TW202342486A - 可用於穩定苯丙胺酸羥化酶突變之化合物及方法 - Google Patents

可用於穩定苯丙胺酸羥化酶突變之化合物及方法 Download PDF

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TW202342486A
TW202342486A TW112107402A TW112107402A TW202342486A TW 202342486 A TW202342486 A TW 202342486A TW 112107402 A TW112107402 A TW 112107402A TW 112107402 A TW112107402 A TW 112107402A TW 202342486 A TW202342486 A TW 202342486A
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optionally substituted
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pyridin
pharmaceutically acceptable
acceptable salt
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帕司卡理司 露癸季雅 狄
海瑟 珍 芬立
珊卓拉 金
澤農 寇提提斯
布萊恩 Ｃ 舒克
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美商阿吉歐斯製藥公司
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Abstract

本揭露係關於式 I之化合物或其醫藥上可接受之鹽，其中m、R 1至R 5、R 5A、及L係在本文中定義。

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可用於穩定苯丙胺酸羥化酶突變之化合物及方法
相關申請案之交互參照
本申請案主張於2022年2月28日申請之美國臨時專利申請案第63/314,580號之優先權，其全部內容以引用方式併入本文中。
本申請案係關於穩定苯丙胺酸羥化酶(phenylalanine hydroxylase, PAH)突變之化合物、包含該等化合物之醫藥組成物、及使用該等化合物治療苯酮尿症之方法。
苯酮尿症(phenylketonuria, PKU)係影響全世界大約1:10,000人（在美國大約1:15,000至1:20,000）之體染色體隱性病症。全球患者數目取決於地區而有所變化。PKU發生在編碼苯丙胺酸羥化酶(PAH)之基因具有突變的患者中，PAH負責將苯丙胺酸轉化為酪胺酸。PAH係在肝臟中表現之四聚體酶，其活性需要BH4輔因子。PAH活性之降低或喪失導致血液及腦部中苯丙胺酸(Phe)之毒性累積。高水平的Phe會損傷腦白質並干擾神經傳導物質產生。若未治療，則高水平的Phe可導致兒童之智能障礙及IQ降低及成人之神經認知及精神問題，諸如執行功能缺陷（例如注意力、記憶力、靈活思考、及組織/時間管理方面的困難）、心理問題（例如憂鬱、焦慮、及情緒波動）、精神及/或行為問題（例如注意力不足過動症、自殘、思覺失調症、廣場恐怖症、及躁動）、及神經異常（例如痙攣、震顫、步態障礙、及癲癇）。
PKU表型可自輕度高苯丙胺酸血症(hyperphenylalaninemia, HPA)至導致未經治療之血液Phe濃度超過1200 µM之更嚴重表型變化。美國醫學指南目前建議將成人及未滿12歲兒童之血液Phe濃度維持在120至360 µM之範圍內。歐洲醫學指南目前建議將未滿12歲兒童及孕婦之血液Phe濃度維持低於360 µM，且將12歲以上非妊娠患者之血液Phe濃度維持低於600 µM。
用於治療PKU之標準照護係嚴格限制天然蛋白質攝入之Phe限制飲食。此類飲食係非常嚴格的飲食且難以堅持。目前有兩種藥物被核准用於治療PKU，該等藥物各具有其自身的挑戰。酷方(Kuvan)（二鹽酸沙丙蝶呤(sapropterin dihydrochloride)）係於2007年核准用於嬰兒至成人之合成BH4輔因子。酷方並非對所有PKU患者皆有效，且目前指南建議除非已知患者具有兩個無效突變，否則對患者進行反應測試。培伐利酶(pegvaliase)係一種酶替代療法，其於2018年核准用於血液Phe濃度大於600 µM之成人，儘管先前使用可用治療選項管理。培伐利酶一般涉及注射經純化之聚乙二醇化形式的苯丙胺酸解氨酶，該酶藉由將Phe轉化為氨及反式肉桂酸而非酪胺酸來還原Phe。由於所輸注之蛋白質之快速降解或去活化，酶替代療法之主要難題之一係在體內達到及維持蛋白質之治療有效量。目前克服此問題之方法係執行許多昂貴的高劑量注射。
所欲的是能夠使患者增加其天然蛋白質攝入之醫藥劑。
在一些態樣中，本揭露提供式 I之化合物： I或其醫藥上可接受之鹽，其中： m係1或2； R 1係 ； x係0至5； 各R a獨立地係鹵基、C 1-6烷基、C 3-6環烷基、C 1-6鹵烷基、C 1-6烷氧基、或C 1-6鹵烷氧基； R 2係C 1-4烷基、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、或可選地經取代之雜芳基； R 3係H或C 1-6烷基； R 4係H或C 1-6烷基； 或R 3及R 4與其等所附接之原子一起形成C 3-6環烷基； R 5係H或D； R 5A係H或D；且 L係鍵、羰基、可選地經取代之C 1-6伸烷基、可選地經取代之C 1-6伸烷基羰基、可選地經取代之C 2-6伸烯基羰基、可選地經取代之C 1-6鹵伸烷基羰基、或可選地經取代之-C(O)NR b(C 1-6伸烷基)-，其中該羰基之碳原子係連接至式 I中之N；且 R b係H或C 1-6烷基。
在其他態樣中，本揭露提供式 I-A、式 I-B、式 I-C、式 I-D、式 I-E、式 I-F、式 I-G、式 I-H、式 I-I、式 I-J、式 I-K、式 I-L、或式 I-M之化合物或其醫藥上可接受之鹽： I-A I-B I-C I-D I-E I-F I-G I-H I-I I-J I-K I-L I-M。
亦描述式 I、式 I-A、式 I-B、式 I-C、式 I-D、式 I-E、式 I-F、式 I-G、式 I-H、式 I-I、式 I-J、式 I-K、式 I-L、及式 I-M之化合物及其醫藥鹽之立體異構物及立體異構物之混合物。
在進一步態樣中，本揭露提供醫藥組成物，其包含一或多種本文所述之化合物或其醫藥上可接受之鹽、及醫藥上可接受之賦形劑。
在又其他態樣中，本揭露提供用於穩定突變PAH蛋白之方法，其包含使該蛋白質與一或多種本文所述之化合物或其醫藥上可接受之鹽接觸。在一些實施例中，突變PAH蛋白含有至少一個R408W、R261Q、R243Q、Y414C、L48S、A403V、I65T、R241C、L348V、R408Q、或V388M突變。在其他實施例中，突變PAH蛋白含有至少一個R408W、Y414C、I65T、F39L、R408Q、L348V、R261Q、A300S、或L48S突變。
在仍進一步態樣中，本揭露提供用於降低罹患苯酮尿症之對象之苯丙胺酸水平之方法，其包含投予治療有效量的一或多種如本文所述之化合物或其醫藥上可接受之鹽。
定義
除非另外定義，否則本文中所使用之所有技術及科學用語具有與本揭露所屬技術領域中具有通常知識者普遍理解相同的意義。實施方式中所使用之用語僅用於描述特定實施例且不意欲限制本揭露。
如本文結構中所使用，「 」指示特定描繪之結構或取代基與分子其餘部分中之（多個）適當原子之附接點。
除非上下文另有明確指示，否則如本文及隨附申請專利範圍中所使用，冠詞「一(a/an)」係指一個或多於一個（例如至少一個）該冠詞之語法受詞。舉實例而言，「一元件(an element)」意指一個元件或多於一個元件。
「醫藥上可接受(Pharmaceutically acceptable)」意指聯邦或州政府之監管機構或美國以外之國家的對應機構已核准或可核准的，或列於美國藥典(U.S. Pharmacopoeia)或其他公認用於動物（例如人類）的藥典中。
「醫藥上可接受之鹽(Pharmaceutically acceptable salt)」係指本揭露之化合物之鹽，其係醫藥上可接受的且具有母體化合物之所欲藥理活性。具體而言，此類鹽係無毒的且可係無機或有機酸加成鹽及鹼加成鹽。具體而言，此類鹽包括：(1)酸加成鹽，其用無機酸形成，諸如鹽酸、氫溴酸、硫酸、硝酸、磷酸、及類似者；或用有機酸形成，諸如乙酸、丙酸、己酸、環戊烷丙酸、乙醇酸、丙酮酸、乳酸、丙二酸、琥珀酸、蘋果酸、順丁烯二酸、反丁烯二酸、酒石酸、檸檬酸、苯甲酸、3-(4-羥基苯甲醯基)苯甲酸、肉桂酸、苦杏仁酸、甲磺酸、乙磺酸、1,2-乙烷-二磺酸、2-羥基乙磺酸、苯磺酸、4-氯苯磺酸、2-萘磺酸、4-甲苯磺酸、樟腦磺酸、4-甲基雙環[2.2.2]-辛-2-烯-1-羧酸、葡庚糖酸、3-苯基丙酸、三甲基乙酸、三級丁基乙酸、月桂基硫酸、葡萄糖酸、麩胺酸、羥基萘甲酸、水楊酸、硬脂酸、黏康酸、及類似者；或(2)在以下情況下形成之鹽：在母體化合物中存在之酸性質子被金屬離子（例如鹼金屬離子、鹼土金屬離子、或鋁離子）置換時；或與有機鹼（諸如乙醇胺、二乙醇胺、三乙醇胺、N-甲基還原葡糖胺、及類似者）配位時。僅舉實例而言，鹽進一步包括鈉、鉀、鈣、鎂、銨、四烷基銨、及類似者；及當化合物含有鹼性官能性時，包括無毒有機酸或無機酸之鹽，諸如鹽酸鹽、氫溴酸鹽、反丁烯二酸鹽、酒石酸鹽、甲磺酸鹽、乙酸鹽、順丁烯二酸鹽、草酸鹽、及類似者。
「醫藥上可接受之賦形劑(pharmaceutically acceptable excipient)」係指無毒、生物學上可耐受、及在其他方面生物學上適合投予至對象的物質，諸如惰性物質，其添加至藥理組成物中或以其他方式用作媒劑、載劑、或稀釋劑以促進藥劑之投予且與其相容。
當單獨或作為取代基之部分使用時，用語「烷基(alkyl)」係指在基團中具有1至12個碳原子（「C 1-12」）、例如1至6個碳原子（「C 1-6」）之直鏈或支鏈烴基。烷基之實例包括甲基(C 1)、乙基(C 2)、丙基(C 3)（例如正丙基、異丙基）、丁基(C 4)（例如正丁基、三級丁基、二級丁基、異丁基）、戊基(pentyl) (C 5)、（例如正戊基、3-戊基、戊基(amyl)、新戊基、3-甲基-2-丁基、三級戊基）、己基(C 6)（例如正己基）、庚基(C 7)（例如正庚基）、辛基(C 8)（例如正辛基）、及類似者。在一些實施例中，烷基係C 1-6烷基；在其他實施例中，其係C 1-4烷基；且在其他實施例中，其係C 1-3烷基。
當單獨或作為取代基之部分使用時，用語「伸烷基(alkylene)」係指烷基雙自由基，亦即附接至兩個其他基團之直鏈或支鏈烴基。例如，C 2伸烷基之一個實施例係雙自由基-CH 2CH 2-。在一些實施例中，伸烷基係C 1-6伸烷基；在其他實施例中，其係C 1-4伸烷基。
當在本文中使用碳原子範圍（例如C 1-6）時，涵蓋所有範圍以及個別碳原子數。例如，「C 1-3」包括C 1-3、C 1-2、C 2-3、C 1、C 2、及C 3。
當單獨或作為取代基之部分使用時，用語「環烷基(cycloalkyl)」係指具有3至10個碳原子（「C 3-10」）、例如3至7個碳原子（「C 3-7」）之含環狀之非芳族烴基。環烷基之實例包括環丙基(C 3)、環丁基(C 4)、環戊基(C 5)、環己基(C 6)、環庚基(C 7)、及類似者。在一些實施例中，環烷基係C 3-4環烷基；在其他實施例中，其係C 3-6環烷基；且在其他實施例中，其係C 3-8環烷基。環烷基可未經取代或經取代。在一些實施例中，環烷基經兩個取代基取代。在進一步實施例中，環烷基經一個取代基取代。在又其他實施例中，環烷基經三個取代基取代。在仍進一步實施例中，環烷基未經取代。
當單獨或作為取代基之部分使用時，用語「芳基(aryl)」亦指在環中具有6或10個碳原子之單環或雙環芳族烴環結構，其中環中碳原子中之一或多者可選地經取代。用語「芳基」亦包括在環中具有6或10個碳原子之單環或雙環芳族烴環結構，其中環中之兩個相鄰碳原子可選地經取代，使得該兩個相鄰碳原子與其等之各別取代基形成環烷基或雜環基環。芳基之實例包括苯基、茚基、萘基、1,2,3,4-四氫萘基、及類似者。芳基可未經取代或經取代。在其他實施例中，可選地經取代之苯基具有四個取代基。在進一步實施例中，可選地經取代之苯基具有三個取代基。在又其他實施例中，可選地經取代之苯基具有兩個取代基。在仍進一步實施例中，可選地經取代之苯基具有一個取代基。在其他實施例中，可選地經取代之苯基未經取代。
如本文中所使用，用語「烯基(alkenyl)」係指在基團中具有2至12個碳原子（「C 2-12」）之直鏈或支鏈基團，其中該基團包括至少一個碳-碳雙鍵。烯基之實例包括乙烯基（-CH=CH 2；C 2烯基）、烯丙基（-CH 2-CH=CH 2；C 3烯基）、丙烯基（-CH=CHCH 3；C 3烯基）、異丙烯基（-C(CH 3)=CH 2；C 3烯基）、丁烯基（-CH=CHCH 2CH 3；C 4烯基）、二級丁烯基（-C(CH 3)=CHCH 3；C 4烯基）、異丁烯基（-CH=C(CH 3) 2；C 4烯基）、2-丁烯基（-CH 2CH=CHCH 3；C 4烷基）、戊烯基（‑CH=CHCH 2CH 2CH 3；C 5烯基）、及類似者。在一些實施例中，烯基係C 2-6烯基；在其他實施例中，其係C 2-4烯基。
如本文中所使用，用語「炔基(alkynyl)」係指在基團中具有2至12個碳原子（「C 2-12」）之直鏈或支鏈基團，且其中該基團包括至少一個碳-碳參鍵。炔基之實例包括乙炔基（-C≡CH；C 2炔基）、炔丙基（-CH 2-C≡CH；C 3炔基）、丙炔基（-C≡CCH 3；C 3炔基）、丁炔基（-C≡CCH 2CH 3；C 4炔基）、戊炔基（‑C≡CCH 2CH 2CH 3；C 5炔基）、及類似者。在一些實施例中，炔基係C 2-6炔基；在其他實施例中，其係C 2-4炔基。
單獨或作為另一基團之部分使用之用語「羰基(carbonyl)」係指C(O)或C(=O)。
單獨或作為另一基團之部分使用之用語「烷基羰基(alkylcarbonyl)」係指如上所定義之烷基，其中至少一個碳係鍵結至側氧基。例如，C 3烷基羰基之一個實施例係-CH 2C(O)CH 3。在一些實施例中，烷基羰基係C 1-6烷基羰基。
單獨或作為另一基團之部分使用之用語「伸烯基羰基(alkenylenecarbonyl)」係指-C(O)-(伸烯基)基團，其中伸烯基係指伸烷基雙自由基，亦即含有至少一個附接至兩個其他基團之碳-碳雙鍵之直鏈或支鏈烴基。例如，-C(O)-C 2伸烯基之一個實施例係-C(O)-CH=CH-。在一些實施例中，伸烯基羰基之伸烯基係C 2-6伸烯基；在其他實施例中，伸烯基係C 2-4伸烯基。
單獨或作為另一基團之部分使用之用語「鹵基(halo)」或「鹵素(halogen)」係指氟、氯、溴、或碘原子。
如本文中所使用，用語「鹵烷基(haloalkyl)」係指其中一或多個氫原子已用一或多個可能相同或不同的鹵素原子置換之烷基。在一些實施例中，烷基經至少一個鹵素取代。在其他實施例中，烷基經一、二、或三個F及/或Cl取代。鹵烷基之實例包括氟甲基(CH 2F)、1-氟乙基(CH(CH 3)F)、2-氟乙基、二氟甲基(CHF 2)、三氟甲基(CF 3)、五氟乙基、1,1-二氟乙基(C(CH 3)F 2)、2,2-二氟乙基(CH 2CHF 2)、2,2,2-三氟乙基(CH 2CF 3)、2-氟丙-2-基(C(CH 3) 2F)、3,3,3-三氟丙基、4,4,4-三氟丁基、三氯甲基、及類似者。在一些實施例中，鹵烷基係C 1-6鹵烷基；在其他實施例中，其係C 1-4鹵烷基；且在其他實施例中，其係C 1-3鹵烷基。
單獨或作為另一基團之部分使用之用語「鹵伸烷基羰基(haloalkylenecarbonyl)」係指-C(O)-(鹵伸烷基)基團，其中鹵伸烷基係指鹵烷基雙自由基。例如，-C(O)-C 1鹵伸烷基之一個實施例係-C(O)-CF 2-。在一些實施例中，鹵伸烷基係C 1-6鹵伸烷基；在其他實施例中，其係C 1-4鹵伸烷基；且在其他實施例中，其係C 1-3鹵伸烷基。
單獨或作為另一基團之部分使用之用語「氰烷基(cyanoalkyl)」係指經一或多個CN取代之如本文中所定義之烷基。在一些實施例中，烷基經至少一個CN取代。在其他實施例中，烷基經一、二、或三個CN取代。在進一步實施例中，氰烷基係C 1-6氰烷基。在又其他實施例中，氰烷基係C 1-4氰烷基。氰烷基之實例包括CH 2CN、CH 2CH 2CN、CH(CN)CH 3、CH 2CH 2CH 2CN、C(CH 3) 2CN、CH 2CH(CN)CH 3、CH(CN)CH 2CH 3、及類似者。
單獨或作為另一基團之部分使用之用語「羥基烷基(hydroxyalkyl)」係指如本文中所定義之烷基，其中一或多個氫原子已用一或多個羥基（亦即-OH）置換。在一些實施例中，羥基烷基含有一個OH。在其他實施例中，羥基烷基含有兩個OH。在進一步實施例中，羥基烷基含有三個OH。羥基烷基之實例包括羥基甲基、羥基乙基（例如1-羥基乙基、2-羥基乙基）、1,2-二羥基乙基、羥基丙基（例如2-羥基丙基、3-羥基丙基）、羥基丁基（例如3-羥基丁基、4-羥基丁基）、2-羥基-1-甲基丙基、1,3-二羥基丙-2-基、及類似者。在一些實施例中，羥基烷基係C 1-6羥基烷基；在其他實施例中，其係C 1-4羥基烷基；且在其他實施例中，其係C 1-3羥基烷基。
單獨或作為另一基團之部分使用之用語「環烷基磺醯基(cycloalkylsulfonyl)」係指如本文中所定義之環烷基，其係結合至磺醯基（亦即-SO 2-），且磺醯基形成與分子其餘部分之附接點。在一些實施例中，環烷基磺醯基係C 3-8環烷基磺醯基；在其他實施例中，其係C 3-6環烷基磺醯基。環烷基磺醯基之實例包括-SO 2-環丙基、-SO 2-環丁基、-SO 2-環戊基、及類似者。
單獨或作為另一基團之部分使用之用語「烷基磺醯基(alkylsulfonyl)」係指如本文中所定義之烷基，其係結合至磺醯基（亦即-SO 2-），且磺醯基形成與分子其餘部分之附接點。在一些實施例中，烷基磺醯基係C 1-6烷基磺醯基；在其他實施例中，其係C 1-4烷基磺醯基。烷基磺醯基之實例包括-SO 2CH 3、-SO 2CH 2CH 3、及類似者。
單獨或作為另一基團之部分使用之用語「烷基磺醯基(伸烷基) (alkylsulfonyl(alkylene))」係指如本文中所定義之伸烷基，其係結合至如本文中所定義之烷基磺醯基之磺醯基。烷基磺醯基(伸烷基)基團之實例包括-C(CH 3) 2SO 2CH 3、-CH 2SO 2CH 3、-CH(CH 3)SO 2CH 3、及類似者。
單獨或作為另一基團之部分使用之用語「烷氧基(alkoxy)」係指藉由單鍵附接至烷基之氧自由基。烷氧基之實例包括甲氧基(OCH 3)、乙氧基(OCH 2CH 3)、丙氧基（例如-O nPr、-O iPr）、或丁氧基（例如-O nBu、-O iBu、-O sBu、-O tBu）、及類似者。在其他實施例中，烷氧基係C 1-6烷氧基。在進一步實施例中，烷氧基係C 1-4烷氧基。
單獨或作為另一基團之部分使用之用語「烷氧基(伸烷基)(alkoxy(alkylene))」係指如本文中所定義之伸烷基，其係結合至如本文中所定義之烷氧基。烷氧基(伸烷基)基團之實例包括-CH 2OCH 3、-CH 2CH 2OCH 3、及類似者。
單獨或作為另一基團之部分使用之用語「鹵烷氧基(haloalkoxy)」係指藉由單鍵附接至鹵烷基之氧自由基，其中鹵烷基係如上所定義。鹵烷氧基之實例包括氟甲氧基(OCH 2F)、2-氟乙氧基、二氟甲氧基(OCHF 2)、三氟甲氧基(OCF 3)、五氟乙氧基、1,1-二氟乙氧基(OC(CH 3)F 2)、2,2-二氟乙氧基、2,2,2-三氟乙氧基(OCH 2CF 3)、3,3,3-三氟丙氧基、4,4,4-三氟丁氧基、三氯甲氧基、及類似者。在一些實施例中，鹵烷氧基係C 1-6鹵烷氧基；在其他實施例中，其係C 1-4鹵烷氧基；且在其他實施例中，其係C 1-3鹵烷氧基。
單獨或作為另一基團之部分使用之用語「鹵烷氧基(伸烷基) (haloalkoxy(alkylene))」係指如本文中所定義之伸烷基，其係結合至如本文中所定義之鹵烷氧基。鹵烷氧基(伸烷基)基團之實例包括-CH 2OCF 3及類似者。
當單獨或作為取代基之部分使用時，用語「雜芳基(heteroaryl)」係指包括碳原子以及至多四個各自獨立地係氮、氧、或硫之雜原子的單環或雙環芳族環結構。雜芳基環可包括總共5、6、9、或10個環原子。在一些實施例中，雜芳基環係藉由雜芳基中之環原子數目表徵。例如，6員雜芳基係指基團中具有6個環原子之雜芳基。類似地，5員雜芳基係指基團中具有5個環原子之雜芳基。雜芳基部份可未經取代，或環中碳原子或氮原子中之一或多者可經取代。雜芳基之實例包括噻吩基、苯并[b]噻吩基、呋喃基、苯并呋喃基、哌喃基、苯硫基、異苯并呋喃基、苯并㗁𠯤基、 唏基、𠮿基、2H吡咯基、吡咯基、咪唑基、吡唑基、吡啶基、吡𠯤基、嘧啶基、嗒𠯤基、異吲哚基、3H-吲哚基、吲哚基、吲唑基、嘌呤基、異喹啉基、喹啉基、喹㗁啉基(quinoxalyl)、呔𠯤基、㖠啶基、㖕啉基、三唑基、四唑基、噻二唑基、㗁二唑基、喹唑啉基、喋啶基、嘧啶基、噻唑基、異噻唑基、㗁唑基、異㗁唑基、呋呫基、吡唑并[1,5-a]吡啶基、苯并異噻唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2]嗒𠯤基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯異㗁唑基、異噻唑基、四氫吡唑并[1,5-a]吡啶基、及類似者。在一些實施例中，雜芳基係噻吩基（例如噻吩-2-基及噻吩-3-基）、呋喃（例如2-呋喃基、3-呋喃基、4-呋喃基）、吡咯基（例如吡咯-2-基、吡咯-3-基）、咪唑基（例如咪唑-2-基、咪唑-4-基）、吡唑基（例如吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基）、吡啶基（例如吡啶-1-基、吡啶-2-基、吡啶-3-基、及吡啶-4-基）、嘧啶基（例如嘧啶-2-基、嘧啶-4-基、及嘧啶-5-基）、噻唑基（例如噻唑-2-基、噻唑-4-基、及噻唑-5-基）、異噻唑基（例如異噻唑-3-基、異噻唑-4-基、及異噻唑-5-基）、㗁唑基（例如㗁唑-2-基、㗁唑-4-基、及㗁唑-5-基）、異㗁唑基（例如異㗁唑-3-基、異㗁唑-4-基、及異㗁唑-5-基）、吡𠯤基（例如吡𠯤-2-基、吡𠯤-3-基、吡𠯤-5-基、吡𠯤-6-基)、三唑基（例如1,2,4-三唑-1-基、1,2,4-三唑-3-基、1,2,4-三唑-5-基）、噻二唑基（例如1,2,3-噻二唑基、1,2,4-噻二唑基、1,2,5-噻唑基、1,3,4-噻二唑基）、㗁二唑基（例如1,2,3-㗁二唑基、1,2,4-㗁二唑基、1,2,5-㗁二唑基、1,3,4-㗁二唑基）、吲唑基（例如吲唑-3-基）、吡唑并[1,5-a]吡啶基（例如吡唑并[1,5-a]吡啶-3-基）、咪唑[1,5-a]吡啶基（例如咪唑[1,5-a]吡啶-1-基）、吡咯并[1,2]嗒𠯤基（例如吡咯并[1,2]嗒𠯤-5-基、吡咯并[1,2]嗒𠯤-6-基）、苯并[d]噻唑基（例如苯并[d]噻唑-3-基、苯并[d]噻唑-2-基）、苯并[d]咪唑基（例如苯并[d]咪唑-2-基）、苯并[d]㗁唑基（例如苯并[d]㗁唑-2-基）、苯并[d]異㗁唑基（例如苯并[d]異㗁唑-3-基）、苯并[d]異噻唑基（例如苯并[d]異噻唑-3-基）、苯并[c]異㗁唑基（例如苯并[c]異㗁唑-3-基）、喹啉基（例如喹啉-3-基）、及嗒𠯤基（例如嗒𠯤-3-基、嗒𠯤-4-基）。用語「雜芳基(heteroaryl)」亦包括N-氧化物。雜芳基可未經取代或經取代。在一些實施例中，雜芳基經兩個取代基取代。在進一步實施例中，雜芳基經一個取代基取代。在又其他實施例中，雜芳基經三個取代基取代。在仍進一步實施例中，雜芳基未經取代。取代可在任何可用的碳或雜原子（例如氮）上或兩者上，如取代基化合價所允許的。
在一些實施例中，雜芳基係5員或6員雜芳基。在一些實施例中，雜芳基係5員雜芳基，即，雜芳基係具有5個環原子之單環芳族環系統，其中該環之至少一個碳原子經獨立地選自氮、氧、及硫之雜原子置換。5員雜芳基之實例包括噻吩基、呋喃基、吡咯基、㗁唑基、吡唑基、咪唑基、噻唑基、異噻唑基、及異㗁唑基、及類似者。在其他實施例中，雜芳基係6員雜芳基，例如，雜芳基係具有6個環原子之單環芳族環系統，其中環之至少一個碳原子用氮原子置換。6員雜芳基之實例包括吡啶基、吡𠯤基、嘧啶基、嗒𠯤基、及類似者。
單獨或作為另一基團之部分使用之用語「雜環基(heterocyclyl)」係指非芳族、飽和或部分不飽和，例如含有一或兩個雙鍵、含有一、二、或三個環之環狀基團，其具有三至十四個環成員，亦即3至14員雜環基，其中該等環中之一者之至少一個碳原子經雜原子置換。各雜原子獨立地選自氧、硫（包括亞碸及碸）、及/或氮原子，其可經氧化或四級化。用語「雜環基(heterocyclyl)」亦包括環-CH 2-係用-C(O)-置換之基團。用語「雜環基」亦包括具有稠合可選地經取代之芳基的基團（例如吲哚啉基或 -4-基）及具有稠合可選地經取代之環烷基（例如6-氮雜螺[2.5]辛基）。在一些實施例中，雜環基係C 4-6雜環基，亦即含有一個環及一或兩個氧及/或氮原子之4、5、或6員環狀基團。在其他實施例中，雜環基係含有一個環及一個氮原子之C 4-6雜環基。雜環基可藉由任何可用碳或雜原子連接至分子之其餘部分，從而得到穩定結構。雜環基之實例包括吖呾基、二㗁烷基、四氫哌喃基、吡咯啶基、哌啶基、 啉基、哌𠯤基、吡咯啶基、吲哚啉基、氧呾基、四氫呋喃基、四氫苯硫基、吖環庚烷基、氮丙啶基、二氧雜環戊烷基、咪唑啶基、吡唑啶基、噻烷基、二噻烷基、硫 啉基、㗁吖環庚烷基、氧 基、四氫哌喃基、及類似者。在一些實施例中，雜環基包括吖呾基、吡咯啶基、哌啶基、哌𠯤基、 啉基、及6-氮雜螺[2.5]辛基。雜環基可未經取代或經取代。在一些實施例中，雜環基經兩個取代基取代。在進一步實施例中，雜環基經一個取代基取代。在又其他實施例中，雜環基經三個取代基取代。在仍進一步實施例中，雜環基未經取代。
單獨或作為另一基團之部分使用之用語「(雜環基)伸烷基((heterocyclyl)alkylene)」係指如本文中所定義之伸烷基，其係結合至如本文中所定義之雜環基。
本文中用於描述本文中所定義之化學部份之用語「可選地經取代(optionally substituted)」意指部份可以但不需要經一或多個合適的官能基或如本文所提供之其他取代基取代。例如，取代基可以可選地經下列中之一或多者取代：鹵基、氰基、-NO 2、-N 3、-OH、-SH、C 1-6烷基、C 3-8環烷基、C 3-8環烯基、C 2-6烯基、C 2-6炔基、C 1-6鹵烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 1-6烷基羰基、C 1-6氰烷基、C 1-6羥基烷基、C 1-6伸烷基硫基、(CR vR x) pNR yR z（其中R v及R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6羥基烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、或C(O)OC 1- 6烷基，且p係0、1、2、或3）、-C(O)NH 2、-C(O)NHC 1-6烷基、-C(O)N(C 1-6烷基) 2、-C(O)NHC 3-6環烷基、-C(O)N(C 3-6環烷基) 2、-COOH、-C 1-6伸烷基COOH、-C 3-6環烷基COOH、-C 1-6伸烷基CONH 2、C 3-6環烷基CONH 2、-C 1-6伸烷基CONHC 1-6烷基、-C 1-6伸烷基CON(C 1-6烷基) 2、-C(O)OC 1-6烷基、-NHCO(C 1-6烷基)、-N(C 1-6烷基)C(O)(C 1-6烷基)、-S(O)C 1-6烷基、-S(O)C 3-6環烷基、C 1-6烷基磺醯基、C 3-8環烷基磺醯基、C 1-6烷基磺醯基(伸烷基)、側氧基(=O)、3至7員雜環基、雜環基(伸烷基)、芳基、芳基(伸烷基)、或雜芳基。在一些實施例中，此段落中取代基中之任一者中之C 1-6烷基係C 1-4烷基；在其他實施例中，其係C 1-3烷基。在一些實施例中，此段落中取代基中之任一者中之C 1-6伸烷基係C 1-4伸烷基。在一些實施例中，C 1-6鹵烷基取代基係C 1-4鹵烷基；在其他實施例中，其係C 1-3鹵烷基。在一些實施例中，C 3-6環烷基取代基係C 3-4環烷基取代基。在一些實施例中，C 1-6烷氧基取代基係C 1-3烷氧基；在其他實施例中，其係C 1-4烷氧基。在一些實施例中，C 1-6鹵烷氧基取代基係C 1-3鹵烷氧基；在其他實施例中，其係C 1-4鹵烷氧基。
在一些實施例中，取代基可以可選地經下列中之一或多者取代：C 1-6烷基、可選地經取代之C 2-6烯基、鹵基、CN、C 1-6氰烷基、C 1-6鹵烷基、OH、可選地經取代之C 3-8環烷基、可選地經取代之C 3-8環烯基、可選地經取代之芳基、可選地經取代之芳基(伸烷基)、可選地經取代之雜芳基、可選地經取代之雜環基、可選地經取代之雜環基(伸烷基)、C 1-6羥基烷基、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6氘化烷氧基(伸烷基)、C 1-6烷基羰基、C 3-8環烷基磺醯基、C 1-6烷基磺醯基(伸烷基)、(CR vR x) pNR yR z（其中R v及R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6羥基烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、或C(O)OC 1-6烷基，且p係0、1、2或3）、及C(O)NR y2R z2（其中R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基）。
用語「氮保護基(nitrogen protecting group)」係指附接至氮原子以防止在該氮原子處反應之部份。氮保護基將由所屬技術領域中具有通常知識者已知，且包括描述於Wuts, P.G., Greene's Protective Groups in Organic Synthesis. Wiley; 5th edition (October 27, 2014)中者，其以引用方式併入本文中。
除非本文中另有指示，否則本文中之值範圍的敘述意欲充當單獨提及落入該範圍內的每個單獨值的速記方法，並且每個單獨值皆併入本說明書中，如同其在本文中被單獨敘述一樣。除非另外主張，否則本文提供之任何及所有實例或例示性語言（例如，「諸如(such as)」）的使用意欲更好地說明本揭露，並且非對本揭露範疇之限制。本說明書中之語言皆不應被解釋為指示任何未主張之元件對於實施本揭露必不可少。
當與數值或值範圍組合使用時，用語「約(about)」意指該值或值範圍可以偏離所屬技術領域中具有通常知識者認為合理之程度。
本文所述之化合物可包含一或多個不對稱中心，且因此可以各種立體異構形式，例如鏡像異構物及/或非鏡像異構物存在。例如，本文所述之化合物可係單獨的鏡像異構物、非鏡像異構物或幾何異構物的形式，或者可係立體異構物的混合物的形式，包括外消旋混合物及富含一或多種立體異構物的混合物。異構物可藉由所屬技術領域中具有通常知識者已知之方法，包括超臨界流體層析(supercritical fluid chromatography, SFC)、掌性高壓液相層析(chiral high-pressure liquid chromatography, HPLC)及掌性鹽之形成及結晶而自混合物單離；或較佳異構物可藉由不對稱合成來製備。參見例如Jacques et al., Enantiomers, Racemates and Resolutions (Wiley Interscience, New York, 1981)；Wilen et al., Tetrahedron 33:2725 (1977)；Eliel, E.L. Stereochemistry of Carbon Compounds (McGraw-Hill, NY, 1962)；及Wilen, S.H. Tables of Resolving Agents and Optical Resolutions p. 268 (E.L. Eliel, Ed., Univ. of Notre Dame Press, Notre Dame, IN 1972)。
包括掌性中心之本揭露之例示性化合物在本文中可描繪為具有特定立體化學，但未獲得絕對立體化學。可使用此項技術領域中已知之方法獲得絕對構形。
如本文中所使用，用語「立體異構物(stereoisomer)」係指具有相同化學構成及連接性但在原子或基團在空間中之配置方面不同之化合物，例如鏡像異構物或非鏡像異構物。
當具有一或多個掌性中心之化合物中之掌性中心處的立體化學構形藉由其化學名稱（例如，其中構形係在化學名稱中藉由「R」或「S」指示）或結構（例如，構形係藉由虛線或楔形鍵指示）描繪時，所指示構形相對於相反構形之富集大於50%、60%、70%、80%、90%、99%、或99.9%。「所指示構形相對於相反構形之富集」係莫耳百分比，且係藉由將在（多個）掌性中心處具有所指示立體化學構形之化合物的數目除以混合物中具有相同或相反立體化學構形之所有化合物的總數目來判定。
當所揭示之化合物被結構命名或描繪而不指示立體化學時，應理解，該名稱或結構涵蓋可能的立體異構物或幾何異構物中之一者，或所涵蓋的立體異構物或幾何異構物之混合物。
應理解，本文中所揭示之某些化合物可以互變異構形式存在。此類形式被包括作為本揭露之部分。因此，當本文中之化合物由結構式表示或由本文中之化學名稱指示，該化合物之所有可能存在之互變異構形式皆由該結構式涵蓋。
當本文所述之化合物含有烯屬雙鍵或其他幾何不對稱中心時，除非另外規定，否則其意欲包括E與Z幾何異構物二者。
在一些實施例中，本文所述之化合物係經同位素富集之化合物，例如類同位素分子。用語「經同位素富集(isotopically enriched)」係指原子之同位素組成不同於該原子之天然豐富同位素組成。「經同位素富集」亦可指化合物所含有之至少一個原子之同位素組成不同於該原子之天然同位素組成。在類同位素分子中，「同位素富集(isotopic enrichment)」係指在分子中給定原子之一定量的特定同位素併入而取代該原子之天然同位素組成之百分比。例如，在給定位置處1%之氘富集意指在給定樣本中1%的分子在指定位置處含有氘。由於氘之天然存在分布係約0.0156%，因此在使用非富集起始材料合成之化合物中之任何位置處的氘富集係約0.0156%。在一個實施例中，所描述化合物上之一或多個氫原子可由氘置換。
因此，如本文中所使用，且除非另外指示，否則用語「同位素富集因子(isotopic enrichment factor)」係指指定同位素的同位素組成與天然同位素組成之間的比率。
關於本文所提供之化合物，當特定原子之位置被指定為具有氘或「D」或「 2H」時，應理解該位置處之氘豐度大於氘之天然豐度，氘之天然豐度係約0.015%。在特定實施例中，指定為具有氘的位置通常在每一指定的氘原子處具有至少1000（15%的氘併入）、至少2000（30%的氘併入）、至少3000（45%的氘併入）、至少3500（52.5%的氘併入）、至少4000（60%的氘併入）、至少5500（82.5%的氘併入）、至少6000（90%的氘併入）、至少6333.3（95%的氘併入）、至少6466.7（97%的氘併入）、至少6600（99%的氘併入）、或至少6633.3（99.5%的氘併入）之最小同位素富集因子。本文提供之化合物的同位素富集及同位素富集因子可以使用所屬技術領域中具有通常知識者已知之常規分析方法（包括質譜法及核磁共振光譜法）來判定。
在整個說明書中使用用語「患者(patient)」或「對象(subject)」來描述動物，較佳為人類或馴養動物，向該等提供以根據本揭露之化合物或組成物進行之治療，包括預防性治療。對於特定動物（諸如人類患者）特有之病況或疾病狀態之治療，用語患者係指該特定動物，包括馴養動物（諸如狗或貓）或農場動物（諸如馬、乳牛、羊等）。通常，在本揭露中，用語患者係指人類患者，除非使用該用語之上下文中另有說明或暗示。
用語「治療有效量(therapeutically effective amount)」或「有效量(effective amount)」意指本揭露之化合物（或其醫藥上可接受之鹽）之量或劑量足以在需要對指定疾病或病症進行此類治療之對象中普遍產生所欲治療益處。此外，關於本揭露之化合物之治療有效量意指單獨或與其他療法組合之量，該量提供治療或預防疾病之治療益處。
任何疾病或病症之「治療(treating)」或「治療(treatment)」係指在一個實施例中，改善疾病或病症（例如，遏制或減少疾病之發展或其臨床症狀中之至少一者）。在另一實施例中，「治療(treating)」或「治療(treatment)」係指改善對象可能不可辨別之至少一個物理參數。在又另一實施例中，「治療(treating)」或「治療(treatment)」係指物理上（例如可辨別症狀之穩定）、生理上（例如物理參數之穩定）調節疾病或病症、或兩者。在又另一實施例中，「治療(treating)」或「治療(treatment)」係指延遲疾病或病症的發作。
用語「預防(prevent)」、「預防(preventing)」、及「預防(prevention)」係指藉由投予預防劑或治療劑來預防對象之疾病的發作、復發或擴散。 化合物
本揭露提供式 I之化合物或其醫藥上可接受之鹽： I
在式 I中，m係1或2。在一些實施例中，m係1。在其他實施例中，m係2。
在式 I中，R 1係 。
在R 1之結構中，x係0至5。在一些實施例中，x係0。在其他實施例中，x係1。在進一步實施例中，x係2。在又其他實施例中，x係3。在仍進一步實施例中，x係4。在其他實施例中，x係5。
在進一步實施例中，R 1係 ，且x係0或1，諸如 、 、 、 、 、或 。在其他實施例中，R 1係 。在又其他實施例中，R 1係 。在仍其他實施例中，R 1係 。在又其他實施例中，R 1係 。在仍進一步實施例中，R 1係 。在其他實施例中，R 1係 。
在一些實施例中，化合物係單一鏡像異構物，且R 1部份呈α構形。在一些實施例中，化合物係單一鏡像異構物，且R 1部份呈β構形。
在R 1之結構中，各R a獨立地係鹵基、C 1-6烷基、C 3-6環烷基、C 1-6鹵烷基、C 1-6烷氧基、或C 1-6鹵烷氧基。在一些實施例中，R a係鹵基，諸如F、Cl、Br、或I。在其他實施例中，R a係F、Br、或Cl。在仍其他實施例中，R a係F。在進一步實施例中，R a係Br。在又其他實施例中，R a係Cl。在仍進一步實施例中，R a係I。在其他實施例中，R a係C 1-6烷基，諸如甲基、乙基、丙基、丁基、戊基、或己基。在進一步實施例中，R a係甲基、乙基、或異丙基。在又其他實施例中，R a係甲基。在進一步實施例中，R a係C 3-6環烷基，諸如環丙基、環丁基、環戊基、或環己基。在仍進一步實施例中，R a係環丙基。在又其他實施例中，R a係C 1-6鹵烷基，諸如CF 3、CHF 2、CH 2F、CH 2CF 3、C(CH 3) 2F、或C(CH 3)F 2。在仍其他實施例中，R a係CF 3或CHF 2。在進一步實施例中，R a係C 1-6烷氧基，諸如甲氧基、乙氧基、丙氧基、丁氧基、戊氧基、或己氧基。在又其他實施例中，R a係甲氧基或乙氧基。在其他實施例中，R a係C 1-6鹵烷氧基，諸如OCF 3或OCH 2CF 3。在仍其他實施例中，一個R a係鹵基，且第二個R a係C 1-6烷氧基或C 1-6烷基。
在式 I中，R 2係C 1-4烷基、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、或可選地經取代之雜芳基。在一些實施例中，R 2係可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、或可選地經取代之雜芳基。在進一步實施例中，R 2係未經取代之C 3-8環烷基、未經取代之雜環基、未經取代之芳基、或未經取代之雜芳基。在其他實施例中，R 2係經取代之C 3-8環烷基、經取代之雜環基、經取代之芳基、或經取代之雜芳基。在一些實施例中，R 2係C 1-4烷基，諸如甲基、乙基、丙基、丁基、或三級丁基。在其他實施例中，R 2係可選地經取代之C 3-8環烷基，諸如環丙基、環丁基、環戊基、環己基、環庚基、或環辛基。在進一步實施例中，R 2係可選地經取代之雜環基，諸如吖呾基。在仍其他實施例中，R 2係可選地經取代之芳基，諸如苯基。在又進一步實施例中，R 2係可選地經取代之雜芳基，諸如吡啶基、吡唑基、㗁唑基、異㗁唑基、噻唑基、異噻唑基、三唑基、㗁二唑基、噻二唑基、呋喃基、苯硫基、嘧啶基、吡𠯤基、吲唑基、吡唑并[1,5-a]吡啶基、咪唑[1,5-a]吡啶基、吡咯并[1,2-b]嗒𠯤基、苯并[d]噻唑基、苯并[d]異噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、或苯并[d]異噻唑基。
在式 I中，R 3係H或C 1-6烷基。在一些實施例中，R 3係H。在其他實施例中，R 3係C 1-6烷基，諸如甲基、乙基、丙基、丁基、戊基、或己基。在進一步實施例中，R 3係甲基。在又其他實施例中，R 3係乙基。在仍進一步實施例中，R 3係丙基。在其他實施例中，R 3係丁基。在進一步實施例中，R 3係戊基。在又其他實施例中，R 3係己基。
在式 I中，R 4係H或C 1-6烷基。在一些實施例中，R 4係H。在其他實施例中，R 4係C 1-6烷基，諸如甲基、乙基、丙基、丁基、戊基、或己基。在進一步實施例中，R 4係甲基。在又其他實施例中，R 4係乙基。在仍進一步實施例中，R 4係丙基。在其他實施例中，R 4係丁基。在進一步實施例中，R 4係戊基。在又其他實施例中，R 4係己基。
替代地，R 3及R 4與其等所附接之原子一起形成C 3-6環烷基。在一些實施例中，R 3及R 4一起形成環丙基。在其他實施例中，R 3及R 4一起形成環丁基。在進一步實施例中，R 3及R 4一起形成環戊基。在又其他實施例中，R 3及R 4一起形成環己基。
在一些實施例中，R 3及R 4兩者係H。在其他實施例中，R 3係甲基，且R 4係H。在仍其他實施例中，R 3及R 4兩者係甲基。
在式 I中，R 5係H或D。在一些實施例中，R 5係H。在進一步實施例中，R 5係D。
在式 I中，R 5A係H或D。在一些實施例中，R 5A係H。在進一步實施例中，R 5A係D。
在式 I中，L係鍵、羰基、可選地經取代之C 1-6伸烷基、可選地經取代之C 1-6伸烷基羰基、可選地經取代之C 2-6伸烯基羰基、可選地經取代之C 1-6鹵伸烷基羰基、或可選地經取代之-C(O)NR b(C 1-6伸烷基)-，其中該羰基之碳原子係連接至式 I中之N。在一些實施例中，L係鍵。在其他實施例中，L係羰基（其中羰基之碳原子連接至式 I中之N）。在進一步實施例中，L係可選地經取代之C 1-6伸烷基，諸如伸甲基、伸乙基、伸丙基、伸丁基、伸戊基、或伸己基。在其他實施例中，L係C 1伸烷基。在仍其他實施例中，L係C 2伸烷基。在進一步實施例中，L係C 3伸烷基。在又其他實施例中，L係C 4伸烷基。在仍進一步實施例中，L係C 5伸烷基。在其他實施例中，L係C 6伸烷基。在又其他實施例中，L係可選地經取代之C 1-6伸烷基羰基（其中該羰基之碳原子連接至式 I中之N）。在進一步實施例中，L係-C 1伸烷基-C(O)-。在其他實施例中，L係-C 2伸烷基-C(O)-。在進一步實施例中，L係-C 3伸烷基-C(O)-。在又其他實施例中，L係-C 4伸烷基-C(O)-。在仍進一步實施例中，L係-C 5伸烷基-C(O)-。在其他實施例中，L係-C 6伸烷基-C(O)-。在仍進一步實施例中，L係可選地經取代之C 2-6伸烯基羰基（其中該羰基之碳原子連接至式 I中之N）。在其他實施例中，L係-C 2伸烯基-C(O)-。在進一步實施例中，L係-C 3伸烯基-C(O)-。在又其他實施例中，L係-C 4伸烯基-C(O)-。在仍進一步實施例中，L係-C 5伸烯基-C(O)-。在其他實施例中，L係-C 6伸烯基-C(O)-。在其他實施例中，L係可選地經取代之C 1-6鹵伸烷基羰基（其中該羰基之碳原子連接至式 I中之N）。在又其他實施例中，L係-C 1鹵伸烷基-C(O)-。在其他實施例中，L係-C 2鹵伸烷基-C(O)-。在進一步實施例中，L係-C 3鹵伸烷基-C(O)-。在又其他實施例中，L係-C 4鹵伸烷基-C(O)-。在仍進一步實施例中，L係-C 5鹵伸烷基-C(O)-。在其他實施例中，L係-C 6鹵伸烷基-C(O)-。在進一步實施例中，L係-C(O)NR b(C 1-6伸烷基)-（其中該羰基之碳原子連接至式 I中之N）。在又其他實施例中，L係-C(O)NR bC 1伸烷基-。在其他實施例中，L係-C(O)NR bC 2伸烷基-。在進一步實施例中，L係-C(O)NR bC 3伸烷基-。在又其他實施例中，L係-C(O)NR bC 4伸烷基-。在仍進一步實施例中，L係-C(O)NR bC 5伸烷基-。在其他實施例中，L係-C(O)NR bC 6伸烷基-。
在L之結構中，R b係H或C 1-6烷基。在一些實施例中，R b係H。在其他實施例中，R b係C 1-6烷基，諸如甲基、乙基、丙基、丁基、戊基、或己基。在進一步實施例中，R b係甲基。在又其他實施例中，R b係乙基。在仍進一步實施例中，R b係丙基。在其他實施例中，R b係丁基。在進一步實施例中，R b係戊基。在又其他實施例中，R b係己基。
在一些實施例中，L係鍵、-C(O)-、-C(O)CH 2-、-C(O)CH 2CH 2-、-C(O)CH 2CH 2CH 2-、-C(O)CF 2-、-C(O)CHF-、-C(O)C(CH 3) 2-、-C(O)CH=CH-、 、-C(O)NHCH 2-、-CH 2-、或-CH 2CH 2-。在又其他實施例中，L係鍵、-C(O)-、-C(O)CH 2-、或-C(O)CF 2。
在一些實施例中，R 2係環戊基、環丁基、環丙基、吖呾基、苯基、吡唑基、㗁唑基、噻唑基、三唑基、㗁二唑基、吡啶基、嘧啶基、吡唑并[1,5-a]吡啶基、吲唑基、噻二唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2]嗒𠯤基、苯硫基、異㗁唑基、異噻唑基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、苯并[d]異噻唑基、呋喃基、或吡𠯤基，其中之各者可選地經取代。
在進一步實施例中，R 2係環戊基、環丁基、環丙基、環己基、吖呾基、苯基、吡唑基、㗁唑基、噻唑基、三唑基、㗁二唑基、吡啶基、嘧啶基、吡唑并[1,5-a]吡啶基、吲唑基、噻二唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2]嗒𠯤基、苯硫基、異㗁唑基、異噻唑基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、苯并[c]異㗁唑基、苯并[d]異噻唑基、呋喃基、吡𠯤基、或喹啉基，其中之各者可選地經取代。
在其他實施例中，R 2係環戊基、環丁基、環丙基、吖呾基、苯基、吡唑基、㗁唑基、噻唑基、三唑基、㗁二唑基、吡啶基、嘧啶基、吡唑并[1,5-a]吡啶基、吲唑基、噻二唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2]嗒𠯤基、苯硫基、異㗁唑基、異噻唑基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、苯并[d]異噻唑基、呋喃基、或吡𠯤基，其中之各者未經取代。
在又其他實施例中，R 2係環戊基、環丁基、環丙基、環己基、吖呾基、苯基、吡唑基、㗁唑基、噻唑基、三唑基、㗁二唑基、吡啶基、嘧啶基、吡唑并[1,5-a]吡啶基、吲唑基、噻二唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2]嗒𠯤基、苯硫基、異㗁唑基、異噻唑基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、苯并[c]異㗁唑基、苯并[d]異噻唑基、呋喃基、吡𠯤基、或喹啉基，其中之各者未經取代。
在進一步實施例中，R 2係可選地經取代之環戊基。在進一步實施例中，R 2係可選地經取代之環丁基。在仍其他實施例中，R 2係可選地經取代之環丙基。在又其他實施例中，R 2係可選地經取代之環己基。在又進一步實施例中，R 2係可選地經取代之吖呾基。在其他實施例中，R 2係可選地經取代之苯基。在進一步實施例中，R 2係可選地經取代之吡唑基。在仍其他實施例中，R 2係可選地經取代之㗁唑基。在又進一步實施例中，R 2係可選地經取代之噻唑基。在其他實施例中，R 2係可選地經取代之三唑基。在進一步實施例中，R 2係可選地經取代之㗁二唑基。在仍其他實施例中，R 2係可選地經取代之吡啶基。在又進一步實施例中，R 2係可選地經取代之嘧啶基。在其他實施例中，R 2係可選地經取代之吡唑并[1,5-a]吡啶基。在進一步實施例中，R 2係可選地經取代之吲唑基。在又其他實施例中，R 2係可選地經取代之噻二唑基。在其他實施例中，R 2係可選地經取代之咪唑[1,5-a]吡啶基。在進一步實施例中，R 2係可選地經取代之吡咯并[1,2]嗒𠯤基。在仍其他實施例中，R 2係可選地經取代之苯硫基。在又進一步實施例中，R 2係可選地經取代之異㗁唑基。在進一步實施例中，R 2係可選地經取代之異噻唑基。在其他實施例中，R 2係可選地經取代之苯并[d]噻唑基。在進一步實施例中，R 2係可選地經取代之苯并[d]咪唑基。在仍其他實施例中，R 2係可選地經取代之苯并[d]㗁唑基。在又進一步實施例中，R 2係苯并[d]異㗁唑基。在又其他實施例中，R 2係可選地經取代之苯并[c]異㗁唑基。在仍進一步實施例中，R 2係可選地經取代之苯并[d]異噻唑基。在其他實施例中，R 2係可選地經取代之呋喃基。在又其他實施例中，R 2係可選地經取代之吡𠯤基。在仍進一步實施例中，R 2係可選地經取代之喹啉基。
在其他實施例中，R 2係吖呾-1-基、吖呾-3-基、吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、1,2,4-三唑-1-基、1,2,4-三唑-3-基、1,2,4-三唑-5-基、1,2,3-三唑-5-基、1,3,4-㗁二唑-2-基、1,2,4-㗁二唑-3-基、1,2,4-㗁二唑-5-基、吡唑并[1,5-a]吡啶-3-基、吲唑-3-基、噻唑-2-基、噻唑-4-基、噻唑-5-基、㗁唑-2-基、㗁唑-4-基、㗁唑-5-基、1,3,4-噻二唑-2-基、吡啶-1-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、嘧啶-2-基、咪唑[1,5-a]吡啶-1-基、吡咯并[1,2]嗒𠯤-5-基、吡咯并[1,2]嗒𠯤-6-基、苯硫-2-基、異㗁唑-3-基、異㗁唑-4-基、異㗁唑-5-基、苯并[d]噻唑-2-基、苯并[d]噻唑-3-基、苯并[d]咪唑-2-基、苯并[d]㗁唑-2-基、苯并[d]異㗁唑-3-基、苯并[d]異噻唑-3-基、呋喃-3-基、異噻唑-3-基、異噻唑-4-基、異噻唑-5-基、或吡𠯤-2-基，其中之各者可選地經取代。
在又其他實施例中，R 2係吖呾-1-基、吖呾-3-基、吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、1,2,4-三唑-1-基、1,2,4-三唑-3-基、1,2,4-三唑-5-基、1,2,3-三唑-5-基、1,3,4-㗁二唑-2-基、1,2,4-㗁二唑-3-基、1,2,4-㗁二唑-5-基、吡唑并[1,5-a]吡啶-3-基、吲唑-3-基、噻唑-2-基、噻唑-4-基、噻唑-5-基、㗁唑-2-基、㗁唑-4-基、㗁唑-5-基、1,3,4-噻二唑-2-基、吡啶-1-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、嘧啶-2-基、咪唑[1,5-a]吡啶-1-基、吡咯并[1,2]嗒𠯤-5-基、吡咯并[1,2]嗒𠯤-6-基、苯硫-2-基、異㗁唑-3-基、異㗁唑-4-基、異㗁唑-5-基、苯并[d]噻唑-2-基、苯并[d]噻唑-3-基、苯并[d]咪唑-2-基、苯并[d]㗁唑-2-基、苯并[d]異㗁唑-3-基、苯并[d]異噻唑-3-基、呋喃-3-基、異噻唑-3-基、異噻唑-4-基、異噻唑-5-基、吡𠯤-2-基、苯并[c]異㗁唑-3-基、或喹啉-3-基，其中之各者可選地經取代。
在進一步實施例中，R 2係C 3-8環烷基、雜環基、芳基、或雜芳基，其中之各者經下列中之一或多者取代：C 1-6烷基、可選地經取代之C 2-6烯基、鹵基、CN、C 1-6氰烷基、C 1-6鹵烷基、OH、可選地經取代之C 3-8環烷基、可選地經取代之C 3-8環烷基(伸烷基)、可選地經取代之C 3-8環烯基、可選地經取代之芳基、可選地經取代之芳基(伸烷基)、可選地經取代之雜芳基、可選地經取代之雜環基、可選地經取代之雜環基(伸烷基)、C 1-6羥基烷基、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6氘化烷氧基(伸烷基)、C 1-6烷基羰基、C 3-8環烷基磺醯基、C 1-6烷基磺醯基、C 1-6烷基磺醯基(伸烷基)、(CR vR x) pNR yR z（其中R v基R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6羥基烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、或C(O)OC 1-6烷基，且p係0、1、2或3）、或C(O)NR y2R z2（其中R y2及R z2獨立地係H、C 1-6烷基或C 3-6環烷基）。在其他實施例中，R 2可選地經C 1-6烷基取代，諸如甲基、乙基、丙基、異丙基、或三級丁基。在又進一步實施例中，R 2可選地經C 2-6烯基取代，諸如CH=CH 2、CH=CHC(CH 3) 2OH、或CH=CH-環丙基。在進一步實施例中，R 2可選地經鹵基取代，諸如Br、Cl、或F。在又其他實施例中，R 2可選地經CN取代。在仍進一步實施例中，R 2可選地經C 1-6氰烷基取代，諸如C(CH 3) 2CN。在其他實施例中，R 2可選地經C 1-6鹵烷基取代，諸如CF 3、CHF 2、CH 2F、CH(CH 3)F、CH 2CF 3、C(CH 3) 2F、C(CH 3)F 2、或CH 2CHF 2。在進一步實施例中，R 2係可選地經OH取代。在仍其他實施例中，R 2可選地經可選地經取代之C 3-8環烷基取代，諸如可選地經取代之環丙基、可選地經取代之環丁基、可選地經取代之環戊基、或可選地經取代之環己基。在進一步實施例中，R 2可選地經可選地經取代之C 3-8環烷基(伸烷基)取代，諸如可選地經取代之環丙基(伸烷基)或可選地經取代之環丁基(伸烷基)。在其他實施例中，R 2可選地經可選地經取代之C 3-8環烯基取代，諸如可選地經取代之環己烯基。在又進一步實施例中，R 2可選地經可選地經取代之芳基取代，諸如可選地經取代之苯基。在進一步實施例中，R 2可選地經可選地經取代之芳基(伸烷基)取代，諸如可選地經取代之苄基。在其他實施例中，R 2可選地經可選地經取代之雜芳基取代，諸如可選地經取代之吡唑基、可選地經取代之咪唑基、可選地經取代之吡啶基、可選地經取代之嘧啶基、或可選地經取代之吡𠯤基。在又其他實施例中，R 2可選地經可選地經取代之雜芳基取代，諸如可選地經取代之吡唑基、可選地經取代之咪唑基、可選地經取代之吡啶基、可選地經取代之嘧啶基、可選地經取代之吡𠯤基、或可選地經取代之嗒𠯤基。在進一步實施例中，R 2可選地經可選地經取代之雜環基取代，諸如可選地經取代之吖呾基、可選地經取代之哌啶基、可選地經取代之哌𠯤基、可選地經取代之吡咯啶基、可選地經取代之 啉基、或可選地經取代之6-氮雜螺[2.5]辛-6-基。在又進一步實施例中，R 2可選地經可選地經取代之 啉基(伸烷基)、可選地經取代之哌啶基(伸烷基)、可選地經取代之哌𠯤基(伸烷基)、或可選地經取代之吖呾基(伸烷基)取代。在仍其他實施例中，R 2可選地經C 1-6羥基烷基取代，諸如C(CH 3) 2OH、CH(CH 3)OH、C(CH 3) 2CH 2OH、CH 2C(CH 3) 2OH、或CH(CH 2CH 3)OH。在又進一步實施例中，R 2可選地經C 1-6鹵烷氧基取代，諸如OCF 3、OCH 2CF 3、或OCH 2CH 2CF 3。在仍進一步實施例中，R 2可選地經C 1-6鹵烷氧基(伸烷基)取代，諸如CH 2OCF 3。在其他實施例中，R 2可選地經C 1-6烷氧基取代，諸如甲氧基或乙氧基。在又其他實施例中，R 2可選地經C 1-6烷氧基(伸烷基)取代，諸如C(CH 3) 2OCH 3、CH 2OCH 3、或(CH 2) 2OCH 3。在進一步實施例中，R 2可選地經C 1-6氘化烷氧基(伸烷基)取代，諸如CH 2OCD 3。在進一步實施例中，R 2可選地經C 1-6烷基羰基取代，諸如C(=O)CH 3或CH 2C(=O)CH 3。在又其他實施例中，R 2可選地經C 3-8環烷基磺醯基取代，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。在其他實施例中，R 2可選地經C 1-6烷基磺醯基取代，諸如甲基磺醯基、乙基磺醯基、或丙基磺醯基。在又其他實施例中，R 2可選地經C 1-6烷基磺醯基(伸烷基)取代，諸如C(CH 3) 2SO 2CH 3。在仍進一步實施例中，R 2可選地經以下取代：(CR vR x) pNR yR z，其中R v、R x、R y、R z、及p在上文定義，諸如NH 2、NH環丙基、NHCH 3、N(CH 3) 2、CH 2N(CH 3) 2、(CH 2) 2N(CH 3) 2、CH 2N(CH 3)(CH 2CH 3)、C(CH 3) 2NH(CH 3)、C(CH 3) 2N(CH 3) 2、CH 2N(CH 3)環丁基、或CH 2N(CH 3)(C(O)O三級丁基)。在一些實施例中，p係0。在其他實施例中，p係1。在進一步實施例中，p係2。在仍其他實施例中，p係3。在一些實施例中，R v及R x獨立地係氫或甲基。在其他實施例中，R y及R z獨立地係氫、甲基、乙基、環丙基、環丁基、C(O)O甲基、C(O)O乙基、C(O)O丙基、或C(O)O三級丁基。在其他實施例中，R 2係C(O)NR y2R z2，其中R y2及R z2在上文中定義，諸如C(O)N(CH 3) 2或C(O)NH環丙基。在又其他實施例中，R y2及R z2獨立地係氫、甲基、或環丙基。在進一步實施例中，R 2經下列中之一或多者取代：甲基、乙基、丙基、異丙基、三級丁基、CH=CH 2、CH=CHC(CH 3) 2OH、CH=CH-環丙基、Br、Cl、F、CN、C(CH 3) 2CN、CF 3、CHF 2、CH 2F、CH(CH 3)F、CH 2CF 3、C(CH 3) 2F、C(CH 3)F 2、CH 2CHF 2、OH、可選地經取代之環丙基、可選地經取代之環丁基、可選地經取代之環戊基、可選地經取代之環己基、可選地經取代之環己烯基、可選地經取代之環丙基(伸烷基)、可選地經取代之環丁基(伸烷基)、可選地經取代之苯基、可選地經取代之苄基、可選地經取代之吡唑基、可選地經取代之咪唑基、可選地經取代之吡啶基、可選地經取代之嘧啶基、可選地經取代之吡𠯤基、可選地經取代之吖呾基、可選地經取代之哌啶基、可選地經取代之哌𠯤基、可選地經取代之吡咯啶基、可選地經取代之 啉基、可選地經取代之6-氮雜螺[2.5]辛-6-基、可選地經取代之 啉基(伸烷基)、可選地經取代之哌啶基(伸烷基)、可選地經取代之哌𠯤基(伸烷基)、或可選地經取代之吖呾基(伸烷基)、C(CH 3) 2OH、CH(CH 3)OH、C(CH 3) 2CH 2OH、CH 2C(CH 3) 2OH、CH(CH 2CH 3)OH、OCH 2CH 2CF 3、OCF 3、OCH 2CF 3、CH 2OCF 3、甲氧基、乙氧基、C(CH 3) 2OCH 3、CH 2OCH 3、(CH 2) 2OCH 3、CH 2OCD 3、C(=O)CH 3、CH 2C(=O)CH 3、環丙基磺醯基、環丁基磺醯基、環戊基磺醯基、C(CH 3) 2SO 2CH 3、NH 2、NH環丙基、NHCH 3、N(CH 3) 2、CH 2N(CH 3) 2、(CH 2) 2N(CH 3) 2、CH 2N(CH 3)(CH 2CH 3)、C(CH 3) 2NH(CH 3)、C(CH 3) 2N(CH 3) 2、CH 2N(CH 3)環丁基、CH 2N(CH 3)(C(O)O三級丁基)、C(O)N(CH 3) 2、或C(O)NH環丙基。
在又進一步實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在其他實施例中，R 2係 或 。在又其他實施例中，R 2係 、 、 、 、 、 、 、或 。
在一些實施例中，R 2係雜環基，其可選地經鹵基、C 1-6鹵烷基、或可選地經取代之雜芳基中之一或多者取代。在仍其他實施例中，R 2係 、 、 、 、或 。在又其他實施例中，R 2係雜環基，其經鹵基、C 1-6鹵烷基、或可選地經取代之雜芳基中之一或多者取代。在進一步實施例中，R 2係 、 、 、或 。在仍進一步實施例中，R 2係 。
在一些實施例中，R 2係C 3-8環烷基，其可選地經鹵基、C 1-6烷基、C 1-6鹵烷基、或OH中之一或多者取代。在其他實施例中，R 2係C 3-8環烷基，其可選地經鹵基或OH中之一或多者取代。在又其他實施例中，R 2係未經取代之環丙基、未經取代之環丁基、未經取代之環戊基、未經取代之環己基、 、 、 、 、 、 、或 。在進一步實施例中，R 2係C 3-8環烷基，其經鹵基、C 1-6烷基、C 1-6鹵烷基、或OH中之一或多者取代。在仍進一步實施例中，R 2係 、 、 、 、 、 、或 。在其他實施例中，R 2係 、 、或 。
在一些實施例中，R 2係芳基，其可選地經鹵基或C 1-6烷氧基中之一或多者取代。在其他實施例中，R 2係未經取代之苯基、 、 、 、 、 、 、或 。在又其他實施例中，R 2係芳基，其經鹵基或C 1-6烷氧基中之一或多者取代。在其他實施例中，R 2係 、 、 、 、 、 、或 。
在一些實施例中，R 2係可選地經取代之吡啶基、可選地經取代之嘧啶基、或可選地經取代之吡𠯤基。在其他實施例中，吡啶基、嘧啶基、或吡𠯤基經鹵基、C 1-6鹵烷基、氰基、或NR yR z中之一或多者取代，其中R y及R z獨立地係H或C 1-6烷基。
在仍進一步實施例中，R 2係雜芳基，其經C 1-6烷基、C 1-6氰烷基、C 1-6鹵烷基、或C 1-6羥基烷基中之一或多者取代。在其他實施例中，R 2係經C 1-6烷基中之一或多者取代之雜芳基。在又其他實施例中，R 2係經C 1-6氰烷基中之一或多者取代之雜芳基。在進一步實施例中，R 2係經C 1-6鹵烷基中之一或多者取代之雜芳基。在仍進一步實施例中，R 2係經C 1-6氟烷基中之一或多者取代之雜芳基。在又其他實施例中，R 2係經C 1-6羥基烷基中之一或多者取代之雜芳基。在其他實施例中，R 2係經下列中之一或多者取代之雜芳基：甲基、乙基、異丙基、三級丁基、C(CH 3) 2CN、CH(CH 3)OH、C(CH 3) 2OH、C(CH 3) 2CH 2OH、CH(CH 2CH 3)OH、CH 2C(CH 3) 2OH、CH 2F、CHF 2、CF 3、CH 2CF 3、CH 2CHF 2、CH(CH 3)F、C(CH 3)F 2、或C(CH 3) 2F。在又其他實施例中，R 2係經下列中之一或多者取代之雜芳基：甲基、異丙基、三級丁基、C(CH 3) 2CN、CH(CH 3)OH、C(CH 3) 2OH、CHF 2、CF 3、CH 2CF 3、CH(CH 3)F、或C(CH 3) 2F。在其他實施例中，R 2係經甲基取代之雜芳基。在又其他實施例中，R 2係經異丙基取代之雜芳基。在其他實施例中，R 2係經三級丁基取代之雜芳基。在又其他實施例中，R 2係經C(CH 3) 2CN取代之雜芳基。在仍進一步實施例中，R 2係經CH(CH 3)OH取代之雜芳基。在其他實施例中，R 2係經C(CH 3) 2OH取代之雜芳基。在進一步實施例中，R 2係經CHF 2取代之雜芳基。在仍其他實施例中，R 2係經CF 3取代之雜芳基。在進一步實施例中，R 2係經CH 2CF 3取代之雜芳基。在仍其他實施例中，R 2係經CH(CH 3)F取代之雜芳基。在其他實施例中，R 2係經C(CH 3) 2F取代之雜芳基。
在其他實施例中，R 2係經C 3-8環烷基取代之雜芳基，其中C 3-8環烷基本身可選地經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、或C 1-6烷氧基中之一或多者取代。在又其他實施例中，R 2係雜芳基，其經未經取代之C 3-8環烷基取代，諸如環丙基、環丁基、環戊基、或環己基。在進一步實施例中，R 2係經環丙基或環丁基取代之雜芳基。在又其他實施例中，R 2係雜芳基，其經C 3-8環烷基取代，諸如環丙基、環丁基、環戊基、或環己基，其中C 3-8環烷基本身經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、或C 1-6烷氧基中之一或多者取代。在一些實施例中，經取代之C 3-8環烷基經OH取代。在仍進一步實施例中，經取代之C 3-8環烷基經一或多個鹵基取代，諸如F、Cl、或Br。在其他實施例中，經取代之C 3-8環烷基經C 1-6烷基取代，諸如甲基、乙基、或丙基。在進一步實施例中，經取代之C 3-8環烷基經C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在仍其他實施例中，經取代之C 3-8環烷基經C 1-6烷氧基取代，諸如甲氧基、乙氧基、或丙氧基。在進一步實施例中，經取代之C 3-8環烷基係環丙基或環丁基，其中之各者經F、OH、或甲基中之一或多者取代。在其他實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、或 取代。在仍其他實施例中，R 2係雜芳基，其經 、 、 、 、 、 、或 取代。
在其他實施例中，R 2係經芳基取代之雜芳基，其中芳基本身可選地經鹵基、C 1-6鹵烷基、C 1-6烷基、或C 3-8環烷基中之一或多者取代。在又其他實施例中，R 2係經未經取代之苯基取代之雜芳基。在進一步實施例中，R 2係經芳基（諸如苯基）取代之雜芳基，其中芳基本身經鹵基、C 1-6鹵烷基、C 1-6烷基、或C 3-8環烷基中之一或多者取代。在一些實施例中，經取代之芳基經一或多個鹵基取代，諸如F、Cl、或Br。在又其他實施例中，經取代之芳基經C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在仍進一步實施例中，經取代之芳基經C 1-6烷基取代，諸如甲基、乙基、或丙基。在其他實施例中，經取代之芳基經C 3-8環烷基取代，諸如環丙基、環丁基、或環戊基。在又其他實施例中，經取代之芳基係苯基，其經F、甲基、或CF 3中之一或多者取代。在進一步實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、或 取代。在仍進一步實施例中，R 2係雜芳基，其經 、 、 、 、 、 、或 取代。
在仍進一步實施例中，R 2係經可選地經取代之雜芳基取代之雜芳基。在一些實施例中，可選地經取代之雜芳基係可選地經取代之吡啶基、可選地經取代之吡𠯤基、可選地經取代之吡唑基、可選地經取代之咪唑基、或可選地經取代之嘧啶基。在又其他實施例中，雜芳基上之可選取代係鹵基、C 1-6鹵烷基、C 1-6烷基、C 1-6烷氧基、C 1-6鹵烷氧基、C 3-8環烷基、或C 3-8環烷基磺醯基中之一或多者。在其他實施例中，可選地經取代之雜芳基經一或多個鹵基取代，諸如F、Cl、或Br。在仍其他實施例中，可選地經取代之雜芳基經一或多個C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、CH 2CHF 2、或CHF 2。在其他實施例中，可選地經取代之雜芳基經一或多個C 1-6烷基取代，諸如甲基、乙基、丙基、或異丙基。在仍其他實施例中，可選地經取代之雜芳基經一或多個C 1-6烷氧基取代，諸如甲氧基、乙氧基、或丙氧基。在其他實施例中，可選地經取代之雜芳基經一或多個C 1-6鹵烷氧基取代，諸如OCF 3。在又其他實施例中，可選地經取代之雜芳基經一或多個C 3-8環烷基取代，諸如環丙基、環丁基、或環戊基。在其他實施例中，可選地經取代之雜芳基經一或多個C 3-8環烷基磺醯基取代，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。在仍其他實施例中，可選地經取代之雜芳基經F、CF 3、CH 2CHF 2、CHF 2、甲基、甲氧基、環丁基、或環丙基磺醯基中之一或多者取代。
在又其他實施例中，R 2係雜芳基，其經吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、嘧啶-2-基、嘧啶-4-基、嘧啶-5-基、吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、吡𠯤-5-基、咪唑-4-基、或咪唑-5-基取代，其中之各者可以可選地經取代。在進一步實施例中，R 2經吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、嘧啶-2-基、嘧啶-4-基、嘧啶-5-基、吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、吡𠯤-5-基、咪唑-4-基、咪唑-5-基、嗒𠯤-3-基、嗒𠯤-4-基取代，其中之各者可選地經取代。在仍進一步實施例中，R 2經可選地經取代之吡唑-1-基取代。在其他實施例中，R 2經可選地經取代之吡唑-3-基取代。在進一步實施例中，R 2經可選地經取代之吡唑-4-基取代。在又進一步實施例中，R 2經可選地經取代之吡啶-2-基取代。在其他實施例中，R 2經可選地經取代之吡啶-3-基取代。在進一步實施例中，R 2經可選地經取代之吡啶-4-基取代。在進一步實施例中，R 2經可選地經取代之咪唑-4-基取代。在又其他實施例中，R 2經可選地經取代之咪唑-5-基取代。在進一步實施例中，R 2經可選地經取代之嘧啶-2-基取代。在其他實施例中，R 2經可選地經取代之嘧啶-4-基取代。在仍進一步實施例中，R 2經可選地經取代之嘧啶-5-基取代。在又其他實施例中，R 2經可選地經取代之吡𠯤-2-基取代。在其他實施例中，R 2經可選地經取代之嗒𠯤-3-基取代。在進一步實施例中，R 2經可選地經取代之嗒𠯤-4-基取代。
在一些實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。在仍進一步實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。在仍進一步實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。
在一些實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。在其他實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。在仍其他實施例中，R 2係雜芳基，其經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。
在其他實施例中，R 2係雜芳基，其經雜環基或雜環基(伸烷基)取代，其中該雜環基及雜環基(伸烷基)本身各自可選地經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、C 1-6羥基烷基、C 1-6烷氧基、C(O)O(C 1-6烷基)、或C 3-8環烷基中之一或多者取代。在又其他實施例中，R 2係經以下取代之雜芳基：未經取代之雜環基，諸如吖呾基、吡咯啶基、哌啶基、哌𠯤基、 啉基、或6-氮雜螺[2.5]辛-6-基；或未經取代之雜環基(伸烷基)，諸如吖呾基(伸烷基)、吡咯啶基(伸烷基)、哌啶基(伸烷基)、哌𠯤基(伸烷基)、或 啉基(伸烷基)。在進一步實施例中，R 2係經以下取代之雜芳基：雜環基，諸如吖呾基、吡咯啶基、哌啶基、哌𠯤基、或 啉基；或雜環基(伸烷基)，諸如吖呾基(伸烷基)、吡咯啶基(伸烷基)、哌啶基(伸烷基)、哌𠯤基(伸烷基)、或 啉基(伸烷基)，其中該雜環基及雜環基(伸烷基)本身各自經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、C 1-6羥基烷基、C 1-6烷氧基、C(O)O(C 1-6烷基)、或C 3-8環烷基中之一或多者取代。在進一步實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經一或多個鹵基取代，諸如F、Cl、或Br。在又進一步實施例中，經取代之雜環基或經取代雜環基(伸烷基)經一或多個OH取代。在又其他實施例中，經取代之雜環基或經取代雜環基(伸烷基)經一或多個C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在仍進一步實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經一或多個C 1-6烷基取代，諸如甲基、乙基、或丙基。在又進一步實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經一或多個C 1-6羥基烷基取代，諸如C(CH 3) 2OH或CH(CH 3)OH。在其他實施例中，經取代之雜環基或經取代雜環基(伸烷基)經一或多個C 1-6烷氧基取代，諸如甲氧基、乙氧基、或丙氧基。在又其他實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經一或多個C(O)O(C 1-6烷基)取代，諸如C(O)O甲基、C(O)O乙基、C(O)O丙基、或C(O)O三級丁基。在進一步實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經一或多個C 3-8環烷基取代，諸如環丙基、環丁基、或環戊基。在又其他實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經F、OH、或甲基中之一或多者取代。在其中R 2係雜芳基之又其他實施例中，R 2經以下取代： 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在其中R 2係雜芳基之仍進一步實施例中，R 2經以下取代： 、 、 、 、 、 、或 。
在進一步實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在又進一步實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、或 。在仍進一步實施例中，R 2係 、 、 、 、 、 、或 。在其他實施例中，R 2係 或 。在進一步實施例中，R 2係 、 、 、或 。在又進一步實施例中，R 2係 或 。在仍進一步實施例中，R 2係 、 、 、或 。在又其他實施例中，R 2係 。在其他實施例中，R 2係 。在進一步實施例中，R 2係 。在又其他實施例中，R 2係 。在仍進一步實施例中，R 2係 。在其他實施例中，R 2係 。在進一步實施例中，R 2係 。在仍其他實施例中，R 2係 。在又進一步實施例中，R 2係 。在其他實施例中，R 2係 。在進一步實施例中，R 2係 。在又其他實施例中，R 2係 。在仍進一步實施例中，R 2係 。在其他實施例中，R 2係 。在其他實施例中，R 2係 。在進一步實施例中，R 2係 。在又其他實施例中，R 2係 。
在R 2之此等結構中，R 6及R 7各自獨立地係H、CN、C 1-6烷基、C 1-6鹵烷基、C 1-6氰烷基、C 1-6羥基烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 1-6氘化烷氧基(伸烷基)、鹵基、(CR vR x) pNR yR z、C(O)NR y2R z2、C 1-6烷基羰基、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、可選地經取代之雜芳基、可選地經取代之C 2-6烯基、可選地經取代之C 3-8環烯基、可選地經取代之(C 3-8環烷基)伸烷基、可選地經取代之(芳基)伸烷基、可選地經取代之(雜環基)伸烷基、或C 1-6烷基磺醯基；R 8係H、C 1-6烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、C 1-6烷基羰基、C 1-6羥基烷基、(CR vR x) pNR yR z、可選地經取代之C 3-8環烷基、可選地經取代之芳基、可選地經取代之雜芳基、或可選地經取代之C 3-8環烷基)伸烷基；R v及R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 1-6烷氧基(伸烷基)、或C 3-6環烷基；R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基；且p係0、1、2、或3。在一些實施例中，R 6、R 7、及R 8係H。
在其他實施例中，R 6係C 1-6烷基、C 1-6鹵烷基、C 1-6氰烷基、或C 1-6羥基烷基。在進一步實施例中，R 6係C 1-6烷基，諸如甲基、乙基、異丙基、或三級丁基。在仍進一步實施例中，R 6係C 1-6鹵烷基，諸如CF 3、CHF 2、CH 2F、CH 2CF 3、CH(CH 3)F、C(CH 3)F 2、或C(CH 3) 2F。在進一步實施例中，R 6係C 1-6氰烷基，諸如C(CH 3) 2CN。在其他實施例中，R 6係C 1-6羥基烷基，諸如C(CH 3) 2OH、CH(CH 3)OH、CH(CH 2CH 3)OH、CH 2C(CH 3) 2OH、或C(CH 3) 2CH 2OH。在進一步實施例中，R 6係甲基、異丙基、三級丁基、CF 3、CHF 2、C(CH 3)F 2、C(CH 3) 2F、C(CH 3) 2OH、或CH(CH 3)OH。
在其他實施例中，R 6係C 3-6環烷基，其可選地經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、或C 1-6烷氧基中之一或多者取代。在進一步實施例中，R 6係環丙基、環丁基、環戊基、或環己基，其可選地經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、或C 1-6烷氧基中之一或多者取代。在仍進一步實施例中，R 6係未經取代之環丙基、環丁基、環戊基、或環己基。在其他實施例中，R 6係C 3-6環烷基，其經一或多個鹵基取代，諸如F、Cl、或Br。在又其他實施例中，R 6係經一或多個OH取代之C 3-6環烷基。在仍進一步實施例中，R 6係C 3-6環烷基，其經一或多個C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在進一步實施例中，R 6係C 3-6環烷基，其經一或多個C 1-6烷基取代，諸如甲基、乙基、或丙基。在仍進一步實施例中，R 6係C 3-6環烷基，其經C 1-6烷氧基取代，諸如一或多個甲氧基、乙氧基、或丙氧基。在其他實施例中，R 6係環丙基、環丁基、或環己基，其中之各者可選地經F、OH、或甲基中之一或多者取代。在其他實施例中，R 6係 、 、 、 、 、 、 、或 。在其他實施例中，R 6係 、 、 、 、 、 、或 。
在進一步實施例中，R 6係芳基，其可選地經鹵基、C 1-6鹵烷基、C 1-6烷基、或C 3-6環烷基中之一或多者取代。在其他實施例中，R 6係苯基，其可選地經鹵基、C 1-6鹵烷基、C 1-6烷基、或C 3-6環烷基中之一或多者取代。在仍其他實施例中，R 6係芳基，其可選地經一或多個鹵基取代，諸如F、Cl、或Br。在又其他實施例中，R 6係芳基，其可選地經一或多個C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在其他實施例中，R 6係芳基，其可選地經一或多個C 1-6烷基取代，諸如甲基、乙基、或丙基。在又其他實施例中，R 6係芳基，其可選地經一或多個C 3-6環烷基取代，諸如環丙基、環丁基、或環戊基。在其他實施例中，R 6係芳基（例如苯基），其可選地經F、甲基、或CF 3取代。在其他實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 6係 、 、 、 、 、 、或 。
在又其他實施例中，R 6係雜芳基，其可選地經鹵基、C 1-6鹵烷基、C 1-6烷基、C 1-6烷氧基、C 1-6鹵烷氧基、C 3-6環烷基、或C 3-6環烷基磺醯基中之一或多者取代。在仍其他實施例中，R 6係吡啶基、吡唑基、吡𠯤基、咪唑基、或嘧啶基，其中之各者可選地經取代。在仍其他實施例中，R 6係吡啶基、吡唑基、吡𠯤基、嗒𠯤基、咪唑基、或嘧啶基，其中之各者可選地經取代。在進一步實施例中，R 6係可選地經取代之吡𠯤基，諸如吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、或吡𠯤-5-基。在其他實施例中，R 6係可選地經取代之吡唑基，諸如吡唑-1-基、吡唑-3-基、吡唑-4-基、或吡唑-5-基。在仍進一步實施例中，R 6係可選地經取代之吡啶基，諸如吡啶-2-基、吡啶-3-基、或吡啶-4-基。在其他實施例中，R 6係可選地經取代之嗒𠯤基，諸如嗒𠯤-3-基或嗒𠯤-4-基。在又其他實施例中，R 6係可選地經取代之咪唑基，諸如咪唑-4-基或咪唑-5-基。在進一步實施例中，R 6係可選地經取代之嘧啶基，諸如嘧啶-2-基、嘧啶-4-基、或嘧啶-5-基。在其他實施例中，R 6係吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、吡𠯤-5-基、吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、咪唑-4-基、咪唑-5-基、嘧啶-2-基、嘧啶-4-基、或嘧啶-5-基，其中之各者可選地經取代。在又其他實施例中，R 6係吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、吡𠯤-5-基、吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、咪唑-4-基、咪唑-5-基、嘧啶-2-基、嘧啶-4-基、嘧啶-5-基、嗒𠯤-3-基或嗒𠯤-4-基，其中之各者可選地經取代。在進一步實施例中，R 6係未經取代之吡啶-2-基、未經取代之吡啶-3-基、未經取代之吡啶-4-基、未經取代之嘧啶-2-基、未經取代之嘧啶-4-基、未經取代之嘧啶-5-基、或未經取代之吡𠯤-2-基。在進一步實施例中，R 6係未經取代之吡啶-2-基、未經取代之吡啶-3-基、未經取代之吡啶-4-基、未經取代之嘧啶-2-基、未經取代之嘧啶-4-基、未經取代之嘧啶-5-基、未經取代之吡𠯤-2-基、或嗒𠯤-3-基。在其他實施例中，R 6可選地經一或多個鹵基取代，諸如F、Cl、或Br。在又其他實施例中，R 6可選地經一或多個C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在其他實施例中，R 6可選地經一或多個C 1-6烷基取代，諸如甲基、乙基、丙基、或異丙基。在仍其他實施例中，R 6可選地經一或多個C 1-6烷氧基取代，諸如甲氧基、乙氧基、或丙氧基。在又進一步實施例中，R 6可選地經一或多個C 1-6鹵烷氧基取代，諸如OCF 3。在進一步實施例中，R 6可選地經一或多個C 3-6環烷基取代，諸如環丙基、環丁基、或環戊基。在又進一步實施例中，R 6可選地經一或多個C 3-6環烷基磺醯基取代，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。在又其他實施例中，R 6係雜芳基，其可選地經F、CF 3、CH 2CF 3、CHF 2、甲基、甲氧基、OCF 3、環丁基、或環丙基磺醯基中之一或多者取代。
在其他實施例中，R 6係五員雜芳基，其可選地經CF 3、CH 2CF 3、CHF 2、甲基、環丁基、或環丙基磺醯基中之一或多者取代。在進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在仍進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在其他實施例中，R 6係 、 、 、 、或 。在仍進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在又進一步實施例中，R 6係 或 。在進一步實施例中，R 6係 或 。在又進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
在其他實施例中，R 6係六員雜芳基，其可選地經F、CF 3、甲氧基、OCF 3、或甲基中之一或多者取代。在仍其他實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在仍進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
在又其他實施例中，R 6係雜環基或雜環基(伸烷基)，其各自可選地經鹵基、OH、C 1-6鹵烷基、C 1-6烷基、C 1-6羥基烷基、C 1-6烷氧基、C(O)O(C 1-6烷基)、或C 3-6環烷基中之一或多者取代。在進一步實施例中，R 6係可選地經取代之吖呾基、可選地經取代之吡咯啶基、可選地經取代之哌啶基、可選地經取代之哌𠯤基、或可選地經取代之 啉基。在其他實施例中，R 6係可選地經取代之吖呾基。在又其他實施例中，R 6係可選地經取代之吡咯啶基。在進一步實施例中，R 6係可選地經取代之哌啶基。在又其他實施例中，R 6係可選地經取代之哌𠯤基。在仍進一步實施例中，R 6係可選地經取代之 啉基。在其他實施例中，R 6係可選地經取代之 啉基(伸烷基)、可選地經取代之哌啶基(伸烷基)、可選地經取代之哌𠯤基(伸烷基)、或可選地經取代之吖呾基(伸烷基)。在進一步實施例中，R 6係未經取代之吖呾基、吡咯啶基、哌啶基、哌𠯤基、或 啉基。在其他實施例中，R 6係未經取代之 啉基(伸烷基)、哌啶基(伸烷基)、哌𠯤基(伸烷基)、或吖呾基(伸烷基)。在又其他實施例中，R 6係未經取代之 啉基或 啉基(伸烷基)。在其他實施例中，雜環基及雜環基(伸烷基)可選地經一或多個鹵基取代，諸如F、Cl、或Br。在又其他實施例中，雜環基及雜環基(伸烷基)可選地經一或多個OH取代。在進一步實施例中，雜環基及雜環基(伸烷基)可選地經一或多個C 1-6鹵烷基取代，諸如CF 3、CH 2CF 3、或CHF 2。在仍進一步實施例中，雜環基及雜環基(伸烷基)可選地經一或多個C 1-6烷基取代，諸如甲基、乙基、或丙基。在進一步實施例中，雜環基及雜環基(伸烷基)可選地經一或多個C 1-6羥基烷基取代，諸如C(CH 3) 2OH。在又進一步實施例中，雜環基及雜環基(伸烷基)可選地經一或多個C 1-6烷氧基取代，諸如甲氧基、乙氧基、或丙氧基。在其他實施例中，雜環基及雜環基(伸烷基)可選地經一或多個C(O)O(C 1-6烷基)取代，諸如C(O)O甲基、C(O)O乙基、C(O)O丙基、或C(O)O三級丁基。在仍進一步實施例中，雜環基及雜環基(伸烷基)可選地經一或多個C 3-6環烷基取代，諸如一或多個環丙基、環丁基、或環戊基。在又其他實施例中，R 6係雜環基及雜環基(伸烷基)，其各自可選地經F、OH、C(CH 3) 2(OH)、甲基、C(O)O(三級丁基)、或環丙基中之一或多者取代。
在進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 6係 、 、 、或 。在進一步實施例中，R 6係 、 、或 。在仍進一步實施例中，R 6係 、 、或 。在又其他實施例中，R 6係 、 、或 。在其他實施例中，R 6係 、 、 、或 。在又進一步實施例中，R 6係 或 。
在進一步實施例中，R 6係H、CN、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 1-6氘化烷氧基(伸烷基)、鹵基、(CR vR x) pNR yR z、C(O)NR y2R z2、C 1-6烷基羰基、可選地經取代之C 2-6烯基、可選地經取代之C 3-6環烯基、可選地經取代之(C 3-6環烷基)伸烷基、可選地經取代之(芳基)伸烷基、或C 1-6烷基磺醯基。在其他實施例中，R 6係H。在進一步實施例中，R 6係CN。在仍其他實施例中，R 6係C 1-6烷氧基，諸如甲氧基。在又其他實施例中，R 6係C 1-6烷氧基(伸烷基)，諸如CH 2OCH 3、C(CH 3) 2OCH 3、或(CH 2) 2OCH 3。在仍其他實施例中，R 6係C 1-6鹵烷氧基，諸如OCF 3、OCHF 2、OCH 2F、或O(CH 2) 2CF 3。在其他實施例中，R 6係C 1-6鹵烷氧基(伸烷基)，諸如CH 2OCF 3。在又其他實施例中，R 6係C 1-6氘化烷氧基(伸烷基)，諸如CH 2OCD 3。在進一步實施例中，R 6係鹵基，諸如F、Br、或Cl。在又進一步實施例中，R 6係(CR vR x) pNR yR z，諸如NH 2、N(CH 3) 2、NHCH 2CF 3、NHCH 2CH 2OCH 3、NH(環丙基)、CH 2N(CH 3) 2、(CH 2) 2N(CH 3) 2、C(CH 3) 2NHCH 3、C(CH 3) 2N(CH 3) 2、CH 2NH(環丙基)、或CH 2CH 2NH(環丙基)。在其他實施例中，R 6係C(O)NR y2R z2，諸如C(O)N(CH 3) 2或C(O)NH(環丙基)。在又其他實施例中，R 6係C 1-6烷基羰基，諸如C(O)CH 3。在進一步實施例中，R 6係可選地經取代之C 2-6烯基，諸如CH=CH 2、CH=CH-環丙基、或CH=CHC(CH 3) 2OH。在又其他實施例中，R 6係可選地經取代之C 3-6環烯基，諸如 。在仍其他實施例中，R 6係可選地經取代之(C 3-6環烷基)伸烷基，諸如CH 2-環丙基、CH 2CH 2-環丙基、或C(CH 3)OH-環丙基。在進一步實施例中，R 6係可選地經取代之(芳基)伸烷基，諸如苄基。在其他實施例中，C 1-6烷基磺醯基(伸烷基)，諸如C(CH 3) 2SO 2CH 3。在又其他實施例中，R 6係H、CH 2OCH 3、Cl、NH(環丙基)、或C(O)N(CH 3) 2。
在一些實施例中，R 7係H、CN、C 1-6烷基、C 1-6鹵烷基、鹵基、C 3-8環烷基、芳基、或雜芳基。在又其他實施例中，R 7係H。在仍進一步實施例中，R 7係CN。在其他實施例中，R 7係C 1-6烷基，諸如甲基、乙基、或丙基。在進一步實施例中，R 7係甲基。在又其他實施例中，R 7係C 1-6鹵烷基，諸如CHF 2、CH 2F、C(CH 3)F 2、CH 2CHF 2、或CF 3。在仍進一步實施例中，R 7係CHF 2或CF 3。在進一步實施例中，R 7係鹵基，諸如F、Br、或Cl。在又其他實施例中，R 7係Br或Cl。在仍進一步實施例中，R 7係C 3-6環烷基，諸如環丙基、環丁基、或環戊基。在其他實施例中，R 7係環丙基。在進一步實施例中，R 7係芳基。在又其他實施例中，R 7係苯基。在仍進一步實施例中，R 7係雜芳基。在其他實施例中，R 7係吡啶基。在進一步實施例中，R 7係H、CN、甲基、CF 3、CH 2F、CHF 2、CF 2(CH 3)、CH 2CHF 2、Br、Cl、環丙基、苯基、或吡啶基。在又其他實施例中，R 7係H、CN、甲基、CHF 2、CF 3、Br、Cl、環丙基、苯基、或吡啶基。
在R 2之一些實施例中，R 8係H。在其他實施例中，R 8係C 1-6烷基，諸如甲基、乙基、異丙基、或三級丁基。在進一步實施例中，R 8係C 1-6鹵烷基，諸如CF 3、CHF 2、CH 2F、CH 2CF 3、CH 2CHF 2、C(CH 3) 2F、或C(CH 3)F 2。在仍進一步實施例中，R 8係C 1-6烷氧基(伸烷基)，諸如CH 2CH 2OCH 3。在其他實施例中，R 8係C 1-6烷基羰基，諸如CH 2C(=O)CH 3。在仍其他實施例中，R 8係C 1-6羥基烷基，諸如CH 2C(CH 3) 2OH。在進一步實施例中，R 8係(CR vR x) pNR yR z，諸如(CH 2) 2N(CH 3) 2。在又其他實施例中，R 8係可選地經取代之C 3-8環烷基，諸如可選地經取代之環丙基、可選地經取代之環丁基、可選地經取代之環戊基、或可選地經取代之環己基。在其他實施例中，R 8係可選地經取代之芳基，諸如可選地經取代之苯基。在進一步實施例中，R 8係可選地經取代之雜芳基，諸如可選地經取代之吡啶基。在仍進一步實施例中，R 8係可選地經取代之雜芳基，諸如可選地經取代之吡啶基。在又其他實施例中，R 8係可選地經取代之(C 3-8環烷基)伸烷基，諸如 。在仍進一步實施例中，R 8係H、甲基、異丙基、CHF 2、CH 2CF 3、CF 3、環丙基、或 。
在一些實施例中，R v及R x中之一或兩者係H。在其他實施例中，R v及R x中之一或兩者係C 1-6烷基，諸如甲基、乙基、丙基、或丁基。在又其他實施例中，R v及R x中之一或兩者係甲基。在一些實施例中，R y及R z中之一或兩者係H。在其他實施例中，R y及R z中之一或兩者係C 1-6烷基，諸如甲基、乙基、丙基、或丁基。在又其他實施例中，R y及R z中之一或兩者係C 1-6烷氧基(伸烷基)，諸如CH 2OCH 3。在進一步實施例中，R y及R z中之一或兩者係C 3-6環烷基，諸如環丙基、環丁基、環戊基、或環己基。在一些實施例中，R y2及R z2中之一或兩者係H。在其他實施例中，R y2及R z2中之一或兩者係C 1-6烷基，諸如甲基、乙基、丙基、或丁基。在進一步實施例中，R y2及R z2中之一或兩者係C 3-6環烷基，諸如環丙基、環丁基、環戊基、或環己基。在進一步實施例中，p係0。在其他實施例中，p係1。在仍進一步實施例中，p係2。在又其他實施例中，p係3。
在一些實施例中，R 2係 ，其中：R 6係H、C 1-6烷基、C 1-6鹵烷基、C 1-6氰烷基、C 1-6羥基烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、可選地經取代之C 3-6環烷基、或可選地經取代之雜芳基；且R 7係H、CN、C 1-6烷基、C 1-6鹵烷基、鹵基、C 3-6環烷基、芳基、或雜芳基。在進一步實施例中，R 6係H、C 1-6烷基、C 1-6鹵烷基、C 1-6氰烷基、C 1-6羥基烷基、可選地經取代之C 3-6環烷基、或可選地經取代之雜芳基；且R 7係H、CN、C 1-6烷基、C 1-6鹵烷基、鹵基、或C 3-6環烷基。在其他實施例中，R 6係H。在進一步實施例中，R 6係C 1-6烷基。在仍進一步實施例中，R 6係甲基、異丙基、或三級丁基。在又其他實施例中，R 6係C 1-6鹵烷基。在仍進一步實施例中，R 6係CF 2H、C(CH 3) 2F、CH(CH 3)F、或CF 3。在其他實施例中，R 6係C 1-6氰烷基。在進一步實施例中，R 6係C(CH 3) 2CN。在又其他實施例中，R 6係C 1-6羥基烷基。在仍進一步實施例中，R 6係C(CH 3) 2OH、CH 2C(CH 3) 2OH、CH(CH 2CH 3)OH、C(CH 3) 2(CH 2OH)、或CH(CH 3)OH。在其他實施例中，R 6係C 1-6烷氧基。在仍其他實施例中，R 6係甲氧基或乙氧基。在又其他實施例中，R 6係C 1-6烷氧基(伸烷基)。在進一步實施例中，R 6係CH 2OCH 3或(CH 2) 2OCH 3。在其他實施例中，R 6係可選地經取代之C 3-6環烷基。在又其他實施例中，可選地經取代之C 3-6環烷基經一或多個OH取代。在進一步實施例中，R 6係 、 、 、 、 、或 。在又其他實施例中，R 6係 或 。在其他實施例中，R 6係可選地經取代之雜芳基。在又其他實施例中，R 6係可選地經取代之吡啶基、可選地經取代之吡唑基、可選地經取代之吡𠯤基、可選地經取代之嘧啶基、或可選地經取代之咪唑基。在仍其他實施例中，可選地經取代之雜芳基經一或多個C 1-6烷基取代，諸如甲基、乙基、或異丙基。在進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在仍進一步實施例中，R 6係 、 、 、 、 、 、或 。在其他實施例中，R 6係H、甲基、三級丁基、C(CH 3) 2F、C(CH 3) 2CN、C(CH 3) 2OH、CH(CH 3)OH、CH 2OCH 3、環丙基、 、 、 、 、 、 、 、或 。在進一步實施例中，R 6係H、三級丁基、C(CH 3) 2F、C(CH 3) 2CN、C(CH 3) 2OH、CH(CH 3)OH、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 7係H。在仍進一步實施例中，R 7係CN。在其他實施例中，R 7係C 1-6烷基。在進一步實施例中，R 7係甲基。在又其他實施例中，R 7係C 1-6鹵烷基。在仍進一步實施例中，R 7係CF 2H、CHF 2、CH 2F、C(CH 3)F 2、或CF 3。在其他實施例中，R 7係CHF 2或CF 3。在進一步實施例中，R 7係鹵基。在又其他實施例中，R 7係Br或Cl。在仍進一步實施例中，R 7係C 3-6環烷基。在其他實施例中，R 7係環丙基。在進一步實施例中，R 7係芳基。在又其他實施例中，R 7係苯基。在仍進一步實施例中，R 7係雜芳基。在其他實施例中，R 7係吡啶基。在又其他實施例中，R 7係H、CN、甲基、CHF 2、CF 3、Br、Cl、環丙基、苯基、或吡啶基。在仍其他實施例中，R 7係H、CN、甲基、CHF 2、CF 3、Br、Cl、或環丙基。
在其他實施例中，R 2係 ，其中：R 6係H、CN、C 1-6烷基、C 1-6鹵烷基、C 1-6羥基烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、可選地經取代之C 3-6環烷基、可選地經取代之雜芳基；且R 7係H、C 1-6烷基、C 1-6鹵烷基、鹵基、或C 3-6環烷基。在又其他實施例中，R 6係H、C 1-6烷基、C 1-6鹵烷基、或C 1-6羥基烷基；且R 7係H。在進一步實施例中，R 6係H。在其他實施例中，R 6係CN。在進一步實施例中，R 6係C 1-6烷基。在仍進一步實施例中，R 6係甲基、異丙基、或三級丁基。在又其他實施例中，R 6係C 1-6鹵烷基。在仍進一步實施例中，R 6係CHF 2、C(CH 3) 2F、C(CH 3)F 2、或CF 3。在又其他實施例中，R 6係C 1-6羥基烷基。在仍進一步實施例中，R 6係C(CH 3) 2OH。在其他實施例中，R 6係C 1-6烷氧基。在仍進一步實施例中，R 6係甲氧基或乙氧基。在又其他實施例中，R 6係C 1-6烷氧基(伸烷基)。在進一步實施例中，R 6係CH 2OCH 3。在其他實施例中，R 6係可選地經取代之C 3-6環烷基。在又進一步實施例中，R 6係 、 、 、 、 、 、或 。在其他實施例中，R 6係可選地經取代之雜芳基。在又其他實施例中，R 6係可選地經取代之吡啶基或可選地經取代之吡唑基。在進一步實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在進一步實施例中，R 6係H、三級丁基、C(CH 3) 2F、C(CH 3)F 2、C(CH 3) 2OH、CH 2OCH 3、 、 、 、 、或 。在進一步實施例中，R 6係H或C(CH 3) 2F。在又其他實施例中，R 7係H。在其他實施例中，R 7係C 1-6烷基。在進一步實施例中，R 7係甲基。在又其他實施例中，R 7係C 1-6鹵烷基。在仍進一步實施例中，R 7係CF 2H或CF 3。在進一步實施例中，R 7係鹵基。在又其他實施例中，R 7係Br或Cl。在仍進一步實施例中，R 7係C 3-6環烷基。在其他實施例中，R 7係環丙基。在仍進一步實施例R 7係H、甲基、CF 2H、CF 3、Br、Cl、或環丙基。
在進一步實施例中，R 2係 ，其中R 6及R 7獨立地係H、C 1-6烷基、C 1-6鹵烷基、鹵基、可選地經取代之C 3-6環烷基、或可選地經取代之芳基。在其他實施例中，R 6及R 7各自係H。在進一步實施例中，R 6或R 7中之一者係C 1-6烷基，諸如甲基。在又其他實施例中，R 6或R 7中之一者係C 1-6鹵烷基，諸如CF 3。在仍其他實施例中，R 6或R 7中之一者係鹵基，諸如Br或Cl。在又進一步實施例中，R 6或R 7中之一者係可選地經取代之C 3-6環烷基，諸如未經取代之環丙基。在其他實施例中，R 6或R 7中之一者係可選地經取代之芳基，諸如未經取代之苯基。在又其他實施例中，R 6係甲基、CF 3、Cl、環丙基、或苯基，且R 7係H。在仍其他實施例中，R 7係甲基、CF 3、Cl、環丙基、或苯基，且R 6係H。
在又進一步實施例中，R 2係 ，其中R 6係H、C 1-6烷基、鹵基、或可選地經取代之芳基。在其他實施例中，R 6係H。在進一步實施例中，R 6係C 1-6烷基，諸如甲基、乙基、異丙基、或三級丁基。在其他實施例中，R 6係甲基或乙基。在其他實施例中，R 6係鹵基，諸如F、Br、或Cl。在進一步實施例中，R 6係Br。在其他實施例中，R 6係可選地經取代之芳基。在進一步實施例中，R 6係苯基。在又其他實施例中，R 6係H、甲基、乙基、Br、或苯基。在仍其他實施例中，R 6係H、甲基、或苯基。
在又其他實施例中，R 2係 ，其中R 6係H、C 1-6烷基、C 1-6鹵烷基、C 1-6羥基烷基、C(O)NR y2R z2、(CR vR x) pNR yR z、可選地經取代之C 3-6環烷基、可選地經取代之芳基、可選地經取代之雜環基、或可選地經取代之雜芳基；R v及R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 1-6烷氧基(伸烷基)、或C 3-6環烷基；R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基；且p係0、1、2、或3。在進一步實施例中，R 6係H、C 1-6烷基、C 1-6鹵烷基、C 1-6羥基烷基、可選地經取代之C 3-6環烷基、可選地經取代之芳基、可選地經取代之雜環基、或可選地經取代之雜芳基。在一些實施例中，R 6係H。在進一步實施例中，R 6係C 1-6烷基。在其他實施例中，R 6係甲基、乙基、異丙基、或三級丁基。在進一步實施例中，R 6係甲基、異丙基、或三級丁基。在其他實施例中，R 6係C 1-6鹵烷基。在進一步實施例中，R 6係CHF 2、CF 3、或C(CH 3) 2F。在仍進一步實施例中，R 6係CF 3、CHF 2、C(CH 3)F 2、或C(CH 3) 2F。在又其他實施例中，R 6係C 1-6羥基烷基。在仍進一步實施例中，R 6係C(CH 3) 2OH或CH(CH 3)OH。在仍其他實施例中，R 6係C(O)NR y2R z2。在又進一步實施例中，R 6係C(O)N(CH 3) 2或C(O)NH(環丙基)。在其他實施例中，R 6係(CR vR x) pNR yR z。在進一步實施例中，R 6係NH 2、N(CH 3) 2、NHCH 2CF 3、NHCH 2CH 2OCH 3、NH(環丙基)、CH 2N(CH 3) 2、CH 2NH(環丙基)、或CH 2CH 2NH(環丙基)。在又其他實施例中，R 6係可選地經取代之C 3-6環烷基。在仍其他實施例中，可選地經取代之C 3-6環烷基經鹵基（諸如F）或C 1-6烷基（諸如甲基）中之一或多者取代。在仍進一步實施例中，R 6係 、 、 、或 。在其他實施例中，R 6係可選地經取代之芳基。在又其他實施例中，可選地經取代之芳基經鹵基（諸如F）、C 1-6烷基（諸如甲基）、或C 1-6鹵烷基（諸如CF 3）中之一或多者取代。在進一步實施例中，R 6係 、 、 、 、 、 、 、 、或 。在仍其他實施例中，R 6係可選地經取代之雜環基。在進一步實施例中，可選地經取代之雜環基經鹵基（諸如F）或C 1-6烷基（諸如甲基）中之一或多者取代。在又進一步實施例中，R 6係 、 、 、 、或 。在又其他實施例中，R 6係 或 。在其他實施例中，R 6係可選地經取代之雜芳基，諸如可選地經取代之吡唑基、可選地經取代之咪唑基、可選地經取代之吡啶基、或可選地經取代之吡𠯤基。在進一步實施例中，可選地經取代之雜芳基經下列中之一或多者取代：C 1-6烷基，諸如甲基、乙基、或異丙基；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；鹵基，諸如F；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；C 3-6環烷基，諸如環丙基或環丁基；或C 3-6環烷基磺醯基，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。在又其他實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在仍其他實施例中，R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 。在進一步實施例中，R 6係甲基、異丙基、三級丁基、CHF 2、C(CH 3) 2F、C(CH 3) 2OH、CH(CH 3)OH、C(O)N(CH 3) 2、NH(環丙基)、 、 、 、 、苯基、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在仍進一步實施例中，R 6係甲基、異丙基、三級丁基、CF 3、CHF 2、C(CH 3)F 2、C(CH 3) 2F、C(CH 3) 2OH、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
在仍進一步實施例中，R 2係 、 、或 ，其中R 6及R 7獨立地係H、鹵基、C 1-6烷基、或C 1-6鹵烷基；且R 8係H、C 1-6烷基、C 1-6鹵烷基、C 3-6環烷基、可選地經取代之芳基、或雜芳基。在又其他實施例中，R 6及R 7獨立地係H、鹵基、C 1-6烷基、C 1-6鹵烷基、或NR yR z，其中R y及R z獨立地係H或C 1-6烷基；R 8係H、C 1-6烷基、C 1-6烷基、C 3-6環烷基、或雜芳基。在其他實施例中，R 6及R 7中之一或兩者係H。在仍其他實施例中，R 6或R 7中之一者係鹵基。在進一步實施例中，R 6或R 7中之一者係Cl或Br。在仍進一步實施例中，R 6或R 7中之一者係Cl。在又其他實施例中，R 6或R 7中之一者係C 1-6烷基。在仍進一步實施例中，R 6或R 7中之一者係甲基。在其他實施例中，R 6或R 7中之一者係C 1-6鹵烷基。在進一步實施例中，R 6或R 7中之一者係CHF 2、CH 2CF 3、CF 2H、或CF 3。在其他實施例中，R 6或R 7中之一者係CHF 2。在進一步實施例中，R 6或R 7中之一者係NR yR z，其中R y及R z獨立地係H或C 1-6烷基，諸如NH 2。在又其他實施例中，R 6或R 7中之一者係Cl、Br、甲基、CHF 2、或CF 3。在進一步實施例中，R 6或R 7中之一者係Cl、甲基、CHF 2、或NH 2。在其他實施例中，R 6或R 7中之一者係甲基、Cl、CHF 2、或CF 3。在一些實施例中，R 8係H。在其他實施例中，R 8係C 1-6烷基。在進一步實施例中，R 8係甲基、乙基、異丙基、或三級丁基。在又其他實施例中，R 8係甲基或異丙基。在仍其他實施例中，R 8係C 1-6鹵烷基。在又進一步實施例中，R 8係CHF 2、CH 2CF 3、CF 2H、CH 2CHF 2、或CF 3。在又進一步實施例中，R 8係CHF 2、CH 2CF 3、或CF 3。在其他實施例中，R 8係C 3-6環烷基。在進一步實施例中，R 8係環丙基。在又其他實施例中，R 8係可選地經取代之芳基。在仍進一步實施例中，R 8係苯基或氟苯基。在其他實施例中，R 8係雜芳基。在進一步實施例中，R 8係吡啶基。在仍其他實施例中，R 8係H、甲基、異丙基、三級丁基、CHF 2、CH 2CF 3、CH 2CHF 2、CH 2C(=O)CH 3、CH 2C(CH 3) 2OH、(CH 2) 2N(CH 3) 2、環丙基、氟苯基、吡啶基、CH 2-環丙基、或CH 2-環丁基。在又其他實施例中，R 8係甲基、異丙基、CHF 2、CH 2CF 3、CF 3、環丙基、及吡啶基。
在進一步實施例中，R 2係 ，其中R 6係H、C 1-6烷基、鹵基、C 1-6鹵烷基、或C 3-6環烷基；且R 8係H、C 1-6烷基、或C 1-6鹵烷基。在仍進一步實施例中，R 6係H、C 1-6烷基、鹵基、C 1-6鹵烷基、或C 3-6環烷基；且R 8係H或C 1-6烷基。在其他實施例中，R 6係H。在仍其他實施例中，R 6係C 1-6烷基，諸如甲基。在又其他實施例中，R 6係鹵基，諸如Cl或Br。在進一步實施例中，R 6係Cl。在其他實施例中，R 6係C 1-6鹵烷基，諸如CHF 2或CF 3。在又其他實施例中，R 6係C 3-6環烷基，諸如環丙基。在仍進一步實施例中，R 6係H、甲基、Cl、CHF 2、CF 3、或環丙基。在一些實施例中，R 8係H。在其他實施例中，R 8係C 1-6烷基，諸如甲基、乙基、或異丙基。在又其他實施例中，R 8係C 1-6鹵烷基，諸如CF 3或CHF 2。在其他實施例中，R 8係甲基。
在又其他實施例中，R 2係 、 、 、 、 、或 。在此等結構中，W係S或NR 15；W 1係S、O、或NR 15；R 10、R 11、R 12、R 13、及R 14各自獨立地係H、C 1-6烷基、C 1-6鹵烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6羥基烷基、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 2-6烯基、CN、鹵基、(CR vR x) pNR yR z、C(O)NR y2R z2、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之雜環基(伸烷基)、可選地經取代之芳基、或可選地經取代之雜芳基；R v及R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6羥基烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、或C(O)OC 1-6烷基；R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基；p係0、1、2、或3；且R 15係H或C 1-6烷基。
在一些實施例中，W係S。在其他實施例中，W係NR 15。在一些實施例中，W 1係S。在其他實施例中，W 1係O。在進一步實施例中，W 1係NR 15。在一些實施例中，R 10、R 11、R 12、R 13、及R 14係H。在進一步實施例中，R 10、R 11、R 12、及R 13係H。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷基。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6鹵烷基。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷氧基。在仍其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷氧基(伸烷基)。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6羥基烷基。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6鹵烷氧基。在仍其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6鹵烷氧基(伸烷基)。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 2-6烯基。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係CN。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係鹵基。在仍進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係(CR) vR x) pNR yR z。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C(O)NR y2R z2。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之C 3-8環烷基。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜環基。在仍其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜環基(伸烷基)。在仍進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之芳基。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜芳基。在一些實施例中，R v及R x中之一或兩者係H。在其他實施例中，R v及R x中之一或兩者係C 1-6烷基。在一些實施例中，R y及R z中之一或兩者係H。在其他實施例中，R y及R z中之一或兩者係C 1-6烷基。在進一步實施例中，R y及R z中之一或兩者係C 3-6環烷基。在又其他實施例中，R y及R z中之一或兩者係C 1-6羥基烷基。在仍進一步實施例中，R y及R z中之一或兩者係C 1-6鹵烷基。在進一步實施例中，R y及R z中之一或兩者係C(O)OC 1- 6烷基。在一些實施例中，R y2及R z2中之一或兩者係H。在其他實施例中，R y2及R z2中之一或兩者係C 1-6烷基。在進一步實施例中，R y2及R z2中之一或兩者係C 3-6環烷基。在一些實施例中，p係0。在其他實施例中，p係1。在進一步實施例中，p係2。在又其他實施例中，p係3。在一些實施例中，R 15係H。在其他實施例中，R 15係C 1-6烷基。
