TW202405401A - flow method - Google Patents
flow method Download PDFInfo
- Publication number
- TW202405401A TW202405401A TW112122804A TW112122804A TW202405401A TW 202405401 A TW202405401 A TW 202405401A TW 112122804 A TW112122804 A TW 112122804A TW 112122804 A TW112122804 A TW 112122804A TW 202405401 A TW202405401 A TW 202405401A
- Authority
- TW
- Taiwan
- Prior art keywords
- solid
- liquid
- solids
- liquids
- separation
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 40
- 239000007787 solid Substances 0.000 claims abstract description 113
- 239000007788 liquid Substances 0.000 claims abstract description 108
- 238000000926 separation method Methods 0.000 claims abstract description 69
- 239000000203 mixture Substances 0.000 claims abstract description 35
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 15
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims description 35
- 230000007246 mechanism Effects 0.000 claims description 32
- 239000002904 solvent Substances 0.000 claims description 29
- 239000006228 supernatant Substances 0.000 claims description 16
- 239000006185 dispersion Substances 0.000 claims description 14
- 238000001308 synthesis method Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 abstract description 8
- 230000008025 crystallization Effects 0.000 abstract description 8
- 238000001914 filtration Methods 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 238000007670 refining Methods 0.000 abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 13
- 239000002002 slurry Substances 0.000 description 12
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 10
- 238000010924 continuous production Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 238000000746 purification Methods 0.000 description 6
- 238000006467 substitution reaction Methods 0.000 description 6
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 5
- 235000019341 magnesium sulphate Nutrition 0.000 description 5
- 238000011084 recovery Methods 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D12/00—Displacing liquid, e.g. from wet solids or from dispersions of liquids or from solids in liquids, by means of another liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/02—Crystallisation from solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
本發明係關於流動法。This invention relates to flow methods.
[背景技術] 持續檢討生產目標化合物時的合成連續化(連續生產)。然而，連續生產中，晶析步驟及過濾步驟的發展仍貧乏，目前是使用類似以往批次法的手法。 [Background technology] Continuously review the synthesis continuity (continuous production) when producing target compounds. However, in continuous production, the development of crystallization steps and filtration steps is still poor, and methods similar to the conventional batch method are currently used.
[發明概要] [發明欲解決之課題] 本發明之目的在於新提供一種流動法，其在連續生產中，可使晶析步驟、過濾步驟等精製步驟亦與合成步驟相同地連續化，藉此，從合成步驟至精製步驟就能連續生產。 [Summary of the invention] [Problem to be solved by the invention] The object of the present invention is to provide a new flow method that can continue the purification steps such as the crystallization step and the filtration step in the same manner as the synthesis step in continuous production, thereby enabling continuous production from the synthesis step to the purification step. .
[用以解決課題之手段] 本案發明人等為了解決前述課題反覆進行精心研討的結果，開發了一種流動法，其係藉由離心分離對包含固體及液體之混合物進行固液分離，藉此就能連續生產。 [Means used to solve problems] As a result of repeated and careful research to solve the above-mentioned problems, the inventors of this case developed a flow method in which solid-liquid separation of a mixture containing solids and liquids is performed by centrifugal separation, thereby enabling continuous production.
本發明包含以下所示之流動法。The present invention includes the flow method shown below.
項1.一種流動法，包含下述步驟：藉由離心分離將包含固體及液體之混合物分離成固體及液體， 前述分離步驟係以下述方式進行：連續供給包含固體及液體之混合物，並回收上清液而使固體沉澱。 Item 1. A flow method comprising the following steps: separating a mixture containing solids and liquids into solids and liquids by centrifugal separation, The aforementioned separation step is performed in the following manner: a mixture containing solid and liquid is continuously supplied, and the supernatant liquid is recovered to precipitate the solid.
項2.一種流動法，包含下述步驟：藉由離心分離將包含固體及液體之混合物分離成固體及液體， 前述分離步驟係以下述方式進行：連續供給溶解有固體之溶液與該固體之不良溶劑，調製包含已晶析之固體及液體的混合物，並回收上清液而使固體沉澱。 Item 2. A flow method comprising the following steps: separating a mixture containing solids and liquids into solids and liquids by centrifugal separation, The aforementioned separation step is performed in the following manner: a solution in which the solid is dissolved and a poor solvent for the solid are continuously supplied, a mixture containing the crystallized solid and the liquid is prepared, and the supernatant liquid is recovered to precipitate the solid.
