TW202344242A - Compositions and related methods for skin lightening - Google Patents

Abstract

A composition for skin lightening, a method of forming the composition, and a method of skin lightening. The composition includes at least one skin care or dermatologically acceptable additive and an antioxidant, and the antioxidant includes at least two selected from the group consisting of: Bakuchiol, Vitamin C , Idebenone, coenzyme Q10, vitamin E, ferulic acid, resveratrol, ergothioneine, ellagic acid ( Ellagic acid), Glutathione, Azelaic acid, hydroxyphenoxypropionic acid ((R)-2-(4-hydroxyphenoxy) propionic acid [(R)-HPOPA]), light Glycyrrhizin (Glabridin), tetrahydrocurcumin (Tetrahydrocurcumin; THC), and combinations thereof, the composition further comprises at least an inflammation inhibitor, a melanin production inhibitor, a stratum corneum metabolizer and an absorption enhancer.

Description

Compositions and related methods for skin whitening

The present invention relates to the technical field of skin care, and in particular, to a composition for skin whitening that can effectively reduce the production of melanin to achieve whitening and lightening effects, a method of forming the composition, and a method of skin whitening.

The formation of melanin in human skin originates from melanocytes concentrated at the bottom of the epidermis. When the skin is exposed to ultraviolet rays, or is affected by emotions, stress or endocrine, keratinocytes will release free radicals. Free radicals are metabolized by the body in maintaining physiological functions. It is an unstable substance that is extremely active and will actively undergo a series of redox reactions with substances in the cortex, further stimulating peripheral nerves to release interleukin, prostaglandin and other cytokines, causing an inflammatory reaction. And prompts the pituitary gland to secrete α-melanocyte-stimulating hormon (α-MSH). α-MSH activates tyrosinase in melanocytes. The activated tyrosinase reacts with "tyrosine" in the blood and is oxidized to produce "dopa" which is oxidized again and becomes "dopa". Dopaquinone" releases melanin and melanoidin; at this time, melanosomes containing a large amount of melanin transfer melanin to surrounding keratinocytes through the synapses of melanocytes to protect skin cells. The melanin that is released next will be gradually sent to the epidermis, and then gradually moves to the epidermis to darken the skin, and is eventually metabolized. Therefore, reducing the stimulation of active free radicals, inhibiting the effects of peripheral nerves, slowing down the inflammatory reactions caused by interleukins, prostaglandins, etc., or inhibiting tyrosinase activity are considered key steps to reduce melanin production (whitening). Therefore, how to solve the above-mentioned conventional problems and deficiencies is the direction that relevant manufacturers in this industry are eager to study and improve.