在仍進一步實施例中，R 2係 ，其中R 10、R 11、R 12、R 13、及R 14各自獨立地係H、C 1-6烷基、C 1-6鹵烷基、C 3-6環烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、鹵基、可選地經取代之芳基、可選地經取代之雜環基、可選地經取代之雜環基(伸烷基)、可選地經取代之雜芳基、或(CR vR x) pNR yR z。在其他實施例中，R 10、R 11、R 12、R 13、及R 14各自獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、可選地經取代之雜環基、可選地經取代之雜環基(伸烷基)、可選地經取代之雜芳基、或(CR vR x) pNR yR z。在一些實施例中，R 10、R 11、R 12、R 13、及R 14係H。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷基，諸如甲基或乙基。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷基，諸如甲基。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6鹵烷基，諸如CF 3、或C(CH 3) 2F。在又進一步實施例中，R 10、R 11、R 12、R 13、及/或R 14中之至少一者係C 3-6環烷基，諸如環丙基。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷氧基，諸如甲氧基。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷氧基(伸烷基)，諸如CH 2OCH 3或(CH 2) 2OCH 3。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係鹵基，諸如F、Br、或Cl。在仍進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之芳基，諸如未經取代之苯基。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜環基，諸如 、 、 、 、 、 、 、或 。在仍其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜環基，諸如 、 、 、或 。在其他實施例中，可選地經取代之雜環基係 。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜環基(伸烷基)。在仍進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係 、 、或 。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係 、或 。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係可選地經取代之雜芳基，諸如可選地經取代之吡啶基、可選地經取代之吡𠯤基、可選地經取代之嘧啶基、或可選地經取代之吡唑基。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在仍進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係(CR vR x) pNR yR z，諸如NH 2、NH(CH 3)、N(CH 3) 2、CH 2N(CH 3) 2、或CH 2CH 2N(CH 3) 2。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係(CR vR x) pNR yR z，諸如N(CH 3) 2、CH 2N(CH 3) 2、或CH 2CH 2N(CH 3) 2。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14各自獨立地係H、甲基、C(CH 3) 2F、環丙基、甲氧基、CH 2OCH 3、(CH 2) 2OCH 3、Br、F、Cl、苯基、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、N(CH 3) 2、CH 2N(CH 3) 2、或CH 2CH 2N(CH 3) 2。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14各自獨立地係H、甲基、環丙基、甲氧基、CH 2OCH 3、(CH 2) 2OCH 3、 、 、 、 、N(CH 3) 2、CH 2N(CH 3) 2、或CH 2CH 2N(CH 3) 2。在其他實施例中，R 10、R 13、及R 14各自係氫。在進一步實施例中，R 10、R 13、及R 14各自係氫；且R 11係鹵基。
在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係經取代之雜環基或經取代之雜環基(伸烷基)，其經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；OH；C 1-6羥基烷基，諸如C(CH 3) 2OH；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；或C 3-6環烷基，諸如環丙基、環丁基、或環戊基。在其他實施例中，經取代之雜環基或經取代之雜環基(伸烷基)經甲基、OH、或F中之一或多者取代。
在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係經取代之雜芳基，其經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、丙基、或異丙基；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；C 1-6鹵烷氧基，諸如OCF 3；C 3-6環烷基，諸如環丙基、環丁基、或環戊基；或C 3-6環烷基磺醯基，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。在又其他實施例中，經取代之雜芳基經F、CF 3、CHF 2、或甲基中之一或多者取代。在進一步實施例中，可選地經取代之雜芳基係經一個甲基取代之吡唑基。
在其他實施例中，R 2係 ，其中R 10、R 11、R 12、及R 13各自獨立地係H、C 1-6烷基、或鹵基，且R 15係H或C 1-6烷基。在進一步實施例中，R 10、R 11、R 12、及R 13係H。在其他實施例中，R 10、R 11、R 12、及R 13中之至少一者係C 1-6烷基。在進一步實施例中，R 10、R 11、R 12、及R 13中之至少一者係鹵基。在又其他實施例中，R 10、R 11、R 12、及R 13中之至少一者係Br。在一些實施例中，R 15係H。在其他實施例中，R 15係C 1-6烷基。在進一步實施例中，R 15係甲基。在又其他實施例中，R 15係H或甲基。
在進一步實施例中，R 2係 或 ，其中R 10、R 11、R 12、R 13、及R 14各自獨立地係H、鹵基、或C 1-6烷基。在一些實施例中，R 2係 。在其他實施例中，R 2係 。在一些實施例中，R 10、R 11、R 12、R 13、及R 14係H。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係鹵基。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷基。
在又其他實施例中，R 2係 ，其中R 10、R 11、R 12、R 13、及R 14各自獨立地係H、鹵基、或C 1-6烷基。在一些實施例中，R 10、R 11、R 12、R 13、及R 14係H。在其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係鹵基。在進一步實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係Br。在又其他實施例中，R 10、R 11、R 12、R 13、及R 14中之至少一者係C 1-6烷基。
在仍進一步實施例中，R 2係 、 、或 ，其中R 10、R 11、R 12、及R 13各自獨立地係H、C 1-6烷基、或鹵基。在一些實施例中，R 2係 。在其他實施例中，R 2係 。在進一步實施例中，R 2係 。在一些實施例中，R 10、R 11、R 12、及R 13係H。在其他實施例中，R 10、R 11、R 12、及R 13中之至少一者係鹵基。在進一步實施例中，R 10、R 11、R 12、及R 13中至少一者係F。在又其他實施例中，R 10、R 11、R 12、及R 13中之至少一者係C 1-6烷基。在仍進一步實施例中，R 10、R 11、R 12、及R 13中至少一者係甲基。在又其他實施例中，R 10、R 11、R 12、及R 13各自獨立地係H、甲基、或F。
在其他實施例中，R 2係 ，其中R 6在本文中定義，且R 7係H。在又其他實施例中，R 2係 、 、 、 、 、 、 、 、或 。在仍其他實施例中，R 2係 、 、 、 、 、 、 、 、 、或 。
在進一步實施例中，R 2係 ，其中R 6在本文中定義，且R 7係CH 3。在其他實施例中，R 2係 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、或 。
在又其他實施例中，R 2係 ，其中R 6在本文中定義，且R 7係環丙基。在進一步實施例中，R 2係 、 、或 。在仍進一步實施例中，R 2係 、 、 、或 。
在仍進一步實施例中，R 2係 ，其中R 6在本文中定義，且R 7係CHF 2。在其他實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、 、 、 、 、 、 、或 。
在其他實施例中，R 2係 ，其中R 6在本文中定義，且R 7係CF 3。在仍其他實施例中，R 2係 、 、或 。在又其他實施例中，R 2係 或 。
在進一步實施例中，R 2係 ，其中R 6本文中定義，且R 7係CN。在仍進一步實施例中，R 2係 。
在又其他實施例中，R 2係 ，其中R 6在本文中定義，且R 7係Br或Cl。在進一步實施例中，R 2係 、 、 、或 。
在仍進一步實施例中，R 2係 ，其中R 6在本文中定義，且R 7係苯基或吡啶基。在其他實施例中，R 2係 或 。
在進一步實施例中，R 2係 ，其中R 6在本文中定義，且R 7係H。在又其他實施例中，R 2係 、 、 、 、 、 、 、 、 、 、或 。在仍其他實施例中，R 2係 或 。
在其他實施例中，R 2係 ，其中R 6至R 8係在本文中定義。在仍其他實施例中，R 2係 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、或 。
在進一步實施例中，R 2係 或 ，其中R 6至R 8係在本文中定義。在仍進一步實施例中，R 2係 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、 、 、 、 、 、或 。
在其他實施例中，R 2係 ，其中R 6係可選地經取代之雜環基。在又其他實施例中，R 2係 或 。在仍其他實施例中，R 2係 。
在進一步實施例中，R 2係 ，其中R 6係可選地經取代之雜芳基。在仍進一步實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
在其他實施例中，R 2係 ，其中R 6係可選地經取代之芳基。在仍其他實施例中，R 2係 、 、 、 、 、 、或 。
在進一步實施例中，R 2係 ，其中R 6係C 1-6烷基、C 1-6鹵烷基、或C 1-6羥基烷基。在仍進一步實施例中，R 2係 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、 、 、 、或 。
在其他實施例中，R 2係 ，其中R 6係可選地經取代之C 3-8環烷基。在又其他實施例中，R 2係 、 、 、或 。
在又其他實施例中，R 2係 ，其中R 6係C(O)NR y2R z2或(CR vR x) pNR yR z，且R y2、R z2、p、R v、R x、R y、及R z係在本文中定義。在其他實施例中，R 2係 或 。
在其他實施例中，R 2係 ，其中R 6係H、C 1-6烷基、或可選地經取代之芳基。在仍其他實施例中，R 2係 、 、或 。在又其他實施例中，R 2係 、 、 、 、或 。
在進一步實施例中，R 2係 或 ，其中R 6係C 1-6羥基烷基。在又進一步實施例中，R 2係 或 。
在其他實施例中，R 2係 ，其中R 8係C 1-6烷基，且R 6係在本文中定義。在仍其他實施例中，R 2係 、 、 、 、 、或 。
在進一步實施例中，R 2係 ，其中R 10至R 14係在本文中定義。在仍進一步實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。在又其他實施例中，R 2係 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
在其他實施例中，R 2係 ，其中R 13係H，且R 10、R 11、R 12、R 14、及R 15係在本文中定義。在又其他實施例中，R 2係 或 。
在一些實施例中，式 I之化合物係式 I-A或其醫藥上可接受之鹽： I-A，諸如 I-A-1或 I-A-2，其中R 1、R 2、R 5、L、及m係在本文中定義。在其他實施例中，化合物係 I-A-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-A-2或其醫藥上可接受之鹽。
在其他實施例中，式 I之化合物係式 I-B或其醫藥上可接受之鹽： I-B，諸如 I-B-1或 I-B-2，其中R 1、R 2、R 5、及m係在本文中定義。在進一步實施例中，化合物係 I-B-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-B-2或其醫藥上可接受之鹽。
在進一步實施例中，式 I之化合物係式 I-C或其醫藥上可接受之鹽： I-C，諸如 I-C-1或 I-C-2，其中R 1、R 2、R 5、及m係在本文中定義。在其他實施例中，化合物係 I-C-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-C-2或其醫藥上可接受之鹽。
在仍其他實施例中，式 I之化合物係式 I-D或其醫藥上可接受之鹽： I-D，諸如 I-D-1或 I-D-2，其中R 1、R 2、R 5、及m係在本文中定義。在一些實施例中，化合物係 I-D-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-D-2或其醫藥上可接受之鹽。
在仍進一步實施例中，式 I之化合物係式 I-E或其醫藥上可接受之鹽： I-E，諸如 I-E-1或 I-E-2，其中R 1、R 2、R 5、及m係在本文中定義。在其他實施例中，化合物係 I-E-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-E-2或其醫藥上可接受之鹽。
在其他實施例中，式 I之化合物係式 I-F或其醫藥上可接受之鹽： I-F，諸如 I-F-1或 I-F-2，其中R 1、R 2、R 5、及m係在本文中定義。在又其他實施例中，化合物係 I-F-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-F-2或其醫藥上可接受之鹽。
在進一步實施例中，式 I之化合物係式 I-G或其醫藥上可接受之鹽： I-G，諸如 I-G-1或 I-G-2，其中R 1、R 2、R 5、及m係在本文中定義。在仍進一步實施例中，化合物係 I-G-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-G-2或其醫藥上可接受之鹽。
在又其他實施例中，式 I之化合物係式 I-H或其醫藥上可接受之鹽： I-H，諸如 I-H-1或 I-H-2，其中R 1、R 2、R 5、及m係在本文中定義。在其他實施例中，化合物係 I-H-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-H-2或其醫藥上可接受之鹽。
在仍進一步實施例中，式 I之化合物係式 I-I或其醫藥上可接受之鹽： I-I，諸如 I-I-1或 I-I-2，其中R 1、R 2、R 5、及m係在本文中定義。在其他實施例中，化合物係 I-I-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-I-2或其醫藥上可接受之鹽。
在其他實施例中，式 I之化合物係式 I-J或其醫藥上可接受之鹽： I-J，諸如 I-J-1或 I-J-2，其中R 1、R 2、R 5、及m係在本文中定義。在又其他實施例中，化合物係 I-J-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-J-2或其醫藥上可接受之鹽。
在進一步實施例中，式 I之化合物係式 I-K或其醫藥上可接受之鹽： I-K，諸如 I-K-1或 I-K-2，其中R 1、R 2、R 5、及m係在本文中定義。在其他實施例中，化合物係 I-K-1或其醫藥上可接受之鹽。在其他實施例中，化合物係 I-K-2或其醫藥上可接受之鹽。
在仍其他實施例中，式 I之化合物係式 I-L或其醫藥上可接受之鹽： I-L，其中R 1、R 2、R 5、L、及m係在本文中定義。在進一步實施例中，化合物係 I-L-1或其醫藥上可接受之鹽。
在又進一步實施例中，式 I之化合物係式 I-M或其醫藥上可接受之鹽： I-M，其中R 1、R 2、R 5、L、及m係在本文中定義。在其他實施例中，化合物係 I-M-1或其醫藥上可接受之鹽。
在一些實施例中，本揭露之化合物係表1之化合物、及其醫藥上可接受之鹽及/或類同位素分子中之任一或多者。具有式 I之化合物進一步揭示於範例中且包括於本揭露中。包括其醫藥上可接受之鹽以及中性形式。
本揭露進一步提供本文所述之化合物中之任一者的R鏡像異構物、S鏡像異構物、或外消旋混合物。在一些實施例中，化合物係S鏡像異構物。在其他實施例中，化合物係R鏡像異構物。在進一步實施例中，化合物係外消旋的。
在另一實施例中，本揭露之化合物可經鏡像異構富集，例如，化合物之鏡像異構物過量或「ee」大於約5%，如藉由掌性HPLC所測量。在一些實施例中，ee大於約10%。在其他實施例中，ee大於約20%。在進一步實施例中，ee大於約30%。在又其他實施例中，ee大於約40%。在仍進一步實施例中，ee大於約50%。在其他實施例中，ee大於約60%。在進一步實施例中，ee大於約70%。在仍其他實施例中，ee大於約80%。在又進一步實施例中，ee大於約85%。在其他實施例中，ee大於約90%。在進一步實施例中，ee大於約91%。在又其他實施例中，ee大於約92%。在仍進一步實施例中，ee大於約93%。在其他實施例中，ee大於約94%。在進一步實施例中，ee大於約95%。在仍其他實施例中，ee大於約96%。在又進一步實施例中，ee大於約97%。在其他實施例中，ee大於約98%。在進一步實施例中，ee大於約99%。
本揭露涵蓋本揭露之化合物之製備及用途。本揭露之化合物之鹽可在化合物之最終單離及純化期間製備，或根據需要藉由使該化合物與酸或鹼反應而單獨製備。 治療方法
本揭露之化合物具有若干用途，如本文所述。在一些實施例中，本揭露之化合物可用於穩定突變PAH蛋白之方法中。此等方法包含使蛋白質與本文所述之一或多種化合物或其醫藥上可接受之鹽接觸。本揭露之化合物可為其疾病僅藉由飲食不能很好控制之患者提供更佳的Phe控制，並減輕患者苯酮尿症的嚴重程度。因此，相較於未投予本揭露之化合物之苯酮尿症患者，投予本揭露之化合物之患者將具有更佳的生活品質，例如更正常的生活方式及/或沒有或更少的飲食限制。在一些實施例中，投予本揭露之化合物之患者可經歷執行功能之增加、焦慮症狀減少、及/或注意力缺陷過動症症狀減輕。
如本文中所使用，用語「突變PAH基因(mutant PAH gene)」係指PAH之完整DNA序列，其在一或多個方面不同於在各種策劃資料庫中任一者中公佈之公認序列（「基礎基因(the basis gene)」）。作為一個實例，GenBank登錄號NG_008690.2所描述之序列描述了基礎基因。
如本文中所使用之用語「突變PAH蛋白(mutant PAH protein)」係指含有相對於由參考編碼之胺基酸序列，在胺基酸序列中含有至少一個突變的PAH蛋白。參考人類PAH蛋白係由Genbank登錄號NP_000268描述，且含有452個胺基酸。可使用本領域中已知之方法來識別PAH蛋白突變。在一些實施例中，突變PAH蛋白含有至少一個R408W、R261Q、R243Q、Y414C、L48S、A403V、I65T、R241C、L348V、R408Q、或V388M突變。在其他實施例中，突變PAH蛋白含有至少一個R408W、Y414C、I65T、F39L、R408Q、L348V、R261Q、A300S、或L48S突變。在仍其他實施例中，突變PAH蛋白含有至少一個R408W、R243Q、R408Q、V388M、或L348V突變。在又其他實施例中，突變PAH蛋白含有至少一個R408W突變。在進一步實施例中，突變PAH蛋白含有至少兩個R408W突變。在進一步實施例中，突變PAH蛋白含有至少一個R261Q突變。在又其他實施例中，突變PAH蛋白含有至少一個R243Q突變。在又其他實施例中，突變PAH蛋白含有至少一個Y414C突變。在仍進一步實施例中，突變PAH蛋白含有至少一個L48S突變。在其他實施例中，突變PAH蛋白含有至少一個A403V突變。在進一步實施例中，突變PAH蛋白含有至少一個I65T突變。在又進一步實施例中，突變PAH蛋白含有至少一個R241C突變。在又其他實施例中，突變PAH蛋白含有至少一個L348V突變。在進一步實施例中，突變PAH蛋白含有至少一個R408Q突變。在其他實施例中，突變PAH蛋白含有至少一個V388M突變。在其他實施例中，突變PAH蛋白含有至少一個F39L突變。在仍進一步實施例中，突變PAH蛋白含有至少一個A300S突變。在又進一步實施例中，突變PAH蛋白含有至少一個L48S突變。
在其他實施例中，本揭露提供用於相較於野生型PAH穩定突變苯丙胺酸羥化酶(PAH)蛋白之活性的方法。此類方法包括使苯丙胺酸羥化酶與本文所述之一或多種化合物或其醫藥上可接受之鹽接觸。如本文所使用之用語「穩定(stabilizing)」係指調節PAH酶之活性或數量，使其催化苯丙胺酸之芳族側鏈之羥基化的速率，相較於基線PAH催化速率，更類似於具有野生型PAH，亦即沒有突變PAH基因突變之對照群體之PAH催化速率。在一些態樣中，用語「穩定」係指調節對象之PAH的活性，使其催化苯丙胺酸之芳族側鏈之羥基化的通量更類似於沒有突變PAH基因突變之對照對象群體之PAH催化通量。在一些實施例中，PAH之「穩定」活性包括相較於基線增加酶PAH之水平。藉由增加穩定的活性PAH蛋白之積累，相較於投予本揭露之化合物或包含本揭露之化合物之醫藥組成物前對象之飲食Phe的基線水平，對象之毒性Phe水平可降低。
在一些實施例中，本揭露提供用於將罹患苯酮尿症之對象之血液苯丙胺酸濃度降低至小於或等於約600 µM之濃度的方法。在其他實施例中，血液Phe濃度被降低至小於或等於約360 µM之濃度。在其他實施例中，本揭露提供用於相較於未經治療之基線降低血液Phe濃度之方法。在一些實施例中，相較於未經治療之基線，對象之血液Phe濃度降低一定百分比，包括但不限於至少約10%、至少約20%、至少約30%、至少約40%、至少約50%、至少約60%、至少約70%、至少約80%、或至少約90%。在其他實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約10%。在進一步實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約20%。在又其他實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約30%。在仍進一步實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約40%。在其他實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約50%。在進一步實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約60%。在又其他實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約70%。在仍進一步實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約80%。在其他實施例中，相較於未經治療之基線，對象之血液Phe濃度降低至少約90%。對象之Phe濃度可藉由血液測試來判定，且用於測量此類水平之方法係所屬技術領域中已知的。在一些實施例中，使用本揭露之化合物達成之Phe濃度降低係結合對象主動地管理其飲食Phe攝入而獲得。在其他實施例中，Phe濃度降低係結合對象維持Phe限制性飲食而獲得。
在一些實施例中，用本揭露之化合物或包含本揭露之化合物之醫藥組成物來治療對象。化合物在對象中係以足以穩定PAH蛋白、或足以降低對象之血液苯丙胺酸濃度、或其組合之量投予。
在進一步實施例中，對象係人類患者，諸如需要治療之超過18歲之人類成人。在又進一步實施例中，人類患者係小於18歲之人類兒童。在仍進一步實施例中，人類患者係12歲至18歲之間的人類兒童。在又其他實施例中，人類患者係小於12歲之人類兒童。在實施例中之任一者中，對象患有苯酮尿症(PKU)，可選地經典PKU或重度PKU。在一些實施例中，在投予本揭露之化合物或包含本揭露之化合物之醫藥組成物前，對象具有大於約600 µM之血液Phe濃度。在其他實施例中，對象之血液Phe濃度在投予前大於約700 µM。在進一步實施例中，對象之血液Phe濃度在投予前大於約800 µM。在仍進一步實施例中，對象之血液Phe濃度在投予前大於約900 µM。在又其他實施例中，對象之血液Phe濃度在投予前大於約1000 µM。在進一步實施例中，對象之血液Phe濃度在投予前大於約1100 µM。在其他實施例中，對象之血液Phe濃度在投予前大於約1200 µM。
除了本揭露之化合物外，本發明方法亦涵蓋向對象投予額外治療劑。在一些實施例中，額外治療劑係選自已知可用於穩定突變PAH蛋白及/或降低血液Phe濃度之藥物。額外治療劑不同於本揭露之化合物。在一些實施例中，額外治療劑係沙丙蝶呤(sapropterin)或墨蝶呤(sepiapterin)。在其他實施例中，額外治療劑係營養補充劑。可使用之營養補充劑包括含有胺基酸及其他營養物之營養補充劑。在進一步實施例中，營養補充劑含有大量中性胺基酸，諸如白胺酸、酪胺酸、色胺酸、甲硫胺酸、組胺酸、異白胺酸、纈胺酸、蘇胺酸。在其他實施例中，營養補充劑含有酪胺酸。在進一步實施例中，營養補充劑含有酪蛋白醣肽，亦即天然不含其純形式Phe之牛奶肽。在其他實施例中，額外治療劑係酶受質或酶輔助因子。在又其他實施例中，酶受質或輔助因子係四氫生物喋呤。在其他實施例中，額外治療劑係生物素類似物。在進一步實施例中，額外治療劑係生物治療劑、合成生物劑、微生物群或益生菌。在又其他實施例中，生物治療劑、合成生物劑、微生物群或益生菌含有基因修飾之苯丙胺酸解氨酶(phenylalanine ammonia lyase, PAL)基因，諸如，例如大腸桿菌Nissle PAL。基因修飾之大腸桿菌Nissle PAL生物療法之實例包括SYNB1934及SYNB1618、及類似者。在仍進一步實施例中，額外治療劑係胺基酸轉運蛋白之抑制劑。在一些實施例中，胺基酸轉運蛋白係B 0AT1（亦稱為SLC6A19），且額外治療劑係SLC6A19抑制劑。SLC6A19抑制劑之實例包括尼美舒利、苯托品、NSC63912、NSC22789、桂溴胺、CB3、E62、JNT-517、及類似者。
本揭露之化合物及額外治療劑可同時或依序投予以達到所欲效應。另外，本揭露之化合物及額外治療劑可在單個組成物或兩個獨立組成物中投予。
額外治療劑係以提供其所欲治療效應之量投予。各額外治療劑之有效劑量範圍在所屬技術領域中已知，且額外治療劑在此類確定的範圍內向有需要之個體投予。
本揭露之化合物及額外治療劑可作為單一單位劑量一起投予或以多個單位劑量分開投予，其中本揭露之化合物在額外治療劑之前投予，反之亦然。可投予一或多個劑量的本揭露之化合物及/或一或多個劑量的額外治療劑。
本揭露之化合物亦可利用非藥理學技術依序或同時投予。在一些實施例中，患者使用非藥理學技術以維持較低Phe水平。在其他實施例中，非藥理學技術係投予低Phe之飲食。所屬技術領域中具有通常知識者將能夠判定哪種飲食以維持適當的Phe水平。在一些實施例中，苯胺飲食含有約200至約500 mg/天（10歲或更小之患者）的Phe或少於約600 mg/天（超過10歲之患者）。在其他實施例中，飲食可包括限制或消除Phe高之一或多種食物，諸如大豆、蛋白、蝦、雞胸肉、螺旋藻、西洋菜、魚、堅果、螯蝦、龍蝦、鮪魚、火雞、豆科植物、及低脂茅屋起司。
劑量之實例係在每天每kg對象體重約0.001 mg至約100 mg化合物之範圍內，其呈單一或分開的劑量單位（例如BID、TID、QID）。對於70-kg人類，合適劑量量係約0.05至約7 g/天。
在一些實施例中，本文所述之一或多種化合物之治療有效量係有效穩定本文所述之突變PAH蛋白的量。在其他實施例中，本文所述之一或多種化合物之治療有效量係有效降低血液苯丙胺酸濃度的量。
除非另有說明，本文所述化合物之量係以游離鹼為基礎給出的。亦即，該等量指示投予之化合物的量，不包括例如溶劑或相對離子（例如在醫藥上可接受之鹽中）。 醫藥組成物
本揭露亦提供包含本揭露之化合物及醫藥上可接受之載劑或賦形劑之醫藥組成物。
本揭露之方法可藉由投予純化合物或醫藥組成物形式之本揭露之化合物來達成。本揭露之醫藥組成物或純化合物之投予可以在主治醫師判定之任何時間段進行。通常，醫藥組成物不含有在投予時會造成不良反應之毒性、致癌或誘變化合物。
醫藥組成物包括其中本揭露之化合物係以有效量投予以達成其預期目的之醫藥組成物。確切配方、投予途徑、及劑量由個別醫師來判定。
本揭露之化合物可藉由任何合適途徑投予，例如，藉由口服、口腔、吸入、舌下、直腸、陰道、腦池內或藉由腰椎穿刺鞘內、經尿道、經鼻、經皮(percutaneous)（亦即經皮(transdermal)）或胃腸外（包括靜脈內、肌內、皮下、冠狀動脈內、皮膚內、乳房內、腹膜內、關節內、鞘內、球後、肺內注射、及/或特定部位處之外科植入）來投予。腸胃外投予可使用針頭及注射器或使用高壓技術來達成。
上文所提及之額外治療活性劑如所屬技術領域中所描述來製備及投予，其中之一或多種可與本揭露之化合物組合使用。
本揭露之化合物可以與根據預期投予途徑及標準醫藥實務選擇之醫藥載劑混合投予。根據本揭露使用之醫藥組成物以習知方式，使用一或多種生理學上可接受之載劑配製，該等載劑包含促進本揭露之化合物處理之賦形劑及/或助劑。
本揭露之化合物或醫藥組成物之投予可藉由使得化合物遞送至作用位點之任何方法來實現。此等方法包括口服途徑、十二指腸內途徑、腸胃外注射（包括靜脈內、動脈內、皮下、肌內、血管內、腹膜內或輸注）、局部（例如經皮施用）、直腸投予、經由導管或支架局部遞送或藉由吸入。化合物亦可脂肪內或鞘內投予。
所投予之化合物之量將取決於被治療的對象、病症或病況之嚴重程度、投予速率、化合物的處置、及處方醫生的判斷。所欲劑量可以單次劑量投予，或以適當的間隔以多次劑量投予，例如以每天一、二、三、四次、或更多個子劑量投予。在一些實施例中，本文所揭示之化合物在廣泛劑量範圍內有效。例如，在成年人類的治療中，每天含有約0.01 mg至2000 mg本文揭示之化合物的劑型係可以使用之劑型之實例。確切的劑量將取決於投予途徑、化合物的投予形式、待治療的對象、待治療對象的體重、以及主治醫師之偏好及經驗。在一些情況下，低於上述範圍下限的劑量水平可係足夠的，而在其他情況下，可以使用更大的劑量而不會引起任何有害的副作用，例如，藉由將此種大劑量分成若干小劑量在全天投予。
在一些實施例中，本揭露之化合物係以單次劑量投予。
通常，此等投予將藉由固體口服劑型，諸如錠劑或膠囊來進行。然而，可根據需要使用其他途徑。亦可使用單次劑量的化合物治療急性病況。
在一些實施例中，本揭露之化合物可以多次劑量投予。給藥可係每天約一次、兩次、三次、四次、五次、六次、或多於六次。在另一實施例中，將本文所述之化合物及另一治療劑每天一起投予約一次至每天一起投予約6次。根據需要，本文所揭示之化合物之投予可繼續。在一些實施例中，在持續的基礎上長期投予化合物，例如用於治療慢性效應。
本揭露之化合物之有效量可藉由具有類似效用之治療劑之任何接受之投予方式以單次或多次劑量投予，包括直腸、口腔、鼻內、及經皮途徑，藉由動脈內注射、靜脈內、腹膜內、腸胃外、肌內、皮下、口服、局部、或作為吸入劑投予。
醫藥組成物可係例如適於口服投予之錠劑、膠囊、丸劑、粉劑、緩釋配方、溶液、懸浮液形式，適於腸胃外注射之無菌溶液、懸浮液或乳劑形式，適於局部投予之軟膏或乳膏形式，或適於直腸投予之栓劑形式。醫藥組成物可呈適用於精確劑量之單次投予的單位劑型。醫藥組成物將包括一或多種習知醫藥載劑或賦形劑及本文所揭示之化合物作為活性成分。另外，其可包括其他藥劑或醫藥劑、載劑、佐劑等。
例示性腸胃外投予形式包括本揭露之化合物在無菌水溶液、例如水性丙二醇或右旋糖溶液中之溶液或懸浮液。若為所欲，此類劑型可經適當地緩衝。 用於口服投予之醫藥組成物
在一些實施例中，本揭露提供一種醫藥組成物，其用於口服投予含有本揭露之化合物及適用於口服投予之醫藥賦形劑。
在一些實施例中，本揭露提供一種用於口服投予之固體醫藥組成物，其含有：(i)有效量的本揭露之化合物；可選地(ii)有效量的第二治療劑；及(iii)適於口服投予之醫藥賦形劑。在一些實施例中，該組成物進一步含有：(iv)有效量的第三治療劑。
在一些實施例中，醫藥組成物可係適合口服攝取之醫藥組成物。含有適於口服投予之本揭露之化合物的醫藥組成物可以離散的劑型存在，諸如膠囊、扁囊劑或錠劑，或液體或氣霧噴霧劑，每種劑型含有預定量的活性成分，如粉末或顆粒、溶液或在水性或非水液體中之懸浮液、水包油乳液、或油包水液體乳液。此類劑型可藉由藥學方法中之任一者製備，但所有方法包括使本揭露之化合物與載劑結合之步驟，該載劑構成一或多種必要成分。通常而言，藉由將本揭露之化合物與液體載劑或細分的固體載劑或兩者均勻且緊密地混合，然後若需要，則將產品成型為所欲外觀，來製備組成物。例如，錠劑可藉由壓制或模製、可選地與一或多種輔助成分一起製備。壓制錠劑可以藉由在合適的機器中壓制自由流動形式諸如粉末或顆粒的活性成分，可選地與賦形劑混合來製備，該賦形劑係諸如但不限於黏合劑、潤滑劑、惰性稀釋劑、及/或界面活性劑或分散劑。模製錠劑可藉由在適合的機器中模製以惰性液體稀釋劑濕潤之粉末狀化合物之混合物來製成。
本揭露進一步涵蓋包含活性成分之無水醫藥組成物及劑型，因為水可促進一些化合物之降解。例如，在醫藥技術領域中可添加水（例如5%）作為模擬長期儲存之手段，以便判定諸如保存期限或配方隨時間之穩定性等特徵。含有本揭露之化合物之無水醫藥組成物及劑型可使用無水或低含水量之成分及低水分或低濕度條件來製備。若預期在製造、封裝、及/或儲存期間與水分及/或濕氣大量接觸，則包含含有乳糖之本揭露之化合物之醫藥組成物及劑型可以製成無水的。可以製備及儲存無水醫藥組成物以維持其無水性質。因此，可以使用已知的防止暴露於水的材料包裝無水組成物，使得其等可以包括在合適的處方集套組中。合適包裝之實例包括但不限於氣密密封箔、塑膠或類似者、單位劑量容器、泡罩包裝、及條形包裝。
本揭露之化合物可根據習知醫藥調製(compounding)技術與醫藥載劑密切混合而組合。取決於投予所欲之製劑形式，載劑可採用各種形式。在製備用於口服劑型之組成物時，在口服液體製劑（諸如懸浮液、溶液及酏劑）或氣霧劑的情況下，任何常用的醫藥介質皆可以用作載劑，諸如例如水、二醇、油、醇、調味劑、防腐劑、著色劑、及類似者；或在口服固體製劑的情況下，可使用載劑，諸如澱粉、糖、微晶纖維素、稀釋劑、顆粒劑、潤滑劑、黏合劑、及崩解劑，在一些實施例中，不使用乳糖。例如，合適的載劑包括粉末、膠囊、及錠劑，以及固體口服製劑。若為所欲，錠劑可藉由標準水性或非水性技術塗佈。
適用於醫藥組成物及劑型之黏合劑包括但不限於玉米澱粉、馬鈴薯澱粉、或其他澱粉、明膠、天然及合成樹膠諸如阿拉伯膠、藻酸鈉、藻酸、其他藻酸鹽、粉末狀黃蓍膠、瓜爾膠、纖維素及其衍生物（例如乙基纖維素、乙酸纖維素、羧甲基纖維素鈣、羧甲基纖維素鈉）、聚乙烯吡咯啶酮、甲基纖維素、預糊化澱粉、羥基丙基甲基纖維素、膠態二氧化矽、微晶纖維素及其混合物。
用於本文揭示之醫藥組成物及劑型之合適填充劑之實例包括但不限於滑石、碳酸鈣（例如顆粒或粉末）、微晶纖維素、粉末狀纖維素、葡萄糖結合劑、高嶺土、甘露醇、矽酸、山梨醇、澱粉、預糊化澱粉、及其混合物。
崩解劑可用於本揭露之組成物中，以提供當暴露於水性環境時崩解之錠劑。過多崩解劑可產生在瓶中可能崩解之錠劑。過少可能不足以發生崩解，且因此可能改變活性成分自劑型中釋放之速率及程度。因此，可以使用既不過少亦不過多而不利地改變活性成分釋放之足夠量的崩解劑來形成本文揭示之化合物的劑型。所使用之崩解劑之量可基於配方之類型及投予模式而變化，且可輕易地為所屬技術領域中具有通常知識者辨別。在醫藥組成物中，可使用約0.5重量%至約15重量%之崩解劑或約1重量%至約5重量%之崩解劑。可用於形成本揭露之醫藥組成物及劑型之崩解劑包括但不限於瓊脂、藻酸、碳酸鈣、微晶纖維素、交聯羧甲基纖維素鈉、交聯聚維酮、波拉克林鉀、澱粉羥乙酸鈉、馬鈴薯或木薯澱粉、其他澱粉、預糊化澱粉、其他澱粉、黏土、其他藻酸、其他纖維素、樹膠、或其混合物。
可用於形成本揭露之醫藥組成物及劑型之潤滑劑包括但不限於硬脂酸鈣、硬脂酸鎂、硬脂醯基反丁烯二酸鈉、礦物油、輕質礦物油、甘油、山梨醇、甘露醇、聚乙二醇、其他二醇、硬脂酸、月桂基硫酸鈉、滑石、氫化植物油（例如花生油、棉籽油、葵花油、芝麻油、橄欖油、玉米油、及大豆油）、硬脂酸鋅、油酸乙酯、月桂酸乙酯、瓊脂、或其混合物。額外的潤滑劑包括例如syloid矽膠、合成二氧化矽之凝結氣霧劑、或其混合物。可以可選地以小於醫藥組成物之約2重量%之量添加潤滑劑。
當口服投予需要水性懸浮液及/或酏劑時，其中之活性成分可以與各種甜味劑或調味劑、著色劑或染料及（若為所欲）乳化劑及/或懸浮劑，以及此類稀釋劑諸如水、乙醇、丙二醇、甘油及其各種組合進行組合。
錠劑可以不塗佈或藉由已知技術塗佈，以延遲在胃腸道中之崩解基吸收，且從而提供在更長時間之持續作用。例如，可以採用延時材料，諸如單硬脂酸甘油酯或二硬脂酸甘油酯。用於口服用途之配方亦可呈現為硬明膠膠囊，其中活性成分係與惰性固體稀釋劑例如碳酸鈣、磷酸鈣或高嶺土混合，或者為軟明膠膠囊，其中活性成分係與水或油介質例如花生油、液體石蠟或橄欖油混合。
可用於形成本揭露之醫藥組成物及劑型之界面活性劑包括但不限於親水性界面活性劑、親脂性界面活性劑、及其混合物。亦即，可以採用親水性界面活性劑之混合物，可以採用親脂性界面活性劑之混合物，或者可以採用至少一種親水性界面活性劑與至少一種親脂性界面活性劑之混合物。
合適的親水性界面活性劑通常可具有至少10的HLB值，而合適的親脂性界面活性劑通常可具有等於或小於約10的HLB值。用於表徵非離子兩親性化合物之相對親水性及疏水性之經驗參數係親水-親油平衡（「HLB」值）。具有較低HLB值之界面活性劑的親脂性或疏水性更強，且在油中的溶解度更大，而具有較高HLB值之界面活性劑之親水性更強，且在水溶液中的溶解度更大。
親水性界面活性劑通常被視為HLB值大於約10之化合物、以及HLB標度通常不適用的陰離子、陽離子、或兩性離子化合物。類似地，親脂性（亦即疏水性）界面活性劑係HLB值等於或小於約10之化合物。然而，界面活性劑之HLB值僅係通常用於配製工業、醫藥及化妝品乳液之粗略指南。
親水性界面活性劑可係離子或非離子界面活性劑。合適的離子界面活性劑包括但不限於烷基銨鹽；梭鏈孢酸鹽；胺基酸、寡肽、及多肽之脂肪酸衍生物；胺基酸、寡肽、及多肽之甘油酯衍生物；卵磷脂及氫化卵磷脂；溶血卵磷脂及氫化溶血卵磷脂；磷脂質及其衍生物；溶血磷脂質及其衍生物；肉鹼脂肪酸酯鹽；烷基硫酸酯之鹽；脂肪酸鹽；多庫酯鈉；醯基乳酸鹽；單甘油酯及二甘油酯之單乙醯化酒石酸酯及二乙醯化酒石酸酯；琥珀醯化之單甘油酯及二甘油酯；單甘油酯及二甘油酯之檸檬酸酯；及其混合物。
在前述組中，離子界面活性劑包括例如：卵磷脂、溶血卵磷脂、磷脂質、溶血磷脂質及其衍生物；肉鹼脂肪酸酯鹽；烷基硫酸酯之鹽；脂肪酸鹽；多庫酯鈉；丙烯酸酯；單甘油酯及二甘油酯之單乙醯化酒石酸酯及二乙醯化酒石酸酯；琥珀醯化之單甘油酯及二甘油酯；單甘油酯及二甘油酯之檸檬酸酯；及其混合物。
離子界面活性劑可係以下之離子化形式：卵磷脂、溶血卵磷脂、磷脂醯膽鹼、磷脂醯乙醇胺、磷脂醯甘油、磷脂酸、磷脂醯絲胺酸、溶血磷脂醯膽鹼、溶血磷脂醯乙醇胺、溶血磷脂醯甘油、溶血磷脂酸、溶血磷脂醯絲胺酸、PEG-磷脂醯乙醇胺、PVP-磷脂醯乙醇胺、脂肪酸之乳酸酯、硬脂醯基-2-乳酸酯、硬脂醯基乳酸酯、琥珀醯化單酸甘油酯、單/二酸甘油酯之單/二乙醯化酒石酸酯、單/二酸甘油酯之檸檬酸酯、膽醯肌胺酸(cholylsarcosine)、己酸酯、辛酸酯、癸酸酯、月桂酸酯、肉豆蔻酸酯、棕櫚酸酯、油酸酯、蓖麻油酸酯、亞油酸酯、亞麻酸酯、硬脂酸酯、月桂基硫酸酯、十四烷基硫酸酯、多庫酯、月桂醯肉鹼、棕櫚醯肉鹼、肉豆蔻醯肉鹼、以及其鹽及混合物。
親水性非離子界面活性劑可包括但不限於烷基葡萄糖苷；烷基麥芽糖苷；烷基硫代葡萄糖苷；月桂基聚乙二醇甘油酯；聚氧化烯烷基醚，諸如聚乙二醇烷基醚；聚氧化烯烷基酚，諸如聚乙二醇烷基酚；聚氧化烯烷基酚脂肪酸酯，諸如聚乙二醇脂肪酸單酯及聚乙二醇脂肪酸二酯；聚乙二醇甘油脂肪酸酯；聚甘油脂肪酸酯；聚氧化烯山梨糖醇脂肪酸酯，諸如聚乙二醇山梨糖醇脂肪酸酯；多元醇與由甘油酯、植物油、氫化植物油、脂肪酸、及甾醇組成之群組之至少一個成員的親水性轉酯化產物；聚氧乙烯甾醇、衍生物、及其類似物；聚氧乙基化維生素及其衍生物；聚氧乙烯-聚氧丙烯嵌段共聚物；及其混合物；聚乙二醇山梨糖醇脂肪酸酯以及多元醇與由三酸甘油酯、植物油、及氫化植物油組成之群組之至少一個成員之親水性轉酯化產物。多元醇可係甘油、乙二醇、聚乙二醇、山梨糖醇、丙二醇、戊二醇、或醣。
其他親水性非離子界面活性劑包括但不限於PEG-10月桂酸酯、PEG-12月桂酸酯、PEG-20月桂酸酯、PEG-32月桂酸酯、PEG-32二月桂酸酯、PEG-12油酸酯、PEG-15油酸酯、PEG-20油酸酯、PEG-20二油酸酯、PEG-32油酸酯、PEG-200油酸酯、PEG-400油酸酯、PEG-15硬脂酸酯、PEG-32二硬脂酸酯、PEG-40硬脂酸酯、PEG-100硬脂酸酯、PEG-20二月桂酸酯、PEG-25甘油三油酸酯、PEG-32二油酸酯、PEG-20甘油月桂酸酯、PEG-30甘油月桂酸酯、PEG-20甘油硬脂酸酯、PEG-20甘油油酸酯、PEG-30甘油油酸酯、PEG-30甘油月桂酸酯、PEG-40甘油月桂酸酯、PEG-40棕櫚仁油、PEG-50氫化蓖麻油、PEG-40蓖麻油、PEG-35蓖麻油、PEG-60蓖麻油、PEG-40氫化蓖麻油、PEG-60氫化蓖麻油、PEG-60玉米油、PEG-6癸酸/辛酸甘油酯、PEG-8癸酸/辛酸甘油酯、聚甘油基-10月桂酸酯、PEG-30膽固醇、PEG-25植物甾醇、PEG-30大豆甾醇、PEG-20三油酸酯、PEG-40山梨糖醇油酸酯、PEG-80山梨糖醇月桂酸酯、聚山梨醇酯20、聚山梨醇酯80、POE-9月桂基醚、POE-23月桂基醚、POE-10油基醚、POE-20油基醚、POE-20硬脂基醚、生育酚PEG-1000琥珀酸酯、PEG-24膽固醇、聚甘油基-10-油酸酯、吐溫40、吐溫60、蔗糖單硬脂酸酯、蔗糖單月桂酸酯、蔗糖單棕櫚酸酯、PEG 10-100壬基酚系列、PEG 15-100辛基酚系列、及泊洛沙姆。
合適的親脂性界面活性劑例如包括：脂肪醇；甘油脂肪酸酯；乙醯化甘油脂肪酸酯；低級醇脂肪酸酯；丙二醇脂肪酸酯；山梨糖醇脂肪酸酯；聚乙二醇山梨糖醇脂肪酸酯；甾醇及甾醇衍生物；聚氧乙基化甾醇及甾醇衍生物；聚乙二醇烷基醚；糖酯；糖醚；單甘油酯及二甘油酯之乳酸衍生物；多元醇與由甘油酯、植物油、氫化植物油、脂肪酸、及甾醇組成之群組之至少一個成員的疏水性轉酯化產物；油溶性維生素/維生素衍生物；及其混合物。在此組中，較佳的親脂性界面活性劑包括甘油脂肪酸酯、丙二醇脂肪酸酯、及其混合物，或者係多元醇與由植物油、氫化植物油、及甘油三酯組成之群組中之至少一個成員之疏水性轉酯化產物。
在一個實施例中，組成物可包括增溶劑，以確保本揭露之化合物之良好增溶基/或溶解，並使本揭露之化合物的沉澱最小化。此對於非口服用途之組成物可係重要的，例如用於注射之組成物。亦可以添加增溶劑以增加親水性藥物及/或其他組分諸如界面活性劑之溶解度，或者將組成物維持為穩定或均質的溶液或分散液。
合適的增溶劑的實例包括但不限於下列：醇及多元醇，諸如乙醇、異丙醇、丁醇、苄醇、乙二醇、丙二醇、丁二醇及其異構物、甘油、新戊四醇、山梨醇、甘露醇、還氧二元醇(transcutol)、二甲基異山梨醇、聚乙二醇(polyethylene glycol, PEG)、聚丙二醇、聚乙烯醇、羥基丙基甲基纖維素及其他纖維素衍生物、環糊精及環糊精衍生物；平均分子量為約200至約6000之聚乙二醇醚，諸如四氫糠醇PEG醚（四甘醇）或甲氧基PEG；聚乙二醇660 12-羥基硬脂酸酯；醯胺及其他含氮化合物，諸如2-吡咯啶酮、2-哌啶酮、ε-己內醯胺、N-烷基吡咯啶酮、N-羥基烷基吡咯啶酮、N-烷基哌啶酮、N-烷基己內醯胺、二甲基乙醯胺、及聚乙烯吡咯啶酮；酯，諸如丙酸乙酯、檸檬酸三丁酯、乙醯基三乙基檸檬酸酯、乙醯基三丁基檸檬酸酯、檸檬酸三乙酯、油酸乙酯、辛酸乙酯、丁酸乙酯、三醋精、丙二醇單乙酸酯、丙二醇二乙酸酯、ε-己內酯及其異構物、δ-戊內酯及其異構物、β-丁內酯及其異構物；以及所屬技術領域中已知的其他增溶劑，諸如二甲基乙醯胺、二甲基異山梨醇、N-甲基吡咯啶酮、單辛精、二乙二醇單乙醚、及水。
亦可使用增溶劑之混合物。實例包括但不限於三醋精、檸檬酸三乙酯、油酸乙酯、辛酸乙酯、二甲基乙醯胺、N-甲基吡咯啶酮、N-羥基乙基吡咯啶酮、聚乙烯吡咯啶酮、羥基丙基甲基纖維素、羥基丙基環糊精、乙醇、四甘醇、還氧二元醇、丙二醇、及二甲基異山梨醇。特別較佳的增溶劑包括山梨醇、甘油、三醋精、乙醇、平均分子量為約100 g/莫耳至約8000 g/莫耳之PEG、四甘醇、及丙二醇。
可包括之增溶劑的量不受特別限制。給定增溶劑之量可限於生物可接受之量，此可由所屬技術領域中具有通常知識者容易地判定。在一些情況下，包括遠超過生物可接受量的增溶劑可能係有利的，例如以使藥物濃度最大化，在將組成物提供至對象之前，使用習知技術諸如蒸餾或蒸發除去過量的增溶劑。因此，若存在增溶劑，則基於藥物及其他賦形劑之組合重量，增溶劑之重量比可以小於約10%、小於約25%、小於約50%、約100%、或至多小於約200%。若為所欲，亦可使用非常少量的增溶劑，諸如少於約5%、少於約2%、少於約1%、或甚至更少。通常，增溶劑可以小於約1%至約100%、更一般為小於約5重量%至約25重量%之量存在。
該組成物可進一步包括一或多種醫藥上可接受之添加劑及賦形劑。此類添加劑及賦形劑包括但不限於防黏劑、消泡劑、緩衝劑、聚合物、抗氧化劑、防腐劑、螯合劑、黏度調節劑、張力調節劑、食用香料、著色劑、增味劑、遮光劑、懸浮劑、黏合劑、填充劑、塑化劑、潤滑劑、及其混合物。 用於注射之醫藥組成物
在一些實施例中，本揭露提供一種用於注射之醫藥組成物，其含有本文所述之化合物及適用於注射之醫藥賦形劑。組成物中之藥劑之組分及量如本文所述。
本揭露之組成物可併入用於藉由注射投予之形式包括水性或油懸浮液或乳液。此類組成物可包含芝麻油、玉米油、棉籽油、花生油、含有甘露糖醇或右旋糖之酏劑、無菌水、及類似的醫藥媒劑。
鹽水中之水溶液亦習知用於注射。亦可使用乙醇、甘油、丙二醇、液體聚乙二醇、及類似者（及其合適混合物）、環糊精衍生物、及植物油。適當的流動性可例如藉由使用塗層（諸如卵磷脂）維持，以在分散液的情況下維持所需粒徑，及藉由使用界面活性劑維持。各種抗細菌及抗真菌劑，例如對羥基苯甲酸酯、氯丁醇、酚、山梨酸、硫柳汞、及類似者，可以引起防止微生物的作用。
無菌可注射溶液藉由將所需量的本揭露之化合物併入根據需要具有以上列舉之各種其他成分的適當溶劑中，接著過濾滅菌來製備。通常，藉由將各種滅菌之活性成分併入無菌媒劑中來製備分散液，該無菌媒劑含有鹼性分散介質及所需的來自以上列舉之成分的其他成分。在用於製備無菌可注射溶液之無菌散劑之情況下，某些所欲製備方法係真空乾燥及冷凍乾燥技術，其產生活性成分加來自其先前無菌過濾溶液之任何其他所欲成分的散劑。 其他醫藥組成物
醫藥組成物亦可由本文所述之組成物及一或多種醫藥上可接受之賦形劑製備，該等賦形劑適用於局部、舌下、口腔、直腸、骨內、眼內、鼻內、硬膜外、或椎管內投予。此類醫藥組成物之製備係本領域中熟知的。參見例如Anderson, Philip O.；Knoben, James E.；Troutman, William G, eds., Handbook of Clinical Drug Data, Tenth Edition, McGraw-Hill, 2002；Pratt and Taylor, eds., Principles of Drug Action, Third Edition, Churchill Livingston, New York, 1990；Katzung, ed., Basic and Clinical Pharmacology, Ninth Edition, McGraw Hill, 2004；Goodman and Gilman, eds., The Pharmacological Basis of Therapeutics, Tenth Edition, McGraw Hill, 2001；Remington’s Pharmaceutical Sciences, 20th Ed., Lippincott Williams & Wilkins., 2000；Martindale, The Extra Pharmacopoeia, Thirty-Second Edition (The Pharmaceutical Press, London, 1999)；其等全文皆以引用方式併入本文中。 本揭露之化合物之合成
本揭露之化合物可藉由所屬技術領域中闡述之一般方案、程序及實例中所描述之方法及藉由所屬技術領域中已知之相關方法來製備。例如，式 I之化合物可藉由一般方案1至11中所示之一般方法來製備。 一般方案1：式I之化合物之製備
式I之化合物經由一般方案1所描繪之反應得到。式1.1或1.2的胺與式1.3的醛首先在Pictet-Spengler反應條件下反應，以得到式1.4的核心胺。在Pictet-Spengler反應期間形成亞胺副產物的情況下，亞胺副產物可以藉由在醇溶劑（例如甲醇或乙醇）中與硼氫化鈉反應而轉化成式1.4的核心胺。然後藉由使用親核取代反應（方法A1）、Buchwald或其他類似的交叉偶合反應（方法A2）、還原胺化反應（方法B）、或醯胺偶合反應（方法C、D、E、及F）來安裝各種L及R 2基團。根據方法A1，使用在鹼性條件諸如DIPEA下之親核取代反應將式1.5的R 2芳基或雜芳基鹵化物（其中X係Br、Cl、或F）偶合至式1.4的核心胺，以得到式1.6的化合物。在方法A2中，使用所屬技術領域中已知之Buchwald偶合或交叉偶合條件，諸如使用鈀催化劑（例如CPhos-Pd-G3、Pd(OAc) 2、Pd(dppf)Cl 2）及鹼（諸如Cs 2CO 3），將式1.5的R 2芳基或雜芳基鹵化物（其中X係Br、Cl、或I）偶合至式1.4的核心胺，以得到式1.6的化合物。根據方法B，在還原胺化反應條件下，使用氫化物諸如三乙醯氧基硼氫化鈉，將式1.7的R 2芳基或雜芳基醛偶合至式1.4的核心胺，以得到式1.8的化合物。根據方法C，使用所屬技術領域中已知的酸偶合條件，諸如使用以下試劑—HOBt、EDCI、HATU、T3P中之一者以及鹼諸如DIPEA（Hunig氏鹼）、吡啶或TEA，將式1.9的R 2羧酸或其鹼性鹽（亦即Li、K、或Na）偶合至式1.4的核心胺，以得到式1.11的化合物，其中L 2係鍵、可選地經取代之C 1-6伸烷基、可選地經取代之C 2-6伸烯基、或可選地經取代之C 1-6鹵伸烷基。替代地，根據方法D，式1.10的R 2酸性氯化物在鹼性條件下偶合至式1.4的核心胺，以得到式1.11的化合物，其中L 2係鍵、可選地C 1-6伸烷基、可選地經取代之C 2-6伸烯基、或可選地經取代之C 1-6鹵伸烷基。根據方法E，式1.12的R 2酸性氯化物在鹼性條件下偶合至式1.4的核心胺，以得到式1.14的化合物，其中L 3係鍵或可選地經取代之C 1-6伸烷基。根據方法F，式1.13的R 2胺在鹼性條件下偶合至式1.4的核心胺及羰基二咪唑，以得到式1.14的化合物，其中L 3係鍵或可選地經取代之C 1-6伸烷基。 一般方案2：式2.2之氘化核心胺中間物之製備
其中R 5係D之式I之化合物根據一般方案2製備。式1.1或1.2的胺與式1.3的醛在Pictet-Spengler反應條件下反應，以得到式2.1的化合物或式2.1的化合物與式2.1a的亞胺副產物的混合物。然後，式2.1的化合物或式2.1及2.1a的化合物的混合物與硼氘化鈉在氘化甲醇中反應，以得到式2.2的氘化核心胺。然後，式2.2的氘化核心胺中間物可以經由一般方案1中描述之方法A、B、C、D、E、及F進一步偶合至各種L及R 2基團，以得到式I之化合物，其中R 5係D。 一般方案3：㗁唑基R 2酸中間物之製備
根據一般方案3製備在R 6及/或R 7位置處含有取代之㗁唑基R 2羧酸中間物。式3.1之羧酸與草醯氯及催化N,N-二甲基甲醯胺反應，以得到式3.2的酸性氯化物。然後，式3.2之酸性氯化物與式3.3之烯胺反應，以得到式3.4之烯胺。在與[雙(三氟乙醯氧基)碘]苯與三氟化硼二乙醚合物反應後，式3.4的烯胺然後經歷高價碘介導之環化，以得到式3.5的㗁唑。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式3.5㗁唑之酯，得到式3.6化合物。替代地，式3.6羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案4：㗁唑基R 2酸中間物之製備
根據一般方案4製備在R 6及/或R 7位置處含有取代之㗁唑基R 2羧酸中間物。用氯化劑諸如SOCl 2或溴化劑諸如NBS鹵化式4.1的β-酮酯，以得到式4.2的化合物（其中X 1係Br或Cl）。式4.2的化合物與脲反應，以得到式4.3的胺㗁唑化合物。此外，式4.2的化合物與式4.5的醯胺反應，以得到式4.6的㗁唑化合物。將式4.3化合物中的胺置於山德邁耳(Sandmeyer)反應條件下，以得到式4.4化合物（其中X係Cl、Br、或F）及式4.10化合物。替代地，式4.10的化合物可以藉由用鹼諸如LiHMDS將式4.8化合物去質子化，然後在親核取代反應中與式4.9的試劑（其中Y係合適的離去基，諸如Br、Cl、甲磺酸酯、或甲苯磺酸酯）反應，以得到式4.10化合物而獲得。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式4.6及4.10化合物之酯，得到式4.7及4.11化合物。替代地，式4.7及4.11羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案5：噻唑基及㗁唑基R 2酸中間物之合成
根據一般方案5製備在R 6及/或R 7位置處含有取代之㗁唑基及噻唑基R 2羧酸中間物。根據方法A，式5.1之鹵化物與式5.2之雜芳基或芳基在鈴木偶合（其中Y係硼酸或酯）或Stille偶合（其中Y係SnR 3）中反應，以得到式5.3化合物。根據方法B，藉由使式5.4化合物與式5.5之雜芳基或芳基鹵化物化合物在交叉偶合反應中，使用金屬催化劑諸如Buchwald催化劑或Ullman催化劑反應而獲得式5.3之化合物。根據方法C，式5.1之鹵化物亦可與式5.7之胺或雜環胺諸如哌啶、 啉、哌𠯤、吖呾、及吡咯啶、以及鹼諸如TEA在置換反應中反應，以得到式5.8化合物。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式5.3及5.8化合物之酯，得到式5.6及5.9化合物。替代地，式5.6及5.9羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案6：噻唑基及㗁唑基R 2酸中間物之合成
根據一般方案6製備含有羥基烷基及鹵烷基之㗁唑基及噻唑基R 2羧酸中間物。根據方法A，式6.1之鹵化物與三丁基(1-乙氧基乙烯基)錫烷在Stille偶合中反應，隨後用酸/水諸如TFA水解，以得到式6.3化合物。接著，使用RMgBr或RLi，或透過以NaBR還原酮，將烷基（「R」）添加式6.3化合物中之酮，以得到式6.4化合物。根據方法B，式6.4化合物亦可以式6.1化合物開始，藉由與式6.2的酮（其中R係烷基）或環丁酮及RMgCl諸如iPrMgCl發生格任亞加成反應而獲得。使用氟化劑諸如BAST將式6.4化合物中之羥基取代基轉化為氟取代基，以得到式6.6化合物。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式6.4及6.6化合物之酯，得到式6.5及6.7化合物。替代地，式6.5及6.7羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案7：吡唑并[1,5-a]吡啶基R 2酸中間物之合成
經取代之吡唑并[1,5-a]吡啶基R 2羧酸中間物係根據一般方案7製備。根據方法A，式7.1之鹵化物（其中X 1係Br或Cl）在C-N交叉偶合反應中，使用金屬催化劑諸如Buchwald催化劑或Ullman催化劑與式7.2之胺或雜環胺諸如哌啶、 啉、哌𠯤、吖呾、及吡咯啶反應，以得到式7.3化合物。根據方法B，式7.1（其中X 1係Br或Cl）之鹵化物亦可與式7.5之雜芳基或芳基化合物在鈴木偶合（其中Y係硼酸或酯）或Stille偶合（其中Y係SnR 3）中反應，以得到式7.6化合物。根據方法C，式7.1（其中X 1係Br或Cl）之鹵化物與4,4,5,5-四甲基-2-乙烯基-1,3,2-二氧雜硼戊環在鈴木偶合中反應，以得到式7.8化合物。式7.8化合物中之烯烴接著經歷氧化切割成醛以提供式7.9化合物。根據方法D，在醇溶劑諸如甲醇或乙醇中，用氫化物諸如NaBH 4將式7.9化合物中之醛還原成醇，以得到式7.13。用氫化鈉及式7.14（其中X係Cl、Br、或F）之烷基（「R」）鹵化物烷基化式7.13化合物中之醇，以得到式7.15化合物。根據方法E，式7.9化合物在還原胺化條件下與式7.10之胺反應，以得到式7.11化合物。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式7.3、7.6、7.11、及7.15化合物之酯，得到式7.4、7.7、7.12、及7.16化合物。替代地，式7.4、7.7、7.12、及7.16羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案8：吡唑并[1,5-a]吡啶基R 2酸中間物之合成
經二取代之吡唑并[1,5-a]吡啶基R 2羧酸中間物係根據一般方案8製備。起始試劑3-溴-4-氯吡啶與(E)-N-((均三甲苯基磺醯基)氧基)亞胺逐乙酸乙基酯反應，以得到N-胺基吡啶鎓鹽8.1。N-胺基吡啶鎓鹽8.1與丙炔酸乙酯及鹼諸如K 2CO 3之環加成反應得到6-溴-5-氯吡唑并[1,5-a]吡啶-3-羧酸乙基酯8.2。化合物8.2在C-N交叉偶合反應中，使用金屬催化劑諸如Buchwald催化劑或Ullman催化劑與式8.4之胺或雜環胺諸如哌啶、 啉、哌𠯤、吖呾、及吡咯啶反應，以得到式8.5化合物。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式8.2及8.5化合物之酯，得到式8.3及8.6化合物。替代地，式8.3及8.6羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案9：1,3,4-㗁二唑基R 2酸中間物之合成
雜芳基及芳基取代之㗁二唑基R 2羧酸中間物係根據一般方案9製備。根據方法A，式9.1之雜芳基及芳基酯與肼水合物反應，以得到式9.2之肼。然後使式9.2化合物與乙基-2-氯-2-側氧基乙酸酯反應，以得到式9.3化合物，隨後用對甲苯磺醯氯及鹼諸如TEA對該化合物進行分子內環化，以得到式9.4之1,3,4-㗁二唑。替代地，可使用方法B製備式9.4化合物。根據方法B，使2-肼基-2-側氧基乙酸乙基酯與1,1'-硫代羰基二咪唑反應，以形成1,3,4-㗁二唑，其接著用碘甲烷及鹼諸如TEA烷基化，以得到5-(甲硫基)-1,3,4-㗁二唑-2-羧酸乙基酯。使5-(甲硫基)-1,3,4-㗁二唑-2-羧酸乙基酯與式9.5之雜芳基或芳基硼酸或酯在去磺醯化C-C交叉偶合反應（亦稱為Liebeskind-Srogl交叉偶合）中反應，以得到式9.4化合物。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式9.4化合物之酯，得到式9.6化合物。替代地，式9.6羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案10：1,3,4-㗁二唑基R 2酸中間物之合成
經取代之1,3,4-㗁二唑基R 2羧酸中間物係根據一般方案10製備。使起始試劑5-胺基-1,3,4-㗁二唑-2-羧酸乙基酯經受山德邁耳反應條件，以得到5-溴-1,3,4-㗁二唑-2-羧酸乙基酯（化合物10.1）。化合物10.1中之溴基與式10.2之胺或雜環胺諸如哌啶、 啉、哌𠯤、吖呾、及吡咯啶、以及鹼諸如TEA反應，以得到式10.3化合物。用鹼諸如LiOH、KOH、或NaOH在THF/水中水解式10.3化合物之酯，得到式10.4化合物。替代地，式10.4羧酸之鹼性鹽（亦即Li、K、或Na）可以在水解反應後藉由在鹼性pH下單離產物而獲得。然後，羧酸或其鹼性鹽無需進一步純化即可用於一般方案1方法C中描述之偶合反應中。 一般方案11：式11.6及11.7之氘化核心胺中間物之製備
其中R 5A係D之式I之化合物根據一般方案11製備。用BOC保護基或其他合適的氮保護基保護根據一般方案2製備之式2.1之胺，以得到式11.1化合物。然後用二甲基胺磺醯基保護基保護式11.1中之胺，以得到式11.2及11.3化合物之混合物，該等化合物在純化期間被分離。然後藉由用丁基鋰將式11.2化合物去質子化，然後添加D 2O，在R 5A位置處併入氘，以得到式11.4及11.5化合物。用酸將氮保護基去保護，得到式11.6之氘化核心胺中間物。式11.6的氘化核心胺中間物可以經由一般方案1中描述之方法A、B、C、D、E、及F進一步偶合至各種L及R 2基團，以得到式I之化合物，其中R 5A係D。
藉由參考以下實例將更充分地理解本揭露。本文提供之實例係說明性的，然而不應被解釋為限制本揭露之範疇。 實例
在一些實施例中，本揭露提供式I之特定實例、及其醫藥上可接受之鹽及/或類同位素分子，如下表1中所闡述。
表1 ：吡唑并[1,5-a] 吡啶
實例# 結構 名稱
600 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
601 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
602 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(噻唑-5-基)甲酮
603 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(噻唑-5-基)甲酮
604 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
605 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
606 (S)-(4-甲基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
607 (R)-(4-甲基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
608 (S)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-2-(4-(三氟甲基)噻唑-2-基)乙酮
609 (R)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-2-(4-(三氟甲基)噻唑-2-基)乙酮
610 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
611 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
612 (S)-(2-(1,1-二氟乙基)噻唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
613 (R)-(2-(1,1-二氟乙基)噻唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
614 (S)-2-環丙基-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
615 (R)-2-環丙基-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
616 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
617 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
618 (S)-(4-環丙基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
619 (R)-(4-環丙基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
620 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
621 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
622 (S)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
623 (R)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
624 (S)-(4-環丙基-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
625 (R)-(4-環丙基-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
626 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
627 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
628 (S)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
629 (R)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
630 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
631 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
632 (S)-(2-環丙基-4-(二氟甲基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
633 (R)-(2-環丙基-4-(二氟甲基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
634 (S)-2-(1-羥基環丁基)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
635 (R)-2-(1-羥基環丁基)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
636 (S)-2-(3-氟環丁基)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙烯酮
637 (R)-2-(3-氟環丁基)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
638 (S)-2,2-二氟-2-(1-羥基環丁基)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
639 (R)-2,2-二氟-2-(1-羥基環丁基)-1-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)乙酮
640 (S)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
641 (R)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
642 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(4-(三氟甲基)苯基)-1,3,4-㗁二唑-2-基)甲酮
643 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(4-(三氟甲基)苯基)-1,3,4-㗁二唑-2-基)甲酮
644 (S)-(4-(二氟甲基)-2-(吡啶-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
645 (R)-(4-(二氟甲基)-2-(吡啶-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
646 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(2,2,2-三氟乙基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
647 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(2,2,2-三氟乙基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
648 (S)-(5-(3,4-二氟苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
649 (R)-(5-(3,4-二氟苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
650 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
651 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
652 (S)-(5-(2,4-二氟苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
653 (R)-(5-(2,4-二氟苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
654 (S)-(5-(4-氟-2-甲基苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
655 (R)-(5-(4-氟-2-甲基苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
656 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
657 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
658 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
659 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
660 (S)-(1-甲基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
661 (R)-(1-甲基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
662 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
663 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
664 (R)-(3-氯-1-甲基-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
665 (S)-(3-氯-1-甲基-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
666 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
667 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
668 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(4-(三氟甲基)吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
669 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(4-(三氟甲基)吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
670 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
671 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
672 (R)-(5-(5-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
673 (S)-(5-(5-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
674 (S)-(3-氯-1-(吡啶-2-基)-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
675 (R)-(3-氯-1-(吡啶-2-基)-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
676 (S)-(4-溴-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
677 (R)-(4-溴-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
678 (S)-(5-(1-甲基-3-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
679 (R)-(5-(1-甲基-3-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
680 (S)-(3-氯-1-甲基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
681 (R)-(3-氯-1-甲基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
682 (S)-5-(4-(6-溴吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
683 (R)-5-(4-(6-溴吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
684 (S)-5-(4-(6-氯吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
685 (R)-5-(4-(6-氯吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
686 (S)-5-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
687 (R)-5-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
688 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
689 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
690 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((S)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
691 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((R)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
692 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((S)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
693 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((R)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
694 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
695 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
696 (S)-(4-(6-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
697 (R)-(4-(6-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
698 (R)-2-(4-(二氟甲基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-2-基)-2-甲基丙腈
699 (S)-2-(4-(二氟甲基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-2-基)-2-甲基丙腈
700 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
701 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
702 ((S)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)甲酮
703 ((R)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)甲酮
704 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)甲酮
705 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)甲酮
706 ((S)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((R)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
707 ((R)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((R)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
708 ((S)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
709 ((R)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
710 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
711 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
712 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
713 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
714 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
715 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
716 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(三氟甲基)-1H-吡唑-5-基)甲酮
717 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(三氟甲基)-1H-吡唑-5-基)甲酮
718 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
719 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
720 (S)-(4-氯-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
721 (R)-(4-氯-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
722 (S)-(4-溴-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
723 (R)-(4-溴-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
724 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)甲酮
725 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)甲酮
726 ((S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((R)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
727 ((R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((R)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
728 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
729 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
730 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
731 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
732 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
733 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
734 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
735 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
736 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
737 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
738 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
739 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
740 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
741 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
742 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
743 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
744 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)甲酮
745 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)甲酮
746 (S)-(4-溴-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
747 (R)-(4-溴-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
748 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
749 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
750 (2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)((S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
751 (2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)((R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
752 (2-((R)-1-羥基乙基)-4-甲基㗁唑-5-基)((S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
753 (2-((R)-1-羥基乙基)-4-甲基㗁唑-5-基)((R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
754 (S)-(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
755 (R)-(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
756 (S)-(4-氯-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
757 (R)-(4-氯-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
758 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
759 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
760 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
761 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
762 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
763 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
764 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
765 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
766 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
767 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
768 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
769 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
770 (S)-(4-甲基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
771 (R)-(4-甲基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
772 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
773 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
774 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-甲基㗁唑-5-基)甲酮
775 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-甲基㗁唑-5-基)甲酮
776 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
777 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
778 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
779 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
780 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)甲酮
781 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)甲酮
782 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(二氟甲基)-1H-吡唑-5-基)甲酮
783 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(二氟甲基)-1H-吡唑-5-基)甲酮
784 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(3-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
785 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(3-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
786 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(3-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
787 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(3-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
788 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
789 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
790 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
791 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
792 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
793 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
794 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
795 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
796 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
797 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
798 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
799 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
800 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
801 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
802 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
803 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
804 (S)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
805 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
806 (S)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
807 (R)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
808 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
809 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
810 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
811 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
812 (S)-(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
813 (R)-(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
814 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
815 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
816 (R)-(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
817 (S)-(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
818 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
819 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
820 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
821 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
822 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
823 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
824 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
825 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
826 (S)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
827 (R)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
828 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
829 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
830 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-4-基)甲酮
831 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-4-基)-1,3,4-㗁二唑-2-基)甲酮
832 (S)-(5-(1-環丁基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
833 (R)-(5-(1-環丁基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
834 (S)-(5-(1-(環丙基磺醯基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
835 (R)-(5-(1-(環丙基磺醯基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
836 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
837 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
838 (S)-(1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
839 (R)-(1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
840 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-1H-1,2,4-三唑-5-基)甲酮
841 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-1H-1,2,4-三唑-5-基)甲酮
842 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(三氟甲基)-1H-吡唑-5-基)甲酮
843 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(三氟甲基)-1H-吡唑-5-基)甲酮
844 (S)-(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
845 (R)-(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
846 (S)-(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
847 (R)-(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
848 (S)-(1-環丙基-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
849 (R)-(1-環丙基-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
850 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-4-基)-1,3,4-㗁二唑-2-基)甲酮
851 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-4-基)-1,3,4-㗁二唑-2-基)甲酮
852 (S)-(5-(1-(環丙基磺醯基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
853 (R)-(5-(1-(環丙基磺醯基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
854 (S)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
855 (R)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
856 (S)-(1-異丙基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
857 (R)-(1-異丙基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
858 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-異丙基-1H-吡唑-5-基)甲酮
859 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-異丙基-1H-吡唑-5-基)甲酮
860 (S)-(1-環丙基-1H-吡唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
861 (R)-(1-環丙基-1H-吡唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
862 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(吡啶-2-基)-1H-吡唑-5-基)甲酮
863 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(吡啶-2-基)-1H-吡唑-5-基)甲酮
864 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
865 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
866 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
867 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
868 (R)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-5-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
869 (S)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-5-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
870 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
871 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
872 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-(三氟甲基)吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
873 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-(三氟甲基)吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
874 (R)-(5-(5-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
875 (S)-(5-(5-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
876 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
877 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
878 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-(三氟甲基)吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
879 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-(三氟甲基)吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
880 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
881 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
882 (R)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
883 (S)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
884 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-1H-吡唑-5-基)甲酮
885 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-1H-吡唑-5-基)甲酮
886 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
887 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
888 (R)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-5-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
889 (S)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-5-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
890 (R)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-5-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
891 (S)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-5-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
892 (S)-(1,3-二甲基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
893 (R)-(1,3-二甲基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
894 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
895 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
896 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
897 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
898 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(吡啶-2-基)-1H-吡唑-5-基)甲酮
