經濟部中央標準局員工消費合作社印製 297830 at Β7 五、發明説明（1 ) 發明膂景 本申諳案爲1992年10月26日所提出中請之美國專利申請 案序狭966,232之一項部份連續案，其全部内容均併入本 文供麥考。 本發明係«於一種舞隐形瞰親赋予顧色之方法。更明碡 言之，係關於一種製馕親水性單髏舆染科之高度纯化合物 之改良方法。 闢於在欷式隱形隊銳中試予均勻分谦之淺色之罾用方法 ，係描迷於例如美國專利4,468,229中。一般而言，係首 先将銳片浸泡在染科之水溶液中，然後在镅別溶液中，使 该柒科鈷合至鏡片。此嬈片典型上係由一種衍生自說水性 單髏之聚合反應之親水性聚合Λ所鈒成。進行染科對鏡片 之餘合，係在最後水合步驟之翁，藉由核經浸沲之銳片舆 一種含水絵接觸，其係欲在可接受之pH值下，提供具有所 欲水量之软柔水凝膠銳片。 於罾用方法中所使用之染料，典型上係衍生自一種_基 三嗜，例如一種二幽基三啫或單i基三《•井，尤其是水溶性 二氣三喑。例如，蒂有磺酸旅官能基之二氣三。并或單#基 三嗜染料，係可濬於水，因此，鯖合作用必須在最後水合 步騄之贫，舆用以鈑成鏡片之親水性聚合Λ—起進行。否 則，該柒料會在鏡片内聲移，而造成不均勻分散，或濾出 銳片逸入配戴者之睬崎内β 在该鯖合巳形成後，對於使用罾用方法所製成之軟式銳 片虓予淺色之染料，不僅被分散於銳片中，而且不會在銳 本紙張尺度適用中國國家標準（cns )Α4規格（210X297公羡） (請先閲讀背面之注意事項再填寫本頁) -*?τ 城— 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（2 ) 片中聲移成瀘出舰片。該級微染之Λ片，於水性媒質中及 在重複高瀵循環後，於例行》戴及清洗期《所存在之情況 下，亦很安定。此罾用方法需要薅親片浸池在一種含有該 染科之浓液中，其係在一特定濃度下，且係在一特定傳導 性下，以致該染科會獷散至聚舍《中。傳導性係很重要的 ，因爲可藉由遘擇不网鹽濃度，挫制羡片之膨《作用。亦 重要的是，柒料濃度及銳片停留在柒料浸沲液中之時W， 應經精確核制，因擴教動力學會決定《覦微染隱形眼鏡之 彍度。此罾用方法係在柒科洗液中採用高濃度染料，以致 可處躧連續微染作業。很不幸地，此方法是很麻煩的，且 需要多重步騄，尤其是在商業规糢製造上，因其必須在特 定濃度舆時《下，薅鏡片浸泡在柒科濬液中•以遣成染科 於銳片中之分散。因此，由於此項困籌，故巳在辱找替代 方法。 美國專利4,559,059指出，或許可在聚合作用之鎗，薅 一種單《，例如甲基丙蟑酸2-羶基乙醱，舆一種反應性染 料反應，及接著在用以產生被親片之單髖之聚合反應期間 ，聚合該單《染科單位。侬是，此專利並未描迷製備該可 聚合單體-柒科單位所必須之方法以及其反應條件。其中 •質係》蓋從高濃度秦機廬至作爲抗塵劑使用之界面活性 劑。離質鏢爲加工助劑，例如無機贏，以加速柒料之溶解 。添加上迷成份，係因此等染科之主要應用，是針對蝗维 素織物材科之微染》此等添加劑會使該反應性染料在該織 物處瑾上更具功能性。合成鎿質係钆括染料先質及反應則 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） JL,4------訂------成丨 (请先閱读背面之注意事項存填寫本貫) 經濟部中央標準局員工消费合作社印製 A7 _B7_ 五、發明説明（3 ) 產物。此等物質是不活性的，且必須在其可被排放至城市 下水道系统中之前，自生產用水中移除。薅此等染科舆說 水性單殖反應之通常蛣果，是振低產率之單官龈性單髓-柒科單位。因此，本發明之一項目的，係爲提供一種高度 純化之單Λ-染料單位。提供一種製逄覦高度纯化單髓-染料單位之方法，亦爲本發明之一項目的。 關於使用典塑反應以進行使一種染料偶合至一種親水性 單體單位之一項缺點，係來自典琅上用以使隐形睬鏡柒色 之市講可得柒科之#質。 美國專利4,157,892揭示對用以產生銳片之聚合髖添加 一《官能基，此官能基對柒对具有反應性。此種龜官能基 化之聚合«，係簸由蓊一種"僞合劑單髖”舆一種臂用鏡水 性單髏反應而製成。此種供合劑單tt具有改變聚合物物理 性質之高度可能性。薅製自该經官龅基化聚合Λ之銳片， 浸溃在一種重氬廬染料之溶液中，於是染料係於其中錄合 至該聚合«。隼然發生迷當之鯖合作用，忸此方法仍需要 將巳完成之鏡片漫渍在柒料溶液中。 對软式親片竦予籲色之另一種方法，係揭示於美國專利 4,640,805中。此專利係描迷使用寶用旋轉鋳膜技術，製 傭一種級微染鏡片。在整tt單tt柃旋轉鑄嫌模具中聚合之 首，蓊染色巔料於液It單《I中之戆浮液，塗敷至糗具表面 上。雄然此方法係提供一種舞鏡片表面緘予顏色之簡易方 式，但其礞實需要薅该模具壓花成印刷，使其具有特定幾 何形狀及閱芘〇 本紙張尺度適用中國國家標準（CNS ) Α4规格（210Χ297公釐） (請先閲讀背面之注意事項再填寫本頁) *?τ 經濟部中央標準局員工消費合作社印製 A7 ---- B7 _ 五、發明説明（4 ) 巳嘗試将柒料掺入鏡片中》其方式是在柒科存在下，薅 用以產生銳片之鏡水性單體聚合。例如，美國專利4,252, 421係揭示在一獯水不濬性酞菁染科存在下•使一種觐水 性單Λ聚合〇染科勢必巳被推獲在巳完成、經水合之銳片 中，因其舆水不相容。很不幸地，當銳片觑充分水合至大 於約40重量％水時，染科會瀘出鏡片，此鏡片係衍生自最 最常使用之鏡水性單體，Τ基丙蝉酸羶乙躏（ΗΕΜΑ)之聚合 反應。這在使用較高水含量物質時，更是一項問题。 该’421專利亦揭示將該柒科使用一種可聚合之乙缚基邇 行官能基化，及接著在用以產生該銳片之單體之聚合反應 期間，鎿合该經官能基化之柒科。隼然此可免除對拎後-結合步驟之需求，但此鏡片之水含量會受不利影梅，除非 藓规水性-S03H或-S03Na基圈加至酞菁染料核中（如該專利 之第8棚中所討論者）》這只是在製造過糕中增加另一镅累 贅步騄，以使得隱形眼銳逋合長期配戴應用。 以一種類似方式，歐洲專利申請案〇 396 376掲示使用 一種未带《荷之SU染科，其係使用一種可聚合基圈遘行 嘗能基化，以在該親水性單體聚合作用期W，幫助该覦嘗 舱基化染料之麯合。很不幸地，此未蒂電荷之染料，會導 致降低水溶解度，就是有也很有取，其依次會睐制可存在 於鑪片中之柒料濃度。然而，更耋要的是，該官能基化之 BU染科，係爲此情況中必要之雙官能性染料。此甓官能 性，事實上會產生一種成爲交鞯劑之染科。麯果，該銳片 之水含量係進一步被降低，且當染料在銳片中之濃度增加 (請先閲讀背面之注意事項再填寫本頁) " 訂 -! 本紙張尺度適财關家料（CNS ) A4· ( 21GX297公ί ) A7 B7 五、發明説明（5) 時，使Λ此雙貧嫌性染科所製成之鍍片，具有蠱法令人接 受之易碎性。 最後，欲瓣隱形擊聽贓予巔氣之另一種嘗试•镉搞示於 美_專利4,639,105中。此專利镡揭示薅一種液癱單Λ、 可瘳性柒科及巔科粒子之Λ舍场旋轉鑄襄，以製馕一種具 有巔色蓋異之銳片，该廉色差異係在旋轉鑄雎期閜，藉由 麇料粒子之滌移而達成。維然此專利表示该染科不會潜移 ，隹1未指Α镉使用何種特定染科•且咸信此種染科事實 上在配戴期《必會聲移或瀘出，瞭彝所使用之染科使用如 上述之可聚合基國遶行嘗龈基化0再者•此種銳片不遑合 應用於其中必須成需要染科成著色#1均句分教之情況。 鑒於先曹技善之缺失，故需脣一種鑲濟方法，以製播一 種微柒隱形篆親，而無需薅巳完成之銳片漫溃在乘科露液 中之步驟。 臺„明瘟达 經濟部中央標準局貝工消费合作社印製 ---,--^----(秀-- (請先閲讀背面之注項再填寫本頁) 本♦明爲一種製儔聚舍用單Λ-染科化合物之經改良方 法》该化合物可接著舆用以製造软式水裊膠醣形眼銳之單 «—起聚合。其改良事項括在可有效製#高純度可聚合 單官龅性染科之條件下》薅《柒科舆該鏡水性單體反應。 然後，在用以製造該欷式水鞭滕|«形篆銳之單黴之均句瘳 液存在下，使該高純度單會親性染科聚合。本發明之改良 方法，不必在用以產生該巳完成銳片之貌水性單«聚合作 用後·薅羡片浸潰在染料水瘃液中。此外，不必在親片形 本紙張尺度適用中國國家椹準（CNS ) A4規格（210X297公釐） 83. 3.10,000 A7 B7 五、發明説明（6 ) 成後，使染科鐺合至鐘片。之所以如此，孫因該可聚合單 賞能性染科俥伴随著用以製造该軟式水鞭謬隱形篆鏡之龜 水性單《—起聚合•且因此係爲該鎪片聚合《主鰱之一偭 龙整部份。 於親片中淺t之蕷度•可覦精密地柱剩，依該可聚合單 言齙性染科於親水性單《溶液中之濃度而定。再者，該經 微染銳片之场躧舆光學性質，基本上#相當於未縿入Λ染 料之相應親片之物现舆光學性質。倒如，當使用本發明之 經改良方法，薅柒料糝入鏡片中岭，處瑗特性、配戴者舒 遑性及鎪片遣明性蘆未被犧牲。最f要的是以下事實•因 其主要爲單t詭性，故不會充作交欒劑，所以允許在銳片 中#入缯加量之染科，而不會犧牲水含量及處躧特性》例 如鏡片之捷齒性。 簪明#逋 關於舆該親水性單«反應之A基三·并柒科之較佳種類， 2-羶基T基两蝉酸禱备爲二A基三嵴染料，尤其是具有至 少一個磺酸根官鉋基之二氣三嵴染料，以使得該染科具有 水濬性。此種二氯三嘈染科係揭迷於例如美面專利4,559, 059舆4,891,046中，其镉各#入本文供麥考。最隹二氯三 •井染科爲染料素引反應性蓝色4號。具有至少一Λ磺酸礬 ITU!基之單氯三嘈染科，婀如反應性蓝色#2,亦可舆2-轰 基甲基两烯酸*反應而成爲銳片中之材科0除了染科索钔 反應性蓝色4號之外》可利用之水濬性染料保也括Procion 本紙張尺度適用中國國家標準（CNS ) A4规格（210X297公釐） .—^----Π裝— (請先聞讀背面之注f項再填寫本頁) 訂 經濟部中央梯準局負工消费合作社印«. 83. 3.10,000 Α7 Β7 經濟部中央揉準局貝工消費合作社印製 五、發明説明（7 ) 蓝色MRS;纖綠反應性明亮蓝色MRS; 2-M磺酸，1-膝基-4- (3-((4,6-二氣-蠓-三嗜-2-基）騰基）-4-磺苯赡基）-9,10-二氳-9,10-二氣基，二麯廬；2-®磺酸酸，1-赡基-4-(3-((4,6-二氯-1,3,5-三嘈-2-基）狭基）-4-)磺苯基）狭基）-9,10-二氳-9,10-二氧-二麵廬；及2-蕙磺酸，1-臃基-4-( 3-((4,6-二氯-蠓-三哜-2-基）狭基>-4-磺笨臁基）-9,10-二氳-9,10-二氣。 Μ於使该水溶性函基三嘈染科舆該親水镍單tt反應》以 製儺一種主要爲單貧覦性染料之條件•係依所遷走之特定 單Λ及所使用之_基三嗜染科之類S而定。此等條件可容 易地以經膽方式決走。 若此反應之麯果是解形成之可聚合染科化合輪中不值於 50%，僅具有一籲衍生自铖染科舆该親水性單黴之反應之 反應性官龅基位置，則该可聚合染料《爲高度單t饞性。 若大於50%之該可聚合染科化舍物爲雙官覿性，飇《染科 薅充作一種交礴劑，此交專劑可饞會不利地影鬌所定成銳 片之#瑾性質。較值情況是，不低於80%之被可聚合乘科 化合騐爲單官觝性。環想上是星少95%之該可聚合染科爲 翠官旒性。 染科舆單tt之反應可有利地發生於鹾存在下•该酸觎隽 促達單値舆染科瘳解。若薅等奠耳成奠耳過量之單Λ加入 反應《合物中，用此反應可更抉《動至完成》反應瓤度較 隹係提升至高於窒籯，例如35-70Χ：，歷覦约16至32小時 〇當反應完成時，洗舍物較隹穩被中和至pH植5-8之閼〇 (請先閲讀背面之注ί項再填寫本頁} '裝· 訂 Λ. 本紙張尺度適用中國國家標準（CNS ) Α4规格（210X297公釐） 83·3· 1〇,〇〇〇 經濟部中央梯準局属工消费合作社印製 297830 A7 B7 五、發明説明（8 ) 任付過量之反應粉、瘃铡及《產场，可使用罾Λ方法由反 應性染科化合物中移除° 路易士驗溶則《充作供單殖舆染科閹反應之情性#釋剩 。逋當瘳劑之實例，係也括嘥嚏、w氳呋鴆（THF)及二甲 亞M(D1S0) 〇輙是，較佳濬瘌係爲合水鎗，較隹爲鎗成》 土金屬破酸嫿或磷酸廬0 於本文中使用之軟性水裊鏐隱形眼Λ，#推一種铱裊謬 鐘片，其係衍生Λ一種含有親水性單嬗之翠«觚合场之聚 合反應。親水性單殖係指任何單Λ，當其覦聚合時，會產 生一種當輿水接觸峰靝典形成水裊謬之龜水性聚合黴》親 水性單《I之實剩，&栖，但不鼠於，两蜂酸成甲基两蜂酸 之羶基瞄、Ν,Ν-二甲基两蝉鑫HKDIIA)、Ν-乙燁基《9氳哒 咯酮（N1TP)及苯乙燁磺酸，及此項技藝中巳知之其他鏡水 性單髓。薅It後彤成之聚合tt銳片使用大量水使其膨赈， 而形成水藁鏐銳片*其典31上舍有大於30%，且較值爲至 少65%水。 較佳親水性單氬爲两譁酸成T基两蜂酸之擻基_。鼉蜂 酸舆甲基两蟑酸之臬基酯，其實婀也括•铽不f|L於甲基两 蟑酸羶乙_(H£MA)、搬基丙蝉酸乙醻（冊A)、T基两蟑酸 甘油曝、泉基T基两蜂酸两《、泉基两蜂酸两鷗裊羶基三 亞甲基两蜂酸醱〇两蝉酸成T基两譁酸之最隹臬基鷗爲 HEMA，其保爲最常用於软式水裊鏐ft形醎銳製備上之單饉 Ο 親水性單髓較值係於單黴反應洗合场中，舆共單黴共聚 -10 - 本紙張尺度逋用中國國家揉準（CNS > A4規格（210X297公釐） 83.3.10,000 (請先閲讀背面之注$項再填寫本頁) .裝. 訂 經濟部中央揉準局貝工消费合作社印製 Α7 Β7 五、發明説明（9 ) 合，以喊予化學舆軔《性質上之特定改良，依所欲之特定 應用而定。例如•苦T基丙烯酸〇fAA>係作爲共單毓使用 ，則鏡片之平衝水含量可增加。此外，多官能性交麟用單 Λ，例如二T基丙蝉酸乙二醇酶（EGDMA)舆三T基两蝉酸 三羶甲基两统釅（TMPTMA)，可於反應Λ合物中以相對較少 量，作爲共單黴使用，以改良鏡片之尺寸安定性及其他物 蠼性質。网樣地，可針對持殊應用而添加其他成份，倒如 舞親片竦予UV吸收性質。 單《I反應％合物亦&括起始Μ，暹常爲約〇.〇5至1 %之 一種以热活化之自由基起始劑。此獯起媸剩之典«實倒 括過氧化月杜蟾、過氧化苯T鱸、過璣酸異两基醱、供氬 雙異丁腈，及巳知氧化遘原系统》例如過破酸錶-儒至疏 酸氳納戴合及其類似物。亦可採用藉由紫化練、t子束成 致射源之脈射，以起麴聚合反應，视情沉縢加一種聚合起 妯劑•倒如安息香及其酼類。 單Λ反應逐合物之聚合作用，係在薅Λ合物舆所需要量 之可聚合染科接觸後進行•兹形成染科於Λ合物中之均句 瘃液。形成均勻溶液所需要之時《，可容易地以觎驗方式 決定。 級溱加至反應遇合物中之可聚合染料量，爲可舞銳片有 效碱予所要微染成著色觑度之量。此量可容易地以覦驗方 式決走，及依舰片肩圍厚度、反應性單馥泥合_之成份及 其他因素而定。 本♦明之覦改良方法，較佚#用以舞鍍片碱予可見性或 -11 - ——^----Η裝------訂------(泉 (请先Μ讀背面之注f項再填寫本頁) 本紙張尺度逋用中國國家標率（CNS ) A4规格（210X297公釐） 83. 