TW203011B

TW203011B - Pharmaceutical composition of powdered ascorbic acid

Info

Publication number: TW203011B
Application number: TW80105264A
Authority: TW
Inventors: Biing-Horng Song
Original assignee: Biing-Horng Song
Priority date: 1991-07-08
Filing date: 1991-07-08
Publication date: 1993-04-01

Abstract

A pharmaceutical composition of powdered ascorbic acid comprising: L-ascorbic acid or its pharmaceutical composition in powder form; in which the constituent of L-ascorbic acid is applied topically to stanch bleeding.

Description

^03011^ 03011

五、發明説明（） A.發明背景：經濟部中央楳準局貝工消f合作社印製 1.此發明屬止血障礙部門，其更細分為止血功能評估、血小板異常、凝血素異常、和血栓栓塞異常。然局部使用抗壤酸粉末之凝也機轉並不落於内在（Intrinsic)或外在（Extrinsic)過程（Pathway)串級（Cascade)，因其對正常it液、不能製造凝血素2、7、9、1〇之肝病患者和不能製ΐς凝金素8或9之丘友病患者或癌症患者皆有用同量相同一秒鐘内止血效果。 2<現用於開刀止血之方法為電燒（CaUtery)，注射腎上腺素（epinephrine)，指壓（pres sure)和某些纖維泡沐（ fiber foam)。某些情況電燒能致組織壌死。腎上腺素、指壓和纖維泡7末對易流血趨向者無效。纖維泡泳可致血腫（Hematoma)。抗壞血酸能對擴散性徵血管出血和傳統無法控制之肝病，血友病、直腸肸門癌的出血流血之止金，和前述諸種類病人開刀後傷口出血之止血皆有一秒鐘止血的特殊功效。抗壤血酸能藉増加類型1初膠原信息核酸（Type 1 Procol lagen mRNA)以調整勝原（ Collagen)之合成，促進傷口癒合 CAther〇scler〇sis， 1 982 Jan : 41 (1) : 15-9)。 3.波尼〔Bourne)於1944年審閱缺乏抗壌血酸之壌血病早期文康，其出示埃及紙草上之象形文字古書為令人說服之證據，此病之特微為牙床流血和皮膚出血，且已存在於3 0 0 0年前。牙床和牙齒被組織埭疽侵犯後，立刻脚本紙ft尺度边用中Η國家標準(CNS)平4規格(210x297公龙) (請先間ift背而之注意事項孙碼寫木") 裝· .一"ST. 線- _ 2 經濟部中央梂準局貝工消#合作社印製 03011 Λ 6 ____l}_6_ 五、發明説明（）和腿劇痛，腿资變黑色，腿縮起，並復蓋著黑色斑點。當鼻出血時即為死亡之預先。（Bourne，G. Η. , 1 94 4，Proc. 11.3〇0.?^(1.，37,512)。派耐克（？3七113：11〇19 71記述老鼠眼晶 It (Eye Lens)，腎上腺（Adrenal)，腦（Brain)、睪丸CTestis)和血液（Blood)之扰壌血酸casc〇rbic acid)濃度隨年岭之増加而減少。（Patnai|^，B.K.，197l ，Gerontologia，17, 122)，紫斑和舌下出金在年老人常見。於是本人想為何不將抗壤金酸磨成粉末或製成粉末，直接施於局部出金之止無，結果先實驗於本人卻一秒鐘内見效。 B.發明說明： 1. L-抗埭血酸（L-ascorbic acid)或其系統上名稱〔systematic name) L— 蘇— 2,3,4,5,6 — 戊氩軋基一 2 — d. # — 4 — ^ ；ί| CL- threo — 2,3,4,5,6 — pentahy- droxy 一 2 — hexenoic. acid一 4 — Lactone)，其係白色結晶狀固體〔White, crystalline solid)，溶解點（ melting Point)為 l920(Crawfords，198 0，Adv. in Carbohy· Chem. and Biochem.，Vol.3 7 , 8 4)。結晶體為堅硬之固體，且具定數墾硬之尖角，此不但抗壌血酸諸为、子之表面積（Surf ace areas)小，致不足以與金紅素（ hemoglobin)分子及灰漿蛋白質Cplasma proteins)發生化學作用，且其堅硬尖角易使傷口組織受傷刺痛。本發明觀念係於1 98 6年一月，余將此藥之物理方面改良以 (請先閲讀背面之注意市項洱塥寫木頁) 裝· 線· 本紙张尺度边用中困國家櫺準(CNS) f 4規格(210χ2974|) 画 3〜 ^03011 Λ (; I? 6 五、發明説明（）増加其表面積至最大以致於可充份地表露此抗壤血酸分子與血紅素和盗漿蛋白質分子作用，以期使其止血功能作用和迷度達到最高點，故本人將通常由D — glucose C D —葡萄糖）合成之L — ascorbic acid的結晶固艘磨成粉末或將美國製Nature^台色之每片5 〇〇 mg純L-ascorbic acid磨成粉末以増大其表面猜（surf ace areas )至最大而生立見止血之突破，並促傷口癒合。抗壌血酸之合成方法很多，概而言之，最重要工業上成本低之原料為D —葡萄糖（D — glucose)。 C^HOηΑ2〇η ! HOC* Η Η^ΟΗη!