering the patient's blood vessel. Although when the gel-like substance 1 1 5 2 is injected, the sheath 26 and the tube 3 are gradually withdrawn from the body 3 2 is satisfactory 1 1 2 2 1 1 1 1 This paper scale is applicable to the Chinese National Standard (CNS > A4 specification (210X297 mm) A7 B7 printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economy V. The description of invention (W), but it is believed that it is not one of the requirements for proper operation in this embodiment, but depends on several factors, Contains the relative concentration of the cellulose and thrombin substances and the amount of gel-like substance 52 injected into the incision. It is also satisfactory to leave the sheath 26 and the tubular body 32 in the incision 28 for a short period of time, To allow the gel-like substance 52 to start hardening before the incision is disturbed by the sheath 26 and the tubular member 32, as described more fully below. Finally, when the user determines that the incision 28 and A sufficient seal has been formed along the fiber wire member 36, then the bald member 62 can be released from the fiber wire member 36 and removed from the patient's skin. Then, the sheath 26 and the tubular body 32 can be completely Removed from the incision, The portion of the woven silk member 36 that extends beyond the patient's skin can be excised, leaving the incision sealed by the gel-like substance 52, the holder member 3G, and the fiber member 36, as shown in Figure 9. The gel-like substance 52 hardens and forms a clot in the incision, the gel-like substance 52 frictionally engages the fibrous filament member 36 to ensure that the anchor member 30 is held along the vessel wall. In addition, by The clot formed by the gel-like substance 5 2 will absorb any bleeding from the tissue around the incision 28 and will also absorb any blood oozing through the fixture member 30. After several weeks, the gel-like substance 52. The fibrous filament member 36 and the anchor member 30 will be absorbed into the patient's tissue. The role of the anchor member 30 is to ensure that no gel-like substance 52 enters the artery and that the gel-like substance 52 has a chance Harden without a large amount of blood or other fluids immediately dilute the cellulose and thrombin substances. Because the gel-like substance 52 is designed to form a clot, it is very important that the gel-like substance is not injected or otherwise released Enter the patient's blood vessel.一 研 -2 3-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (2 丨 OX297mm). — .IIIIIII __ Pack 1 IIII Order I ~ line (please read the precautions on the back before filling this page) Printed by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs ° S〇i7 A7 B7 V. Description of the Invention (》) Discussing the ultrasonic chart K of the hemostatic device with the holder member 30 of the type as described in the text depicting the recovery process The initial step includes the surrounding of the fixator member 30 along the vessel wall. Therefore, it is believed that with the present invention, the patient can be restricted from making another incision near or at the previous incision shortly after the initial incision, because the The gel-like substance can be absorbed quite quickly, and it is believed that the clot will not have the opposite effect when it is completely absorbed and then punctured again. In order to facilitate patient reattachment, the fixture member 30 and / or the gel-like substance 52 may also include a radio-opaque substance (rdiopaque material) therein to assist the user to identify the location of the previous incision 28. 