899 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(吡啶-2-基)-1H-吡唑-5-基)甲酮
900 (S)-(1,3-二甲基-1H-吡唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
901 (R)-(1,3-二甲基-1H-吡唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
902 (S)-(4-(二氟甲基)-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
903 (R)-(4-(二氟甲基)-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
904 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
905 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
906 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
907 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
908 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
909 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
910 (S)-(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
911 (R)-(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
912 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
913 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
914 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
915 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
916 (S)-(1,3-二甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
917 (R)-(1,3-二甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
918 (S)-(1,3-二甲基-1H-吡唑-5-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
919 (R)-(1,3-二甲基-1H-吡唑-5-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
920 (R)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
921 (S)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
922 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
923 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
924 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
925 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
926 (S)-(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
927 (R)-(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
928 (S)-(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
929 (R)-(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
930 (R)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
931 (S)-(4-(二氟甲基)-2-(1-甲基-1H-咪唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
932 (S)-(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
933 (R)-(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
934 (S)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
935 (R)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
936 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
937 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
938 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
939 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
940 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
941 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
942 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
943 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
944 (S)-(5-甲基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
945 (R)-(5-甲基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
946 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
947 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
948 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
949 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
950 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
951 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
952 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
953 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
954 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
955 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
956 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
957 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
958 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)㗁唑-5-基)甲酮
959 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)㗁唑-5-基)甲酮
960 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
961 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
962 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
963 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
964 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
965 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
966 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
967 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
968 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
969 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
970 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
971 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
972 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
973 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
974 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
975 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
976 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
977 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
978 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
979 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
980 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
981 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
982 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
983 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
984 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
985 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
986 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
987 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
988 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
989 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
990 (S)-(4-氯-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
991 (R)-(4-氯-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
992 (S)-2-甲基-2-(4-甲基-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-2-基)丙腈
993 (R)-2-甲基-2-(4-甲基-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-2-基)丙腈
994 (S)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
995 (R)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
996 (4-溴-2-(1-羥基乙基)㗁唑-5-基)((S)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#1 (Rt=5.586 min)
997 (4-溴-2-(1-羥基乙基)㗁唑-5-基)((S)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#2 (Rt=5.796 min)
998 (4-溴-2-(1-羥基乙基)㗁唑-5-基)((R)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#1 (Rt=4.830 min)
999 (4-溴-2-(1-羥基乙基)㗁唑-5-基)((R)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#2 (Rt=5.133 min)
1000 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)甲酮
1001 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)甲酮
1002 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1003 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1004 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1005 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1006 (S)-(4-(二氟甲基)-2-(吡啶-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1007 (R)-(4-(二氟甲基)-2-(吡啶-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1008 (S)-(4-(二氟甲基)-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1009 (R)-(4-(二氟甲基)-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1010 (S)-(5-甲基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1011 (R)-(5-甲基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1012 (S)-(5-(4-氟哌啶-1-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1013 (R)-(5-(4-氟哌啶-1-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1014 (S)-(5-(4-氟哌啶-1-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1015 (R)-(5-(4-氟哌啶-1-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1016 (S)-(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1017 (R)-(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1018 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1019 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1020 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1021 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1022 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1023 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1024 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1025 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1026 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1027 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1028 (S)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1029 (R)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1030 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1031 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1032 (S)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1033 (R)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1034 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1035 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1036 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1037 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1038 (S)-(5-(1-環丁基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1039 (R)-(5-(1-環丁基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1040 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1041 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1042 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1043 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1044 (S)-(1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1045 (R)-(1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1046 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1047 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1048 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1049 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1050 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-1H-1,2,4-三唑-5-基)甲酮
1051 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-1H-1,2,4-三唑-5-基)甲酮
1052 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)甲酮
1053 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)甲酮
1054 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1055 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1056 (S)-(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1057 (R)-(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1058 (S)-(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1059 (R)-(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1060 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1061 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1062 (S)-(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1063 (R)-(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1064 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(二氟甲基)-1H-吡唑-5-基)甲酮
1065 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(二氟甲基)-1H-吡唑-5-基)甲酮
1066 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1067 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1068 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1069 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1070 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1071 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1072 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)甲酮
1073 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)甲酮
1074 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1,3-二甲基-1H-1,2,4-三唑-5-基)甲酮
1075 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1,3-二甲基-1H-1,2,4-三唑-5-基)甲酮
1076 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1077 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1078 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1079 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1080 (R)-(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1081 (S)-(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1082 (S)-(1,3-二甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1083 (R)-(1,3-二甲基-1H-1,2,4-三唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1084 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1085 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1086 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1087 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1088 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1089 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1090 (S)-(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1091 (R)-(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1092 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1093 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1094 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丙基-1,3,4-㗁二唑-2-基)甲酮
1095 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丙基-1,3,4-㗁二唑-2-基)甲酮
1096 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1097 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1098 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1099 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1100 (S)-(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1101 (R)-(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1102 (S)-(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1103 (R)-(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1104 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1105 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1106 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
1107 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
1108 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1109 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1110 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1111 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1112 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1113 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1114 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1115 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1116 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1117 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1118 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1119 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1120 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1121 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1122 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1123 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1124 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1125 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1126 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1127 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1128 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1129 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1130 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1131 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1132 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1133 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1134 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1135 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1136 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丙基-1,3,4-㗁二唑-2-基)甲酮
1137 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丙基-1,3,4-㗁二唑-2-基)甲酮
1138 (S)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1139 (R)-(1-(二氟甲基)-1H-吡唑-5-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1140 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1141 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1142 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1143 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1144 (S)-(1-甲基-1H-1,2,4-三唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1145 (R)-(1-甲基-1H-1,2,4-三唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1146 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
1147 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
1148 (S)-(4-甲基㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1149 (R)-(4-甲基㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1150 (S)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1151 (R)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1152 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((S)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1153 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((R)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1154 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1155 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1156 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1157 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1158 (S)-㗁唑-5-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1159 (R)-㗁唑-5-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1160 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1161 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1162 (S)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1163 (R)-(3-氯-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1164 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((S)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1165 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((R)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1166 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
1167 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
1168 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1169 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1170 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1171 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1172 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
1173 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(三氟甲基)㗁唑-5-基)甲酮
1174 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-甲基㗁唑-5-基)甲酮
1175 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-甲基㗁唑-5-基)甲酮
1176 (S)-(4-(三氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1177 (R)-(4-(三氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1178 (S)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1179 (R)-(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1180 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((S)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1181 (4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)((R)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1182 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1183 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1184 (R)-(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
1185 (S)-(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
1186 (R)-(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
1187 (S)-(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(㗁唑-5-基)甲酮
1188 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1189 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1190 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1191 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1192 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)甲酮
1193 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-(三氟甲基)㗁唑-5-基)甲酮
1194 ((R)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)甲酮
1195 ((S)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)甲酮
1196 ((S)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)甲酮
1197 ((R)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-((R)-1-羥基乙基)㗁唑-5-基)甲酮
1198 (S)-(4-(三氟甲基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1199 (R)-(4-甲基㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1200 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((S)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1201 (4-(二氟甲基)-2-((S)-1-羥基乙基)㗁唑-5-基)((R)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1202 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1203 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1204 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1205 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1206 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1207 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1208 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1209 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1210 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)甲酮
1211 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)-4-甲基㗁唑-5-基)甲酮
1212 ((S)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
1213 ((R)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)甲酮
1214 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1215 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1216 (S)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1217 (R)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1218 (S)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1219 (R)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1220 (S)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1221 (R)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1222 (S)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1223 (R)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1224 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1225 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1226 (S)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1227 (R)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1228 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)甲酮
1229 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)甲酮
1230 (S)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1231 (R)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1232 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)甲酮
1233 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)甲酮
1234 (S)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1235 (R)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1236 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)甲酮
1237 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)甲酮
1238 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1239 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1240 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(7-乙氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1241 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(7-乙氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1242 (S)-(4-(7-乙氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1243 (R)-(4-(7-乙氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1244 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-乙氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1245 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(7-乙氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1246 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1247 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1248 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1249 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1250 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1251 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1252 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1253 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1254 (R)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1255 (S)-(4-(二氟甲基)-2-(2-氟丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1256 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1257 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1258 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-4-基)甲酮
1259 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-4-基)-1,3,4-㗁二唑-2-基)甲酮
1260 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1261 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1262 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1263 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1264 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1265 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1266 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)甲酮
1267 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)甲酮
1268 (S)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1269 (R)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1270 (S)-吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1271 (R)-吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1272 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1273 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1274 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1275 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1276 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)甲酮
1277 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)甲酮
1278 (S)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1279 (R)-(2-(2-氟丙-2-基)-4-甲基㗁唑-5-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1280 (S)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1281 (R)-(4-(二氟甲基)-2-(1-羥基環丙基)㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1282 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
1283 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
1284 (S)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1285 (R)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1286 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1287 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1288 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1289 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1290 (R)-2-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1291 (S)-2-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1292 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1293 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1294 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1295 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1296 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)甲酮
1297 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)甲酮
1298 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1299 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1300 (S)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1301 (R)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1302 (S)-(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1303 (R)-(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1304 (S)-(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1305 (R)-(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1306 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1307 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1308 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1309 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1310 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1311 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1312 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1313 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1314 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1315 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1316 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1317 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1318 (R)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1319 (S)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1320 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)甲酮
1321 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)甲酮
1322 (R)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1323 (S)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1324 (R)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1325 (S)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1326 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1327 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1328 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1329 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1330 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1331 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1332 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1333 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1334 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1335 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1336 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1337 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1338 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1339 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1340 (S)-(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1341 (R)-(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1342 (S)-(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1343 (R)-(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1344 (S)-(5-(6-甲氧基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1345 (R)-(5-(6-甲氧基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1346 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1347 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1348 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1349 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1350 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1351 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1352 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1353 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1354 (S)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1355 (R)-(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1356 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1357 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1358 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1359 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1360 (R)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1361 (S)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1362 (S)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1363 (R)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1364 (S)-(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1365 (R)-(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1366 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1367 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1368 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)甲酮
1369 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)甲酮
1370 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1371 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1372 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1373 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1374 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1375 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1376 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1377 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1378 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)甲酮
1379 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基環丙基)-1,3,4-㗁二唑-2-基)甲酮
1380 (R)-(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1381 (S)-(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1382 (S)-(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1383 (R)-(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1384 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)甲酮
1385 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)甲酮
1386 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1387 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1388 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1389 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1390 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1391 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1392 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1393 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1394 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1395 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1396 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1397 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1398 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1399 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1400 (S)-(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1401 (R)-(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1402 (S)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1403 (R)-(3-(二氟甲基)-1-甲基-1H-吡唑-5-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1404 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1405 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1406 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1407 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1408 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1409 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1410 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1411 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1412 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1413 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1414 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1415 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1416 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1417 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1418 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1419 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1420 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1421 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1422 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1423 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1424 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1425 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1426 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1427 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1428 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1429 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1430 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1431 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1432 (R)-(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1433 (S)-(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1434 (S)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1435 (R)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1436 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1437 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1438 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1439 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1440 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1441 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1442 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1443 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1444 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1445 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1446 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1447 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1448 (S)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1449 (R)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1450 (S)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1451 (R)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1452 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1453 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1454 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-環丙基-1,3,4-㗁二唑
1455 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-環丙基-1,3,4-㗁二唑
1456 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1457 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1458 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1459 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1460 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1461 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1462 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1463 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1464 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1465 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1466 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1467 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1468 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1469 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1470 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1471 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1472 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1473 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1474 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1475 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1476 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1477 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1478 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1479 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1480 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1481 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1482 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1483 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1484 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1485 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1486 (S)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1487 (R)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1488 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1489 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1490 (S)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1491 (R)-(5-異丙基-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1492 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1493 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1494 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1495 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1496 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1497 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1498 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1499 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1500 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1501 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1502 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1503 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1504 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1505 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1506 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1507 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1508 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1509 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1510 (S)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1511 (R)-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1512 (S)-(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1513 (R)-(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1514 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1515 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1516 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丁基-1,3,4-㗁二唑-2-基)甲酮
1517 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丁基-1,3,4-㗁二唑-2-基)甲酮
1518 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1519 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1520 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1521 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1522 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1523 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-3-基)-1,3,4-㗁二唑-2-基)甲酮
1524 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1525 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1526 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1527 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1528 (S)-(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1529 (R)-(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1530 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1531 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1532 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1533 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1534 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1535 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1536 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1537 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1538 (S)-(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1539 (R)-(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1540 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1541 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1542 (S)-(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1543 (R)-(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1544 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1545 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1546 (S)-(6-((二甲胺基)甲基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1547 (R)-(6-((二甲胺基)甲基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1548 (S)-(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1549 (R)-(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1550 (S)-(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1551 (R)-(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1552 (S)-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1553 (R)-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1554 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1555 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-異丙基-1,3,4-㗁二唑-2-基)甲酮
1556 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1557 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1558 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1559 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1560 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丁基-1,3,4-㗁二唑-2-基)甲酮
1561 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-環丁基-1,3,4-㗁二唑-2-基)甲酮
1562 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1563 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1564 (R)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1565 (S)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1566 (S)-(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1567 (R)-(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1568 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1569 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1570 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1571 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1572 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1573 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1574 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1575 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1576 (R)-2-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)苯并[d]㗁唑
1577 (S)-2-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)苯并[d]㗁唑
1578 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1579 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(5-甲氧基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1580 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1581 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1582 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1583 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,3-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1584 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1585 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,4-二甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1586 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)甲酮
1587 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)甲酮
1588 (R)-2-環丙基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1589 (S)-2-環丙基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1590 (R)-2-環丙基-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1591 (S)-2-環丙基-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1592 (S)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1593 (R)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1594 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1595 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1596 (S)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1597 (R)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1598 (S)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1599 (R)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1600 (S)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1601 (R)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1602 (S)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1603 (R)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1604 (S)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1605 (R)-(5-(3,3-二氟環丁基)-1,3,4-㗁二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1606 (R)-2-環丙基-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1607 (S)-2-環丙基-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1608 (S)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1609 (R)-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)甲酮
1610 (S)-2-(吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1611 (R)-2-(吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1612 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1613 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1614 (S)-(6- 啉吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1615 (R)-(6- 啉吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1616 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1617 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1618 (S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1619 (R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1620 (R)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1621 (S)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1622 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1623 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1624 (S)-(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1625 (R)-(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1626 (S)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1627 (R)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1628 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
1629 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
1630 (S)-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1631 (R)-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1632 (S)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1633 (R)-(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1634 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-((二甲胺基)甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
1635 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-((二甲胺基)甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
1636 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1637 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1638 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1639 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1640 (S)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1641 (R)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(吡啶-2-基)-1,3,4-㗁二唑
1642 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)苯并[d]㗁唑
1643 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)苯并[d]㗁唑
1644 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1645 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1646 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1647 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1648 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1649 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1650 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
1651 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