：5V. Description of the invention () A. Background of the invention: Printed by the Beigongxiao F Cooperative of the Central Bureau of Economics of the Ministry of Economic Affairs 1. This invention belongs to the department of hemostatic disorders, which is further subdivided into assessments of hemostatic function, platelet abnormalities, lectin abnormalities, and thrombosis The embolism is abnormal. However, the local use of anti-phosphoric acid powder coagulation also does not fall into the intrinsic (Extrinsic) or Extrinsic (Pathway) Cascade, because it cannot produce prothrombin 2, 7 , 9, 10 patients with liver disease and Qiuyou disease patients or cancer patients who can not produce lectin 8 or 9 have the same amount of hemostatic effect within one second. 2 < Currently, the methods used for hemostasis by surgery are electrocautery (CaUtery), injection of epinephrine (epinephrine), finger pressure (pres sure) and certain fiber foams (fiber foam). In some cases, electric burns can cause tissue death. Epinephrine, finger pressure and fibrous vesicles are not effective for those who are prone to bleeding. Fiber foam swimming can cause hematoma (Hematoma). Ascorbic acid can have a special effect of one-second hemostasis on hemorrhage and bleeding of diffuse vascular hemorrhage and traditionally uncontrollable liver disease, hemophilia, rectal pelvis cancer, and hemorrhage of wounds of the aforementioned types of patients after surgery. Ascorbic acid can add Type 1 Procol lagen mRNA to adjust the synthesis of Collagen and promote wound healing CAther〇scler〇sis, 1 982 Jan: 41 (1): 15-9 ). 3. Pourne (Bourne) reviewed the early Wenkang disease in the absence of anti-ascorbic acid in 1944. The ancient book of hieroglyphs on Egyptian papyrus was persuasive evidence. The disease was minimally bleeding in the gums and skin Bleeding, and it had existed 3000 years ago. Immediately after the gums and teeth are invaded by tissue gangrene, immediately use the script paper ft scale to use the Chinese National Standard (CNS) flat 4 specifications (210x297 male dragons) (please pay attention to the ift and write the code before the sun). · .1 " ST. Line-_ 2 Printed by the Ministry of Economic Affairs, Central Bureau of Industry and Technology #Cooperatives 03011 Λ 6 ____ l} _6_ V. Description of the invention () and severe leg pain, the legs become black, the legs are retracted, And covered with black spots. When the nose bleeds, it is the advance of death. (Bourne, G. Η., 1 94 4, Proc. 11.3〇0.? ^ (1., 37,512). Pine Nike (? 