10 to 12 describe a further embodiment of the present invention, wherein the same number is added to the same member to describe the similarities between the various embodiments. In this embodiment, the tubular member 32 includes one or more edges A lateral opening or port 64 at its proximal end and a hemostatic valve 65 are at its proximal end. As shown in FIG. 10, initially, the holder member 30 is deployed in the manner described above with respect to the previous embodiment and shown in FIGS. 1 to 7. The side port 64 of the tubular body 32 is circulatively connected to an outlet 66 which is located inside the tubular body 32, as best shown in FIG. Next, the plunger member 38 is retracted in the tubular member 32 to be positioned at the outlet near the inner surface of the tubular body 32. Then, the user connects the syringe assembly 33 to the side port 64 in a manner shown in Fig. 11. If a conventional single-barrel syringe is used, it is satisfactory to use a multi-sided port for the thrombin and cellulose material, 54 and 56, until the injection enters the incision 28 before mixing. In the illustrated embodiment, the dual-barrel syringe assembly 33 contains the reprogrammed thrombin and cellulose material, 54 and 56, therein. -2 4 _ This paper size is applicable to China National Standard (CNS) Α4 specification (210X297 gong) binding line (please read the notes on the back before filling this page)
A X /V 明 説 明 發 五 體 狀 管 時該 口入 通射 邊33 側成 該總 至器 接射 連注 被該 3 3 自 成可 總質 器物 射素 注酵 該血 旦凝 一 與 素 維 纖 該 之 血 凝 該 使 可 者 用 仗 所 。中 期12 週圖 間如 時至 短移 一 以 化38 要硬件 需中構 若32塞 。 體柱 中狀之 部管32 内該體 與 酵 後示 然 維壓 纖可 延 之 在狀以 物¾¾¾ 且 孔. 針 之 ο 3 件 榑 器 定 固 該 接 鄰 入 進 2 5 0 質側 物近 狀之 膠壁 凝管 該血 出該 射沿 者含 再包 可 件 構 器 定 固 之 例 施 實 本 示 所 之 中 2 IX 至 ο 1A 圖 如 該 著 沿 ο 3 件 構 器 定 固 該 當 8 6 件 構 部 頭 之 大 加 該 件 構 部 頭 之 大 使 ο 3 件部 構頭 器之 定30 固'件 之構 時式器 置型定 放此固 壁具該 管。於 血伸固 件 構 (請先閱讀背面之注意事項再填寫本頁) .裝· 延凝 内可 I 2 向 5 壁質 管物 血狀 該膠 自凝 傜該 固 牢I 成 形 以 圍 周 之 以 30圍 件周 構之 6 器36 定件 固構 之絲 例維 施纖 實該 前於 先塊 如凝 0 一 中成 孔形 針亦 該52 於質 合物 封狀 之膠 凝 確 同 相 中 。其 壁J 管例 向施 該實 於之 接步 鄰一 持進 保一 地明 固發 牢本 30述 件描 構傜 器15 定至 -,3 固 1 該圖 保 相 至中 加例 被施 字實 數此 之於 處 同 相 之 間 例 施 實 個 各 述 描 以 件 構 之 同 於 示 述 上 於 同 相 偽 上 質 實 2 3 件 構 狀 管 該 訂 經濟部中央標準局員工消費合作社印装 □ 通 或 2 3P 件開 構邊 狀側 管之 之端 中側 12忻 至其 ο , 1 治 圖個 多 或 個1 含 包 2 3 件 構 狀 管 該 閥 血 止1 及 以 其 件 奪 構 器 定 固 該至 地1 “η圖 始拎初W 示且 所例 之施 中實 13前 圖先 如於 。對 處相 端述 側上 近以 中 7 Π , 通部 邊内 側之 之體 32狀 體管 狀該 管於 該位 像 開 展 式 方 之 係 P 出 該 繫 -BE 逋 通 流 P 出1 與 構 塞 柱 該 著 接 0 示 所 之 中 3 iA 圖 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X297公釐） 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（4 ) 件38自該管狀構件32縮回與撤回。然後，使用者以一種 示於圖14中之方式連接該注射器總成33至該側邊通口 64, 而該止血閥65封合該管狀體32近側端。若使用習知之單 一管室注射器，則可令人滿意於使用多側邊通口以使該 凝血酵素與纖維素原物質，54與56,直到注射進入該切口 28才混合。於所示之實施例中，該雙管室注射器總作33 包含經再設定之凝血酵素與纖維素物質，54與56,於其中。 一旦該注射器總成33被連接至該·側邊通口時，該雜維絲 素與凝血酵素物質可自該注射器總成33射入該管狀體3 2 之内部中。然後，使用者可使該凝膠狀物質52在該管狀 體32中硬化一短時間週期以使該凝膠狀物質52摩擦性地 銜接至該纖維絲構件36。當該凝膠狀物質52已開始硬化， 該管狀體32可自該切口撤出以使該凝膠狀物質52以銜接 該纖維絲構件36及鄰接該固定器構件3 Q被定位於切口中。 圖16至18傜描述本發明一進一步之實施例，其中相同 之數字被加至相同之構件以描述各値實施例間之相同處。 於此實施例中，該固定器構件30俗以上述及示於匾1至 7中之方式沿著動脈壁放置，然後，該鞘2 6與該管狀體32 自該針孔移開而只留上該固定器構件30與纖維絲構件36 於該切口與血管中。然後，一相同於上逑彈簧構件之彈 簧構件62被置於該纖維絲構件36之上以保持該固定器構 件沿箸血管壁以及維持一徹量與連續之壓力於該固定器 構件30之上。其次，一修飾之彈簧總成70(圖16)可以圖17 中所示之方式附著於該纖維絲構件36。較佳地，本實施 -2 6 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） — 111 I 1111 Ί 線 1 (請先閱讀背面之注意事項再填寫本頁) 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（Η ) 例之彈簧總成70包含兩個分離之管室72與柱塞構件74與 柱塞構件74於其中以及一共用之出口 76。較佳地，該注 射器總成70之遠側端稍微尖細以及包含一大致呈U型之 夾構件78於其上。