3.10,000 經濟部中央揉準局WC工消费合作社印製 A7 B7__ 五、發明説明（10 ) 處璦性微染》此量係爲使得若暫時供籯時，淝戴者能麹在 處理期閜明鎮地注意到銳片，仅此量不應致使觎著&之鏡 片用國易於舆使用期KQK戴者之角軀臁別》於聚合作用之 翁，爲達成所要之可見性微染而添加至該均句浓液中之可 聚合染科量》係依所加入浓液中之染料纯度而定，园此其 應以覦驗方式決龙。一般而言•其應滿蓋約0.01至約0.35 %之範圃，以该親水性單Λ之重量爲基準，較佳爲約0.01 至约0.20重量％ »最佳範Ν爲约0.05至约0.15% » 或者，本發明之覦改良方法，可提供澍鍍片碱予加肇教 染之萍性。加蕷微染只是加蕷鼠戴者原本篆峰巔色而巳， 以致例如蓝色篆睛，由於銳片上之加蕷微染，故蓊續示更 具"蓝色"。覦加入該均勻瘃液中以加蕷微染之可聚合染科 之量，其期重範《爲約0.35至约0.75%，以龜水性單«之 重量爲基準•較佳爲約0.35至约0.50%。此聚合反應可於 惰性稀釋存在成不存在下進行。若該聚合反應係於#釋 劁不存在下遶行*則所形成之聚合ΛΛ合物可被褽成所要 之銳片形狀》例如箱車床切«，然羲於此項操作後，使Λ 必要*之水遶行膨脹。成者，且更佳的是，此聚合反應孫 於一種遒當惰性稀释劑存在下達行。較佳惰性稀釋劑爲一 種水-可蠹换之硼酸繭〇所要獼酸麵之特性，以及醣在聚 合反應遽合物中之較佳濃度•镉样迷於美國專利4,680,336 中•其#併於本文供麥考。當使用稀釋制時》用以形成所 脣鎪片之較佳方法，係&括離心鑄膿舆鑄造成塑，例如使 用美國專利4,565,348中所迷之糲具，以及此等方法舆一 本紙張尺度遥用中國國家梂率（CNS ) Α4規格（210Χ297公釐） 83. 3.10,000 (請先閲讀背面之注意事項再填寫本頁) 裝. 訂 經濟部中央揲準局貞工消费合作社印製 A7 B7 五、發明説明（11 ) 舨性地於本文中所猶迷之其他方法之戴合。 當製備此Λ片之聚合反應巳足麹完成時》可蓊此Λ片水 合至其平衡水含量》此銳片之水含量癔爲约35至约80重 量％，更佳爲约55至約65重量％。威Λ此範可蠼想地使 用在其中癀人舒遑性及處躧性之特徵爲重要性質之長期配 戴應用上。 下迷實例係意欲説明所請求之本發明，且董非教想以任 付方式陳制其範_。在所請求之本發明之範國舆精神内之 許多其他具Λ實施婀，對於熟請此藝者而言，薅會變得類 而易見。 於隱形•銳製儎實例中所使用之成份，镖缩寫如下：2-臬基Τ基两蟑酸乙醱（ΗΕΜΑ>、Τ基两蜂酸（ΜΜ)、二甲基 丙缚酸乙二醇躏（EGDMA)、甘油之硼酸·（每莫耳甘油0.16 奠耳钃）（GBAE)、乙氧碁化甲基鐮苷二月核^_(MLE-80> ，反應性篮色#4[2-菖磺酸，1-腌基-4-(3-(4,6-二氣-蠓-三•丼-2-基）臃基）-4-磺苯臃基）-9,10-二氳·9,10-二氧】( RB4)，其係爲一種二氯三噃染科及ar-觀基-a , at-二甲基 苯乙_(Darocur 1173)，其係爲一種UV反應性起姑劑〇於 所有實例中所使用之HEMA，#爲具有低於0.1重量％離質 之高度炖化HEMA。 ΛΚΑ測定實铡之表1中所列示之物瑾舆光學性質之試驗 方法，如下： ΜΛΜΜ 觚過钂片之氧逶氣性镉以Dk值乘以10-n表示》其單位 -13 - 本紙張尺度適用中國國家揲準（CNS > A4規格（210X297公釐） 83. 3. !〇,〇〇〇 ----·----「裝-- (請先聞讀背面之注$項再填寫本頁) 訂 ，泉 A7 B7 經濟部中央標準局員工消費合作杜印製 五、發明説明（12) 爲公分•毫升〇2/秒•毫升•毫米恥。其係使用軛譜儀氡感 测壽度量》其包括4毫米皇裎金除軛及鑤-氯化錄環釅極〇 枝眢（嫌釐、#1拿龙騸磨、 將欲被測试之鏡片切割成所要試樣尺寸舆形狀，益度量 橫截面面積。然後，薅試樣困定在一種裝有測力計之恆定 速率十字頭移動琅測试機之上方夾具中。使十字颂下降至 最初曝距長度，益将弒樣接至囿定夹具》然後薅試樣於愾 走速率之應變下伸長，益記緣所造成之應力-應變#練。 伸長率係以百分比表示，而抗張輾教舆蕷度用以psi(睾平 方英吋之磅教）表示。 P邊先皐 此方法可應用於光遣躲覦過銳片之測走。使一束先練（ 200- 800毫微米）通過一镅在濬液中含有銳片之石英盒。 度量光離《金之肇度，並對入射（麥考物）光束作成比例。 其數值係以％透光率表示。 撤Jfe安定惊 薅銳片在熱麈鎬中毅蓠30分鐘，益走性地舆未經熱蜃鎢 處理之鐘片比較微染強度之頷失。薅此耝序重複5次，未 損失微染蕷度之錢片，算是通過此項試螓。 宭制1 獻結合UEMA之iLA性:合A 1 於500毫升圓底燒瓶中，放置350毫升5%K2C03濬液。於 其中添加0.10(13.0克）奠耳HEMA，兹薅泥合物楂拌10分鎊 。於上迷溶液中添加0.08(51.0克）奠耳RB4。於柒料完全 -14 - ................裝................訂..........線 • f ( (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準(CNS)A4規格(210X297公釐） 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（13) 分教後，使瀵度提升至40-50*€之閾。使用Hanggi等人， 分析生物化學IM, 91-104(1985)中所迷之層析HPLC方法 ，追蹤此反應，以蠃技氯基三·弁柒科舆單言龅性醉類之反 應。使用此方法，於大约42分鑲時見及覦單取代之單氯基 三"丼-HEMA可聚合染料之形成0 於40- 50小時後，當足夠轉化半巳達成時，可将反應邋 合物過瀘，及收集瀘菁1乾煉。此瀘軿”本身"即可用以微 染醣形暾銳0可将濾液使用旋轉式蒸發黑遶行眞空汽提， 以自反應產物中移除水0可将殘留之蓝色粉末用以微柒鐃 片。可依微柒之要求條件’移除無機化合物。A基三p井之 轉化率，可藉由降低反應Λ合物中之水量而増加。此亦會 增加該染料之甓官覦性衍生物之量。 耆裥2 鑣艫舂香服篇▲之反廬性»抖RB4 :合成·2 所迷之反應可以下迷方式進行，而得大約85%地單官龅 性單氯基三噃-ΗΕΜΑ可聚合染料。於裝有钱械攪拌装麗之 兩升三領夹套洗瓶（於添加試劑之前，冷卻蘑瀵度應巳設 定至22°C)中，放置497.2克（27.62莫耳）水及9.95克（ 0.0721 奠耳)K2CO3UCS級，Aldrich # 20,261-9)«» 在雎 加其他試劑之前，使此溶液逮成平衡至22<>c。反應溫度應 加以璽控，同時添加拭劑。上迷濬液之PH值係保持於10一 12 〇於此溶液中添加497.2克（3.82奠斗）高度纯化之HEMA( 0.1263%) EGDMA與0.0275% MAA，作爲鞲質，Rhoi Tech Mhoroier BM-920 ;應使此Λ合物達成平衡至22*C。添加 -15 - ................裝................訂----------：---:(線 (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準(CNS)A4規格(210X297公笼) 297830 A7 B7 五、發明説明（14 ) 經濟部中央標準局員工消費合作社印製 全部76.5克（0.120奠耳）RB#4，使此濬液泥合三十分鐘， 或直到所有團逮均巳消教爲止。薅反應澴度提升至4〇χ：, 並藉HPLC璽控肋#4吸收蜂之消失。當RB#4吸收绎低於全部 發色團蜂面積之3%時（大约170小時），薅反應洗合物使用 肊1(40:1)之肴溶液中和，直崗？8植约6.5至7.0爲止〇攪 拌30分鐘及過瀘。葑濾麯從布氏漏斗轉移至眞空保乾蘑， 並使其乾燥。研缽舆杵棒瀘《可视情況使用Et20、EtOH、 丙期或CH30H洗滁，以移除任何有機麯質，倒如，防DMA、 ΜΔ▲或乙二醇。 3 經麯合至HEMA之反廬掩A斜RB4 :备A. 3 於一升洗瓶中添加76.5克反應性蓝色#4,及450克去離 子水。将内容场於室蘧下现合30分鑲。於旎瓶中溱加497.5 先羶基T基两蟑酸乙釅（HEMA)。葑内容物现合20分钂。然 後，漆加12.7充礦酸_於去離子水中之濬液。薅内容物加 熱至40eC，歷簸96小時。蓊遇合物使用2.5N硫酸中和至 pH值6.5。將此洗瓶之内容物冷_至5X：，蜃覦24小時。薅 產物藉眞空過濾田收。薅_溪之國體嫌浮於1〇〇克由50克 去離子水舆拭劑（乙基）醇所舨成之溶液中。酹產物藉眞空 過瀘田收。薅此洗鲦之產物鼴浮於1〇〇克試劑（乙基）釀中 ，益藉眞空過瀘收集。薅此產物於宣霣及〈1毫米Hg之眞空 下乾燥。 此合成之產物，產生19.9充蓝色粉末，當藉HPLC分析時 *其獲得單獨吸收哞。 16 - 本紙張尺度適用中國國家標準(CNS)A4規格(210X 297公楚·) 請 先 閲 讀 背 意 事 項 再一 填 寫 裝 訂 線 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（is) 耆#1 4 觎麯合至ΗΕΜΑΙΑ龜栓麝拆RB4 :厶出4 於一升洗瓶中添加75克反應性蓝色#4,及572.5克去離 子水β將内容物於室濃下Λ合30分钂。於繞瓶中渗加187.5 先羶基f基丙蟫酸乙釅（ΗΕΜΑ) 〇薅内容物泥合20分鐘。於 此溶液中添加11克50%氳氧化鏑緣液。蓊内容軔於室瀛下 攪拌一小時。將Λ合物使用2.5N破酸中和至pH彼6.5。薅 此燒瓶之内容物冷钟至5X：，廉覦24小時薅產物藉眞空 過濾田收。薅濑漢之困«浮於100充由50克去離子水舆 試劑（乙基）醇所级成之溶液中。薅產物藉眞空過瀘田收。 将此洗鲦之產粉龜浮於100克試劁（乙基）醇中，益藉眞金 過濾收集。薅此產物於宣蒎及1毫米Hg之眞空下乾燥。 此合成之產物，產生17.2克蓝色粉末，當藉HPLC分析時 ，其獲得單獨吸收峰。 f #1 5 A結合至HEMA之反廬栓鏖抖RB4 :合A 5 於100毫升洗瓶中，添加9.0克反應性黑色#5(Re*azol；t 色B，cas 17095-24-8)及57.2克去離子水，將内容物於t 温下Λ合30分鐘。於旄瓶中添加18.7克獲基T基丙蟑酸酶 。薅内容物洗合20分鐘。於澉液中添加1.04充50%氳氡化 餉溶液。将内容物於室瀵下攪拌1小時又20分鎊。將Λ合 物使用2.5Ν破酸中和至小的pH值6.0〇薅洗瓶之内容物冷 卻至5°C，廉經24小時。錡產场藉眞空過濾田收》薅此產 物於宣Λ及低於1毫米Hg之眞空下乾燥。此合成之產物， -17 - 本紙張尺度適用中國國家標準(CNS)A4規格(210X 297公釐） ..............裝................tr................線 • . ( { c請先閲讀背面之注意事項再填寫本頁) 五、發明説明（16 ) A7 B7 經濟部中央標準局員工消費合作社印製 產生0.52克籃色粉末，當藉HPLC分析時，其獲得單獨吸收 峰。 A有惠水士♦之經教裊酿裉BL鐘乏遒積 將下迷成份泥合，以形成均句糝合物：58.08份HEMA、 0.71份EGDMA、0.恥份MAA、0.14份Darocur 1173、0.07扮 於實例3中合成之可聚合染科、及40份GBAE。當被包含在 隱形取鍍糗具中時，藉由爆露至UV光下，使上迷縿合物聚 合0於聚合作用完成後•打闥模具，薅巳摸製之鐘片浸沒 於0.50%MLE-80之水濬液中，或其中巳添加0.50%iLE-80 之0.90%NaCl溶液中。於溶液温度在60- 70X：之«，踌輾 製軔廬於上連濬液中。此皺微染鐘片之场瓊舆光學性質係 示於表1中，作爲實例1。 爲比較目的起見，一《未經微染之鏡片，及一種使用罾 用方法覦微染之Λ片，其躲瓚舆光學性質#示於表1中， 個別作爲對照實例▲舆Β〇該未缓微柒之銳片，係以實質上 相同於上述之方法製成，惟未使用染科。使用罾用方法所 微柒之親片，係以下述方式製備，首先薅該未覦微染之銳 片浸泡在一種含有〇.5〇%MLE-80之RB4瘳液中，然後在最 後水合之前，藉由舆合水鎗接觸，使RB4鯖合至该經浸绝 之銳片。 (請先閲讀背面之注意事項再填寫本頁) 裝. 訂. 線 -18 - 本紙張尺度適财S 0家料(CNS)A4絲(21GX 297公釐) A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（17 ) 表1 級微染隱形睬鏡之物蠼舆光學性質 A 瑾栓訾 耆钿 水含量％ 60 60 60 氣遭氣性 28 26 28 抗張模數，psi 36 36 34 伸長率，％ 120 118 128 抗張蕷度，psi 32 35 34 办 «性 瞀 逶光率 最小彼％ 85 85 85 微染安定性 是 —· 是 於表1中所示之錄果，係説明株據本發明之覦改良方法 所製成觚微柒隱形隊鏡之#理舆光學性質*係實質上舆相 應未經微染之隱形睬舰及藉罾用方法所微染之隱形眼銳之 性質相同》 19 - ...............-I.......裝—...............訂.......！：：線 .