3 VII 113: 11〇19 71 describes the mouse eye lens It (Eye Lens), adrenal glands (Adrenal), brain (Brain), testicle (CTestis) and blood (Blood) concentration of cascorbic acid decreased with the increase of Nianling. (Patnai | ^, B.K., 197l, Gerontologia, 17, 122), purple spots and sublingual gold are common in young people. Therefore, I thought why I did not grind the anti-fouling auric acid into powder or make it into powder, and directly applied it to the local gold production. The result was that the experiment first worked for me within one second. B. Description of the invention: 1. L-ascorbic acid or its system name (systematic name) L—Su—2,3,4,5,6—pentargon rolling base 2—d . # — 4 — ^; ί | CL- threo — 2,3,4,5,6 — pentahy- droxy one 2 — hexenoic. Acid one 4 — Lactone), which is a white crystalline solid [White, crystalline solid) , The melting point (melting point) is l920 (Crawfords, 198 0, Adv. In Carbohy. Chem. And Biochem., Vol. 3 7, 8 4). The crystal is a hard solid and has a number of sharp corners. This not only has anti-ascorbic acid actions and small surface areas (Surf ace areas), so it is not enough to interact with hemoglobin molecules and mortar proteins (Cplasma proteins) Chemical action occurs, and its hard, sharp corners are prone to hurt and sting wound tissue. The concept of the present invention was in January 1986, and the physical aspects of this medicine were improved (please read the note on the back of the page to write a wooden page). (CNS) f 4 specifications (210χ2974 |) Painting 3 ~ ^ 03011 Λ (; I? 6 V. Description of the invention) Increase its surface area to the maximum so that it can fully expose this anti-sorbic acid molecule, heme and thief The role of plasma protein molecules in order to achieve the highest point of hemostasis function and ambiguity, so I will grind the solid crystal of L-ascorbic acid, which is usually synthesized from D-glucose CD-glucose), into a powder or convert the US-made Nature ^ Taiwan Each piece of Sezhi 500 mg pure L-ascorbic acid is ground into a powder to increase its surf ace areas to the maximum and create a breakthrough in hemostasis and promote wound healing. There are many ways to synthesize ascorbic acid. In summary, the most important raw material with low industrial cost is D-glucose (D-glucose). C ^ HOηΑ2〇η! HOC * Η Η ^ ΟΗη !: 5