項3.如前述項1或2之流動法，其包含下述步驟：於前述分離步驟之後，混合已沉澱之固體與該固體之不良溶劑來調製分散體，並回收該分散體。Item 3. The flow method according to Item 1 or 2 above, which includes the following steps: after the aforementioned separation step, the precipitated solid and the poor solvent of the solid are mixed to prepare a dispersion, and the dispersion is recovered.
項4.如前述項1至3中任一項之流動法，其包含下述步驟：於前述分離步驟後，連續供給溶劑而將溶劑取代。Item 4. The flow method according to any one of the above items 1 to 3, which includes the following steps: after the aforementioned separation step, the solvent is continuously supplied to replace the solvent.
項5.一種流動合成法，係於如前述項1至4中任一項之流動法中的前述分離步驟之前步驟或後步驟，包含固液反應步驟、氣液反應步驟、液液反應步驟或固固反應步驟。Item 5. A flow synthesis method, which is a step before or after the aforementioned separation step in the flow method of any one of the preceding items 1 to 4, including a solid-liquid reaction step, a gas-liquid reaction step, a liquid-liquid reaction step, or Solid reaction step.
項6.一種流動裝置，具備分離機構，該分離機構係藉由離心分離將包含固體及液體之混合物分離成固體及液體， 前述分離機構中，係連續供給包含固體及液體之混合物，並回收上清液而使固體沉澱。 Item 6. A flow device equipped with a separation mechanism that separates a mixture containing solids and liquids into solids and liquids through centrifugal separation, In the aforementioned separation mechanism, a mixture containing solid and liquid is continuously supplied, and the supernatant liquid is recovered to precipitate the solid.
項7.一種流動裝置，具備分離機構，該分離機構係藉由離心分離將包含固體及液體之混合物分離成固體及液體， 前述分離機構中，係連續供給溶解有固體之溶液與該固體之不良溶劑，調製包含已晶析之固體及液體的混合物，並回收上清液而使固體沉澱。 Item 7. A flow device equipped with a separation mechanism that separates a mixture containing solids and liquids into solids and liquids through centrifugal separation, In the aforementioned separation mechanism, a solution in which a solid is dissolved and a poor solvent for the solid is continuously supplied, a mixture containing the crystallized solid and the liquid is prepared, and the supernatant liquid is recovered to precipitate the solid.
項8.一種流動合成裝置，係於前述項6或7之流動裝置中的前述分離機構之前機構或後機構，具備固液反應機構、氣液反應機構、液液反應機構、或固固反應機構。Item 8. A flow synthesis device, which is a mechanism before or after the separation mechanism in the flow device of Item 6 or 7, and has a solid-liquid reaction mechanism, a gas-liquid reaction mechanism, a liquid-liquid reaction mechanism, or a solid-solid reaction mechanism. .
[發明效果] 本發明可新提供一種流動法，其在連續生產中，可使晶析步驟、過濾步驟等精製步驟亦與合成步驟相同地連續化，藉此，從合成步驟至精製步驟就能連續生產。 [Effects of the invention] The present invention can newly provide a flow method that can continue the purification steps such as the crystallization step and the filtration step in the same manner as the synthesis step in continuous production, thereby enabling continuous production from the synthesis step to the purification step.
[用以實施發明之形態] 以下詳細說明本發明。 [Form used to implement the invention] The present invention will be described in detail below.
用以展示本發明之實施形態係有關於能更好理解發明趣旨的說明，只要沒有特別聲明，發明內容不受其所限制。The embodiments used to demonstrate the present invention are descriptions that enable a better understanding of the gist of the invention. Unless otherwise stated, the invention is not limited by the contents.
本說明書中，「包含」及「含有」為蘊含以下任一者之概念：「包含(comprise)」、「實質上僅由…構成(consist essentially of)」、及「僅由…構成(consist of)」。In this specification, "comprise" and "contain" are concepts that include any of the following: "comprise", "consist essentially of", and "consist of )".
說明書中將數值範圍以「A~B」表示時，意指「A以上且B以下」。When the numerical range is expressed as "A~B" in the specification, it means "above A and below B".
[1]流動法及流動裝置 (1)固液分離步驟 本發明之流動法包含以下步驟：藉由離心分離將包含固體及液體之混合物分離成固體及液體(固液分離步驟)。 [1]Flow method and flow device (1) Solid-liquid separation step The flow method of the present invention includes the following steps: separating a mixture containing solids and liquids into solids and liquids by centrifugal separation (solid-liquid separation step).