1652 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1653 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1654 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1655 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1656 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1657 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1658 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1659 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1660 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1661 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1662 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1663 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1664 (S)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1665 (R)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1666 (S)-(6-甲基吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1667 (R)-(6-甲基吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1668 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1669 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1670 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1671 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1672 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1673 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1674 (S)-(6-甲氧基吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1675 (R)-(6-甲氧基吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1676 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1677 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1678 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1679 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1680 (S)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1681 (R)-(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1682 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1683 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1684 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1685 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1686 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1687 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1688 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1689 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1690 (S)-(6-((二甲胺基)甲基)吡唑并[1,5-a]吡啶-3-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1691 (R)-(6-((二甲胺基)甲基)吡唑并[1,5-a]吡啶-3-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1692 (S)-5-(嘧啶-2-基)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1693 (R)-5-(嘧啶-2-基)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1694 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1695 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1696 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1697 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1698 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1699 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1700 (R)-5-(吡𠯤-2-基)-4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1701 (S)-5-(吡𠯤-2-基)-4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1702 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1703 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1704 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1705 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1706 (S)-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1707 (R)-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1708 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1709 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1710 (R)-2-(二氟甲基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1711 (S)-2-(二氟甲基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1712 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1713 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1714 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1715 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1716 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1717 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1718 (S)-(6-甲氧基吡唑并[1,5-a]吡啶-3-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1719 (R)-(6-甲氧基吡唑并[1,5-a]吡啶-3-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1720 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1721 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
1722 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1723 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1724 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1725 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1726 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1727 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1728 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1729 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1730 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1731 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
1732 (R)-2-(二氟甲基)-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1733 (S)-2-(二氟甲基)-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1734 (R)-2-(二氟甲基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1735 (S)-2-(二氟甲基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1736 (R)-2-(二氟甲基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1737 (S)-2-(二氟甲基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1738 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(二氟甲基)-1,3,4-㗁二唑
1739 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(二氟甲基)-1,3,4-㗁二唑
1740 (R)-2-(二氟甲基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1741 (S)-2-(二氟甲基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1742 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1743 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1744 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-環丙基吡唑并[1,5-a]吡啶-3-基)甲酮
1745 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-環丙基吡唑并[1,5-a]吡啶-3-基)甲酮
1746 (S)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1747 (R)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1748 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1749 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(1-甲基-1H-吡唑-3-基)吡唑并[1,5-a]吡啶-3-基)甲酮
1750 (S)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1751 (R)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1752 (S)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1753 (R)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1754 (S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1755 (R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1756 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1757 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1758 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1759 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1760 (S)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1761 (R)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1762 (S)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1763 (R)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1764 (R)-5-(嘧啶-2-基)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1765 (S)-5-(嘧啶-2-基)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1766 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1767 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1768 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-環丙基吡唑并[1,5-a]吡啶-3-基)甲酮
1769 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-環丙基吡唑并[1,5-a]吡啶-3-基)甲酮
1770 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)甲酮
1771 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)甲酮
1772 (S)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1773 (R)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1774 (S)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1775 (R)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1776 (S)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1777 (R)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1778 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1779 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1780 (S)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1781 (R)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1782 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1783 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1784 (S)-(6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1785 (R)-(6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1786 (S)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1787 (R)-(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
1788 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1789 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1790 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1791 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(7-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1792 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)甲酮
1793 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)甲酮
1794 (S)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1795 (R)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
1796 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-基)甲酮
1797 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-基)甲酮
1798 (R)-2-(三級丁基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1799 (S)-2-(三級丁基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1800 (S)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1801 (R)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1802 (S)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1803 (R)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1804 (R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1805 (S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1806 (R)-2-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1807 (S)-2-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1808 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1809 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1810 (S)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1811 (R)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1812 (S)-4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1813 (R)-4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1814 (S)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1815 (R)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1816 (R)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1817 (S)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1818 (R)-5-(吡𠯤-2-基)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1819 (S)-5-(吡𠯤-2-基)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1820 (R)-2-(三氟甲基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1821 (S)-2-(三氟甲基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1822 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1823 ((S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1824 (R)-2-(三級丁基)-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1825 (S)-2-(三級丁基)-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1826 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)嘧啶-5-胺
1827 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)嘧啶-5-胺
1828 (R)-5-(6-氯吡𠯤-2-基)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1829 (S)-5-(6-氯吡𠯤-2-基)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1830 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-環丁基-1,3,4-㗁二唑
1831 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-環丁基-1,3,4-㗁二唑
1832 (R)-2-(三級丁基)-5-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1833 (S)-2-(三級丁基)-5-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1834 (R)-2-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1835 (S)-2-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1836 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1837 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1838 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1839 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1840 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1841 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1842 (R)-2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1843 (S)-2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1844 (R)-2-(2,6-二氟苯基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1845 (S)-2-(2,6-二氟苯基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1846 (R)-2-(2,6-二氟苯基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1847 (S)-2-(2,6-二氟苯基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
1848 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1849 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1850 (S)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1851 (R)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
1852 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1853 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1854 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1855 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1856 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1857 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1858 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
1859 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
1860 (R)-2-(4-氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1861 (S)-2-(4-氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1862 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
1863 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
1864 (R)-2-(2,6-二氟苯基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1865 (S)-2-(2,6-二氟苯基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1866 (S)-(2-(三級丁基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1867 (R)-(2-(三級丁基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1868 (S)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1869 (R)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1870 (S)-5-(吡啶-2-基)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1871 (R)-5-(吡啶-2-基)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1872 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1873 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)嘧啶-5-胺
1874 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1875 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1876 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1877 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1878 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1879 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1880 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1881 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1882 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1883 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1884 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1885 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1886 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1887 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1888 (R)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1889 (S)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1890 (R)-2-(4-氟苯基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1891 (S)-2-(4-氟苯基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1892 (R)-2-(4-氟苯基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1893 (S)-2-(4-氟苯基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1894 (R)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1895 (S)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1896 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1897 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1898 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1899 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1900 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1901 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1902 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1903 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1904 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1905 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1906 (S)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1907 (R)-(5-(3-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1908 (S)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-環丙基-1,3,4-㗁二唑-2-基)甲酮
1909 (R)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-環丙基-1,3,4-㗁二唑-2-基)甲酮
1910 (R)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1911 (S)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1912 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
1913 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
1914 (S)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1915 (R)-4-(吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1916 (S)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1917 (R)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1918 (S)-(2-環丙基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1919 (R)-(2-環丙基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1920 (S)-(2-(三級丁基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1921 (R)-(2-(三級丁基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1922 (S)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1923 (R)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1924 (S)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1925 (R)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1926 (R)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1927 (S)-(4-(4-乙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1928 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1929 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1930 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1931 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1932 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1933 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1934 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1935 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
1936 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1937 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1938 (S)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1939 (R)-(4-(4-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
1940 (R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1941 (S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1942 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1943 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1944 (S)-(4-環丙基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1945 (R)-(4-環丙基㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1946 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1947 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
1948 (S)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1949 (R)-(5-(1,5-二甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1950 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1951 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1952 (R)-2-(4-氟苯基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1953 (S)-2-(4-氟苯基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
1954 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(6-氟吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1955 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(6-氟吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1956 (R)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1957 (S)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1958 (R)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1959 (S)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1960 (S)-(2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1961 (R)-(2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1962 (S)-(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1963 (R)-(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1964 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡啶-2-基)㗁唑-5-基)甲酮
1965 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡啶-2-基)㗁唑-5-基)甲酮
1966 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-噻二唑-2-基)甲酮
1967 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-噻二唑-2-基)甲酮
1968 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-噻二唑-2-基)甲酮
1969 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-噻二唑-2-基)甲酮
1970 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-噻二唑-2-基)甲酮
1971 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(吡啶-2-基)-1,3,4-噻二唑-2-基)甲酮
1972 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(嘧啶-5-基)-1,3,4-㗁二唑-2-基)甲酮
1973 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(嘧啶-5-基)-1,3,4-㗁二唑-2-基)甲酮
1974 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(嘧啶-5-基)-1,3,4-㗁二唑-2-基)甲酮
1975 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(嘧啶-5-基)-1,3,4-㗁二唑-2-基)甲酮
1976 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1977 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1978 (R)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1979 (S)-4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
1980 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1981 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
1982 (R)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1983 (S)-(5-(1-(二氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1984 (S)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1985 (R)-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-(三氟甲基)-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
1986 (S)-(4-環丙基㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1987 (R)-(4-環丙基㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1988 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(㗁唑-2-基)甲酮
1989 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(㗁唑-2-基)甲酮
1990 (R)-(5-環丙基-1,3,4-噻二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1991 (S)-(5-環丙基-1,3,4-噻二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1992 (R)-(5-環丙基-1,3,4-噻二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1993 (S)-(5-環丙基-1,3,4-噻二唑-2-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1994 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-噻二唑-2-基)甲酮
1995 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-3-基)-1,3,4-噻二唑-2-基)甲酮
1996 (R)-(5-環丙基-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1997 (S)-(5-環丙基-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1998 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
1999 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2000 (S)-苯并[d]噻唑-2-基(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2001 (R)-苯并[d]噻唑-2-基(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2002 (S)-苯并[d]噻唑-2-基(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2003 (R)-苯并[d]噻唑-2-基(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2004 (S)-(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2005 (R)-(5-(1-甲基-1H-吡唑-5-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2006 (R)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2007 (S)-(5-(1,5-二甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2008 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
2009 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
2010 (S)-2-(4-氟苯基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2011 (R)-2-(4-氟苯基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2012 (R)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2013 (S)-4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2014 (S)-(4-環丙基㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2015 (R)-(4-環丙基㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2016 (S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-噻二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2017 (R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-噻二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2018 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-噻二唑-2-基)甲酮
2019 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-噻二唑-2-基)甲酮
2020 (S)-苯并[d]㗁唑-2-基(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2021 (R)-苯并[d]㗁唑-2-基(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2022 (S)-苯并[d]噻唑-2-基(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2023 (R)-苯并[d]噻唑-2-基(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2024 (S)-環丙基(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2025 (R)-環丙基(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2026 ((R)-2,2-二氟環丙基)((R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2027 ((R)-2,2-二氟環丙基)((S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2028 ((S)-2,2-二氟環丙基)((S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2029 ((S)-2,2-二氟環丙基)((R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2030 ((S)-2,2-二氟環丙基)((S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2031 ((S)-2,2-二氟環丙基)((R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2032 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡啶-2-基)㗁唑-5-基)甲酮
2033 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡啶-2-基)㗁唑-5-基)甲酮
2034 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡啶-2-基)㗁唑-5-基)甲酮
2035 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡啶-2-基)㗁唑-5-基)甲酮
2036 (S)-(2-(吡啶-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2037 (R)-(2-(吡啶-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2038 (R)-(4-環丙基㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2039 (S)-(4-環丙基㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2040 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(4-環丙基㗁唑-5-基)甲酮
2041 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(4-環丙基㗁唑-5-基)甲酮
2042 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(4-環丙基㗁唑-5-基)甲酮
2043 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(4-環丙基㗁唑-5-基)甲酮
2044 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-噻二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2045 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-噻二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2046 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2047 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2048 (S)-苯并[d]㗁唑-2-基(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2049 (R)-苯并[d]㗁唑-2-基(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2050 (S)-苯并[d]㗁唑-2-基(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2051 (R)-苯并[d]㗁唑-2-基(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2052 (S)-苯并[d]㗁唑-2-基(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2053 (R)-苯并[d]㗁唑-2-基(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2054 (S)-苯并[d]㗁唑-2-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2055 (R)-苯并[d]㗁唑-2-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2056 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2057 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2058 (R)-2-環丙基-5-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2059 (S)-2-環丙基-5-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2060 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
2061 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
2062 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
2063 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
2064 (S)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2065 (R)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2066 (S)-(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2067 (R)-(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2068 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)甲酮
2069 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)甲酮
2070 (S)-(4-環丙基㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2071 (R)-(4-環丙基㗁唑-5-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2072 (R)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2073 (S)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2074 (S)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2075 (R)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2076 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(㗁唑-2-基)甲酮
2077 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(㗁唑-2-基)甲酮
2078 (S)-㗁唑-2-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2079 (R)-㗁唑-2-基(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2080 (S)-環丁基(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2081 (R)-環丁基(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2082 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-甲基-1,3,4-㗁二唑
2083 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-甲基-1,3,4-㗁二唑
2084 (R)-2-(二氟甲基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2085 (S)-2-(二氟甲基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2086 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
2087 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
2088 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
2089 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
2090 (R)-2-(2,6-二氟苯基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2091 (S)-2-(2,6-二氟苯基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2092 (R)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
2093 (S)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2,6-二氟苯基)-1,3,4-㗁二唑
2094 (R)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2095 (S)-4-(4-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2096 (R)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2097 (S)-4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2098 (S)-(2-環丙基㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2099 (R)-(2-環丙基㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2100 (S)-(2-(三級丁基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2101 (R)-(2-(三級丁基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2102 (S)-(2-環丙基㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2103 (R)-(2-環丙基㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2104 (S)-(2-(三級丁基)㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2105 (R)-(2-(三級丁基)㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2106 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(2-氟丙-2-基)㗁唑-5-基)甲酮
2107 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(2-氟丙-2-基)㗁唑-5-基)甲酮
2108 (R)-(2-(1-甲基-1H-吡唑-3-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2109 (S)-(2-(1-甲基-1H-吡唑-3-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2110 (S)-(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2111 (R)-(2-(1,5-二甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2112 (S)-(4-環丙基㗁唑-5-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2113 (R)-(4-環丙基㗁唑-5-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2114 (S)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2115 (R)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2116 (S)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2117 (R)-(4-環丙基-2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2118 (S)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2119 (R)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2120 (S)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2121 (R)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2122 (S)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2123 (R)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2124 (S)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2125 (R)-(4-環丙基-2-(吡啶-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2126 (R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2127 (S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-(吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2128 (R)-2-(4-氟苯基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2129 (S)-2-(4-氟苯基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2130 (R)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
2131 (S)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(4-氟苯基)-1,3,4-㗁二唑
2132 (R)-2-(2,6-二氟苯基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2133 (S)-2-(2,6-二氟苯基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2134 (R)-5-(6-氟吡啶-2-基)-4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2135 (S)-5-(6-氟吡啶-2-基)-4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2136 (S)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2137 (R)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2138 (S)-4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2139 (R)-4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2140 (S)-(2-環丙基㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2141 (R)-(2-環丙基㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2142 (S)-(2-(三級丁基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2143 (R)-(2-(三級丁基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2144 (S)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2145 (R)-(2-(2-氟丙-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2146 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2147 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2148 (S)-4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2149 (R)-4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2150 (R)-2-(二氟甲基)-5-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2151 (S)-2-(二氟甲基)-5-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2152 (R)-2-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(二氟甲基)-1,3,4-㗁二唑
2153 (S)-2-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(二氟甲基)-1,3,4-㗁二唑
2154 (R)-2-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2155 (S)-2-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2156 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2157 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2158 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2159 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2160 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2161 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2162 (S)-2-(嘧啶-4-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2163 (R)-2-(嘧啶-4-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2164 (S)-2-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2165 (R)-2-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2166 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(二氟甲基)-1,3,4-㗁二唑
2167 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(二氟甲基)-1,3,4-㗁二唑
2168 (R)-2-環丙基-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2169 (S)-2-環丙基-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2170 (S)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2171 (R)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2172 (S)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2173 (R)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2174 (S)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2175 (R)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2176 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2177 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2178 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嘧啶-4-基)-1,3,4-㗁二唑
2179 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嘧啶-4-基)-1,3,4-㗁二唑
2180 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嘧啶-4-基)-1,3,4-㗁二唑
2181 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嘧啶-4-基)-1,3,4-㗁二唑
2182 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嘧啶-4-基)-1,3,4-㗁二唑
2183 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嘧啶-4-基)-1,3,4-㗁二唑
2184 (R)-4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2185 (S)-4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2186 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-甲基-1,3,4-㗁二唑
2187 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-甲基-1,3,4-㗁二唑
2188 (R)-2-(1-甲基環丙基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2189 (S)-2-(1-甲基環丙基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2190 (R)-2-(1,1-二氟乙基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2191 (S)-2-(1,1-二氟乙基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2192 (R)-2-(1,1-二氟乙基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2193 (S)-2-(1,1-二氟乙基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2194 (R)-2-(1,1-二氟乙基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2195 (S)-2-(1,1-二氟乙基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2196 (R)-2-(1,1-二氟乙基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2197 (S)-2-(1,1-二氟乙基)-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2198 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嗒𠯤-3-基)-1,3,4-㗁二唑
2199 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嗒𠯤-3-基)-1,3,4-㗁二唑
2200 (S)-4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2201 (R)-4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2202 (R)-2-(1,1-二氟乙基)-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2203 (S)-2-(1,1-二氟乙基)-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2204 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1,1-二氟乙基)-1,3,4-㗁二唑
2205 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1,1-二氟乙基)-1,3,4-㗁二唑
2206 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基-吡啶-3-基)-1,3,4-㗁二唑
2207 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2208 (S)-2-(2-甲基吡啶-3-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2209 (R)-2-(2-甲基吡啶-3-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2210 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2211 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2212 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2213 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2214 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2215 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2216 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
2217 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
2218 (S)-(5-甲基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2219 (R)-(5-甲基-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2220 (R)-2-(二氟甲基)-5-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2221 (S)-2-(二氟甲基)-5-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2222 ((R)-2,2-二氟環丙基)((R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2223 ((R)-2,2-二氟環丙基)((S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2224 (R)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2225 (S)-4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2226 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2227 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2228 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2229 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2230 (R)-2-(1,1-二氟乙基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2231 (S)-2-(1,1-二氟乙基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2232 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1,1-二氟乙基)-1,3,4-㗁二唑
2233 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1,1-二氟乙基)-1,3,4-㗁二唑
2234 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2235 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2236 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2237 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2238 (R)-5-苯基-4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2239 (S)-5-苯基-4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2240 (S)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡𠯤-2-基)㗁唑-5-基)甲酮
2241 (R)-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡𠯤-2-基)㗁唑-5-基)甲酮
2242 (S)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡𠯤-2-基)㗁唑-5-基)甲酮
2243 (R)-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡𠯤-2-基)㗁唑-5-基)甲酮
2244 (S)-(2-(吡𠯤-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2245 (R)-(2-(吡𠯤-2-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2246 (R)-4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2247 (S)-4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2248 (R)-2-甲基-5-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2249 (S)-2-甲基-5-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2250 (R)-2-(二氟甲基)-5-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2251 (S)-2-(二氟甲基)-5-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2252 (R)-2-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2253 (S)-2-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2254 (S)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2255 (R)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2256 (S)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2257 (R)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2258 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2259 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2260 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡啶-3-基)-1,3,4-㗁二唑
2261 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡啶-3-基)-1,3,4-㗁二唑
2262 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡啶-3-基)-1,3,4-㗁二唑
2263 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡啶-3-基)-1,3,4-㗁二唑
2264 (S)-2-(2-氟吡啶-3-基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2265 (R)-2-(2-氟吡啶-3-基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2266 (R)-2-(3-甲基吡啶-2-基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2267 (S)-2-(3-甲基吡啶-2-基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2268 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2269 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基-吡啶-2-基)-1,3,4-㗁二唑
2270 (S)-5-(嘧啶-2-基)-4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2271 (R)-5-(嘧啶-2-基)-4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2272 (S)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2273 (R)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2274 (S)-2-(2-氟吡啶-3-基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2275 (R)-2-(2-氟吡啶-3-基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2276 (S)-2-(3-甲基吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2277 (R)-2-(3-甲基吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2278 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2279 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2280 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2281 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2282 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2283 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2284 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2285 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2286 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2287 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2288 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-氟吡啶-2-基)-1,3,4-㗁二唑
2289 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-氟吡啶-2-基)-1,3,4-㗁二唑
2290 (R)-(5-(5-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2291 (S)-(5-(5-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2292 (S)-(5-(4-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2293 (R)-(5-(4-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2294 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(5-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
2295 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(5-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
2296 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(4-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
2297 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(4-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)甲酮
2298 (R)-4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2299 (S)-4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2300 (R)-2-異丙基-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2301 (S)-2-異丙基-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2302 (R)-2-異丙基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2303 (S)-2-異丙基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2304 (R)-2-異丙基-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2305 (S)-2-異丙基-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2306 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2307 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2308 (R)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2309 (S)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2310 (R)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-苯基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2311 (S)-4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-5-苯基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2312 (R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-苯基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2313 (S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-苯基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2314 (S)-2-環丙基-5-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2315 (R)-2-環丙基-5-(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2316 (S)-4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2317 (R)-4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2318 (R)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2319 (S)-4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2320 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-異丙基-1,3,4-㗁二唑
2321 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-異丙基-1,3,4-㗁二唑
2322 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-異丙基-1,3,4-㗁二唑
2323 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-異丙基-1,3,4-㗁二唑
2324 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-異丙基-1,3,4-㗁二唑
2325 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-異丙基-1,3,4-㗁二唑
2326 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1,1-二氟乙基)-1,3,4-㗁二唑
2327 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1,1-二氟乙基)-1,3,4-㗁二唑
2328 (R)-2-(1,1-二氟乙基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2329 (S)-2-(1,1-二氟乙基)-5-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2330 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2331 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2332 (S)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基-吡啶-3-基)-1,3,4-㗁二唑
2333 (R)-2-(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-甲基吡啶-3-基)-1,3,4-㗁二唑
2334 (R)-2-(2-氟吡啶-3-基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2335 (S)-2-(2-氟吡啶-3-基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2336 (S)-2-(3-甲基吡啶-2-基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2337 (R)-2-(3-甲基吡啶-2-基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2338 (S)-2-(3-氟吡啶-2-基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2339 (R)-2-(3-氟吡啶-2-基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2340 (R)-2-(3-氟吡啶-2-基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2341 (S)-2-(3-氟吡啶-2-基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2342 (S)-2-(6-甲基吡啶-2-基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2343 (R)-2-(6-甲基吡啶-2-基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2344 (R)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑
2345 (S)-2-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(6-甲基-吡啶-2-基)-1,3,4-㗁二唑
2346 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑
2347 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑
2348 (S)-4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2349 (R)-4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-5-(5-(三氟甲基)吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2350 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-氟吡啶-3-基)-1,3,4-㗁二唑
2351 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(2-氟吡啶-3-基)-1,3,4-㗁二唑
2352 (S)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2353 (R)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(3-甲基吡啶-2-基)-1,3,4-㗁二唑
2354 (R)-2-(3-氟吡啶-2-基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2355 (S)-2-(3-氟吡啶-2-基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2356 (R)-2-(6-甲基吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2357 (S)-2-(6-甲基吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2358 (R)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑
2359 (S)-2-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(6-甲基吡啶-2-基)-1,3,4-㗁二唑
2360 (R)-2-(6-氟吡啶-2-基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2361 (S)-2-(6-氟吡啶-2-基)-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2362 (R)-2-(6-氟吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2363 (S)-2-(6-氟吡啶-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2364 (R)-(5-(5-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2365 (S)-(5-(5-氟吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2366 (S)-(5-(二氟甲基)-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2367 (R)-(5-(二氟甲基)-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2368 (S)-(5-(二氟甲基)-1-(2,2,2-三氟乙基)-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2369 (R)-(5-(二氟甲基)-1-(2,2,2-三氟乙基)-1H-吡唑-4-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2370 (S)-(3-胺基-1-(二氟甲基)-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2371 (R)-(3-胺基-1-(二氟甲基)-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2372 (S)-(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2373 (R)-(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2374 (4-氯-2-(1-羥基乙基)㗁唑-5-基)((R)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#2 (Rt=7.091 min)
2375 (4-氯-2-(1-羥基乙基)㗁唑-5-基)((R)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#1 (Rt=6.819 min)
2376 (4-氯-2-(1-羥基乙基)㗁唑-5-基)((S)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#1 (Rt=5.341 min)
2377 (4-氯-2-(1-羥基乙基)㗁唑-5-基)((S)-4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮 非鏡像異構物#2 (Rt=6.340 min)
2378 (S)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-羥基丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
2379 (R)-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(2-羥基丙-2-基)-1,3,4-㗁二唑-2-基)甲酮
2380 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2381 (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2382 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
2383 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(2-(2-羥基丙-2-基)㗁唑-5-基)甲酮
2384 (S)-(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
2385 (R)-(4-(5-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)甲酮
2386 (S)-(1-環丙基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2387 (R)-(1-環丙基-1H-吡唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2388 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(吡啶-2-基)-1H-吡唑-5-基)甲酮
2389 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-(吡啶-2-基)-1H-吡唑-5-基)甲酮
2390 (S)-(1,3-二甲基-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2391 (R)-(1,3-二甲基-1H-吡唑-5-基)(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2392 (R)-(1,3-二甲基-1H-1,2,4-三唑-5-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2393 (S)-(1,3-二甲基-1H-1,2,4-三唑-5-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2394 (R)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2395 (S)-(5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2396 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)甲酮
2397 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)甲酮
2398 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)甲酮
2399 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)甲酮