CJH0 OH fceH20H vN 8 CffH2〇HCJH0 OH fceH20H vN 8 CffH2〇H

本紙張尺度逍用中國國家標率(CNS)甲4規格(210x297公徒) (請先閱讀背而之注意事項#蜞菸木"--" 裝· 線·This paper scale uses the Chinese National Standard Rate (CNS) A4 specifications (210x297 gong) (please read the backing notes first # 蜞烟木 "-" 装 · 线 ·

^03011^ 03011

五、發明説明（） D-葡萄糖變成Ϊ有分別兩遇程，其—係D—葡萄糖之經濟部中央楳準局EX工消费合作社印製第-個破⑹變成！之第六個破，另一係』—葡萄糖之第一個硖變成I之第一個破。壯钱此兩者過程皆成由D —葡萄糖合成L—抗壌血酸；前者“〇D—葡萄糖之第一個破必須受遣原及第五和第六個破受氣化而變成…沖 —heXulosonic acid，其 lact〇nizati〇n (内脂化）即變成I。當D —葡萄糖變成j沒經轉換整個碳鏈（Carb〇n Chain )時，D —葡萄糖（扑欠第一個和第二個硖必須受氧化，而第五個破必須倒轉，此為另—合成L —抗壌血酸之步驟。（Crawfords，19 8 0，Adv. inCarb〇hy· Chem· and Biochem’ Vol.37，85·86)工業上最實用之合成法係利器斯旦一古如斯納合成法（Reichstein_ Grussner Synthesis)和其中之一步驟創新之員斯佛特(Bassford)合成法。（(^£对;5〇『£18，198 0，厶(^.;111〇31：-bohy· Chem. and Biochem.， Vol 37,89-105) ⑴利器斯旦一古如斯納合成法：將 D —葡萄糖也化〔hydrogenation)成 D — glucitol (Sorbitol)C花楸醇），其被細菌醋_屬〔Bacterium Xylinum 或 acetobacter Xylinum)氣化變成 L—Xylo— 2 — hexulopyranose ( L — Sorbopyranose)(花楸糖），其在硫駿之下與丙酮（acetone)作用變成2， :4,6 di 0 i sopropy lidene — L — Xyl〇 2 — hexulofuranose，其被過錳酸鉀氧化變成相當之本紙張尺度边用中國《家楳準(CNS) «Ρ4規格(210x297公龙） (請先間讀背而之注意苹項#堝寫木奸) /r V -^ - 訂- 顯 5 203011 A 6 Η 6 經濟部中央樣準局兵工消費合作杜印褽五、發明説明（）酸，其與水加熱變成L — Xy 1〇 — 2 — hexulosonic acid,其與水加熱至1〇〇。或將其醋化變成1^1;1^1^一 Xylo — 2 — hexulosonate 後與甲基氧化納（Sodium methoxide)於甲醉（methanol用然後以氟化氩氟體駿化即得L — ascorbic acid ;本人之製法係將此所得之L — ascorbic acid結晶體放在濾紙上，用抽水機（water aspirator)在室溫中將其乾燥，然後磨成粉末，.不續製成錠片。 ⑵貝斯佛特合成法：在利器斯旦一古如斯納法中，將2,3:4,6 — Di — 0— isopropylidene — L — Xylο — hexulofuranosonic acid, L — Xylo — 2 — hexulosonic acid 或 Me thy L — Xylo — 2 — hexulosonate 於溶劑諸如笨 C benzene)，氣化笨（Chlorobenzene)，四象化 C* 炫（ tetrachloroethane)或含濃造酸之甲笨（t〇luene)中加熱，L —抗壤血酸從混合物中沈滅·下來。本人之發明係將此沈澱物上層之水溶液倒掉，然後將剩下之沈派物用Labconco Freeze dry於真空，零下5〇0C和ίο 大氣壓下冷凍乾燥而得乾燥之L一抗壤血酸結晶狀固體，並將此結晶狀固體磨成粉末即得，不績製成錠片。 2.動物實驗及臨床實例照片說明：此可口服及肌肉注射之抗壞i酸係抗軋化劑，有聚合細胞及促進組織癒合和抗壌血之作用。本人發明此粉末局 (請先間讀背而之注意事項#码寫木页) 裝- 訂_ 線· 0 本紙》尺度边用中明Η家搮準(CNS) «Ρ4規格(210x297公徒） 6〜五、發明説明（）都嘴用，有強烈之止血作用，對任何疾病之▲液皆同。使用足量〔每〇：·之血需0·1568泖之扰壤金酸粉末，可於外科開刀中，開刀後，牙科開刀，拔牙，内科胃出金及任何外傷之強烈止血。此粉末與▲液作用後變成黑色联狀體，後變成固狀凝固’尤其開刀中擴散性做成管流血或因割錯较大動脈失控轰崩&找不到以時，足量局部使用使之止錢命。動物實驗中，鼠股動脈，甚至頸動脈切蛴之汹湾流血都可一秒鐘之内止血（請見附上照片一號和二號箭指處）靜脈切斷一秒鐘内止血，立即變呈黑膠C照片二號），微血管切斷一秒鐘内止血，立即呈黑膠C照片五號）將老鼠注射Histamin促分泌胃酸後剖腹打開胃部刮其黏膜層c照片六號）引起胃出也（照片七號），則止血呈黑膠狀C照片八號）但较慢止血，故可用此藥粉服用助胃出血病人止血，臨床證明開刀中大量流企可止金，不管患何種疾病之人皆同。例㈠32.歲，男，頭皮瘤開刀汹湧出丘（照片九號〕，嘴入此粉則助其止血（照片十號）。例㈡40.歲，女，急性腎臟衰竭，開刀做動靜脈連接術，谷易大量流血，（照片十一號）藥粉放下時，黑色為凝血起作用，白色為橥未與血液混合（照片十二號）然後橥粉更加與血液混合C照片十三號），然後將黑色凝結膠狀用紗布沾及用Ringer ’ s生理盈水洗一下，即成（照片十四號）前後共5分鐘，術後本紙張尺度逍用中B Η家楳準(CNS) TM規格（2 ΚΙ X 297公龙) 經濟部中央楳率局β工消费合作社印製幺〇3〇ϋ _ Λ (5---------- η 6 _ 五、發明説明（）病人情況特好。二）歲’男’手掌皮膚.擎綿（contracture)，須要割掉，移植手上皮膚，將手上皮膚割下一大塊時大量〜灰C照片十五號），後施用此藥粉至流血處，即與血液接觸者立即凝血呈黑色凝固，白色為未與血液混合者C照片十六號），繼續缝合（照片十七號)。，例㈣7ft歲，女，肛門周圍狼艘，切開時流也（照片十八號）施燊粉後立即凝血呈黑膠狀，白色為未與金液混合起作用之藥粉（照片十九號）開始缝合C照片廿號）。例㈤男，50.歲，肛門周固狼腫，切開時流血汹汹（照片廿號）’喷橥後’呈黑色凝，白色為未與血液· 混合作用之瞬間C照片廿二號），縫合（照片廿三號）’最後塞入長布帶c照片廿四號）。例㈥男，30.歲，拔牙時，牙床流血（照片廿五號），施藥艾即—秒鐘内止金（照片廿六號），半分鐘後擦掉黑色凝膠，仍不出血（照片廿七號）。例⑹女，6Q歲，肝硬化’拔牙時，流血汹湧不止（照片廿八號）施藥粉後’ 一秒鐘内呈黑色止金（照片廿九號）例（A)自己，手指小刺傷（照片卅號），沾藥後（照片砷一號）》想外試管中實驗證明每1江血液需要〇1568 冬紙張尺度ΑΛΙ中8 β緖雜NS) Ή腦(210x297公;¢) ~~"" _ 〜8〜 (請先閲讀背而之注意事項#堝艿木抒) 裝· 線- 驪 £03011 Λ 6 η 6 五、發明說明（）克抗壌血酸粉末，並須混合，需6分鐘凝結正常、肝病、大腸癌和血友病之血液皆同藥量亦同時’故與凝血素無闞。