本發明之流動法中，前述分離步驟係以下述方式進行：連續供給包含固體及液體之混合物，並回收上清液而使固體沉澱。In the flow method of the present invention, the aforementioned separation step is performed in the following manner: a mixture containing solids and liquids is continuously supplied, and the supernatant liquid is recovered to precipitate the solids.
本發明之流動法中，前述分離步驟係以下述方式進行：連續供給溶解有固體之溶液與該固體之不良溶劑，調製包含已晶析之固體及液體的混合物，並回收上清液而使固體沉澱。In the flow method of the present invention, the aforementioned separation step is performed in the following manner: a solution in which the solid is dissolved and a poor solvent for the solid is continuously supplied, a mixture containing the crystallized solid and the liquid is prepared, and the supernatant liquid is recovered to make the solid Precipitation.
包含固體及液體之混合物，例如為漿料(固體未溶解之溶液等)、飽和溶液(溶解有固體之溶液等)、過飽和溶液、懸浮有不溶物之溶液等。Mixtures containing solids and liquids, such as slurries (solutions in which solids are not dissolved, etc.), saturated solutions (solutions in which solids are dissolved, etc.), supersaturated solutions, solutions in which insoluble matter is suspended, etc.
離心分離中，可使用離心分離機(離心分離裝置)。就離心分離而言，例如，將漿料連續供給至離心分離機，藉由離心分離並利用離心力，使漿料中的固體沉降(沉澱)，而離心分離的結果，將漿料中的液體會成為上清液而被分離、回收。For centrifugal separation, a centrifugal separator (centrifugal separation device) can be used. In terms of centrifugal separation, for example, the slurry is continuously supplied to a centrifuge, and the solids in the slurry are settled (precipitated) by centrifugal separation and the use of centrifugal force. As a result of the centrifugal separation, the liquid in the slurry will be It becomes supernatant and is separated and recovered.
本發明之流動法中，係連續供給溶解有固體之溶液(飽和溶液)與該固體之不良溶劑，調製包含已晶析之固體及液體的混合物。本發明之流動法中，接下來會回收上清液並使固體沉澱。In the flow method of the present invention, a solution (saturated solution) in which a solid is dissolved and a poor solvent for the solid are continuously supplied to prepare a mixture containing the crystallized solid and the liquid. In the flow method of the present invention, the supernatant liquid is recovered and the solid is precipitated.
對於漿料等包含固體及液體之混合物進行溶劑取代，藉此可使漿料中的固體晶析，而進行精製。By performing solvent substitution on a mixture containing solids and liquids such as slurry, the solids in the slurry can be crystallized and refined.
以往，在連續生產中，以批次法進行的晶析步驟、過濾步驟等主流上是仰賴人來進行作業。In the past, in continuous production, most of the crystallization steps and filtration steps performed by the batch method relied on people to perform operations.
本發明之流動法，係藉由離心分離將漿料等包含固體及液體之混合物分離成固體及液體，可分別回收固體及液體。本發明之流動法可發揮優異之混合、擴散效率，甚至連晶析步驟都可更有效率地進行。本發明之流動法可降低人的工時，可自動運作24小時，而可提升生產效率並降低生產成本。The flow method of the present invention separates a mixture containing solids and liquids such as slurry into solids and liquids through centrifugal separation, and the solids and liquids can be recovered respectively. The flow method of the present invention can exert excellent mixing and diffusion efficiency, and even the crystallization step can be performed more efficiently. The flow method of the present invention can reduce human working hours and can operate automatically for 24 hours, thereby improving production efficiency and reducing production costs.
(2)分散體回收步驟 本發明之流動法宜包含下述步驟：在前述(1)分離步驟(固液分離步驟)後，混合已沉澱之固體與該固體之不良溶劑而調製分散體，並回收該分散體(分散體回收步驟)。 (2) Dispersion recovery step The flow method of the present invention preferably includes the following steps: after the aforementioned (1) separation step (solid-liquid separation step), mixing the precipitated solid and the poor solvent of the solid to prepare a dispersion, and recovering the dispersion (dispersion recycling steps).
分散體回收步驟中，使用對於已沉澱之固體而言的不良溶劑來清洗已沉澱的固體，以作成包含固體與不良溶劑之分散體，回收良好沉澱的固體。In the dispersion recovery step, a poor solvent for the precipitated solid is used to clean the precipitated solid to prepare a dispersion containing the solid and the poor solvent, and the well-precipitated solid is recovered.