該夾構件78傜設計為可滑動地銜接或 夾在該纖維絲構件36之上以使該注射器總成7Q在該切口 中遠侧可移動地沿箸該纖維絲構件36至示於圖18中之位 置，其中該夾構件78接觸固定器構件30。使用該夾構件 78於該注射器總成70之遠側端可確保該注射器總成70與 該纖維絲構件36之間適當的調整，以使當該凝膠狀物質5 2 被注射進入該針孔中時，該凝膠狀物質可包圍該纖雒絲 構件36。因此，當該凝膠狀物質硬化時，該凝膠狀物質52 與該纖維絲構件3 6間之磨擦性的銜接將被確定。此外， 如圖18中之所示，該注射器總成70之出口與夾構件78分 隔一固定距離，以使當該注射器總成70沿著該纖維絲構 件36移動時，該夾構件78將接觸該固定器構件30以停止 該注射器總成7 0之遠側進一步移動。一旦該夾構件7 8到 達固定器構件30時，該出口 76將與固定器構件30分隔期 望之距離，而該凝膠狀物質52可自該注射器總成7G射出 而不會注射該凝膠狀物質52進入病患之血管中。 上逑且示於圔16至18之夾構件與注射器總成之另一形 式係示於圖19至21中。最佳地，如圖20中之所示，較佳地， 該夾構件78傜形為構件其傷與該注射器分離的。於此另 一實施例中，該夾構件78包含一相當小之半圓形遠側端80, 以及一較大之半圓形近側端8 2其大小傺暫時地銜接該注 -2 7 - 本紙張A度適用中國國家標準（CNS ) A4規格（210 X297公釐） I I I I I 裝— I i I I I 訂 線 (請先閱讀背面之注意事項再填寫本頁) 五、發明説明（〃） A7 B7 由 傜 2 8 與 ο 8 端 側 遠 與 側 近 該 0 端 側 遠 之 ο 7 成 總 器 射 之 例 施 實 之 一 另 此 ο 接 a 互 相 4 8 件 構 之 膠周 凝之 該78 使件 以構 成夾 形該 質於 物化 收硬 吸使 物且 生中 可 口 種切 于入 以進 體慮射 長考注 細可可 為7852 上件質 致構物 大夾狀 圍移飾 可 成 總 器 射 注 化 硬 始 開 2 5 質 物 狀 膠 凝 該 旦1 此 因 中 Π 切 該 於 8 7 件 構 夾 下 留 而 開 替 % 接 銜 地 質 實 8 7 件 構 夾 該 使 以 修或 步合 一 接 進式 可簧 例彈 施一 實備 此具 〇如 裝 扣中 鎖例 式施 型實 他此 其於 構 器 定 固 之 置 件 榑 器 射 注 該 當 件 構 部 頭 之m ο 自 ο 7Γ 件 時 開 移□ 切 此構 因夾 。該 件作 構70 器成 定總 固器 該射 與注 以之 且例 釋施， 端實* 側此 遠 C 之中 ο ]. 7π 成切 總該 器於 射留 注保 該而 自接 78銜 件 3 成 總 器 中射 口注 切該 於保 78確 件以 構件 夾隔 該間 位一 定為 以用 件作 構78 位件 定構 1 夾 為之 用例 施 實 此 而 之 (請先閱讀背面之注意事項再填寫本頁) .裝· 訂 分 30況 件情 構列 器下 定於 固用 與有 端地 側別 遠特 件 構 夾 之 例 施 實1 另 此 ο 開 線 射 放 用 使 地 意 滿 人 令 可 中 其 辨 來 質 件質 物 二 射,g物 阻如生 之 P 切 以少 慮至 考且 ^ ^ ^ 步^含 * “ Θ §固4 S於8 用1S件 mBS構 MIffli® 位 其 之 血0<放 5J 止 之 件 構 例可 I 種 線 經濟部中央標準局員工消費合作社印製 中目 其注 於人 定引 設地 質別 物特 射 '中 阻78 線 射 放 用 使 件 構 夾 該 於 質 物 壁 管 血 於 放 置 .、.傜 象 8 a 7 件 寒 構 夾 該 為 因 中進 口或 開自 之止 一了 /#1 執 於 .1nB W 從 師 醫 當 域 區 之 心 關 所 師 醫 為 ¾ 隹*' 優1 另 之 件 構 夾 式 it 離 分 可 該 ο 時 序 程 之 步 小件 大構 別夾 個該 之於 82大 端較 側 傷 近82 與端 8fil 端近 側之 遠78 之件 78構 件夾 構該 夾地 該佳 關較 有為 係因 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 五、發明説明（4 ) 縮 收 度 長 之 件 構 〇0 夾 端該 側沿 遠狀 之形 A7 B7 漏 沙 -1 種 1 以 將 織 組 定 固 該 持 維 助 協 步 時一 化進 硬以 2 5 質 物 狀 膠 凝 當 位 之 望 期 所 中 P 切 於 質 物 狀 膠 凝 以 8 7 件 構 夾 ο 3 件 構 器 示§ -ί 明 所 合 0 f 之 U 封 中4使 21解法 圖理方 如應用 致述使 大上的 ，從們 置 它 及中 以織 成組 總式 引腔 導體 與’ 成 總 器 射 注 之 官 器 體 人 如 諸 脈 管 口透 開皮 管他經 血其合 導例穿 0 肝 Π 切 或 孔 針 之 管 之封檢 铲於鏡 形用腔 所使腹 中可或 體法檢 患方鏡 病用節 在使關 或其在 ’及 成 總 合 封 該 止 阻 以 的 0 為 如剌 過椎 透脊 後在 之至 序甚 程或 位 部 刺 穿 臓 肝 著 沿 後 險膜 危腹 之入 膜進 腹液 入汁 進之 汁出 臛漏 之柱 出脊 漏該 (請先閱讀背面之注意事項再填寫本頁) -裝_ 險 危 之 用 使 可 亦 法 方 用 使 其 及 械 器 器 合 之封 序等 程該 且 之 成 造 所 傷 外 他 其. 或 傷 穿 皮 經 由 中 臓 心 或 臓 肝 在 合 。 封口 於切 訂 經濟部中央樣準局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）AX / V clearly shows that when the five-body tube is sent, the mouth enters the shooting edge 33 side into the total device, then the continuous injection is injected by the 3 3 self-contained device. The blood that should be used should be used as a battle place. During the 12-week period of the mid-term, a short shift from time to time is required to change the hardware. In the column-shaped tube 32 of the body column, the body and the fermented fiber can be extended into the shape of the object and the hole. The needle of ο 3 pieces of the container fixed the adjoining into the 2 5 0 qualitative side objects The near-shaped plastic wall coagulation tube The blood out of the shooter contains the case of the re-packageable device and fix it. Implement the 2 IX to ο 1A picture shown in the picture. 