照片卅二號正常人，照片卅〜號癌症，照片_四號灰友病，病人為王世健，男，自願*身份證號8121?45233,住高雒市楠梓區壽民略1〇〇巷5號’王世健生於55年8月5日。例（九） v % 如前述傲外試管中凝血，凝者呈黑膠狀： ⑴矶歲，男，正常，照片卅二號。 (2) 50.歲，女，大腸癌，照片卅三號。 ⑶25·歲，男，金友病，照片卅四號。血友病之兩試管中無放藥粉者永不凝血，金球亦永不沈澱於血漿之下。 (請先閲讀背而之注意事項#艰筠木IK) 裝. 線· 經濟部中央標準局只工消費合作社印製Fifth, the description of invention () D-glucose turns into Ϊ. There are two separate encounters. It is printed by EX-Consumer Cooperative of the Central Department of Economics of the Ministry of Economic Affairs D-glucose. The sixth is broken, the other is-the first knot of glucose becomes the first broken of I. The two processes of making money both become the synthesis of L-ascorbic acid from D-glucose; the former "〇D-the first break of glucose must be dismissed by the original and the fifth and sixth breaks by gasification and become ... heXulosonic acid, its lact〇nizati〇n (lipidation) becomes I. When D — glucose becomes j without converting the entire carbon chain (Carb〇n Chain), D — glucose (the first and second owes Each knot must be oxidized, and the fifth one must be reversed. This is another step of synthesizing L-ascorbic acid. (Crawfords, 19 8 0, Adv. In Carbonohy · Chem · and Biochem 'Vol. 37, 85 · 86) The most practical synthesis method in the industry is the sharp weapon Stan-Grussner Synthesis method (Reichstein_Grussner Synthesis) and one of the steps of innovation, the Sford (Bassford) synthesis method. ((^ £ pair; 5〇 £ 18,198 0, Ji (^ .; 111〇31: -bohy · Chem. And Biochem., Vol 37,89-105) ⑴Stone-Stone-Gurusner synthesis method: D-glucose It also turns into hydrogenation (D — glucitol (Sorbitol) C), which is bacterium vinegar _ genus (Bacterium Xylinum or acetobacter Xylinum ) Gasification becomes L—Xylo— 2 — hexulopyranose (L — Sorbopyranose) (rowan sugar), which under thiosulfan and acetone (acetone) becomes 2,: 4,6 di 0 i sopropy lidene — L — Xyl 〇2 — hexulofuranose, which is oxidized by potassium permanganate to the equivalent of the original paper scale, using the Chinese "楳楳准 (CNS)« P4 specification (210x297 male dragon) (please read back and pay attention to the apple ## write Mukan) / r V-^-Ding-Xian 5 203011 A 6 Η 6 Ministry of Economic Affairs Central Sample Bureau Ordnance Industry Consumption Cooperation Du Yin r. V. Invention description () Acid, which becomes L — Xy 1〇 when heated with water 2 — hexulosonic acid, which is heated with water to 100. Or vinegar it into 1 ^ 1; 1 ^ 1 ^ -Xylo — 2 — hexulosonate and sodium methoxide in sodium methoxide Then L-ascorbic acid is obtained by argon fluoride fluoride; my method is to put the obtained L-ascorbic acid crystal on the filter paper, use a water aspirator to dry it at room temperature, and then grind Into powder, not to be made into tablets. ⑵Bethfurt synthesis method: In the sharp weapon Stan-Old Rusner method, 2,3: 4,6 — Di — 0— isopropylidene — L — Xylο — hexulofuranosonic acid, L — Xylo — 2 — hexulosonic acid or Me thy L — Xylo — 2 — hexulosonate is heated in solvents such as stupid C benzene, gaseous stupid (Chlorobenzene), tetrahedral C * (chlorochloro) or toluene containing concentrated acid, L -Anti-serum acid sinks from the mixture. My invention is to pour off the aqueous solution of the upper layer of the precipitate, and then freeze the remaining sediments in Labconco Freeze dry under vacuum, minus 50 ° C and at atmospheric pressure to obtain dry L-anti-serum acid crystals Solid and grind this crystalline solid into powder, which can be made into tablets. 2. Photo description of animal experiments and clinical examples: This ascorbic acid-based anti-rolling agent, which can be taken orally and intramuscularly, has the effect of polymerizing cells and promoting tissue healing and anti-hemorrhage. I invented this powder bureau (please read back and note #code to write a wooden page in advance) Binding-Order _ Line · 0 This paper "standard side use Zhongming Η family 揮准 (CNS)« P4 specification (210x297) 6 ~ V. Description of the invention () It is used for mouth, it has a strong hemostatic effect, and it is the same for any disease. Use a sufficient amount [0.18568 per hour of the blood of turbidium auric acid powder for every blood: can be used in surgical operations, after surgery, dental surgery, tooth extraction, internal medicine stomach extraction and any trauma to strongly stop bleeding. This powder and ▲ liquid will become black conjoined body after the action, and then become solid coagulation. Especially in the operation, the diffusivity is made into a tube to bleed or the arteries are out of control due to large cutting errors. When not found, sufficient local use Only money life. In animal experiments, rat femoral arteries, even carotid arteries cut into the turbulent bay of bleeding can stop bleeding within one second (see the attached photos at the first and second arrows). The vein is cut off and hemostasis within one second, immediately changing Presented with vinyl C photo No. 2), microvessels cut off within one second to stop bleeding, immediately presented with vinyl C photo No. 5) mice were injected with Histamin to promote secretion of gastric acid, and the stomach was opened by laparotomy. Chuya (Photo No. 7), the hemostasis is black gel C photo No. 8) but slower hemostasis, so this powder can be used to help patients with gastric bleeding to stop bleeding, clinically proved that a large number of abortions in the operation can stop the money, no matter what Everyone is sick. Case ㈠ 32. years old, male, scalp tumor surged out of the mound (photo No. 9), the mouth into this powder to help hemostasis (photo No. 10). Example ㈡ 40. years old, female, acute kidney failure, surgery for arteriovenous connection , Gu Yi bleeds a lot, (Picture No. 11) when the powder is put down, black is for coagulation, white is not mixed with blood (Picture No. 12) and then the powder is mixed with blood (Photo No. 13), then Dip the black coagulated gel with gauze and wash with Ringer's physiological surplus water. Serve (Photo No. 14) for 5 minutes before and after. The paper size is used in the post-operative period. B