· ( ( (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準(CNS)A4規格(210X 297公釐)Printed 297830 at Β7 by the Employee Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs V. Description of Invention (1) The invention case is a part of the US Patent Application with a narrow order of 966,232 filed on October 26, 1992 In a series of consecutive cases, the entire contents are incorporated into this article for McCaw. The present invention is a method for giving Gu color by dancing invisible birds. More clearly, it relates to an improved method for making highly pure compounds of naan hydrophilic monococcine and dye. The method of using the light-colored method of evenly dividing the humble test in the "Shadow Stealth" is described in, for example, US Patent 4,468,229. Generally speaking, the first step is to immerse the sharp piece in the aqueous solution of the dyeing department, and then in the americium solution to make the cobalt cobalt to the lens. The paddles are typically made of a hydrophilic polymer derived from the polymerization reaction of water-based monomers. Dyeing is the last step of the lens hydration, which is the last step of the hydration step. By contacting the sharp piece of the core with a water-containing sac, it is intended to provide softness with the desired amount of water at an acceptable pH. Soft hydrogel sharp tablets. The dyes used in the method of application are typically derived from a base-based philosopher, such as a diuretic base or a single base-based triple well, especially water-soluble two-gases. For example, the pedicle has two functional groups of sulfonic acid brigade. And or ## based triphilic dyes can be drowned in water. Therefore, the mackerel must be hydrated at the end of the hydration step, and the hydrophilic polymerization Λ used to form the lens together. Otherwise, the material will move in the lens, causing uneven dispersion, or filtering out sharp pieces to escape into the wearer's sakizaki. After the mackerel is formed, it is made by using the method Soft sharp tablets are light-colored dyes, which are not only dispersed in sharp tablets, but also do not apply the Chinese National Standard (cns) Α4 specifications (210X297 public envy) on the sharp paper scale (please read the precautions on the back before filling in (This page)-*? Τ City — A7 B7 printed by the Staff Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy V. Description of the invention (2) The sound in the film is transformed into a piece of ship. This grade of slightly stained Λ film is also very stable in aqueous media and after repeated high-intensity cycles. This method of application requires that the progenitor tablets be dipped in a concentrated solution containing the dyeing department, which is at a specific concentration and under a specific conductivity, so that the dyeing department will be dispersed to the Jushe. . The conductivity is very important, because the concentration of Xian tablets can be suppressed by choosing the concentration of salt. It is also important that the concentration of the material and the sharp piece stay in the material immersion liquid W, should be accurately checked, because the expansion of the dynamics of the education will determine the degree of the micro-stained contact lens. This method of application is to use high concentration dyes in Qike lotion, so that continuous micro-dyeing operations can be performed. Unfortunately, this method is very cumbersome and requires multiple steps, especially in commercial-scale manufacturing, because it must be immersed in Zheke dredging fluid at a specific concentration and time. Dyeing is dispersed in sharp films. Therefore, because of this difficulty, we are looking for alternatives to insult. U.S. Patent No. 4,559,059 indicates that a polymerization gun may be approved, a single «, such as 2-methyl ethyl pyrocrylic acid, a reactive dye reaction, and then used to produce a single hip to be kissed During the polymerization reaction, the single unit is dyed. Nong Yeh, this patent does not describe the method and the reaction conditions necessary for the preparation of the polymerizable monomer-Qike unit. Among them, "Quality" covers from high-concentration Qin Jilu to surfactants used as anti-dust agents. The material dart is a processing aid, such as inorganic win, to accelerate the dissolution of the material. Adding the addictive ingredient is the main application of Dyeing Department. It is aimed at the micro-dyeing of locust textiles. Such additives will make the reactive dye more functional on the fabric. For the synthesis of gadolinium-containing dye precursors and reactions, the paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297mm) JL, 4 ------ order ------ cheng 丨 (please first Read the precautions on the back and fill in the text) A7 _B7_ printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 5. Invention description (3) Product. These substances are inactive and must be removed from production water before they can be discharged into an urban sewer system. According to public opinion of the Department of Dyestuffs, the common fruit of water-based monoploidy reaction is a single official gingival single-medullary unit with low yield. Therefore, one of the items of the present invention is to provide a highly purified single Λ-dye unit. It is also an item of the present invention to provide a method for preparing highly purified monomyeloid-dye units. A shortcoming about the use of the classical plastic reaction to couple a dye to a hydrophilic monomer unit comes from the fact that Dian Lang used to make the invisible mirror look good. U.S. Patent No. 4,157,892 discloses the addition of a functional group to the polymeric hip used to produce sharp tablets. This functional group is reactive toward the couple. This kind of polymerization of turtle functionalization is made by the reaction of "a pseudo-synthetic agent single hip" and a kind of arm with a mirror-based single-arm reaction. This single agent has a high possibility of changing the physical properties of the polymer It is made from the sharp piece of the guanyi-based polymerization Λ, which is dipped in a solution of heavy argon dye, so the dye is recorded in the polymerization «. Falcon happens to be confused with the mackerel. For this method, it is still necessary to diffuse the finished lens in the material solution. Another method for giving soft color to the pro-film is disclosed in US Patent 4,640,805. This patent describes the use of treasure rotation The film technology uses a class of micro-stained lenses. It is the first polymerized in a rotating casting mold, and the dyeing material is applied to the floating surface of the liquid It single sheet "I" and applied to the surface of the pad. This method provides a simple way to add color to the surface of the dance lens, but it really requires the mold to be embossed into