(3)溶劑取代步驟 本發明之流動法宜包含下述步驟：在前述(1)分離步驟(固液分離步驟)後，連續供給溶劑而將溶劑取代(溶劑取代步驟)。 (3) Solvent substitution step The flow method of the present invention preferably includes the following step: after the aforementioned (1) separation step (solid-liquid separation step), a solvent is continuously supplied to replace the solvent (solvent substitution step).
亦可用溶劑洗淨因離心分離而沉澱之固體。使用溶劑對已沉澱之固體進行溶劑取代，接著便可由此獲得已沉澱之固體。Solvents can also be used to clean the solids precipitated by centrifugation. The precipitated solid can then be obtained by solvent substitution using a solvent.
亦可於溶劑取代步驟之後設有以下步驟：混合已沉澱之固體與該固體之不良溶劑而調製成分散體，並回收該分散體(分散體回收步驟)。The following step may also be provided after the solvent replacement step: mixing the precipitated solid and the poor solvent of the solid to prepare a dispersion, and recovering the dispersion (dispersion recovery step).
溶劑取代步驟之後、或者分散體回收步驟之後，藉由離心分離進行固液分離而取出固體並回收。After the solvent substitution step or the dispersion recovery step, solid-liquid separation is performed by centrifugal separation, and the solid is taken out and recovered.
藉由對漿料等包含固體及液體之混合物進行溶劑取代，可藉由後續步驟使漿料中之固體晶析或乾燥。By performing solvent substitution on a mixture containing solids and liquids such as slurry, the solids in the slurry can be crystallized or dried through subsequent steps.
(4)流動裝置 本發明包含一種流動裝置，其具備分離機構，該分離機構係藉由離心分離將包含固體及液體之混合物分離成固體及液體，前述分離機構中，係連續供給包含固體及液體之混合物，並回收上清液而使固體沉澱。 (4)Mobile device The present invention includes a flow device equipped with a separation mechanism that separates a mixture containing solids and liquids into solids and liquids through centrifugal separation. In the separation mechanism, the mixture containing solids and liquids is continuously supplied and recovered. supernatant to precipitate the solid.
本發明包含一種流動裝置，其具備分離機構，該分離機構係藉由離心分離將包含固體及液體之混合物分離成固體及液體，前述分離機構中，係連續供給溶解有固體之溶液與該固體之不良溶劑，調製包含已晶析之固體及液體之混合物，並回收上清液而使固體沉澱。The present invention includes a flow device equipped with a separation mechanism that separates a mixture containing solids and liquids into solids and liquids by centrifugal separation. The separation mechanism continuously supplies a solution containing a solid and a mixture of the solids. A poor solvent is used to prepare a mixture containing crystallized solids and liquids, and recover the supernatant to precipitate the solids.
流動裝置中之分離機構係採用前述之(1)固液分離步驟。The separation mechanism in the flow device adopts the aforementioned (1) solid-liquid separation step.
[2]流動合成法及流動合成裝置 (1)流動合成法 本發明包含一種流動合成法，其於前述流動法中的前述分離步驟之前步驟或後步驟，包含固液反應步驟、氣液反應步驟、液液反應步驟、固固反應步驟等反應步驟。 [2]Flow synthesis method and flow synthesis device (1)Flow synthesis method The present invention includes a flow synthesis method, which includes solid-liquid reaction steps, gas-liquid reaction steps, liquid-liquid reaction steps, solid-solid reaction steps and other reaction steps before or after the separation step in the flow method.
本發明之流動合成法中，可應用一般的合成法。In the flow synthesis method of the present invention, general synthesis methods can be applied.
本發明之流動合成法中，針對固體狀化合物，可將液體狀化合物在反應會進行的溫度範圍內、並在固液接觸界面(固液界面)進行固液反應，藉此合成目標化合物。In the flow synthesis method of the present invention, for solid compounds, the target compound can be synthesized by subjecting the liquid compound to a solid-liquid reaction within the temperature range where the reaction will proceed and at the solid-liquid contact interface (solid-liquid interface).
本發明之流動合成法中，針對氣體狀化合物，可將液體狀化合物在反應會進行的溫度範圍內、並在氣液接觸界面(氣液界面)進行氣液反應，藉此合成目標化合物。In the flow synthesis method of the present invention, for gaseous compounds, the target compound can be synthesized by subjecting the liquid compound to a gas-liquid reaction within the temperature range in which the reaction proceeds and at the gas-liquid contact interface (gas-liquid interface).