Therefore, in order to effectively solve the above problems, the main purpose of the present invention is to provide a composition for skin whitening with whitening and lightening effects, a method of forming the composition, and a method of skin whitening. The secondary purpose of the present invention is to provide a composition for skin whitening with antioxidant effect, a method of forming the composition, and a method of skin whitening. A secondary objective of the present invention is to provide a composition for skin whitening that can effectively reduce melanin production, a method for forming the composition, and a method for skin whitening. In order to achieve the above object, the present invention provides a composition for skin whitening, which includes at least one skin care product or dermatologically acceptable additive, an antioxidant, at least one inflammation inhibitor, and a melanin production inhibitor. A stratum corneum metabolism agent and an absorption enhancer, the antioxidant comprising two groups selected from the following: Bakuchiol, Vitamin C, Idebenone, coenzyme Q10 (coenzyme Q10), vitamin E (Vitamin E), ferulic acid (ferulic acid), resveratrol (resveratrol), ergothioneine (Ergothioneine), ellagic acid (Ellagic acid), glutathione ( Glutathione), Azelaic acid, (R) -2- (4-hydroxyphenoxy) propionic acid [(R)-HPOPA]), Glabridin, Tetrahydroturmeric Tetrahydrocurcumin (THC), and combinations thereof. In one embodiment, the inflammation inhibitor is selected from any one of steroids, chamomile oil, bisabolol, panthothenic acid or a combination thereof, and the melanin The production inhibitor is selected from any one of vitamin B3 (nicotinic acid), hydroxyphenoxypropionic acid ((R)-2-(4-hydroxyphenoxy) propionic acid [(R)-HPOPA]) or a combination thereof, as described The stratum corneum metabolizing agent is selected from the group consisting of Vitamin A, Glycolic Acid, Lactic Acid, Salicylic acid, Mandelic Acid, and Azelaic acid. ), vitamin B5 (Panthothenic Acid) or any combination thereof, the absorption enhancer is selected from ethanol, propylene glycol, ethoxydiglycol, isosorbide dimethyl Ether (Isosorbide Dimethyl Ether), azone (Azone) any one or a combination thereof. In one embodiment, the skin care product or dermatologically acceptable additive is selected from the group consisting of: water, glycerin, wax, alcohol, vegetable oil, mineral oil, silicone, fatty ester, fatty alcohol , ethylene glycol, polyethylene glycol, and combinations thereof. In one embodiment, the composition includes 0.01 to 0.03 weight percent ergothioneine, 0.01 to 3 weight percent tetrahydrocurcumin, 1 to 3 weight percent vitamin B3, and 1 to 3 weight percent vitamin B3. B5 and 2 to 5 weight percent ethoxyethylene glycol. In one embodiment, it is further defined as a topical composition for application to human skin. In one embodiment, the external composition is in the form of a gel, an emulsion, an oil-in-water emulsion, a water-in-oil emulsion, a foam, a liquid, a mousse, a powder, a solid, or an ointment suitable for external application to human skin. In order to achieve the above object, the present invention provides a method for forming the composition, which method includes: Provide at least one skin care or dermatologically acceptable additive; Provide an antioxidant, at least one inflammation inhibitor, at least one melanin production inhibitor, at least one stratum corneum metabolizing agent, and at least one absorption enhancer; and The composition is combined with the skin care product or dermatologically acceptable additives and the antioxidant, inflammation inhibitor, melanin production inhibitor, stratum corneum metabolism agent, and absorption enhancer. In order to achieve the above object, the present invention provides the use of the composition in preparing a skin whitening external composition for a subject, and the use includes: providing the topical composition; and The topical composition is applied to the subject's skin. In one embodiment, the topical composition is applied to the skin at least once daily for a period of one week or more. In one embodiment, the patient suffers from one or more of the following: dark skin, pigmented skin discoloration, pigmented birthmark, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, freckles, age spots, liver spots, sun exposure Injuries, suntans, pigmented acne marks, scars, dark spots, chloasma, post-burn scars, yellowing of the skin or dark circles. Through various specific embodiments of the present invention, the beneficial effects of the present invention are: the composition of the present invention, ergothioneine, tetrahydrocurcumin, vitamin B3, vitamin B5 and ethoxyethylene glycol, has a synergistic effect , the prepared composition has strong DPPH scavenging ability, total reducing power, inhibits inflammation, inhibits the transfer of melanosomes, inhibits tyrosinase activity, thereby significantly reducing melanin production. In addition, the composition contains the ability to accelerate keratinization It is a raw material that has layer metabolism effect and is supplemented by the penetration effect of the skin stratum corneum. This can achieve the antioxidant whitening effect and can be used to prepare antioxidant whitening skin care products.