printing to make it have a specific geometric shape and reading. The paper size is applicable to the Chinese National Standard (CNS ) Α4 specification (210Χ297mm) (please Read the precautions on the back and fill in this page) *? Τ A7 ---- B7 _ printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economy _ V. Description of invention (4) Trying to incorporate materials into the lens》 The way is In the presence of Zygophyllaceae, the water-based monomers used to produce sharp films are polymerized. For example, U.S. Patent 4,252,421 discloses that in the presence of a phthalocyanine dyestuff in the presence of water, a single water-based polymer can be polymerized. Dyeing is bound to be pushed into the finished, hydrated sharp tablets, because their water is not compatible. Unfortunately, when the sharp tablets are fully hydrated to more than about 40% by weight of water, Dyeing will be released Lenses, this lens is derived from the most commonly used mirror water-based monomer, the polymerization reaction of T-propyl propionate ethyl acetate (HEMA). This is even more of a problem when using higher water content substances. The 421 patent also discloses the functionalization of the family with a polymerizable ethylidene group, and then during the polymerization reaction of the monomer used to produce the sharp piece, the functionalized family with the family. Falcon can eliminate the need for the back-combination step, but the water of this lens The amount will be adversely affected, unless the Moss-based water-S03H or -S03Na base ring is added to the phthalocyanine dye core (as discussed in the 8th shed of the patent). This is just adding another americium in the cake Cumbersome steps to make the invisible eyes sharp for long-term wear and application. In a similar way, European Patent Application 396396 shows the use of a non-Netherlandish SU dyeing department, which uses a polymerizable base ring. It can be basified to help the hydration of the tank-based dye during the polymerization period of the hydrophilic monomer W. Unfortunately, this uncharged dye will result in reduced water solubility. It is beneficial that it will in turn favor the concentration of the surplus materials that can be present in the furnace sheet. However, more importantly, the functionalized BU dyeing department is a bifunctional dye necessary for this situation. The functionality of this 甓 will in fact produce a dye family that becomes a cross agent. For koji fruit, the water content of the sharp tablet is further reduced, and when the concentration of the dye in the sharp tablet is increased (please read the precautions on the back before filling out this page) " Order-! This paper size is suitable for financial materials (CNS) A4 · (21GX297 公 ί) A7 B7 Fifth, the invention description (5), making the plate made by this double-poor and susceptible dyeing department has the fragility that the Gu method is acceptable. Finally, another attempt to invisibly listen to the stolen goods in order to flap the petals • Cadmium is shown in US_Patent 4,639,105. This patented rumbling reveals that a liquid palsy single Λ, lameable keelaceae and peduncle particle Λ yard rotation casting cast, in order to make a naan with sharp color difference sharp film, the cheap color difference is in rotating casting The period is achieved by purging the particles. Weiran's patent indicates that the dyeing department will not sneak, and the 隹 1 does not refer to what specific dyeing department is used for cadmium. And Xianxin ’s dyeing department in fact will "sound or move out, Yi The dyeing department used uses the polymerizable base as described above to bypass the gingival base 0. This kind of sharp film is not suitable for cases where the dyeing department must be colored # 1 even sentence division teaching. In view of the lack of Xian Cao Jishan, a method of embedding is needed to produce a kind of invisible seal kisser, without the need for the step of the sharp film that is completed in Cheng Ke Lu. Printed by Taiwan Beiming Consumer Cooperative of the Central Standardization Bureau of the Ministry of Economic Affairs of Mingwenda ---,-^ ---- (Show-(please read the notes on the back before filling in this page) This is clearly a system Modified method for single Λ-dye compound used in the polymerization process. The compound can then be polymerized for making soft hydrogels sugar-shaped eye-catching sheet. The improvement matters are included in the effective production of #High purity Under the condition of polymerizable single-offensive dyeing department "," Yi Keyu reacts with the mirror water-based monomers. Then, there is a homosexual solution that is used to make the water-based whip Next, the high-purity single-unit affinity dyeing department is polymerized. The improved method of the present invention does not need to be immersed in the dye water solution after the water-based single «polymerization used to produce the appearance of the sharp tablet is completed In addition, it is not necessary to apply the Chinese National Standard (CNS) A4 specification (210X297 mm) at the size of the pro-sheet paper. 83. 3.10,000 A7 B7 V. Description of the invention (6) After the completion of the invention, the dyeing machine shall be closed to the clock The reason for this is that Sun because of the polymerizable single-energy dysplasia is accompanied by the turtle water used to make the soft water whisper invisible seal mirror "Single"-from the polymerization • and therefore the entire part of the main part of the silver carp, "Long Long." In the pro-film, the shallowness of the t can be expected. The sex dye department is determined by the concentration of the hydrophilic sheet "solution. In addition, the optical properties of the micro-stained sharp film are basically #equivalent to the corresponding parent film of the dye that has not been inserted into the Λ dye. Nature. It seems that when using the improved method of the present invention, the raw material will enter the middle of the lens, and the characteristics, the wearer's comfort and the weariness of the reed are not sacrificed. The most important thing is the following Facts: Because it is mainly single-trick, it will not be used as a crosslinking agent, so it is allowed to enter the amount of dye in the sharp film without sacrificing water content and treatment characteristics. Toothiness. 