本發明之流動合成法中，針對液體狀化合物，可將液體狀化合物在反應會進行的溫度範圍內進行液液反應，藉此合成目標化合物。In the flow synthesis method of the present invention, the target compound can be synthesized by subjecting the liquid compound to a liquid-liquid reaction within a temperature range in which the reaction proceeds.
本發明之流動合成法中，可不使用溶劑，而對於固體狀化合物，便可將固體狀化合物在反應會進行的溫度範圍內緩緩地接觸，同時在固體接觸之界面(固固界面)進行固固反應，藉此合成目標化合物。In the flow synthesis method of the present invention, a solvent does not need to be used. For solid compounds, the solid compounds can be slowly brought into contact within the temperature range where the reaction will proceed, and at the same time, the solid compounds are solidified at the interface of solid contact (solid-solid interface). solid reaction to synthesize the target compound.
(2)流動合成裝置 本發明包含一種流動合成裝置，其於前述流動裝置的前述分離機構之前機構或後機構，具備固液反應機構、氣液反應機構、液液反應機構、固固反應機構等反應機構。 (2)Flow synthesis device The present invention includes a flow synthesis device, which is equipped with reaction mechanisms such as a solid-liquid reaction mechanism, a gas-liquid reaction mechanism, a liquid-liquid reaction mechanism, and a solid-solid reaction mechanism before or after the separation mechanism of the flow device.
流動合成裝置中之反應機構係採用前述(1)流動合成法。The reaction mechanism in the flow synthesis device adopts the aforementioned (1) flow synthesis method.
[3]藉由離心分離所進行之流動法的具體態樣 首先，在茄型燒瓶等容器中混合硫酸鎂等固體與甲醇等液體，使用攪拌器進行攪拌，調製包含固體及液體之混合物(漿料)。 [3] Specific aspects of flow method by centrifugal separation First, a solid such as magnesium sulfate and a liquid such as methanol are mixed in a container such as an eggplant-shaped flask, and stirred using a stirrer to prepare a mixture (slurry) containing the solid and the liquid.
接下來，使用泵將包含固體及液體之混合物輸送至固液分離裝置(具備離心分離機之裝置)。Next, a pump is used to transport the mixture containing solids and liquids to a solid-liquid separation device (a device equipped with a centrifugal separator).
接下來，使用馬達使固液分離裝置之旋轉體(離心分離機)旋轉，從固液分離裝置之吐出部回收上清液。Next, a motor is used to rotate the rotating body (centrifuge) of the solid-liquid separation device, and the supernatant liquid is collected from the discharge part of the solid-liquid separation device.
又，在固液分離裝置之旋轉體中，回收因離心力而沉澱之固體。In addition, in the rotating body of the solid-liquid separation device, solids precipitated by centrifugal force are recovered.
[實施例] 以下展示實施例具體說明本發明之流動法。 [Example] The following examples are shown to specifically illustrate the flow method of the present invention.
惟本發明不受實施例所限定。However, the present invention is not limited by the examples.
以離心分離所進行之流動法的實施 首先，在100mL茄型燒瓶中混合500mg硫酸鎂(固體)與30mL甲醇(液體)，使用攪拌器進行攪拌，調製包含硫酸鎂與甲醇之混合物(漿料)。 Implementation of flow method by centrifugal separation First, 500 mg of magnesium sulfate (solid) and 30 mL of methanol (liquid) were mixed in a 100 mL eggplant-shaped flask, and stirred using a stirrer to prepare a mixture (slurry) containing magnesium sulfate and methanol.
接下來，使用泵將漿料(硫酸鎂之甲醇溶液)以流速3mL／min輸送至固液分離裝置(具備離心分離機之裝置)。Next, the slurry (methanol solution of magnesium sulfate) was transported to a solid-liquid separation device (a device equipped with a centrifugal separator) at a flow rate of 3 mL/min using a pump.
接下來，使用馬達使固液分離裝置之旋轉體(離心分離機)旋轉。Next, a motor is used to rotate the rotating body (centrifuge) of the solid-liquid separation device.
之後，從固液分離裝置之吐出部回收上清的甲醇(液體)。Thereafter, the supernatant methanol (liquid) is recovered from the discharge part of the solid-liquid separation device.