The above objects and structural and functional characteristics of the present invention will be explained based on the preferred embodiments of the accompanying drawings. In the following, with regard to the composition and technical content of the composition for skin whitening, the method of forming the composition, and the skin whitening method of the present invention, various applicable examples are enumerated with reference to the accompanying drawings. Detailed description; however, the present invention is of course not limited to the enumerated embodiments, drawings or detailed descriptions. Furthermore, those familiar with this technology should also understand that the enumerated embodiments and attached drawings are only for reference and illustration, and are not intended to limit the present invention; it can be easily implemented based on these descriptions. Inventions completed by modifications or changes are deemed to be within the scope of the spirit and intention of the present invention. Of course, such inventions are also included in the patentable scope of the present invention. In addition, the directional terms mentioned in the following embodiments, such as "up", "down", "left", "right", "front", "back", etc., are only for reference to the directions shown in the attached figures. Therefore, the directional terms used are used to illustrate but not to limit the present invention; furthermore, in the following embodiments, the same or similar component numbers will be used for the same or similar components. A composition for skin whitening, including at least one skin care or dermatologically acceptable additive, an antioxidant, at least one inflammation inhibitor, a melanin production inhibitor, a cuticle metabolism agent and an absorption promoter agent. The skin care products or dermatologically acceptable additives include but are not limited to: fragrances; preservatives; alcohols (such as ethanol, propanol and benzyl alcohol); glycerin; adhesives; flow agents; triacetin; vegetable oils (such as hydrogenated vegetable oil); mineral oil; water; silicones (such as silicone oil); silicon dioxide; waxes (such as carnauba wax and beeswax); fatty esters and fatty alcohols; ethylene glycols and polyethylene glycols; and combinations thereof. Further stated, the composition may contain one or more additional ingredients. Suitable additives include those known in the present invention, including but not limited to humectants, emollients, emulsifiers, surfactants, oils, extractants, etc. agents, skin protectants, disinfectants, preservatives, anti-neuralgia compounds, antioxidants, exfoliants, fragrances, pigments, fillers, solvents, vehicles, carriers, and other types known to those of ordinary skill in the art. Additives, and combinations thereof, which may be used alone or in combination, and in particular optional additives of any type used in personal care products and cosmetics, are included. The antioxidant is used to refer to compounds, plant extracts or material combinations with the function of scavenging free radicals, which include a group selected from the following two: Bakuchiol, Vitamin C , Idebenone, coenzyme Q10, vitamin E, ferulic acid, resveratrol, ergothioneine, ellagic acid ( Ellagic acid), glutathione (Glutathione), azelaic acid (Azelaic acid), hydroxyphenoxypropionic acid ((R) -2- (4-hydroxyphenoxy) propionic acid [(R)-HPOPA]), light Glabridin, Tetrahydrocurcumin (THC), and combinations thereof. The inflammation inhibitor is selected from any one of steroids, chamomile oil, bisabolol, vitamin B5 (Panthothenic Acid) or a combination thereof. The melanin production inhibitor is selected from any one of vitamin B3 (nicotinic acid), hydroxyphenoxypropionic acid ((R)-2-(4-hydroxyphenoxy) propionic acid [(R)-HPOPA]) or a combination thereof. The stratum corneum metabolizing agent is selected from the group consisting of Vitamin A, Glycolic Acid, Lactic Acid, Salicylic acid, Mandelic Acid, and Azelaic acid. acid), vitamin B5 (Panthothenic Acid) any one or a combination thereof. The absorption accelerator is selected from any one of ethanol, propylene glycol, ethoxydiglycol, Isosorbide Dimethyl Ether, Azone or its combination. In the best embodiment of the present invention, the optimal composition of the composition includes 0.01 to 0.03 weight percent (%wt.) of ergothioneine, 0.01 to 3 weight percent of tetrahydrocurcumin, 1 to 3 weight percent percentage of vitamin B3, 1 to 3 weight percent of vitamin B5, and 2 to 5 weight percent of ethoxyethylene glycol. In other words, in the present invention, the composition of the best embodiment has five ingredients, Moreover, each component has a different effect respectively, and these five components form the composition to form the best implementation of the present invention. In various embodiments, the composition is applied externally to the skin of a subject. The subject is usually human and can include men and women of various ages. It should be noted that the method/ The compositions are not limited to particular