簪 明 # 逋 About the preferred species of the hydrophilic group «Reaction A group III · Pycnocaceae, 2-acyl group T group bisacid acid is a bis A group triridge dye, especially with At least one sulfonate official planer base two gas three crest dye, so that the dyeing department has a water dredging property. This kind of dichlorinous tridysene department is fascinated by, for example, beauty noodles In Lee 4,559, 059 and 4,891,046, their cadmium # is included in this article for McCormick. The most dichlorotrichloride is well dyed by Dyein Reactive Blue 4. It has at least one sulfonate ITU! Chlorine III Nosocomial, such as reactive blue # 2, can also react with 2-bombyl methadienoic acid * to become a material in the sharp film. 0 Except for dyeing blue, reactive blue "External" available water-dyeing dyes also include Procion. The paper size is in accordance with Chinese National Standard (CNS) A4 specification (210X297mm). — ^ ---- Π 装 — (Please read note f on the back first (Fill in this page again) Ordered by the Ministry of Economic Affairs Central Bureau of Standards and Traders' Consumer Cooperative Print «. 83. 3.10,000 Α7 Β7 Printed by the Ministry of Economic Affairs Central Bureau of Standardization Bureau of Peasant Consumer Cooperatives Fifth, Invention Instructions (7) Blue MRS; Fiber Green reactive bright blue MRS; 2-M sulfonic acid, 1-benzyl-4- (3-((4,6-digas- midge-triphilo-2-yl) tenyl) -4-sulfobenzene赡 基) -9,10-Di 氲 -9,10-dioxy, Diqulu; 2-® sulfonic acid, 1- quat-4- (3-((4,6-dichloro-1 , 3,5-Trino-2-yl) Narrowyl) -4-) sulfophenyl) Narrowyl) -9,10-Di-H-9-9,10-Dioxo-Dianlu; and 2-Huisulfon Acid, 1-yl-4- (3- ((4,6-dichloro-dichloro-trimethylene-2-yl) narrow base> -4-sulfonyl) -9,10-dioki-9,10-digas. Μ To make the water-soluble functional group noisy, and the hydrophilic nickel single tt reaction "to prepare a condition for the exclusion of a mainly single poor dyestuff Depends on S and the like. These conditions can be easily determined by courage. If the koji fruit of this reaction is not worth 50% of the polymerizable dyeing chemical compound wheel formed by the solution, and only has a reactive official niche group position derived from the reaction of the hydrophilic monomycetes from the dyeing department, then the The polymerizable dye is highly monotonic. If more than 50% of the polymerizable dyeing chemical compound is dual-functional, the "Dyeing Bloom" acts as a delivery agent. This delivery agent can adversely affect the #jin property of the sharp film set by Rui . The comparison is that no less than 80% of the polymerizable products are combined into a single official. On the ring, 95% of the polymerizable dyeing department is Cuiguan. The reaction of the dye department Yudan tt can advantageously take place in the presence of the falcon. The acidic scorpion promotes the solution of the Shandan Yudan department. If you dig into the excess of the single Λ added to the reaction "composition, use this reaction to select" Move to completion ". The reaction temperature is higher than that of the clam system, such as 35-70Χ: About 16 to 32 hours. When the reaction is completed, the washings are more stable and neutralized to a pH of 5-8 (please read the note on the back and then fill out this page) 'Install · Order Λ. This The paper scale is applicable to the Chinese National Standard (CNS) Α4 specification (210X297 mm) 83.3.10.1000. Printed 297830 A7 B7 by the Industrial and Consumer Cooperatives of the Central Escalation Bureau of the Ministry of Economic Affairs. 5. Description of Invention (8) Excessive amount of reaction powder, sham and "production site, can be removed from reactive dyestuff compounds using the Λ method ° Louise's test solution" is used as a sentimental #release left for single colonial and dyestuff reaction. Examples of bleaching agents also include bleed, wfurfur (THF), and dimethyl sub-M (D1S0). The preferred dredging agent is a hydration gun, which is better than a scorpion. "Earth metal Broken acid or phosphoric acid. 0 The soft water eyelid invisible eye Λ used in this article, # pushes an iridium eye bell, which is derived from a jadeite containing hydrophilic single transmutation « The polymerization reaction of the goblet field. Hydrophilic monoculture refers to any single Λ. When it is polymerized, it will produce a kind of water turtle when the water contacts the peak. , &Amp; inhabit, but not at all, two carboxylic acids into methyl two carboxylic acid bismuth base sight, Ν, Ν-dimethyl two cicada Xin (HKDIIA), Ν- 乙 烨 基 《9 氲 pyrrolidone (N1TP ) And phenylethyl sulfonic acid, and other mirror-based single-medullary known in this art. After the polymerization, the polymerized tt sharp tablets use a large amount of water to make them swell, and form the water ligustrum sharp tablets *. The upper part of the code 31 is greater than 30%, and the comparative value is at least 65% water. The preferred hydrophilic mono-argon is a benzyl group of two berylic acids to T-based two berylic acids. Phenyl berylic acid and the methyl ester of methyl two cockroic acid are actually included. Terbium is not f | L in methyl two cockroic acid 憻 乙 _ (H £ MA), ethyl propyl ethyl hexanoate (Book A) , T base two cockroic acid glycerin exposure, spring base T base two beesate two ", spring base two beesate two gull oxalic acid trimethylene two bee acid sulfonate two citric acid into the T-base two benzyl acid of the most clam The base gull is HEMA, and it is the most commonly used single vinegar for the preparation of ft-shaped compound sharps. The hydrophilic single pulp comparison is in the single mold reaction washing field. The size of this paper is based on China National Standard (CNS & A4 specifications (210X297mm) 83.3.10,000 (please read the note item on the back and then fill in this page). Printed by cooperatives Α7 Β7 V. Description of invention (9) In accordance with the specific improvement in the properties of the chemical industry, depending on the specific application you want. For example, bitter T-based acrylic 〇fAA > When used, the