TW202408514A - 用於治療癌症的表皮生長因子受體酪胺酸激酶抑制劑 - Google Patents

用於治療癌症的表皮生長因子受體酪胺酸激酶抑制劑 Download PDF

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Publication number
TW202408514A
TW202408514A TW112112431A TW112112431A TW202408514A TW 202408514 A TW202408514 A TW 202408514A TW 112112431 A TW112112431 A TW 112112431A TW 112112431 A TW112112431 A TW 112112431A TW 202408514 A TW202408514 A TW 202408514A
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TW
Taiwan
Prior art keywords
pharmaceutically acceptable
acceptable salt
egfr tki
egfr
administered
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Application number
TW112112431A
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English (en)
Chinese (zh)
Inventor
尼古拉斯 弗洛克
馬修 喬瑟夫 馬丁
保羅 大衛 史密斯
烏蘇拉 格拉齊尼
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瑞典商阿斯特捷利康公司
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Publication of TW202408514A publication Critical patent/TW202408514A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW112112431A 2022-03-31 2023-03-31 用於治療癌症的表皮生長因子受體酪胺酸激酶抑制劑 TW202408514A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263325861P 2022-03-31 2022-03-31
US63/325,861 2022-03-31

Publications (1)

Publication Number Publication Date
TW202408514A true TW202408514A (zh) 2024-03-01

Family

ID=86007676

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112112431A TW202408514A (zh) 2022-03-31 2023-03-31 用於治療癌症的表皮生長因子受體酪胺酸激酶抑制劑

Country Status (11)

Country Link
US (1) US20250205233A1 (enExample)
EP (1) EP4499102A1 (enExample)
JP (1) JP2025510910A (enExample)
KR (1) KR20240168418A (enExample)
CN (1) CN119278041A (enExample)
AU (1) AU2023246862A1 (enExample)
CA (1) CA3255389A1 (enExample)
IL (1) IL315848A (enExample)
MX (1) MX2024011959A (enExample)
TW (1) TW202408514A (enExample)
WO (1) WO2023187037A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20250538A (es) * 2023-05-26 2026-04-21 Astrazeneca Ab Composiciones farmacéuticas
KR20260024838A (ko) * 2024-08-14 2026-02-23 경희대학교 산학협력단 프로토사파닌 b 및 오시머티닙을 유효성분으로 포함하는 폐암의 예방 또는 치료용 조성물

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DE10063435A1 (de) 2000-12-20 2002-07-04 Boehringer Ingelheim Pharma Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
HRP20110958T1 (hr) 2004-05-06 2012-01-31 Warner-Lambert Company Llc 4-fenilaminokinazolin-6-ilamidi
TW200736260A (en) 2005-11-10 2007-10-01 Smithkline Beecham Corp Inhibitors of Akt activity
UA95641C2 (xx) 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
BRPI0818533B8 (pt) 2007-10-11 2021-05-25 Astrazeneca Ab composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto
US8481503B2 (en) * 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
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DK3686193T3 (da) 2011-07-27 2022-05-30 Astrazeneca Ab 2-(2,4,5-substitueret anilino)pyrimidinforbindelser
SG11201401953WA (en) 2011-10-31 2014-09-26 Betta Pharmaceuticals Co Ltd Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof
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LT2964638T (lt) 2013-03-06 2017-12-27 Astrazeneca Ab Epidermio augimo faktoriaus receptoriaus aktyvinančių mutacijų formų chinazolino inhibitoriai
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Also Published As

Publication number Publication date
JP2025510910A (ja) 2025-04-15
IL315848A (en) 2024-11-01
AU2023246862A1 (en) 2024-10-31
EP4499102A1 (en) 2025-02-05
CA3255389A1 (en) 2023-10-05
WO2023187037A1 (en) 2023-10-05
US20250205233A1 (en) 2025-06-26
MX2024011959A (es) 2024-12-06
KR20240168418A (ko) 2024-11-29
CN119278041A (zh) 2025-01-07

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