2400 (S)-(4-(二氟甲基)㗁唑-5-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2401 (R)-(4-(二氟甲基)㗁唑-5-基)(4-(5-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2402 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2403 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(6-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2404 (S)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2405 (R)-(5-環丙基-1,3,4-㗁二唑-2-基)(4-(6-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2406 (S)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2407 (R)-(4-(二氟甲基)-2-(2-羥基丙-2-基)㗁唑-5-基)(4-(5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2408 (R)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2409 (S)-(5-(三級丁基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2410 (S)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2411 (R)-(3-(二氟甲基)-1-甲基-1H-1,2,4-三唑-5-基)(4-(5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2412 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)甲酮
2413 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(1-甲基-3-(三氟甲基)-1H-1,2,4-三唑-5-基)甲酮
2414 (S)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2415 (R)-(5-(吡啶-2-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2416 (S)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2417    (R)-(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2418 (R)-(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2419 (S)-(3-環丙基-1-甲基-1H-1,2,4-三唑-5-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2420 (S)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2421 (R)-(5-(2-氟丙-2-基)-1,3,4-㗁二唑-2-基)(4-(6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2422 (2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)((S)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2423 (2-((S)-1-羥基乙基)-4-甲基㗁唑-5-基)((R)-4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2424 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
2425 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(吡唑并[1,5-a]吡啶-3-基)甲酮
2426 (S)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2427 (R)-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2428 (S)-(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2429 (R)-(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2430 (S)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2431 (R)-(5-環丁基-1,3,4-㗁二唑-2-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2432 (R)-2-環丙基-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2433 (S)-2-環丙基-5-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2434 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)甲酮
2435 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)甲酮
2436 (S)-(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2437 (R)-(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2438 (S)-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2439 (R)-(6-(1-甲基-1H-吡唑-4-基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2440 (S)-2-(吡啶-2-基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2441 (R)-2-(吡啶-2-基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2442 (R)-2-甲基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2443 (S)-2-甲基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2444 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2445 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2446 (S)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2447 (R)-(5-(1-(二氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2448 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
2449 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(吡𠯤-2-基)-1,3,4-㗁二唑-2-基)甲酮
2450 (S)-(6-甲氧基吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2451 (R)-(6-甲氧基吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2452 (S)-(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2453 (R)-(6-(吡啶-2-基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2454 (S)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2455 (R)-4-(7-氯吡唑并[1,5-a]吡啶-2-基)-5-(嘧啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
2456 (S)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-甲基-1,3,4-㗁二唑
2457 (R)-2-(4-(4-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-甲基-1,3,4-㗁二唑
2458 (S)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2459 (R)-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(5-(1-(三氟甲基)-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2460 (R)-2-(二氟甲基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2461 (S)-2-(二氟甲基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2462 (S)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2463 (R)-(6-環丙基吡唑并[1,5-a]吡啶-3-基)(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2464 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
2465 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲氧基吡唑并[1,5-a]吡啶-3-基)甲酮
2466 (R)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-甲基-1,3,4-㗁二唑
2467 (S)-2-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-甲基-1,3,4-㗁二唑
2468 (R)-(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2469 (S)-(5-(嘧啶-2-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2470 (S)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
2471 (R)-(4-(4-甲氧基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-甲基吡唑并[1,5-a]吡啶-3-基)甲酮
2472 (S)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2473 (R)-(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2474 (S)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)甲酮
2475 (R)-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(二甲胺基)吡唑并[1,5-a]吡啶-3-基)甲酮
2476 (S)-(6-(2-(二甲胺基)乙基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2477 (R)-(6-(2-(二甲胺基)乙基)吡唑并[1,5-a]吡啶-3-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2478 (S)-(6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2479 (R)-(6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
2480 (R)-2-環丁基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2481 (S)-2-環丁基-5-(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2482 (S)-2-環丁基-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2483 (R)-2-環丁基-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2484 (R)-2-環丁基-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2485 (S)-2-環丁基-5-(4-(4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
2486 (R)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
2487 (S)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-5-(三氟甲基)-1,3,4-㗁二唑
2488 (S)-(4-(6-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2489 (R)-(4-(6-溴吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑-2-基)甲酮
2490 (R)-2-(三氟甲基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2491 (S)-2-(三氟甲基)-5-(4-(7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2492 (R)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2493 (S)-2-(4-(7-氯吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(三氟甲基)-1,3,4-㗁二唑
2494 (S)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
2495 (R)-(4-(4-環丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(5-甲基-1,3,4-㗁二唑-2-基)甲酮
2496 (S)-(2-環丙基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2497 (R)-(2-環丙基㗁唑-5-基)(4-(吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2498 (R)-(2-(1-甲基-1H-吡唑-3-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2499 (S)-(2-(1-甲基-1H-吡唑-3-基)㗁唑-5-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2500 (R)-(5-甲基-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2501 (S)-(5-甲基-1,3,4-噻二唑-2-基)(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2502 (S)-苯并[d]噻唑-2-基(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2503 (R)-苯并[d]噻唑-2-基(4-(4-甲基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2504 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(1-甲基-1H-吡唑-3-基)㗁唑-5-基)甲酮
2505 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(1-甲基-1H-吡唑-3-基)㗁唑-5-基)甲酮
2506 (S)-(2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2507 (R)-(2-(1-甲基-1H-吡唑-4-基)㗁唑-5-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)甲酮
2508 (R)-2-環丙基-5-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2509 (S)-2-環丙基-5-(4-(4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2510 (S)-2-(吡𠯤-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2511 (R)-2-(吡𠯤-2-基)-5-(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2512 (S)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嗒𠯤-3-基)-1,3,4-㗁二唑
2513 (R)-2-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(嗒𠯤-3-基)-1,3,4-㗁二唑
2514 (R)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2515 (S)-2-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(1-甲基環丙基)-1,3,4-㗁二唑
2516 (S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡𠯤-2-基)㗁唑-5-基)甲酮
2517 (R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)(2-(吡𠯤-2-基)㗁唑-5-基)甲酮
2518 (R)-2-(3,3-二氟環丁基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2519 (S)-2-(3,3-二氟環丁基)-5-(4-(4-異丙基吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2520 (R)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2521 (S)-2-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-5-(吡𠯤-2-基)-1,3,4-㗁二唑
2522 (R)-2-(1,1-二氟乙基)-5-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2523 (S)-2-(1,1-二氟乙基)-5-(4-(7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫-5H-咪唑并[4,5-c]吡啶-5-基)-1,3,4-㗁二唑
2524 (5-(2,6-二氟苯基)-1,3,4-㗁二唑-2-基)(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
在進一步實施例中，式I之化合物係表1中之化合物（其係S-鏡像異構物）中之一或多者或其醫藥上可接受之鹽。
在仍進一步實施例中，式I之化合物係實例605、626、640、670、688、708、710、726、728、733、748、760、762、764、791、836、840、906、922、938、942、944、946、948、950、952、954、957、958、960、962、964、966、969、971、972、975、976、979、980、982、984、988、1381、1438、1461、1506、1531、1548、1589、1607、1613、1628、1652、1657、1728、1737、1757、1807、1809、1823、1843、1849、1850、1943、1953、1986、2218、2221、及2223中之一或多者、或其醫藥上可接受之鹽。在又其他實施例中，式I之化合物係實例640、670、688、708、710、726、728、733、748、760、762、764、836、840、906、922、938、942、944、946、948、950、952、954、957、960、962、969、971、972、975、976、979、980、984、988、1438、1461、1506、1548、1628、1652、1657、1728、1737、1757、1809、1849、1850、1953、1986、2218、及2221中之一或多者、或其醫藥上可接受之鹽。在仍其他實施例中，式I之化合物係實例640、670、688、708、710、726、728、733、748、760、762、764、836、840、906、922、938、942、944、946、948、950、952、954、957、960、962、969、971、972、975、976、979、980、984、988、1438、1461、1506、1548、1628、1652、1657、1728、1986、及2218中之一或多者、或其醫藥上可接受之鹽。
縮寫及用語列表：
aq 水性
min 分鐘
hrs 小時
mL 毫升
µL 微升
mmol 毫莫耳
µmol 微莫耳
mol 莫耳
M 莫耳濃度
eq 當量
LCMS 液相層析-質譜法
NMR 核磁共振
TLC 薄層層析
HPLC 高效液相層析
SFC 超臨界流體層析
sat 飽和
℃ 攝氏度
rt 室溫
N 2 氮氣
Hz 赫茲
δ 化學位移
s 單峰
d 雙重峰
t 三重峰
q 四重峰
m 多重峰
br 寬
dd 雙重雙重峰
ddd 雙重雙重峰或雙重峰
td 三重雙重峰
dt 雙重三重峰
CDCl 3 氯仿- d
CD 3OD 甲醇 -d 4
DMSO-d 6 二甲基亞碸- d 6
溶劑及試劑：
DCE 1,2-二氯乙烷
DCM 二氯甲烷
DMAc 二甲基乙醯胺
DME 二甲氧基乙烷
DMF 二甲基甲醯胺
EtOH 乙醇
EtOAc 乙酸乙酯
i-PrOH或IPA 異丙醇
MeOH 甲醇
TAA 三級戊醇
MeCN或ACN 乙腈
PE 石油醚
TBME 三級丁基甲醚
H 2O 水
THF 四氫呋喃
HOAc 乙酸
HCl 鹽酸
H 2SO 4 硫酸
FA 甲酸
TFA 三氟乙酸
TsOH 對甲苯磺酸
TosCl或TsCl 對甲苯磺醯氯
NH 4C1 氯化銨
KOH 氫氧化鉀
LiOH 氫氧化鋰
K 2CO 3 碳酸鉀
Na 2CO 3 碳酸鈉
Cs 2CO 3 碳酸銫
Na 2SO 4 硫酸鈉
NaHCO 3 碳酸氫鈉
Na 2S 2O 3 硫代硫酸鈉
Et 3N或TEA 三乙胺
DIPEA N,N-二異丙基乙胺
Py 吡啶
KOAc 乙酸鉀
KF 氟化鉀
CsF 氟化銫
NH 3 氨
LDA 二異丙胺鋰
LiHMDS 雙(三甲基矽基)醯胺鋰
MeMgBr 甲基溴化鎂
iPrMgCl.LiCl 異丙基氯化鎂氯化鋰複合物
PFIB 全氟異丁烯
BuOK 三級丁醇鉀
CAN 硝酸鈰銨
DIBAL-H 二異丁基氫化鋁
NaOMe 甲醇鈉
DMP Dess-Martin高碘烷
MnO 2 氧化錳(IV)
IBX 2-碘氧基苯甲酸
t-BuONO 亞硝酸三級丁酯
PIDA (二乙醯氧基碘)苯
NFSI N-氟二(苯磺醯基)胺
NBS N-溴琥珀醯亞胺
NCS N-氯琥珀醯亞胺
MeI 碘甲烷
LiBH 4 硼氫化鋰
NaBH 4 硼氫化鈉
NaBH(OAc) 3 三乙醯氧基硼氫化鈉
EDCI 1-乙基-3-(3-二甲胺基丙基)碳二亞胺
HOBt 1-羥基苯并三唑
HATU 1-[雙(二甲胺基)亞甲基]-1H-1,2,3-三唑并[4,5-b]吡啶鎓3-氧化物六氟磷酸鹽
T3P 丙烷膦酸酐
CDI 羰基二咪唑
硫代-CDI 1,1'-硫代羰基二咪唑
DPPA 二苯基磷醯基疊氮
BCl 3 三氯化硼
Boc 2O 二-三級丁基二碳酸酯
DHP 二氫哌喃
Pd/C 鈀碳
Pd(PPh 3) 2Cl 2 雙(三苯基膦)二氯化鈀(II)
Pd 2(dba) 3 參(二亞苄丙酮)二鈀
Pd(dppf)Cl 2 (1,1'-雙(二苯基膦基)二茂鐵)二氯化鈀(II)
Pd(OAc) 2 乙酸鈀(II)
Xantphos 4,5-雙(二苯基膦基)-9,9-二甲基氧雜蒽
t-BuXPhos-Pd-G3 [(2-二-三級丁基膦基-2',4',6'-三異丙基-1,1'-聯苯基)-2-(2'-胺基-1,1'-聯苯基)]甲磺酸鈀(II)
CPhos-Pd-G3 [(2-二環己基膦-2',6'-雙(N,N-二甲胺基)-1,1'-聯苯基)-2-(2'-胺基-1,1'-聯苯基)]甲磺酸鈀(II)
PPh 3 三苯膦
DEAD 偶氮二碳酸二乙酯
Pin 2B 2 雙(頻哪醇基)二硼烷
CuI 碘化銅
CuBr 2 溴化銅(II)
Zn(CN) 2 氰化鋅
H 2 氫氣
SiO 2 二氧化矽
TFAA 三氟乙酸酐
K 2OsO 4.2H 2O 鋨酸鉀(VI)二水合物
NaIO 4 高碘酸鈉
一般實驗
在以下實例中，試劑及溶劑係購自商業來源（諸如Alfa、Acros、AstaTech、CombiBlocks、Enamine、Sigma Aldrich、TCI、PharmaBock、Bide Pharmatech Ltd.、Accela ChemBio、Aladdin、Shanghai Haohong Pharmaceutical Co., Ltd、Amkchem、Beijing Ouhe Technology Co., Ltd、Haoyuan Chemexpress Co., Ltd、Hualun、Coolpharm、Scochem、Titan、及WuXi LabNetwork），且除非另外指明，否則不經進一步純化即被使用。在CombiFlashRf 150 (ISCO)上經由具有200至300目矽膠顆粒之管柱進行快速層析。在Agilent 1100液相層析(Agilent, USA)及Shimadzu LC 20/20A (Shimadzu, Japan)上進行HPLC。在Waters Prep SFC 150 AP /80Q /200 / 350系統(Waters, USA)上進行超臨界流體層析。分析及製備型薄層層析板(thin layer chromatography plate, TLC)係HSGF 254（厚度為0.15-0.2 mm，Shanghai Anbang Company, China）。在Brucker AV-400 NMR或Bruker AVIII 500 MHz NMR (Bruker, Switzerland)上獲得核磁共振(Nuclear magnetic resonance, NMR)光譜。化學位移係以自四甲基矽烷之百萬分之一(parts per million, ppm, δ)低場記述。質譜用來自Waters LCT TOF質譜儀(Waters, USA)之電噴霧電離(electrospray ionization, ESI)給出。在Agilent Prime-6125B/ Agilent LC1260-MS6150/ Agilent LC1260-MS6125B/ Agilent LC1200-MS6110 (Agilent, USA)及Shimadzu LC20-MS2020上進行LC-MS。在Initiator 2.5微波合成器(Biotage, Sweden)上進行微波反應。 中間物(1-(1H-咪唑-5-基)環丙基)甲胺鹽酸鹽 步驟1：製備2-(3-三苯甲基咪唑-4-基)乙腈(B2)
以2-(1H-咪唑-5-基)乙腈(B1)開始根據文獻程序來製備B2。參見例如WO2008/003766（第19頁）。 步驟2：製備1-(3-三苯甲基咪唑-4-基)環丙烷甲腈(B3)
在-78℃下，向2-(3-三苯甲基咪唑-4-基)乙腈(B2) (10 g, 28.6 mmol)在THF (200 mL)中之溶液中，逐滴添加LDA (2 M, 42.9 mL, 3 eq)。添加完成後，將反應混合物在-20℃至-10℃下攪拌1小時。隨後將反應混合物冷卻至-78℃，且在-78℃下逐滴添加1,2-二溴乙烷(10.75 g, 57.2 mmol, 4.32 mL, 2 eq)。添加完成後，將反應混合物緩慢溫熱至室溫，且再攪拌2小時。使用TLC (PE:EtOAc=1:1)來追蹤反應進程。將反應混合物用飽和NH 4Cl溶液(200 mL)淬滅且在室溫下攪拌0.5小時。將水性部分用EtOAc (100 mL × 3)萃取，且合併之有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物（與使用10 g B2進行之兩個其他反應合併）藉由快速矽膠層析（ISCO ®；120 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至40% EtOAc/PE，梯度在40 mL/min下）純化，以得到B3（23.4 g，72%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ 7.30-7.52 (m, 10 H), 7.09 (dd, 6 H), 6.84 (d, 1 H), 1.51-1.66 (m, 2 H), 1.29-1.46 (m, 2 H)。 步驟3：製備1-(3-三苯甲基咪唑-4-基)環丙基]甲胺(B4)
將1-(3-三苯甲基咪唑-4-基)環丙烷甲腈(B3) (19 g, 50.6 mmol)、雷氏Ni (Raney-Ni) (4.60 g, 53.7 mmol, 1.06 eq)、NH 3.H 2O（591 mg，5.06 mmol，650 µL，30%純度，0.1 eq）於MeOH (200 mL)中之混合物除氣且用H 2吹掃3次，然後將反應混合物在45℃下在H 2(45 psi)氣氛下攪拌16小時。使用TLC (DCM:MeOH=10:1)追蹤反應進程。將反應混合物過濾，並添加額外的雷氏Ni (4.60 g, 53.7 mmol, 1.06 eq)。將反應混合物在45℃下在H 2(45 psi)氣氛下再攪拌24小時。將反應混合物經由矽藻土墊過濾，且將濾液濃縮至乾燥，以得到B4 (18 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6 ) δ 7.33-7.44 (m, 9 H), 7.18-7.25 (m, 1 H), 7.04-7.13 (m, 6 H), 6.64-6.71 (m, 1 H), 3.17 (br s, 2 H), 2.58-2.74 (m, 2 H), 0.60-0.82 (m, 4 H)。 步驟4：製備[1-(1H-咪唑-5-基)環丙基]甲胺鹽酸鹽(B5)
向[1-(3-三苯甲基咪唑-4-基)環丙基]甲胺(B4) (18 g, 47.4 mmol)在MeOH (100 mL)中之溶液中添加HCl/MeOH (4 M, 100 mL, 8.4 eq)。將反應混合物在60℃下攪拌16小時。使用LC-MS追蹤反應進程。將反應混合物濃縮至乾燥，且將殘餘物用EtOAc (40 mL)磨碎並攪拌15分鐘。將沉澱物藉由過濾收集且隨後真空乾燥，以得到B5（8.5 g，2HCl鹽）。 1H NMR (400 MHz, DMSO- d 6 ) δ 14.73 (br s, 1 H), 9.04 (s, 1 H), 8.27 (br s, 2 H), 7.51 (s, 1 H), 2.98-3.22 (m, 2 H), 0.90-1.23 (m, 4 H)。 中間物2-(1H-咪唑-5-基)-2-甲基丙-1-胺鹽酸鹽 步驟1：製備(2-甲基-2-(3-三苯甲基咪唑-4-基)丙腈(B6)
在-78℃下向2-(3-三苯甲基咪唑-4-基)乙腈(B2) (12 g, 34.3 mmol)在THF (400 mL)中之溶液中，逐滴添加LiHMDS (1 M, 96.2 mL, 2.8 eq)。將反應混合物在-78℃下攪拌15分鐘，且隨後添加MeI (14.62 g, 103 mmol, 6.41 mL, 3 eq)。將反應混合物在-78℃下攪拌1小時，且隨後溫熱至室溫持續18小時。使用TLC (PE:EtOAc =1:1)追蹤反應進程。將反應混合物冷卻至0℃，藉由添加飽和NH 4Cl溶液(15 mL)淬滅，且然後添加H 2O (60 mL)。將水性部分用EtOAc (60 mL × 3)萃取。將合併之有機層用鹽水(60 mL)洗滌，經Na 2SO 4乾燥，且濃縮至乾燥。將殘餘物（與來自使用2 g B2進行之另一反應之殘餘物合併）藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至80% EtOAc/PE，梯度在60 mL/min下）純化，以得到B6（14 g，92%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.41 (d, 1 H), 7.32-7.39 (m, 9 H), 7.08-7.16 (m, 6 H), 6.81 (d, 1 H), 1.69 (s, 6 H)。 步驟2：製備(2-甲基-2-(3-三苯甲基咪唑-4-基)丙-1-胺(B7)
在N 2下向2-甲基-2-(3-三苯甲基咪唑-4-基)丙腈(B6) (14 g, 37.1 mmol)在MeOH (350 mL)中之溶液中，添加雷氏Ni (2 g, 23.3 mmol, 0.63 eq)。將反應混合物真空除氣且用H 2吹掃若干次。將反應混合物在H 2(50 psi)下在40℃下攪拌36小時。使用TLC (PE:EtOAc =1:1)追蹤反應進程。將反應混合物經由矽藻土墊過濾，且將濾液濃縮至乾燥，以得到B7（12 g，85%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.38 (s, 1 H), 7.29-7.36 (m, 9 H), 7.10-7.18 (m, 6 H), 6.55 (s, 1 H), 3.49 (br s, 1 H), 2.74 (s, 2 H), 1.20 (s, 6 H)；LCMS: m/z 382.2 [M+H] +。 步驟3：製備(2-(1H-咪唑-5-基)-2-甲基-丙-1-胺(B8)
向2-甲基-2-(3-三苯甲基咪唑-4-基)丙-1-胺(B7) (14 g, 36.7 mmol)在MeOH (150 mL)中的溶液中添加HCl/MeOH (4 M, 150 mL, 16.4 eq)，並將反應混合物在50℃下攪拌18小時。使用TLC (EtOAc)跟蹤反應進程。將反應混合物濃縮至乾燥，且添加200 mL EtOAc。將混合物在60℃下攪拌1小時。將沉澱物藉由過濾收集且用EtOAc沖洗，且隨後真空乾燥，以得到B8（7.0 g，90%產率，2HCl鹽）。 1H NMR (400 MHz, CD 3OD) δ 8.96 (s, 1 H), 7.52 (s, 1 H), 3.20-3.27 (m, 2 H), 1.49 (s, 6 H)。 中間物2-(1H-咪唑-5-基)丙-1-胺鹽酸鹽 步驟1：製備2-(3-三苯甲基咪唑-4-基)丙腈(B9)
在-78℃下，向2-(3-三苯甲基咪唑-4-基)乙腈(B2) (15 g, 42.9 mmol)在THF (120 mL)中之溶液中，逐滴添加LiHMDS (1 M, 51.5 mL, 1.2 eq)。添加後，將反應混合物攪拌0.5小時，且然後在-78℃下逐滴添加MeI (10.97 g, 77.3 mmol, 4.81 mL, 1.8 eq)。將反應混合物在-78℃下攪拌2小時。使用TLC (PE:EtOAc=2:1)追蹤反應進程。將反應混合物藉由添加飽和NH 4Cl溶液(120 mL)淬滅並攪拌15分鐘。將水性部分用EtOAc (400 mL)萃取，且將有機層藉由水(100 mL)及鹽水(60 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物（與來自使用15 g B2進行之另一反應的殘餘物合併）藉由矽膠管柱層析（PE:EtOAc=20:1至2:1）純化，以得到B9（33.5 g，75%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 7.38-7.45 (m, 10 H), 7.06-7.13 (m, 6 H), 6.82-6.92 (m, 1 H), 4.12-4.23 (m, 1 H), 1.48 (d, 3 H)。 步驟2：製備2-(3-三苯甲基咪唑-4-基)丙-1-胺(B10)
將2-(3-三苯甲基咪唑-4-基)丙腈(B9) (16.5 g, 45.4 mmol)、雷氏Ni (4.08 g, 47.7 mmol, 1.05 eq)、NH 3.H 2O（910 mg，7.79 mmol，1 mL，30%純度）在MeOH (300 mL)中之混合物真空除氣且用H 2吹掃3次。將反應混合物在45℃下在H 2(45 psi)氣氛下攪拌16小時。使用TLC (PE:EtOAc=2:1)追蹤反應進程。將反應混合物經由矽藻土墊過濾，且將濾液濃縮至乾燥，以得到B10 (33 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, CD 3OD) δ 7.36-7.44 (m, 10 H), 7.13-7.20 (m, 6 H), 6.72 (br s, 1 H), 2.57-2.92 (m, 3 H), 1.21 (br d, 3 H)。 步驟3：製備2-(1H-咪唑-5-基)丙-1-胺(B11)
向2-(3-三苯甲基咪唑-4-基)丙-1-胺(B10) (23 g, 62.6 mmol)在MeOH (100 mL)中之溶液中，添加HCl/MeOH (4 M, 100 mL)。將混合物在室溫下攪拌12小時。使用TLC (EtOAc)追蹤反應進程。將反應混合物（與來自使用23 g B10進行之另一反應的反應混合物合併）濃縮至乾燥。將H 2O (40 mL)添加至殘餘物中，且將水層用EtOAc (50 mL)洗滌。將水層凍乾，以得到B11 (21 g, 2HCl)。 1H NMR (400 MHz, CD 3OD) δ 8.96 (d, 1 H), 7.56 (s, 1 H), 3.43-3.51 (m, 1 H), 3.17-3.32 (m, 2 H), 1.29-1.53 (m, 3 H)。 中間物2-[(2R)-2-(1H-咪唑-5-基)丙基]異吲哚啉-1,3-二酮及2-[(2S)-2-(1H-咪唑-5-基)丙基]異吲哚啉-1,3-二酮 步驟1：製備2-[2-(1H-咪唑-5-基)丙基]異吲哚啉-1,3-二酮(B13)
向2-(1H-咪唑-5-基)丙-1-胺(B11) (10 g, 50.5 mmol, 2HCl)及鄰苯二甲酸酐(7.85 g, 53.0 mmol, 1.05 eq)在i-PrOH (400 mL)中之溶液中，添加Et 3N (15.32 g, 151 mmol, 21.1 mL, 3 eq)。在N 2氣氛下在100℃下將反應混合物攪拌18小時。冷卻後，將反應混合物濃縮至乾燥。然後添加水(200 mL)，且將混合物在室溫下攪拌10分鐘。將沉澱物藉由過濾收集，用水(100 mL)沖洗，且真空乾燥，以得到B13 (13 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 7.71-7.89 (m, 4 H), 7.49 (s, 1 H), 6.79 (s, 1 H), 3.70-3.76 (m, 1 H), 3.60-3.65 (m, 1 H), 3.15-3.23 (m, 1 H), 1.16 (d, 3 H)。 步驟2：SFC分離
將化合物2-[2-(1H-咪唑-5-基)丙基]異吲哚啉-1,3-二酮(13 g)藉由SFC分離（管柱：DAICEL CHIRALPAK AD(250 mm*50 mm, 10um)；移動相：[0.1%NH 3H 2O ETOH]；B%：40%至40%，min）分離，以得到鏡像異構物1（4.8 g，37%產率，Rt=3.953 min）及鏡像異構物2（5.2 g，40%產率，Rt=4.652 min）。
鏡像異構物1：2-[(2R)-2-(1H-咪唑-5-基)丙基]異吲哚啉-1,3-二酮(B13A)。 1H NMR (400 MHz, CD 3OD) δ 7.73-7.89 (m, 4 H), 7.56 (d, 1 H), 6.82 (s, 1 H), 3.84-3.93 (m, 1 H), 3.70-3.82 (m, 1 H), 3.36-3.39 (m, 1 H), 1.31 (d, 3 H)；SFC: 98.4% ee。
鏡像異構物2：2-[(2S)-2-(1H-咪唑-5-基)丙基]異吲哚啉-1,3-二酮(B13B)。 1H NMR (400 MHz, CD 3OD) δ 7.77-7.88 (m, 4 H), 7.55 (d, 1 H), 6.82 (s, 1 H), 3.84-3.97 (m, 1 H), 3.72-3.82 (m, 1 H), 3.36-3.42 (m, 1 H), 1.31 (d, 3 H)；SFC: 99.1% ee。 中間物吡唑并[1,5-a]吡啶-2-甲醛 步驟1：製備N-甲氧基-N-甲基-吡唑并[1,5-a]吡啶-2-羧醯胺(C2)
向吡唑并[1,5-a]吡啶-2-羧酸(C1) (12.5 g, 77.1 mmol)及N-甲氧基甲胺(9.42 g, 96.6 mmol, 1.25 eq, HCl)在DMF (200 mL)中之溶液中，添加EDCI (22.17 g, 116 mmol, 1.5 eq)、DIPEA (29.89 g, 231 mmol, 40.3 mL, 3 eq)及HOBt (15.63 g, 116 mmol, 1.5 eq)。將反應混合物在室溫下攪拌12小時。使用TLC (PE:EtOAc=1:1)檢查反應進程。將反應混合物與來自使用12.5 g C1進行之另一反應的反應混合物合併，並濃縮至乾燥。將殘餘物溶解在DCM (200 mL)中，且將有機層用飽和Na 2CO 3溶液(100 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由矽膠管柱層析（PE:EtOAc=20:1至1:1）純化，以得到C2（30.5 g，96%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.47-8.54 (m, 1 H), 7.59 (d, 1 H), 7.16 (ddd, 1 H), 7.02 (s, 1 H), 6.86 (td, 1 H), 3.81 (s, 3 H), 3.51 (s, 3 H)。 步驟2：製備吡唑并[1,5-a]吡啶-2-甲醛(C3)
在-78℃下在N 2下，向N-甲氧基-N-甲基-吡唑并[1,5-a]吡啶-2-羧醯胺(C2) (15 g, 73.1 mmol)在THF (150 mL)中之溶液中逐滴添加DIBAL-H (1 M, 146.2 mL, 2 eq)，且然後將反應混合物在-78℃下在N 2下攪拌2小時。使用TLC (PE:EtOAc=1:1)追蹤反應進程。將反應混合物與來自使用15 g C2進行之另一反應之反應混合物合併，且藉由添加飽和NH 4Cl溶液(200 mL)緩慢淬滅並攪拌15分鐘。添加1 M HCl溶液直至觀察到澄清溶液。將水性部分用EtOAc (250 mL × 3)萃取，且將合併之有機層用水(100 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由矽膠管柱層析（PE:EtOAc=20:1至1:1）純化，以得到C3 (14.2 g)。 1H NMR (400 MHz, DMSO- d 6 ) δ 10.14 (s, 1 H), 8.81 (dd, 1 H), 7.84 (d, 1 H), 7.34 (t, 1 H), 7.10-7.15 (m, 2 H)。
按照上文針對C3所述之一般程序，以3-甲基吡唑并[1,5-a]吡啶-2-羧酸開始來製備中間物3-甲基吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C3所述之一般程序，以3-溴吡唑并[1,5-a]吡啶-2-羧酸開始來製備中間物3-溴吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C3所述之一般程序，以4-氯吡唑并[1,5-a]吡啶-2-羧酸開始來製備中間物4-氯吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C3所述之一般程序，以6-溴吡唑并[1,5-a]吡啶-2-羧酸開始來製備中間物6-溴吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C3所述之一般程序，以6-氯吡唑并[1,5-a]吡啶-2-羧酸開始來製備中間物6-氯吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C3所述之一般程序，以7-甲基吡唑并[1,5-a]吡啶-2-羧酸開始來製備中間物7-甲基吡唑并[1,5-a]吡啶-2-甲醛。 中間物4-氟吡唑并[1,5-a]吡啶-2-甲醛 步驟1：製備3-(3-氟-2-吡啶基)丙-2-炔-1基乙酸酯(C5)
將2-溴-3-氟-吡啶(C4) (30 g, 170 mmol)、丙-2-炔-1基乙酸酯(23.41 g, 239 mmol, 1.4 eq)、Pd(PPh 3) 2Cl 2(5.98 g, 8.52 mmol, 0.05 eq)、CuI (1.62 g, 8.52 mmol, 0.05 eq)及TEA (51.75 g, 511 mmol, 71.2 mL, 3 eq)在二㗁烷(300 mL)中之混合物除氣，並用N 2吹掃3次，然後將反應混合物在50℃下在N 2氣氛下攪拌6小時。使用TLC (PE:EtOAc=5:1)檢查反應進程。將反應混合物濃縮至乾燥。將EtOAc (600 mL)添加至殘餘物中，且將有機部分用水(300 mL)及鹽水(300 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；120 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至20% EtOAc/PE，梯度在120 mL/min下）純化，以得到C5（23.4 g，71%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.43 (d, 1 H), 7.46 (td, 1 H), 7.32 (dt, 1 H), 4.99 (s, 2 H), 2.16 (s, 3 H)。 步驟2：製備3-(3-氟-2-吡啶基)丙-2-炔-1-醇(C6)
在0℃下，向3-(3-氟-2-吡啶基)丙-2-炔基乙酸酯(C5) (23.4 g, 121 mmol)在THF (300 mL)及H 2O (150 mL)中之溶液中，添加LiOH.H 2O (5.34 g, 127 mmol, 1.05 eq)。將反應混合物在室溫下攪拌2小時。使用TLC (PE:EtOAc=1:1)檢查反應進程。將EtOAc (600 mL)添加至反應混合物中，且將有機層用H 2O (400 mL)及鹽水(400 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到C6 (17.5 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.34-8.53 (m, 1 H), 7.72-7.88 (m, 1 H), 7.50 (dt, 1 H), 5.54 (t, 1 H), 4.38 (d, 2 H)。 步驟3：製備1-胺基-3-氟-2-(3-羥基丙-1-炔-1-基)吡啶-1-鎓2,4,6-三甲基苯磺酸酯(C7)
在0℃下，向H 2O (35 mL, 1.94 mol, 17.3 eq)及TFA (308.0 g, 2.70 mol, 200 mL, 24.0 eq)之混合物中，添加(1E)-N-(2,4,6-三甲基苯基)磺醯氧基乙亞胺酸乙基酯(33.70 g, 118 mmol, 1.05 eq)，且將反應混合物在0℃下攪拌2小時。將反應用冰水(40 mL)淬滅。將沉澱物過濾，且用水(20 mL×2)洗滌。接著將沉澱物溶解於DCM (200 mL)中且經Na 2SO 4乾燥並過濾。在0℃下向濾液中添加3-(3-氟-2-吡啶基)丙-2-炔-1-醇(C6) (17 g, 112 mmol, 1 eq)。將反應混合物溫熱至室溫持續16小時。使用TLC (PE:EtOAc=1:1)檢查反應進程。將TBME (400 mL)緩慢添加至反應混合物中，且將沉澱物藉由過濾收集。將沉澱物用TBME (200 mL×2)沖洗，以得到C7 (26 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.66-8.88 (m, 3 H), 8.32 (t, 1 H), 8.01 (dt, 1 H), 6.75 (s, 2 H), 4.58 (s, 2 H), 3.17 (s, 1 H), 2.49 (s, 6 H), 2.17 (s, 3 H)。 步驟4：製備(4-氟吡唑并[1,5-a]吡啶-2-基)甲醇(C8)
在0℃下向1-胺基-3-氟-2-(3-羥基丙-1-炔-1-基)吡啶-1-鎓2,4,6-三甲基苯磺酸酯(C7) (26 g, 71.0 mmol)在MeOH (250 mL)中之溶液中，添加NaOMe (5.4 M, 26.3 mL, 2 eq)。在室溫下將反應混合物攪拌1小時。藉由TLC (PE:EtOAc=1:1)追蹤反應進程。將反應混合物藉由添加冰冷H 2O (200 mL)來淬滅，濃縮以移除大部分MeOH，且用EtOAc (200 mL×3)萃取。將合併之有機層用鹽水(400 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到C8 (7.5 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, CDCl 3) δ 8.27 (d, 1 H), 6.62-6.88 (m, 3 H), 4.94 (s, 2 H)。 步驟5：製備4-氟吡唑并[1,5-a]吡啶-2-甲醛(C9)
向(4-氟吡唑并[1,5-a]吡啶-2-基)甲醇(C8) (7.5 g, 45.1 mmol)在MeCN (150 mL)中之溶液中，添加IBX (15.17 g, 54.2 mmol, 1.2 eq)。將反應混合物在80℃下攪拌3小時。使用TLC (PE:EtOAc=5:1)檢查反應進程。將反應混合物過濾並濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至4% EtOAc/PE，梯度在40 mL/min下）純化，以得到C9（4 g，54%產率）。 1H NMR (400 MHz, CDCl 3) δ 10.22 (s, 1 H), 8.33-8.41 (m, 1 H), 7.20 (d, 1 H), 6.85-6.98 (m, 2 H)。
按照上文針對C9所述之一般程序，以2-溴-3-甲基吡啶開始製備中間物4-甲基吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-3-(三氟甲基)吡啶開始製備中間物4-(三氟甲基)吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-3-甲氧基吡啶開始製備中間物4-甲氧基吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-4-甲基吡啶開始製備中間物5-甲基吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-4-氟吡啶開始製備中間物5-氟吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以4-(三氟甲基)吡啶開始製備中間物5-(三氟甲基)吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-5-甲基吡啶開始製備中間物6-甲基吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-5-氟吡啶開始製備中間物6-氟吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C9所述之一般程序，以2-溴-5-(三氟甲基)吡啶開始製備中間物6-(三氟甲基)吡唑并[1,5-a]吡啶-2-甲醛。 中間物7-(三氟甲基)吡唑并[1,5-a]吡啶-2-甲醛 步驟1：製備1-胺基-2-(三氟甲基)吡啶-1-鎓2,4,6-三甲苯基磺酸酯(C11)
在0℃下，向TFA (215.60 g, 1.89 mol, 140 mL, 27.8 eq)及H 2O (20.00 g, 1.11 mol, 20.0 mL, 16.3 eq)之混合物中，添加(1E)-N-(2,4,6-三甲基苯基)磺醯氧基乙亞胺酸乙基酯(21.34 g, 74.8 mmol, 1.1 eq)，且將反應混合物在0℃下攪拌2小時。將反應藉由添加冰水(100 mL)來淬滅，且將沉澱物過濾，並用水(50 mL × 2)沖洗。然後將沉澱物溶解於DCM (140 mL)中，經Na 2SO 4乾燥並過濾。在0℃下，向濾液中，添加2-(三氟甲基)吡啶(C10) (10 g, 68.0 mmol, 7.87 mL)。將反應混合物溫熱至室溫，並攪拌16小時。將TBME (100 mL)緩慢添加至反應混合物中，且將沉澱物收集並用TBME (40 mL × 3)沖洗，且然後真空乾燥，以得到C11（8.5 g，35%產率），其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 9.06 (d, 1 H), 8.40-8.60 (m, 2 H), 8.20-8.26 (m, 1 H), 8.12 (s, 2 H), 6.60 (s, 2 H), 2.34 (s, 6 H), 2.02 (s, 3 H)。 步驟2：製備7-(三氟甲基)吡唑并[1,5-a]吡啶-2,3-二羧酸二甲基酯(C12)
在0℃下，向1-胺基-2-(三氟甲基)吡啶-1-鎓2,4,6-三甲基苯磺酸酯(C11) (8.5 g, 23.5 mmol)及K 2CO 3(6.49 g, 46.9 mmol, 2 eq)在DMF (100 mL)中之混合物中，添加丁-2-炔二酸二甲基酯(6.66 g, 46.9 mmol, 2 eq)，將反應混合物溫熱至室溫並攪拌16小時。藉由TLC (PE:EtOAc=1:1)追蹤反應進程。添加水(200 mL)，且將溶液攪拌30分鐘。將所得沉澱物藉由真空過濾進行收集，用水沖洗並乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至40% EtOAc:PE，在60 mL/min下）純化，以得到C12（2.85 g，40%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.40 (d, 1 H), 7.74-7.96 (m, 2 H), 3.85-3.96 (m, 6 H)。 步驟3：製備2-(甲氧基羰基)-7-(三氟甲基)吡唑并[1,5-a]吡啶-3-羧酸(C13)
向7-(三氟甲基)吡唑并[1,5-a]吡啶-2,3-二羧酸二甲基酯(C12) (2.85 g, 9.43 mmol)在THF (20 mL)中之溶液中添加H 2O (20 mL)中之LiOH.H 2O (1.58 g, 37.7 mmol, 4 eq)，且將反應混合物在室溫下攪拌16小時。使用TLC (PE:EtOAc=1:1)追蹤反應進程。將反應混合物真空濃縮以移除大部分THF，且用4 M HCl將水相調節至pH為約2。將沉澱物藉由過濾進行收集且接著真空乾燥，以得到C13 (2.25 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.43 (d, 1 H), 7.85 (d, 1 H), 7.71-7.76 (m, 1 H)。 步驟4：製備7-(三氟甲基)吡唑并[1,5-a]吡啶-2-羧酸(C14)
將2-(甲氧基羰基)-7-(三氟甲基)吡唑并[1,5-a]吡啶-3-羧酸(C13) (2.25 g, 8.21 mmol)在H 2SO 4(41.40 g, 422 mmol, 22.5 mL, 51.4 eq)及H 2O (11.25 g, 624 mmol, 11.3 mL, 76.1 eq)中之混合物在90℃下攪拌16小時。使用LC-MS追蹤反應進程。將反應混合物冷卻至室溫，且添加水(60 mL)。將沉澱物藉由過濾進行收集且接著真空乾燥，以得到C14 (1.7 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.14 (d, 1 H), 7.71 (d, 1 H), 7.41-7.49 (m, 1 H), 7.32 (s, 1 H)。 步驟5：製備N-甲氧基-N-甲基-7-(三氟甲基)吡唑并[1,5-a]吡啶-2-羧醯胺(C15)
向7-(三氟甲基)吡唑并[1,5-a]吡啶-2-羧酸(C14) (8.00 g, 34.8 mmol)及N-甲氧基甲胺(10.17 g, 104 mmol, 3 eq, HCl)在DMF (80 mL)中之溶液中，添加HOBt (7.05 g, 52.1 mmol, 1.5 eq)、EDCI (10.00 g, 52.1 mmol, 1.5 eq)及DIPEA (13.48 g, 104 mmol, 18.2 mL, 3 eq)。將混合物在室溫下攪拌16小時。使用TLC (DCM:MeOH =10:1)追蹤反應進程。添加DCM (150 mL)，且將有機部分用飽和Na 2CO 3溶液(100 mL × 2)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0至10% MeOH:DCM，在60 mL/min下）純化，以得到C15（6 g，60%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.11 (d, 1 H), 7.67 (d, 1 H), 7.37-7.49 (m, 1 H), 7.21 (s, 1 H), 3.77 (s, 3 H), 2.50-2.52 (m, 3 H)；LCMS: m/z 274.1 [M+H] +。 步驟6：製備7-(三氟甲基)吡唑并[1,5-a]吡啶-2-甲醛(C16)
在-78℃下在N 2下，向N-甲氧基-N-甲基-7-(三氟甲基)吡唑并[1,5-a]吡啶-2-羧醯胺(C15) (6 g, 22.0 mmol)在THF (60 mL)中之溶液中逐滴添加DIBAL-H (1 M, 65.9 mL, 3 eq)，且然後將反應混合物在-78℃下在N 2下攪拌2小時。使用TLC (PE:EtOAc=5:1)追蹤反應進程。將反應混合物藉由添加飽和NH 4Cl溶液(150 mL)淬滅，且然後添加4 MHCl溶液(80 mL)。將水性部分用EtOAc (100 mL × 2)萃取，且將合併之有機層用水(80 mL)及鹽水(80 mL)洗滌。將有機層經Na 2SO 4乾燥、過濾且蒸發至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至30% EtOAc:PE，在40 mL/min下）純化，以得到C16（3.95 g，68%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 10.20 (s, 1 H), 8.20 (d, 1 H), 7.79 (d, 1 H), 7.49 (dd, 1 H), 7.40 (s, 1 H)。
按照上文針對C16所述之一般程序，以2-氯吡啶開始製備中間物7-氯吡唑并[1,5-a]吡啶-2-甲醛。
按照上文針對C16所述之一般程序，以4-(三氟甲基)吡啶開始製備中間物5-(三氟甲基)吡唑并[1,5-a]吡啶-2-甲醛。 中間物7-氟吡唑并[1,5-a]吡啶-2-甲醛 步驟1：製備7-氟吡唑并[1,5-a]吡啶-2-羧酸乙基酯(C18)
向7-溴吡唑并[1,5-a]吡啶-2-羧酸乙基酯(C17) (1 g, 3.72 mmol)在DMA (8 mL)中之溶液中添加CsF (1.69 g, 11.2 mmol, 411 µL, 3 eq)，將反應混合物在微波下在150℃下攪拌1小時。使用LCMS追蹤反應進程。將DCM (60 mL)添加至反應混合物中，且將有機部分用水(30 mL)及鹽水(30 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至4/1）純化，以得到C18（450 mg，29%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.48 (d, 1 H), 7.18-7.26 (m, 2 H), 6.64 (ddd, 1 H), 4.52 (q, 2 H), 1.48 (t, 3 H)；LCMS: m/z 208.8 [M+H] +。 步驟2：製備(7-氟吡唑并[1,5-a]吡啶-2-基)甲醇(C19)
在0℃下，向7-氟吡唑并[1,5-a]吡啶-2-羧酸乙基酯(C18) (450 mg, 2.16 mmol)在THF (4 mL)及EtOH (2 mL)中之溶液中，添加LiBH 4(260 mg, 11.9 mmol, 5.5 eq)。將反應混合物在室溫下攪拌2小時。使用LCMS追蹤反應進程。將反應混合物藉由添加飽和NH 4Cl溶液(10 mL)來淬滅，且將水性部分用EtOAc (30 mL)萃取。將有機層用水(20 mL)及鹽水(20 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到C19 (360 mg)，其未經進一步純化即被使用。LCMS: m/z 167.0 [M+H] +。 步驟3：製備7-氟吡唑并[1,5-a]吡啶-2-甲醛(C20)
向(7-氟吡唑并[1,5-a]吡啶-2-基)甲醇(C19) (360 mg, 2.17 mmol)在MeCN (5 mL)中之溶液中添加IBX (971 mg, 3.47 mmol, 1.6 eq)，且將反應混合物在80℃下攪拌1小時。使用LCMS追蹤反應進程。將反應混合物過濾且濃縮至乾燥，以得到C20 (355 mg)，其未經進一步純化即被使用。 1H NMR (400 MHz, CDCl 3) δ 10.26-10.46 (m, 1 H), 7.52 (dd, 1 H), 7.22-7.28 (m, 1 H), 7.16 (d, 1 H), 6.69 (ddd, 1 H)；LCMS: m/z 165.0 [M+H] +。
根據一般方案4之中間物4-(二氟甲基)㗁唑-5-羧酸 步驟1：製備2-溴-4,4二氟-3-側氧基-丁酸乙基酯(E1)
在0℃下，向4,4二氟-3-側氧基-丁酸乙基酯(20 g, 120 mmol)在DCM (240 mL)中之溶液中，分批添加TsOH (4.15 g, 24.1 mmol, 0.2 eq)及NBS (22.50 g, 126 mmol, 1.05 eq)。添加完成後，將反應混合物在室溫下攪拌1小時。使用TLC (PE:EtOAc=5:1)檢查反應進程。添加DCM (100 mL)，且將有機部分用飽和Na 2CO 3溶液(100 mL)及鹽水(150 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到E1 (34 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 5.81-6.16 (m, 1 H), 4.34-4.41 (m, 1 H), 4.12-4.20 (m, 2 H), 1.17-1.23 (m, 3 H)。 步驟2：製備2-胺基-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E2)
將E1 (37 g, 151 mmol)及脲(45.34 g, 755 mmol, 40.5 mL, 5 eq)在DMF (30 mL)中之混合物在120℃下攪拌12小時。使用LC-MS檢查反應進程。將反應混合物冷卻至室溫且倒入100 mL水中。將反應混合物在0℃下攪拌15分鐘，且將沉澱物藉由過濾進行收集，用水(50 mL)沖洗，真空乾燥，以得到E2（15.5 g，步驟1及2之產率為63%）。LC‑MS：m/z 207.2 (M+H) +； 1H NMR (400 MHz, DMSO- d 6) δ 7.86 (s, 2 H), 6.84-7.44 (m, 1 H), 4.27 (q, 2 H), 1.28 (t, 3 H)。 步驟3：製備4-(二氟甲基)㗁唑-5-羧酸乙基酯(E3)
在0℃下，向2-胺基-4-(二氟甲基)㗁唑-5-羧酸乙基酯(20 g, 97.0 mmol)在THF (300 mL)中之溶液中，逐滴添加t-BuONO (30.01 g, 291 mmol, 34.6 mL, 3 eq)，將反應混合物在室溫下攪拌12小時。添加DCM (300 mL)，且將有機部分用水(200 mL)及鹽水(200 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至10/1）純化，以得到E3（12.7 g，69%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.05 (s, 1 H), 6.93-7.27 (m, 1 H), 4.44 (q, 2 H), 1.40 (t, 3 H)。 步驟5：製備4-(二氟甲基)㗁唑-5-羧酸(E4)
向4-(二氟甲基)㗁唑-5-羧酸乙基酯(12.7 g, 66.5 mmol)在THF (100 mL)及H 2O (20 mL)中之溶液中，添加LiOH.H 2O (3.07 g, 73.1 mmol, 1.1 eq)。將反應混合物在室溫下攪拌1小時且接著真空濃縮以移除THF。添加水(80 mL)，且將水性部分用TBME (50 mL)萃取。接著藉由添加0.5 MHCl將水層調節至pH為約6。將水層濃縮至乾燥，以得到E4 (11 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.30 (s, 1 H), 7.34-7.76 (m, 1 H)。
根據一般方案4之中間物2-溴-4-(二氟甲基)㗁唑-5-羧酸乙基酯 製備2-溴-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E5)
在0℃下，向2-胺基-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E2) (25 g, 121 mmol)在MeCN (200 mL)中之溶液中，添加CuBr 2(40.63 g, 182 mmol, 8.5 mL, 1.5 eq)。將混合物轉變成深綠色並在室溫下進一步攪拌15分鐘。在0℃下，添加t-BuONO (18.76 g, 182 mmol, 21.6 mL, 1.5 eq)。將反應在室溫下攪拌2小時且接著加熱至50℃並攪拌12小時。使用TLC (EtOAc:PE=5:1)追蹤反應進程。將反應混合物進行過濾。將DCM (200 mL)添加至濾液中，且將有機層用水(100 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；120 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至20% EtOAc/PE，梯度在100 mL/min下）純化，以得到E5（19 g，58%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.02 (t, 1 H), 4.39 (q, 2 H), 1.35 (t, 3 H)。
根據一般方案6方法A之中間物4-(二氟甲基)-2-(1-羥基-1-甲基-乙基)㗁唑-5-羧酸 步驟1：製備2-乙醯基-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E6)
向2-溴-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E5) (10 g, 37.0 mmol)在甲苯(150 mL)中之溶液中，添加Pd(PPh 3) 2Cl 2(2.60 g, 3.70 mmol, 0.1eq)及三丁基(1-乙氧基乙烯基)錫烷(17.39 g, 48.1 mmol, 16.3 mL, 1.3 eq)。在N 2氣氛下在85℃下將混合物攪拌12小時。使用TLC (PE:EtOAc)檢查反應進程。將EtOAc (100 mL)添加至反應混合物中，並將有機部分用飽和KF溶液(150 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物溶解在THF (60 mL)中且用HCl (4 M, 60 mL)處理且接著在40℃下攪拌12小時。藉由TLC（石油醚:EtOAc=10:1）檢查反應進程。將EtOAc (100 mL)添加至反應混合物中，且將有機部分用水(50 mL)及鹽水(50 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至20% EtOAc/PE，梯度在40 mL/min下）純化，以得到E6（7.1 g，82%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.00-7.36 (m, 1 H), 4.48 (q, 2 H), 2.66-2.86 (m, 3 H), 1.43 (t, 3 H)。 步驟2：製備4-(二氟甲基)-2-(1-羥基-1-甲基-乙基)㗁唑-5-羧酸乙基酯(E7)
在-78℃下向E6 (2.5 g, 10.7 mmol)在THF (120 mL)中之溶液中添加MeMgBr (3 M, 7.15 mL, 2 eq)。將混合物在-78℃下攪拌1小時。藉由TLC (PE:EtOAc=2:1)檢查反應進程。將反應混合物藉由添加飽和NH 4Cl溶液(50 mL)淬滅，且然後添加水(100 mL)。將水性部分用EtOAc (100 mL×3)萃取。將合併之有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至12% EtOAc/PE，梯度在40 mL/min下）純化，以得到E7（3.2 g，60%產率）。 1H NMR (400 MHz, CDCl 3) δ 6.94-7.29 (m, 1 H), 4.46 (q, 2 H), 2.86 (s, 1 H), 1.72 (s, 6 H), 1.44 (t, 3 H)。亦回收起始材料E6 (300 mg)。 步驟3：製備4-(二氟甲基)-2-(1-羥基-1-甲基-乙基)㗁唑-5-羧酸(E8)
向E7 (3.9 g, 15.7 mmol)在THF (40 mL)及H 2O (40 mL)中之溶液中，添加LiOH.H 2O (690 mg, 16.4 mmol, 1.05 eq)。在室溫下將混合物攪拌1小時。使用TLC (PE:EtOAc=5:1)檢查反應進程。將反應混合物濃縮以移除THF。藉由添加1 M HCl將水性混合物調節至pH為約3，且然後真空凍乾，以得到E8 (4 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 7.35-7.71 (m, 1 H), 5.68 (br s, 1 H), 1.50 (s, 6 H)。 中間物2-(1-羥基環丁基)-4-(三氟甲基)㗁唑-5-羧酸 步驟1：製備4-(三氟甲基)㗁唑-5-羧酸乙基酯(E10)
向2-胺基-4-(三氟甲基)㗁唑-5-羧酸乙基酯(2.00 g, 8.92 mmol)在THF (60 mL)中之溶液中，添加t-BuONO (1.84 g, 17.9 mmol, 2.12 mL, 2 eq)。將反應混合物在55℃下攪拌24小時。將EtOAc (120 mL)添加至反應混合物中，且將有機部分用水(100 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至8/1）純化，以得到E10（1.2 g，64%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.96 (s, 1 H), 4.39 (q, 2 H), 1.34 (t, 3 H)。 步驟2：製備2-(1-羥基環丁基)-4-(三氟甲基)㗁唑-5-羧酸乙基酯(E11)
在-78℃下向4-(三氟甲基)㗁唑-5-羧酸乙基酯(1.2 g, 5.74 mmol)在THF (30 mL)中之溶液中，添加LiHMDS (1 M, 8.61 mL, 1.5 eq)，且將反應混合物在-78℃下攪拌0.5小時。將THF (5 mL)中之環丁酮(1.21 g, 17.2 mmol, 1.29 mL, 3 eq)添加至反應混合物中，且將混合物在-78℃下在N 2氣氛下攪拌2小時。將反應混合物藉由添加飽和NH 4Cl溶液(30 mL)淬滅，且將水性部分用EtOAc (100 mL)萃取。將有機層藉由水(70 mL)及鹽水(70 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至10/1）純化，以得到E11（600 mg，37%產率）。 1H NMR (400 MHz, CDCl 3) δ 4.29 (q, 2 H), 2.78-2.94 (m, 1 H), 2.52-2.65 (m, 2 H), 2.24-2.38 (m, 2 H), 1.78-1.98 (m, 3 H), 1.26 (t, 3 H)。 步驟3：製備2-(1-羥基環丁基)-4-(三氟甲基)㗁唑-5-羧酸(E12)
在0℃下，向2-(1-羥基環丁基)-4-(三氟甲基)㗁唑-5-羧酸乙基酯(600 mg, 2.15 mmol)在H 2O (2 mL)及THF (10 mL)中之溶液中，添加LiOH.H 2O (99.2 mg, 2.36 mmol, 1.1 eq)。將反應混合物在室溫下攪拌2小時且真空濃縮以移除THF。添加水(10 mL)，且將水性部分用TBME (30 mL)萃取。接著藉由添加0.5 MHCl將水層調節至pH為約6，且濃縮至乾燥，以得到E12 (540 mg)，其未經進一步純化即被使用。 1H NMR (400 MHz, CD 3OD) δ 2.54-2.67 (m, 2 H), 2.19-2.34 (m, 2 H), 1.81-1.95 (m, 1 H), 1.66-1.80 (m, 1 H)。
根據一般方案6之中間物4-溴-2-(2-羥基丙-2-基)㗁唑-5-羧酸乙基酯 步驟1：製備4-溴㗁唑-5-羧酸乙基酯(E14)
在約10℃下在THF (2.50 mL)及DMF (2.50 mL)中添加㗁唑-5-羧酸乙基酯(E13) (500 mg, 3.54 mmol)。將反應混合物冷卻至-80℃且在約-80℃下逐滴添加LiHMDS (1 M, 4.61 mL, 1.30 eq)。在約-80℃下將反應混合物攪拌0.5小時。接著在約-80℃下逐滴添加Br 2(736 mg, 4.61 mmol, 1.3 eq)。在約-80℃下將反應混合物攪拌0.5小時。使用LC-MS檢查反應進程。將反應混合物與19種使用500 mg E13進行之其他反應合併。在約-10℃下將合併之反應混合物倒入飽和檸檬酸中。將水性部分用EtOAc (50 mL × 3)萃取。將合併之有機層用鹽水(50 mL)洗滌，用Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至0/1）純化，以得到E14（3.00 g，19%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ 8.70 (s, 1 H), 4.29-4.34 (m, 2 H), 1.29 (t, 3 H)；LC‑MS：m/z 219.9 & 221.9 (M+H) +。 步驟2：製備4-溴-2-碘㗁唑-5-羧酸乙基酯(E15)
在室溫下在THF (15.0 mL)中添加4-溴㗁唑-5-羧酸乙基酯(E14) (3.15 g, 14.3 mmol, 1.00 eq)。在約-80℃下逐滴添加LiHMDS (1 M, 17.2 mL, 1.20 eq)。在約-80℃下逐滴添加THF (15.0 mL)中之I 2(5.45 g, 21.5 mmol, 1.50 eq)。在約-80℃下將反應混合物攪拌1小時。使用TLC (PE/EtOAc)檢查反應進程。將反應混合物在約-10℃下倒入飽和檸檬酸(30 mL)中。將水相用乙酸乙酯(30 mL × 3)萃取。將合併之有機層用鹽水(30 mL)洗滌，用Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至0/1）純化，以得到E15（1.10 g，22%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ: 4.29-4.35 (m, 2H), 1.30 (t, 3H)。LC‑MS：m/z 345.8 & 347.9 (M+H) +。 步驟3：製備4-溴-2-(2-羥基丙-2-基)㗁唑-5-羧酸乙基酯(E16)
在THF (10 mL)中在約10℃下在N 2下，添加4-溴-2-碘㗁唑-5-羧酸乙基酯(E15) (1.10 g, 3.18 mmol)。將反應混合物真空除氣且用N 2吹掃三次。將混合物冷卻至-80℃且在約-80℃下逐滴添加iPr-MgCl.LiCl (1.3 M, 2.45 mL, 1 eq)。在約-80℃下將反應混合物攪拌0.5小時，且隨後在約-80℃下逐滴添加丙酮(222 mg, 3.82 mmol, 1.20 eq)。在約-80℃下將混合物攪拌0.5小時。使用TLC (PE/EtOAc=5/1)檢查反應進程。將反應混合物在約-10℃下倒入飽和檸檬酸溶液(5 mL)中。將水性部分用乙酸乙酯(5 mL × 3)萃取。將合併之有機層用鹽水(5 mL)洗滌，用Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至0/1）純化，且藉由製備型HPLC（管柱：Phenomenex luna C18 80 × 40 mm × 3 um；移動相：[水(0.04% HCl)-ACN]；B%: 18%-45%，7 min）進一步純化，以得到E16（140 mg，16%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ: 5.93 (s, 1H), 4.30 – 4.37 (m, 2H), 1.50 (s, 6H), 1.32 (t, 3H)。LC‑MS：m/z 277.9 & 279.9 (M+H) +。
根據一般方案6之中間物4-氯-2-(2-羥基丙-2-基)㗁唑-5-羧酸乙基酯 步驟1：製備4-氯㗁唑-5-羧酸乙基酯(E17)
在約10℃下在DMF (50 mL)中添加㗁唑-5-羧酸乙基酯(E13) (10.0 g, 70.9 mmol)。將反應混合物冷卻至-80℃且在約-80℃下逐滴添加LiHMDS (1 M, 92.1 mL, 1.3 eq)。在約-80℃下將反應混合物攪拌0.5小時，且隨後在約-80℃下逐滴添加THF (50 mL)中之NCS (12.3 g, 92.1 mmol, 1.3 eq)。在約-80℃下將混合物攪拌0.5小時。使用TLC (PE/EtOAc=5/1)檢查反應進程。將反應混合物與七種使用10 g E13進行之其他反應合併用於後處理。將合併之反應混合物在約-10℃下倒入飽和檸檬酸溶液(100 mL)中。將水性部分用乙酸乙酯(100 mL×3)萃取。將合併之有機層用鹽水(50 mL)洗滌，用Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至0/1）純化，以得到E17（18.0 g，18%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.94 (s, 1 H), 4.44 (q, 2 H), 1.42 (t, 3 H)；LC‑MS：m/z 176.0 (M+H) +。 步驟2：製備4-氯-2-碘㗁唑-5-羧酸乙基酯(E18)
三個反應平行進行。將4-氯㗁唑-5-羧酸乙基酯(E17) (6.00 g, 34.2 mmol)在室溫下溶解於THF (30 mL)中。在約-80℃下，逐滴添加LiHMDS (1 M, 41.0 mL, 1.2 eq)，接著在約-80℃下逐滴添加THF (30 mL)中之I 2(13.0 g, 51.3 mmol, 1.5eq)。在約-80℃下將反應混合物攪拌1小時。使用TLC (PE/EtOAc=5/1)檢查反應進程。將三個平行反應合併在一起以用於後處理。將合併之反應混合物在約-5℃下倒入飽和檸檬酸溶液(100 mL)中。將水性部分用乙酸乙酯(100 mL × 3)萃取。將合併之有機層用鹽水(50 mL)洗滌，用Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至0/1）純化，以得到E18（10.0 g，32%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ 4.20 – 4.27 (m, 2 H), 1.21 (t, 3 H)；LC‑MS：m/z 301.9 (M+H) +。 步驟3：製備4-氯-2-(2-羥基丙-2-基)㗁唑-5-羧酸乙基酯(E19)
兩個反應平行進行。在THF (50 mL)中在約10℃下在N 2下，添加化合物E18 (5.00 g, 16.6 mmol)。將懸浮液進行真空除氣且用N 2吹掃三次。將混合物冷卻至-80℃且在約-80℃下逐滴添加iPr-MgCl.LiCl (1.3 M, 12.8 mL, 1 eq)。在約-80℃下將混合物攪拌0.5小時，且隨後在約-80℃下逐滴添加丙酮(1.16 g, 19.9 mmol, 1.2 eq)。在約-80℃下將混合物攪拌0.5小時。使用TLC (PE/EtOAc=5/1)檢查反應進程。將兩個平行反應合併在一起以用於後處理。將合併之反應混合物在約-10℃下倒入飽和檸檬酸溶液(50 mL)中。將水性部分用乙酸乙酯(50 mL×3)萃取。將合併之有機層用鹽水(50 mL)洗滌，用Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至0/1）純化，且藉由製備型HPLC（管柱：Phenomenex luna C18 (250 × 70 mm × 15 um)；移動相：[水(0.05% HCl)-ACN]；B%: 20%-50%，23 min）進一步純化，以得到E19（1.80 g，23%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ: 5.92 (s, 1H), 4.32 – 4.37 (m, 2H), 1.51 (s, 6H), 1.31 (t, 3H)；LC‑MS：m/z 234.0 (M+H) +。 中間物4-(二氟甲基)-2-(2-氰基丙-2-基)㗁唑-5-羧酸 步驟1：製備2-氰基-2-甲基-丙醯氯(E20)
在0℃下，向2-氰基-2-甲基-丙酸(2 g, 17.7 mmol)及DMF (129 mg, 1.77 mmol, 136 µL, 0.1 eq)在DCM (20 mL)中之溶液中，添加草醯氯(2.69 g, 21.2 mmol, 1.86 mL, 1.2 eq)，且隨後在室溫下將反應混合物攪拌1小時。將反應混合物濃縮至乾燥，以得到E20 (2.5 g)，其未經進一步純化即被使用。 步驟2：製備(Z)-3-[(2-氰基-2-甲基-丙醯基)胺基]-4,4-二氟-丁-2-烯酸乙基酯(E21)
在室溫下，向(Z)-3-胺基-4,4-二氟-丁-2-烯酸乙基酯(2 g, 12.1 mmol)在二㗁烷(20 mL)中之溶液中，添加2-氰基-2-甲基-丙醯氯(E20) (2.39 g, 18.2 mmol, 1.5 eq)在二㗁烷(20 mL)中之溶液。將反應混合物在110℃下攪拌12小時。使用TLC（PE/乙酸乙酯=5/1）檢查反應進程。將反應混合物濃縮至乾燥，且將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至7% EtOAc/PE，梯度在40 mL/min下）純化，以得到E21（2.4 g，76%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 10.90 (s, 1 H), 6.95-7.27 (m, 1 H), 5.81 (s, 1 H), 4.12-4.29 (m, 2 H), 1.51-1.69 (m, 6 H), 1.20 (t, 3 H)；LCMS: m/z 259.1 [M+H] +。 步驟3：製備2-(1-氰基-1-甲基-乙基)-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E22)
在室溫下，向(Z)-3-[(2-氰基-2-甲基-丙醯基)胺基]-4,4-二氟-丁-2-烯酸乙基酯(E21) (2.4 g, 9.22 mmol)在DCE (20 mL)中之溶液中，添加BF 3.Et 2O (2.62 g, 18.4 mmol, 2.28 mL, 2 eq)及PIDA (4.16 g, 12.9 mmol, 1.4 eq)。將混合物在90℃下攪拌18小時。藉由TLC (PE/EtOAc)檢查反應進程。將反應混合物濃縮至乾燥。將DCM (100 mL)添加至殘餘物中，且將有機層用飽和Na 2CO 3溶液(10 mL)及鹽水(50 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；12 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至7% EtOAc/PE，梯度在30 mL/min下）純化，以得到E22（0.25 g，11%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 7.03-7.55 (m, 1 H), 4.35 (q, 2 H), 1.77 (s, 6 H), 1.29 (t, 3 H)。 步驟4：製備2-(1-氰基-1-甲基-乙基)-4-(二氟甲基)㗁唑-5-羧酸(E23)
向2-(1-氰基-1-甲基-乙基)-4-(二氟甲基)㗁唑-5-羧酸乙基酯(E22) (0.25 g, 968 µmol)在THF (3 mL)及H 2O (1 mL)中之溶液中，添加LiOH.H 2O (48.8 mg, 1.16 mmol, 1.2 eq)。將混合物在室溫下攪拌18小時。使用TLC (PE:EtOAc=5:1)檢查反應完全性。將反應混合物在減壓下濃縮以移除THF。將水性部分用2 MHCl調節至pH為約7，且接著真空凍乾，以得到E23（0.22 g，99%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 7.23-7.74 (m, 1 H), 1.73 (s, 6 H)。
根據一般方案5方法B之中間物4-(二氟甲基)-2-(嘧啶-2-基)㗁唑-5-羧酸 步驟1：製備4-(二氟甲基)-2-嘧啶-2-基-㗁唑-5-羧酸乙基酯(E24)
在N 2氣氛下，向4-(二氟甲基)㗁唑-5-羧酸乙基酯(E4) (1 g, 5.23 mmol)、Pd 2(dba) 3(240 mg, 262 µmol, 0.05 eq)、(5-二苯基膦基-9,9-二甲基-氧雜蒽-4-基)-二苯基-膦烷(151 mg, 262 µmol, 0.05 eq)及Cs 2CO 3(3.41 g, 10.5 mmol, 2 eq)在1,2-二甲氧基乙烷(3 mL)中之溶液中，添加2-氯嘧啶(599 mg, 5.23 mmol)。將反應混合物在90℃下攪拌12小時。將DCM (50 mL)添加至反應混合物中，且將有機部分用水(40 mL)及鹽水(40 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至1/1）純化，以得到E24（400 mg，25%產率）。 1H NMR (400 MHz, CDCl 3) δ 9.02 (br d, 2 H), 7.52 (t, 1 H), 7.38 (s, 1 H), 7.24 (s, 1 H), 7.11 (s, 1 H), 4.54 (q, 2 H), 1.48 (t, 3 H)。 步驟2：製備4-(二氟甲基)-2-嘧啶-2-基-㗁唑-5-羧酸(E25)
向4-(二氟甲基)-2-嘧啶-2-基-㗁唑-5-羧酸乙基酯(E24) (450 mg, 1.67 mmol)在THF (2 mL)及H 2O (2 mL)中之溶液中，添加LiOH.H 2O (77.2 mg, 1.84 mmol, 1.1 eq)。在室溫下將反應混合物攪拌1小時。將反應混合物濃縮以移除THF，且添加H 2O (10 mL)。將水層用TBME (30 mL)萃取。隨後將水層用0.5 MHCl調節至pH為約6，且用DCM/MeOH (30/3 mL)萃取3次。將合併之DCM/MeOH有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到E25 (350 mg)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 9.06 (d, 2 H), 7.75 (t, 1 H), 7.20-7.57 (m, 1 H)。
根據一般方案4及一般方案6方法A之中間物2-(1-羥基-1-甲基-乙基)-4-甲基-㗁唑-5-羧酸 步驟1：製備2-胺基-4-甲基-㗁唑-5-羧酸乙基酯(E26)
將乙基2-氯-3-側氧基-丁酸酯(55 g, 334 mmol, 46.2 mL)及脲(100.34 g, 1.67 mol, 89.6 mL, 5 eq)在DMF (100 mL)中之混合物在120℃下攪拌12小時。使用TLC (PE:EtOAc=5:1)檢查反應進程。將反應混合物冷卻至室溫，倒入H 2O (400 mL)中並在0℃下攪拌30分鐘。將固體藉由過濾進行收集，用水(30 mL)沖洗，且隨後真空乾燥，以得到E26（22.2 g，39%產率）。 1H NMR (400 MHz, CD 3OD) δ 4.29 (q, 2 H), 2.32 (s, 3 H), 1.35 (t, 3 H)。 步驟2：製備2-溴-4-甲基-㗁唑-5-羧酸乙基酯(E27)
在0℃下，向E26 (11.1 g, 65.2 mmol)在MeCN (120 mL)中之溶液中，添加CuBr 2(21.85 g, 97.9 mmol, 4.58 mL, 1.5 eq)。混合物轉變為深綠色，且在室溫下進一步攪拌15分鐘。添加t-BuONO (10.09 g, 97.9 mmol, 11.6 mL, 1.5 eq)。將反應在室溫下攪拌2小時且接著在50℃下加熱4小時。使用TLC（石油醚:EtOAc=3:1）檢查反應進程。將反應混合物濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；120 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至5% EtOAc/PE，梯度在100 mL/min下）純化，以得到E27（8.5 g，56%產率）。 1H NMR (400 MHz, CDCl 3) δ 4.25-4.35 (m, 2 H), 2.45 (s, 3 H), 1.32 (t, 3 H)。 步驟3：製備2-乙醯基-4-甲基㗁唑-5-羧酸乙基酯(E28)
將E27 (9.5 g, 40.6 mmol)、三丁基(1-乙氧基乙烯基)錫烷(17.59 g, 48.7 mmol, 16.4 mL, 1.2 eq)及Pd(PPh 3) 2Cl 2(2.85 g, 4.06 mmol, 0.1 eq)在甲苯(200 mL)中之混合物在90℃下在N 2氣氛下攪拌12小時。使用TLC（石油醚:EtOAc=5:1）檢查反應進程。添加EtOAc (300 ml)，接著添加飽和KF溶液(500 ml)。將所得混合物在室溫下攪拌40分鐘，將混合物過濾，且將濾液分離。將有機層用鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物溶解於THF (300 ml)中，且添加4 N HCl (300 ml)。將混合物在室溫下攪拌12小時。LCMS指示偵測到所欲質量。將反應混合物用DCM (100 mL×3)萃取。將合併之有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；24 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至10% EtOAc/PE，梯度在35 mL/min下）純化，以得到E28（6.8 g，85%產率）。 1H NMR (400 MHz, CDCl 3) δ 4.35 (q, 2 H), 2.62 (s, 3 H), 2.48 (s, 3 H), 1.34 (t, 3 H); LCMS: m/z 198.1 (M+H) +。 步驟4：製備2-(2-羥基丙-2-基)-4-甲基㗁唑-5-羧酸乙基酯(E29)
在N 2下在-78℃下，向E28 (2.5 g, 12.7 mmol)在THF (25 mL)中之溶液中，逐滴添加MeMgBr (3 M, 12.7 mL, 3 eq)。將反應在-78℃下攪拌1.5小時。使用TLC（石油醚:EtOAc=5:1，藉由UV）檢查反應進程。將反應藉由緩慢添加飽和NH 4Cl溶液(30 mL)淬滅，且然後將有機部分用EtOAc (30 mL × 3)萃取。將合併之有機相用鹽水(30 mL)洗滌，經Na 2SO 4乾燥、過濾並濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，石油醚/EtOAc=1/0至1/1）純化，以得到E29（1.7 g，63%產率）。 1H NMR (400 MHz, CDCl 3) δ 4.39 (q, 2 H), 2.47 (s, 3 H), 1.67 (s, 6 H), 1.40 (t, 3 H)。
替代地，可藉由使2-羥基-2-甲基丙醯胺與2-氯-3-側氧基-丁酸乙基酯在純反應中在150℃下反應6小時來製備E29。 步驟5：製備乙基2-(2-羥基丙-2-基)-4-甲基㗁唑-5-羧酸(E30)
向E29 (3.4 g, 16.0 mmol)在THF (30 mL)及H 2O (15 mL)中之溶液中，添加LiOH.H 2O (803 mg, 19.1 mmol, 1.2 eq)。將反應在室溫下攪拌1.5小時。使用LCMS追蹤反應進程。將反應混合物用HCl (1 M)調節至pH 7並濃縮至乾燥，以得到E30 (4 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6 ) δ 5.67 (s, 1 H), 2.30 (s, 2 H), 1.44 (s, 6 H); LCMS: m/z 186.1 (M+H) +。
根據一般方案4之中間物4-環丙基-2-(2-羥基丙-2-基)㗁唑-5-羧酸 步驟1：製備2-溴-3-環丙基-3-側氧基-丙酸乙基酯(E31)
向3-環丙基-3-側氧基-丙酸乙基酯(8 g, 51.2 mmol)在DCM (100 mL)中之溶液中，添加NBS (9.12 g, 51.2 mmol)及TsOH.H 2O (1.95 g, 10.2 mmol, 0.2 eq)。將反應混合物在室溫下攪拌2小時。使用TLC (PE:EtOAc=10:1)追蹤反應進程。將反應混合物濃縮至乾燥。將EtOAc (120 mL)添加至殘餘物中，將混合物過濾。將濾液用飽和NaHCO 3溶液(2 × 100 mL)及水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1:0至10:1）純化，以得到E31（12 g，100%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 5.71 (s, 1 H), 4.18 (q, 2 H), 2.14-2.28 (m, 1 H), 1.18 (t, 3 H), 1.01-1.08 (m, 2 H), 0.89-0.96 (m, 2 H)；LCMS: m/z 235.0 [M+H] +。 步驟2：製備4-環丙基-2-(1-羥基-1-甲基-乙基)㗁唑-5-羧酸乙基酯(E32)
向2-溴-3-環丙基-3-側氧基-丙酸乙基酯(E31) (1 g, 4.25 mmol)在DMF (2 mL)中之溶液中，添加2-羥基-2-甲基-丙醯胺(2.19 g, 21.3 mmol, 5 eq)。將混合物在110℃下攪拌40小時。使用LC-MS追蹤反應進程。將反應混合物藉由在0℃下添加飽和NaHCO 3而調節至pH為約8。添加H 2O (50 mL)，且將水性部分用EtOAc (3 × 50 mL)萃取。將合併之有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1:0至2:1）純化，以得到E32（0.15 g，14%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 5.70 (s, 1 H), 4.29 (q, 2 H), 2.40-2.45 (m, 1 H), 1.43 (s, 6 H), 1.27 (t, 3 H), 0.94-1.04 (m, 2 H), 0.79-0.92 (m, 2 H)；LCMS: m/z 240.0 [M+H] +。 步驟3：製備4-環丙基-2-(1-羥基-1-甲基-乙基)㗁唑-5-羧酸(E33)
向4-環丙基-2-(1-羥基-1-甲基-乙基)㗁唑-5-羧酸乙基酯(E32) (590 mg, 2.47 mmol)在THF (4 mL)及H 2O (4 mL)中之溶液中，添加LiOH.H 2O (114 mg, 2.71 mmol, 1.1 eq)。將反應混合物在室溫下攪拌16小時。使用LC-MS追蹤反應進程。將反應混合物濃縮以移除THF。將水性部分藉由添加HCl (1 M)而調節至pH為約7，且接著凍乾以得到E33（550 mg，90%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 2.70-2.84 (m, 1 H), 1.39 (s, 6 H), 0.62-0.81 (m, 4 H)；LCMS: m/z 212.0 [M+H] +。 中間物4-氰基㗁唑-5-羧酸 步驟1：製備4-氰基㗁唑-5-羧酸乙基酯(E34)
向4-溴㗁唑-5-羧酸乙基酯(E14) (10 g, 45.5 mmol)在THF (30 mL)及H 2O (150 mL)中之溶液中，添加Zn(CN) 2(3.74 g, 31.8 mmol, 2.02 mL, 0.7 eq)及t-BuXPhos-Pd-G3 (1.81 g, 2.27 mmol, 0.05 eq)。將反應混合物真空除氣且用N 2吹掃3次，且隨後將混合物在40℃下在N 2下攪拌16小時。使用TLC (PE:EtOAc=5:1)追蹤反應進程。將EtOAc (300 mL)添加至反應混合物中，且將有機層用H 2(50 mL)及鹽水(50 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=100/1至10/1）純化，以得到E34（7.5 g，99%產率）。 1H NMR (400 MHz, DMSO- d 6 ) δ 8.89 (s, 1 H), 4.37 (q, 2 H), 1.30 (t, 3 H)。 步驟2：製備(4-氰基㗁唑-5-羰基)氧鋰(E35)
向E34 (5 g, 30.1 mmol)在THF (40 mL)及H 2O (80 mL)中之溶液中，添加LiOH.H 2O (1.33 g, 31.6 mmol, 1.05 eq )。將混合物在室溫下攪拌2小時。使用TLC (PE:EtOAc=5:1)追蹤反應進程。將反應混合物真空濃縮以移除大部分THF且接著真空凍乾，以得到E35 (4.5 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6 ) δ 8.47 (s, 1 H)。
根據一般方案9之中間物[5-[1-(2,2,2-三氟乙基)吡唑-4-基]-1,3,4-㗁二唑-2-羰基]氧鋰 步驟1：製備5-甲基硫烷基-1,3,4-㗁二唑-2-羧酸乙基酯(E36)
將2-肼基-2-側氧基-乙酸乙基酯(16 g, 121 mmol)及二(1H-咪唑-1-基)甲硫酮(25.90 g, 145 mmol, 1.2 eq)在THF (300 mL)中之混合物在室溫下攪拌12小時，且然後加熱至75℃持續4小時。冷卻至室溫後，添加K 2CO 3(50.21 g, 363 mmol, 3 eq)及CH 3I (85.95 g, 606 mmol, 37.7 mL, 5 eq)。將所得混合物在室溫下攪拌2小時。使用TLC (PE:EtOAc=1:1)追蹤反應進程。將反應混合物與用8.5 g 2-肼基-2-側氧基-乙酸乙基酯進行之另一反應合併，且藉由添加H 2O (100 mL)來淬滅。添加DCM (500 mL)，且將有機層分離且用鹽水(2 × 100 mL)洗滌，經Na 2SO 4乾燥、過濾，且濃縮至乾燥。將殘餘物藉由快速矽膠層析（洗提液為0%至25% PE:EtOAc，在40 mL/min下）純化，以得到E36 (25 g)。 1H NMR (400 MHz, CDCl 3) δ 4.43 (q, 2 H), 2.72 (s, 3 H), 1.38 (t, 3 H)。 步驟2：製備5-[1-(2,2,2-三氟乙基)吡唑-4-基]-1,3,4-㗁二唑-2-羧酸乙基酯(E37)
將E36 (233 mg, 1.24 mmol)、4-(4,4,5,5-四甲基-1,3,2-二氧雜硼雜環戊-2-基)-1-(2,2,2-三氟乙基)吡唑(410 mg, 1.49 mmol, 1.2 eq)、Na 2CO 3(394 mg, 3.71 mmol, 3 eq)、噻吩-2-羰基氧銅(472 mg, 2.48 mmol, 2 eq)及Pd(dppf)Cl 2(181 mg, 248 µmol, 0.2 eq)在二㗁烷(9 mL)中之混合物除氣且用N 2吹掃3次，且然後將反應混合物在75℃下在N 2下攪拌16小時。使用TLC (PE:EtOAc=2:1)追蹤反應進程。將EtOAc (100 mL)添加至反應混合物中，且將有機層用水(30 mL)及鹽水(30 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至2/1）純化，以得到E37（140 mg，39%產率）。 1H NMR (400 MHz, CD 3OD) δ 8.61 (s, 1 H), 8.22 (s, 1 H), 5.12 (q, 2 H), 4.51 (q, 2 H), 1.44 (t, 3 H)；LCMS: m/z 291.1 (M+H) +。 步驟3：製備[5-[1-(2,2,2-三氟乙基)吡唑-4-基]-1,3,4-㗁二唑-2-羰基]氧鋰(E38)
向E37 (140 mg, 482 µmol)在THF (1.5 mL)中之溶液中，添加H 2O (3 mL)中之LiOH.H 2O (22.3 mg, 531 µmol, 1.1 eq)。將反應混合物在室溫下攪拌2小時。使用TLC (DCM:MeOH)追蹤反應進程。將反應混合物真空濃縮以移除大部分THF且接著真空凍乾，以得到E38 (115 mg)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6 ) δ 8.58 (s, 1 H), 8.14 (s, 1 H), 5.27 (q, 2 H)。
替代地，可根據以下方案製備5-[1-(2,2,2-三氟乙基)吡唑-4-基]-1,3,4-㗁二唑-2-羧酸乙基酯(E37)。 步驟A：製備1-(2,2,2-三氟乙基)吡唑-4-羧酸乙基酯(E39)
向1H-吡唑-4-羧酸乙基酯(10 g, 71.4 mmol)及K 2CO 3(19.72 g, 142 mmol, 2 eq)在DMF (45 mL)中之溶液中，逐滴添加2,2,2-三氟乙基三氟甲磺酸酯(21.53 g, 92.8 mmol, 1.3 eq)，且隨後在50℃下將所得混合物攪拌6小時。使用TLC (PE:EtOAc=1:1)追蹤反應進程。將EtOAc (300 mL)添加至反應混合物中，且將有機層用H 2O (100 mL)及鹽水(2 × 100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至12% PE/EtOAc，在60 mL/min下）純化，以得到E39 (16 g)。 1H NMR (400 MHz, CDCl 3) δ 8.01 (d, 2 H), 4.73 (q, 2 H), 4.32 (q, 2 H), 1.36 (t, 3 H)。 步驟B：製備1-(2,2,2-三氟乙基)吡唑-4-碳醯肼(E40)
向E39 (16 g, 72.0 mmol)在THF (100 mL)中之溶液中添加NH 2NH 2.H2O（7.73 g，151 mmol，7.5 mL，98%純度，2.1 eq），且隨後在80℃下將反應混合物攪拌15小時。使用TLC (PE:EtOAc=1:1)追蹤反應進程。將反應混合物濃縮至乾燥。將殘餘物用TBME (50 mL)磨碎並攪拌15分鐘。將沉澱物藉由過濾收集且隨後真空乾燥，以得到E40 (13 g)。 1H NMR (400 MHz, CD 3OD) δ 8.19 (s, 1 H), 7.93 (s, 1 H), 4.98 (q, 2 H)。 步驟C：製備N-[[1-(2,2,2-三氟乙基)吡唑-4-羰基]胺甲酸乙基酯(E41)
在0℃下，向E40 (3 g, 14.4 mmol)在THF (70 mL)中之溶液中，逐滴添加2-氯-2-側氧基-乙酸乙基酯(2.36 g, 17.3 mmol, 1.9 mL, 1.2 eq)，且隨後在室溫下將反應混合物攪拌3小時。將沉澱物藉由過濾進行收集，且用TBME (30 mL)沖洗，且隨後真空乾燥，以得到E41（1.5 g，37%產率）。 1H NMR (400 MHz, CDCl 3) δ 9.75 (br s, 1 H), 9.06 (br s, 1 H), 8.25 (s, 1 H), 7.99 (s, 1 H), 4.76 (q, 2 H), 4.42 (q, 2 H), 1.42 (t, 3 H)。 步驟D：製備5-[1-(2,2,2-三氟乙基)吡唑-4-基]-1,3,4-㗁二唑-2-羧酸乙基酯(E37)
在0℃下，向E41 (1.5 g, 5.35 mmol)及Et 3N (271 mg, 2.68 mmol, 373 µL, 0.5 eq)在DCM (30 mL)中之溶液中，分批添加TsCl (491 mg, 6.96 mmol, 1.3 eq)，且然後將所得混合物在室溫下攪拌18小時。使用TLC (PE:EtOAc=1:1)追蹤反應進程。將DCM (100 mL)添加至反應混合物中，且將有機層用飽和Na 2CO 3溶液(60 mL)及鹽水(60 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至16% PE/EtOAc，在40 mL/min下）純化，以得到E37（0.65 g，42%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.16-8.29 (m, 2 H), 4.80 (q, 2 H), 4.53 (q, 2 H), 1.47 (t, 3 H)。
根據一般方案10之中間物鋰5- 啉-1,3,4-㗁二唑-2-羧酸酯 步驟1：製備5-溴-1,3,4-㗁二唑-2-羧酸乙基酯(E42)
在0℃下，向5-胺基-1,3,4-㗁二唑-2-羧酸乙基酯(5 g, 31.8 mmol)在MeCN (60 mL)中之溶液中，添加CuBr 2(10.66 g, 47.7 mmol, 2.2 mL, 1.5 eq)。反應混合物轉變為深綠色，且在室溫下攪拌15分鐘。在0℃下，添加t-BuONO (4.92 g, 47.7 mmol, 5.7 mL, 1.5 eq)，且將反應混合物在室溫下攪拌2小時，接著在50℃下加熱另外12小時。使用TLC (PE/EtOAc=1/1)檢查反應進程。將反應混合物過濾並濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至50% EtOAc/PE，梯度在40 mL/min下）純化，以得到E42（4.5 g，64%產率）。 1H NMR (400 MHz, CDCl 3) δ 4.52 (q, 2 H), 1.45 (t, 3 H)。 步驟2：製備5- 啉-1,3,4-㗁二唑-2-羧酸乙基酯(E43)
在0℃下，向5-溴-1,3,4-㗁二唑-2-羧酸乙基酯(E42) (1 g, 4.52 mmol)及 啉(473 mg, 5.43 mmol, 478 µL, 1.2 eq)在THF (40 mL)中之溶液中，添加DIPEA (1.17 g, 9.05 mmol, 1.6 mL, 2 eq)。在室溫下將混合物攪拌1小時。使用TLC (PE/EtOAc=1/1)檢查反應進程。將EtOAc (100 mL)添加至反應混合物中，且將有機部分用水(30 mL)及鹽水(30 mL × 2)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；12 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至30% EtOAc/PE，梯度在35 mL/min下）純化，以得到E43（800 mg，78%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 4.37 (q, 2 H), 3.68-3.74 (m, 4 H), 3.48-3.52 (m, 4 H), 1.31 (t, 3 H)。 步驟3：製備(5- 啉-1,3,4-㗁二唑-2-羰基)氧鋰(E44)
向5- 啉-1, 3, 4-㗁二唑-2-羧酸乙基酯(E43) (800 mg, 3.52 mmol)在THF (8 mL)及H 2O (12 mL)中之溶液中，添加LiOH.H 2O (162 mg, 3.87 mmol, 1.1 eq)。將反應混合物在室溫下攪拌12小時。使用TLC (PE:EtOAc=1:1)檢查反應進程。將反應混合物濃縮至乾燥，以得到E44 (600 mg)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 3.62-3.74 (m, 4 H), 3.36 (br d, 4 H)。