Η 家楳准 (CNS) TM specifications ( 2 ΚΙ X 297 Gonglong) Printed by the β-Consumer Cooperative of the Central Bureau of Economics of the Ministry of Economic Affairs _ Λ (5 ---------- η 6 _ V. Description of the patient () Good. 2) The skin of the palm of the old 'male' palm. The contracture needs to be cut off and transplanted to the skin of the hand. When the skin of the hand is cut into a large piece, a large amount of ~ C gray photo No. 15), and then apply this powder To the bleeding place, that is, those who come into contact with blood immediately coagulate in black and coagulate, and white is not in contact with blood Photos were mixed C 16th), continue sewing (Photo 17th). , Example ㈣7ft years old, female, wolf ship around the anus, when the incision flow (photo No. 18) immediately after applying the powder, blood clots immediately into a black gel, white is the powder that does not work with the gold liquid (photo No. 19). Stitch the C photo (20). Example (male), 50 years old, with perianal wolves in the anus, bleeding violently during incision (photo No. 20), 'black after spraying', black clot, white is the moment when it does not mix with blood · C photo No. 22), suture (Photo No. 23) 'Finally put the long cloth tape c photo No. 24). Example ㈥Male, 30. years old, bleeding gums during tooth extraction (photo No. 25), after applying Ai, it stops within one second (photo No. 26), wiped off the black gel half a minute later, and still did not bleed ( Photo twenty-seven). Example ⑹ Female, 6Q years old, with liver cirrhosis 'Bleeding is more and more violent during tooth extraction (Photo No. 28) After applying powder', black stop gold within one second (Photo No. 29) Example (A) Self, small finger Stabbing (Photo No. 30), after taking the medicine (Photo Arsenic No. 1) "I want to test in an external test tube that every 1 river of blood requires 〇1568 winter paper standard ΑΛΙ 8 β 編杂 NS) Ή Brain (210x297 g; ¢) ~ ~ " " _ ~ 8 ~ (please read the back of the precautions # 锅艿木寫) 装 · 线-骊 £ 03011 Λ 6 η 6 Fifth, the invention description () grams of anti-ascorbic acid powder, and must Mixed, it takes 6 minutes to coagulate the blood of normal, liver disease, colorectal cancer and hemophilia. Photo 32 normal person, photo 30 ~ cancer, photo _ gray friend disease No. 4, the patient is Wang Shijian, male, voluntary * ID number 8121? 45233, live in Lane 100, Shouminlu, Nanzi District, Gaoluo City No. 5 'Wang Shijian was born on August 5, 55. Example (9) v% As described above, the blood clotting in the test tube is proud, and the coagulated blood is black gel: ⑴Isui, male, normal, photo 32. (2) 50. years old, female, colorectal cancer, photo thirty-three. ⑶ 25 · year-old, male, Jinyou disease, photo thirty-four. In the two test tubes of hemophilia, those without drug powder will never coagulate, and the golden balls will never settle under the plasma. (Please read the back of the precautions #IKanmu IK) installed. Thread · Printed by the Ministry of Economic Affairs, Central Bureau of Standards, only at the Consumer Cooperative

99