TW202402295A - 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法 - Google Patents

治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法 Download PDF

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Publication number
TW202402295A
TW202402295A TW112113060A TW112113060A TW202402295A TW 202402295 A TW202402295 A TW 202402295A TW 112113060 A TW112113060 A TW 112113060A TW 112113060 A TW112113060 A TW 112113060A TW 202402295 A TW202402295 A TW 202402295A
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TW
Taiwan
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substituted
unsubstituted
cgvhd
patient
inhibitor
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TW112113060A
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English (en)
Chinese (zh)
Inventor
布魯斯 R 布雷札
萊恩 富林
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美商製藥公司
美國明尼蘇達大學評議委員會
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Publication of TW202402295A publication Critical patent/TW202402295A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
TW112113060A 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法 TW202402295A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361910944P 2013-12-02 2013-12-02
US61/910,944 2013-12-02
US201461973178P 2014-03-31 2014-03-31
US61/973,178 2014-03-31

Publications (1)

Publication Number Publication Date
TW202402295A true TW202402295A (zh) 2024-01-16

Family

ID=53270044

Family Applications (3)

Application Number Title Priority Date Filing Date
TW112113060A TW202402295A (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
TW103141826A TWI743019B (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
TW110135203A TW202228700A (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW103141826A TWI743019B (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法
TW110135203A TW202228700A (zh) 2013-12-02 2014-12-02 治療及預防異體抗體所驅動之慢性移植體對抗宿主疾病之方法

Country Status (14)

Country Link
US (6) US20150157634A1 (https=)
EP (1) EP3076975A4 (https=)
JP (5) JP2017501140A (https=)
KR (2) KR20230104754A9 (https=)
CN (2) CN110478353B (https=)
AU (4) AU2014360758B2 (https=)
BR (1) BR112016012158A2 (https=)
CA (2) CA2932255C (https=)
EA (1) EA201691020A1 (https=)
IL (4) IL292522A (https=)
MX (2) MX389020B (https=)
PH (2) PH12020552048A1 (https=)
TW (3) TW202402295A (https=)
WO (1) WO2015084857A1 (https=)

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JO3754B1 (ar) 2012-06-04 2021-01-31 Pharmacyclics Llc أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
US9795604B2 (en) * 2013-10-25 2017-10-24 Pharmacyclics Llc Methods of treating and preventing graft versus host disease
AR102871A1 (es) 2014-12-03 2017-03-29 Pharmacyclics Llc Métodos de tratamiento de fibrosis
US20190070145A1 (en) 2016-03-22 2019-03-07 Mayo Foundation For Medical Education And Research Using fatty acid synthase inhibitors to treat fibrosis
WO2018002958A1 (en) * 2016-06-30 2018-01-04 Sun Pharma Advanced Research Company Limited Novel hydrazide containing compounds as btk inhibitors
WO2018075888A1 (en) * 2016-10-21 2018-04-26 Regents Of The University Of Minnesota Materials and methods for treating or preventing graft-versus-host-disease
CZ2017787A3 (cs) 2017-12-08 2019-06-19 Zentiva, K.S. Farmaceutické kompozice obsahující ibrutinib
WO2021038540A1 (en) 2019-08-31 2021-03-04 Sun Pharma Advanced Research Company Limited Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
US12496303B2 (en) 2020-10-19 2025-12-16 Washington University Conditioning agents for use in allogeneic hematopoietic stem cell transplantation
US20240025990A1 (en) * 2020-12-01 2024-01-25 City Of Hope Prevention and treatment of graft-versus-host disease (gvhd)
WO2022161484A1 (en) * 2021-01-30 2022-08-04 Beigene, Ltd. Methods of treating chronic active antibody-mediated rejection using btk inhibitors
US20240287781A1 (en) 2023-02-28 2024-08-29 Toto Ltd. Wall-mounted flush toilet

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US6326469B1 (en) 1994-04-22 2001-12-04 Sugen, Inc. Megakaryocytic protein tyrosine kinases
US20060182723A1 (en) * 2005-01-25 2006-08-17 Spellberg Brad J Methods for treating refractory infections in neutropenic individuals
KR20080098490A (ko) * 2006-01-13 2008-11-10 파마시클릭스, 인코포레이티드 티로신 키나제 억제제 및 이의 용도
BRPI0622054B8 (pt) 2006-09-22 2021-05-25 Oxford Amherst Llc composto e composição farmacêutica
ES2660418T3 (es) * 2008-07-16 2018-03-22 Pharmacyclics Llc Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos
EP2424368B1 (en) * 2009-04-29 2014-12-31 Locus Pharmaceuticals, Inc. Pyrrolotriazine compounds
WO2011026122A2 (en) * 2009-08-31 2011-03-03 Amplimmune, Inc. B7-h4 fusion proteins and methods of use thereof
US20120071497A1 (en) * 2010-06-03 2012-03-22 Pharmacyclics, Inc. Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
CN107898791A (zh) * 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
KR20140058543A (ko) * 2011-07-08 2014-05-14 노파르티스 아게 신규 피롤로 피리미딘 유도체
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US10722577B2 (en) * 2012-05-25 2020-07-28 Sloan Kettering Institute For Cancer Research Methods for treating GI syndrome and graft versus host disease
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IL315294A (en) * 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of bruton's tyrosine kinase inhibitor

Also Published As

Publication number Publication date
CN105939717A (zh) 2016-09-14
IL245715A0 (en) 2016-07-31
KR20230104754A (ko) 2023-07-10
JP2024072291A (ja) 2024-05-27
AU2020204276A1 (en) 2020-07-16
JP2025118595A (ja) 2025-08-13
US20250381188A1 (en) 2025-12-18
AU2024278490A1 (en) 2025-01-09
US20180078558A1 (en) 2018-03-22
AU2014360758A1 (en) 2016-06-16
IL315228A (en) 2024-10-01
JP2020105181A (ja) 2020-07-09
CN110478353B (zh) 2022-12-30
EP3076975A1 (en) 2016-10-12
US20230100137A1 (en) 2023-03-30
CN110478353A (zh) 2019-11-22
CA3210338A1 (en) 2015-06-11
WO2015084857A1 (en) 2015-06-11
IL276683A (en) 2020-09-30
EA201691020A1 (ru) 2017-01-30
KR20160085817A (ko) 2016-07-18
AU2014360758B2 (en) 2020-03-26
BR112016012158A2 (pt) 2017-09-26
PH12020552048A1 (en) 2022-05-11
US20150157634A1 (en) 2015-06-11
IL292522A (en) 2022-06-01
AU2022203810B2 (en) 2024-10-03
US20210177854A1 (en) 2021-06-17
MX2022000209A (es) 2022-02-03
CN105939717B (zh) 2019-09-13
TW201605454A (zh) 2016-02-16
TW202228700A (zh) 2022-08-01
MX2016006955A (es) 2016-09-07
CA2932255A1 (en) 2015-06-11
EP3076975A4 (en) 2017-05-03
AU2022203810A1 (en) 2022-06-23
JP2023029899A (ja) 2023-03-07
MX389020B (es) 2025-03-20
TWI743019B (zh) 2021-10-21
US20240293409A1 (en) 2024-09-05
PH12016501051A1 (en) 2016-08-15
JP2017501140A (ja) 2017-01-12
KR20230104754A9 (ko) 2024-11-15
CA2932255C (en) 2023-10-10

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