8 The 6-piece structural head plus the ambassador of the 3-piece structural head. The 3-piece structural head is fixed with a 30-piece structural device. This fixed wall is fixed with the tube. In the blood extension structure (please read the precautions on the back before filling out this page). Installed in the coagulation can be I 2 to 5 wall tubule bloody. The glue is self-coagulating and the solid I is shaped to take around 30 pieces of the surrounding structure of the 6 devices 36 fixed pieces of solid wire for the application of fiber-strengthening before the first block such as condensate 0 a hole-forming needle and the 52 in the gel seal in the form of the compound is indeed in phase. The wall J tube is to be applied to the next step, and the next step is to keep it in place, and the body is to be fixed. The 30 descriptions of the structure 15 are fixed to-, 3 and 1. The picture is preserved to the middle and the example is applied. The real number is between the same phase and the example is applied. The description is the same as the description. The description is the same on the pseudo phase. The 3 configuration is managed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. Or 2 3P pieces open the end of the side edge of the side tube 12 Xin to its ο, 1 treatment of more or more 1 contains 2 3 pieces of the shape tube The valve is only 1 stop and the structure is determined by its piece It should be fixed to the ground 1 "The η picture is shown at the beginning and the first picture of Shi Zhongshi 13 is the same as the previous picture. The phases are described above and below the side 7 Π, the body on the inner side of the pass 32. The tube is in the position where the image develops. The system is P out of the system-BE through the flow P out 1 and the plug column is connected to the 0. Indication 3 iA The paper size is applicable to the Chinese National Standard (CNS) A4 Specifications (210 X297 mm) Printed by the Employees Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs A 7 B7 5. Description of the invention (4) The piece 38 is retracted and withdrawn from the tubular member 32. Then, the user connects the syringe assembly 33 to the side port 64 in a manner shown in FIG. 14, and the The hemostatic valve 65 seals the proximal end of the tubular body 32. If a conventional single-barrel syringe is used, it may be satisfactory to use a multi-sided port to make the thrombin and cellulosic material, 54 and 56, until The injection enters the incision 28 before mixing. In the embodiment shown, the dual-barrel syringe assembly 33 contains the reprogrammed thrombin and cellulose material, 54 and 56, in it. Once the syringe assembly 33 is When connected to the side opening, the heterovistin and thrombin substances can be injected from the syringe assembly 33 into the interior of the tubular body 32. Then, the user can leave the gel-like substance 52 in The tubular body 32 is hardened for a short period of time to frictionally engage the gel-like substance 52 to the fiber filament member 36. When the gel-like substance 52 has begun to harden, the tubular body 32 can be withdrawn from the incision So that the gel-like substance 52 can connect the fiber filament member 36 and the adjacent The holder member 3 Q is positioned in the cutout. FIGS. 16 to 18 illustrate a further embodiment of the present invention, in which the same numbers are added to the same members to describe the similarities between the various embodiments. In this embodiment In this manner, the fixator member 30 is placed along the artery wall in the manner described above and shown in plaques 1 to 7, and then the sheath 26 and the tubular body 32 are removed from the pinhole leaving only the fixator The member 30 and the fiber wire member 36 are in the incision and the blood vessel. Then, a spring member 62, which is the same as the upper spring member, is placed on the fiber wire member 36 to keep the holder member along the gullet