根據一般方案9方法A之中間物[5-(5-氟-2-吡啶基)-1,3,4-㗁二唑-2-羰基]氧鋰 步驟1：製備5-氟吡啶-2-羧酸甲基酯(E45)
將5-氟吡啶-2-甲腈(15 g, 123 mmol)在HCl/MeOH (4 M, 180 mL, 5.9 eq)中之溶液在60℃下攪拌12小時。將反應混合物真空濃縮，且將殘餘物溶解在EtOAc (150 mL)中，用飽和NaHCO 3溶液(50 mL)及鹽水(20 mL)洗滌。將有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至25% EtOAc/PE，梯度在60 mL/min下）純化，以得到E45（15.24 g，80%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.58 (d, 1 H), 8.20 (dd, 1 H), 7.53 (ddd, 1 H), 4.00 (s, 3 H)。 步驟2：製備5-氟吡啶-2-碳醯肼(E46)
將5-氟吡啶-2-羧酸甲基酯(E45) (16 g, 103 mmol)、NH 2NH 2.H 2O（11.06 g，217 mmol，10.7 mL，98%純度，2.1eq）在EtOH (70 mL)中之混合物除氣且用N 2吹掃3次，且接著將反應混合物在室溫下在N 2氣氛下攪拌3小時。將反應混合物濃縮至乾燥，以得到E46（15 g，94%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 9.89 (br s, 1 H), 8.61 (d, 1 H), 8.07 (dd, 1 H), 7.88 (td, 1 H), 4.57 (br s, 2 H)。 步驟3：製備2-[2-(5-氟吡啶-2-羰基)肼基]-2-側氧基-乙酸乙基酯(E47)
在0℃下歷經10分鐘之時間段，向5-氟吡啶-2-碳醯肼(E46) (13.5 g, 87.0 mmol)及TEA (17.61 g, 174 mmol, 24.2 mL, 2 eq)在DCM (500 mL)中之混合物中，添加2-氯-2-側氧基-乙酸乙基酯(15.45 g, 113 mmol, 12.7 mL, 1.3 eq)。將反應混合在室溫下攪拌2小時。將H 2O (100 mL)添加至反應混合物中，且將水性部分用DCM (300 mL×3)萃取。將合併之有機層用鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至2.5% EtOAc/PE，梯度在60 mL/min下）純化，以得到E47（16 g，53%產率）。 1H NMR (400 MHz, CDCl 3) δ 10.03-10.15 (m, 1 H), 9.65 (br d, 1 H), 8.35-8.42 (m, 1 H), 8.11-8.18 (m, 1 H), 7.51 (td, 2 H), 4.35 (q, 1 H), 1.34 (t, 3 H)；LCMS: m/z 256.2 [M+H] +。 步驟4：製備5-(5-氟-2-吡啶基)-1,3,4-㗁二唑-2-羧酸乙基酯(E48)
在0℃下，向2-[2-(5-氟吡啶-2-羰基)肼基]-2-側氧基-乙酸乙基酯(E47) (16 g, 62.7 mmol)在DCM (350 mL)中之溶液中，分3批添加TEA (8.25 g, 81.5 mmol, 11.3 mL, 1.3 eq)及TosCl (5.98 g, 31.4 mmol, 0.5 eq)。在室溫下將混合物攪拌3小時。添加飽和NaHCO 3溶液(200 mL)，且將水性部分用DCM (400 mL×3)萃取。將合併之有機層用鹽水(200 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；120 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至2.5% MeOH/DCM，在85 mL/min下）純化，以得到E48（8.2 g，49%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.71 (d, 1 H), 8.39 (dd, 1 H), 7.66 (ddd, 1 H), 4.59 (q, 2 H), 1.51 (t, 3 H)；LCMS: m/z 238.2 [M+H] +。 步驟5：製備[5-(5-氟-2-吡啶基)-1,3,4-㗁二唑-2-羰基]氧鋰(E49)
向5-(5-氟-2-吡啶基)-1,3,4-㗁二唑-2-羧酸乙基酯(E48) (12 g, 50.6 mmol)在THF (140 mL)及H 2O (180 mL)中之溶液中，添加LiOH.H 2O (2.23 g, 53.1 mmol, 1.05 eq)。將混合物在室溫下攪拌2小時。將反應混合物真空濃縮以移除大部分THF，且將水性部分真空凍乾，以得到E49 (11.5 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.79 (d, 1 H), 8.24 (dd, 1 H), 7.99 (td, 1 H)。 中間物5-(二氟甲基)-1-(2,2,2-三氟乙基)吡唑-4-羧酸 步驟1：製備5-(二氟甲基)-1-(2,2,2-三氟乙基)吡唑-4-羧酸乙基酯(E50)
在0℃下，向(Z)-乙基2-(乙氧基亞甲基)-4,4-二氟-3-側氧基丁酸酯(1 g, 4.52 mmol)在THF (8 mL)中之溶液中，逐滴添加2,2,2-三氟乙基肼(670 mg, 5.88 mmol, 1.3 eq)。將反應混合物在0℃下攪拌1小時且接著在室溫下攪拌16小時。使用LCMS檢查反應進程。將反應混合物濃縮至乾燥，且將殘餘物藉由快速矽膠層析（洗提液：0%至5% EtOAc/PE梯度）純化，以得到E50（850 mg，69%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.02 (s, 1 H), 7.38-7.75 (m, 1 H), 4.95 (q, 2 H), 4.37 (q, 2 H), 1.40 (t, 3 H)；LCMS: m/z 273.1 [M+H] +。 步驟2：製備5-(二氟甲基)-1-(2,2,2-三氟乙基)吡唑-4-羧酸(E51)
向5-(二氟甲基)-1-(2,2,2-三氟乙基)吡唑-4-羧酸乙基酯(E50) (910 mg, 3.34 mmol)在THF (5 mL)及H 2O (5 mL)中之溶液中，添加LiOH.H 2O (224 mg, 5.35 mmol, 1.6 eq)。將混合物在室溫下攪拌2小時。使用TLC (PE:EtOAc=2:1)檢查反應進程。將反應混合物濃縮以移除THF。接著藉由添加HCl (1 M)將水性部分調節至pH為約6。將所得沉澱物藉由過濾進行收集且隨後真空乾燥，以得到E51（816 mg，100%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.08 (s, 1 H), 7.45-7.78 (m, 1 H), 5.30 (q, 2 H)。 中間物2-(2-吡啶基)吡唑-3-羧酸乙基酯 步驟1：製備(E)-4-(二甲胺基)-2-側氧基-丁-3-烯酸乙基酯(E52)
將2-側氧基丙酸乙基酯(2 g, 17.2 mmol, 1.9 mL)及1,1-二甲氧基-N,N-二甲基-甲胺(2.09 g, 17.6 mmol, 2.3 mL, 1.02 eq)在室溫下攪拌12小時。使用TLC (PE:EtOAc=10:1)檢查反應進程。將反應混合物濃縮至乾燥，以得到E52 (2.4 g)，其未經進一步純化即被使用。 步驟2：製備2-(2-吡啶基)吡唑-3-羧酸乙基酯(E53)
將(E)-4-(二甲胺基)-2-側氧基-丁-3-烯酸乙基酯(E52) (2.4 g, 14.0 mmol)及2-吡啶基肼(1.53 g, 14.0 mmol)在HOAc (100 mL)中之混合物在110℃下攪拌12小時。使用TLC (PE:EtOAc=10:1)檢查反應進程。將反應混合物藉由添加飽和Na 2CO 3溶液而調節至pH為約9。將水性部分用EtOAc (300 mL)萃取。將有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由矽膠管柱層析（SiO 2，PE/EtOAc=100/1至50/1）純化，以得到E53（1.03 g，34%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.48 (dt, 1 H), 8.05 (td, 1 H), 7.83-7.96 (m, 1 H), 7.76 (d, 1 H), 7.49 (ddd, 1 H), 6.96-7.05 (m, 1 H), 4.21 (q, 2 H), 1.05-1.23 (m, 3 H)；LCMS: m/z 218.1 [M+H] +。
亦獲得1-(2-吡啶基)吡唑-3-羧酸乙基酯(E53a)（190 mg，6%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.70-8.81 (m, 1 H), 8.54 (dd, 1 H), 7.92-8.13 (m, 2 H), 7.47 (ddd, 1 H), 7.02 (d, 1 H), 4.35 (q, 2 H), 1.34 (t, 3 H)。E53及E53a之區域化學藉由HSQC及HMBC NMR分析得到確認。 步驟3：製備2-(2-吡啶基)吡唑-3-羧酸(E54)
向2-(2-吡啶基)吡唑-3-羧酸乙基酯(E53) (1 g, 4.60 mmol)在THF (10 mL)及H 2O (10 mL)中之溶液中，添加LiOH.H 2O (386 mg, 9.21 mmol, 2eq)，且將反應混合物在室溫下攪拌12小時。使用TLC (PE/EtOAc=1/1)檢查反應進程。將反應混合物在減壓下濃縮以移除THF。將水性部分藉由添加2 M HCl調節至pH為約7，且真空凍乾，以得到(E54) (1.2 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 8.36-8.44 (m, 1 H), 7.88 (td, 1 H), 7.44-7.53 (m, 2 H), 7.35 (ddd, 1 H), 6.44 (d, 1 H)。 中間物[5-(二氟甲基)-2-甲基-1,2,4-三唑-3-羰基]氧鋰 步驟1：製備(Z)-2-(1-胺基-2-乙氧基-2-側氧基亞乙基)肼-1-甲酸三級丁基酯(E55)
(Z)-2-(1-胺基-2-乙氧基-2-側氧基亞乙基)肼-1-羧酸三級丁基酯係由2-胺基-2-硫酮基乙酸乙基酯按照Bioorg. Med. Chem., 26 (2016) 3223-3225中之程序製備。將反應加熱至回流。 步驟2：製備3-(二氟甲基)-1H-1,2,4-三唑-5-羧酸乙基酯(E56)
藉由在0℃下將草醯二氯(18.90 g, 149 mmol, 13.0 mL, 1.1 eq)逐滴添加2,2-二氟乙酸(13 g, 135 mmol, 8.5 mL)及DMF (989 mg, 13.5 mmol, 1.0 mL, 0.1 eq)在DCM (80 mL)中之溶液中來製備試劑2,2-二氟乙醯氯。將反應混合物在室溫下攪拌1小時，且溶液未經進一步純化即被使用。
向(Z)-2-(1-胺基-2-乙氧基-2-側氧基亞乙基)肼-1-羧酸三級丁基酯(E55) (13 g, 56.2 mmol)在吡啶(90 mL)中之溶液中，添加2,2-二氟乙醯氯(15.47 g, 135 mmol, 2.4 eq)。將反應混合物加熱至120℃並攪拌12小時。使用LCMS檢查反應進程。將反應混合物濃縮至乾燥。將DCM (200 mL)添加至殘餘物中，且將有機部分用1 MHCl (30 mL)及鹽水(60 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由矽膠管柱層析（PE:EtOAc=20:1至2:1）純化，以得到E56（8.87 g，83%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 7.01-7.32 (m, 1 H), 4.36 (q, 2 H), 1.30 (t, 3 H)；LCMS: m/z 192.0 [M+H] +。 步驟3：製備5-(二氟甲基)-2-甲基-1,2,4-三唑-3-羧酸乙基酯(E57)
向3-(二氟甲基)-1H-1,2,4-三唑-5-羧酸乙基酯(E56) (10 g, 52.3 mmol)在DMF (80 mL)中之溶液中，添加MeI (22.28 g, 157 mmol, 9.8 mL, 3 eq)及K 2CO 3(21.69 g, 157 mmol, 3 eq)。將混合物在室溫下攪拌12小時。使用TLC (PE:EtOAc=1:1)檢查反應進程。將反應混合物進行過濾，且將沉澱物用EtOAc (150 mL)沖洗。將濾液用水(30 mL)及鹽水(30 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由矽膠管柱層析（PE:EtOAc=20:1至1:1）純化，以得到E57（4.46 g，42%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 6.99-7.34 (m, 1 H), 4.39 (q, 2 H), 4.11-4.22 (m, 3 H), 1.35 (t, 3 H)。 步驟4：製備[5-(二氟甲基)-2-甲基-1,2,4-三唑-3-羰基]氧鋰(E58)
向5-(二氟甲基)-2-甲基-1,2,4-三唑-3-羧酸乙基酯(E57) (2.35 g, 11.5 mmol)在THF (40 mL)及H 2O (10 mL)中之溶液中，添加LiOH.H 2O (505 mg, 12.0 mmol, 1.05 eq)。在室溫下將反應混合物攪拌1小時。使用TLC (PE:EtOAc=2:1)檢查反應進程。將反應混合物真空濃縮以移除THF。添加H 2O (20 mL)，且將水性部分用TBME (20 mL)萃取，且隨後真空凍乾，以得到E58 (2.15 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 6.75-7.21 (m, 1 H), 4.09 (s, 3 H)。 中間物3-(1-羥基-1-甲基-乙基)-1,2,4-㗁二唑-5-羧酸乙基酯 步驟1：製備N',2-二羥基-2-甲基-丙脒(E59)
向2-羥基-2-甲基-丙腈(2.14 g, 25.2 mmol, 2.3 mL)在EtOH (20 mL)中之溶液中，添加羥基胺基鹽酸鹽(3.49 g, 50.3 mmol, 2 eq)及Na 2CO 3(5.33 g, 50.3 mmol, 2 eq)，且接著在70℃下將反應攪拌16小時。將反應混合物濃縮至乾燥。將EtOAc (200 mL)添加至殘餘物中，且將有機部分用水(50 mL)及鹽水(50 mL)洗滌兩次，經Na 2SO 4乾燥、過濾且濃縮至乾燥以得到E59 (1 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, DMSO- d 6) δ 10.11 (s, 1 H), 8.86 (s, 1 H), 5.03 (br s, 1 H), 1.70 (s, 3 H), 1.66 (s, 3 H)。 步驟2：製備3-(1-羥基-1-甲基-乙基)-1,2,4-㗁二唑-5-羧酸乙基酯(E60)
在0℃下，向N',2-二羥基-2-甲基-丙脒(E59) (520 mg, 4.40 mmol)及吡啶(696 mg, 8.80 mmol, 711 µL, 2 eq)在甲苯(15 mL)中之溶液中，添加2-氯-2-側氧基-乙酸乙基酯(601 mg, 4.40 mmol, 493 µL)。將反應混合物在室溫下攪拌1小時且接著在100℃下攪拌15小時。使用LCMS檢查反應進程。將反應混合物濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至2/1）純化，且藉由製備型HPLC（管柱：Boston Uni C18 40*150*5um；移動相：[水(0.225%FA)-ACN]；B%：16%至46%，7.7分鐘）進一步純化，以得到E60（250 mg，28%產率）。 1H NMR (400 MHz, CDCl 3) δ 4.52 (q, 2 H), 2.65 (br s, 1 H), 1.67 (s, 6 H), 1.45 (t, 3 H)；LCMS: m/z 201.1 [M+H] +。 步驟3：製備3-(1-羥基-1-甲基-乙基)-1,2,4-㗁二唑-5-羧酸乙基酯(E61)
向3-(1-羥基-1-甲基-乙基)-1,2,4-㗁二唑-5-羧酸乙基酯(E60) (200 mg, 999 µmol)在THF (5 mL)及H 2O (5 mL)中之溶液中，添加LiOH.H 2O (41.9 mg, 999 µmol)，且接著在室溫下將反應混合物攪拌1小時。將溶液真空移除，且將水性部分真空凍乾，以得到E61 (170 mg)，其未經進一步純化即被使用。 中間物E62、E63、E64、E65、E66、及E67 步驟A：製備6-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E62)及6-溴-7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E63)
在-78℃下，向6-溴吡唑并[1,5-a]吡啶-3-羧酸甲基酯(1 g, 3.92 mmol)在THF (10 mL)中之溶液中，添加i-PrMgCl-LiCl (1.3 M, 6.03 mL, 2 eq)。將反應混合物在-78℃下攪拌15分鐘，然後將丙酮(1.37 g, 23.5 mmol, 1.7 mL, 6 eq)逐滴添加至反應混合物中。在-78℃下將反應混合物攪拌1小時。使用LCMS檢查反應進程。將反應混合物逐滴添加至10 mLNH 4Cl水溶液中。添加水(30 mL)，且將水性部分用EtOAc (25 mL×2)萃取。將合併之有機層用鹽水(20 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1:0至20:1）純化，以得到E62（320 mg，34%產率）及E63（300 mg，23%產率）。
E62： 1H NMR (400 MHz, CD 3OD) δ 8.40-8.54 (m, 1 H), 8.14 (dd, 1 H), 7.57 (dd, 1 H), 7.27 (dd, 1 H), 3.88-4.03 (m, 3 H), 1.77-1.92 (m, 6 H)；LCMS: m/z 235.2 [M+H] +。
E63： 1H NMR (400 MHz, CD 3OD) δ 8.46 (s, 1 H), 8.02 (d, 1 H), 7.76 (d, 1 H), 3.93 (s, 3 H), 1.95 (s, 6 H)；LCMS: m/z 313.0 [M+H] +。 步驟B：製備6-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸(E64)
向6-(1-羥基-1-甲基-乙基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E62) (500 mg, 2.13 mmol)在MeOH (3 mL)及H 2O (1 mL)中之溶液中，添加LiOH.H 2O (116 mg, 2.77 mmol, 1.3 eq)。將反應混合物在40℃下攪拌12小時。使用LCMS檢查反應進程。將反應混合物真空濃縮以移除MeOH，且添加水(50 mL)。將水性部分用TBME (30 mL)萃取，且將水層藉由添加0.5 MHCl而調節至pH為約6。將所得懸浮液用DCM/MeOH (100/10 mL)萃取3次。將合併之DCM/MeOH有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到E64（420 mg，89%產率）。LCMS: m/z 221.1 [M+H] +。 步驟C：製備6-溴-7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸(E65)
向6-溴-7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E63) (120 mg, 383 µmol)在MeOH (2 mL)及H 2O (1 mL)中之溶液中，添加LiOH.H 2O (17.69 mg, 422 µmol, 1.1 eq)，且將混合物在40℃下攪拌12小時。使用LCMS檢查反應進程。將反應混合物真空濃縮以移除MeOH，且添加水(10 mL)。將水性部分用TBME (30 mL)萃取且隨後藉由添加0.5 MHCl而調節至pH為約6。將所得懸浮液用DCM/MeOH (30/3 mL)萃取3次。將合併之DCM/MeOH有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到E65（100 mg，87%產率）。 1H NMR (400 MHz, CD 3OD) δ 8.44 (s, 1 H), 8.07 (d, 1 H), 7.74 (d, 1 H), 1.96 (s, 6 H)；LCMS: m/z 301.1 [M+H] +。 步驟D：製備7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E66)
在N 2下，向6-溴-7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E63) (450 mg, 1.44 mmol)在MeOH (10 mL)中之溶液中，添加Pd/C（100 mg，10%純度）。將所得混合物真空除氣且用H 2吹掃3次，且隨後將混合物在室溫下在H 2(15 psi)下攪拌1小時。使用LCMS檢查反應進程。將反應混合物經由矽藻土墊過濾，且將濾液真空濃縮，以得到E66 (350 mg)，其未經進一步純化即被使用。LCMS: m/z 234.9 [M+H] +。 步驟E：製備7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸(E67)
向7-(2-羥基丙-2-基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E66) (350 mg, 1.49 mmol)在MeOH (5 mL)及H 2O (1 mL)中之溶液中，添加NaOH (89.64 mg, 2.24 mmol, 1.5 eq)，將混合物在40℃下攪拌12小時。使用LCMS檢查反應進程。將反應混合物真空濃縮以移除MeOH，且添加水(10 mL)。將水性部分用TBME (30 mL)萃取且隨後藉由添加0.5 MHCl而調節至pH為約6。將所得懸浮液用DCM/MeOH (30/3 mL)萃取3次。將合併之DCM/MeOH有機層經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到E67 (320 mg)，其未經進一步純化即被使用。LCMS: m/z 220.9 [M+H] +。
根據一般方案7方法C及D之中間物E72 步驟A：製備6-乙烯基吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E68)
將4,4,5,5-四甲基-2-乙烯基-1,3,2-二氧雜硼雜環戊烷(8.15 g, 52.9 mmol, 8.98 mL)、6-溴吡唑并[1,5-a]吡啶-3-羧酸甲基酯(9 g, 35.3 mmol)、K 3PO 4(22.47 g, 106 mmol)及Pd(dppf)Cl 2(1.29 g, 1.76 mmol)在二㗁烷(80 mL)及H 2O (40 mL)中之混合物在80℃下在N 2下攪拌12小時。使用LCMS檢查反應進程。將反應混合物與另一1 g批次反應合併，且添加DCM (200 mL)。將有機層用鹽水(2 ×80 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至4/1）純化，以得到E68（6.4 g，80.2%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.37 (s, 1 H), 8.30 (s, 1 H), 8.03 (d, 1 H), 7.52 (dd, 1 H), 6.61 (dd, 1 H), 5.76 (d, 1 H), 5.34 (d, 1 H), 3.84 (s, 3 H)；LCMS: m/z 203.1 [M+H] +。 步驟B：製備6-甲醯基吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E69)
在0℃下，向6-乙烯基吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E68) (6.4 g, 31.7 mmol)在THF (80 mL)及H 2O (80 mL)之溶液中，添加K 2OsO 4.2H 2O (583 mg, 1.58 mmol)及NaIO 4(16.92 g, 79.1 mmol, 4.38 mL)，且接著將反應混合物在室溫下攪拌12小時。使用LCMS檢查反應進程。將DCM (200 mL)添加至反應混合物中，且將有機層用鹽水(2 × 80 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，DCM/EtOAc=1/0至6/1）純化，以得到E69（5.9 g，91.3%產率）。 1H NMR (400 MHz, CDCl 3) δ 9.94 (s, 1 H), 8.90-8.98 (m, 1 H), 8.48 (s, 1 H), 8.18 (d, 1 H), 7.80 (dd, 1 H), 3.88 (s, 3 H)；LCMS: m/z 204.9 [M+H] +。 步驟C：製備6-(羥基甲基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E70)
在0℃下，向6-甲醯基吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E69) (2.4 g, 11.8 mmol)在THF (30 mL)及MeOH (30 mL)中之溶液中，添加NaBH 4(1.78 g, 47.0 mmol)，且接著將反應混合物在室溫下攪拌1小時。使用LCMS檢查反應進程。將反應混合物藉由添加飽和NH 4Cl (50 mL)來淬滅，且將水性部分用EtOAc (100 mL)萃取。將有機層用水(50 mL)及鹽水(40 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥，以得到E70（2.3 g，94.9%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.54 (s, 1 H), 8.38 (s, 1 H), 8.11 (d, 1 H), 7.41 (dd, 1 H), 4.78 (s, 2 H), 3.93 (s, 3 H)；LCMS: m/z 207.0 [M+H] +。 步驟D：製備6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E71)
在0℃下，向6-(羥基甲基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E70) (2.2 g, 10.7 mmol)在THF (50 mL)中之溶液中，添加NaH（512 mg，12.8 mmol，60%純度）。將反應混合物在0℃下攪拌15分鐘，然後將MeI (1.82 g, 12.8 mmol, 797 µL)添加至反應混合物中。將反應混合物在室溫下攪拌1小時，且使用LCMS檢查反應進程。將反應混合物藉由添加飽和NH 4Cl (40 mL)淬滅，且將水性部分用DCM (2 × 60 mL)萃取。將合併之有機層藉由水(30 mL)及鹽水(30 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至5/1）純化，以得到E71（1.8 g，76.6%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.52 (s, 1 H), 8.41 (s, 1 H), 8.16 (d, 1 H), 7.42 (dd, 1 H), 4.53 (s, 2 H), 3.94 (s, 3 H), 3.46 (s, 3 H)；LCMS: m/z 221.1 [M+H] +。 步驟E：製備6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羧酸(E72)
向6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羧酸甲基酯(E71) (1.8 g, 8.17 mmol)在MeOH (40 mL)及H 2O (40 mL)中之溶液中，添加NaOH (719 mg, 18.0 mmol)，且將反應混合物在40℃下攪拌12小時。使用LCMS檢查反應進程。將反應混合物濃縮以移除MeOH，且接著添加H 2O (10 mL)。藉由添加0.5 M HCl，將水性混合物之pH調節至約6，且將水性混合物進行過濾。將沉澱物真空乾燥，以得到E72（1.6 g，94.9%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.57 (s, 1 H), 8.45-8.51 (m, 1 H), 8.21 (d, 1 H), 7.48 (dd, 1 H), 4.55 (s, 2 H), 3.48 (s, 3 H)；LCMS: m/z 206.7 [M+H] +。
根據一般方案9方法A之中間物E78 步驟A：製備2,6-二氟苯甲醯肼(E73)
向2,6-二氟苯甲酸甲基酯(25 g, 145 mmol)在MeOH (250 mL)中之溶液中，添加NH 2NH 2.H 2O (18.18 g, 363 mmol, 17.7 mL)，且將反應混合物在60℃下攪拌12小時。使用TLC檢查反應進程。添加額外的NH 2NH 2.H 2O (7.27 g, 145 mmol, 7.05 mL)，且將反應混合物在60℃下再攪拌3小時。將反應混合物真空濃縮，以得到E73 (25 g)，其未經進一步純化即被使用。 1H NMR (400 MHz, CDCl 3) δ 7.37 (s, 1 H), 6.93 (t, 2 H), 3.45-3.89 (m, 2 H)。 步驟B：製備2-[2-(2,6-二氟苯甲醯基)肼基]-2-側氧基-乙酸甲基酯(E74)
在0℃下，向2,6-二氟苯甲醯肼(E73) (25 g, 145 mmol)在THF (250 mL)中之溶液中，添加2-氯-2-側氧基-乙酸甲基酯(19.57 g, 160 mmol, 14.7 mL)，且將反應混合物在0℃下攪拌1小時。使用TLC檢查反應進程。將反應混合物進行過濾。將沉澱物用MTBE (800 mL)洗滌，且然後真空乾燥，以得到E74 (37 g)。 1H NMR (400 MHz, DMSO- d 6) δ 7.59 (ddd, 2 H), 7.21 (t, 1 H), 3.83 (s, 2 H)。 步驟C：製備5-(2,6-二氟苯基)-1,3,4-㗁二唑-2-羧酸甲基酯(E75)
在0℃下，向2-[2-(2,6-二氟苯甲醯基)肼基]-2-側氧基-乙酸甲基酯(E74) (15 g, 58.1 mmol)在DCM (250 mL)中之溶液中，分批添加Et 3N (23.52 g, 232 mmol, 32.4 mL)及TosCl (14.40 g, 75.5 mmol)。將反應混合物溫熱至室溫並在室溫下攪拌12小時。使用TLC檢查反應進程。將DCM (100 mL)添加至反應混合物中，且將有機層用飽和NaHCO 3水溶液(100 mL)及水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至1/1）純化，以得到E75（4.3 g，30.8%產率）。 1H NMR (400 MHz, CDCl 3) δ 7.61 (tt, 1 H), 7.14 (t, 2 H), 4.10 (s, 3 H)。 步驟D：製備5-(2,6-二氟苯基)-1,3,4-㗁二唑-2-羧酸(E76)
向5-(2,6-二氟苯基)-1,3,4-㗁二唑-2-羧酸甲基酯(E75) (300 mg, 1.25 mmol)在H 2O (2 mL)及THF (4 mL)中之溶液中，添加LiOH.H 2O (52.4 mg, 1.25 mmol)。在室溫下將反應混合物攪拌1小時。使用LCMS檢查反應進程。將反應混合物真空濃縮，以得到E76 (300 mg)，其未經進一步純化即被使用。LCMS: m/z 226.8 [M+H] +步驟E：製備2-(2,6-二氟苯基)-1,3,4-㗁二唑(E77)
向5-(2,6-二氟苯基)-1,3,4-㗁二唑-2-羧酸(E76) (4 g, 17.7 mmol)之在H 2O (20 mL)中之溶液中，添加HCl (1 M, 35.4 mL)，且將反應混合物在室溫下攪拌1小時。使用LCMS及TLC檢查反應進程。將DCM (60 mL)添加至反應混合物中，且將有機層用水(20 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至1/1）純化，以得到E77（1.5 g，46.6%產率）。 1H NMR (400 MHz, CDCl 3) δ 8.63 (s, 1 H), 7.57 (tt, 1 H), 7.12 (t, 2 H)；LCMS: m/z 182.8 [M+H] +。 步驟F：製備2-溴-5-(2,6-二氟苯基)-1,3,4-㗁二唑(E78)
在-78℃下，向2-(2,6-二氟苯基)-1,3,4-㗁二唑(E77) (1.5 g, 8.24 mmol)在THF (50 mL)中之溶液中，逐滴添加LiHMDS (1 M, 16.5 mL)。將反應混合物在-78℃下攪拌30分鐘，接著將Br 2(2.63 g, 16.5 mmol, 849 µL)在-78℃下逐滴添加至反應混合物中。將反應混合物在-78℃下攪拌2小時。使用TLC檢查反應進程。將飽和NH 4Cl水溶液(100 mL)添加至反應混合物中，且將水性部分用DCM (3 × 50 mL)萃取。將合併之有機層用鹽水(40 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由管柱層析（SiO 2，PE/EtOAc=1/0至3/1）純化，以得到E78（1.6 g，54.2%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 7.79 (tt, 1 H), 7.41 (t, 2 H)；LCMS: m/z 341.2 [M+H] +。
根據一般方案1方法C製備實例640及641 步驟1：製備4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
將吡唑并[1,5-a]吡啶-2-甲醛(C3) (9.2 g, 63.0 mmol)、2-(1H-咪唑-5-基)乙胺（15.06 g，81.8 mmol，1.3 eq，2HCl鹽）及K 2CO 3(17.40 g, 126 mmol, 2 eq)在EtOH (300 mL)中之混合物在N 2下在80℃下攪拌16小時。使用LCMS檢查反應進程。將反應混合物與使用5 g C3進行之另一反應混合物合併並過濾，且將濾液濃縮至乾燥。將殘餘物藉由矽膠管柱層析（DCM:MeOH =20:1至10:1）純化，以得到4-吡唑并[1,5-a]吡啶-2-基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(11.4 g)。 1H NMR (400 MHz, CD 3OD) δ 8.48 (d, 1 H), 7.54-7.62 (m, 2 H), 7.09-7.29 (m, 1 H), 6.82-6.90 (m, 1 H), 6.44 (s, 1 H), 5.28 (s, 1 H), 3.28 (dt, 1 H), 3.04-3.12 (m, 1 H), 2.73-2.80 (m, 2 H)；LC‑MS：m/z 240.2 (M+H) +。 步驟2：製備5-(4-吡唑并[1,5-a]吡啶-2-基-1,4,6,7-四氫咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈
向4-吡唑并[1,5-a]吡啶-2-基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(4 g, 16.7 mmol)及(4-氰基㗁唑-5-羰基)氧鋰(E35) (3.37 g, 23.4 mmol, 1.4 eq)在DMF (90 mL)中之溶液中，添加HATU (7.63 g, 20.1 mmol, 1.2 eq)及吡啶(3.97 g, 50.2 mmol, 4.1 mL, 3 eq)。將反應混合物在室溫下攪拌2小時。使用LCMS檢查反應進程，且將反應混合物在室溫下再攪拌12小時。使用TLC (DCM:MeOH =10:1)檢查反應進程。添加DCM (300 mL)，且將有機部分用飽和NaHCO 3溶液(100 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；40 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至8.5% MeOH/DCM，在35 mL/min下）純化，以得到5-(4-吡唑并[1,5-a]吡啶-2-基-1,4,6,7-四氫咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈(2.6 g)。 1H NMR (400 MHz, CD 3OD) δ 8.51 (s, 1 H), 8.46 (d, 1 H), 7.69 (s, 1 H), 7.57-7.65 (m, 1 H), 7.17-7.23 (m, 1 H), 6.83-6.91 (m, 2 H), 6.59-6.72 (m, 1 H), 4.40 (br d, 1 H), 3.77 (br d, 1 H), 3.19 (s, 1 H), 2.85 (br s, 1 H)；LC‑MS：m/z 360.2 (M+H) +。 步驟3：SFC分離
將5-(4-吡唑并[1,5-a]吡啶-2-基-1,4,6,7-四氫咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈(2.6 g)藉由SFC（管柱：DAICEL CHIRALPAK AD(250 mm*50 mm, 10um)；移動相：[Neu-ETOH]；B%：45%至45%，min）分離，以得到鏡像異構物1 (650 mg, Rt=1.884 min)及鏡像異構物2 (450 mg, Rt=2.124 min)。
鏡像異構物1（實例640）：(S)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈。 1H NMR (400 MHz, CD 3OD) δ 8.52 (s, 1 H), 8.46 (dd, 1 H), 7.71 (s, 1 H), 7.62 (br d, 1 H), 7.17-7.26 (m, 1 H), 6.85-6.92 (m, 1.7 H), 6.48-6.69 (m, 1.3 H), 4.77-4.87 (m, 0.4 H), 4.40 (br d, 0.6 H), 3.79 (br s, 1 H), 3.10-3.19 (m, 1 H), 2.79-2.91 (m, 1 H)；LC‑MS：m/z 360.1 (M+H) +；SFC: 94.1% ee。
鏡像異構物2（實例641）：(R)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶-5-羰基)㗁唑-4-甲腈。 1H NMR (400 MHz, CD 3OD) δ 8.51 (s, 1 H), 8.46 (dd, 1 H), 7.71 (s, 1 H), 7.62 (br d, 1 H), 7.13-7.26 (m, 1 H), 6.84-6.94 (m, 1.7 H), 6.49-6.70 (m, 1.3 H), 4.77-4.87 (m, 0.4 H), 4.40 (br d, 0.6 H), 3.71-3.91 (m, 1 H), 3.08-3.19 (m, 1 H), 2.79-2.89 (m, 1 H)；LC‑MS：m/z 360.2 (M+H) +；SFC：96.7% ee。
根據一般方案1方法C製備實例836及837 步驟1：製備(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮
在室溫下，向4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(150 mg, 488 µmol)及5-(1-甲基吡唑-3-基)-1,3,4-㗁二唑-2-羧酸（根據一般方案9方法A以1-甲基-1H-吡唑-3-羧酸甲基酯開始進行製備）(142 mg, 732 µmol)在DMSO (3 mL)中之溶液中，添加吡啶(116 mg, 1.46 mmol, 118 µL)及HATU (241 mg, 635 µmol)。將反應混合物在室溫下攪拌16小時。使用LCMS檢查反應進程。將反應混合物提交至製備型HPLC（管柱：Welch Xtimate C18 150*30 mm*5um；移動相：[水(0.05%NH 3H 2O+10 mM NH 4HCO 3)-ACN]；B%：27%至57%，9min），以得到(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮。（100 mg，42.4%產率）。LCMS: m/z 484.1 [M+H] +。 步驟2：SFC分離
將化合物(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮(100 mg, 207 µmol)藉由SFC（管柱：Phenomenex-Cellulose-2 (250 mm*50 mm,10um)；移動相：[0.1%NH 3H 2O EtOH]；B%：50%至50%，min）分離，以得到鏡像異構物1（46.1 mg，46.1%產率，Rt=5.268 min）及鏡像異構物2（46.2 mg，45.6%產率，Rt=10.218 min）。
鏡像異構物1（實例836）：(S)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮。 1H NMR (400 MHz, CD 3OD) δ 8.59-8.76 (m, 1 H), 7.81 (d, 1 H), 7.74 (s, 1 H), 7.53-7.66 (m, 1 H), 6.86-7.12 (m, 3 H), 6.76-6.84 (m, 1 H), 5.08 (br dd, 1 H), 4.03 (s, 3 H), 3.72-3.84 (m, 0.6 H), 3.41 (td, 0.4 H), 3.13-3.27 (m, 0.6 H), 2.95-3.09 (m, 0.4 H), 2.77-2.94 (m, 1 H)；LCMS: m/z 484.2 [M+H] +；SFC: 100% ee。
鏡像異構物2（實例837）：(R)-(5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑-2-基)(4-(4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)甲酮。 1H NMR (400 MHz, CD 3OD) δ 8.42-8.69 (m, 1 H), 7.60-7.79 (m, 2 H), 7.41-7.57 (m, 1 H), 6.80-6.97 (m, 3 H), 6.60-6.75 (m, 1 H), 4.96 (br dd, 1 H), 3.92 (s, 3 H), 3.60-3.73 (m, 0.5 H), 3.24-3.37 (m, 0.5 H), 3.03-3.17 (m, 0.5 H), 2.84-3.00 (m, 0.5 H), 2.68-2.80 (m, 1 H)；LCMS: m/z 484.2 [M+H] +；SFC: 98.7% ee。
根據一般方案1方法C製備實例1628及1629 步驟1：製備(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮
向6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羧酸(E72) (144 mg, 700 µmol)及4-(4-氟吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(150 mg, 583 µmol)在DMF (3 mL)中之溶液中，添加HATU (333 mg, 875 µmol)及Py (185 mg, 2.33 mmol, 188.2 µL)，且將反應混合物在室溫下攪拌12小時。使用LCMS檢查反應進程。將DCM (30 mL)添加至反應混合物中，且將有機層用飽和Na 2CO 3水溶液(10 mL)及鹽水(10 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由製備型HPLC（管柱：Boston Prime C18 150*30 mm*5um；移動相：[水(NH 3H 2O+NH 4HCO 3)-ACN]；B%：25%至55%，7min）純化，以得到(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮（108 mg，41.6%產率）。LCMS: m/z 446.2 [M+H] +。 步驟2：SFC分離
將化合物(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮(100 mg, 224 µmol)藉由SFC（管柱：Phenomenex-Cellulose-2 (250 mm*30 mm,10um)；移動相：[0.1%NH 3H 2O EtOH]；B%:55%%，等度洗提模式）分離，以得到鏡像異構物1（20.1 mg，19.5%產率，Rt=1.879 min）及鏡像異構物2（23.3 mg，22.7%產率，Rt=4.054 min）。
鏡像異構物1（實例1628）：(S)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮。 1H NMR (400 MHz, CD 3OD) δ 8.32-8.78 (m, 3 H), 7.97 (d, 1 H), 7.68 (s, 1 H), 7.45 (d, 1 H), 6.54-7.10 (m, 4 H), 4.62-4.75 (m, 1 H), 4.55 (s, 2 H), 3.40-3.60 (m, 4 H), 3.02-3.17 (m, 1 H), 2.79 (br dd, 1 H)；LCMS: m/z 446.1 [M+H] +；SFC：100%。
鏡像異構物2（實例1629）：(R)-(4-(4-氟吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)(6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-基)甲酮。 1H NMR (400 MHz, CD 3OD) δ 8.31-8.88 (m, 3 H), 7.97 (d, 1 H), 7.68 (s, 1 H), 7.45 (dd, 1 H), 6.55-7.06 (m, 4 H), 4.62-4.73 (m, 1 H), 4.55 (s, 2 H), 3.40-3.76 (m, 4 H), 2.99-3.17 (m, 1 H), 2.79 (br dd, 1 H)；LCMS: m/z 446.2 [M+H] +；SFC：99.8%。
根據一般方案1方法A2製備實例1756及1757 步驟1：製備2,2,2-三氟-1-[4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫咪唑并[4,5-c]吡啶-5-基]乙酮
在0℃下，向4-(4-氟吡唑并[1,5-a]吡啶-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(7.3 g, 28.4 mmol)及Et 3N (11.49 g, 114 mmol, 15.8 mL)在DCM (150 mL)中之溶液中，逐滴添加TFAA (15.50 g, 73.8 mmol, 10.3 mL)。添加完成後，將反應混合物在室溫下攪拌3小時。使用TLC檢查反應進程。將DCM (150 mL)添加至反應混合物中，且將有機層用水(100 mL)及鹽水(100 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至15% MeOH/DCM，在60 mL/min下）純化，以得到化合物2,2,2-三氟-1-[4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫咪唑并[4,5-c]吡啶-5-基]乙酮（10 g，94.4%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.55-8.68 (m, 1 H), 7.60-7.76 (m, 1 H), 7.15 (dd, 1 H), 6.90 (td, 1 H), 6.66-6.73 (m, 1 H), 6.63 (s, 1 H), 4.10 (br s, 1 H), 3.67-3.80 (m, 1 H), 2.70-2.88 (m, 2 H)；LCMS: m/z 354.2 [M+H] +。 步驟2：製備2,2,2-三氟-1-[4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1-四氫哌喃-2-基-6,7-二氫-4H-咪唑并[4,5-c]吡啶-5-基]乙酮
向2,2,2-三氟-1-[4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1,4,6,7-四氫咪唑并[4,5-c]吡啶-5-基]乙酮(10 g, 28.3 mmol)及DHP (7.14 g, 84.9 mmol, 7.76 mL)在甲苯(140 mL)中之溶液中，添加TsOH (487 mg, 2.83 mmol)，且將反應混合物在120℃下攪拌12小時。使用LCMS及TLC檢查反應進程。添加EtOAc (150 ml)，且將有機層用鹽水(40 ml × 2)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至10% MeOH/DCM，梯度在60 mL/min下）純化，以得到化合物2,2,2-三氟-1-[4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1-四氫哌喃-2-基-6,7-二氫-4H-咪唑并[4,5-c]吡啶-5-基]乙酮（8.9 g，64.8%產率）。 1HNMR (400 MHz, DMSO- d 6) δ 8.54-8.66 (m, 1 H), 7.73-7.90 (m, 1 H), 7.11-7.20 (m, 1 H), 6.67-6.93 (m, 2 H), 6.12-6.61 (m, 1 H), 5.14-5.37 (m, 1 H), 3.92-4.16 (m, 2 H), 3.60-3.84 (m, 2 H), 2.80-2.97 (m, 2 H), 1.87-2.06 (m, 3 H), 1.49-1.70 (m, 3 H)；LCMS: m/z 438.3 [M+H] +。 步驟3：製備4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1-四氫哌喃-2-基-4,5,6,7-四氫咪唑并[4,5-c]吡啶
將2,2,2-三氟-1-[4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1-四氫哌喃-2-基-6,7-二氫-4H-咪唑并[4,5-c]吡啶-5-基]乙酮(8.8 g, 20.1 mmol)及K 2CO 3(12.51 g, 90.5 mmol)在MeOH (100 mL)中之混合物除氣且用N 2吹掃3次，且接著將反應混合物在室溫下在N 2氣氛下攪拌12小時。使用LCMS及TLC檢查反應進程。將DCM (150 mL)添加至反應混合物中，且將有機層用H 2O (2 × 40 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；80 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至10% MeOH:DCM，在60 mL/min下）純化，以得到化合物4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1-四氫哌喃-2-基-4,5,6,7-四氫咪唑并[4,5-c]吡啶（5.8 g，79.4%產率）。 1H NMR (400 MHz, DMSO- d 6) δ 8.52 (d, 1 H), 7.62 (d, 1 H), 7.02-7.10 (m, 1 H), 6.77-6.85 (m, 1 H), 6.49 (d, 1 H), 5.15-5.24 (m, 1 H), 5.06 (d, 1 H), 3.95-4.11 (m, 2 H), 3.56-3.69 (m, 1 H), 2.94 (br dd, 1 H), 2.57-2.70 (m, 2 H), 1.89-2.06 (m, 3 H), 1.46-1.70 (m, 3 H)；LCMS: m/z 342.2 [M+H] +。 步驟4：製備4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-吡𠯤-2-基-1-四氫哌喃-2-基-6,7-二氫-4H-咪唑并[4,5-c]吡啶
將2-溴吡𠯤(1.40 g, 8.79 mmol)、4-(4-氟吡唑并[1,5-a]吡啶-2-基)-1-四氫哌喃-2-基-4,5,6,7-四氫咪唑并[4,5-c]吡啶(1.5 g, 4.39 mmol)、CPhos-Pd-G3 (177.15 mg, 220 µmol)、Cs 2CO 3(4.29 g, 13.2 mmol)在三級戊醇(20 mL)中之混合物除氣且用N 2吹掃3次，且接著將反應混合物在100℃下在N 2氣氛下攪拌12小時。使用LCMS檢查反應進程。將DCM (100 mL)添加至反應混合物中，且將有機層用水(40 mL)及鹽水(40 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；24 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至10% MeOH:DCM，在30 mL/min下）純化，以得到4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-吡𠯤-2-基-1-四氫哌喃-2-基-6,7-二氫-4H-咪唑并[4,5-c]吡啶（1 g，50.3%產率）。LCMS: m/z 420.2 [M+H] +。 步驟5：製備4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶
在室溫下，向4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-吡𠯤-2-基-1-四氫哌喃-2-基-6,7-二氫-4H-咪唑并[4,5-c]吡啶(1 g, 2.38 mmol)在MeOH (15 mL)中之溶液中，添加HCl (4 M, 20.0 mL)。將反應混合物在70℃下攪拌12小時。使用LCMS檢查反應進程。添加DCM (100 mL)，且將有機層用飽和Na 2CO 3水溶液(50 mL × 2)及鹽水(50 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由快速矽膠層析（ISCO ®；24 g SepaFlash ®二氧化矽快速管柱，洗提液為0%至10% MeOH:DCM，在30 mL/min下）純化，以得到4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶（500 mg，58.3%產率）。LCMS: m/z 336.2 [M+H] +。 步驟6：SFC分離
將化合物4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(1.2 g, 3.58 mmol)藉由SFC（管柱：DAICEL CHIRALPAK AD(250 mm*30 mm,10um)；移動相：[CO 2-EtOH(0.1%NH 3H 2O)]；B%:40%%，等度洗提模式）分離，以得到鏡像異構物1（370 mg，28.8%產率，Rt=0.530 min）及鏡像異構物2（433 mg，33.4%產率，Rt=0.931 min）。
鏡像異構物1（實例1756）：(R)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶。 1H NMR (400 MHz, CD 3OD) δ 8.46 (s, 1 H), 8.34 (d, 1 H), 8.16 (s, 1 H), 7.80 (d, 1 H), 7.65 (s, 1 H), 6.88-7.00 (m, 1 H), 6.77-6.87 (m, 2 H), 6.66 (s, 1 H), 4.71 (br dd, 1 H), 3.56-3.67 (m, 1 H), 2.92 - 3.05 (m, 1 H), 2.76 (dd, 1 H)；LCMS: m/z 336.1 [M+H] +；SFC: 100% ee。
鏡像異構物2（實例1757）：(S)-4-(4-氟吡唑并[1,5-a]吡啶-2-基)-5-(吡𠯤-2-基)-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶。 1H NMR (400 MHz, CD 3OD) δ 8.46 (d, 1 H), 8.30-8.37 (m, 1 H), 8.13-8.19 (m, 1 H), 7.80 (d, 1 H), 7.65 (s, 1 H), 6.94 (dd, 1 H), 6.77-6.87 (m, 2 H), 6.65 (s, 1 H), 4.71 (dd, 1 H), 3.61 (ddd, 1 H), 2.92-3.03 (m, 1 H), 2.76 (dd, 1 H)；LCMS: m/z 336.2 [M+H] +；SFC: 99.7% ee。
根據一般方案1方法A1製備實例1842及1843 步驟1：製備2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑
向4-吡唑并[1,5-a]吡啶-2-基-4,5,6,7-四氫-1H-咪唑并[4,5-c]吡啶(200 mg, 836 µmol)在DMF (2 mL)中之溶液中，添加DIPEA (432 mg, 3.34 mmol, 582 µL)及2-溴-5-(2,6-二氟苯基)-1,3,4-㗁二唑(E78) (262 mg, 1.00 mmol)，且將反應混合物在室溫下攪拌12小時。使用TLC檢查反應進程。將DCM (20 mL)添加至反應混合物中，且將有機層用水(20 mL)洗滌，經Na 2SO 4乾燥、過濾且濃縮至乾燥。將殘餘物藉由製備型HPLC（管柱：Welch Xtimate C18 150*30 mm*5um；移動相：[水(NH 3H 2O+NH 4HCO 3)-ACN]；B%：30%-60%，7min）純化，以得到2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑（150 mg，40.8%產率）。LCMS: m/z 420.1 [M+H] +。 步驟2：SFC分離
將化合物2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑(100 mg, 238 µmol)藉由SFC（管柱：DAICEL CHIRALPAK AD(250 mm*30 mm,10um)；移動相：[0.1%NH 3H 2O EtOH]；B%：45%至45%，45min）分離，以得到鏡像異構物1（46.8 mg，46.6%產率，Rt=1.780 min）及鏡像異構物2（47.0 mg，46.8%產率，Rt=1.990 min）。
鏡像異構物1（實例1842）：(R)-2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑。 1H NMR (400 MHz, CD 3OD) δ 8.45 (d, 1 H), 7.49-7.76 (m, 3 H), 7.09-7.30 (m, 3 H), 6.86 (td, 1 H), 6.60 (s, 1 H), 6.41 (s, 1 H), 4.35 (dd, 1 H), 3.73-3.88 (m, 1 H), 2.99-3.17 (m, 1 H), 2.84 (dd, 1 H)；LCMS: m/z 420.2 [M+H] +；SFC: 99.3% ee。
鏡像異構物2（實例1843）：(S)-2-(2,6-二氟苯基)-5-(4-(吡唑并[1,5-a]吡啶-2-基)-6,7-二氫-1H-咪唑并[4,5-c]吡啶-5(4H)-基)-1,3,4-㗁二唑。 1H NMR (400 MHz, CD 3OD) δ 8.45 (d, 1 H), 7.49-7.79 (m, 3 H), 7.12-7.30 (m, 3 H), 6.86 (td, 1 H), 6.61 (s, 1 H), 6.41 (s, 1 H), 4.36 (dd, 1 H), 3.68-3.90 (m, 1 H), 3.00-3.17 (m, 1 H), 2.85 (dd, 1 H)；LCMS: m/z 420.1 [M+H] +；SFC: 99.2% ee。
表1之化合物係使用質子NMR及LCMS表徵，且判定鏡像異構過量。參見表2。 表2
實例# 1H NMR （除非另外指明，否則係400 MHz ） LCMS: m/z % ee
600 (CD 3OD) δ 8.22-8.79 (m, 3 H), 7.98 (d, 1 H), 7.67 (s, 1 H), 7.60 (d, 1 H), 7.39-7.49 (m, 1 H), 7.15-7.24 (m, 1 H), 7.02-7.13 (m, 1 H), 6.87 (br s, 1 H), 6.56 (br s, 1 H), 4.64 (br s, 1 H), 3.38-3.77 (m, 1 H), 2.97-3.18 (m, 1 H), 2.97-3.18 (m, 1 H), 2.70-2.87 (m, 1 H) 384.2 [M+H] + 100%
601 (CD 3OD) δ 8.33-8.97 (m, 3 H), 7.98 (d, 1 H), 7.68 (br s, 1 H), 7.60 (d, 1 H), 7.44 (t, 1 H), 7.21 (t, 1 H), 7.07 (t, 1 H), 6.87 (br s, 1 H), 6.56 (br s, 1 H), 4.65 (br s, 1 H), 3.38-3.83 (m, 1 H), 3.02-3.16 (m, 1 H), 2.70-2.85 (m, 1 H) 384.2 [M+H] + 99.4%
602 (CD 3OD) δ 9.18 (s, 1 H), 8.19-8.81 (m, 2 H), 7.69 (s, 1 H), 7.61 (d, 1 H), 7.22 (br t, 1 H), 6.89 (t, 1.5 H), 6.30-6.69 (m, 1.5 H), 4.06-4.85 (m, 1 H), 3.77 (br s, 1 H), 2.95-3.10 (m, 1 H), 2.78 (d, 1 H) 351.1 [M+H] + 100%
603 (CD 3OD) δ 9.18 (s, 1 H), 8.16-8.80 (m, 2 H), 7.69 (s, 1 H), 7.61 (d, 1 H), 7.22 (t, 1 H), 6.80-6.95(m, 1.5 H), 6.25-6.72 (m, 1.5 H), 4.14-4.84 (m, 1 H), 3.52-3.89 (m, 1 H), 3.52-3.53 (m, 1 H), 2.95-3.15 (m, 1 H), 2.70-2.85 m, 1 H) 351.1 [M+H] + 100%
604 (CD 3OD) δ 8.70-8.85 (m, 1 H), 8.38-8.53 (m, 2 H), 8.31 (dd, 1 H), 8.09 (td, 1 H), 7.52-7.74 (m, 2.3 H), 7.17-7.32 (m, 1 H), 7.10 (s, 0.7 H), 6.83-6.96 (m, 1 H), 6.67-6.80 (m, 1 H), 5.12 (dd, 1 H), 3.69-3.86 (m, 0.7 H), 3.41-3.49 (m, 0.3 H), 3.19-3.28 (m, 0.4 H), 3.01-3.18 (m, 0.6 H), 2.91-2.99 (m, 1 H) 413.0 [M+H] + 99.5%
605 (CD 3OD) δ 8.72-8.81 (m, 1 H), 8.34-8.51 (m, 1 H), 8.25-8.33 (m, 1 H), 8.07 (td, 1 H), 7.45-7.76 (m, 3.4 H), 7.12-7.26 (m, 1 H), 6.97 (s, 0.6 H), 6.78-6.90 (m, 1 H), 6.52-6.74 (m, 1 H), 4.99 (br dd, 1 H), 3.72-3.88 (m, 0.7 H), 3.42 (td, 0.3 H), 3.14-3.23 (m, 0.5 H), 2.92-3.07 (m, 0.5 H), 2.79-2.89 (m, 1 H) 413.0 [M+H] + 100%
606 (CD 3OD) δ 8.44 (d, 1 H), 8.25 (s, 1 H), 7.51-7.72 (m, 2 H), 7.10-7.24 (m, 1 H), 6.84 (t, 1.6 H), 6.61 (br s, 1.4 H), 4.30 (br s, 1 H), 3.53-3.86 (m, 1 H), 2.93-3.11 (m, 1 H), 2.78 (br d, 1 H), 2.38 (s, 3 H) 349.0 [M+H] + 100%
607 (CD 3OD) δ 8.44 (d, 1 H), 8.25 (s, 1 H), 7.51-7.73 (m, 2 H), 7.10-7.30 (m, 1 H), 6.73-6.95 (m, 1.7 H), 6.60 (br s, 1.3 H), 4.31 (br s, 1 H), 3.51-3.81 (m, 1 H), 2.95-3.17 (m, 1 H), 2.69-2.89 (m, 1 H), 2.38 (s, 3 H) 349.0 [M+H] + 99.8%
608 (CD 3OD) δ 8.39-8.56 (m, 1 H), 8.10-8.17 (m, 1 H), 7.67 (br d, 1 H), 7.58 (d, 1 H), 7.18-7.23 (m, 1 H), 6.84-6.93 (m, 1.6 H), 6.44-6.62 (m, 1.4 H), 4.77-4.89 (m, 1.4 H), 4.67-4.76 (m, 0.4 H), 4.39-4.47 (m, 0.6 H), 4.30 (dd, 0.6 H), 3.62-3.74 (m, 0.6 H), 3.19 (td, 0.4 H), 2.82-3.01 (m, 1 H), 2.67-2.81 (m, 1 H) 433.1 [M+H] + 100%
609 (CD 3OD) δ 8.40-8.55 (m, 1 H), 8.09-8.17 (m, 1 H), 7.65-7.69 (m, 1 H), 7.58 (d, 1 H), 7.17-7.23 (m, 1 H), 6.83-6.93 (m, 1.6 H), 6.44-6.59 (m, 1.4 H), 4.81-4.89 (m, 1.5 H), 4.68-4.77 (m, 0.4 H), 4.40-4.46 (m, 0.5 H), 4.30 (dd, 0.6 H), 3.69 (ddd, 0.6 H), 3.19 (td, 0.4 H), 2.81-3.01 (m, 1 H), 2.68-2.81 (m, 1 H) 433.1 [M+H] + 99.8%
610 (CD 3OD) δ 8.34-8.55 (m, 2 H), 7.49-7.74 (m, 2 H), 7.13-7.24 (m, 1 H), 6.79-6.94 (m, 2 H), 6.59 (s, 0.6 H), 6.38 (s, 0.2 H), 5.98 (br s, 0.2 H), 4.82 (br d, 0.3 H), 3.65-3.85 (m, 1.5 H), 3.39-3.49 (m, 0.2 H), 2.70-3.02 (m, 2 H) 403.1 [M+H] + 99.0%
611 (CD 3OD) δ 8.35-8.54 (m, 2 H), 7.45-7.75 (m, 2 H), 7.12-7.28 (m, 1 H), 6.79-6.96 (m, 2 H), 6.60 (s, 0.6 H), 6.39 (s, 0.2 H), 5.99 (br s, 0.2 H), 4.83 (br d, 0.3 H), 3.66-3.87 (m, 1.4 H), 3.45 (td, 0.3 H), 2.70-3.04 (m, 2 H) 403.1 [M+H] + 97.5%
612 (CD 3OD) δ 8.42-8.66 (m, 1.5 H), 8.18 (br s, 0.5 H), 7.65 (s, 1 H), 7.57 (br d, 1 H), 7.13-7.23 (m, 1 H), 6.85 (br s, 1 H), 6.28-6.66 (m, 2 H), 4.23 (br s, 1 H), 3.76 (br s, 1 H), 3.01 (br s, 1 H), 2.75 (br d, 1 H), 2.10 (t, 3 H) 415.0 [M+H] + 99.2%
613 (CD 3OD) δ 8.39-8.68 (m, 1.6 H), 8.18 (br s, 0.4 H), 7.65 (s, 1 H), 7.57 (br d, 1 H), 7.12-7.23 (m, 1 H), 6.86 (br s, 1 H), 6.22-6.65 (m, 2 H), 4.22 (br s, 1 H), 3.76 (br s, 1 H), 3.01 (br s, 1 H), 2.75 (br d, 1 H), 2.10 (t, 3 H) 415.0 [M+H] + 99.3%
614 (CD 3OD) δ 8.40-8.52 (m, 1 H), 7.54-7.68 (m, 2 H), 7.16-7.24 (m, 1 H), 6.81-6.95 (m, 1.6 H), 6.55 (s, 0.6 H), 6.42 (s, 0.4 H), 6.26 (s, 0.4 H), 4.82-4.88 (m, 0.6 H), 4.16 (dd, 0.4 H), 3.56-3.68 (m, 0.6 H), 3.14 (td, 0.4 H), 2.41-2.99 (m, 4 H), 1.03-1.13 (m, 1 H), 0.48-0.62 (m, 2 H), 0.16-0.29 (m, 2 H) 322.1 [M+H] + 99.9%
615 (CD 3OD) δ 8.40-8.53 (m, 1 H), 7.53-7.69 (m, 2 H), 7.14-7.24 (m, 1 H), 6.80-6.95 (m, 1.6 H), 6.55 (s, 0.6 H), 6.42 (s, 0.4 H), 6.26 (s, 0.4 H), 4.81-4.87 (m, 0.4 H), 4.16 (dd, 1 H), 3.56-3.67 (m, 0.6 H), 3.08-3.20 (m, 0.4 H), 2.42-2.97 (m, 4 H), 1.03-1.15 (m, 1 H), 0.48-0.62 (m, 2 H), 0.17-0.29 (m, 2 H) 322.2 [M+H] + 99.9%
616 (CD 3OD) δ 8.57-8.68 (m, 1 H), 8.33-8.48 (m, 1 H), 7.91 (t, 1 H), 7.70-7.78 (m, 1 H), 7.68 (s, 1 H), 7.53-7.61 (m, 1 H), 7.46 (s, 0.3 H), 7.09-7.26 (m, 1 H), 6.95 (s, 0.7 H), 6.75-6.88 (m, 1 H), 6.53-6.68 (m, 1 H), 4.95 (br d, 1 H), 3.72-3.86 (m, 0.8 H), 3.37-3.46 (m, 0.2 H), 2.94-3.26 (m, 1 H), 2.83 (br d, 1 H) 431.1 [M+H] + 100%
617 (CD 3OD) δ 8.53-8.80 (m, 1 H), 8.31-8.50 (m, 1 H), 7.85-7.98 (m, 1 H), 7.70-7.77 (m, 1 H), 7.68 (s, 1 H), 7.52-7.62 (m, 1 H), 7.46 (s, 0.3 H), 7.10-7.23 (m, 1 H), 6.95 (s, 0.7 H), 6.75-6.88 (m, 1 H), 6.56-6.69 (m, 1 H), 4.95 (br d, 1 H), 3.72-3.84 (m, 0.7 H), 3.35-3.47 (m, 0.5 H), 2.93-3.21 (m, 1 H), 2.74-2.90 (m, 1 H) 431.1 [M+H] + 100%
618 (CD 3OD) δ 8.41 (d, 1 H), 8.11 (s, 1 H), 7.51-7.66 (m, 2 H), 7.11-7.20 (m, 1 H), 6.82 (td, 2 H), 6.56 (br s, 1 H), 4.34 (br s, 1 H), 3.51-3.86 (m, 1 H), 2.92-3.12 (m, 1 H), 2.76 (br dd, 1 H), 2.19-2.42 (m, 1 H), 0.84-1.03 (m, 4 H) 375.0 [M+H] + 99.8%
619 (CD 3OD) δ 8.42 (d, 1 H), 8.11 (s, 1 H), 7.51-7.67 (m, 2 H), 7.11-7.21 (m, 1 H), 6.77-6.85 (m, 2 H), 6.56 (br s, 1 H), 4.32 (br s, 1 H), 3.68 (br s, 1 H), 3.01 (br s, 1 H), 2.76 (br dd, 1 H), 2.32 (br s, 1 H), 0.84-1.00 (m, 4 H) 375.0 [M+H] + 99.7%
620 (CD 3OD) δ 8.42-8.48 (m, 1 H), 7.70 (s, 1 H), 7.57-7.63 (m, 1 H), 7.18-7.24 (m, 1 H), 6.83-6.95 (m, 2 H), 6.53-6.64 (m, 1 H), 4.99 (br dd, 1 H), 3.69-3.79 (m, 0.7 H), 3.35-3.44 (m, 0.3 H), 3.07-3.20 (m, 0.7 H), 2.91-3.04 (m, 0.3 H), 2.77-2.87 (m, 1 H), 2.26-2.39 (m, 1 H), 1.19-1.33 (m, 4 H) 376.0 [M+H] + 100%
621 (CD 3OD) δ 8.41-8.48 (m, 1 H), 7.69 (s, 1 H), 7.57-7.64 (m, 1 H), 7.18-7.24 (m, 1 H), 6.80-6.97 (m, 2 H), 6.53-6.65 (m, 1 H), 4.99 (br dd, 1 H), 3.74 (ddd, 0.7 H), 3.36-3.44 (m, 0.3 H), 3.07-3.20 (m, 0.7 H), 2.90-3.03 (m, 0.3 H), 2.75-2.88 (m, 1 H), 2.26-2.39 (m, 1 H), 1.17-1.32 (m, 4 H) 376.0 [M+H] + 99.9%
622 (CD 3OD) δ 8.65 (br d, 1 H), 8.43 (br d, 1 H), 7.89-8.18 (m, 2 H), 7.65 (br s, 1 H), 7.58 (br d, 1 H), 7.48-7.54 (m, 1 H), 7.13-7.22 (m, 1 H), 6.61-6.92 (m, 3 H), 4.49 (br s, 1 H), 3.76 (br s, 1 H), 3.18 (br s, 1 H), 2.80 (br d, 1 H), 2.40 (br s, 1 H), 0.87-1.14 (m, 4 H) 452.2 [M+H] + 99.7%
623 (CD 3OD) δ 8.65 (br d, 1 H), 8.43 (br d, 1 H), 7.85-8.16 (m, 2 H), 7.65 (s, 1 H), 7.57 (br d, 1 H), 7.47-7.54 (m, 1 H), 7.14-7.20 (m, 1 H), 6.58-6.93 (m, 3 H), 4.42-4.63 (m, 1 H), 3.76 (br s, 1 H), 3.18 (br s, 1 H), 2.80 (br d, 1 H), 2.40 (br s, 1 H), 0.89-1.14 (m, 4 H) 452.2 [M+H] + 99.6%
624 (CD 3OD) δ 8.42 (d, 1 H), 7.52-7.66 (m, 2 H), 7.13-7.21 (m, 1 H), 6.82 (t, 2 H), 6.59 (s, 1 H), 4.35 (br s, 1 H), 3.69 (br s, 1 H), 3.09 (br d, 1 H), 2.76 (br d, 1 H), 2.33 (br s, 1 H), 1.55 (br s, 6 H), 0.80-1.05 (m, 4 H) 433.2 [M+H] + 100%
625 (CD 3OD) δ 8.42 (d, 1 H), 7.52-7.66 (m, 2 H), 7.13-7.20 (m, 1 H), 6.82 (t, 2 H), 6.59 (s, 1 H), 4.34 (br s, 1 H), 3.66 (br s, 1 H), 2.90-3.17 (m, 1 H), 2.76 (br d, 1 H), 2.33 (br s, 1 H), 1.55 (br s, 6 H), 0.79-1.04 (m, 4 H) 433.1 [M+H] + 99.5%
626 (CD 3OD) δ 8.36-8.48 (m, 2 H), 8.10 (s, 1 H), 7.68 (s, 1 H), 7.53-7.63 (m, 1 H), 7.14-7.23 (m, 1 H), 6.94 (br s, 1 H), 6.81-6.89 (m, 1 H), 6.52-6.65 (m, 1 H), 4.96-5.10 (m, 0.7 H), 4.68-4.79 (m, 0.4 H), 4.00 (s, 3 H), 3.71-3.81 (m, 0.7 H), 3.36-3.51 (m, 0.4 H), 2.95-3.23 (m, 1 H), 2.83 (br d, 1 H) 416.2 [M+H] + 100%
627 (CD 3OD) δ 8.34-8.48 (m, 2 H), 8.11 (s, 1 H), 7.69 (s, 1 H), 7.53-7.63 (m, 1 H), 7.14-7.25 (m, 1 H), 6.96 (br s, 1 H), 6.80-6.90 (m, 1 H), 6.54-6.65 (m, 1 H), 5.06 (br dd, 0.7 H), 4.76-4.80 (m, 0.6 H), 4.01 (s, 3 H), 3.72-3.82 (m, 0.6 H), 3.40 (td, 0.4 H), 2.93-3.23 (m, 1 H), 2.83 (br d, 1 H) 416.2 [M+H] + 99.6%
628 (CD 3OD) δ 8.47 (br d, 1 H), 7.53-7.77 (m, 2 H), 7.15-7.27 (m, 1 H), 6.83-6.95 (m, 2 H), 6.44-6.67 (m, 1 H), 3.80 (br d, 1.5 H), 3.41-3.55 (m, 0.5 H), 2.74-3.07 (m, 2 H), 1.55-1.74 (m, 6 H) 461.0 [M+H] + 100%
629 (CD 3OD) δ 8.39-8.51 (m, 1 H), 7.55-7.72 (m, 2 H), 7.31-7.53 (m, 0.5 H), 7.15-7.26 (m, 1 H), 6.80-6.95 (m, 1.5 H), 6.42-6.65 (m, 1 H), 3.80 (br d, 1.4 H), 3.50 (br d, 0.6 H), 2.73-3.10 (m, 2 H), 1.51-1.73 (m, 6 H) 461.0 [M+H] + 99.6%
630 (DMSO- d 6) δ 11.89-12.21 (m, 1 H), 8.51-8.79 (m, 2 H), 7.44-7.76 (m, 2 H), 7.07-7.41 (m, 2 H), 6.28-6.94 (m, 3 H), 4.69 (br s, 0.4 H), 4.23 (br d, 0.6 H), 3.57-3.81 (m, 0.5 H), 3.17-3.29 (m, 0.5 H), 2.58-2.98 (m, 2 H) 385.1 [M+H] + 100%
631 (CD 3OD) δ 8.39-8.48 (m, 2 H), 7.68 (s, 1 H), 7.59 (br d, 1 H), 6.99-7.30 (m, 2 H), 6.44-6.92 (m, 3 H), 4.96-5.10 (m, 0.5 H), 4.31 (br d, 0.7 H), 3.73 (br s, 0.5 H), 3.48 (br d, 0.3 H), 2.92-3.16 (m, 1 H), 2.80 (br d, 1 H) 385.1 [M+H] + 99.7%
632 (CD 3OD) δ 8.43 (br d, 1 H), 7.65 (s, 1 H), 7.57 (d, 1 H), 6.91-7.27 (m, 2 H), 6.73-6.91 (m, 1.6 H), 6.57 (br s, 1.4 H), 4.65-4.79 (m, 0.5 H), 4.30 (br s, 0.5 H), 3.37-3.91 (m, 1 H), 2.88-3.11 (m, 1 H), 2.79 (br d, 1 H), 2.00-2.34 (m, 1 H), 0.98-1.26 (m, 4 H) 425.0 [M+H] + 95.8%
633 (CD 3OD) δ 8.43 (br d, 1 H), 7.65 (s, 1 H), 7.57 (d, 1 H), 7.02-7.33 (m, 2 H), 6.73-7.01 (m, 2 H), 6.50-6.60 (m, 1 H), 4.69-4.80 (m, 0.5 H), 4.31 (br s, 0.5 H), 3.67 (br s, 1 H), 2.92-3.21 (m, 1 H), 2.79 (br d, 1 H), 1.97-2.38 (m, 1 H), 1.05-1.26 (m, 4 H) 425.0 [M+H] + 99.1%
634 (CD 3OD) δ 8.28-8.41 (m, 1 H), 7.41-7.57 (m, 2 H), 7.03-7.12 (m, 1 H), 6.83 (s, 0.6 H), 6.69-6.79 (m, 1 H), 6.29-6.47 (m, 1.4 H), 4.73 (br d, 0.5 H), 4.17 (br dd, 0.5 H), 3.41-3.54 (m, 0.6 H), 2.95-3.06 (m, 1 H), 2.55-2.90 (m, 3.4 H), 1.91-2.16 (m, 4 H), 1.50-1.76 (m, 2 H) 352.2 [M+H] + 100%
635 (CD 3OD) δ 8.37-8.54 (m, 1 H), 7.52-7.71 (m, 2 H), 7.13-7.25 (m, 1 H), 6.95 (s, 0.6 H), 6.79-6.90 (m, 1 H), 6.40-6.58 (m, 1.4 H), 4.85 (br d, 0.4 H), 4.30 (dd, 0.6 H), 3.59 (ddd, 0.6 H), 3.11-3.16 (m, 1 H), 2.67-3.03 (m, 3.4 H), 2.03-2.27 (m, 4 H), 1.62-1.88 (m, 2 H) 352.2 [M+H] + 99.5%
636 (CD 3OD) δ 8.40-8.54 (m, 1 H), 7.62-7.69 (m, 1 H), 7.58 (d, 1 H), 7.15-7.24 (m, 1 H), 6.79-6.93 (m, 2 H), 6.37-6.54 (m, 1 H), 4.82 (br dd, 1 H), 4.16 (br dd, 1 H), 3.47-3.66 (m, 1 H), 2.87-3.18 (m, 2 H), 2.68-2.82 (m, 3 H), 2.30-2.51 (m, 2 H), 2.19 (br d, 2 H) 354.2 [M+H] + 100%
637 (CD 3OD) δ 8.38-8.53 (m, 1 H), 7.61-7.69 (m, 1 H), 7.57 (d, 1 H), 7.14-7.23 (m, 1 H), 6.77-6.92 (m, 2 H), 6.36-6.54 (m, 1 H), 5.03-5.25 (m, 1 H),4.15 (br dd, 1 H), 3.46-3.66 (m, 1 H), 2.85-3.15 (m, 2 H), 2.66-2.81 (m, 3 H), 2.29-2.60 (m, 2 H), 2.07-2.25 (m, 2 H) 354.2 [M+H] + 83.3%
638 (CD 3OD) δ 8.43 (br d, 1 H), 7.48-7.68 (m, 2 H), 7.10-7.23 (m, 1 H), 6.71-6.88 (m, 2 H), 6.40-6.59 (m, 1 H), 4.54-4.64 (m, 1 H), 3.46-3.65 (m, 1 H), 2.83-3.06 (m, 1 H), 2.67-2.79 (m, 1 H), 2.55-2.66 (m, 2 H), 2.02-2.16 (m, 2 H), 1.91-2.02 (m, 1 H), 1.77 (br d, 1 H) 388.2 [M+H] + 100%
639 (CD 3OD) δ 8.43 (br d, 1 H), 7.47-7.71 (m, 2 H), 7.09-7.22 (m, 1 H), 6.71-6.93 (m, 2 H), 6.40-6.59 (m, 1 H), 4.58 (br dd, 1 H), 3.58 (br t, 1 H), 2.80-3.04 (m, 1 H), 2.67-2.78 (m, 1 H), 2.55-2.66 (m, 2 H), 2.08 (br d, 2 H), 1.98 (dt, 1 H), 1.70-1.84 (m, 1 H) 388.1 [M+H] + 99.6%
640 以上所提供之數據
641 以上所提供之數據
642 (CD 3OD) δ 8.33-8.68 (m, 3 H), 7.96 (d, 2 H), 7.73 (br s, 1 H), 7.49-7.67 (m, 1.4 H), 7.17-7.31 (m, 1 H), 7.00 (br s, 0.6 H), 6.78-6.95 (m, 1 H), 6.56-6.74 (m, 1 H), 5.10 (br dd, 0.7 H), 4.96-4.99 (m, 0.3 H), 3.76-3.90 (m, 0.6 H), 3.40-3.53 (m, 0.4 H), 2.99-3.28 (m, 1 H), 2.88 (br d, 1 H) 480.2 [M+H] + 100%
643 (CD 3OD) δ 8.13-8.55 (m, 3 H), 7.83 (br d, 2 H), 7.32-7.74 (m, 2 H), 7.00-7.18 (m, 1 H), 6.66-6.96 (m, 2 H), 6.38-6.61 (m, 1 H), 4.97 (br dd, 1 H), 3.59-3.83 (m, 0.7 H), 3.28-3.36 (m, 0.3 H), 2.85-3.15 (m, 1 H), 2.77 (br s, 1 H) 480.2 [M+H] + 99.2%
644 (CD 3OD) δ 8.74 (br d, 1 H), 8.47 (br d, 1 H), 8.30 (br d, 1 H), 7.90-8.10 (m, 1 H), 7.54-7.77 (m, 3 H), 7.05-7.42 (m, 2 H), 6.58-6.97 (m, 3 H), 4.52 (br d, 1 H), 3.43-3.86 (m, 1 H), 2.92-3.25 (m, 1 H), 2.78-2.91 (m, 1 H) 462.1 [M+H] + 100%
645 (CD 3OD) δ 8.74 (br d, 1 H), 8.47 (br d, 1 H), 8.13-8.34 (m, 1 H), 7.89-8.10 (m, 1 H), 7.56-7.79 (m, 3 H), 7.05-7.40 (m, 2 H), 6.51-7.00 (m, 3 H), 4.51 (br d, 1 H), 3.45-3.87 (m, 1 H), 2.92-3.26 (m, 1 H), 2.86 (br d, 1 H) 462.1 [M+H] + 99.5%
646 (CD 3OD) δ 8.59 (s, 1 H), 8.37-8.48 (m, 1 H), 8.22 (s, 1 H), 7.54-7.72 (m, 2 H), 7.13-7.24 (m, 1 H), 6.78-6.99 (m, 2 H), 6.53-6.66 (m, 1 H), 5.02-5.17 (m, 3 H), 3.74-3.81 (m, 0.5 H), 3.38-3.47 (m, 0.5 H), 2.77-3.23 (m, 2 H) 484.1 [M+H] + 100%
647 (CD 3OD) δ 8.59 (s, 1 H), 8.37-8.47 (m, 1 H), 8.22 (s, 1 H), 7.54-7.72 (m, 2 H), 7.14-7.24 (m, 1 H), 6.80-6.99 (m, 2 H), 6.54-6.67 (m, 1 H), 5.02-5.16 (m, 3 H), 3.72-3.82 (m, 0.6 H), 3.38-3.45 (m, 0.4 H), 2.80-3.16 (m, 2 H) 484.1 [M+H] + 98.3%
648 (CD 3OD) δ 8.35-8.56 (m, 1 H), 8.06-8.15 (m, 1 H), 7.98-8.05 (m, 1 H), 7.71 (br s, 1 H), 7.49-7.66 (m, 2.4 H), 7.15-7.28 (m, 1 H), 6.98 (s, 0.6 H), 6.81-6.94 (m, 1 H), 6.56-6.71 (m, 1 H), 5.09 (dd, 0.7 H), 4.94-4.96 (m, 0.3 H), 3.71-3.88 (m, 0.7 H), 3.43 (td, 0.3 H), 3.13-3.26 (m, 0.7 H), 2.95-3.08 (m, 0.3 H), 2.86 (br d, 1 H) 448.1 [M+H] + 100%
649 (CD 3OD) δ 8.35-8.63 (m, 1 H), 8.05-8.15 (m, 1 H), 7.97-8.05 (m, 1 H), 7.71 (br s, 1 H), 7.47-7.66 (m, 2.4 H), 7.08-7.32 (m, 1 H), 6.76-7.06 (m, 1.6 H), 6.51-6.74 (m, 1 H), 5.08 (br dd, 0.7 H), 4.95-5.00 (m, 0.3 H), 3.70-3.89 (m, 0.7 H), 3.38-3.48 (m, 0.3 H), 3.11-3.28 (m, 0.7 H), 2.96-3.09 (m, 0.3 H), 2.86 (br d, 1 H) 448.1 [M+H] + 100%
650 (CD 3OD) δ 8.93 (br d, 1 H), 8.24-8.57 (m, 2 H), 7.46-7.89 (m, 3 H), 7.21 (br s, 1 H), 6.74-7.07 (m, 2 H), 6.50-6.69 (m, 1 H), 5.05 (br s, 1 H), 3.79 (br s, 1 H), 2.75-3.26 (m, 2 H) 452.0 [M+H] + 100%
651 (CD 3OD) δ 8.94 (s, 1 H), 8.31-8.50 (m, 2 H), 7.48-7.86 (m, 3 H), 7.14-7.31 (m, 1 H), 6.78-7.03 (m, 2 H), 6.52-6.69 (m, 1 H), 5.07 (br dd, 1 H), 3.36-3.87 (m, 1 H), 2.79-3.25 (m, 2 H) 452.0 [M+H] + 99.6%
652 (CD 3OD) δ 8.39-8.52 (m, 1 H), 8.17-8.31 (m, 1 H), 7.71 (s, 1 H), 7.53-7.66 (m, 1.3 H), 7.16-7.38 (m, 3 H), 6.98 (s, 0.7 H), 6.82-6.93 (m, 1 H), 6.57-6.70 (m, 1 H), 5.03 (dd, 0.7 H), 4.94-4.96 (m, 0.3 H), 3.74-3.86 (m, 0.7 H), 3.43 (td, 0.3 H), 3.16-3.26 (m, 0.7 H), 2.97-3.07 (m, 0.3 H), 2.81-2.91 (m, 1 H) 448.2 [M+H] + 100%
653 (CD 3OD) δ 8.26-8.39 (m, 1 H), 8.11 (td, 1 H), 7.64 (br s, 1 H), 7.41-7.54 (m, 1.3 H), 7.07-7.25 (m, 3 H), 6.87 (s, 0.7 H), 6.71-6.80 (m, 1 H), 6.46-6.58 (m, 1 H), 4.92 (br dd, 0.7 H), 4.82-4.85 (m, 0.3 H), 3.63-3.73 (m, 0.7 H), 3.27-3.36 (m, 0.3 H), 3.06-3.14 (m, 0.7 H), 2.85-2.97 (m, 0.3 H), 2.69-2.80 (m, 1 H) 448.2 [M+H] + 98.6%
654 (DMSO- d 6) δ 11.97-12.17 (m, 1 H), 8.48-8.69 (m, 1 H), 7.88-8.08 (m, 1 H), 7.50-7.70 (m, 2 H), 7.33-7.40 (m, 1 H), 7.13-7.32 (m, 2 H), 7.08 (s, 0.2 H), 6.95 (br s, 1.2 H), 6.48-6.61 (m, 1.6 H), 4.67-4.86 (m, 1 H), 3.62-3.79 (m, 1 H), 2.71-3.11 (m, 2 H), 2.58-2.67 (m, 3 H) 444.1 [M+H] + 100%
655 (DMSO- d 6) δ 12.03-12.18 (m, 1 H), 8.54-8.70 (m, 1 H), 7.95-8.07 (m, 1 H), 7.57-7.71 (m, 2 H), 7.36-7.43 (m, 1 H), 7.27-7.35 (m, 2 H), 6.80-6.90 (m, 1 H), 6.55-6.63 (m, 1 H), 4.72-4.88 (m, 1 H), 3.61-3.85 (m, 1 H), 2.89-3.18 (m, 1 H), 2.79 (br d, 1 H), 2.61-2.69 (m, 3 H) 444.1 [M+H] + 100%
656 (CD 3OD) δ 8.42-8.56 (m, 1 H), 7.50-7.84 (m, 4 H), 6.73-7.26 (m, 4 H), 6.24-6.64 (m, 1 H), 4.81 (br s, 1 H), 4.07 (br d, 0.5 H), 3.71 (br t, 0.5 H), 2.99 (br s, 1 H), 2.75 (br d, 1 H) 384.1 [M+H] + 100%
657 (CD 3OD) δ 8.41-8.57 (m, 1 H), 7.48-7.85 (m, 4 H), 6.73-7.25 (m, 4 H), 6.23-6.66 (m, 1 H), 4.75-4.86 (m, 1 H), 4.01-4.12 (m, 0.5 H), 3.71 (br s, 0.5 H), 2.99 (br s, 1 H), 2.75 (br d, 1 H) 384.1 [M+H] + 99.7%
658 (CD 3OD) δ 8.34-8.58 (m, 1 H), 7.46-7.90 (m, 3.3 H), 7.10-7.34 (m, 1 H), 6.77-7.02 (m, 2.7 H), 6.47-6.73 (m, 1 H), 5.03 (br dd, 1 H), 4.05 (s, 3 H), 3.79 (br t, 1 H), 2.71-3.21 (m, 2 H) 416.1 [M+H] + 98.1%
659 (CD 3OD) δ 8.31-8.58 (m, 1 H), 7.44-7.96 (m, 3.3 H), 7.14-7.33 (m, 1 H), 6.80-7.10 (m, 2.7 H), 6.52-6.71 (m, 1 H), 5.03 (br dd, 1 H), 4.05 (s, 3 H), 3.70-3.88 (m, 1 H), 2.71-3.23 (m, 2 H) 416.1 [M+H] + 90.6%
660 (CD 3OD) δ 8.42-8.61 (m, 1 H), 7.48-7.75 (m, 3 H), 7.16-7.27 (m, 1 H), 6.76-7.03 (m, 2 H), 6.53-6.71 (m, 1 H), 6.35 (br s, 1 H), 4.04-4.19 (m, 1 H), 3.93 (s, 3 H), 3.61-3.79 (m, 1 H), 2.98 (br s, 1 H), 2.66-2.87 (m, 1 H) 348.1 [M+H] + 100%
661 (CD 3OD) δ 8.42-8.61 (m, 1 H), 7.47-7.75 (m, 3 H), 7.16-7.28 (m, 1 H), 6.76-7.03 (m, 2 H), 6.52-6.72 (m, 1 H), 6.34 (br s, 1 H), 4.03-4.20 (m, 1 H), 3.93 (s, 3 H), 3.59-3.78 (m, 1 H), 2.98 (br s, 1 H), 2.76 (br d, 1 H) 348.1 [M+H] + 96.8%
662 (CD 3OD) δ 8.30-8.64 (m, 1.5 H), 7.97 (br s, 0.5 H), 7.45-7.75 (m, 2 H), 7.14-7.23 (m, 1 H), 6.75-7.03 (m, 2.6 H), 6.17-6.64 (m, 1.4 H), 4.02-4.16 (m, 1 H), 3.96 (s, 3 H), 3.34-3.80 (m, 1 H), 2.93 (br t, 1 H), 2.70 (br dd, 1 H) 398.1 [M+H] + 100%
663 (CD 3OD) δ 8.25-8.66 (m, 1.5 H), 7.97 (br s, 0.5 H), 7.50-7.70 (m, 2 H), 7.12-7.27 (m, 1 H), 6.70-7.08 (m, 2.5 H), 6.08-6.69 (m, 1.5 H), 4.01-4.19 (m, 1 H), 3.96 (s, 3 H), 3.34-3.80 (m, 1 H), 2.93 (br t, 1 H), 2.60-2.77 (m, 1 H) 398.1 [M+H] + 99.3%
664 (CD 3OD) δ 8.17-8.60 (m, 1.5 H), 7.90 (br s, 0.5 H), 7.50-7.69 (m, 2 H), 7.18 (ddd, 1 H), 6.78-7.02 (m, 1.6 H), 6.12-6.68 (m, 1.4 H), 4.81 (br s, 0.5 H), 4.05 (br d, 0.5 H), 3.88 (s, 3 H), 3.71 (br s, 0.5 H), 3.15-3.30 (m, 0.5 H), 2.90-3.01 (m, 1 H), 2.72 (br dd, 1 H) 382.2 [M+H] + 100%
665 (CD 3OD) δ 8.19-8.58 (m, 1.5 H), 7.90 (br s, 0.5 H), 7.50-7.69 (m, 2 H), 7.17 (dd, 1 H), 6.78-7.01 (m, 1.6 H), 6.14-6.66 (m, 1.4 H), 4.69-4.83 (m, 0.6 H), 4.04 (br d, 0.4 H), 3.87 (s, 3 H), 3.69 (br s, 0.5 H), 3.24 (br s, 0.5 H), 2.88-3.00 (m, 1 H), 2.71 (br dd, 1 H) 382.2 [M+H] + 99.6%
666 (CD 3OD) δ 8.34-8.49 (m, 2 H), 7.52-7.86 (m, 3.3 H), 7.15-7.29 (m, 2 H), 6.83-7.00 (m, 1.7 H), 6.57-6.70 (m, 1 H), 5.03 (dd, 1 H), 3.72-3.86 (m, 0.7 H), 3.38-3.51 (m, 0.3 H), 2.96-3.27 (m, 1 H), 2.79-2.93 (m, 1 H) 452.2 [M+H] + 100%
667 (CD 3OD) δ 8.32-8.51 (m, 2 H), 7.53-7.85 (m, 3.5 H), 7.14-7.26 (m, 2 H), 6.81-7.01 (m, 1.5 H), 6.58-6.69 (m, 1 H), 5.03 (dd, 1 H), 3.80 (ddd, 0.7 H), 3.43 (td, 0.3 H), 2.97-3.27 (m, 1 H), 2.86 (br dd, 1 H) 452.3 [M+H] + 97.2%
668 (CD 3OD) δ 9.04 (d, 1 H), 8.55 (s, 1 H), 8.37-8.49 (m, 1 H), 7.96 (d, 1 H), 7.67-7.74 (m, 1 H), 7.51-7.64 (m, 1.3 H), 7.15-7.24 (m, 1 H), 6.98 (s, 0.7 H), 6.80-6.90 (m, 1 H), 6.58-6.69 (m, 1 H), 5.03 (dd, 1 H), 3.81 (ddd, 0.7 H), 3.39-3.50 (m, 0.4 H), 3.11-3.23 (m, 0.6 H), 2.97-3.07 (m, 0.4 H), 2.78-2.92 (m, 1 H) 481.1 [M+H] + 100%
669 (CD 3OD) δ 9.04 (d, 1 H), 8.55 (s, 1 H), 8.37-8.50 (m, 1 H), 7.96 (d, 1 H), 7.70 (s, 1 H), 7.50-7.63 (m, 1.3 H), 7.14-7.25 (m, 1 H), 6.98 (s, 0.7 H), 6.80-6.90 (m, 1 H), 6.58-6.69 (m, 1 H), 5.02 (br dd, 1 H), 3.76-3.85 (m, 0.7 H), 3.40-3.49 (m, 0.3 H), 3.16-3.25 (m, 0.7 H), 2.97-3.07 (m, 0.3 H), 2.78-2.90 (m, 1 H) 481.1 [M+H]+ 98.4%
670 (CD 3OD) δ 8.34 (d, 1 H), 7.37-7.67 (m, 2 H), 6.99-7.19 (m, 2 H), 6.68-6.93 (m, 2 H), 6.51 (s, 1 H), 4.22 (br d, 1 H), 3.26-3.80 (m, 1 H), 2.59-3.10 (m, 2 H), 1.45-1.66 (m, 6 H) 443.2 [M+H] + 100%
671 (CD 3OD) δ 8.33 (br d, 1 H), 7.41-7.71 (m, 2 H), 6.99-7.19 (m, 2 H), 6.71-6.94 (m, 2 H), 6.51 (s, 1 H), 4.23 (br d, 1 H), 3.28-3.78 (m, 1 H), 2.58-3.11 (m, 2 H), 1.42-1.67 (m, 6 H) 443.1 [M+H] + 98.9%
672 (CD 3OD) δ 8.59 (s, 1 H), 8.32-8.50 (m, 1 H), 8.07-8.24 (m, 1 H), 7.80-7.95 (m, 1 H), 7.67 (s, 1 H), 7.43-7.62 (m, 1.4 H), 7.10-7.24 (m, 1 H), 6.94 (s, 0.6 H), 6.74-6.89 (m, 1 H), 6.49-6.68 (m, 1 H), 4.97 (br dd, 1 H), 3.67-3.86 (m, 0.7 H), 3.39 (td, 0.3 H), 3.17 (br s, 0.7 H), 2.91-3.04 (m, 0.3 H), 2.82 (br d, 1 H), 2.45 (s, 3 H) 427.1 [M+H] + 100%
673 (CD 3OD) δ 8.59 (s, 1 H), 8.30-8.48 (m, 1 H), 8.09-8.22 (m, 1 H), 7.83-7.93 (m, 1 H), 7.67 (s, 1 H), 7.42-7.63 (m, 1.4 H), 7.09-7.25 (m, 1 H), 6.94 (s, 0.6 H), 6.72-6.88 (m, 1 H), 6.49-6.68 (m, 1 H), 4.97 (br dd, 1 H), 3.77 (ddd, 0.7 H), 3.39 (td, 0.3 H), 3.10-3.23 (m, 0.7 H), 2.91-3.06 (m, 0.3 H), 2.82 (br dd, 1 H), 2.45 (s, 3 H) 427.1 [M+H] + 98.3%
674 (CD 3OD) δ 8.82-9.33 (m, 1 H), 8.35-8.61 (m, 2 H), 7.88-8.02 (m, 2 H), 7.51-7.72 (m, 2 H), 7.37 (br t, 1 H), 7.20 (dd, 1 H), 6.58-7.05 (m, 2 H), 6.22-6.39 (m, 1 H), 4.10 (br d, 1 H), 3.76 (br s, 1 H), 3.00 (br s, 1 H), 2.76 (br d, 1 H) 445.2 [M+H] + 100%
675 (CD 3OD) δ 8.81-9.31 (m, 1 H), 8.40-8.59 (m, 2 H), 7.90-8.01 (m, 2 H), 7.52-7.70 (m, 2 H), 7.37 (br t, 1 H), 7.20 (dd, 1 H), 6.61-7.04 (m, 2 H), 6.23-6.38 (m, 1 H), 4.10 (br d, 1 H), 3.76 (br s, 1 H), 3.00 (br t, 1 H), 2.75 (br d, 1 H) 445.2 [M+H] + 99.6%
676 (CD 3OD) δ 8.46 (d, 1 H), 7.68 (s, 1 H), 7.61 (br d, 1 H), 7.13-7.30 (m, 1 H), 6.87 (td, 1.3 Hz, 1.7 H), 6.48-6.73 (m, 1 H), 6.39 (br s, 0.3 H), 4.78 (br s, 0.3 H), 4.16 (br d, 0.7 H), 3.69-3.91 (m, 0.7 H), 3.42 (br s, 0.3 H), 2.92-3.24 (m, 1 H), 2.82 (br d, 1 H), 1.53-1.70 (m, 6 H) 471.0 [M+H] + 100%
677 (CD 3OD) δ 8.46 (d, 1 H), 7.68 (s, 1 H), 7.62 (br d, 1 H), 7.13-7.28 (m, 1 H), 6.87 (td, 1.6 H), 6.49-6.72 (m, 1 H), 6.38 (br s, 0.4 H), 4.79 (br s, 0.3 H), 4.16 (br d, 0.7 H), 3.70-3.88 (m, 0.7 H), 3.42 (br s, 0.3 H), 3.12 (br d, 1 H), 2.82 (br d, 1 H), 1.52-1.72 (m, 6 H) 471.0 [M+H] + 99.7%
678 (CD 3OD) δ 8.58 (s, 1 H), 8.36-8.50 (m, 1 H), 7.71 (s, 1 H), 7.49-7.65 (m, 1.3 H), 7.15-7.27 (m, 1 H), 6.80-7.02 (m, 1.7 H), 6.53-6.68 (m, 1 H), 4.99 (br dd, 1 H), 4.07 (s, 3 H), 3.72-3.85 (m, 0.7 H), 3.41 (td, 0.3 H), 3.13-3.26 (m, 0.7 H), 2.93-3.09 (m, 0.3 H), 2.77-2.92 (m, 1 H) 484.1 [M+H] + 100%