又，在固液分離裝置之旋轉體中，回收因離心力而沉澱之硫酸鎂(固體)。In addition, magnesium sulfate (solid) precipitated by centrifugal force is recovered in the rotating body of the solid-liquid separation device.
[產業上之可利用性] 本發明之流動法在連續生產中，可使晶析步驟、過濾步驟等精製步驟亦與合成步驟相同地連續化，藉此，從合成步驟至精製步驟就能連續生產。 [Industrial availability] In continuous production, the flow method of the present invention can make the purification steps such as the crystallization step and the filtration step also be continuous in the same manner as the synthesis step, thereby enabling continuous production from the synthesis step to the purification step.
本發明之流動法藉由離心分離將包含固體及液體之混合物分離成固體及液體，可分別回收固體及液體，又，利用流動合成法之優異擴散效率，還可更有效率地進行晶析步驟。The flow method of the present invention separates a mixture containing solids and liquids into solids and liquids through centrifugal separation. The solids and liquids can be recovered respectively. Furthermore, by utilizing the excellent diffusion efficiency of the flow synthesis method, the crystallization step can be performed more efficiently. .
藉由採用本發明之流動法，可降低人的工時，而且流動法亦可自動運作24小時，而可提升生產效率並降低生產成本。By adopting the flow method of the present invention, human working hours can be reduced, and the flow method can also be automatically operated for 24 hours, thereby improving production efficiency and reducing production costs.
Claims (8)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022-098629 | 2022-06-20 | ||
| JP2022098629 | 2022-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202405401A true TW202405401A (en) | 2024-02-01 |
Family
ID=89379997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW112122804A TW202405401A (en) | 2022-06-20 | 2023-06-17 | flow method |
Country Status (2)
| Country | Link |
|---|---|
| TW (1) | TW202405401A (en) |
| WO (1) | WO2023248965A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004223451A (en) * | 2003-01-24 | 2004-08-12 | Sankio Chemical Co Ltd | Separating/refining method and separating/refining apparatus for organic compound |
-
2023
- 2023-06-17 TW TW112122804A patent/TW202405401A/en unknown
- 2023-06-19 WO PCT/JP2023/022522 patent/WO2023248965A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023248965A1 (en) | 2023-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101283843B1 (en) | Purification method of lithium carbonate | |
| CN105905930A (en) | Method for preparing sodium aluminate solution purifying filter aid and utilizing filter cake in alumina production | |
| EP0297998B1 (en) | Process for extracting and purifying gallium from bayer liquors | |
| EP0124213A1 (en) | Extraction process | |
| CN109437116B (en) | Device and method for extracting sulfur from sulfur-containing waste residues | |
| CN102897804A (en) | Method for preparing lithium carbonate directly from lithium chloride and carbon dioxide | |
| CN108977222B (en) | Separation system and separation method for direct coal liquefaction oil residue | |
| TW202405401A (en) | flow method | |
| JP2557578B2 (en) | Method for recovering liquid phase oxidation catalyst for paraxylene | |
| CN105671324A (en) | Method for preparing ammonium rhenate from rhenium-enriched slags | |
| US2224814A (en) | Electrolytic production of metals | |
| CA2544316A1 (en) | Method of separating and recovering acid/sugar solution and lignophenol derivative from lignocellulosic material | |
| CN110387279B (en) | Recovery method of hydrophilic ionic liquid for removing sulfur in coal | |
| TWI490173B (en) | Method for recovering waste silicon waste from cutting oil | |
| TW202405402A (en) | flow method | |
| EP0230686B1 (en) | Process for preparing an aqueous solution of sodium chloride, and process for producing sodium bicarbonate | |
| CN110306040B (en) | Liquid-solid three-phase back extraction system and treatment method and application thereof | |
| EP1307400B1 (en) | Method for producing phosphoric acid | |
| CN109368594A (en) | The recovery method of iodine in a kind of cephalosporins medicine waste liquid | |
| CN113200560B (en) | Process method for circularly preparing nano calcium carbonate | |
| RU2321538C2 (en) | Method of separation of silicon powder fluoride salts of alkaline metals and plant for realization of this method | |
| CN114524569B (en) | Wastewater treatment device and process for polyorganosiloxane microsphere production | |
| JP2008208087A (en) | Method for producing norbornene derivative | |
| US20190062870A1 (en) | Solubilization of scandium from fluoride bearing materials | |
| RU2226226C1 (en) | Nickel/cobalt concentrate processing method |