wall and maintain a full and continuous pressure on the holder member 30. Second, a modified spring assembly 70 (FIG. 16) can be attached to the fiber wire member 36 in the manner shown in FIG. Preferably, this implementation-2 6-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) — 111 I 1111 Ί line 1 (please read the precautions on the back before filling this page) Central Ministry of Economic Affairs Printed by the Bureau of Standards and Staff Consumer Cooperative A7 B7 5. The spring assembly 70 of the invention description (H) example includes two separate tube chambers 72 and plunger members 74 and plunger members 74 therein and a common outlet 76. Preferably, the distal end of the injector assembly 70 is slightly tapered and includes a generally U-shaped clip member 78 thereon. The clip member 78 is designed to slidably engage or clip on the fiber wire member 36 so that the syringe assembly 7Q can move along the fiber wire member 36 distally in the incision to the one shown in FIG. 18 Position, where the clip member 78 contacts the holder member 30. Using the clip member 78 at the distal end of the syringe assembly 70 can ensure proper adjustment between the syringe assembly 70 and the fiber filament member 36 so that when the gel-like substance 5 2 is injected into the needle hole When in the middle, the gel-like substance may surround the fiber filament member 36. Therefore, when the gel-like substance hardens, the frictional engagement between the gel-like substance 52 and the fiber filament member 36 will be determined. In addition, as shown in FIG. 18, the outlet of the syringe assembly 70 is separated from the clip member 78 by a fixed distance so that when the syringe assembly 70 moves along the fiber wire member 36, the clip member 78 will contact The retainer member 30 stops further movement of the syringe assembly 70 distally. Once the clip member 78 reaches the holder member 30, the outlet 76 will be separated from the holder member 30 by the desired distance, and the gel-like substance 52 can be ejected from the syringe assembly 7G without injecting the gel-like substance Substance 52 enters the patient's blood vessels. Another form of the clip member and syringe assembly shown above and shown in Figs. 16-18 is shown in Figs. 19-21. Optimally, as shown in FIG. 20, preferably, the clip member 78 is shaped to separate the wound from the syringe. In this other embodiment, the clip member 78 includes a relatively small semicircular distal end 80, and a larger semicircular proximal end 8 2 whose size temporarily connects the note-2 7- The A degree of this paper is applicable to the Chinese National Standard (CNS) A4 specification (210 X297 mm) IIIII Packing-I i III Threading (please read the precautions on the back before filling in this page) 5. Description of the invention (〃) A7 B7 by傜 2 8 and ο 8 end-side far and side close to the 0 end-side far ο 7 The example of the totalizer shot is one of the other implementations ο Connect a to each other 4 8 pieces of glue to congeal the 78 to make the pieces to form a clip shape The quality is hardened by physical and chemical absorption, and the delicious seeds are cut into the body to take into consideration the length of the body. The cocoa is 7852. The upper structure of the mass-shaped structure is a large clip-shaped surrounding decoration. 