subjects. The compositions may take a variety of forms, including solids, gels, and liquids. For example, the composition may be formulated as a gel, emulsion, lotion, ointment, mousse, powder, or foam for application to the skin of a subject. In another example, the composition may be formulated by spraying onto the skin of a subject. Additionally, the compositions may be formulated as a spray, such as an aerosol spray or a pump spray. In yet another example, the composition can also be formulated for application using pre-moistened wipes. In another example, the composition can be formulated as a solid that is rubbed on a subject's skin, similar to commercially available scrub products. Please refer to Figure 1, which shows the preparation method of the composition of the present invention. First, at least one skin care product or dermatologically acceptable additive is provided (the ingredients of the additive are detailed as described in paragraph 25), and then an antioxidant is provided. , inflammation inhibitor, melanin production inhibitor, stratum corneum metabolism agent and absorption enhancer, a total of five raw materials with different functions. Finally, the aforementioned additives and various raw materials are mixed evenly according to the proportion to obtain the composition of the present invention. It should be noted that if Tetrahydrocurcumin (THC) among the antioxidants is selected as one of the antioxidants in the composition, the Tetrahydrocurcumin must be added after all the raw materials are mixed. Next, the use of the composition of the present invention in preparing a skin whitening topical composition for a subject is further described. The use includes providing the topical composition and applying the topical composition to the skin of the subject. , to further illustrate, the composition can be used to whiten the skin of a subject. As mentioned above, the subject is usually a human and can include men and women of different ages. The composition is not limited to a specific subject or subject. The location of the skin on the subject. For example, an individual may apply the composition to their face, neck, arms, hands, chest, torso, legs, feet, etc., or any combination thereof, depending on the need for use. The composition may be applied to areas of the skin that may be hyperpigmented or hypopigmented. , for example, the subject's skin is inherently dark, pigmented skin discoloration, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, freckles, age spots, liver spots, sun damage, tanning, pigmented Problems such as acne marks, scars, dark spots, melasma, post-burn scars, yellowing of the skin or dark circles. In addition, the composition can be applied daily or several times a day according to the needs of the subject. In the methods of the invention, the frequency of application (eg, topical application) can depend on several factors, including the degree of skin whitening desired by the subject. . Generally, the frequency of application is once or twice daily, in the morning and/or evening. Please refer to Figure 2, which is a statistical chart of the DPPH clearance results of the composition of the present invention compared with conventional ingredients (glutathione and coenzyme Q10). DPPH (1,1-diphenyl-2-picrylhydrazyl) is a stable Free radicals, when dissolved in methanol or ethanol, will appear blue-violet. When the added component sample can react directly with DPPH free radicals, it will block the chain reaction of DPPH free radicals. At this time, the color of the DPPH solution will appear blue-violet. It will turn into a clear yellow, which means that the added component sample has the ability to capture DPPH free radicals. The lighter the color, the stronger the ability to capture DPPH free radicals, which means the antioxidant ability of this component sample. The better, therefore, as can be seen from the figure, the composition has a fairly strong ability to capture DPPH free radicals. Please refer to Figure 3, which is a statistical chart of the whitening effect after the subjects continued to use the composition. This example provides ten subjects to use the composition twice a day for 56 days, and then use skin testing. The instrument measured the whitening effect on the cheek area of the subject on the 0th day and the 56th day of use. As shown in the figure, it is obvious that the composition can indeed achieve the whitening effect. To sum up, the present invention has the following advantages compared with the conventional ones: 1. It has the effect of whitening and lightening spots; 2. Has antioxidant effect; 3. Effectively reduce melanin production. The present invention has been described in detail above. However, the above description is only one of the preferred embodiments of the present invention and cannot limit the scope of the present invention. That is to say, all equivalent changes and modifications made according to the application scope of the present invention should still fall within the scope of the patent of the present invention.