flushing water content of the lens can be increased. In addition, the multifunctional cross-linking single Λ, such as di-t-propylpropionate glycolase (EGDMA) and tri-t-dipicolinate triamylmethyl two-component system (TMPTMA), can be used as a co-monad in a relatively small amount in the reaction compound to improve the size stability and other properties of the lens. The mesh sample can be added for special applications. It is like a dance pro piece with UV absorption properties. The single "I reaction% compound also includes the starting M, Siam is usually about 0.05 to 1% of a free radical initiator activated by heat. This The classics of the leftovers «In fact, including Dudu peroxide, benzyl peroxide, isobiyl peroxyacid, bis-isobutyronitrile for argon, and known oxidative oxidation system" such as peracid table -Ruzhi Shu acid Kuna Daihe and its analogues. It is also possible to use the pulse of the source of the source by Zihualian and the T beam to start the polymerization reaction, and add a polymerization initiator as the case may be. • It is like benzoin and its hydrazone. The polymerization of single Λ reaction compound by compound is carried out after the contact of the polymerizable dyeing department with the required amount of 薅 Λ compound and the formation of the average sentence in the Λ compound Liquid. The time required to form a homogeneous solution can be easily determined by the test method. Polymerizable dyes added to the reaction mixture The amount is the amount of effective alkali for Wurui tablets to be slightly dyed to the coloring degree. This amount can be easily determined by the test method, and depends on the thickness of the shoulder circumference of the ship, the composition of the reactive single compound and the It depends on other factors. The improvement method of this item is better than that of ## for the visibility of the plated alkali or -11----- ^ ---- Η 装 ------ 定 ------ (Quan (please read the note f on the back and then fill in this page) This paper uses the Chinese national standard (CNS) A4 specification (210X297 mm) 83. 3.10,000 WC industrial consumption of the Central Bureau of Economic Development of the Ministry of Economic Affairs Printed by the cooperative A7 B7__ V. Description of the invention (10) Slight staining at the place "This amount is to make the wearer notice the sharp film in the town of Mingming during the processing period, but this amount is not It is necessary to make the use of lenses for & lenses easy to use during the period of use. KQK wearer ’s horns and body parting ”in the polymerization of Weng, to achieve the desired visibility of micro-dyeing added to the homojunction concentrate polymerizable dyeing "Technology" is based on the purity of the dye added to the concentrate, so it should be determined by the test method. Generally speaking, it should be covered with a range of about 0.01 to about 0.35%, based on the weight of the hydrophilic single Λ, preferably about 0.01 to about 0.20% by weight »The best range N is about 0.05 to about 0.15 % »Alternatively, the improved method of the present invention can provide the alkaline properties of the plated alkali to add to the education. Adding dyes to the vines is just the original color of the peaks of the wearers of the gargoyles, so that, for example, blue slender eyes, due to the dyeings on the sharp film, the continuation is more "blue". Add the amount of polymerizable dyestuff added to the uniform solution to the micro-dye, the expected weight range is "about 0.35 to about 0.75%, based on the weight of the turtle water-based unit", preferably about 0.35 to about 0.50 %. This polymerization reaction can be carried out in the presence or absence of inert dilution. If the polymerization reaction is detoured in the absence of # 释 劁 *, the formed polymeric ΛΛ compound can be ripped into the desired sharp piece shape, such as a box lathe cut «, but after this operation, Λ is necessary * The water swells around. The successor, and better still, the polymerization reaction was released in the presence of an inert diluent. The preferred inert diluent is a water-cocoon-replaceable boric acid cocoon. The characteristics of the desired kilic acid noodles and the preferred concentration of sugar in the polymerization reaction compound. Cadmium-like compounds are in US Patent 4,680,336. This article is for McCaw. "When using dilution system" is the preferred method for forming the lip rims, including & centrifugal casting and casting into plastics, such as using the rice dumplings described in U.S. Patent 4,565,348, and these methods and a piece of paper Standard remote use China National Frame Rate (CNS) Α4 specification (210Χ297mm) 83. 3.10,000 (please read the precautions on the back before filling out this page). Printed by the Central Economic and Trade Bureau of the Ministry of Economic Affairs. A7 B7 Fifth, the description of the invention (11) is a combination of other methods that I still love in this article. When the polymerization reaction to prepare this Λ piece is completed, "the Λ piece can be hydrated to its equilibrium water content". The water content of this sharp piece is about 35 to about 80% by weight, more preferably about 55 to about 65 weight%. This model can be used imaginatively in long-term wearing applications where the characteristics of human comfort and disposition are important properties. The following example is intended to illustrate the claimed invention, and Dong Feijiao wants to lay down his example by any means. In the spirit of Fan Guoyu of the claimed invention, there are many other implementation examples, which will become familiar to the artist who is familiar with this art. The components used in the invisible and sharp system examples are abbreviated as follows: 2-Homoyl T-yl Cockroic Acid Ethanol (HEMMA>, T-yl Two Beelic Acid (ΜΜ), Dimethyl Propionic Acid Ethylene Dioxide Alcohol (EGDMA), boric acid of glycerol · (0.16 mol of glycerol per mole) (GBAE), ethoxydimethymethyl fumarin binuclear ^ _ (MLE-80>, reactive basket color # 4 [ 2-pansulonic acid, 1-acryl-4- (3- (4,6-digas- midge-tris-pyridin-2-yl) yl) -4-sulfobenzyl) -9,10- Dihe · 9,10-dioxe】 (RB4), which is a kind of dichlorotripyridinaceae and ar-guanyl-a, at-dimethylbenzene ethyl _ (Darocur 1173), which is a kind of UV Reactive starter. HEMA used in all the examples, # is highly stewed HEMA with an off-weight of less than 0.1% by weight. ΛΚΑ Test for determining the optical properties of the substances listed in Table 1 The method is as follows: Oxygenous gaseous cadmium of ΜΛΜΜ gossip tablets is expressed by Dk value multiplied by 10-n》 The unit -13-This paper scale is applicable to the Chinese National Standard (CNS > A4 specification (210X297mm) 83 . 