679 (CD 3OD) δ 8.58 (s, 1 H), 8.37-8.54 (m, 1 H), 7.71 (s, 1 H), 7.47-7.65 (m, 1.3 H), 7.14-7.27 (m, 1 H), 6.78-7.01 (m, 1.7 H), 6.52-6.71 (m, 1 H), 4.99 (br dd, 1 H), 4.07 (s, 3 H), 3.73-3.84 (m, 0.7 H), 3.37-3.45 (m, 0.3 H), 3.12-3.26 (m, 0.7 H), 2.94-3.07 (m, 0.3 H), 2.77-2.91 (m, 1 H) 484.1 [M+H] + 100%
680 (CD 3OD) δ 8.40-8.59 (m, 1 H), 7.50-7.71 (m, 2 H), 7.19 (ddd, 1 H), 6.74-7.01 (m, 2 H), 6.45-6.69 (m, 1 H), 6.31 (br d, 1 H), 4.80 (br s, 0.4 H), 3.98-4.14 (m, 0.6 H), 3.81-3.89 (m, 3 H), 3.61-3.78 (m, 0.7 H), 3.29 (br s, 0.3 H), 2.90-3.04 (m, 1 H), 2.75 (br d, 1 H) 382.2 [M+H] + 100%
681 (CD 3OD) δ 8.40-8.59 (m, 1 H), 7.51-7.72 (m, 2 H), 7.19 (ddd, 1 H), 6.72-7.00 (m, 2 H), 6.47-6.67 (m, 1 H), 6.31 (br d, 1 H), 4.81 (br s, 0.5 H), 4.00-4.13 (m, 0.5 H), 3.85 (s, 3 H), 3.62-3.77 (m, 0.6 H), 3.25 (br s, 0.4 H), 2.89-3.03 (m, 1 H), 2.75 (br d, 1 H) 382.2 [M+H] + 99.2%
682 (CD 3OD) δ 8.44-8.71 (m, 2 H), 7.68 (s, 1 H), 7.53 (br d, 1 H), 7.26 (dd, 1 H), 6.45-6.88 (m, 2 H), 4.39 (br d, 1 H), 3.35-3.94 (m, 1 H), 2.73-3.20 (m, 2 H) 440.1 [M+H] + 100%
683 (CD 3OD) δ 8.37-8.78 (m, 2 H), 7.68 (s, 1 H), 7.55 (br d, 1 H), 7.27 (dd, 1 H), 6.37-6.93 (m, 2 H), 4.39 (br d, 1 H), 3.34-3.94 (m, 1 H), 2.73-3.23 (m, 2 H) 440.1 [M+H] + 99.8%
684 (CD 3OD) δ 8.40-8.62 (m, 2 H), 7.52-7.72 (m, 2 H), 7.19 (dd, 1 H), 6.52-6.90 (m, 2 H), 4.38 (br d, 1 H), 3.33-3.92 (m, 1 H), 2.72-3.22 (m, 2 H) 394.0 [M+H] + 100%
685 (CD 3OD) δ 8.40-8.62 (m, 2 H), 7.52-7.76 (m, 2 H), 7.20 (dd, 1 H), 6.46-6.91 (m, 2 H), 4.39 (br d, 1 H), 3.35-3.90 (m, 1 H), 3.11 (br s, 1 H), 2.72-2.95 (m, 1 H) 394.0 [M+H] + 99.8%
686 (CD 3OD) δ 8.38-8.54 (m, 2 H), 7.62-7.79 (m, 1 H), 7.30 (d, 1 H), 6.48-7.00 (m, 3 H), 4.40 (br d, 1 H), 3.77 (br s, 1 H), 2.77-3.19 (m, 2 H) 394.2 [M+H] + 98.6%
687 (CD 3OD) δ 8.39-8.56 (m, 2 H), 7.69 (s, 1 H), 7.30 (d, 1 H), 6.46-6.94 (m, 3 H), 4.41 (br d, 1 H), 3.78 (br d, 1 H), 2.77-3.20 (m, 2 H) 394.2 [M+H] + 94.5%
688 (CD 3OD) δ 8.33-8.48 (m, 2 H), 7.98-8.17 (m, 1 H), 7.53-7.72 (m, 1.3 H), 7.21-7.36 (m, 1 H), 6.60-7.03 (m, 2.7 H), 4.92-5.10 (m, 1 H), 4.00 (s, 3 H), 3.76 (ddd, 0.6 H), 3.35-3.44 (m, 0.4 H), 2.92-3.22 (m, 1 H), 2.79-2.89 (m, 1 H) 450.2 [M+H] + 100%
689 (CD 3OD) δ 8.35-8.49 (m, 2 H), 8.04-8.16 (m, 1 H), 7.50-7.74 (m, 1.3 H), 7.24-7.35 (m, 1 H), 6.68-6.97 (m, 2.7 H), 4.92-5.12 (m, 1 H), 4.00 (s, 3 H), 3.71-3.83 (m, 0.7 H), 3.40 (td, 0.3 H), 2.93-3.23 (m, 1 H), 2.77-2.90 (m, 1 H) 450.2 [M+H] + 99.3%
690 (CD 3OD) δ 8.44 (br d, 1 H), 7.54-7.70 (m, 2 H), 7.10-7.28 (m, 2 H), 6.81-7.01 (m, 2 H), 6.60 (br s, 1 H), 4.94-5.00 (m, 1 H), 4.33 (br d, 1 H), 3.72 (br s, 1 H), 2.92-3.20 (m, 1 H), 2.80 (br d, 1 H), 1.61 (br d, 3 H) 429.3 [M+H] + 99.6%
691 (CD 3OD) δ 8.44 (br d, 1 H), 7.53-7.71 (m, 2 H), 7.10-7.29 (m, 2 H), 6.79-7.02 (m, 2 H), 6.60 (s, 1 H), 4.94-5.01 (m, 1 H), 4.34 (br d, 1 H), 3.73 (br s, 1 H), 2.90-3.19 (m, 1 H), 2.81 (br d, 1 H), 1.50-1.68 (m, 3 H) 429.2 [M+H] + 99.7%
692 (CD 3OD) δ 8.44 (br d, 1 H), 7.68 (s, 1 H), 7.59 (br d, 1 H), 7.27 (s, 0.2 H), 7.16-7.23 (m, 1 H), 6.97-7.14 (m, 0.8 H), 6.85 (br t, 2 H), 6.61 (s, 1 H), 4.97 (br d, 1 H), 4.35 (br d, 1 H), 3.63-3.80 (m, 0.7 H), 3.37-3.49 (m, 0.3 H), 2.91-3.20 (m, 1 H), 2.81 (br d, 1 H), 1.60 (br d, 3 H) 429.2 [M+H] + 100%
693 (CD 3OD) δ 8.44 (br d, 1 H), 7.68 (s, 1 H), 7.59 (br d, 1 H), 7.26 (s, 0.2 H), 7.16-7.22 (m, 1 H), 6.98-7.14 (m, 0.8 H), 6.86 (br t, 2 H), 6.61 (s, 1 H), 4.97 (br d, 1 H), 4.34 (br d, 1 H), 3.72 (br s, 0.7 H), 3.48 (br s, 0.4 H), 2.89-3.19 (m, 1 H), 2.81 (br d, 1 H), 1.61 (br d, 3 H) 429.2 [M+H] + 100%
694 (CD 3OD) δ 8.40-8.48 (m, 1 H), 7.65-7.70 (m, 1 H), 7.51-7.61 (m, 1 H), 7.13-7.24 (m, 1 H), 6.80-6.94 (m, 2 H), 6.35-6.64 (m, 1 H), 4.83 (br s, 0.3, 4.44 (dd, 0.7 H), 4.02 (s, 3 H), 3.59-3.73 (m, 0.7 H), 3.09-3.27 (m, 1 H), 2.90-3.01 (m, 0.3 H), 2.70-2.85 (m, 1 H) 383.2 [M+H] + 99.0%
695 (CD 3OD) δ 8.40-8.48 (m, 1 H), 7.65-7.71 (m, 1 H), 7.50-7.61 (m, 1 H), 7.13-7.23 (m, 1 H), 6.79-6.93 (m, 2 H), 6.34-6.63 (m, 1 H), 4.83 (br s, 0.3, 4.44 (dd, 0.7 H), 4.02 (s, 3 H), 3.66 (ddd, 0.7 H), 3.08-3.27 (m, 1 H), 2.90-3.00 (m, 0.3 H), 2.70-2.85 (m, 1 H) 383.2 [M+H] + 98.6%
696 (CD 3OD) δ 8.49-8.63 (m, 1 H), 8.32 (br s, 1 H), 8.08 (s, 1 H), 7.53-7.70 (m, 2.3 H), 7.08-7.27 (m, 1 H), 6.91 (s, 0.7 H), 6.58-6.73 (m, 1 H), 5.07 (br dd, 0.5 H), 3.99 (s, 3 H), 3.66-3.85 (m, 1 H), 3.39 (td, 0.5 H), 2.73-3.24 (m, 2 H) 450.2 [M+H] + 100%
697 (CD 3OD) δ 8.50-8.62 (m, 1 H), 8.38 (s, 1 H), 8.03-8.15 (m, 1 H), 7.51-7.74 (m, 2.4 H), 7.13-7.30 (m, 1 H), 6.92 (s, 0.6 H), 6.60-6.73 (m, 1 H), 5.07 (br dd, 0.5 H), 4.00 (s, 3 H), 3.67-3.83 (m, 1 H), 3.33-3.48 (m, 0.5 H), 2.72-3.23 (m, 2 H) 450.2 [M+H] + 99.7%
698 (CD 3OD) δ 8.35 (d, 1 H), 7.38-7.71 (m, 2 H), 6.86-7.29 (m, 2 H), 6.38-6.81 (m, 3 H), 4.21 (br d, 1 H), 3.29-3.78 (m, 1 H), 2.58-3.15 (m, 2 H), 1.54-1.90 (m, 6 H) 452.2 [M+H] + 98.3%
699 (CD 3OD) δ 8.47 (d, 1 H), 7.52-7.79 (m, 2 H), 6.99-7.36 (m, 2 H), 6.45-6.93 (m, 3 H), 4.33 (br d, 1 H), 3.38-3.85 (m, 1 H), 2.69-3.27 (m, 2 H), 1.67-2.01 (m, 6 H)) 452.2 [M+H] + 98.4%
700 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 6.94-7.35 (m, 2 H), 6.51-6.93 (m, 3 H), 4.36 (br d, 1 H), 3.33-3.82 (m, 1 H), 2.70-3.18 (m, 2 H), 1.54-1.73 (m, 6 H) 477.2 [M+H] + 94.7%
701 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 6.94-7.38 (m, 2 H), 6.51-6.93 (m, 3 H), 4.35 (br d, 1 H), 3.37-3.88 (m, 1 H), 2.73-3.23 (m, 2 H), 1.55-1.74 (m, 6 H) 477.2 [M+H] + 99.4%
702 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.94-7.27 (m, 1 H), 6.85 (t, 1.7 H), 6.49-6.77 (m, 1.3 H), 4.97 (br d, 1.3 H), 4.36 (br d, 0.7 H), 3.36-3.85 (m, 1 H), 2.73-3.23 (m, 2 H), 1.49-1.71 (m, 3 H) 463.0 [M+H] + 98.1%
703 (CD 3OD) δ 8.43 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.97-7.27 (m, 1 H), 6.85 (t, 1.6 H), 6.54-6.78 (m, 1.4 H), 4.97 (br d, 1.3 H), 4.37 (br d, 0.7 H), 3.37-3.81 (m, 1 H), 2.75-3.21 (m, 2 H), 1.46-1.67 (m, 3 H) 463.0 [M+H] + 96.7%
704 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.95-7.27 (m, 1 H), 6.85 (t, 1.6 H), 6.54-6.77 (m, 1.4 H), 4.40 (br d, 1 H), 3.36-3.83 (m, 1 H), 2.70-3.21 (m, 2 H), 1.20-1.46 (m, 4 H) 475.2 [M+H] + 98.7%
705 (CD 3OD) δ 8.44 (d, 1 H), 7.72 (br s, 1 H), 7.30 (d, 1 H), 6.95-7.27 (m, 1 H), 6.85 (t, 1.6 H), 6.74 (s, 1.4 H), 4.41 (br d, 1 H), 3.72 (br s, 1 H), 2.73-3.23 (m, 2 H), 1.23-1.44 (m, 4 H) 475.1 [M+H] + 99.2%
706 (CD 3OD) δ 8.43 (d, 1 H), 7.67 (s, 1 H), 7.29 (d, 1 H), 6.34-6.98 (m, 3 H), 4.91 (br s, 1 H), 4.28-4.79 (m, 1 H), 3.37-3.83 (m, 1 H), 2.68-3.20 (m, 2 H), 2.37 (s, 3 H), 1.55 (br s, 3 H) 427.2 [M+H] + 98.7%
707 (CD 3OD) δ 8.43 (d, 1 H), 7.66 (s, 1 H), 7.28 (d, 1 H), 6.41-6.93 (m, 3 H), 4.88-4.94 (m, 1 H), 4.36 (br s, 1 H), 3.39-3.79 (m, 1 H), 2.68-3.21 (m, 2 H), 2.37 (s, 3 H), 1.55 (br s, 3 H) 427.2 [M+H] + 97.7%
708 (CD 3OD) δ 8.43 (d, 1 H), 7.66 (s, 1 H), 7.28 (d, 1 H), 6.41-6.93 (m, 3 H), 4.88-4.94 (m, 1 H), 4.36 (br s, 1 H), 3.39-3.79 (m, 1 H), 2.68-3.21 (m, 2 H), 2.37 (s, 3 H), 1.55 (br s, 3 H) 427.2 [M+H] + 97.7%
709 (CD 3OD) δ 8.43 (d, 1 H), 7.67 (s, 1 H), 7.29 (d, 1 H), 6.32-6.97 (m, 3 H), 4.89-4.93 (m, 1 H), 4.34 (br s, 1 H), 3.37-3.83 (m, 1 H), 2.68-3.23 (m, 2 H), 2.37 (s, 3 H), 1.56 (br s, 3 H) 427.2 [M+H] + 99.5%
710 (CD 3OD) δ 8.33 (d, 1 H), 7.67 (s, 1 H), 6.91-7.29 (m, 2 H), 6.49-6.90 (m, 3 H), 4.97 (br d, 1.3 H), 4.36 (br d, 0.7 H), 3.34-3.80 (m, 1 H), 2.70-3.21 (m, 2 H), 1.49-1.68 (m, 3 H) 447.1 [M+H] + 98.9%
711 (CD 3OD) δ 8.33 (d, 1 H), 7.67 (s, 1 H), 6.92-7.31 (m, 2 H), 6.51-6.90 (m, 3 H), 4.97 (br d, 1.4 H), 4.36 (br d, 0.6 H), 3.37-3.85 (m, 1 H), 2.68-3.21 (m, 2 H), 1.46-1.67 (m, 3 H) 447.1 [M+H] + 99.5%
712 (CD 3OD) δ 8.33 (d, 1 H), 7.61-7.72 (m, 1 H), 6.93-7.31 (m, 2 H), 6.52-6.90 (m, 3 H), 4.97 (br d, 1 H), 4.36 (br d, 1 H), 3.37-3.80 (m, 1 H), 2.72-3.21 (m, 2 H), 1.61 (br d, 3 H) 447.1 [M+H] + 95.9%
713 (CD 3OD) δ 8.33 (d, 1 H), 7.62-7.74 (m, 1 H), 6.91-7.30 (m, 2 H), 6.48-6.90 (m, 3 H), 4.97 (br d, 1 H), 4.30-4.45 (m, 1 H), 3.36-3.80 (m, 1 H), 2.72-3.22 (m, 2 H), 1.48-1.69 (m, 3 H) 447.1 [M+H] + 98.8%
714 (CD 3OD) δ 8.33 (d, 1 H), 7.67 (s, 1 H), 6.90-7.28 (m, 2 H), 6.49-6.89 (m, 3 H), 4.33 (br s, 1 H), 3.37-3.86 (m, 1 H), 2.74-3.20 (m, 2 H), 1.66 (br s, 6 H) 461.1 [M+H] + 99.7%
715 (CD 3OD) δ 8.33 (d, 1 H), 7.67 (s, 1 H), 6.90-7.30 (m, 2 H), 6.50-6.89 (m, 3 H), 4.34 (br d, 1 H), 3.36-3.84 (m, 1 H), 2.73-3.22 (m, 2 H), 1.56-1.71 (m, 6 H) 461.1 [M+H] + 99.6%
716 (CD 3OD) δ 8.40-8.57 (m, 1 H), 7.89 (br s, 1 H), 7.51-7.75 (m, 2 H), 7.17-7.30 (m, 1 H), 6.84-7.06 (m, 2 H), 6.58-6.80 (m, 1 H), 5.92-6.41 (m, 1 H), 4.85 (br d, 0.4 H), 3.70-3.83 (m, 1.2 H), 3.36-3.45 (m, 0.4 H), 2.67-3.09 (m, 2 H) 402.20 [M+H] + 100%
717 (CD 3OD) δ 8.41-8.59 (m, 1 H), 7.89 (br s, 1 H), 7.49-7.79 (m, 2 H), 7.14-7.30 (m, 1 H), 6.85-7.04 (m, 2 H), 6.59-6.82 (m, 1 H), 5.96-6.42 (m, 1 H), 4.85 (br d, 0.4 H), 3.69-3.83 (m, 1.2 H), 3.36-3.46 (m, 0.4 H), 2.64-3.04 (m, 2 H) 402.20 [M+H] + 100%
718 (CD 3OD) δ 8.36-8.50 (m, 2 H), 8.05-8.18 (m, 1 H), 7.53-7.76 (m, 1.3 H), 7.24-7.35 (m, 1 H), 6.92 (s, 0.7 H), 6.65-6.88 (m, 2 H), 5.07 (br dd, 1 H), 3.98 (s, 3 H), 3.67-3.82 (m, 0.7 H), 3.32-3.45 (m, 0.3 H), 2.92-3.21 (m, 1 H), 2.78-2.89 (m, 1 H) 450.1 [M+H] + 100%
719 (CD 3OD) δ 8.32-8.47 (m, 2 H), 8.09 (d, 1 H), 7.73-7.87 (m, 1 H), 7.22-7.61 (m, 1.3 H), 6.95 (s, 0.7 H), 6.67-6.89 (m, 2 H), 5.08 (br dd, 1 H), 3.98 (s, 3 H), 3.66-3.79 (m, 0.6 H), 3.33-3.42 (m, 0.4 H), 2.93-3.22 (m, 1 H), 2.84 (br d, 1 H) 450.0 [M+H] + 99.0%
720 (CD 3OD) δ 8.46 (d, 1 H), 7.70 (s, 1 H), 7.32 (d, 1 H), 6.82-7.00 (m, 1.7 H), 6.76 (br s, 1 H), 6.45 (br s, 0.3 H), 4.82 (br s, 0.4 H), 4.24 (br d, 0.6 H), 3.68-3.91 (m, 0.6 H), 3.41 (br s, 0.4 H), 2.92-3.25 (m, 1 H), 2.70-2.91 (m, 1 H), 1.51-1.70 (m, 6 H) 461.2 [M+H] + 100%
721 (CD 3OD) δ 8.46 (d, 1 H), 7.70 (s, 1 H), 7.31 (d, 1 H), 6.81-6.93 (m, 1.7 H), 6.76 (br s, 1 H), 6.45 (br s, 0.3 H), 4.79 (br s, 0.3 H), 4.24 (br d, 0.7 H), 3.78 (br t, 0.7 H), 3.41 (br s, 0.3 H), 3.15 (br s, 1 H), 2.84 (br d, 1 H), 1.52-1.72 (m, 6 H) 461.1 [M+H] + 100%
722 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.84 (t, 1.6 H), 6.25-6.76 (m, 1.4 H), 4.79 (br s, 0.4 H), 4.17 (br d, 0.6 H), 3.36-3.84 (m, 1 H), 2.75-3.23 (m, 2 H), 1.49-1.69 (m, 6 H) 507.1 [M+H] + 96.2%
723 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.84 (t, 1.6 H), 6.31-6.76 (m, 1.4 H), 4.82 (br s, 0.4 H), 4.17 (br d, 0.6 H), 3.36-3.83 (m, 1 H), 2.75-3.22 (m, 2 H), 1.52-1.71 (m, 6 H) 507.2 [M+H] + 98.3%
724 (CD 3OD) δ 8.43 (d, 1 H), 7.56-7.74 (m, 1 H), 7.29 (d, 1 H), 6.42-6.93 (m, 3 H), 4.24-4.44 (m, 1 H), 3.39-3.80 (m, 1 H), 2.70-3.23 (m, 2 H), 2.37 (s, 3 H), 1.62 (br s, 6 H) 441.3 [M+H] + 98.3%
725 (CD 3OD) δ 8.44 (d, 1 H), 7.67 (s, 1 H), 7.29 (d, 1 H), 6.43-6.95 (m, 3 H), 4.35 (br s, 1 H), 3.38-3.80 (m, 1 H), 2.73-3.22 (m, 2 H), 2.37 (s, 3 H), 1.62 (br s, 6 H) 441.3 [M+H] + 99.8%
726 (CD 3OD) δ 8.33 (d, 1 H), 7.66 (s, 1 H), 6.95 (dd, 1 H), 6.46-6.89 (m, 3 H), 4.89 (br d, 1 H), 4.35 (br s, 1 H), 3.38-3.80 (m, 1 H), 2.70-3.20 (m, 2 H), 2.36 (s, 3 H), 1.56 (br s, 3 H) 411.2 [M+H] 98.4%
727 (CD 3OD) δ 8.33 (d, 1 H), 7.66 (s, 1 H), 6.95 (dd, 1 H), 6.42-6.90 (m, 3 H), 4.90 (br d, 1 H), 4.36 (br s, 1 H), 3.36-3.79 (m, 1 H), 2.70-3.20 (m, 2 H), 2.37 (s, 3 H), 1.55 (br s, 3 H) 411.2 [M+H] 99.9%
728 (CD 3OD) δ 8.25-8.46 (m, 2 H), 8.10 (s, 1 H), 7.56-7.73 (m, 1.3 H), 6.92-7.00 (m, 1.7 H), 6.68-6.89 (m, 2 H), 5.09 (br dd, 1 H), 4.00 (s, 3 H), 3.70-3.83 (m, 0.7 H), 3.40 (td, 0.3 H), 2.93-3.22 (m, 1 H), 2.79-2.89 (m, 1 H) 434.1 [M+H] + 99.8%
729 (CD 3OD) δ 8.26-8.42 (m, 2 H), 8.10 (s, 1 H), 7.56-7.72 (m, 1.3 H), 6.92-7.00 (m, 1.7 H), 6.68-6.89 (m, 2 H), 5.09 (br dd, 1 H), 4.00 (s, 3 H), 3.70-3.84 (m, 0.7 H), 3.40 (td, 0.3 H), 2.93-3.22 (m, 1 H), 2.77-2.90 (m, 1 H) 434.1 [M+H] + 97.8%
730 (CD 3OD) δ 8.24-8.40 (m, 1 H), 7.81 (d, 1 H), 7.70 (s, 1 H), 7.51 (s, 0.3 H), 6.90-7.03 (m, 2.7 H), 6.71-6.88 (m, 2 H), 5.04 (br dd, 1 H), 4.03 (s, 3 H), 3.78 (ddd, 0.6 H), 3.37-3.45 (m, 0.4 H), 2.79-3.24 (m, 2 H) 434.2 [M+H] + 100%
731 (CD 3OD) δ 8.25-8.39 (m, 1 H), 7.81 (d, 1 H), 7.69 (s, 1 H), 7.51 (br s, 0.3 H), 6.91-7.02 (m, 2.7 H), 6.72-6.88 (m, 2 H), 4.96-5.10 (m, 1 H), 4.03 (s, 3 H), 3.73-3.83 (m, 0.6 H), 3.38-3.45 (m, 0.4 H), 2.80-3.23 (m, 2 H) 434.3 [M+H] + 99.8%
732 (CD 3OD) δ 8.78 (d, 1 H), 8.25-8.42 (m, 2 H), 8.02-8.16 (m, 1 H), 7.43-7.77 (m, 2.3 H), 6.90-7.06 (m, 1.7 H), 6.73-6.90 (m, 2 H), 4.93-5.08 (m, 1 H), 3.74-3.87 (m, 0.7 H), 3.43 (td, 0.3 H), 2.82-3.26 (m, 2 H) 431.3 [M+H] + 98.9%
733 (CD 3OD) δ 8.78 (d, 1 H), 8.22-8.42 (m, 2 H), 8.08 (td, 1 H), 7.43-7.76 (m, 2.3 H), 6.91-7.03 (m, 1.7 H), 6.74-6.88 (m, 2 H), 4.93-5.06 (m, 1 H), 3.74-3.86 (m, 0.7 H), 3.38-3.50 (m, 0.3 H), 2.81-3.25 (m, 2 H) 431.2 [M+H] + 99.8%
734 (CD 3OD) δ 8.78 (dd, 1 H), 8.36-8.49 (m, 1 H), 8.31 (dd, 1 H), 8.08 (td, 1 H), 7.60-7.75 (m, 2 H), 7.49 (br s, 0.3 H), 7.23-7.38 (m, 1 H), 6.97 (s, 0.7 H), 6.69-6.90 (m, 2 H), 4.95-5.08 (m, 1 H), 3.79 (ddd, 0.7 H), 3.37-3.51 (m, 0.3 H), 2.78-3.24 (m, 2 H) 447.3 [M+H] + 99.6%
735 (CD 3OD) δ 8.77 (d, 1 H), 8.35-8.50 (m, 1 H), 8.31 (d, 1 H), 8.08 (td, 1 H), 7.62-7.76 (m, 2 H), 7.49 (br s, 0.3 H), 7.23-7.37 (m, 1 H), 6.97 (br s, 0.7 H), 6.71-6.88 (m, 2 H), 4.95-5.06 (m, 1 H), 3.72-3.86 (m, 0.7 H), 3.38-3.49 (m, 0.3 H), 2.82-3.26 (m, 2 H) 447.3 [M+H] + 100%
736 (CD 3OD) δ 8.30 (d, 1 H), 7.69 (br s, 1 H), 7.11-7.30 (m, 1 H), 6.99 (br d, 1 H), 6.86 (br s, 1 H), 6.79 (t, 1 H), 6.52-6.70 (m, 1 H), 4.69-4.83 (m, 0.4 H), 4.25-4.40 (m, 0.6 H), 3.74 (br t, 0.6 H), 3.43 (br s, 0.4 H), 2.91-3.21 (m, 1 H), 2.83 (br d, 1 H), 2.45 (s, 3 H), 1.49-1.76 (m, 6 H) 457.4 [M+H] + 100%
737 (CD 3OD) δ 8.30 (d, 1 H), 7.68 (br s, 1 H), 7.10-7.30 (m, 1 H), 6.99 (br d, 1 H), 6.86 (br s, 1 H), 6.78 (t, 1 H), 6.53-6.70 (m, 1 H), 4.80 (br s, 0.2 H), 4.24-4.40 (m, 0.6 H), 3.65-3.83 (m, 0.6 H), 3.44 (br s, 0.4 H), 2.92-3.23 (m, 1 H), 2.82 (br d, 1 H), 2.44 (s, 3 H), 1.50-1.74 (m, 6 H) 457.4 [M+H] + 99.5%
738 (CD 3OD) δ 8.30 (br d, 1 H), 7.68 (s, 1 H), 7.09-7.31 (m, 1 H), 6.99 (br d, 1 H), 6.86 (br s, 1 H), 6.78 (t, 1 H), 6.61 (br s, 1 H), 4.97 (q, 1 H), 4.77 (br s, 0.3 H), 4.35 (br d, 0.6 H), 3.74 (br t, 0.6 H), 3.44 (br s, 0.3 H), 2.90-3.19 (m, 1 H), 2.81 (br d, 1 H), 2.44 (s, 3 H), 1.61 (br d, 3 H) 443.3 [M+H] + 99.6%
739 (CD 3OD) δ 8.30 (br d, 1 H), 7.68 (s, 1 H), 7.09-7.31 (m, 1 H), 6.99 (br d, 1 H), 6.86 (br s, 1 H), 6.78 (t, 1 H), 6.51-6.70 (m, 1 H), 4.97 (q, 1 H), 4.78 (br s, 0.1 H), 4.35 (br d, 0.6 H), 3.64-3.81 (m, 0.6 H), 3.46 (br d, 0.4 H), 2.91-3.19 (m, 1 H), 2.81 (br d, 1 H), 2.44 (s, 3 H), 1.60 (br d, 3 H) 443.3 [M+H] + 99.3%
740 (CD 3OD) δ 8.77 (d, 1 H), 8.20-8.36 (m, 2 H), 8.08 (td, 1 H), 7.60-7.75 (m, 2 H), 7.50 (s, 0.3 H), 6.92-7.04 (m, 1.7 H), 6.71-6.84 (m, 1 H), 6.57-6.68 (m, 1 H), 5.00 (br dd, 1 H), 3.74-3.86 (m, 0.6 H), 3.43 (td, 0.3 H), 2.96-3.26 (m, 1 H), 2.79-2.90 (m, 1 H), 2.39-2.49 (m, 3 H) 427.3 [M+H] + 99.6%
741 (CD 3OD) δ 8.77 (d, 1 H), 8.20-8.36 (m, 2 H), 8.08 (td, 1 H), 7.61-7.74 (m, 2 H), 7.50 (s, 0.3 H), 6.93-7.04 (m, 1.7 H), 6.72-6.83 (m, 1 H), 6.57-6.68 (m, 1 H), 5.00 (br dd, 1 H), 3.73-3.87 (m, 0.6 H), 3.43 (td, 0.4 H), 2.95-3.27 (m, 1 H), 2.85 (br d, 1 H), 2.39-2.48 (m, 3 H) 427.3 [M+H] + 100%
742 (CD 3OD) δ 8.20-8.34 (m, 1 H), 7.81 (d, 1 H), 7.69 (s, 1 H), 7.52 (s, 0.5 H), 6.91-7.03 (m, 2.5 H), 6.71-6.85 (m, 1 H), 6.52-6.66 (m, 1 H), 5.01 (br dd, 1 H), 4.02 (s, 3 H), 3.72-3.83 (m, 0.7 H), 3.41 (td, 0.4 H), 3.12-3.24 (m, 0.8 H), 2.93-3.06 (m, 0.4 H), 2.75-2.88 (m, 1 H), 2.35-2.48 (m, 3 H) 430.4 [M+H] + 100%
743 (CD 3OD) δ 8.21-8.35 (m, 1 H), 7.81 (s, 1 H), 7.69 (s, 1 H), 7.52 (s, 0.5 H), 6.93-7.02 (m, 2.5 H), 6.71-6.82 (m, 1 H), 6.53-6.66 (m, 1 H), 5.01 (br dd, 0.4 H), 4.03 (s, 3 H), 3.72-3.84 (m, 0.7 H), 3.35-3.46 (m, 1 H), 3.12-3.24 (m, 0.6 H), 2.94-3.06 (m, 0.4 H), 2.83 (br d, 1 H), 2.40-2.49 (m, 3 H) 430.4 [M+H] + 100%
744 (CD 3OD) δ 8.25-8.43 (m, 1 H), 7.55-7.78 (m, 1 H), 6.93-7.02 (m, 1 H), 6.79-6.92 (m, 1.7 H), 6.55-6.75 (m, 1 H), 6.05 (br s, 0.3 H), 4.81-4.87 (m, 0.3 H), 3.67-3.86 (m, 1.4 H), 3.45 (td, 0.3 H), 2.71-3.08 (m, 2 H), 1.54-1.71 (m, 6 H) 479.2 [M+H] 98.4%
745 (CD 3OD) δ 8.29-8.40 (m, 1 H), 7.63-7.73 (m, 1 H), 6.92-7.02 (m, 1 H), 6.78-6.91 (m, 1.7 H), 6.58-6.75 (m, 1 H), 6.04 (br s, 0.3 H), 4.81-4.87 (m, 0.2 H), 3.68-3.86 (m, 1.4 H), 3.45 (td, 0.4 H), 2.72-3.07 (m, 2 H), 1.53-1.71 (m, 6 H) 479.2 [M+H] 98.9%
746 (CD 3OD) δ 8.34 (d, 1 H), 7.67 (s, 1 H), 6.96 (dd, 1 H), 6.83 (td, 1.7 H), 6.63-6.78 (m, 1 H), 6.38 (br s, 0.3 H), 4.72-4.82 (m, 0.4 H), 4.16 (br d, 0.6 H), 3.37-3.84 (m, 1 H), 2.75-3.22 (m, 2 H), 1.52-1.66 (m, 6 H) 489.2 [M+H] 98.8%
747 (CD 3OD) δ 8.34 (d, 1 H), 7.67 (s, 1 H), 6.96 (dd, 1 H), 6.83 (td, 1.7 H), 6.64-6.78 (m, 1 H), 6.38 (br s, 0.3 H), 4.81 (br s, 0.4 H), 4.16 (br d, 0.6 H), 3.36-3.86 (m, 1 H), 2.75-3.20 (m, 2 H), 1.52-1.65 (m, 6 H) 489.1 [M+H] 99.7%
748 (CD 3OD) δ 8.39 (s, 1 H), 8.21-8.33 (m, 1 H), 8.10 (s, 1 H), 7.52-7.74 (m, 1 H), 6.92-7.03 (m, 2 H), 6.71-6.82 (m, 1 H), 6.53-6.65 (m, 1 H), 5.06 (dd, 1 H), 4.00 (s, 3 H), 3.70-3.85 (m, 0.7 H), 3.40 (td, 0.3 H), 3.10-3.23 (m, 0.7 H), 2.93-3.06 (m, 0.3 H), 2.78-2.88 (m, 1 H), 2.37-2.49 (m, 3 H) 430.3 [M+H] + 99.4%
749 (CD 3OD) δ 8.38 (s, 1 H), 8.20-8.34 (m, 1 H), 8.09 (s, 1 H), 7.54-7.73 (m, 1 H), 6.91-7.03 (m, 2 H), 6.70-6.82 (m, 1 H), 6.52-6.65 (m, 1 H), 5.06 (dd, 1 H), 4.00 (s, 3 H), 3.71-3.82 (m, 0.7 H), 3.40 (td, 0.3 H), 3.09-3.23 (m, 0.7 H), 2.91-3.04 (m, 0.3 H), 2.76-2.89 (m, 1 H), 2.36-2.49 (m, 3 H) 430.3 [M+H] + 98.6%
750 (CD 3OD) δ 8.29 (d, 1 H), 7.66 (s, 1 H), 6.98 (d, 1 H), 6.49-6.89 (m, 3 H), 4.90-4.94 (m, 1 H), 4.73 (br s, 0.3 H), 4.34 (br d, 0.7 H), 3.38-3.79 (m, 1 H), 3.09 (br s, 1 H), 2.79 (br d, 1 H), 2.44 (s, 3 H), 2.36 (s, 3 H), 1.55 (br s, 3 H) 407.3 [M+H] + 99.1%
751 (CD 3OD) δ 8.30 (d, 1 H), 7.66 (s, 1 H), 6.98 (d, 1 H), 6.72-6.89 (m, 1.7 H), 6.48-6.70 (m, 1.3 H), 4.89-4.93 (m, 1 H), 4.67-4.76 (m, 0.4 H), 4.32 (br s, 0.6 H), 3.39-3.81 (m, 1 H), 3.10 (br s, 1 H), 2.79 (br d, 1 H), 2.44 (s, 3 H), 2.36 (s, 3 H), 1.56 (br s, 3 H) 407.4 [M+H] + 99.4%
752 (CD 3OD) δ 8.29 (d, 1 H), 7.66 (s, 1 H), 6.98 (d, 1 H), 6.84 (br s, 0.6 H), 6.77 (t, 1 H), 6.48-6.70 (m, 1.4 H), 4.91-4.94 (m, 1 H), 4.72 (br s, 0.5 H), 4.34 (br s, 0.5 H), 3.54-3.81 (m, 1 H), 3.11 (br s, 1 H), 2.79 (br d, 1 H), 2.44 (s, 3 H), 2.36 (s, 3 H), 1.43-1.63 (m, 3 H) 407.3 [M+H] + 100%
753 (CD 3OD) δ 8.29 (d, 1 H), 7.66 (s, 1 H), 6.98 (d, 1 H), 6.84 (br s, 0.6 H), 6.77 (t, 1 H), 6.46-6.72 (m, 1.4 H), 4.90-4.94 (m, 1 H), 4.73 (br s, 0.4 H), 4.33 (br s, 0.6 H), 3.39-3.80 (m, 1 H), 3.10 (br s, 1 H), 2.79 (br d, 1 H), 2.44 (s, 3 H), 2.37 (s, 3 H), 1.55 (br s, 3 H) 407.4 [M+H] + 99.8%
754 (CD 3OD) δ 8.29 (d, 1 H), 7.75 (br s, 1 H), 6.98 (d, 1 H), 6.55-6.90 (m, 3 H), 4.60-4.78 (m, 0.5 H), 4.35 (br s, 0.5 H), 3.38-3.81 (m, 1 H), 3.12 (br d, 1 H), 2.80 (br d, 1 H), 2.32-2.50 (m, 6 H), 1.61 (br s, 6 H) 421.4 [M+H] + 100%
755 (CD 3OD) δ 8.29 (d, 1 H), 7.66 (s, 1 H), 6.97 (d, 1 H), 6.47-6.90 (m, 3 H), 4.63-4.77 (m, 0.5 H), 4.33 (br s, 0.5 H), 3.38-3.82 (m, 1 H), 3.11 (br s, 1 H), 2.79 (br d, 1 H), 2.33-2.48 (m, 6 H), 1.61 (br s, 6 H) 421.4 [M+H] + 99.8%
756 (CD 3OD) δ 8.34 (d, 1 H), 7.68 (s, 1 H), 6.96 (dd, 7.7 Hz, 1 H), 6.65-6.89 (m, 2.7 H), 6.43 (br s, 0.3 H), 4.15-4.82 (m, 1 H), 3.38-3.84 (m, 1 H), 2.79-3.18 (m, 2 H), 1.53-1.68 (m, 6 H) 445.3 [M+H] + 100%
757 (CD 3OD) δ 8.34 (d, 1 H), 7.68 (s, 1 H), 6.96 (dd, 1 H), 6.63-6.89 (m, 2.7 H), 6.43 (br s, 0.3 H), 4.13-4.81 (m, 1 H), 3.37-3.82 (m, 1 H), 2.78-3.18 (m, 2 H), 1.52-1.67 (m, 6 H) 445.3 [M+H] + 100%
758 (CD 3OD) δ 8.43 (s, 1 H), 8.34 (d, 1 H), 7.68 (s, 1 H), 6.91-7.31 (m, 2 H), 6.40-6.89 (m, 3 H), 4.28-4.83 (m, 1 H), 3.37-3.82 (m, 1 H), 2.74-3.16 (m, 2 H) 403.3 [M+H] 99.7%
759 (CD 3OD) δ 8.43 (s, 1 H), 8.34 (d, 1 H), 7.68 (s, 1 H), 6.92-7.31 (m, 2 H), 6.45-6.92 (m, 3 H), 4.27-4.83 (m, 1 H), 3.37-3.78 (m, 1 H), 2.77-3.13 (m, 2 H) 403.2 [M+H] 99.3%
760 (CD 3OD) δ 8.25-8.49 (m, 2 H), 7.58-8.13 (m, 2 H), 6.92-7.01 (m, 1 H), 6.53-6.91 (m, 3 H), 4.48 (br s, 1 H), 3.41-3.83 (m, 1 H), 2.74-3.15 (m, 2 H) 353.2 [M+H] + 100%
761 (CD 3OD) δ 8.26-8.50 (m, 2 H), 7.64-8.14 (m, 2 H), 6.92-7.01 (m, 1 H), 6.53-6.92 (m, 3 H), 4.39-4.79 (m, 1 H), 3.37-3.84 (m, 1 H), 2.73-3.17 (m, 2 H) 353.3 [M+H] + 99.3%
762 (CD 3OD) δ 8.35 (br d, 1 H), 7.70 (d, 1 H), 6.88-7.02 (m, 2 H), 6.50-6.88 (m, 2 H), 4.48 (dd, 1 H), 4.00-4.05 (m, 3 H), 3.62-3.71 (m, 0.6 H), 2.92-3.22 (m, 1.4 H), 2.71-2.87 (m, 1 H) 401.2 [M+H] + 100%
763 (CD 3OD) δ 8.35 (br d, 1 H), 7.70 (br d, 1 H), 6.88-7.01 (m, 2 H), 6.50-6.87 (m, 2 H), 4.48 (dd, 1 H), 3.98-4.07 (m, 3 H), 3.60-3.72 (m, 0.6 H), 2.92-3.24 (m, 1.4 H), 2.69-2.86 (m, 1 H) 401.2 [M+H] + 100%
764 (CD 3OD) δ 8.35 (t, 1 H), 7.70 (br d, 1 H), 6.68-7.03 (m, 4.6 H), 6.53 (s, 0.4 H), 4.47 (dd, 1 H), 4.06-4.16 (m, 3 H), 3.62-3.74 (m, 0.6 H), 2.93-3.24 (m, 1.4 H), 2.68-2.87 (m, 1 H) 417.2 [M+H] + 100%
765 (CD 3OD) δ 8.29-8.41 (m, 1 H), 7.70 (br s, 1 H), 6.70-7.02 (m, 4.7 H), 6.53 (s, 0.3 H), 4.47 (dd, 1 H), 4.06-4.15 (m, 3 H), 3.63-3.75 (m, 0.6 H), 2.93-3.23 (m, 1.4 H), 2.70-2.89 (m, 1 H) 417.2 [M+H] + 100%
766 (CD 3OD) δ 8.39 (s, 2 H), 7.59-8.16 (m, 2 H), 7.29 (d, 1 H), 6.53-6.91 (m, 3 H), 4.45-4.85 (m, 1 H), 3.74 (br s, 1 H), 2.71-3.17 (m, 2 H) 369.2 [M+H] + 100%
767 (CD 3OD) δ 8.40 (s, 2 H), 7.68-8.13 (m, 2 H), 7.30 (d, 1 H), 6.57-6.93 (m, 3 H), 4.42-4.84 (m, 1 H), 3.74 (br s, 1 H), 2.77-3.17 (m, 2 H) 369.2 [M+H] + 99.1%
768 (CD 3OD) δ 8.24-8.43 (m, 2 H), 8.08 (br s, 0.4 H), 7.77 (br s, 0.6 H), 7.68 (s, 1 H), 6.99 (br d, 1 H), 6.88 (br s, 1 H), 6.78 (br t, 1 H), 6.40-6.69 (m, 1 H), 4.47 (br s, 1 H), 3.76 (br s, 1 H), 2.91-3.17 (m, 1 H), 2.80 (br s, 1 H), 2.44 (s, 3 H) 348.9 [M+H] + 100%
769 (CD 3OD) δ 8.23-8.45 (m, 2 H), 8.08 (br s, 0.4 H), 7.61-7.86 (m, 1.6 H), 6.99 (br d, 1 H), 6.88 (br s, 1 H), 6.78 (br t, 1 H), 6.41-6.67 (m, 1 H), 4.78 (br s, 0.5 H), 4.47 (br s, 0.5 H), 3.76 (br s, 0.6 H), 3.35 (br s, 0.4 H), 2.91-3.16 (m, 1 H), 2.77 (br d, 1 H), 2.44 (s, 3 H) 349.0 [M+H] + 99.8%
770 (CD 3OD) δ 8.19-8.35 (m, 2 H), 7.67 (s, 1 H), 6.98 (d, 1 H), 6.71-6.90 (m, 2 H), 6.61 (br s, 1 H), 4.31 (br s, 1 H), 3.71 (br s, 1 H), 2.92-3.15 (m, 1 H), 2.78 (br d, 1 H), 2.33-2.51 (m, 6 H) 363.1 [M+H] + 100%
771 (CD 3OD) δ 8.17-8.38 (m, 2 H), 7.67 (s, 1 H), 6.98 (d, 1 H), 6.73-6.90 (m, 2 H), 6.60 (br s, 1 H), 4.29 (br s, 1 H), 3.72 (br s, 1 H), 2.90-3.18 (m, 1 H), 2.78 (br d, 1 H), 2.32-2.49 (m, 6 H) 363.0 [M+H] + 99.5%
772 (CD 3OD) δ 8.46-8.53 (m, 1 H), 8.31-8.39 (m, 1 H), 7.66-7.75 (m, 1 H), 6.81-7.03 (m, 3 H), 6.74 (s, 0.6 H), 6.54 (s, 0.2 H), 6.03 (s, 0.2 H), 3.41-3.88 (m, 2 H), 2.76-3.00 (m, 2 H) 421.0 [M+H] + 99.6%
773 (CD 3OD) δ 8.44-8.49 (m, 1 H), 8.29-8.36 (m, 1 H), 7.64-7.72 (m, 1 H), 6.79-7.01 (m, 3 H), 6.72 (s, 0.6 H), 6.52 (s, 0.2 H), 6.01 (br s, 0.2 H), 3.37-3.88 (m, 2 H), 2.89-2.99 (m, 1 H), 2.74-2.86 (m, 1 H) 421.0 [M+H] + 99.4%
774 (CD 3OD) δ 8.33 (d, 1 H), 8.25 (s, 1 H), 7.67 (s, 1 H), 6.95 (dd, 1 H), 6.49-6.88 (m, 3 H), 4.21-4.83 (m, 1 H), 3.38-3.85 (m, 1 H), 3.06 (br s, 1 H), 2.78 (br d, 1 H), 2.38 (s, 3 H) 367.1 [M+H] + 99.2%
775 (CD 3OD) δ 8.33 (d, 1 H), 8.25 (s, 1 H), 7.67 (s, 1 H), 6.96 (dd, 1 H), 6.49-6.88 (m, 3 H), 4.26-4.83 (m, 1 H), 3.35-3.82 (m, 1 H), 2.96-3.14 (m, 1 H), 2.78 (br d, 1 H), 2.38 (s, 3 H) 367.0 [M+H] + 99.7%
776 (CD 3OD) δ 8.28-8.48 (m, 1 H), 7.50-7.84 (m, 3 H), 6.74-7.08 (m, 4 H), 6.15-6.56 (m, 1 H), 4.82 (br s, 0.5 H), 4.05-4.14 (m, 0.5 H), 3.64-3.78 (m, 0.5 H), 3.12-3.29 (m, 0.5 H), 2.70-3.06 (m, 2 H) 402.0 [M+H] + 99.5%
777 (CD 3OD) δ 8.29-8.47 (m, 1 H), 7.50-7.84 (m, 3 H), 6.25-7.11 (m, 5 H), 4.84 (br d, 0.5 H), 4.04-4.12 (m, 0.5 H), 3.61-3.78 (m, 0.5 H), 3.19-3.28 (m, 0.5 H), 2.92-3.06 (m, 1 H), 2.75 (br d, 1 H) 402.0 [M+H] + 99.3%
778 (CD 3OD) δ 8.78 (br d, 1 H), 8.26-8.36 (m, 1 H), 7.99-8.14 (m, 2 H), 7.59-7.74 (m, 2 H), 7.50 (s, 0.3 H), 6.97 (s, 0.7 H), 6.72-6.84 (m, 1 H), 6.63-6.71 (m, 1 H), 6.54-6.62 (m, 1 H), 5.00 (dd, 1 H), 3.86-4.06 (m, 3 H), 3.72-3.85 (m, 0.7 H), 3.43 (td, 0.3 H), 2.93-3.29 (m, 1 H), 2.86 (br dd, 1 H) 443.0 [M+H] + 100%
779 (CD 3OD) δ 8.78 (br d, 1 H), 8.28-8.34 (m, 1 H), 7.99-8.16 (m, 2 H), 7.61-7.78 (m, 2 H), 7.50 (s, 0.3 H), 6.97 (s, 0.7 H), 6.74-6.83 (m, 1 H), 6.63-6.72 (m, 1 H), 6.52-6.62 (m, 1 H), 5.00 (br dd, 1 H), 3.92-4.00 (m, 3 H), 3.72-3.84 (m, 0.7 H), 3.43 (td, 0.3 H), 2.96-3.27 (m, 1 H), 2.86 (br dd, 1 H) 443.0 [M+H] + 100%
780 (CD 3OD) δ 8.40-8.53 (m, 1 H), 7.70 (d, 1 H), 7.24-7.33 (m, 1 H), 6.67-7.00 (m, 3.7 H), 6.51 (s, 0.3 H), 4.92 (br d, 0.3 H), 4.47 (dd, 0.7 H), 4.05-4.15 (m, 3 H), 3.68 (ddd, 0.5 H), 2.93-3.27 (m, 1.5 H), 2.72-2.88 (m, 1 H) 433.0 [M+H] + 100%
781 (CD 3OD) δ 8.36-8.52 (m, 1 H), 7.70 (d, 1 H), 7.24-7.36 (m, 1 H), 6.65-7.01 (m, 3.7 H), 6.51 (s, 0.3 H), 4.92 (br d, 0.4 H), 4.47 (dd, 0.6 H), 4.05-4.17 (m, 3 H), 3.68 (ddd, 0.6 H), 2.92-3.27 (m, 1.4 H), 2.71-2.89 (m, 1 H) 432.9 [M+H] + 99.5%
782 (CD 3OD) δ 8.40-8.58 (m, 1 H), 7.49-7.85 (m, 3 H), 7.30 (d, 1 H), 6.71-7.11 (m, 3.2 H), 6.25-6.54 (m, 0.8 H), 4.83 (br s, 0.5 H), 4.02-4.14 (m, 0.5 H), 3.71 (br t, 0.5 H), 3.17-3.29 (m, 0.5 H), 2.93-3.06 (m, 1 H), 2.75 (br d, 1 H) 417.9 [M+H] + 99.6%
783 (CD 3OD) δ 8.36-8.59 (m, 1 H), 7.47-7.88 (m, 3 H), 7.30 (d, 1 H), 6.67-7.13 (m, 3.2 H), 6.18-6.57 (m, 0.8 H), 4.82 (br s, 0.5 H), 4.09 (br dd, 0.5 H), 3.62-3.79 (m, 0.5 H), 3.15-3.28 (m, 0.5 H), 2.90-3.07 (m, 1 H), 2.76 (br d, 1 H) 418.0 [M+H] + 99.6%
784 (CD 3OD) δ 8.27-8.50 (m, 2 H), 7.51-7.76 (m, 2 H), 7.03-7.25 (m, 2 H), 6.89-7.02 (m, 1 H), 6.81 (br t, 1 H), 4.26 (br s, 1 H), 4.06 (br s, 1 H), 3.05 (br d, 1 H), 2.86 (br d, 1 H), 2.34-2.63 (m, 3 H) 399.0 [M+H] + 100%
785 (CD 3OD) δ 8.42 (br s, 1 H), 8.31-8.38 (m, 1 H), 7.65 (s, 1 H), 7.53-7.62 (m, 1 H), 7.03-7.22 (m, 2 H), 6.95 (br d, 1 H), 6.82 (br s, 1 H), 4.26 (br s, 1 H), 4.06 (br s, 1 H), 2.99-3.12 (m, 1 H), 2.86 (dd, 1 H), 2.47 (br s, 3 H) 399.0 [M+H] + 99.8%
786 (CD 3OD) δ 8.35 (d, 1 H), 7.74 (s, 1 H), 7.59 (br d, 1 H), 7.15-7.20 (m, 1 H), 6.88-7.14 (m, 2 H), 6.82 (td, 1 H), 4.29 (br s, 1 H), 4.07 (br s, 1 H), 3.13 (br d, 1 H), 2.89 (dd, 1 H), 2.47 (br s, 3 H), 1.67 (s, 6 H) 457.0 [M+H] + 97.5%
787 (CD 3OD) δ 8.35 (d, 1 H), 7.93 (br s, 1 H), 7.60 (br d, 1 H), 7.18 (t, 1 H), 6.89-7.10 (m, 2 H), 6.84 (td, 1 H), 4.32 (br s, 1 H), 4.05 (br s, 1 H), 3.15 (br s, 1 H), 2.80-2.97 (m, 1 H), 2.48 (br s, 3 H), 1.67 (s, 6 H) 457.0 [M+H] + 99.0%
788 (CD 3OD) δ 8.44 (d, 1 H), 8.22-8.38 (m, 2 H), 7.70 (s, 1 H), 7.51-7.63 (m, 1.3 H), 6.91-7.01 (m, 1.7 H), 6.74-6.88 (m, 2 H), 4.94-5.08 (m, 1 H), 3.99 (s, 3 H), 3.72-3.85 (m, 0.7 H), 3.42 (td, 0.3 H), 2.96-3.25 (m, 1 H), 2.78-2.91 (m, 1 H) 461.1 [M+H] + 96.7%
789 (CD 3OD) δ 8.44 (d, 1 H), 8.21-8.39 (m, 2 H), 7.70 (s, 1 H), 7.51-7.63 (m, 1.3 H), 6.92-7.01 (m, 1.7 H), 6.72-6.88 (m, 2 H), 4.93-5.08 (m, 1 H), 3.99 (s, 3 H), 3.73-3.85 (m, 0.7 H), 3.42 (td, 0.3 H), 2.97-3.24 (m, 1 H), 2.85 (br d, 1 H) 461.2 [M+H] + 90.1%
790 (CD 3OD) δ 8.64 (d, 1 H), 8.27-8.39 (m, 1 H), 7.94 (t, 1 H), 7.67-7.80 (m, 2 H), 7.46 (s, 0.4 H), 6.94-7.00 (m, 1.6 H), 6.71-6.89 (m, 2 H), 4.98 (br dd, 1 H), 3.74-3.85 (m, 0.7 H), 3.38-3.50 (m, 0.3 H), 2.97-3.26 (m, 1 H), 2.85 (br d, 1 H) 449.1 [M+H] + 98.8%
791 (CD 3OD) δ 8.64 (d, 1 H), 8.26-8.38 (m, 1 H), 7.93 (td, 1 H), 7.68-7.79 (m, 2 H), 7.46 (s, 0.4 H), 6.93-6.99 (m, 1.6 H), 6.76-6.89 (m, 2 H), 4.98 (dd, 1 H), 3.76-3.85 (m, 0.7 H), 3.43 (td, 0.3 H), 2.98-3.26 (m, 1 H), 2.81-2.91 (m, 1 H) 449.1 [M+H] + 98.4%
792 (CD 3OD) δ 8.43 (s, 1 H), 7.66 (s, 1 H), 7.45 (br s, 1 H), 6.96-7.30 (m, 2 H), 6.34-6.96 (m, 3 H), 4.18-4.43 (m, 1 H), 3.36-3.98 (m, 1 H), 2.89-3.16 (m, 1 H), 2.80 (dd, 1 H), 2.65 (br s, 3 H) 399.2 [M+H] + 100%
793 (CD 3OD) δ 8.43 (s, 1 H), 7.67 (s, 1 H), 7.46 (br d, 1 H), 6.97-7.29 (m, 2 H), 6.38-6.94 (m, 3 H), 4.29 (br s, 1 H), 3.35-3.97 (m, 1 H), 3.01 (br s, 1 H), 2.80 (dd, 1 H), 2.65 (br s, 3 H) 399.1 [M+H] + 100%
794 (CD 3OD) δ 7.66 (s, 1 H), 7.46 (br s, 1 H), 6.93-7.28 (m, 2 H), 6.41-6.90 (m, 3 H), 4.74-4.87 (m, 0.7 H), 4.33 (br s, 0.3 H), 3.36-3.93 (m, 1 H), 2.76-3.18 (m, 2 H), 2.55-2.72 (m, 3 H), 1.36-1.81 (m, 6 H) 457.2 [M+H] + 100%
795 (CD 3OD) δ 7.67 (s, 1 H), 7.45 (br s, 1 H), 6.94-7.27 (m, 2 H), 6.44-6.90 (m, 3 H), 4.75-4.86 (m, 0.5 H), 4.34 (br d, 0.5 H), 3.35-3.93 (m, 1 H), 2.74-3.17 (m, 2 H), 2.55-2.72 (m, 3 H), 1.54-1.72 (m, 6 H) 457.2 [M+H] + 99.2%
796 (CD 3OD) δ 8.92 (s, 1 H), 8.27-8.39 (m, 2 H), 7.46-7.85 (m, 2.3 H), 6.91-7.05 (m, 1.7 H), 6.71-6.88 (m, 2 H), 4.92-5.13 (m, 1 H), 3.37-3.84 (m, 1 H), 2.90-3.22 (m, 1 H), 2.84 (br d, 1 H) 470.1 [M+H] + 100%
797 (CD 3OD) δ 8.92 (s, 1 H), 8.25-8.40 (m, 2 H), 7.48-7.83 (m, 2.4 H), 6.92-7.01 (m, 1.6 H), 6.72-6.88 (m, 2 H), 4.92-5.14 (m, 1 H), 3.37-3.84 (m, 1 H), 2.95-3.24 (m, 1 H), 2.86 (br d, 1 H) 470.1 [M+H] + 99.4%
798 (CD 3OD) δ 8.74-8.82 (m, 1 H), 8.26-8.37 (m, 1 H), 8.09 (tt, 1 H), 7.60-7.75 (m, 2 H), 7.38-7.54 (m, 1.5 H), 7.04-7.18 (m, 1 H), 7.00 (s, 0.5 H), 6.60-6.77 (m, 1.6 H), 6.45 (s, 0.4 H), 4.92-5.04 (m, 1 H), 3.89-4.00 (m, 0.5 H), 3.35-3.43 (m, 0.5 H), 2.96-3.25 (m, 1 H), 2.82-2.92 (m, 1 H), 2.44-2.71 (m, 3 H) 427.1 [M+H] + 100%
799 (CD 3OD) δ 8.73-8.81 (m, 1 H), 8.27-8.35 (m, 1 H), 8.08 (tt, 1 H), 7.62-7.74 (m, 2 H), 7.37-7.52 (m, 1.5 H), 7.05-7.15 (m, 1 H), 7.00 (s, 0.5 H), 6.59-6.76 (m, 1.6 H), 6.44 (s, 0.4 H), 4.93-5.03 (m, 1 H), 3.93 (br t, 0.5 H), 3.35-3.43 (m, 0.5 H), 2.94-3.25 (m, 1 H), 2.82-2.91 (m, 1 H), 2.44-2.70 (m, 3 H) 427.2 [M+H] + 100%
800 (CD 3OD) δ 8.39 (d, 1 H), 8.09 (s, 1 H), 7.68 (d, 1 H), 7.38-7.52 (m, 1.5 H), 7.10 (ddd, 1 H), 6.97 (s, 0.5 H), 6.41-6.76 (m, 2 H), 4.91-5.11 (m, 1 H), 4.00 (d, 3 H), 3.85-3.95 (m, 0.6 H), 3.34-3.40 (m, 0.4 H), 2.93-3.22 (m, 1 H), 2.84 (dt, 1 H), 2.48-2.69 (m, 3 H) 430.2 [M+H] + 100%
801 (CD 3OD) δ 8.39 (s, 1 H), 8.10 (s, 1 H), 7.69 (d, 1 H), 7.39-7.52 (m, 1.5 H), 7.10 (ddd, 1 H), 6.98 (s, 0.5 H), 6.42-6.75 (m, 2 H), 4.92-5.11 (m, 1 H), 4.00 (d, 3 H), 3.86-3.95 (m, 0.5 H), 3.33-3.41 (m, 0.5 H), 2.94-3.21 (m, 1 H), 2.84 (dt, 1 H), 2.48-2.69 (m, 3 H) 430.2 [M+H] + 99.4%
802 (CD 3OD) δ 7.81 (dd, 1 H), 7.70 (d, 1 H), 7.36-7.52 (m, 1.5 H), 7.05-7.16 (m, 1 H), 6.98 (s, 1.5 H), 6.64-6.77 (m, 1 H), 6.35-6.63 (m, 1 H), 5.01 (br dd, 1 H), 4.03 (d, 3 H), 3.84-3.95 (m, 0.6 H), 3.33-3.39 (m, 0.4 H), 2.93-3.22 (m, 1 H), 2.78-2.90 (m, 1 H), 2.47-2.68 (m, 3 H) 430.2 [M+H] + 100%
803 (CD 3OD) δ 7.82 (dd, 1 H), 7.69 (d, 1 H), 7.38-7.53 (m, 1.5 H), 7.04-7.18 (m, 1 H), 6.99 (d, 1.5 H), 6.64-6.76 (m, 1 H), 6.41-6.64 (m, 1 H), 5.01 (br dd, 1 H), 4.03 (d, 3 H), 3.84-3.96 (m, 0.6 H), 3.34-3.39 (m, 0.4 H), 2.93-3.24 (m, 1 H), 2.80-2.91 (m, 1 H), 2.45-2.72 (m, 3 H) 430.2 [M+H] + 100%
804 (CD 3OD) δ 8.24 (s, 1 H), 7.67 (br s, 1 H), 7.49 (br d, 1 H), 7.11-7.28 (m, 0.7 H), 7.08 (d, 1 H), 6.99 (s, 0.3 H), 6.47-6.88 (m, 2 H), 4.31 (br d, 1 H), 3.73 (br s, 1 H), 2.91-3.20 (m, 1 H), 2.81 (br d, 1 H), 2.32 (s, 3 H), 1.51-1.72 (m, 6 H) 457.1 [M+H] + 100%
805 (CD 3OD) δ 8.24 (s, 1 H), 7.66 (br s, 1 H), 7.49 (br d, 1 H), 7.11-7.29 (m, 0.8 H), 7.08 (d, 1 H), 6.99 (s, 0.2 H), 6.46-6.89 (m, 2 H), 4.31 (br d, 1 H), 3.73 (br s, 1 H), 2.90-3.20 (m, 1 H), 2.81 (br d, 1 H), 2.25-2.35 (m, 3 H), 1.52-1.76 (m, 6 H) 457.2 [M+H] + 99.2%
806 (CD 3OD) δ 8.24-8.37 (m, 1 H), 8.00 (s, 1 H), 7.81-7.89 (m, 1 H), 7.46-7.75 (m, 1.4 H), 6.93-7.09 (m, 1.6 H), 6.73-6.86 (m, 1 H), 6.53-6.70 (m, 1 H), 5.07 (dd, 1 H), 4.05-4.15 (m, 3 H), 3.37-3.85 (m, 1 H), 2.96-3.27 (m, 1 H), 2.79-2.93 (m, 1 H), 2.36-2.52 (m, 3 H) 430.2 [M+H] + 100%
807 (CD 3OD) δ 8.25-8.37 (m, 1 H), 8.00 (s, 1 H), 7.83-7.94 (m, 1 H), 7.54-7.80 (m, 1.3 H), 6.96-7.09 (m, 1.7 H), 6.73-6.87 (m, 1 H), 6.51-6.69 (m, 1 H), 5.07 (dd, 1 H), 4.09-4.19 (m, 3 H), 3.38-3.89 (m, 1 H), 2.95-3.26 (m, 1 H), 2.78-2.91 (m, 1 H), 2.40-2.52 (m, 3 H) 430.2 [M+H] + 93.0%
808 (CD 3OD) δ 8.31-8.45 (m, 1 H), 8.00 (s, 1 H), 7.83-7.91 (m, 1 H), 7.50-7.80 (m, 1.4 H), 6.94-7.06 (m, 1.6 H), 6.72-6.91 (m, 2 H), 5.10 (dd, 1 H), 4.10-4.20 (m, 3 H), 3.38-3.88 (m, 1 H), 2.96-3.29 (m, 1 H), 2.80-2.93 (m, 1 H) 434.2 [M+H] + 92.5%
809 (CD 3OD) δ 8.29-8.40 (m, 1 H), 7.99 (s, 1 H), 7.84-7.89 (m, 1 H), 7.50-7.76 (m, 1.4 H), 6.94-7.04 (m, 1.6 H), 6.74-6.90 (m, 2 H), 4.94-5.13 (m, 1 H), 4.10-4.14 (m, 3 H), 3.38-3.87 (m, 1 H), 2.97-3.28 (m, 1 H), 2.80-2.91 (m, 1 H) 434.2 [M+H] + 100%
810 (CD 3OD) δ 8.69 (d, 1 H), 7.69 (s, 1 H), 7.63 (br d, 1 H), 7.10-7.29 (m, 1 H), 6.96-7.01 (m, 1 H), 6.54-6.90 (m, 2 H), 4.37 (br d, 1 H), 3.74 (br s, 1 H), 2.71-3.21 (m, 2 H), 1.55-1.70 (m, 6 H) 511.2 [M+H] + 98.3%
811 (CD 3OD) δ 8.69 (d, 1 H), 7.61-7.71 (m, 2 H), 7.11-7.27 (m, 1 H), 6.99 (t, 1 H), 6.57-6.91 (m, 2 H), 4.37 (br d, 1 H), 3.64-3.84 (m, 1 H), 2.75-3.21 (m, 2 H), 1.53-1.69 (m, 6 H) 511.2 [M+H] + 99.6%
812 (CD 3OD) δ 8.77 (br d, 1 H), 8.15-8.39 (m, 2 H), 8.09 (br t, 1 H), 7.61-7.73 (m, 2 H), 7.40-7.57 (m, 1 H), 7.02-7.14 (m, 1 H), 6.96 (s, 1 H), 6.46-6.64 (m, 1 H), 4.98 (br dd, 1 H), 3.74-3.85 (m, 0.9 H), 3.40 (br d, 0.1 H), 2.93-3.26 (m, 1 H), 2.84 (br d, 1 H), 2.23-2.37 (m, 3 H) 427.2 [M+H] + 100%
813 (CD 3OD) δ 8.77 (dd, 1 H), 8.15-8.34 (m, 2 H), 8.03-8.12 (m, 1 H), 7.62-7.72 (m, 2 H), 7.41-7.53 (m, 1 H), 7.01-7.12 (m, 1 H), 6.95 (s, 1 H), 6.49-6.60 (m, 1 H), 4.98 (br dd, 1 H), 3.74-3.88 (m, 0.8 H), 3.38-3.49 (m, 0.2 H), 3.13-3.26 (m, 0.7 H), 2.93-3.06 (m, 0.3 H), 2.78-2.89 (m, 1 H), 2.23-2.36 (m, 3 H) 427.2 [M+H] + 99.9%
814 (CD 3OD) δ 8.15-8.29 (m, 1 H), 7.81 (d, 1 H), 7.68 (s, 1 H), 7.41-7.54 (m, 1 H), 7.03-7.12 (m, 1 H), 6.98-7.01 (m, 1 H), 6.94 (s, 1 H), 6.45-6.60 (m, 1 H), 5.00 (br dd, 1 H), 3.99-4.07 (m, 3 H), 3.71-3.82 (m, 0.7 H), 3.36-3.45 (m, 0.3 H), 2.93-3.23 (m, 1 H), 2.83 (br d, 1 H), 2.25-2.35 (m, 3 H) 430.2 [M+H] + 100%
815 (CD 3OD) δ 8.17-8.29 (m, 1 H), 7.78-7.84 (m, 1 H), 7.69 (s, 1 H), 7.41-7.56 (m, 1 H), 7.03-7.13 (m, 1 H), 6.97-7.02 (m, 1 H), 6.94 (s, 1 H), 6.42-6.61 (m, 1 H), 5.00 (br dd, 1 H), 4.00-4.06 (m, 3 H), 3.70-3.83 (m, 0.6 H), 3.34-3.45 (m, 0.4 H), 2.92-3.24 (m, 1 H), 2.74-2.89 (m, 1 H), 2.26-2.35 (m, 3 H) 430.2 [M+H] + 99.9%
816 (CD 3OD) δ 8.42 (d, 1 H), 8.18-8.32 (m, 2 H), 7.70 (s, 1 H), 7.49-7.62 (m, 1 H), 6.92-7.01 (m, 2 H), 6.69-6.80 (m, 1 H), 6.55-6.66 (m, 1 H), 5.01 (br dd, 1 H), 3.97 (s, 3 H), 3.68-3.87 (m, 0.7 H), 3.37-3.49 (m, 0.3 H), 2.93-3.25 (m, 1 H), 2.77-2.89 (m, 1 H), 2.35-2.48 (m, 3 H) 457.2 [M+H] + 100%
817 (CD 3OD) δ 8.43 (d, 1 H), 8.14-8.34 (m, 2 H), 7.69-7.78 (m, 1 H), 7.51-7.63 (m, 1 H), 6.92-7.03 (m, 2 H), 6.70-6.83 (m, 1 H), 6.53-6.68 (m, 1 H), 5.02 (br dd, 1 H), 3.98 (s, 3 H), 3.71-3.85 (m, 0.7 H), 3.42 (td, 0.3 H), 3.12-3.26 (m, 0.7 H), 2.95-3.07 (m, 0.3 H), 2.76-2.91 (m, 1 H), 2.39-2.49 (m, 3 H) 457.2 [M+H] + 100%
818 (CD 3OD) δ 8.58-8.66 (m, 1 H), 8.19-8.34 (m, 1 H), 7.83-7.98 (m, 1 H), 7.64-7.77 (m, 2 H), 7.46 (s, 0.3 H), 6.90-7.03 (m, 1.7 H), 6.70-6.82 (m, 1 H), 6.55-6.67 (m, 1 H), 4.92-5.01 (m, 1 H), 3.70-3.86 (m, 0.7 H), 3.44 (td, 0.3 H), 2.95-3.27 (m, 1 H), 2.76-2.91 (m, 1 H), 2.35-2.50 (m, 3 H) 445.2 [M+H] + 99.4%
819 (CD 3OD) δ 8.58-8.68 (m, 1 H), 8.20-8.34 (m, 1 H), 7.92 (t, 1 H), 7.65-7.80 (m, 2 H), 7.46 (s, 0.3 H), 6.90-7.02 (m, 1.7 H), 6.70-6.84 (m, 1 H), 6.56-6.69 (m, 1 H), 4.92-5.01 (m, 1 H), 3.72-3.86 (m, 0.7 H), 3.44 (td, 0.3 H), 3.15-3.27 (m, 0.7 H), 2.95-3.07 (m, 0.3 H), 2.85 (br dd, 1 H), 2.34-2.49 (m, 3 H) 445.2 [M+H] + 99.6%
820 (CD 3OD) δ 8.92 (s, 1 H), 8.21-8.40 (m, 2 H), 7.49-7.81 (m, 2 H), 6.92-7.03 (m, 2 H), 6.71-6.83 (m, 1 H), 6.51-6.67 (m, 1 H), 4.98-5.12 (m, 1 H), 3.70-3.87 (m, 0.7 H), 3.38-3.47 (m, 0.3 H), 2.94-3.23 (m, 1 H), 2.77-2.91 (m, 1 H), 2.37-2.48 (m, 3 H) 466.2 [M+H] + 98.8%
821 (CD 3OD) δ 8.77-9.00 (m, 1 H), 8.20-8.40 (m, 2 H), 7.48-7.82 (m, 2 H), 6.98 (br t, 2 H), 6.70-6.82 (m, 1 H), 6.54-6.68 (m, 1 H), 5.06 (br dd, 1 H), 3.67-3.86 (m, 0.7 H), 3.41 (td, 0.3 H), 2.93-3.26 (m, 1 H), 2.85 (br d, 1 H), 2.35-2.51 (m, 3 H) 466.2 [M+H] + 99.5%
822 (CD 3OD) δ 8.20-8.37 (m, 2 H), 7.48-7.85 (m, 2 H), 7.17-7.25 (m, 1 H), 6.92-7.03 (m, 2 H), 6.70-6.82 (m, 1 H), 6.53-6.66 (m, 1 H), 5.02 (dd, 1 H), 3.73-3.86 (m, 0.7 H), 3.42 (td, 0.3 H), 2.94-3.25 (m, 1 H), 2.77-2.89 (m, 1 H), 2.38-2.48 (m, 3 H) 466.2 [M+H] + 100%
823 (CD 3OD) δ 8.21-8.35 (m, 2 H), 7.82 (s, 0.3 H), 7.69 (d, 1 H), 7.53 (s, 0.6 H), 7.18-7.23 (m, 1 H), 6.93-7.02 (m, 2 H), 6.71-6.81 (m, 1 H), 6.53-6.66 (m, 1 H), 5.02 (dd, 1 H), 3.72-3.85 (m, 0.7 H), 3.42 (td, 0.3 H), 2.95-3.25 (m, 1 H), 2.76-2.89 (m, 1 H), 2.39-2.48 (m, 3 H) 466.2 [M+H] + 100%
824 (CD 3OD) δ 8.26-8.39 (m, 2 H), 7.50-7.84 (m, 2.4 H), 7.21 (d, 1 H), 6.93-7.01 (m, 1.6 H), 6.70-6.88 (m, 2 H), 4.92-5.08 (m, 1 H), 3.74-3.86 (m, 0.7 H), 3.42 (br dd, 0.3 H), 3.15-3.24 (m, 0.7 H), 2.96-3.04 (m, 0.3 H), 2.80-2.91 (m, 1 H) 470.2 [M+H] + 99.5%
825 (CD 3OD) δ 8.23-8.43 (m, 2 H), 7.47-7.88 (m, 2.4 H), 7.21 (d, 1 H), 6.91-7.04 (m, 1.6 H), 6.72-6.89 (m, 2 H), 5.04 (br dd, 1 H), 3.73-3.85 (m, 0.5 H), 3.38-3.45 (m, 0.5 H), 3.12-3.24 (m, 0.8 H), 2.97-3.05 (m, 0.2 H), 2.78-2.91 (m, 1 H) 470.2 [M+H] + 100%
826 (CD 3OD) δ 8.63-8.80 (m, 2 H), 8.31 (d, 1 H), 8.09 (td, 1 H), 7.59-7.72 (m, 3 H), 6.72-7.10 (m, 3 H), 4.92-5.07 (m, 1 H), 3.38-3.85 (m, 1 H), 2.83-3.25 (m, 2 H) 481.2 [M+H] + 100%
827 (CD 3OD) δ 8.63-8.80 (m, 2 H), 8.31 (d, 1 H), 8.08 (td, 1 H), 7.58-7.72 (m, 3 H), 6.75-7.07 (m, 3 H), 4.93-5.07 (m, 1 H), 3.39-3.83 (m, 1 H), 2.84-3.26 (m, 2 H) 481.2 [M+H]+ 98.1%
828 (CD 3OD) δ 8.66-8.73 (m, 1 H), 8.39-8.43 (m, 1 H), 8.08-8.17 (m, 1 H), 7.72 (s, 1 H), 7.59-7.66 (m, 1 H), 6.93-7.05 (m, 2 H), 6.76-6.84 (m, 1 H), 4.94-5.16 (m, 1 H), 4.02 (s, 3 H), 3.41-3.81 (m, 1 H), 2.84-3.22 (m, 2 H) 484.2 [M+H] + 100%
829 (CD 3OD) δ 8.66-8.73 (m, 1 H), 8.39-8.43 (m, 1 H), 8.09-8.15 (m, 1 H), 7.62-7.73 (m, 2 H), 6.94-7.05 (m, 2 H), 6.77-6.83 (m, 1 H), 4.95-5.17 (m, 1 H), 4.02 (s, 3 H), 3.41-3.82 (m, 1 H), 2.84-3.22 (m, 2 H) 484.2 [M+H] + 98.2%
830 (CD 3OD) δ 8.83 (d, 2 H), 8.23-8.43 (m, 1 H), 8.03-8.19 (m, 2 H), 7.46-7.80 (m, 1.3 H), 6.90-7.06 (m, 1.7 H), 6.71-6.89 (m, 2 H), 5.07 (br dd, 0.7 H), 4.92-4.97 (m, 0.3 H), 3.80 (br t, 0.7 H), 3.43 (br t, 0.3 H), 2.96-3.25 (m, 1 H), 2.89 (br s, 1 H) 431.2 [M+H] + 100%
831 (CD 3OD) δ 8.83 (d, 2 H), 8.26-8.42 (m, 1 H), 8.12 (d, 2 H), 7.46-7.83 (m, 1.3 H), 6.91-7.08 (m, 1.7 H), 6.64-6.89 (m, 2 H), 5.07 (br dd, 0.7 H), 4.92-4.97 (m, 0.3 H), 3.80 (br t, 0.7 H), 3.38-3.50 (m, 0.3 H), 2.96-3.26 (m, 1 H), 2.87 (br s, 1 H) 431.2 [M+H] + 99.7%
832 (CD 3OD) δ 8.48 (s, 1 H), 8.25-8.39 (m, 1 H), 8.14 (s, 1 H), 7.52-7.76 (m, 1.4 H), 6.90-7.04 (m, 1.6 H), 6.78-6.89 (m, 1 H), 6.69-6.78 (m, 1 H), 5.10 (br dd, 0.5 H), 4.95 (br s, 0.5 H), 3.71-3.84 (m, 0.8 H), 3.38-3.43 (m, 0.2 H), 2.94-3.23 (m, 2 H), 2.84 (br d, 1 H), 2.48-2.65 (m, 4 H), 1.88-1.98 (m, 2 H) 474.2 [M+H] + 100%
833 (CD 3OD) δ 8.48 (s, 1 H), 8.24-8.39 (m, 1 H), 8.14 (s, 1 H), 7.55-7.75 (m, 1.4 H), 6.90-7.02 (m, 1.6 H), 6.80-6.88 (m, 1 H), 6.68-6.78 (m, 1 H), 4.98-5.15 (m, 1 H), 3.72-3.83 (m, 0.8 H), 3.42 (br d, 0.2 H), 2.93-3.26 (m, 2 H), 2.84 (br d, 1 H), 2.48-2.64 (m, 4 H), 1.88-1.97 (m, 2 H) 474.2 [M+H] + 99.4%
834 (CD 3OD) δ 8.98 (s, 1 H), 8.46 (s, 1 H), 8.26-8.39 (m, 1 H), 7.49-7.77 (m, 1 H), 6.90-7.03 (m, 2 H), 6.79-6.89 (m, 1 H), 6.72-6.78 (m, 1 H), 5.08 (dd, 1 H), 3.71-3.85 (m, 1 H), 3.36-3.52 (m, 1 H), 2.92-3.26 (m, 2 H), 2.85 (br d, 1 H), 1.41-1.55 (m, 2 H), 1.25-1.32 (m, 2 H) 524.2 [M+H]+ 100%
835 (CD 3OD) δ 8.98 (s, 1 H), 8.46 (s, 1 H), 8.24-8.38 (m, 1 H), 7.51-7.78 (m, 1 H), 6.90-7.02 (m, 2 H), 6.80-6.89 (m, 1 H), 6.71-6.78 (m, 1 H), 5.08 (br dd, 1 H), 3.65-3.92 (m, 1 H), 3.36-3.51 (m, 1 H), 2.94-3.24 (m, 2 H), 2.77-2.91 (m, 1 H), 1.42-1.53 (m, 2 H), 1.23-1.32 (m, 2 H) 524.2 [M+H] + 99.5%
836 以上所提供之數據
837 以上所提供之數據
838 (CD 3OD) δ 8.22-8.41 (m, 1 H), 7.94-8.07 (m, 1 H), 7.70 (s, 1 H), 6.74-7.07 (m, 3 H), 6.64 (s, 0.6 H), 6.34 (s, 0.4 H), 4.94 (br d, 0.4 H), 4.40 (dd, 0.6 H), 3.98-4.12 (m, 3 H), 3.65-3.75 (m, 0.5 H), 2.71-3.29 (m, 2.5 H), 2.37-2.51 (m, 3 H) 363.2 [M+H] + 100%
839 (CD 3OD) δ 8.14-8.27 (m, 1 H), 7.84-7.94 (m, 1 H), 7.59 (d, 1 H), 6.62-6.94 (m, 3 H), 6.52 (s, 0.6 H), 6.22 (s, 0.4 H), 4.82 (br s, 0.4 H), 4.28 (dd, 0.6 H), 3.84-4.01 (m, 3 H), 3.53-3.63 (m, 0.5 H), 2.59-3.17 (m, 2.5 H), 2.22-2.42 (m, 3 H) 363.2 [M+H] + 98.9%
840 (CD 3OD) δ 8.31-8.39 (m, 1 H), 8.00 (s, 1 H), 7.69 (d, 1 H), 6.73-7.02 (m, 3.5 H), 6.49 (s, 0.5 H), 4.90-4.94 (m, 0.5 H), 4.40 (dd, 0.5 H), 4.00-4.09 (m, 3 H), 3.61-3.72 (m, 0.5 H), 2.70-3.27 (m, 2.5 H) 367.2 [M+H] + 98.5%
841 (CD 3OD) δ 8.33-8.41 (m, 1 H), 8.02 (s, 1 H), 7.71 (d, 1 H), 6.74-7.02 (m, 3.5 H), 6.51 (s, 0.5 H), 4.92-4.96 (m, 0.5 H), 4.42 (dd, 0.5 H), 4.04-4.09 (m, 3 H), 3.64-3.73 (m, 0.5 H), 2.71-3.30 (m, 2.5 H) 367.2 [M+H] + 98.3%
842 (CD 3OD) δ 8.33-8.45 (m, 1 H), 7.86-7.92 (m, 1 H), 7.70 (br d, 1 H), 6.94-7.03 (m, 2 H), 6.69-6.93 (m, 2.3 H), 6.48 (s, 0.3 H), 6.03 (s, 0.4 H), 4.86 (br d, 0.6 H), 3.69-3.88 (m, 1 H), 3.35-3.42 (m, 0.4 H), 2.69-3.05 (m, 2 H) 420.1 [M+H] + 96.9%
843 (CD 3OD) δ 8.31-8.47 (m, 1 H), 7.83-7.96 (m, 1 H), 7.70 (br d, 1 H), 6.94-7.04 (m, 2 H), 6.83-6.92 (m, 1 H), 6.71-6.81 (m, 1.3 H), 6.48 (s, 0.3 H), 6.03 (s, 0.4 H), 4.86 (br d, 0.6 H), 3.69-3.86 (m, 1 H), 3.34-3.43 (m, 0.4 H), 2.68-3.05 (m, 2 H) 420.2 [M+H] + 92.8%
844 (CD 3OD) δ 8.23-8.34 (m, 2 H), 7.52-7.72 (m, 1 H), 6.93-7.04 (m, 2 H), 6.52-6.85 (m, 2 H), 5.06 (br dd, 1 H), 3.92 (s, 3 H), 3.72-3.81 (m, 1 H), 2.79-3.22 (m, 2 H), 2.51-2.56 (m, 3 H), 2.40-2.47 (m, 3 H)) 444.2 [M+H] + 98.0%
845 (CD 3OD) δ 8.20-8.34 (m, 2 H), 7.53-7.71 (m, 1 H), 6.90-7.05 (m, 2 H), 6.48-6.83 (m, 2 H), 5.06 (br dd, 1 H), 3.92 (s, 3 H), 3.71-3.83 (m, 1 H), 2.77-3.22 (m, 2 H), 2.51-2.57 (m, 3 H), 2.38-2.49 (m, 3 H) 444.2 [M+H] + 98.3%
846 (CD 3OD) δ 8.24-8.38 (m, 2 H), 7.53-7.72 (m, 1 H), 6.68-7.02 (m, 4 H), 5.09 (dd, 1 H), 3.92 (s, 3 H), 3.70-3.80 (m, 1 H), 2.73-3.24 (m, 2 H), 2.45-2.59 (m, 3 H) 448.2 [M+H] + 98.2%
847 (CD 3OD) δ 8.27-8.37 (m, 2 H), 7.47-7.71 (m, 1 H), 6.65-7.04 (m, 4 H), 5.09 (br dd, 1 H), 3.92 (s, 3 H), 3.72-3.82 (m, 1 H), 2.74-3.28 (m, 2 H), 2.47-2.64 (m, 3 H) 448.2 [M+H] + 98.8%
848 (CD 3OD) δ 8.16-8.70 (m, 1 H), 7.70 (br s, 1 H), 7.50 (s, 1 H), 6.94-7.07 (m, 1.6 H), 6.68-6.93 (m, 2 H), 6.42-6.61 (m, 1 H), 6.16 (br s, 0.4 H), 3.95 (br dd, 1 H), 3.59-3.83 (m, 1.6 H), 3.35-3.45 (m, 0.4 H), 2.89-3.11 (m, 1 H), 2.68-2.89 (m, 1 H), 1.12 (br s, 1 H), 0.63-0.99 (m, 3 H) 392.2 [M+H] + 99.6%
849 (CD 3OD) δ 8.31-8.53 (m, 1 H), 7.70 (br s, 1 H), 7.50 (s, 1 H), 6.94-7.13 (m, 1.6 H), 6.68-6.93 (m, 2 H), 6.39-6.61 (m, 1 H), 6.16 (br s, 0.4 H), 3.95 (br dd, 1 H), 3.56-3.82 (m, 1.6 H), 3.36-3.45 (m, 0.4 H), 2.89-3.11 (m, 1 H), 2.70-2.87 (m, 1 H), 1.12 (br s, 1 H), 0.64-1.01 (m, 3 H) 392.2 [M+H] + 99.1%
850 (CD 3OD) δ 8.83 (br d, 2 H), 8.19-8.36 (m, 1 H), 8.12 (d, 2 H), 7.49-7.77 (m, 1 H), 6.94-7.04 (m, 2 H), 6.72-6.85 (m, 1 H), 6.52-6.67 (m, 1 H), 5.05 (br dd, 0.5 H), 3.72-3.89 (m, 1 H), 3.37-3.51 (m, 0.5 H), 2.95-3.26 (m, 1 H), 2.88 (br s, 1 H), 2.38-2.51 (m, 3 H) 427.2 [M+H] + 100%
851 (CD 3OD) δ 8.83 (br d, 2 H), 8.19-8.38 (m, 1 H), 8.12 (d, 2 H), 7.41-7.80 (m, 1 H), 6.91-7.06 (m, 2 H), 6.71-6.84 (m, 1 H), 6.49-6.68 (m, 1 H), 5.05 (br dd, 0.5 H), 3.71-3.90 (m, 1 H), 3.43 (br t, 0.5 H), 2.97-3.27 (m, 1 H), 2.88 (br s, 1 H), 2.38-2.50 (m, 3 H) 427.2 [M+H] + 98.3%
852 (CD 3OD) δ 8.99 (s, 1 H), 8.46 (s, 1 H), 8.20-8.36 (m, 1 H), 7.54-7.71 (m, 1 H), 6.74-7.09 (m, 3 H), 6.52-6.68 (m, 1 H), 4.96-5.20 (m, 1 H), 3.79 (br t, 1 H), 3.04-3.24 (m, 2 H), 2.85 (br d, 1 H), 2.42-2.46 (m, 3 H), 1.44-1.51 (m, 2 H), 1.28 (br d, 2 H) 520.2 [M+H] + 100%
853 (CD 3OD) δ 8.99 (s, 1 H), 8.46 (s, 1 H), 8.19-8.36 (m, 1 H), 7.57-7.97 (m, 1 H), 6.50-7.20 (m, 4 H), 5.03-5.15 (m, 1 H), 3.68-3.89 (m, 1 H), 2.99-3.26 (m, 2 H), 2.88 (br d, 1 H), 2.39-2.50 (m, 3 H), 1.44-1.52 (m, 2 H), 1.28 (br d, 2 H) 520.2 [M+H] + 99.3%
854 (CD 3OD) δ 8.14-8.38 (m, 1 H), 7.48-7.73 (m, 1 H), 6.71-7.08 (m, 4 H), 6.49-6.68 (m, 1 H), 5.00 (br dd, 1 H), 3.90 (s, 3 H), 3.71-3.84 (m, 1 H), 2.94-3.23 (m, 1 H), 2.83 (br d, 1 H), 2.38-2.47 (m, 6 H) 444.2 [M+H] + 96.4%
855 (CD 3OD) δ 8.21-8.35 (m, 1 H), 7.49-7.71 (m, 1 H), 6.71-7.08 (m, 4 H), 6.50-6.67 (m, 1 H), 5.00 (br dd, 1 H), 3.90 (s, 3 H), 3.36-3.83 (m, 1 H), 2.95-3.24 (m, 1 H), 2.83 (br d, 1 H), 2.36-2.48 (m, 6 H) 444.2 [M+H] + 90.2%
856 (CD 3OD) δ 8.33-8.58 (m, 1 H), 7.47-8.01 (m, 3 H), 7.19 (br t, 1 H), 6.15-7.02 (m, 4 H), 4.69 (br d, 2 H), 3.63-4.07 (m, 1 H), 2.66-3.18 (m, 2 H), 1.22-1.57 (m, 6 H) 376.2 [M+H] + 99.9%
857 (CD 3OD) δ 8.34-8.61 (m, 1 H), 7.44-7.78 (m, 3 H), 7.19 (br t, 1 H), 6.12-7.04 (m, 4 H), 4.69 (br d, 2 H), 3.60-4.03 (m, 1 H), 2.60-3.09 (m, 2 H), 1.25-1.51 (m, 6 H) 376.2 [M+H] + 99.9%
858 (CD 3OD) δ 8.23-8.53 (m, 1 H), 7.49-7.74 (m, 2 H), 6.07-7.13 (m, 5 H), 4.55-4.82 (m, 2 H), 3.60-4.09 (m, 1 H), 2.66-3.07 (m, 2 H), 1.25-1.53 (m, 6 H) 394.2 [M+H] + 99.5%
859 (CD 3OD) δ 8.23-8.49 (m, 1 H), 7.43-7.78 (m, 2 H), 6.15-7.04 (m, 5 H), 4.54-4.80 (m, 2 H), 3.61-4.14 (m, 1 H), 2.68-3.10 (m, 2 H), 1.42 (br d, 6 H) 394.2 [M+H] + 98.6%
860 (CD 3OD) δ 8.18-8.57 (m, 1 H), 7.70 (br s, 1 H), 7.50 (d, 1 H), 6.94-7.10 (m, 1.6 H), 6.77-6.87 (m, 1 H), 6.74 (br s, 0.4 H), 6.06-6.70 (m, 2 H), 3.92 (br dd, 1 H), 3.75 (br t, 0.6 H), 3.66 (br d, 1 H), 3.36-3.48 (m, 0.4 H), 2.88-3.12 (m, 1 H), 2.70-2.87 (m, 1 H), 2.33-2.53 (m, 3 H), 0.78-1.16 (m, 4 H) 388.2 [M+H] + 98.4%
861 (CD 3OD) δ 8.23-8.56 (m, 1 H), 7.63-7.80 (m, 1 H), 7.50 (d, 1 H), 6.94-7.10 (m, 1.6 H), 6.78-6.86 (m, 1 H), 6.74 (br s, 0.4 H), 6.10-6.70 (m, 2 H), 3.92 (br dd, 1 H), 3.74 (br t, 0.6 H), 3.66 (br d, 1 H), 3.39 (br d, 0.4 H), 2.88-3.11 (m, 1 H), 2.67-2.87 (m, 1 H), 2.39-2.54 (m, 3 H), 0.77-1.16 (m, 4 H) 388.2 [M+H] + 99.2%
862 (CD 3OD) δ 8.32 (dd, 1 H), 7.66-7.89 (m, 4 H), 7.46-7.57 (m, 1 H), 7.02-7.13 (m, 1.6 H), 6.99 (s, 1 H), 6.73-6.86 (m, 1.4 H), 5.83-6.71 (m, 2 H), 3.42-3.77 (m, 2 H), 2.58-3.13 (m, 2 H), 2.36-2.51 (m, 3 H) 425.2 [M+H] + 88.7%
863 (CD 3OD) δ 8.24-8.36 (m, 1 H), 7.65-7.91 (m, 4 H), 7.44-7.56 (m, 1 H), 7.02-7.14 (m, 1.6 H), 6.94-7.00 (m, 1 H), 6.73-6.86 (m, 1.4 H), 5.83-6.72 (m, 2 H), 3.41-3.79 (m, 2 H), 2.56-3.13 (m, 2 H), 2.37-2.52 (m, 3 H) 425.2 [M+H] + 85.6%
864 (CD 3OD) δ 8.30-8.49 (m, 1 H), 7.69 (s, 1 H), 6.70-7.07 (m, 5 H), 6.28-6.65 (m, 1 H), 4.76-4.86 (m, 0.4 H), 4.03-4.18 (m, 0.6 H), 3.95 (s, 3 H), 3.72 (br t, 0.6 H), 3.26 (br s, 0.4 H), 2.90-3.05 (m, 1 H), 2.76 (br d, 1 H) 416.2 [M+H] + 100%
865 (CD 3OD) δ 8.29-8.50 (m, 1 H), 7.69 (s, 1 H), 6.73-7.06 (m, 5 H), 6.25-6.65 (m, 1 H), 4.77-4.86 (m, 0.4 H), 4.09 (br d, 0.6 H), 3.95 (s, 3 H), 3.72 (br t, 0.6 H), 3.27 (br s, 0.4 H), 2.90-3.07 (m, 1 H), 2.76 (br d, 1 H) 416.2 [M+H] + 100%
866 (CD 3OD) δ 8.25-8.42 (m, 1 H), 7.68 (s, 1 H), 6.87-7.05 (m, 2 H), 6.72-6.84 (m, 2 H), 6.62 (s, 1 H), 6.30 (br s, 1 H), 4.01-4.16 (m, 1 H), 3.94 (s, 3 H), 3.64-3.82 (m, 1 H), 2.96 (br d, 1 H), 2.76 (br d, 1 H), 2.36-2.48 (m, 3 H) 412.2 [M+H] + 98.4%
867 (CD 3OD) δ 8.26-8.42 (m, 1 H), 7.68 (s, 1 H), 6.86-7.06 (m, 2 H), 6.71-6.82 (m, 2 H), 6.62 (s, 1 H), 6.31 (br s, 1 H), 4.00-4.15 (m, 1 H), 3.94 (s, 3 H), 3.65-3.82 (m, 1 H), 2.96 (br d, 1 H), 2.76 (br d, 1 H), 2.34-2.50 (m, 3 H) 412.2 [M+H] + 97.6%
868 (CD 3OD) δ 8.47 (br s, 1 H), 7.49-7.99 (m, 4 H), 7.03-7.38 (m, 2 H), 6.43-6.96 (m, 3 H), 4.47 (br s, 1 H), 3.87-4.17 (m, 3 H), 3.37-3.85 (m, 1 H), 2.74-3.23 (m, 2 H) 465.2 [M+H] + 99.6%
869 (CD 3OD) δ 8.47 (br s, 1 H), 7.47-8.01 (m, 4 H), 7.04-7.38 (m, 2 H), 6.51-6.97 (m, 3 H), 4.44 (br s, 1 H), 3.91-4.17 (m, 3 H), 3.37-3.84 (m, 1 H), 2.74-3.22 (m, 2 H) 465.2 [M+H] + 99.7%
870 (CD 3OD) δ 8.60 (s, 1 H), 8.14-8.34 (m, 2 H), 7.89 (br d, 1 H), 7.45-7.73 (m, 1 H), 6.92-7.03 (m, 2 H), 6.70-6.83 (m, 1 H), 6.53-6.66 (m, 1 H), 4.99 (br dd, 1 H), 3.72-3.86 (m, 0.7 H), 3.36-3.49 (m, 0.3 H), 3.13-3.25 (m, 0.7 H), 2.95-3.06 (m, 0.3 H), 2.80-2.94 (m, 1 H), 2.38-2.50 (m, 6 H) 441.2 [M+H] + 100%
871 (CD 3OD) δ 8.61 (s, 1 H), 8.15-8.33 (m, 2 H), 7.90 (br d, 1 H), 7.46-7.73 (m, 1 H), 6.93-7.04 (m, 2 H), 6.71-6.84 (m, 1 H), 6.54-6.69 (m, 1 H), 4.99 (br dd, 1 H), 3.72-3.87 (m, 0.7 H), 3.37-3.51 (m, 0.3 H), 3.14-3.24 (m, 0.7 H), 2.94-3.07 (m, 0.3 H), 2.84 (br d, 1 H), 2.38-2.51 (m, 6 H) 441.2 [M+H] + 99.7%
872 (CD 3OD) δ 9.11 (s, 1 H), 8.46-8.55 (m, 1 H), 8.38-8.45 (m, 1 H), 8.19-8.34 (m, 1 H), 7.46-7.75 (m, 1 H), 6.91-7.04 (m, 2 H), 6.70-6.84 (m, 1 H), 6.55-6.67 (m, 1 H), 5.00 (br dd, 1 H), 3.75-3.85 (m, 0.7 H), 3.43 (td, 0.4 H), 2.95-3.26 (m, 1 H), 2.79-2.90 (m, 1 H), 2.36-2.50 (m, 3 H) 495.2 [M+H] + 100%
873 (CD 3OD) δ 9.11 (s, 1 H), 8.45-8.53 (m, 1 H), 8.36-8.44 (m, 1 H), 8.20-8.33 (m, 1 H), 7.66-7.78 (m, 1 H), 7.51 (s, 0.3 H), 6.91-7.05 (m, 1.7 H), 6.71-6.84 (m, 1 H), 6.55-6.68 (m, 1 H), 5.01 (br dd, 1 H), 3.70-3.87 (m, 0.7 H), 3.39-3.51 (m, 0.3 H), 2.95-3.26 (m, 1 H), 2.79-2.91 (m, 1 H), 2.37-2.52 (m, 3 H) 495.2 [M+H] + 100%
874 (CD 3OD) δ 8.69 (d, 1 H), 8.21-8.40 (m, 2 H), 7.87 (td, 1 H), 7.46-7.75 (m, 1 H), 6.93-7.02 (m, 2 H), 6.71-6.82 (m, 1 H), 6.55-6.67 (m, 1 H), 5.00 (br dd, 1 H), 3.72-3.86 (m, 0.7 H), 3.43 (td, 0.3 H), 3.13-3.25 (m, 0.7 H), 2.95-3.07 (m, 0.3 H), 2.78-2.89 (m, 1 H), 2.39-2.47 (m, 3 H) 445.2 [M+H] + 100%
875 (CD 3OD) δ 8.69 (d, 1 H), 8.19-8.40 (m, 2 H), 7.87 (td, 1 H), 7.45-7.74 (m, 1 H), 6.89-7.04 (m, 2 H), 6.71-6.83 (m, 1 H), 6.53-6.67 (m, 1 H), 5.00 (br dd, 1 H), 3.72-3.85 (m, 0.7 H), 3.43 (td, 0.3 H), 3.12-3.26 (m, 0.7 H), 2.94-3.07 (m, 0.3 H), 2.78-2.89 (m, 1 H), 2.38-2.46 (m, 3 H) 445.2 [M+H] + 99.4%
876 (CD 3OD) δ 8.62 (s, 1 H), 8.27-8.38 (m, 1 H), 8.15-8.23 (m, 1 H), 7.90 (br d, 1 H), 7.70 (s, 1 H), 7.50 (s, 0.3 H), 7.18 (br s, 0.2 H), 6.92-7.00 (m, 1.5 H), 6.75-6.87 (m, 2 H), 5.02 (br dd, 1 H), 3.76-3.85 (m, 0.7 H), 3.37-3.50 (m, 0.3 H), 2.78-3.26 (m, 2 H), 2.48 (s, 3 H) 445.2 [M+H] + 100%