S1～S3: steps

Figure 1 is a flow chart of the preparation steps of the composition of the present invention; Figure 2 is a statistical graph showing the DPPH clearance results of the composition of the present invention compared with conventional ingredients; Figure 3 is a statistical graph of the whitening effect after the subjects continued to use the composition.

S1~S3: steps

Claims (10)

A composition for skin whitening, which includes: At least one skin care product or dermatologically acceptable additive; An antioxidant, comprising at least two antioxidants, the antioxidants being selected from the group consisting of: Bakuchiol, Vitamin C, Idebenone, Coenzyme Q10 ( coenzyme Q10), vitamin E, ferulic acid, resveratrol, ergothioneine, ellagic acid, glutathione , Azelaic acid, (R) -2- (4-hydroxyphenoxy) propionic acid [(R)-HPOPA]), Glabridin, tetrahydrocurcumin ( Tetrahydrocurcumin; THC), and combinations thereof; at least one inflammation inhibitor; at least one melanin production inhibitor; at least one stratum corneum metabolizing agent; and At least one absorption enhancer. The composition according to claim 1, wherein the inflammation inhibitor is selected from any one of steroids (steroids), chamomile oil (Chamomile Oil), bisabolol (Bisabolol), vitamin B5 (Panthothenic Acid) or any other thereof Combination, the melanin production inhibitor is selected from any one of vitamin B3 (nicotinic acid), hydroxyphenoxypropionic acid ((R)-2-(4-hydroxyphenoxy) propionic acid [(R)-HPOPA]) or In combination thereof, the stratum corneum metabolizing agent is selected from the group consisting of Vitamin A, Glycolic Acid, Lactic Acid, Salicylic acid, Mandelic Acid, and nonalcoholic acid. Azelaic acid, vitamin B5 (Panthothenic Acid) or any combination thereof, the absorption enhancer is selected from the group consisting of ethanol, propylene glycol, ethoxydiglycol, isopropyl Any one of Isosorbide Dimethyl Ether, Azone or a combination thereof. The composition of claim 1, wherein the skin care or dermatologically acceptable additive is selected from the group consisting of: water, glycerin, wax, alcohols, vegetable oil, mineral oil, silicone, Fatty esters, fatty alcohols, ethylene glycols, polyethylene glycols, and combinations thereof. The composition according to claim 2, wherein the composition includes 0.01 to 0.03 weight percent of ergothioneine, 0.01 to 3 weight percent of tetrahydrocurcumin, 1 to 3 weight percent of vitamin B3, 1 to 3 Weight percent vitamin B5 and 2 to 5 weight percent ethoxyethylene glycol. The composition according to claim 1 is further defined as an external composition for application to human skin. The composition of claim 5, wherein the external composition is in the form of a gel, an emulsion, an oil-in-water emulsion, a water-in-oil emulsion, a foam, a liquid, a mousse, or a powder , a solid, or an ointment suitable for external application to human skin. A method of forming a composition as described in claim 1, the method comprising: Provide at least one skin care or dermatologically acceptable additive; Provide an antioxidant, at least one inflammation inhibitor, at least one melanin production inhibitor, at least one stratum corneum metabolizing agent, and at least one absorption enhancer; and The composition is combined with the skin care product or dermatologically acceptable additives and the antioxidant, inflammation inhibitor, melanin production inhibitor, stratum corneum metabolism agent, and absorption enhancer. A method of using the composition of claim 1 to prepare a skin whitening external composition for a subject, which method includes: providing the topical composition; and The topical composition is applied to the subject's skin. The use as claimed in claim 8, wherein the external composition is applied to the skin at least once a day for a period of one week or more. Use as described in claim 8, in which the patient suffers from one or more of the following: dark skin, pigmented skin discoloration, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, freckles, age spots, liver spots , sun damage, tanning, pigmented acne marks, scars, dark spots, chloasma, post-burn scars, yellowing of the skin or dark circles.

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