3.! 〇, 〇〇〇 ---- · ---- "installed-- (please read the $ item on the back and then fill in this page) , Quan A7 B7 The Ministry of Economic Affairs Central Standards Bureau employee consumption cooperation du printed five, the description of the invention (12) is cm • ml 〇2 / second • ml • mm shame. It uses a yoke spectrometer radon to sense the life measurement, which includes 4mm impulse gold decoupling and 鈤 -chlorinated ring ring electrode (Bailey, # 1 take the dragon to grind, cut the lens to be tested into the desired sample size and shape, benefit measurement cross section Then, the sample is trapped in the upper fixture of a constant-speed cross-head moving machine equipped with a dynamometer. The croissant is lowered to the initial exposure length, and the sample is connected to the fixed fixture 》 Then the sample is stretched under the strain of the moving speed, the stress-strain #training caused by Yijiyuan. The elongation is expressed as a percentage, and the tensile strength is measured in psi (test square inches) Kampong Tsao) said. P Bianxiangao This method can be applied to the measurement of the evacuation of the sharp piece. A bunch of first practice (200-800 nanometers) is passed through an americium in the quartz box containing the sharp piece in the dredging fluid . Measure the distance of the light from "Jin's Strike," and proportional to the incident (McCow) beam. Its The value is expressed in% light transmittance. Withdrawing the Jfe An Ding Jing Rui tablets in the hot pickaxe for 30 minutes, the clocks that haven't been treated with thermal tungsten have a slight loss of micro-dyeing strength. 薅 此Repeat the sequence 5 times, without losing the slightly dyed money, it is considered to pass this test. 箭 制 1 Dedicated to the iLA of UEMA: A1 in a 500 ml round bottom flask, place 350 ml of 5% K2C03 Dredging liquid. Add 0.10 (13.0g) of HEMA and add 10 cents pounds of Zie mud mixture. Add 0.08 (51.0 g) of Moer RB4 to the above solution. Yu Qi material completely -14-................ installed ................ ordered ......... .Line • f ((Please read the precautions on the back before filling in this page) This paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) A7 B7 printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economy V. Inventions Explanation (13) After the teaching, increase the degree to the threshold of 40-50 * €. Use the chromatographic HPLC method described in Hanggi et al., Analytical Biochemistry IM, 91-104 (1985) to track this reaction. Based on the technique of chlorinated triphenylene, chenke, and monosexual drunkenness. Using this method, the formation of mono-substituted monochlorotris " 丼 -HEMA polymerizable dye was seen at about 42 minutes. 0 After 40-50 hours, when sufficient conversion has been achieved, the reaction mixture can be passed through and collected, and Lujing 1 can be dried. The “self” can be used to lightly dye the sugar-shaped Yu Rui 0 The filtrate can be stripped by rotary evaporation black bypass to remove water from the reaction product. 0 The remaining blue powder can be used for micro-element tablets. Inorganic compounds can be removed according to the requirements of micro-element. Conversion rate of A-based three-p well, It can be increased by lowering the amount of water in the reaction compound. This will also increase the amount of the decoy derivative of the dye. 耆 裥 2 鈳 舻 舻 諻 誔 服 篇 ▲ The anti-lubricity »shaking RB4: synthesis 2 The reaction of the fans can be carried out in the following way, and about 85% of the mono-functional dichloro monochloro-HEMMA polymerizable dye is obtained. In a two-liter three-collar jacket washing bottle equipped with a mechanical stirring device Before adding the reagents, the cooling mushroom temperature should be set to 22 ° C), placing 497.2 g (27.62 mol) of water and 9.95 g (0.0721 mol) of K2CO3UCS grade, Aldrich # 20,261-9) «» in Jujia Before other reagents, make this solution equilibrate to 22 < > c. The reaction temperature should be controlled by the seal, and the wiping agent should be added at the same time. The pH value of the upper fan solution is maintained at 10-12. 497.2 g is added to this solution (3.82 Didou) Highly purified HEMA (0.1263%) EGDMA and 0.0275% MAA, as the quality, Rhoi Tech Mhoroier BM-920; this compound should be balanced to 22 * C. Add -15 -... ............. installed ................... order ----------: ---: (line (please Please read the precautions on the back before filling out this page) Use China National Standards (CNS) A4 specification (210X297 male cage) 297830 A7 B7 V. Description of invention (14) Print all 76.5 grams (0.120 mils) RB # 4 of the Employee Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs to make this dredged solution Tighten for 30 minutes, or until all groups have been eliminated. The reaction intensity of the compound was increased to 40 × :, and the disappearance of the bee was absorbed by HPLC seal control rib # 4. When the absorption of RB # 4 is less than 3% of the area of all chromophore bees (about 170 hours), the compound of the reaction mixture is neutralized with a soup solution of Kang 1 (40: 1). 8 Plant about 6.5 to 7.0. Stir for 30 minutes and pass through. The sifter was transferred from the Buchner funnel to the dried mushrooms and allowed to dry. The mortar and pestle stick "can be washed with Et20, EtOH, C-phase or CH30H as appropriate to remove any organic qualities, such as DMA, MΔ ▲ or ethylene glycol. 