2 5 The material-like gel should be replaced 1 because it should be left under 8 7 frame clips, and it should be replaced. The 8 7 frame clips should be repaired or stepped into one. This tool is prepared by spring-loading. For example, a lock-in lock-out routine This configuration which is set to the fixed member opposing the shot Bo is the configuration of the head member when the m ο ο 7Γ member from the opening when the shift □ cut due to this configuration folder. This piece is used to construct 70 sets of fixed fixtures. The shots and injections are given and examples are given, and the end of the side is far away from the C.]. Adapter 3 The injection port in the finalizer should be used to ensure that the 78 pieces are separated by the component clips. The space must be constructed with the pieces. 78 pieces are fixed. The 1 clip is used to implement this (please read the back side first Please pay attention to this page and then fill out this page). The installation and ordering is divided into 30 cases, and the case is set to be fixed and fixed at the end. If you are satisfied, you can distinguish between the quality and quality of the object, and the resistance of the g object is as high as possible. P ^ ^ ^ Step ^ contains * "Θ § solid 4 S in 8 Use 1S mBS to construct MIffli ® The blood of its own 0 < 5J pieces can be printed in line with the type I can be printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. The clip should be placed on the wall of the material .. 傜 象 8 a 7 The cold clip should be caused by Imported from China or opened from the end / # 1 is obliged to. 1nB W from the teacher to the heart of the local area, the teacher is ¾ 隹 * '优 1 Another piece of structured it can be divided ο time series The small piece of the large structure clip should be closer to the 82 end of the 82 side and the end of the 8fil. The end 78 is far from the end 78. The 78 piece clip structure is suitable for China because the paper size is suitable for China. National Standard (CNS) A4 specification (210X297mm) V. Description of invention (4) Long-retracted piece structure 〇0 The shape of the side of the clip along the far side A7 B7 Leakage sand-1 type 1 to set the weave To maintain the support and help the co-operation, it will become harder and harder, with 2 5 gelatinous materials in place. P cut in gelatinous materials, with 8 7 pieces. Ο 3 pieces. § -ί Minghe 0 f of the U seal, 4 of 21, and the solution of the graphic method is as big as the application. From them, we will set it up and weave into a group of general cavity conductors and the official device of the totalizer injection. The vascular orifices are opened through the skin tube, and the menstrual blood is guided through the liver. Sealing the shovel of the needle tube in the abdomen of the mirror-shaped cavity can be used in the abdomen or the physical examination of the diseased side of the square mirror is at the gate or in the 'and the total seal of the stop resistance is 0 as if passing the vertebra After the ridge is penetrated, it will be in the order or the location or the location will pierce the liver, along the posterior dangerous membrane, the abdominal membrane, the abdominal fluid, the juice, the juice, the juice, the leaking column, and the spinal leakage. Please fill out this page again) -Install _ Dangerous use can also be used by the French side to make the seal order with the weapon and other procedures should be caused by the damage caused by the other. Or wound through the skin through the heart Or hepatic liver. Sealed by Yu Qiding Printed by the Employee Consumer Cooperative of the Central Prototype Bureau of the Ministry of Economic Affairs This paper standard is applicable to the Chinese National Standard (CNS) A4 (210X297mm)