3 After blending to HEMA's anti-reflection mask A oblique RB4: Prepare A. 3 Add 76.5 grams of reactive blue # 4 and 450 grams of deionized water to a one-liter wash bottle. Place the content field under the room curtain for 30 minutes. Add 497.5 T-base two cockroic acid ethyl acetate (HEMA) to the bottle. The contents of Fang are now 20 points. Then, the lacquer added 12.7 mineralized acid_ dredging solution in deionized water. The contents of the prickly heat were heated to 40eC for 96 hours. The thallium meeting compound is neutralized with 2.5N sulfuric acid to pH 6.5. Cool the contents of this bottle to 5X: for 24 hours. The product is filtered through the empty field. Pixie_Xi's country is floating in 100g of a solution made from 50g of deionized water and ethyl alcohol (ethyl) alcohol. The product was taken by Lu Tian and harvested. The product of this minnow was floated in 100g of reagent (ethyl) brewing, and it was collected by passing through Lulu. This product was dried under the air gap of Xuan Yuan and <1 mm Hg. The product of this synthesis yields 19.9 blue-filled powder, which when analyzed by HPLC * obtains a separate absorption moo. 16-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 Gong Chu). Please read the notes before filling in the binding line. A7 B7 printed by the employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs. ) 耆 # 1 4 觎 曲 合 到 HEΜΑΙΑ Tortoise demolition RB4: 厶 出 4 In a one-liter wash bottle, add 75 grams of reactive blue # 4, and 572.5 grams of deionized water β to concentrate the contents in the chamber. 30 minutes. Pour 187.5 of prefacile f-yl propionic acid ethyl acetate (HEMMA) into the round bottle, and the contents of the mixture were mixed for 20 minutes. To this solution was added 11 grams of 50% dysprosium oxide marginal fluid. The contents of 蓊 lie under the room and stir for one hour. The Λ compound was neutralized to pH 6.5 using 2.5N acid. The contents of this flask are cold-belled to 5X: 24 hours, the products of Liaoyuan are collected by filtration and harvested. The sleep of Hansu Kanze «floats in a solution filled with 100 grams of deionized water and reagent (ethyl) alcohol. The product of Sui was taken by Lu Tian to harvest. The powdered turtle produced by washing the minnow was floated in 100 g of trial alcohol (ethyl) alcohol, and collected by filtration through Yijinjin. This product was dried under the air of Xuan Pin and 1 mm Hg. The product of this synthesis yielded 17.2 grams of blue powder, which obtained a separate absorption peak when analyzed by HPLC. f # 1 5 A is combined with HEMA's anti-lubricant RB4: Combine A 5 in a 100 ml wash bottle, add 9.0 g of reactive black # 5 (Re * azol; t color B, cas 17095-24-8) With 57.2 grams of deionized water, the contents were combined for 30 minutes at t temperature. Add 18.7 g of Acyl-T-Procyloenzyme to the bottle. Wash contents for 20 minutes. Add 1.04 to 50% radon solution in the liquid. Stir the contents under the chamber for 1 hour and 20 minutes. The Λ compound was neutralized with 2.5N acid to a small pH of 6.0. The contents of the washing bottle were cooled to 5 ° C for 24 hours. The Qi plant is harvested by sifting and filtering the field. The product is dried under Xuan and at a sag of less than 1 mm Hg. The product of this synthesis, -17-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X 297 mm) ..................................... ....... tr ................ Line •. ({cPlease read the precautions on the back before filling this page) V. Description of the invention (16) A7 B7 The employee consumer cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs produced 0.52 grams of basket-colored powder, which obtained a separate absorption peak when analyzed by HPLC. A Youhuishui's teachings, brewing, BL, bell, and waste, will combine the ingredients to form a homogram grind: 58.08 parts HEMA, 0.71 parts EGDMA, 0. shame parts MAA, 0.14 parts Darocur 1173 , 0.07 as the polymerizable dyeing department synthesized in Example 3, and 40 copies of GBAE. When it is included in the stealth pickling plate, by exposing it to UV light, the upper fan compound is polymerized. 0 After the polymerization is completed, the clock piece made by Sugi is submerged in 0.50% after the polymerization is completed. Add 0.50% iLE-80 in 0.90% NaCl solution to the MLE-80 water dredging solution, or in it. When the temperature of the solution is between 60-70X: «, hesitates to make the Yulu in Shanglian dredging fluid. The optical properties of this wrinkle slightly dyed clock are shown in Table 1, as Example 1. For the purpose of comparison, a "non-stained lens, and a Λ film with a slightly dyed method using the method of application, the hiding of optical properties # shown in Table 1, individually as a control example ▲ Β〇. The sharp tablets that are not slowed down are made in substantially the same way as above, but the dyeing department is not used. The pro-chips made by using the method are prepared in the following manner. First, the unstained micro-stained sharp piece is soaked in an RB4 liquid containing 0.50% MLE-80, and then before the final hydration , Through the contact with the water gun, the RB4 mackerel is joined to the sharp piece that has been soaked. (Please read the precautions on the back before filling out this page) Binding. Order. Line-18-The paper size is suitable for S 0 home materials (CNS) A4 wire (21GX 297 mm) A7 B7 Employee consumption of the Central Standards Bureau of the Ministry of Economic Affairs Printed by the cooperative. 5. Description of the invention (17) Table 1. The optical properties of grade 1 micro-stained invisible eyeglasses. A. Jin Shuan Zi Zi Ting water content% 60 60 60 Air pressure 28 26 28 Tensile modulus, psi 36 36 34 Elongation,% 120 118 128 Tensile strength, psi 32 35 34 «Property minimum light rate% 85 85 85 The stability of micro-staining is — is the result shown in Table 1, which is the strain According to the improved method of the present invention, the microscopic optical property of # 覚 微 柒 stealth team mirror is the nature of the corresponding invisible sharp eye that is slightly stained by the corresponding unstained stealth ship and the method of use. The same "19-...............- I ....... installed -.................. ordered ... ...! :: Line. (((Please read the precautions on the back before filling in this page) This paper size is applicable to China National Standard (CNS) A4 specification (210X 297 mm)