877 (CD 3OD) δ 8.62 (s, 1 H), 8.26-8.39 (m, 1 H), 8.15-8.23 (m, 1 H), 7.87-7.94 (m, 1 H), 7.70 (s, 1 H), 7.50 (s, 0.3 H), 7.20 (br s, 0.2 H), 6.93-7.00 (m, 1.5 H), 6.75-6.87 (m, 2 H), 5.02 (br dd, 1 H), 3.74-3.85 (m, 0.6 H), 3.36-3.49 (m, 0.4 H), 2.80-3.25 (m, 2 H), 2.48 (s, 3 H) 445.2 [M+H] + 100%
878 (CD 3OD) δ 9.11 (s, 1 H), 8.23-8.56 (m, 3 H), 7.43-7.78 (m, 1.3 H), 6.90-7.07 (m, 1.7 H), 6.74-6.88 (m, 2 H), 4.94-5.06 (m, 1 H), 3.75-3.86 (m, 0.7 H), 3.43 (td, 0.3 H), 2.81-3.27 (m, 2 H) 499.2 [M+H] + 100%
879 (CD 3OD) δ 9.11 (s, 1 H), 8.23-8.57 (m, 3 H), 7.46-7.78 (m, 1.3 H), 6.90-7.04 (m, 1.7 H), 6.71-6.87 (m, 2 H), 4.94-5.07 (m, 1 H), 3.75-3.87 (m, 0.6 H), 3.44 (td, 0.4 H), 2.82-3.25 (m, 2 H) 499.2 [M+H] + 100%
880 (CD 3OD) δ 8.70 (d, 1 H), 8.23-8.44 (m, 2 H), 7.88 (td, 1 H), 7.70 (s, 1 H), 7.51 (s, 0.3 H), 6.91-7.04 (m, 1.7 H), 6.72-6.89 (m, 2 H), 4.93-5.08 (m, 1 H), 3.79 (ddd, 0.7 H), 3.43 (td, 0.3 H), 2.81-3.25 (m, 2 H) 449.2 [M+H] + 100%
881 (CD 3OD) δ 8.70 (d, 1 H), 8.24-8.43 (m, 2 H), 7.88 (td, 1 H), 7.70 (s, 1 H), 7.51 (s, 0.3 H), 6.90-7.03 (m, 1.7 H), 6.73-6.88 (m, 2 H), 4.94-5.07 (m, 1 H), 3.73-3.86 (m, 0.7 H), 3.43 (td, 0.3 H), 2.79-3.25 (m, 2 H) 449.2 [M+H] + 100%
882 (CD 3OD) δ 8.20-8.41 (m, 1 H), 7.44-7.77 (m, 1 H), 6.66-7.11 (m, 5 H), 5.02 (br dd, 1 H), 3.90 (s, 3 H), 3.68-3.85 (m, 1 H), 2.81-3.25 (m, 2 H), 2.39 (s, 3 H) 448.2 [M+H]+ 99.7%
883 (CD 3OD) δ 8.20-8.43 (m, 1 H), 7.47-7.76 (m, 1 H), 6.62-7.12 (m, 5 H), 5.02 (br dd, 1 H), 3.90 (s, 3 H), 3.71-3.84 (m, 1 H), 2.76-3.24 (m, 2 H), 2.39 (s, 3 H) 448.2 [M+H] + 99.4%
884 (CD 3OD) δ 8.32-8.47 (m, 1 H), 7.68 (s, 1 H), 7.52 (br s, 1 H), 6.91-7.01 (m, 1.5 H), 6.72-6.89 (m, 2 H), 6.30-6.64 (m, 1.5 H), 4.11 (br d, 1 H), 3.47-3.97 (m, 4 H), 2.71-3.02 (m, 2 H) 366.2 [M+H] + 99.8%
885 (CD 3OD) δ 8.29-8.49 (m, 1 H), 7.69 (s, 1 H), 7.53 (br s, 1 H), 6.91-7.02 (m, 1.5 H), 6.73-6.89 (m, 2 H), 6.31-6.63 (m, 1.5 H), 4.10 (br s, 1 H), 3.93 (s, 4 H), 2.71-3.04 (m, 2 H) 366.2 [M+H] + 99.6%
886 (CD 3OD) δ 8.02-8.21 (m, 1 H), 7.34-7.72 (m, 1 H), 6.86-7.06 (m, 1 H), 6.73-6.85 (m, 2 H), 6.53-6.68 (m, 2 H), 6.31 (br d, 1 H), 4.72-4.85 (m, 1 H), 4.05 (br d, 0.5 H), 3.90-3.98 (m, 6 H), 3.70 (br t, 0.5 H), 2.97 (br s, 1 H), 2.67-2.83 (m, 1 H) 428.2 [M+H] + 99.1%
887 (CD 3OD) δ 8.04-8.20 (m, 1 H), 7.67 (s, 1 H), 6.87-7.06 (m, 1 H), 6.71-6.84 (m, 2 H), 6.64 (br d, 1 H), 6.57 (d, 1 H), 6.31 (br d, 1 H), 4.76-4.83 (m, 0.4 H), 4.00-4.13 (m, 0.6 H), 3.89-3.98 (m, 6 H), 3.70 (br t, 0.7 H), 3.27 (br s, 0.3 H), 2.90-3.04 (m, 1 H), 2.68-2.82 (m, 1 H) 428.2 [M+H] + 99.1%
888 (CD 3OD) δ 8.36 (br s, 1 H), 7.45-8.01 (m, 3 H), 7.03-7.36 (m, 1 H), 6.58-7.03 (m, 4 H), 4.47 (br d, 1 H), 3.92-4.16 (m, 3 H), 3.36-3.85 (m, 1 H), 2.74-3.22 (m, 2 H) 483.2 [M+H] + 99.3%
889 (CD 3OD) δ 8.36 (br s, 1 H), 7.49-8.01 (m, 3 H), 7.03-7.39 (m, 1 H), 6.60-7.03 (m, 4 H), 4.46 (br s, 1 H), 3.90-4.17 (m, 3 H), 3.37-3.86 (m, 1 H), 2.74-3.22 (m, 2 H) 483.2 [M+H] + 99.6%
890 (CD 3OD) δ 8.32 (br d, 1 H), 7.48-8.00 (m, 3 H), 6.94-7.38 (m, 2 H), 6.48-6.93 (m, 3 H), 4.47 (br s, 1 H), 3.90-4.16 (m, 3 H), 3.39-3.88 (m, 1 H), 2.74-3.25 (m, 2 H), 2.45 (s, 3 H) 479.3 [M+H] + 99.5%
891 (CD 3OD) δ 8.31 (br d, 1 H), 7.45-7.98 (m, 3 H), 6.96-7.38 (m, 2 H), 6.50-6.94 (m, 3 H), 4.46 (br s, 1 H), 3.90-4.16 (m, 3 H), 3.37-3.85 (m, 1 H), 2.74-3.21 (m, 2 H), 2.44 (s, 3 H) 479.2 [M+H] + 99.7%
892 (CD 3OD) δ 8.28-8.65 (m, 1 H), 7.43-7.78 (m, 2 H), 7.21 (dd, 1 H), 6.80-7.04 (m, 1.5 H), 6.49-6.74 (m, 1 H), 6.36 (br s, 1.3 H), 4.80-4.87 (m, 0.8 H), 4.05-4.21 (m, 0.5 H), 3.84 (s, 3 H), 3.70 (br t, 0.5 H), 2.66-3.04 (m, 2 H), 2.20-2.36 (m, 3 H) 362.2 [M+H] + 100%
893 (CD 3OD) δ 8.11-8.58 (m, 1 H), 7.28-7.70 (m, 2 H), 6.89-7.25 (m, 1 H), 6.66-6.88 (m, 1.5 H), 6.30-6.63 (m, 1 H), 6.23 (br s, 1.3 H), 4.65-4.76 (m, 1 H), 3.92-4.08 (m, 0.5 H), 3.53-3.77 (m, 3.5 H), 2.52-2.97 (m, 2 H), 2.02-2.24 (m, 3 H) 362.2 [M+H] + 99.7%
894 (CD 3OD) δ 9.31 (d, 1 H), 8.80 (dd, 1 H), 8.55 (dd, 1 H), 8.18-8.36 (m, 1 H), 7.63-7.74 (m, 2 H), 7.56 (s, 0.3 H), 6.94-7.04 (m, 1.7 H), 6.72-6.84 (m, 1 H), 6.53-6.67 (m, 1 H), 5.07 (dd, 1 H), 3.80 (ddd, 0.6 H), 3.37-3.51 (m, 0.4 H), 2.95-3.26 (m, 1 H), 2.76-2.92 (m, 1 H), 2.38-2.48 (m, 3 H) 427.2 [M+H] + 100%
895 (CD 3OD) δ 9.31 (d, 1 H), 8.80 (dd, 1 H), 8.55 (dt, 1 H), 8.20-8.35 (m, 1 H), 7.63-7.74 (m, 2 H), 7.56 (s, 0.3 H), 6.91-7.03 (m, 1.7 H), 6.72-6.85 (m, 1 H), 6.53-6.67 (m, 1 H), 5.07 (dd, 1 H), 3.76-3.86 (m, 0.6 H), 3.44 (td, 0.4 H), 2.95-3.26 (m, 1 H), 2.79-2.90 (m, 1 H), 2.37-2.50 (m, 3 H) 427.2 [M+H] + 99.3%
896 (CD 3OD) δ 9.31 (d, 1 H), 8.80 (dd, 1 H), 8.49-8.62 (m, 1 H), 8.24-8.42 (m, 1 H), 7.66-7.71 (m, 2 H), 7.57 (s, 0.3 H), 6.93-7.01 (m, 1.7 H), 6.73-6.88 (m, 2 H), 4.96-5.15 (m, 1 H), 3.75-3.86 (m, 0.7 H), 3.38-3.52 (m, 0.3 H), 2.82-3.23 (m, 2 H) 431.2 [M+H] + 99.8%
897 (CD 3OD) δ 9.31 (d, 1 H), 8.80 (dd, 1 H), 8.55 (dd, 1 H), 8.28-8.39 (m, 1 H), 7.65-7.73 (m, 2 H), 7.57 (s, 0.3 H), 6.90-7.03 (m, 1.7 H), 6.72-6.89 (m, 2 H), 5.10 (dd, 1 H), 3.72-3.87 (m, 0.7 H), 3.40-3.49 (m, 0.3 H), 2.81-3.24 (m, 2 H) 431.1 [M+H] + 98.3%
898 (CD 3OD) δ 8.05-8.17 (m, 1 H), 7.52-7.95 (m, 5 H), 7.08-7.21 (m, 1 H), 6.60-7.02 (m, 4 H), 5.84-6.59 (m, 1 H), 3.94-4.06 (m, 3 H), 3.37-3.83 (m, 2 H), 2.57-3.18 (m, 2 H) 441.2 [M+H] + 100%
899 (CD 3OD) δ 8.01-8.16 (m, 1 H), 7.48-7.95 (m, 5 H), 7.04-7.21 (m, 1 H), 6.59-6.99 (m, 4 H), 5.82-6.57 (m, 1 H), 3.89-4.06 (m, 3 H), 3.39-3.80 (m, 2 H), 2.56-3.15 (m, 2 H) 441.2 [M+H] + 92.8%
900 (CD 3OD) δ 8.13-8.49 (m, 1 H), 7.65 (s, 1 H), 6.83-7.18 (m, 2 H), 6.75 (br s, 1 H), 6.44-6.63 (m, 1 H), 6.31 (br t, 1 H), 4.02-4.16 (m, 1 H), 3.80 (s, 3 H), 3.68 (br t, 1 H), 2.65-3.05 (m, 2 H), 2.33-2.48 (m, 3 H), 2.23 (br s, 3 H) 376.2 [M+H] + 100%
901 (CD 3OD) δ 8.20-8.42 (m, 1 H), 7.65 (s, 1 H), 6.87-7.07 (m, 2 H), 6.76 (br s, 1 H), 6.37-6.62 (m, 1 H), 6.19-6.36 (m, 1 H), 3.97-4.18 (m, 1 H), 3.54-3.86 (m, 4 H), 2.65-3.04 (m, 2 H), 2.33-2.48 (m, 3 H), 2.23 (br s, 3 H) 376.2 [M+H] + 99.3%
902 (CD 3OD) δ 7.83-8.43 (m, 3 H), 7.68 (s, 1 H), 7.02-7.36 (m, 1 H), 6.93-7.00 (m, 1 H), 6.61-6.90 (m, 3 H), 4.36-4.61 (m, 1 H), 3.97 (br s, 3 H), 3.76 (br s, 0.6 H), 3.36-3.51 (m, 0.4 H), 2.72-3.23 (m, 2 H) 483.2 [M+H] + 99.3%
903 (CD 3OD) δ 7.74-8.32 (m, 3 H), 7.59 (s, 1 H), 6.93-7.25 (m, 1 H), 6.87 (dd, 1 H), 6.51-6.79 (m, 3 H), 4.31-4.51 (m, 1 H), 3.87 (br s, 3 H), 3.66 (br s, 0.6 H), 3.24-3.43 (m, 0.4 H), 2.61-3.13 (m, 2 H) 483.2 [M+H] + 98.9%
904 (CD 3OD) δ 8.62-8.74 (m, 2 H), 7.88-8.08 (m, 2 H), 7.53-7.78 (m, 2 H), 6.84-7.07 (m, 3 H), 5.05 (br dd, 1 H), 3.40-3.82 (m, 1 H), 3.00-3.28 (m, 1 H), 2.86-2.95 (m, 1 H) 499.2 [M+H]+ 99.0%
905 (CD 3OD) δ 8.62-8.72 (m, 2 H), 7.46-7.96 (m, 4 H), 6.81-7.02 (m, 3 H), 4.98 (br dd, 1 H), 3.39-3.83 (m, 1 H), 2.98-3.27 (m, 1 H), 2.86 (br dd, 1 H) 499.2 [M+H]+ 94.9%
906 (CD 3OD) δ 8.89-8.94 (m, 1 H), 8.64-8.71 (m, 1 H), 8.30-8.38 (m, 1 H), 7.50-7.80 (m, 3.5 H), 6.77-7.01 (m, 2.5 H), 4.95-5.13 (m, 1 H), 3.36-3.81 (m, 1 H), 2.95-3.23 (m, 1 H), 2.80-2.89 (m, 1 H) 520.2 [M+H] + 100%
907 (CD 3OD) δ 8.90-8.94 (m, 1 H), 8.64-8.71 (m, 1 H), 8.26-8.41 (m, 1 H), 7.49-7.82 (m, 3.5 H), 6.77-7.02 (m, 2.5 H), 4.95-5.13 (m, 1 H), 3.39-3.82 (m, 1 H), 2.95-3.22 (m, 1 H), 2.79-2.89 (m, 1 H) 520.2 [M+H]+ 95.7%
908 (CD 3OD) δ 8.62-8.73 (m, 1 H), 8.33 (d, 1 H), 7.50-7.84 (m, 3 H), 6.74-7.24 (m, 4 H), 4.95-5.09 (m, 1 H), 3.36-3.82 (m, 1 H), 2.96-3.25 (m, 1 H), 2.79-2.90 (m, 1 H) 520.2 [M+H]+ 100%
909 (CD 3OD) δ 8.62-8.73 (m, 1 H), 8.33 (d, 1 H), 7.52-7.83 (m, 3 H), 6.76-7.22 (m, 4 H), 4.94-5.09 (m, 1 H), 3.36-3.83 (m, 1 H), 2.97-3.24 (m, 1 H), 2.79-2.92 (m, 1 H) 520.2 [M+H]+ 100%
910 (CD 3OD) δ 8.41-8.47 (m, 1 H), 8.25 (dd, 1 H), 7.56-7.73 (m, 2 H), 7.41-7.52 (m, 1.5 H), 6.98-7.15 (m, 1.5 H), 6.58-6.76 (m, 1.6 H), 6.44 (s, 0.4 H), 4.94-5.06 (m, 1 H), 3.99 (d, 3.7 H), 3.35-3.42 (m, 0.3 H), 2.82-3.24 (m, 2 H), 2.45-2.71 (m, 3 H) 457.2 [M+H] + 100%
911 (CD 3OD) δ 8.39-8.49 (m, 1 H), 8.25 (dd, 1 H), 7.56-7.76 (m, 2 H), 7.39-7.53 (m, 1.5 H), 6.97-7.18 (m, 1.5 H), 6.59-6.76 (m, 1.6 H), 6.44 (s, 0.4 H), 4.94-5.06 (m, 1 H), 3.99 (d, 3.6 H), 3.36-3.42 (m, 0.4 H), 2.80-3.24 (m, 2 H), 2.44-2.70 (m, 3 H) 457.2 [M+H] + 100%
912 (CD 3OD) δ 8.58-8.69 (m, 1 H), 7.87-7.99 (m, 1 H), 7.64-7.80 (m, 2 H), 7.36-7.52 (m, 1.4 H), 6.95-7.19 (m, 1.6 H), 6.58-6.76 (m, 1.6 H), 6.44 (s, 0.4 H), 4.93-4.99 (m, 1 H), 3.86-4.00 (m, 0.6 H), 3.34-3.42 (m, 0.4 H), 2.81-3.26 (m, 2 H), 2.44-2.70 (m, 3 H) 445.2 [M+H] + 100%
913 (CD 3OD) δ 8.64 (t, 1 H), 7.86-8.00 (m, 1 H), 7.60-7.80 (m, 2 H), 7.35-7.53 (m, 1.5 H), 6.93-7.18 (m, 1.5 H), 6.55-6.80 (m, 1.6 H), 6.44 (s, 0.4 H), 4.93-5.01 (m, 1 H), 3.93 (br t, 0.5 H), 3.34-3.44 (m, 0.5 H), 2.79-3.25 (m, 2 H), 2.41-2.75 (m, 3 H) 445.2 [M+H] + 100%
914 (CD 3OD) δ 8.92 (d, 1 H), 8.35 (s, 1 H), 7.39-7.84 (m, 3.5 H), 6.94-7.19 (m, 1.5 H), 6.40-6.77 (m, 2 H), 4.92-5.10 (m, 1 H), 3.85-3.99 (m, 0.6 H), 3.35-3.44 (m, 0.4 H), 2.81-3.23 (m, 2 H), 2.47-2.74 (m, 3 H) 466.2 [M+H] + 100%
915 (CD 3OD) δ 8.92 (d, 1 H), 8.35 (s, 1 H), 7.40-7.86 (m, 3.5 H), 6.90-7.22 (m, 1.5 H), 6.40-6.77 (m, 2 H), 4.93-5.11 (m, 1 H), 3.87-3.99 (m, 0.6 H), 3.34-3.44 (m, 0.4 H), 2.81-3.21 (m, 2 H), 2.46-2.72 (m, 3 H) 466.2 [M+H] + 100%
916 (CD 3OD) δ 8.28-8.36 (m, 1 H), 7.70 (d, 1 H), 6.74-7.08 (m, 3 H), 6.23-6.68 (m, 1 H), 4.93 (br s, 0.4 H), 4.36 (dd, 0.6 H), 3.96 (d, 3 H), 3.65-3.75 (m, 0.6 H), 3.26 (td, 0.4 H), 2.93-3.19 (m, 1 H), 2.72-2.88 (m, 1 H), 2.36-2.49 (m, 6 H) 377.2 [M+H] + 99.7%
917 (CD 3OD) δ 8.27-8.38 (m, 1 H), 7.70 (d, 1 H), 6.73-7.07 (m, 3 H), 6.22-6.66 (m, 1 H), 4.93 (br s, 0.4 H), 4.36 (dd, 0.6H), 3.96 (d, 3 H), 3.70 (ddd, 0.6 H), 3.26 (td, 0.4 H), 2.93-3.18 (m, 1 H), 2.71-2.88 (m, 1 H), 2.34-2.51 (m, 6 H) 377.2 [M+H] + 99.1%
918 (CD 3OD) δ 8.06-8.22 (m, 1 H), 7.69 (s, 1 H), 6.94 (br s, 0.6 H), 6.75-6.86 (m, 1 H), 6.46-6.72 (m, 2 H), 6.35 (br s, 1.4 H), 4.78-4.87 (m, 1 H), 4.04-4.19 (m, 0.5 H), 3.97 (br s, 3 H), 3.83 (s, 3 H), 3.62-3.75 (m, 0.5 H), 2.66-3.06 (m, 2 H), 2.27 (br s, 3 H) 392.2 [M+H] + 98.8%
919 (CD 3OD) δ 7.95-8.35 (m, 1 H), 7.69 (br s, 1 H), 6.94 (br s, 0.6 H), 6.80 (br s, 1 H), 6.47-6.73 (m, 2 H), 6.35 (br s, 1.4 H), 4.79-4.87 (m, 0.7 H), 4.12 (br d, 0.5 H), 3.97 (br s, 3 H), 3.83 (s, 3 H), 3.61-3.77 (m, 0.5 H), 3.24-3.32 (m, 0.3 H), 2.56-3.16 (m, 2 H), 2.27 (br s, 3 H) 392.2 [M+H] + 98.3%
920 (CD 3OD) δ 8.34 (d, 1 H), 7.56-8.05 (m, 3 H), 7.03-7.37 (m, 1 H), 6.68-7.02 (m, 4 H), 4.46-4.59 (m, 1 H), 3.83 (br s, 4 H), 2.79-3.25 (m, 2 H) 483.2 [M+H] + 99.0%
921 (CD 3OD) δ 8.34 (d, 1 H), 7.63-8.01 (m, 3 H), 7.04-7.45 (m, 1 H), 6.70-7.02 (m, 4 H), 4.44-4.59 (m, 1 H), 3.65-3.90 (m, 4 H), 2.74-3.25 (m, 2 H) 483.2 [M+H] + 96.9%
922 (CD 3OD) δ 8.08-8.25 (m, 1 H), 7.59 (s, 1 H), 7.30 (s, 0.3 H), 6.80-6.93 (m, 1.7 H), 6.61-6.75 (m, 1 H), 6.35-6.59 (m, 1 H), 4.80-4.87 (m, 1 H), 3.65 (ddd, 0.7 H), 3.29 (td, 0.3 H), 2.82-3.11 (m, 1 H), 2.72 (dd, 1 H), 2.28-2.37 (m, 3 H), 1.72-1.84 (m, 6 H) 410.2 [M+H] + 100%
923 (CD 3OD) δ 8.22-8.34 (m, 1 H), 7.69 (s, 1 H), 7.40 (s, 0.3 H), 6.90-7.03 (m, 1.7 H), 6.72-6.82 (m, 1 H), 6.46-6.66 (m, 1 H), 4.90-4.98 (m, 1 H), 3.68-3.80 (m, 0.7 H), 3.39 (td, 0.3 H), 2.92-3.21 (m, 1 H), 2.83 (br dd, 1 H), 2.38-2.48 (m, 3 H), 1.81-1.95 (m, 6 H) 410.2 [M+H] + 99.6%
924 (CD 3OD) δ 8.23-8.33 (m, 1 H), 7.68 (s, 1 H), 7.45 (s, 0.3 H), 6.94-7.02 (m, 1 H), 6.91 (s, 0.7 H), 6.70-6.83 (m, 1 H), 6.48-6.65 (m, 1 H), 4.97 (dd, 1 H), 3.72 (ddd, 0.7 H), 3.33-3.41 (m, 0.3 H), 2.89-3.19 (m, 1 H), 2.74-2.86 (m, 1 H), 2.38-2.47 (m, 3 H), 2.24-2.36 (m, 1 H), 1.14-1.32 (m, 4 H) 390.2 [M+H] + 100%
925 (CD 3OD) δ 8.22-8.33 (m, 1 H), 7.68 (s, 1 H), 7.45 (s, 0.3 H), 6.95-7.03 (m, 1 H), 6.91 (s, 0.7 H), 6.71-6.82 (m, 1 H), 6.47-6.64 (m, 1 H), 4.97 (dd, 1 H), 3.72 (ddd, 0.7 H), 3.37 (td, 0.3 H), 2.89-3.19 (m, 1 H), 2.70-2.87 (m, 1 H), 2.37-2.51 (m, 3 H), 2.21-2.36 (m, 1 H), 1.11-1.32 (m, 4 H) 390.2 [M+H] + 99.9%
926 (CD 3OD) δ 8.18-8.37 (m, 1 H), 7.70 (s, 1 H), 7.45-7.50 (m, 1 H), 6.70-7.10 (m, 3 H), 6.55-6.67 (m, 1 H), 5.06 (dd, 1 H), 4.19-4.27 (m, 3 H), 3.76-3.86 (m, 0.7 H), 3.38-3.49 (m, 0.3 H), 2.77-3.28 (m, 2 H), 2.34-2.46 (m, 6 H) 444.2 [M+H] + 100%
927 (CD 3OD) δ 8.21-8.38 (m, 1 H), 7.70 (s, 1 H), 7.43-7.53 (m, 1 H), 6.70-7.10 (m, 3 H), 6.55-6.68 (m, 1 H), 5.06 (br dd, 1 H), 4.17-4.28 (m, 3 H), 3.66-3.84 (m, 0.7 H), 3.38-3.49 (m, 0.3 H), 2.96-3.27 (m, 1 H), 2.80-2.90 (m, 1 H), 2.33-2.46 (m, 6 H) 444.2 [M+H] + 100%
928 (CD 3OD) δ 8.25-8.39 (m, 1 H), 7.70 (s, 1 H), 7.43-7.51 (m, 1 H), 6.79-7.15 (m, 3 H), 6.73-6.78 (m, 1 H), 5.09 (dd, 0.6 H), 4.20-4.25 (m, 3 H), 3.65-3.85 (m, 1 H), 3.35-3.46 (m, 0.4 H), 2.96-3.26 (m, 1 H), 2.79-2.88 (m, 1 H), 2.29-2.48 (m, 3 H) 448.2 [M+H] + 100%
929 (CD 3OD) δ 8.26-8.41 (m, 1 H), 7.70 (s, 1 H), 7.38-7.59 (m, 1 H), 6.78-7.12 (m, 3 H), 6.73-6.78 (m, 1 H), 4.92-5.12 (m, 1 H), 4.18-4.28 (m, 3 H), 3.72-3.88 (m, 0.7 H), 3.37-3.50 (m, 0.3 H), 2.77-3.26 (m, 2 H), 2.28-2.45 (m, 3 H) 448.2 [M+H] + 100%
930 (CD 3OD) δ 8.30 (br d, 1 H), 7.63-8.08 (m, 3 H), 6.36-7.44 (m, 5 H), 4.53 (br s, 1 H), 3.82 (br s, 4 H), 2.72-3.26 (m, 2 H), 2.45 (s, 3 H) 479.2 [M+H] + 99.3%
931 (CD 3OD) δ 8.30 (d, 1 H), 7.51-8.10 (m, 3 H), 6.46-7.40 (m, 5 H), 4.51 (br s, 1 H), 3.82 (br s, 4 H), 2.78-3.26 (m, 2 H), 2.45 (s, 3 H) 479.3 [M+H] + 97.7%
932 (CD 3OD) δ 8.63-8.72 (m, 1 H), 8.43 (d, 1 H), 8.25 (d, 1 H), 7.71 (s, 1 H), 7.58-7.65 (m, 2 H), 6.91-7.04 (m, 2 H), 6.77-6.83 (m, 1 H), 4.93-5.09 (m, 1 H), 3.98 (s, 3 H), 3.37-3.83 (m, 1 H), 2.96-3.25 (m, 1 H), 2.85 (br dd, 1 H) 511.2 [M+H] + 100%
933 (CD 3OD) δ 8.62-8.72 (m, 1 H), 8.43 (d, 1 H), 8.24 (d, 1 H), 7.71 (s, 1 H), 7.56-7.66 (m, 2 H), 6.89-7.05 (m, 2 H), 6.74-6.83 (m, 1 H), 4.93-5.09 (m, 1 H), 3.98 (s, 3 H), 3.37-3.83 (m, 1 H), 2.96-3.25 (m, 1 H), 2.79-2.91 (m, 1 H) 511.2 [M+H]+ 94.9%
934 (CD 3OD) δ 8.62-8.72 (m, 1 H), 7.97 (s, 1 H), 7.76-7.87 (m, 1 H), 7.59-7.71 (m, 2 H), 6.88-7.06 (m, 2 H), 6.76-6.84 (m, 1 H), 4.92-5.13 (m, 1 H), 4.07-4.11 (m, 3 H), 3.37-3.83 (m, 1 H), 2.96-3.23 (m, 1 H), 2.78-2.90 (m, 1 H) 484.2 [M+H]+ 100%
935 (CD 3OD) δ 8.63-8.73 (m, 1 H), 7.97 (s, 1 H), 7.79-7.88 (m, 1 H), 7.70 (s, 1 H), 7.59-7.66 (m, 1 H), 6.91-7.02 (m, 2 H), 6.76-6.83 (m, 1 H), 4.93-5.13 (m, 1 H), 4.08-4.11 (m, 3 H), 3.38-3.83 (m, 1 H), 2.96-3.24 (m, 1 H), 2.79-2.89 (m, 1 H) 484.2 [M+H]+ 92.0%
936 (CD 3OD) δ 8.33 (dd, 1 H), 7.83 (d, 0.2 H), 7.64-7.75 (m, 1.5 H), 7.37-7.55 (m, 1.8 H), 7.21 (t, 1 H), 7.03-7.15 (m, 1 H), 6.99 (s, 0.5 H), 6.58-6.76 (m, 1.6 H), 6.43 (s, 0.4 H), 4.92-5.06 (m, 1 H), 3.85-3.98 (m, 0.5 H), 3.33-3.41 (m, 0.5 H), 2.80-3.24 (m, 2 H), 2.44-2.72 (m, 3 H) 466.2 [M+H] + 100%
937 (CD 3OD) δ 8.33 (dd, 1 H), 7.83 (d, 0.3 H), 7.62-7.75 (m, 1.5 H), 7.37-7.57 (m, 1.7 H), 7.21 (t, 1 H), 7.03-7.17 (m, 1 H), 6.99 (s, 0.5 H), 6.57-6.79 (m, 1.6 H), 6.44 (s, 0.4 H), 4.93-5.07 (m, 1 H), 3.86-3.98 (m, 0.5 H), 3.34-3.41 (m, 0.5 H), 2.80-3.24 (m, 2 H), 2.44-2.72 (m, 3 H) 466.2 [M+H] + 99.5%
938 (CD 3OD) δ 7.68 (d, 1 H), 7.27-7.53 (m, 1.4 H), 7.04-7.16 (m, 1 H), 6.96 (s, 0.6 H), 6.39-6.76 (m, 2 H), 4.90-4.97 (m, 1 H), 3.89 (br t, 1 H), 2.79-3.20 (m, 2 H), 2.53-2.72 (m, 3 H), 1.81-1.95 (m, 6 H) 410.2 [M+H] + 100%
939 (CD 3OD) δ 7.68 (d, 1 H), 7.29-7.52 (m, 1.4 H), 7.06-7.17 (m, 1 H), 6.96 (s, 0.6 H), 6.36-6.75 (m, 2 H), 4.90-4.94 (m, 1 H), 3.82-3.96 (m, 1 H), 2.78-3.20 (m, 2 H), 2.54-2.71 (m, 3 H), 1.80-1.95 (m, 6 H) 410.2 [M+H] + 99.1%
940 (CD 3OD) δ 7.66 (d, 1 H), 7.32-7.51 (m, 1.4 H), 7.06-7.16 (m, 1 H), 6.93 (br s, 0.6 H), 6.36-6.76 (m, 2 H), 4.97 (br dd, 1 H), 3.78-3.95 (m, 0.5 H), 3.33-3.38 (m, 0.5 H), 2.75-3.19 (m, 2 H), 2.55-2.73 (m, 3 H), 2.31 (tq, 1 H), 1.13-1.32 (m, 4 H) 390.2 [M+H] + 100%
941 (CD 3OD) δ 7.66 (d, 1 H), 7.28-7.54 (m, 1.4 H), 7.04-7.17 (m, 1 H), 6.94 (s, 0.6 H), 6.38-6.77 (m, 2 H), 4.97 (br dd, 1 H), 3.81-3.93 (m, 0.5 H), 3.34-3.40 (m, 0.5 H), 2.76-3.17 (m, 2 H), 2.56-2.72 (m, 3 H), 2.24-2.37 (m, 1 H), 1.10-1.40 (m, 4 H) 390.2 [M+H] + 99.9%
942 (CD 3OD) δ 8.62-8.72 (m, 1 H), 7.69 (s, 1 H), 7.59-7.65 (m, 1 H), 6.84-7.04 (m, 2 H), 6.70-6.80 (m, 1 H), 4.89-5.05 (m, 1 H), 3.35-3.77 (m, 1 H), 2.92-3.16 (m, 1 H), 2.76-2.86 (m, 1 H), 2.24-2.36 (m, 1 H), 1.18-1.29 (m, 4 H) 444.2 [M+H]+ 98.9%
943 (CD 3OD) δ 8.62-8.72 (m, 1 H), 7.57-7.73 (m, 2 H), 6.85-7.03 (m, 2 H), 6.67-6.81 (m, 1 H), 4.89-5.05 (m, 1 H), 3.34-3.76 (m, 1 H), 2.91-3.18 (m, 1 H), 2.76-2.86 (m, 1 H), 2.25-2.36 (m, 1 H), 1.19-1.29 (m, 4 H) 444.2 [M+H]+ 94.9%
944 (CD 3OD) δ 8.64-8.72 (m, 1 H), 7.76-7.81 (m, 1 H), 7.58-7.66 (m, 1 H), 6.88-7.07 (m, 2 H), 6.73-6.82 (m, 1 H), 4.90-5.04 (m, 1 H), 3.35-3.78 (m, 1 H), 2.95-3.19 (m, 1 H), 2.79-2.87 (m, 1 H), 2.63 (s, 3 H) 418.2 [M+H]+ 100%
945 (CD 3OD) δ 8.63-8.72 (m, 1 H), 7.77-7.86 (m, 1 H), 7.58-7.66 (m, 1 H), 6.89-7.04 (m, 2 H), 6.73-6.83 (m, 1 H), 4.90-5.06 (m, 1 H), 3.35-3.77 (m, 1 H), 2.94-3.19 (m, 1 H), 2.78-2.88 (m, 1 H), 2.63 (s, 3 H) 418.2 [M+H]+ 92.1%
946 (CD 3OD) δ 8.26-8.38 (m, 1 H), 7.68 (s, 1 H), 7.45 (s, 0.3 H), 6.87-7.01 (m, 1.7 H), 6.78-6.87 (m, 1 H), 6.65-6.75 (m, 1 H), 4.99 (dd, 1 H), 3.72 (ddd, 0.7 H), 3.35-3.42 (m, 0.3 H), 2.74-3.20 (m, 2 H), 2.26-2.38 (m, 1 H), 1.18-1.30 (m, 4 H) 394.2 [M+H] + 99.3%
947 (CD 3OD) δ 8.27-8.38 (m, 1 H), 7.69 (s, 1 H), 7.45 (s, 0.3 H), 6.87-7.02 (m, 1.7 H), 6.78-6.87 (m, 1 H), 6.63-6.77 (m, 1 H), 4.99 (dd, 1 H), 3.63-3.80 (m, 0.7 H), 3.37-3.44 (m, 0.3 H), 2.77-3.17 (m, 2 H), 2.24-2.40 (m, 1 H), 1.20-1.32 (m, 4 H) 394.2 [M+H] + 98.3%
948 (CD 3OD) δ 8.62-8.72 (m, 1 H), 7.69 (s, 1 H), 7.58-7.65 (m, 1 H), 6.93-7.44 (m, 2 H), 6.71-6.80 (m, 1 H), 4.90-5.03 (m, 1 H), 3.35-3.76 (m, 1 H), 2.80-3.15 (m, 2 H), 1.45-1.49 (m, 9 H) 460.2 [M+H] + 99.3%
949 (CD 3OD) δ 8.63-8.71 (m, 1 H), 7.69 (s, 1 H), 7.59-7.65 (m, 1 H), 6.94-7.44 (m, 2 H), 6.72-6.81 (m, 1 H), 4.90-5.03 (m, 1 H), 3.35-3.76 (m, 1 H), 2.80-3.17 (m, 2 H), 1.45-1.49 (m, 9 H) 460.2 [M+H]+ 98.2%
950 (CD 3OD) δ 8.70 (d, 1 H), 7.56-7.76 (m, 2 H), 7.41 (br s, 0.4 H), 6.92-7.03 (m, 1.6 H), 6.69-6.83 (m, 1 H), 4.98 (br dd, 1 H), 3.69-3.79 (m, 0.6 H), 3.35 (s, 0.4 H), 2.81-3.20 (m, 2 H), 1.75-2.02 (m, 6 H) 464.2 [M+H] + 97.2%
951 (CD 3OD) δ 8.69 (d, 1 H), 7.57-7.76 (m, 2 H), 7.41 (s, 0.4 H), 6.92-7.03 (m, 1.6 H), 6.71-6.81 (m, 1 H), 4.98 (br dd, 1 H), 3.69-3.79 (m, 0.6 H), 3.34-3.41 (m, 0.4 H), 2.79-3.21 (m, 2 H), 1.79-1.98 (m, 6 H) 464.2 [M+H] + 94.7%
952 (CD 3OD) δ 8.40 (s, 1 H), 8.10 (d, 1 H), 7.79-7.91 (m, 1 H), 7.66-7.75 (m, 1 H), 7.54-7.63 (m, 0.5 H), 7.24-7.38 (m, 2 H), 6.86 (s, 1 H), 6.66 (s, 0.5 H), 5.08-5.14 (m, 0.5 H), 4.94 (br s, 1 H), 4.02 (d, 3 H), 3.79-3.98 (m, 0.5 H), 2.99 (s, 1 H), 2.82-2.91 (m, 1 H) 484.2 [M+H] + 100%
953 (CD 3OD) δ 8.39 (s, 1 H), 8.09 (d, 1 H), 7.78-7.89 (m, 1 H), 7.65-7.74 (m, 1 H), 7.54-7.61 (m, 0.5 H), 7.32 (br d, 2 H), 6.85 (s, 1 H), 6.65 (s, 0.5 H), 5.10 (br dd, 0.5 H), 4.93-5.01 (m, 1 H), 4.00 (d, 3 H), 3.95 (br dd, 0.5 H), 2.94-3.18 (m, 1 H), 2.85 (br d, 1 H) 484.2 [M+H] + 99.2%
954 (CD 3OD) δ 8.23-8.40 (m, 1 H), 7.96-8.04 (m, 1 H), 7.53-7.76 (m, 1.3 H), 6.91-7.06 (m, 1.7 H), 6.65-6.89 (m, 2 H), 5.03-5.26 (m, 1 H), 3.69-3.93 (m, 3.7 H), 3.36-3.48 (m, 0.3 H), 2.92-3.25 (m, 1 H), 2.79-2.90 (m, 1 H), 2.57-2.75 (m, 3 H) 448.2 [M+H] + 98.7%
955 (CD 3OD) δ 8.24-8.40 (m, 1 H), 7.90-8.04 (m, 1 H), 7.51-7.74 (m, 1.4 H), 6.89-7.01 (m, 1.6 H), 6.64-6.88 (m, 2 H), 5.05-5.22 (m, 1 H), 3.67-3.91 (m, 3.5 H), 3.35-3.48 (m, 0.5 H), 2.91-3.24 (m, 1 H), 2.74-2.90 (m, 1 H), 2.58-2.72 (m, 3 H) 448.2 [M+H] + 96.7%
956 (CD 3OD) δ 9.40-9.53 (m, 1 H), 8.82-8.91 (m, 2 H), 8.22-8.37 (m, 1 H), 7.73 (s, 1 H), 7.52 (s, 0.3 H), 6.97-7.03 (m, 1.7 H), 6.73-6.88 (m, 1 H), 6.59-6.68 (m, 1 H), 5.02 (br dd, 0.5 H), 3.77-3.89 (m, 0.5 H), 3.46 (td, 0.5 H), 2.97-3.28 (m, 1.5 H), 2.80-2.93 (m, 1 H), 2.43-2.49 (m, 3 H) 428.2 [M+H] + 99.7%
957 (CD 3OD) δ 9.34-9.52 (m, 1 H), 8.84 (br d, 2 H), 8.19-8.36 (m, 1 H), 7.70 (s, 1 H), 7.50 (s, 0.3 H), 6.96-7.01 (m, 1.7 H), 6.74-6.83 (m, 1 H), 6.59-6.66 (m, 1 H), 5.00 (br dd, 0.5 H), 3.75-3.87 (m, 0.5 H), 3.45 (td, 0.5 H), 2.95-3.27 (m, 1.5 H), 2.80-2.90 (m, 1 H), 2.42-2.46 (m, 3 H) 428.2 [M+H] + 99.3%
958 (CD 3OD) δ 8.42 (s, 1 H), 7.72 (s, 1 H), 7.60 (br d, 1 H), 7.12-7.31 (m, 2 H), 7.01-7.05 (m, 1 H), 6.56-6.93 (m, 2 H), 4.24-4.43 (m, 1 H), 3.77-3.95 (m, 1 H), 2.78-3.08 (m, 2 H) 419.1 [M+H] + 99.6%
959 (CD 3OD) δ 8.44 (s, 1 H), 7.71 (s, 1 H), 7.62 (br d, 1 H), 7.15-7.31 (m, 2 H), 7.03-7.06 (m, 1 H), 6.51-6.95 (m, 2 H), 4.25-4.43 (m, 1 H), 3.73-3.98 (m, 1 H), 2.80-3.11 (m, 2 H) 419.1 [M+H] + 99.9%
960 (CD 3OD) δ 7.67 (s, 1 H), 7.61 (br d, 1 H), 6.98-7.28 (m, 3 H), 6.78 (br s, 2 H), 4.26-4.48 (m, 1 H), 3.75-4.00 (m, 0.5 H), 3.35-3.52 (m, 0.5 H), 2.77-3.16 (m, 2 H), 1.57-1.70 (m, 6 H) 477.1 [M+H] + 100%
961 (CD 3OD) δ 7.67 (s, 1 H), 7.60 (br d, 1 H), 6.99-7.28 (m, 3 H), 6.62-6.90 (m, 2 H), 4.27-4.41 (m, 1 H), 3.80-3.97 (m, 0.5 H), 3.37-3.51 (m, 0.5 H), 2.77-3.16 (m, 2 H), 1.58-1.69 (m, 6 H) 477.1 [M+H] + 98.3%
962 (CD 3OD) δ 9.38-9.55 (m, 1 H), 8.81-8.95 (m, 2 H), 8.28-8.38 (m, 1 H), 7.70 (s, 1 H), 6.70-7.05 (m, 4 H), 5.03 (br dd, 0.5 H), 3.75-3.85 (m, 0.5 H), 3.43 (td, 0.5 H), 2.94-3.28 (m, 1.5 H), 2.80-2.91 (m, 1 H) 432.1 [M+H] + 100%
963 (CD 3OD) δ 9.45-9.52 (m, 1 H), 8.78-8.90 (m, 2 H), 8.26-8.44 (m, 1 H), 7.71 (s, 1 H), 6.74-7.08 (m, 4 H), 5.03 (br dd, 0.5 H), 3.72-3.88 (m, 0.5 H), 3.38-3.51 (m, 0.5 H), 2.98-3.26 (m, 1.5 H), 2.86 (br d, 1 H) 432.1 [M+H] + 99.7%
964 (CD 3OD) δ 8.35 (dd, 1 H), 7.62-7.84 (m, 2.5 H), 7.50-7.58 (m, 1 H), 7.14-7.25 (m, 2 H), 6.98-7.07 (m, 1.5 H), 6.60-6.84 (m, 1 H), 5.07 (br dd, 1 H), 3.89-3.97 (m, 0.5 H), 3.37-3.44 (m, 0.5 H), 2.85-3.24 (m, 2 H) 486.1 [M+H] + 99.7%
965 (CD 3OD) δ 8.30-8.38 (m, 1 H), 7.59-7.87 (m, 2.5 H), 7.49-7.58 (m, 1 H), 7.12-7.25 (m, 2 H), 6.97-7.07 (m, 1.5 H), 6.61-6.84 (m, 1 H), 5.07 (br dd, 1 H), 3.87-4.00 (m, 0.6 H), 3.38-3.44 (m, 0.4 H), 2.84-3.25 (m, 2 H) 486.1 [M+H] + 99.5%
966 (CDCl 3) δ 8.06-8.22 (m, 1 H), 7.53-7.63 (m, 1 H), 7.43 (s, 0.3 H), 7.30-7.38 (m, 1 H), 6.95 (s, 0.7 H), 6.93 (br d, 1 H), 6.50 (s, 1 H), 5.17 (br dd, 0.7 H), 4.94 (br dd, 0.3 H), 3.76-3.85 (m, 0.7 H), 3.44-3.51 (m, 0.3 H), 3.10-3.20 (m, 0.7 H), 2.94-3.05 (m, 0.5 H), 2.81 (br d, 0.5 H), 2.73 (br d, 0.3 H), 2.22-2.29 (m, 4 H), 1.19-1.28 (m, 4 H) 390.2 [M+H] + 100%
967 (CDCl 3) δ 8.08-8.21 (m, 1 H), 7.57-7.62 (m, 1 H), 7.45 (s, 0.3 H), 7.31-7.38 (m, 1 H), 6.96 (s, 0.7 H), 6.93 (br d, 1 H), 6.51 (s, 1 H), 5.18 (dd, 0.7 H), 4.96 (dd, 0.3 H), 3.76-3.87 (m, 0.7 H), 3.45-3.54 (m, 0.3 H), 3.11-3.21 (m, 0.7 H), 2.93-3.06 (m, 0.5 H), 2.82 (br d, 0.5 H), 2.74 (br d, 0.3 H), 2.26-2.31 (m, 4 H), 1.21-1.28 (m, 4 H) 390.2 [M+H] + 100%
968 (CD 3OD) δ 7.71 (d, 1 H), 7.56-7.65 (m, 1 H), 7.46 (s, 0.4 H), 7.14-7.23 (m, 1 H), 7.02-7.08 (m, 1 H), 6.97 (s, 0.6 H), 6.60-6.83 (m, 1 H), 4.95-5.03 (m, 1 H), 3.83-3.96 (m, 0.6 H), 3.36-3.43 (m, 0.4 H), 2.82-3.18 (m, 2 H), 1.87-1.94 (m, 6 H) 430.2 [M+H] + 99.6%
969 (CD 3OD) δ 7.59 (d, 1 H), 7.43-7.52 (m, 1 H), 7.33 (s, 0.4 H), 7.02-7.10 (m, 1 H), 6.92 (d, 1 H), 6.85 (s, 0.6 H), 6.50-6.69 (m, 1 H), 4.85-4.90 (m, 1 H), 3.72-3.82 (m, 0.6 H), 3.24-3.31 (m, 0.4 H), 2.71-3.05 (m, 2 H), 1.74-1.82 (m, 6 H) 430.1 [M+H] + 99.5%
970 (CD 3OD) δ 7.99-8.14 (m, 1 H), 7.70 (s, 1 H), 6.89-7.47 (m, 1 H), 6.77-6.83 (m, 1 H), 6.52-6.72 (m, 2 H), 4.97 (br d, 1 H), 3.89-4.02 (m, 3 H), 3.37-3.82 (m, 1 H), 2.75-3.23 (m, 2 H), 1.82-2.00 (m, 6 H) 426.2 [M+H] + 98.8%
971 (CD 3OD) δ 7.87-8.04 (m, 1 H), 7.59 (s, 1 H), 6.78-7.37 (m, 1 H), 6.68 (q, 1 H), 6.38-6.58 (m, 2 H), 4.85 (br d, 1 H), 3.79-3.90 (m, 3 H), 3.25-3.71 (m, 1 H), 2.65-3.12 (m, 2 H), 1.72-1.84 (m, 6 H) 426.1 [M+H] + 98.4%
972 (CD 3OD) δ 8.40-8.50 (m, 1 H), 7.99-8.03 (m, 1 H), 7.71 (s, 1 H), 7.53-7.66 (m, 1.3 H), 7.16-7.26 (m, 1 H), 6.97 (s, 0.7 H), 6.83-6.92 (m, 1 H), 6.57-6.67 (m, 1 H), 4.99-5.12 (m, 1 H), 3.90 (s, 3 H), 3.73-3.84 (m, 0.7 H), 3.42 (td, 0.3 H), 2.96-3.26 (m, 1 H), 2.80-2.91 (m, 1 H), 2.66-2.72 (m, 3 H) 430.2 [M+H] + 100%
973 (CD 3OD) δ 8.39-8.50 (m, 1 H), 8.00-8.03 (m, 1 H), 7.71 (br s, 1 H), 7.56-7.65 (m, 1.3 H), 7.17-7.25 (m, 1 H), 6.97 (s, 0.7 H), 6.83-6.92 (m, 1 H), 6.57-6.68 (m, 1 H), 5.09 (br dd, 1 H), 3.91 (s, 3 H), 3.72-3.84 (m, 0.7 H), 3.42 (td, 0.3 H), 2.96-3.26 (m, 1 H), 2.86 (br d, 1 H), 2.66-2.72 (m, 3 H) 430.2 [M+H] + 98.6%
974 (CD 3OD) δ 8.79 (d, 1 H), 8.28-8.41 (m, 1 H), 8.10 (td, 1 H), 7.63-7.79 (m, 2 H), 7.42-7.60 (m, 1.5 H), 7.18-7.34 (m, 1 H), 7.00 (s, 0.5 H), 6.71-6.87 (m, 1 H), 6.54-6.70 (m, 1 H), 5.06 (br dd, 1 H), 3.79-3.93 (m, 0.6 H), 3.46 (td, 0.4 H), 2.98-3.29 (m, 1 H), 2.82-2.95 (m, 1 H) 431.1 [M+H] + 99.7%
975 (CD 3OD) δ 8.79 (d, 1 H), 8.29-8.42 (m, 1 H), 8.11 (td, 1 H), 7.64-7.77 (m, 2 H), 7.40-7.59 (m, 1.4 H), 7.17-7.34 (m, 1 H), 7.00 (s, 0.6 H), 6.71-6.89 (m, 1 H), 6.59-6.70 (m, 1 H), 5.06 (br dd, 1 H), 3.80-3.96 (m, 0.5 H), 3.41-3.53 (m, 0.5 H), 2.95-3.28 (m, 1 H), 2.88 (dd, 1 H) 431.2 [M+H] + 97.2%
976 (CD 3OD) δ 7.80 (dd, 1 H), 7.69 (d, 1 H), 7.49-7.62 (m, 1.5 H), 7.16 (dd, 1 H), 6.95-7.03 (m, 2.5 H), 6.60-6.78 (m, 1 H), 5.05 (br dd, 1 H), 4.02 (d, 3 H), 3.90 (ddd, 0.6 H), 3.33-3.41 (m, 0.4 H), 2.82-3.20 (m, 2 H) 450.1 [M+H] + 100%
977 (CD 3OD) δ 7.80 (dd, 1 H), 7.70 (br d, 1 H), 7.50-7.63 (m, 1.5 H), 7.10-7.21 (m, 1 H), 6.94-7.04 (m, 2.5 H), 6.60-6.80 (m, 1 H), 5.05 (br dd, 1 H), 4.02 (d, 3 H), 3.84-3.95 (m, 0.6 H), 3.34-3.41 (m, 0.4 H), 2.82-3.21 (m, 2 H) 450.1 [M+H] + 100%
978 (CD 3OD) δ 9.28-9.45 (m, 1 H), 8.64-8.86 (m, 2 H), 7.62 (br s, 1 H), 7.18-7.58 (m, 2 H), 6.82-7.18 (m, 2 H), 6.48-6.81 (m, 1 H), 4.82-5.00 (m, 1 H), 3.25-3.91 (m, 1 H), 2.72-3.16 (m, 2 H) 448.1 [M+H] + 98.7%
979 (CD 3OD) δ 9.42-9.54 (m, 1 H), 8.76-8.91 (m, 2 H), 7.74 (br d, 1 H), 7.43-7.70 (m, 2 H), 6.98-7.23 (m, 2 H), 6.62-6.86 (m, 1 H), 4.94-5.11 (m, 1 H), 3.38-4.01 (m, 1 H), 2.84-3.28 (m, 2 H) 448.1 [M+H] + 96.9%
980 (CD 3OD) δ 8.48-8.64 (m, 1 H), 7.69 (s, 1 H), 7.39-7.50 (m, 1.2 H), 7.08-7.13 (m, 0.4 H), 6.61-7.00 (m, 3.4 H), 5.00 (br dd, 1 H), 3.64-3.77 (m, 0.5 H), 3.39 (br d, 0.5 H), 2.77-3.18 (m, 2 H), 2.27-2.35 (m, 1 H), 1.19-1.31 (m, 4 H) 426.2 [M+H] + 100%
981 (CD 3OD) δ 8.52-8.61 (m, 1 H), 7.69 (s, 1 H), 7.38-7.49 (m, 1.2 H), 7.07-7.15 (m, 0.4 H), 6.68-7.00 (m, 3.4 H), 5.00 (br dd, 1 H), 3.66-3.78 (m, 0.5 H), 3.34-3.40 (m, 0.5 H), 2.78-3.19 (m, 2 H), 2.25-2.36 (m, 1 H), 1.20-1.30 (m, 4 H) 426.2 [M+H] + 100%
982 (CD 3OD) δ 8.62-8.69 (m, 1 H), 7.91-8.01 (m, 1 H), 7.68-7.80 (m, 2 H), 7.55-7.66 (m, 1 H), 7.48 (s, 0.4 H), 7.13-7.24 (m, 1 H), 6.97-7.08 (m, 1.6 H), 6.64-6.84 (m, 1 H), 4.98-5.10 (m, 1 H), 3.87-4.00 (m, 0.6 H), 3.38-3.48 (m, 0.4 H), 2.85-3.26 (m, 2 H) 465.1 [M+H] + 98.6%
983 (CD 3OD) δ 8.64 (d, 1 H), 7.94 (br t, 1 H), 7.68-7.79 (m, 2 H), 7.55-7.65 (m, 1 H), 7.47 (s, 0.4 H), 7.17 (dt, 1 H), 6.95-7.07 (m, 1.6 H), 6.61-6.84 (m, 1 H), 4.98-5.04 (m, 1 H), 3.93 (br s, 0.6 H), 3.36-3.46 (m, 0.4 H), 2.84-3.22 (m, 2 H) 465.1 [M+H] + 96.2%
984 (CD 3OD) δ 8.83-9.06 (m, 1 H), 8.37 (s, 1 H), 7.42-7.87 (m, 3.5 H), 7.19-7.33 (m, 1 H), 6.98 (s, 0.5 H), 6.80 (d, 0.5 H), 6.59-6.73 (m, 1.5 H), 5.12 (br dd, 1 H), 3.75-3.91 (m, 0.6 H), 3.39-3.48 (m, 0.4 H), 3.13-3.26 (m, 0.7 H), 3.02 (br t, 0.3 H), 2.87 (br d, 1 H) 470.2 [M+H] + 98.6%
985 (CD 3OD) δ 8.84-9.10 (m, 1 H), 8.37 (s, 1 H), 7.42-7.88 (m, 3.5 H), 7.19-7.34 (m, 1 H), 6.98 (s, 0.5 H), 6.80 (d, 0.5 H), 6.57-6.74 (m, 1.5 H), 5.12 (br dd, 1 H), 3.79-3.91 (m, 0.7 H), 3.40-3.49 (m, 0.3 H), 3.12-3.24 (m, 1 H), 2.87 (br d, 1 H) 470.2 [M+H] + 95.7%
986 (CD 3OD) δ 7.65-7.95 (m, 1 H), 7.21-7.52 (m, 2 H), 6.53-7.08 (m, 3 H), 4.99 (br d, 1 H), 3.38-3.88 (m, 1 H), 2.79-3.25 (m, 2 H), 1.79-2.01 (m, 6 H) 414.2 [M+H] + 99.4%
987 (CD 3OD) δ 7.63-8.07 (m, 1 H), 7.20-7.53 (m, 2 H), 6.53-7.16 (m, 3 H), 4.97-5.02 (m, 1 H), 3.36-3.86 (m, 1 H), 2.80-3.25 (m, 2 H), 1.82-1.99 (m, 6 H) 414.2 [M+H] + 95.1%
988 (CD 3OD) δ 8.19-8.35 (m, 1 H), 7.95-8.06 (m, 1 H), 7.52-7.74 (m, 1.4 H), 6.95-7.06 (m, 1.6 H), 6.55-6.86 (m, 2 H), 5.09 (br dd, 1 H), 3.70-3.99 (m, 3.7 H), 3.36-3.50 (m, 0.4 H), 2.94-3.28 (m, 1 H), 2.79-2.91 (m, 1 H), 2.60-2.74 (m, 3 H), 2.34-2.54 (m, 3 H) 444.2 [M+H] + 97.4%
989 (CD 3OD) δ 8.18-8.34 (m, 1 H), 7.93-8.04 (m, 1 H), 7.48-7.76 (m, 1.4 H), 6.95-7.06 (m, 1.6 H), 6.51-6.85 (m, 2 H), 5.07 (br dd, 1 H), 3.66-3.93 (m, 3.7 H), 3.35-3.48 (m, 0.3 H), 2.94-3.23 (m, 1 H), 2.78-2.92 (m, 1 H), 2.58-2.71 (m, 3 H), 2.31-2.51 (m, 3 H) 444.2 [M+H] + 97.7%
990 (CD 3OD) δ 8.46 (d, 1 H), 7.50-7.75 (m, 2 H), 7.18-7.24 (m, 1 H), 6.87 (td, 1.6 H), 6.33-6.72 (m, 1.4 H), 4.79 (br s, 0.4 H), 4.21 (br d, 0.6 H), 3.79 (br t, 0.6 H), 3.37-3.52 (m, 0.4 H), 2.91-3.21 (m, 1 H), 2.83 (br d, 1 H), 1.51-1.69 (m, 6 H) 427.2 [M+H] + 100%
991 (CD 3OD) δ 8.46 (d, 1 H), 7.54-7.76 (m, 2 H), 7.20 (t, 1 H), 6.86 (td, 1.6 H), 6.32-6.69 (m, 1.4 H), 4.80 (br s, 0.3 H), 4.21 (br d, 0.7 H), 3.79 (br t, 0.7 H), 3.41 (br s, 0.3 H), 2.92-3.22 (m, 1 H), 2.83 (br d, 1 H), 1.55-1.70 (m, 6 H) 427.3 [M+H] + 95.9%
992 (CD 3OD) δ 8.45 (br d, 1 H), 7.50-7.75 (m, 2 H), 7.10-7.28 (m, 1 H), 6.85 (br t, 1.5 H), 6.34-6.71 (m, 1.5 H), 4.27 (br d, 1 H), 3.34-3.91 (m, 1 H), 2.70-3.21 (m, 2 H), 2.37 (s, 3 H), 1.57-2.02 (m, 6 H) 416.2 [M+H] + 100%
993 (CD 3OD) δ 8.44 (br d, 1 H), 7.49-7.75 (m, 2 H), 7.18 (dd, 1 H), 6.36-6.92 (m, 3 H), 4.04-4.43 (m, 1 H), 3.35-3.84 (m, 1 H), 2.64-3.22 (m, 2 H), 2.37 (s, 3 H), 1.64-2.06 (m, 6 H) 416.3 [M+H] + 99.6%
994 (CD 3OD) δ 8.46 (dd, 1 H), 7.69 (s, 1 H), 7.61 (br d, 1 H), 7.11-7.30 (m, 2 H), 6.80-7.05 (m, 2 H), 6.63 (s, 1 H), 4.39 (br d, 1 H), 3.73 (br s, 1 H), 2.74-3.27 (m, 2 H), 1.26-1.58 (m, 4 H) 441.2 [M+H] + 99.3%
995 (CD 3OD) δ 8.34 (dd, 1 H), 7.57 (s, 1 H), 7.49 (br d, 1 H), 7.00-7.20 (m, 2 H), 6.68-6.92 (m, 2 H), 6.51 (s, 1 H), 4.13-4.37 (m, 1 H), 3.51-3.77 (m, 1 H), 2.65-3.12 (m, 2 H), 1.14-1.49 (m, 4 H) 441.2 [M+H] + 99.3%
996 (CD 3OD) δ 8.42 (d, 1 H), 7.50-7.69 (m, 2 H), 7.17 (t, 1 H), 6.77-6.88 (m, 1.6 H), 6.29-6.64 (m, 1.4 H), 4.97-5.14 (m, 1 H), 4.75 (br d, 0.4 H), 4.12 (br d, 0.6 H), 3.74 (br t, 0.6 H), 3.38 (br s, 0.4 H), 2.90-3.13 (m, 1 H), 2.78 (br dd, 1 H), 1.55 (br d, 3 H) 459.2 [M+H] + 94.9%
997 (CD 3OD) δ 8.46 (d, 1 H), 7.57-7.80 (m, 2 H), 7.21 (t, 1 H), 6.82-6.91 (m, 1.7 H), 6.38-6.67 (m, 1.3 H), 4.97-5.11 (m, 1 H), 4.74-4.83 (m, 0.4 H), 4.18 (br d, 0.6 H), 3.78 (br t, 0.6 H), 3.42 (br s, 0.4 H), 2.92-3.20 (m, 1 H), 2.83 (br dd, 1 H), 1.59 (br d, 3 H) 459.1 [M+H] + 97.0%
998 (CD 3OD) δ 8.42 (d, 1 H), 7.51-7.70 (m, 2 H), 7.12-7.23 (m, 1 H), 6.79-6.89 (m, 1.6 H), 6.25-6.64 (m, 1.4 H), 4.94-5.11 (m, 1 H), 4.77 (br s, 0.4 H), 4.12 (br d, 0.6 H), 3.69-3.82 (m, 0.6 H), 3.38 (br s, 0.4 H), 2.89-3.16 (m, 1 H), 2.78 (br dd, 1 H), 1.55 (br d, 3 H) 459.2 [M+H] + 93.1%
999 (CD 3OD) δ 8.46 (d, 1 H), 7.54-7.74 (m, 2 H), 7.21 (br t, 1 H), 6.87 (t, 1.7 H), 6.35-6.69 (m, 1.3 H), 4.97-5.05 (m, 1 H), 4.74-4.84 (m, 0.4 H), 4.16 (br d, 0.6 H), 3.74-3.93 (m, 0.6 H), 3.42 (br s, 0.4 H), 2.93-3.19 (m, 1 H), 2.82 (br dd, 1 H), 1.59 (br d, 3 H) 459.2 [M+H] + 98.8%
1000 (CD 3OD) δ 8.34 (d, 1 H), 7.67 (s, 1 H), 6.96 (dd, 1 H), 6.47-6.87 (m, 3 H), 4.26-4.81 (m, 1 H), 3.35-3.78 (m, 1 H), 2.90-3.22 (m, 1 H), 2.80 (br d, 1 H), 2.37 (s, 3 H), 1.49-1.67 (m, 6 H) 425.0 [M+H] + 98.6%
1001 (CD 3OD) δ 8.34 (d, 1 H), 7.67 (s, 1 H), 6.96 (dd, 1 H), 6.45-6.87 (m, 3 H), 4.27-4.84 (m, 1 H), 3.35-3.79 (m, 1 H), 2.66-3.22 (m, 2 H), 2.37 (s, 3 H), 1.49-1.70 (m, 6 H) 425.1 [M+H] + 99.8%
1002 (CD 3OD) δ 8.69 (d, 1 H), 8.42 (s, 1 H), 7.70 (s, 1 H), 7.63 (d, 1 H), 7.10-7.31 (m, 1 H), 6.55-7.02 (m, 3 H), 4.33 (br s, 1 H), 3.73 (br s, 1 H), 2.73-3.14 (m, 2 H) 453.1 [M+H] + 99.7%
1003 (CD 3OD) δ 8.69 (d, 1 H), 8.42 (s, 1 H), 7.69 (s, 1 H), 7.63 (d, 1 H), 7.11-7.29 (m, 1 H), 6.56-7.02 (m, 3 H), 4.35 (br d, 1 H), 3.73 (br s, 1 H), 2.74-3.15 (m, 2 H) 453.1 [M+H] + 99.2%
1004 (CD 3OD) δ 8.44 (s, 1 H), 8.33 (d, 1 H), 7.72 (s, 1 H), 7.01-7.41 (m, 2 H), 6.61-6.92 (m, 2 H), 6.40-6.57 (m, 1 H), 4.26-4.84 (m, 1 H), 3.48-3.82 (m, 1 H), 3.08 (br s, 1 H), 2.81 (br d, 1 H), 2.38 (s, 3 H) 399.2 [M+H] + 99.7%
1005 (CD 3OD) δ 8.44 (s, 1 H), 8.33 (d, 1 H), 7.69 (s, 1 H), 7.00-7.41 (m, 2 H), 6.61-6.92 (m, 2 H), 6.49 (br s, 1 H), 4.24-4.79 (m, 1 H), 3.41-3.83 (m, 1 H), 2.96-3.16 (m, 1 H), 2.81 (br d, 1 H), 2.38 (s, 3 H) 399.2 [M+H] + 98.5%
1006 (CD 3OD) δ 8.74 (d, 1 H), 8.19-8.40 (m, 2 H), 8.06 (br s, 1 H), 7.59-7.78 (m, 2 H), 6.73-7.40 (m, 5 H), 4.80-4.86 (m, 0.4 H), 4.54 (br d, 0.6 H), 3.51-3.87 (m, 1 H), 2.99-3.32 (m, 1 H), 2.87 (br d, 1 H) 480.2 [M+H] + 100%
1007 (CD 3OD) δ 8.74 (d, 1 H), 8.16-8.50 (m, 2 H), 8.05 (br d, 1 H), 7.54-7.78 (m, 2 H), 6.64-7.47 (m, 5 H), 4.78-4.87 (m, 0.4 H), 4.54 (br d, 0.6 H), 3.53-3.90 (m, 1 H), 2.96-3.30 (m, 1 H), 2.87 (br d, 1 H) 480.2 [M+H] + 99.3%
1008 (CD 3OD) δ 7.87-8.40 (m, 3 H), 7.77 (br s, 1 H), 7.05-7.37 (m, 1 H), 6.94-7.04 (m, 1 H), 6.53-6.92 (m, 3 H), 4.50 (br s, 1 H), 3.98 (br s, 3 H), 3.77 (br s, 0.6 H), 3.49 (br s, 0.4 H), 2.71-3.26 (m, 2 H), 2.45 (s, 3 H) 479.2 [M+H] + 95.3%
1009 (CD 3OD) δ 7.85-8.39 (m, 3 H), 7.71 (s, 1 H), 7.04-7.35 (m, 1 H), 6.99 (d, 1 H), 6.48-6.92 (m, 3 H), 4.32-4.72 (m, 1 H), 3.97 (br s, 3 H), 3.68-3.85 (m, 0.6 H), 3.46 (br d, 0.4 H), 2.73-3.23 (m, 2 H), 2.44 (s, 3 H) 479.2 [M+H] + 92.8%
1010 (CD 3OD) δ 8.23-8.33 (m, 1 H), 7.43-7.71 (m, 1.3 H), 6.90-7.01 (m, 1.7 H), 6.72-6.81 (m, 1 H), 6.51-6.63 (m, 1 H), 4.90-4.97 (m, 1 H), 3.74 (ddd, 0.7 H), 3.38 (td, 0.3 H), 3.07-3.18 (m, 0.6 H), 2.90-3.02 (m, 0.4 H), 2.81 (br dd, 1 H), 2.60-2.65 (m, 3 H), 2.39-2.47 (m, 3 H) 364.2 [M+H] + 100%
1011 (CD 3OD) δ 8.23-8.35 (m, 1 H), 7.72-7.83 (m, 1 H), 7.49 (s, 0.3 H), 6.92-7.01 (m, 1.7 H), 6.71-6.83 (m, 1 H), 6.49-6.65 (m, 1 H), 4.92-4.99 (m, 1 H), 3.74 (ddd, 0.7 H), 3.38 (td, 0.3 H), 3.07-3.19 (m, 0.7 H), 2.92-3.02 (m, 0.3 H), 2.77-2.87 (m, 1 H), 2.59-2.67 (m, 3 H), 2.38-2.48 (m, 3 H) 364.2 [M+H] + 100%
1012 (CD 3OD) δ 8.31 (d, 1 H), 7.69 (s, 1.3 H), 6.89-7.07 (m, 1.7 H), 6.74-6.86 (m, 1 H), 6.54-6.66 (m, 1 H), 5.21 (dd, 0.7 H), 4.92-5.04 (m, 1 H), 3.53-3.88 (m, 5 H), 3.39 (br dd, 0.3 H), 2.75-3.22 (m, 2 H), 2.40-2.49 (m, 3 H), 1.86-2.17 (m, 4 H) 451.3 [M+H] + 100%
1013 (CD 3OD) δ 8.22-8.38 (m, 1 H), 7.57-7.80 (m, 1.3 H), 6.74-7.11 (m, 2.7 H), 6.56-6.70 (m, 1 H), 5.21 (dd, 0.7 H), 4.97 (br s, 1 H), 3.62-3.80 (m, 5 H), 3.37-3.45 (m, 0.3 H), 2.75-3.19 (m, 2 H), 2.41-2.51 (m, 3 H), 1.89-2.15 (m, 4 H) 451.3 [M+H] + 100%
1014 (CD 3OD) δ 8.35 (d, 1 H), 7.54-7.82 (m, 1.4 H), 6.81-7.12 (m, 2.6 H), 6.75 (s, 1 H), 5.23 (dd, 0.6 H), 4.97 (br d, 1 H), 3.61-3.82 (m, 5 H), 3.35-3.47 (m, 0.6 H), 2.74-3.22 (m, 2 H), 1.76-2.24 (m, 4 H) 455.2 [M+H] + 100%
1015 (CD 3OD) δ 8.23 (d, 1 H), 7.41-7.74 (m, 1.3 H), 6.68-6.91 (m, 2.7 H), 6.63 (s, 1 H), 5.11 (br dd, 1 H), 4.85 (br s, 1 H), 3.52-3.68 (m, 5 H), 3.24-3.30 (m, 0.6 H), 2.61-3.09 (m, 2 H), 1.74-2.01 (m, 4 H) 455.2 [M+H] + 99.0%
1016 (CD 3OD) δ 8.20-8.33 (m, 1 H), 7.51-7.73 (m, 2.3 H), 7.03-7.09 (m, 1 H), 6.93-7.01 (m, 1.7 H), 6.71-6.83 (m, 1 H), 6.54-6.67 (m, 1 H), 5.04 (dd, 1 H), 4.26-4.36 (m, 3 H), 3.79 (ddd, 0.7 H), 3.35-3.52 (m, 0.3 H), 2.76-3.25 (m, 2 H), 2.36-2.51 (m, 3 H) 430.2 [M+H] + 99.5%
1017 (CD 3OD) δ 8.20-8.33 (m, 1 H), 7.48-7.75 (m, 2.3 H), 7.04-7.11 (m, 1 H), 6.91-7.03 (m, 1.7 H), 6.71-6.83 (m, 1 H), 6.53-6.67 (m, 1 H), 4.98-5.12 (m, 1 H), 4.24-4.37 (m, 3 H), 3.71-3.86 (m, 0.7 H), 3.36-3.52 (m, 0.3 H), 2.73-3.26 (m, 2 H), 2.37-2.49 (m, 3 H) 430.2 [M+H] + 99.4%
1018 (CD 3OD) δ 8.26-8.37 (m, 1 H), 7.49-7.73 (m, 2.3 H), 7.05-7.11 (m, 1 H), 6.90-7.02 (m, 1.7 H), 6.78-6.87 (m, 1 H), 6.72-6.78 (m, 1 H), 5.07 (dd, 1 H), 4.28-4.33 (m, 3 H), 3.78 (ddd, 0.7 H), 3.41 (td, 0.3 H), 2.75-3.26 (m, 2 H) 434.2 [M+H] + 99.3%
1019 (CD 3OD) δ 8.25-8.38 (m, 1 H), 7.51-7.73 (m, 2.3 H), 7.05-7.11 (m, 1 H), 6.91-7.02 (m, 1.7 H), 6.78-6.87 (m, 1 H), 6.72-6.78 (m, 1 H), 5.07 (dd, 1 H), 4.25-4.36 (m, 3 H), 3.72-3.84 (m, 0.7 H), 3.36-3.48 (m, 0.3 H), 2.77-3.25 (m, 2 H) 434.2 [M+H] + 99.2%
1020 (CD 3OD) δ 7.68 (d, 1 H), 7.35-7.54 (m, 1.4 H), 7.04-7.19 (m, 1 H), 6.96 (s, 0.6 H), 6.67-6.75 (m, 1 H), 6.42-6.61 (m, 1 H), 4.92-4.99 (m, 1 H), 3.82-3.94 (m, 0.5 H), 3.34-3.40 (m, 0.5 H), 2.76-3.20 (m, 2 H), 2.57-2.70 (m, 3 H), 1.47 (d, 9 H) 406.2 [M+H] + 98.7%
1021 (CD 3OD) δ 7.68 (d, 1 H), 7.33-7.53 (m, 1.4 H), 7.05-7.18 (m, 1 H), 6.95 (s, 0.6 H), 6.66-6.75 (m, 1 H), 6.40-6.63 (m, 1 H), 4.92-4.99 (m, 1 H), 3.87 (br t, 0.5 H), 3.34-3.42 (m, 0.5 H), 2.77-3.19 (m, 2 H), 2.55-2.72 (m, 3 H), 1.47 (d, 9 H) 406.3 [M+H] + 95.3%
1022 (CD 3OD) δ 8.20-8.33 (m, 1 H), 7.69 (s, 1 H), 7.41 (s, 0.3 H), 6.91-7.04 (m, 1.7 H), 6.73-6.82 (m, 1 H), 6.50-6.66 (m, 1 H), 4.95 (br dd, 1 H), 3.69-3.78 (m, 0.5 H), 3.34-3.43 (m, 0.5 H), 2.92-3.20 (m, 1 H), 2.82 (br dd, 1 H), 2.38-2.50 (m, 3 H), 1.41-1.56 (m, 9 H) 406.2 [M+H] + 100%
1023 (CD 3OD) δ 8.22-8.32 (m, 1 H), 7.71-7.78 (m, 1 H), 7.42 (s, 0.3 H), 6.90-7.03 (m, 1.7 H), 6.72-6.83 (m, 1 H), 6.49-6.66 (m, 1 H), 4.96 (dd, 1 H), 3.67-3.80 (m, 0.6 H), 3.38 (td, 0.4 H), 2.90-3.21 (m, 1 H), 2.83 (br dd, 1 H), 2.36-2.50 (m, 3 H), 1.45-1.50 (m, 9 H) 406.2 [M+H] + 99.6%
1024 (CD 3OD) δ 8.27-8.36 (m, 1 H), 7.69 (s, 1 H), 7.41 (s, 0.4 H), 6.91-7.00 (m, 1.6 H), 6.78-6.88 (m, 1 H), 6.66-6.77 (m, 1 H), 4.94-4.99 (m, 1 H), 3.70-3.82 (m, 0.7 H), 3.37 (br s, 0.3 H), 2.83 (br dd, 2 H), 1.83-1.95 (m, 6 H) 414.2 [M+H] + 96.1%
1025 (CD 3OD) δ 8.26-8.40 (m, 1 H), 7.69 (s, 1 H), 7.41 (s, 0.4 H), 6.92-7.00 (m, 1.6 H), 6.79-6.87 (m, 1 H), 6.66-6.76 (m, 1 H), 4.93-5.00 (m, 1 H), 3.75 (br s, 1 H), 2.79-3.21 (m, 2 H), 1.79-1.95 (m, 6 H) 414.2 [M+H] + 95.0%
1026 (CD 3OD) δ 8.25-8.38 (m, 1 H), 7.69 (s, 1 H), 7.40 (br s, 0.3 H), 6.89-7.02 (m, 1.7 H), 6.78-6.88 (m, 1 H), 6.63-6.77 (m, 1 H), 4.91-5.03 (m, 1 H), 3.66-3.80 (m, 0.7 H), 3.35-3.44 (m, 0.3 H), 2.77-3.21 (m, 2 H), 1.45-1.51 (m, 9 H) 410.2 [M+H] + 100%
1027 (CD 3OD) δ 8.27-8.38 (m, 1 H), 7.69 (s, 1 H), 7.40 (br s, 0.3 H), 6.89-7.01 (m, 1.7 H), 6.78-6.87 (m, 1 H), 6.62-6.78 (m, 1 H), 4.90-5.01 (m, 1 H), 3.65-3.81 (m, 0.7 H), 3.35-3.42 (m, 0.3 H), 2.74-3.19 (m, 2 H), 1.44-1.52 (m, 9 H) 410.2 [M+H] + 100%
1028 (CD 3OD) δ 8.78 (t, 1 H), 8.31 (d, 1 H), 8.04-8.16 (m, 1 H), 7.80-7.91 (m, 1 H), 7.65-7.75 (m, 2 H), 7.54-7.61 (m, 0.5 H), 7.29 (br s, 2 H), 6.88 (s, 1 H), 6.68 (s, 0.5 H), 4.94-5.08 (m, 1 H), 3.90-4.07 (m, 0.5 H), 3.34-3.37 (m, 0.5 H), 2.84-3.26 (m, 2 H) 481.2 [M+H] + 100%
1029 (CD 3OD) δ 8.77 (t, 1 H), 8.30 (d, 1 H), 8.04-8.13 (m, 1 H), 7.78-7.90 (m, 1 H), 7.63-7.74 (m, 2 H), 7.57 (s, 0.5 H), 7.22-7.36 (m, 2 H), 6.85-7.01 (m, 1 H), 6.67 (s, 0.5 H), 4.93-5.04 (m, 1 H), 3.97 (br s, 0.5 H), 3.33-3.38 (m, 0.5 H), 2.83-3.25 (m, 2 H) 481.2 [M+H] + 99.8%
1030 (CD 3OD) δ 7.76-7.87 (m, 2 H), 7.69 (br d, 1 H), 7.58 (s, 0.5 H), 7.18-7.34 (m, 2 H), 6.82-6.99 (m, 2 H), 6.66 (s, 0.5 H), 4.96-5.08 (m, 1 H), 4.01 (d, 3.8 H), 3.36 (br d, 0.2 H), 3.17 (br s, 0.5 H), 2.96 (br dd, 0.5 H), 2.85 (br d, 1 H) 484.2 [M+H] + 100%
1031 (CD 3OD) δ 7.77-7.88 (m, 2 H), 7.54-7.59 (m, 1 H), 7.58 (s, 0.5 H), 7.20-7.34 (m, 2 H), 6.84-6.97 (m, 2 H), 6.66 (s, 0.5 H), 4.92-5.07 (m, 1 H), 4.01 (d, 3.8 H), 3.32-3.37 (m, 0.2 H), 3.10-3.21 (m, 0.5 H), 2.98 (s, 0.5 H), 2.81-2.89 (m, 1 H) 484.2 [M+H] + 100%
1032 (CD 3OD) δ 7.97 (d, 1 H), 7.80-7.90 (m, 2 H), 7.66-7.75 (m, 1 H), 7.54 (s, 0.5 H), 7.23-7.36 (m, 2 H), 6.85-6.99 (m, 1 H), 6.66 (s, 0.5 H), 5.08 (br dd, 0.5 H), 4.93-4.97 (m, 1 H), 4.09 (s, 3 H), 3.90-4.00 (m, 0.5 H), 2.94-3.04 (m, 1 H), 2.82-2.90 (m, 1 H) 484.2 [M+H] + 100%
1033 (CD 3OD) δ 7.97 (d, 1 H), 7.80-7.89 (m, 2 H), 7.79 (s, 1 H), 7.55 (s, 0.5 H), 7.22-7.36 (m, 2 H), 6.85-7.01 (m, 1 H), 6.68 (s, 0.5 H), 5.10 (dd, 0.5 H), 4.90-4.98 (m, 1 H), 4.09 (s, 3 H), 3.90-3.99 (m, 0.5 H), 2.94-3.04 (m, 1 H), 2.83-2.91 (m, 1 H) 484.2 [M+H] + 99.5%
1034 (CD 3OD) δ 8.60-8.74 (m, 1 H), 7.88-8.00 (m, 1.5 H), 7.73-7.86 (m, 2 H), 7.54-7.72 (m, 1 H), 7.24-7.39 (m, 2 H), 6.68-7.03 (m, 1.5 H), 5.02 (br d, 1 H), 3.92-4.07 (m, 0.5 H), 3.37-3.42 (m, 0.5 H), 2.86-3.23 (m, 2 H) 499.2 [M+H] + 100%
1035 (CD 3OD) δ 8.65 (t, 1 H), 7.87-7.98 (m, 1.5 H), 7.71-7.84 (m, 2 H), 7.52-7.69 (m, 1 H), 7.21-7.38 (m, 2 H), 6.66-7.00 (m, 1.5 H), 4.96 (br t, 1 H), 3.89-4.05 (m, 0.5 H), 3.34-3.41 (m, 0.5 H), 2.84-3.22 (m, 2 H) 499.2 [M+H] + 100%
1036 (CD 3OD) δ 8.34 (dd, 1 H), 7.50-7.91 (m, 3.5 H), 7.19-7.39 (m, 3 H), 6.65-7.01 (m, 1.5 H), 4.97-5.09 (m, 1 H), 3.88-4.07 (m, 0.5 H), 3.33-3.51 (m, 0.5 H), 2.85-3.22 (m, 2 H) 520.2 [M+H] + 98.0%
1037 (CD 3OD) δ 8.33 (dd, 1 H), 7.51-7.90 (m, 3.5 H), 7.19-7.38 (m, 3 H), 6.64-7.01 (m, 1.5 H), 4.94-5.04 (m, 1 H), 3.97 (br d, 0.5 H), 3.33-3.39 (m, 0.5 H), 2.85-3.21 (m, 2 H) 520.2 [M+H] + 98.8%
1038 (CD 3OD) δ 8.46-8.50 (m, 1 H), 8.23-8.33 (m, 1 H), 8.14 (s, 1 H), 7.69 (s, 1 H), 7.57 (s, 0.3 H), 6.93-7.02 (m, 1.7 H), 6.73-6.82 (m, 1 H), 6.53-6.66 (m, 1 H), 4.99-5.11 (m, 2 H), 3.71-3.83 (m, 0.6 H), 3.36-3.47 (m, 0.4 H), 3.11-3.23 (m, 0.7 H), 2.92-3.06 (m, 0.3 H), 2.78-2.90 (m, 1 H), 2.57-2.67 (m, 2 H), 2.47-2.57 (m, 2 H), 2.39-2.47 (m, 3 H), 1.85-2.00 (m, 2 H) 470.2 [M+H] + 100%
1039 (CD 3OD) δ 8.46-8.50 (m, 1 H), 8.23-8.33 (m, 1 H), 8.14 (s, 1 H), 7.69 (s, 1 H), 7.57 (s, 0.3 H), 6.93-7.02 (m, 1.7 H), 6.73-6.82 (m, 1 H), 6.53-6.66 (m, 1 H), 4.99-5.11 (m, 2 H), 3.71-3.83 (m, 0.6 H), 3.36-3.47 (m, 0.4 H), 3.11-3.23 (m, 0.7 H), 2.92-3.06 (m, 0.3 H), 2.78-2.90 (m, 1 H), 2.57-2.67 (m, 2 H), 2.47-2.57 (m, 2 H), 2.39-2.47 (m, 3 H), 1.85-2.00 (m, 2 H) 470.2 [M+H] + 98.5%
1040 (CD 3OD) δ 8.91 (d, 1 H), 8.35 (d, 1 H), 7.73-7.91 (m, 2 H), 7.64-7.68 (m, 1 H), 7.50-7.57 (m, 0.6 H), 7.24-7.37 (m, 2 H), 6.84-6.99 (m, 1 H), 6.66 (s, 0.4 H), 5.10 (br dd, 1 H), 3.91-4.02 (m, 1 H), 2.84-3.18 (m, 2 H) 520.1 [M+H] + 100%
1041 (CD 3OD) δ 8.89 (d, 1 H), 8.33 (d, 1 H), 7.69-7.89 (m, 2 H), 7.63-7.68 (m, 1 H), 7.48-7.55 (m, 0.6 H), 7.22-7.37 (m, 2 H), 6.83-6.98 (m, 1 H), 6.64 (s, 0.4 H), 5.09 (dd, 1 H), 3.87-4.02 (m, 1 H), 2.84-3.20 (m, 2 H) 520.1 [M+H] + 98.3%
1042 (CD 3OD) δ 8.76 (dd, 1 H), 8.24-8.35 (m, 1 H), 8.07 (tdd, 1 H), 7.54-7.71 (m, 3 H), 7.48 (s, 0.4 H), 7.10-7.21 (m, 1 H), 6.94-7.04 (m, 1.6 H), 6.60-6.81 (m, 1 H), 4.96-5.07 (m, 1 H), 3.88-3.95 (m, 0.5 H), 3.38 (td, 0.5 H), 2.82-3.23 (m, 2 H) 447.1 [M+H] + 100%
1043 (CD 3OD) δ 8.76 (dd, 1 H), 8.24-8.35 (m, 1 H), 8.07 (tdd, 1 H), 7.54-7.71 (m, 3 H), 7.48 (s, 0.4 H), 7.10-7.21 (m, 1 H), 6.94-7.04 (m, 1.6 H), 6.60-6.81 (m, 1 H), 4.96-5.07 (m, 1 H), 3.88-3.95 (m, 0.5 H), 3.38 (td, 0.5 H), 2.82-3.23 (m, 2 H) 447.1 [M+H] + 97.2%
1044 (CD 3OD) δ 8.71 (br d, 1 H), 7.94-8.05 (m, 1 H), 7.70 (d, 1 H), 7.58-7.66 (m, 1 H), 6.50-7.02 (m, 3 H), 4.91-4.96 (m, 0.5 H), 4.42 (dd, 0.5 H), 4.03-4.08 (m, 3 H), 3.66 (ddd, 0.6 H), 3.10-3.25 (m, 1 H), 2.93-3.03 (m, 0.4 H), 2.70-2.86 (m, 1 H) 417.1 [M+H] + 100%
1045 (CD 3OD) δ 8.71 (br d, 1 H), 7.96-8.03 (m, 1 H), 7.67-7.72 (m, 1 H), 7.58-7.65 (m, 1 H), 6.51-7.01 (m, 3 H), 4.91-4.96 (m, 0.4 H), 4.42 (dd, 0.6 H), 4.03-4.07 (m, 3 H), 3.66 (ddd, 0.6 H), 3.11-3.25 (m, 1 H), 2.93-3.02 (m, 0.4 H), 2.71-2.86 (m, 1 H) 417.2 [M+H] + 99.7%
1046 (CD 3OD) δ 8.36-8.47 (m, 1 H), 7.69 (br s, 1 H), 7.40 (br s, 0.2 H), 7.23-7.33 (m, 1 H), 6.92 (br s, 0.6 H), 6.80-6.88 (m, 1 H), 6.62-6.76 (m, 1 H), 4.95-5.01 (m, 1 H), 3.62-3.86 (m, 0.7 H), 3.33-3.41 (m, 0.4 H), 2.72-3.23 (m, 2 H), 1.42-1.52 (m, 9 H) 426.1 [M+H] + 100%
1047 (CD 3OD) δ 8.37-8.47 (m, 1 H), 7.70 (s, 1 H), 7.41 (br s, 0.2 H), 7.26-7.33 (m, 1 H), 6.93 (s, 0.5 H), 6.81-6.89 (m, 1 H), 6.65-6.77 (m, 1 H), 4.95-5.01 (m, 1 H), 3.66-3.80 (m, 0.7 H), 3.37-3.42 (m, 0.2 H), 2.79-3.22 (m, 2 H), 1.42-1.54 (m, 9 H) 426.1 [M+H] + 99.8%
1048 (CD 3OD) δ 8.25-8.38 (m, 1 H), 7.67 (d, 1 H), 7.24-7.40 (m, 1 H), 6.67-6.98 (m, 3 H), 6.48 (s, 0.6 H), 6.22 (s, 0.4 H), 4.42 (dd, 0.5 H), 4.05-4.13 (m, 3 H), 3.67 (ddd, 0.5 H), 2.91-3.30 (m, 2 H), 2.70-2.86 (m, 1 H), 2.30-2.39 (m, 3 H) 413.2 [M+H] + 100%
1049 (CD 3OD) δ 8.30-8.37 (m, 1 H), 7.69 (d, 1 H), 7.27-7.42 (m, 1 H), 6.69-7.00 (m, 3 H), 6.50 (s, 0.6 H), 6.24 (s, 0.4 H), 4.44 (dd, 0.5 H), 4.07-4.14 (m, 3 H), 3.69 (ddd, 0.5 H), 2.93-3.31 (m, 2 H), 2.72-2.88 (m, 1 H), 2.33-2.41 (m, 3 H) 413.2 [M+H] + 98.0%
1050 (CD 3OD) δ 8.40-8.47 (m, 1 H), 8.00 (s, 1 H), 7.69 (d, 1 H), 7.24-7.31 (m, 1 H), 6.80-6.95 (m, 2 H), 6.74 (s, 0.6 H), 6.47 (s, 0.4 H), 4.39 (m, 1 H), 4.03-4.07 (m, 3 H), 3.66 (m, 0.6 H), 3.08-3.26 (m, 1 H), 2.92-3.01 (m, 0.4 H), 2.69-2.85 (m, 1 H) 383.1 [M+H] + 99.9%
1051 (CD 3OD) δ 8.40-8.47 (m, 1 H), 7.99 (s, 1 H), 7.69 (d, 1 H), 7.24-7.31 (m, 1 H), 6.80-6.95 (m, 2 H), 6.73 (s, 0.6 H), 6.46 (s, 0.4 H), 4.39 (m, 1 H), 4.03-4.06 (m, 3 H), 3.65 (m, 0.6 H), 3.08-3.26 (m, 1 H), 2.91-3.01 (m, 0.4 H), 2.69-2.85 (m, 1 H) 383.1 [M+H] + 99.7%
1052 (CD 3OD) δ 8.40-8.49 (m, 1 H), 7.73 (s, 1 H), 7.23-7.34 (m, 1 H), 6.81-6.97 (m, 2 H), 6.75 (s, 0.6 H), 6.55 (s, 0.4 H), 4.92 (br s, 0.4 H), 4.49 (m, 0.6 H), 4.12-4.19 (m, 3 H), 3.69 (m, 0.6 H), 3.13-3.29 (m, 1 H), 2.94-3.04 (m, 0.4 H), 2.74-2.89 (m, 1 H) 451.1 [M+H] + 99.9%
1053 (CD 3OD) δ 8.40-8.48 (m, 1 H), 7.70 (d, 1 H), 7.25-7.33 (m, 1 H), 6.80-6.98 (m, 2 H), 6.74 (s, 0.6 H), 6.53 (s, 0.3 H), 4.92 (br s, 0.5 H), 4.47 (m, 0.5 H), 4.11-4.20 (m, 3 H), 3.68 (m, 0.6 H), 3.11-3.29 (m, 1 H), 2.94-3.03 (m, 0.4 H), 2.73-2.88 (m, 1 H) 451.1 [M+H] + 98.0%
1054 (CD 3OD) δ 8.44 (m, 1 H), 7.70 (d, 1 H), 7.24-7.32 (m, 1 H), 6.80-6.94 (m, 2 H), 6.73 (s, 0.6 H), 6.51 (s, 0.3 H), 4.48 (m, 0.1 H), 3.99-4.06 (m, 3 H), 3.66 (m, 0.6 H), 3.09-3.25 (m, 1 H), 2.91-3.02 (m, 0.4 H), 2.71-2.86 (m, 1 H) 417.1 [M+H] + 100%
1055 (CD 3OD) δ 8.44 (m, 1 H), 7.66-7.73 (m, 1 H), 7.24-7.32 (m, 1 H), 6.81-6.95 (m, 2 H), 6.73 (s, 0.6 H), 6.51 (s, 0.4 H), 4.48 (m, 1 H), 4.02-4.05 (m, 3 H), 3.66 (m, 0.6 H), 3.09-3.25 (m, 1 H), 2.92-3.02 (m, 0.3 H), 2.72-2.86 (m, 1 H) 417.1 [M+H] + 99.3%
1056 (CD 3OD) δ 8.22-8.38 (m, 1 H), 7.69 (d, 1 H), 6.85-7.05 (m, 2 H), 6.72-6.81 (m, 1 H), 6.36-6.66 (m, 1 H), 4.45 (dd, 1 H), 4.14 (s, 3 H), 3.69 (ddd, 0.6 H), 3.10-3.29 (m, 1 H), 2.66-3.07 (m, 1.4 H), 2.33-2.49 (m, 3 H) 431.2 [M+H] + 100%
1057 (CD 3OD) δ 8.30 (dd, 1 H), 7.69 (d, 1 H), 6.86-7.05 (m, 2 H), 6.73-6.82 (m, 1 H), 6.31-6.65 (m, 1 H), 4.45 (dd, 1 H), 4.14 (s, 3 H), 3.69 (ddd, 0.6 H), 3.09-3.26 (m, 1 H), 2.70-3.07 (m, 1.4 H), 2.37-2.46 (m, 3 H) 431.2 [M+H] + 99.5%
1058 (CD 3OD) δ 8.23-8.33 (m, 1 H), 7.68 (d, 1 H), 6.86-7.08 (m, 1.6 H), 6.69-6.84 (m, 1.4 H), 6.30-6.67 (m, 1 H), 4.84 (br s, 0.5 H), 4.31 (dd, 0.5 H), 3.93 (d, 3 H), 3.57-3.72 (m, 0.5 H), 2.91-3.29 (m, 1.5 H), 2.68-2.87 (m, 1 H), 2.36-2.49 (m, 3 H), 1.93-2.08 (m, 1 H), 0.86-1.02 (m, 4 H) 403.2 [M+H] + 99.2%
1059 (CD 3OD) δ 8.20-8.35 (m, 1 H), 7.69 (d, 1 H), 6.87-7.06 (m, 1.6 H), 6.78 (q, 1.4 H), 6.29-6.66 (m, 1 H), 4.85 (br d, 0.5 H), 4.31 (dd, 0.5 H), 3.93 (d, 3 H), 3.67 (ddd, 0.5 H), 3.05-3.29 (m, 1 H), 2.67-3.01 (m, 1.5 H), 2.36-2.48 (m, 3 H), 1.96-2.08 (m, 1 H), 0.88-1.02 (m, 4 H) 403.2 [M+H] + 98.5%
1060 (CD 3OD) δ 8.67-8.73 (m, 1 H), 7.70 (d, 1 H), 7.62 (dd, 1 H), 6.55-7.05 (m, 4 H), 4.94 (br s, 0.4 H), 4.48 (dd, 0.6 H), 4.07-4.15 (m, 3 H), 3.68 (ddd, 0.6 H), 3.13-3.27 (m, 1 H), 2.94-3.04 (m, 0.4 H), 2.73-2.87 (m, 1 H) 467.1 [M+H] + 100%
1061 (CD 3OD) δ 8.67-8.73 (m, 1 H), 7.70 (d, 1 H), 7.57-7.67 (m, 1 H), 6.55-7.04 (m, 4 H), 4.94 (br s, 0.4 H), 4.48 (dd, 0.6 H), 4.08-4.14 (m, 3 H), 3.63-3.72 (m, 0.6 H), 3.13-3.27 (m, 1 H), 2.94-3.04 (m, 0.4 H), 2.73-2.87 (m, 1 H) 467.2 [M+H] + 99.7%
1062 (CD 3OD) δ 8.67-8.73 (m, 1 H), 7.71 (d, 1 H), 7.57-7.68 (m, 1 H), 6.91-7.02 (m, 2 H), 6.62-6.82 (m, 1 H), 4.94-4.97 (m, 0.4 H), 4.50 (dd, 0.6 H), 4.11-4.20 (m, 3 H), 3.68 (ddd, 0.6 H), 3.13-3.29 (m, 1 H), 2.94-3.04 (m, 0.4 H), 2.74-2.87 (m, 1 H) 485.1 [M+H] + 99.9%
1063 (CD 3OD) δ 8.67-8.73 (m, 1 H), 7.70 (d, 1 H), 7.56-7.68 (m, 1 H), 6.89-7.03 (m, 2 H), 6.59-6.83 (m, 1 H), 4.93 (br s, 0.4 H), 4.49 (dd, 0.6 H), 4.10-4.20 (m, 3 H), 3.68 (ddd, 0.6 H), 3.12-3.29 (m, 1 H), 2.94-3.05 (m, 0.4 H), 2.73-2.88 (m, 1 H) 485.1 [M+H] + 98.8%
1064 (CD 3OD) δ 7.55-7.91 (m, 4 H), 6.92-7.35 (m, 3 H), 6.80 (br d, 1 H), 6.21-6.56 (m, 1 H), 4.04 (br dd, 1 H), 3.66-3.83 (m, 1 H), 2.70-3.04 (m, 2 H) 418.1 [M+H] + 98.4%
1065 (CD 3OD) δ 7.51-7.98 (m, 4 H), 6.91-7.38 (m, 3 H), 6.79 (br d, 1 H), 6.27-6.56 (m, 1 H), 4.03 (br dd, 1 H), 3.74 (br s, 1 H), 2.68-3.06 (m, 2 H) 418.1 [M+H] + 97.4%
1066 (CD 3OD) δ 8.39 (s, 1 H), 8.10 (s, 1 H), 7.69 (d, 1 H), 7.62 (d, 1.5 H), 7.12-7.23 (m, 1 H), 6.95-7.07 (m, 1.5 H), 6.61-6.80 (m, 1 H), 5.10 (br dd, 1 H), 3.98-4.04 (m, 3 H), 3.82-3.96 (m, 0.6 H), 3.34-3.44 (m, 0.4 H), 2.82-3.20 (m, 2 H) 450.1 [M+H] + 99.6%
1067 (CD 3OD) δ 8.37 (br s, 1 H), 8.08 (s, 1 H), 7.69 (br d, 1 H), 7.52-7.63 (m, 1.5 H), 7.10-7.21 (m, 1 H), 6.93-7.05 (m, 1.5 H), 6.60-6.80 (m, 1 H), 5.09 (br dd, 1 H), 3.99 (br d, 3 H), 3.84-3.94 (m, 0.6 H), 3.35-3.42 (m, 0.4 H), 2.81-3.18 (m, 2 H) 450.1 [M+H] + 94.0%
1068 (CD 3OD) δ 8.11-8.80 (m, 2 H), 7.53-7.75 (m, 2 H), 6.97-7.28 (m, 2 H), 6.43-6.90 (m, 2 H), 4.69-4.86 (m, 0.4 H), 4.21-4.39 (m, 0.6 H), 3.35-3.90 (m, 1 H), 2.71-3.16 (m, 2 H) 403.1 [M+H] + 99.4%
1069 (CD 3OD) δ 8.26-8.61 (m, 2 H), 7.52-7.79 (m, 2 H), 6.94-7.34 (m, 2 H), 6.44-6.91 (m, 2 H), 4.04-4.56 (m, 1 H), 3.35-3.86 (m, 1 H), 2.75-3.18 (m, 2 H) 403.1 [M+H] + 100%
1070 (CD 3OD) δ 8.51 (br d, 1 H), 7.51-7.77 (m, 2 H), 6.93-7.31 (m, 2 H), 6.68 (s, 2 H), 4.32 (br d, 1 H), 3.73 (br s, 1 H), 2.72-3.20 (m, 2 H), 1.57-1.68 (m, 6 H) 461.2 [M+H] + 100%
1071 (CD 3OD) δ 8.51 (br d, 1 H), 7.53-7.74 (m, 2 H), 6.95-7.33 (m, 2 H), 6.48-6.95 (m, 2 H), 4.11-4.47 (m, 1 H), 3.37-3.90 (m, 1 H), 2.76-3.19 (m, 2 H), 1.57-1.70 (m, 6 H) 461.2 [M+H] + 100%
1072 (CD 3OD) δ 8.44 (m, 1 H), 7.69 (d, 1 H), 7.29 (m, 1 H), 6.80-6.94 (m, 2 H), 6.73 (s, 0.5 H), 6.50 (s, 0.4 H), 4.82-4.85 (m, 0.5 H), 4.34 (m, 0.5 H), 3.94 (d, 3 H), 3.64 (m, 0.6 H), 3.22 (m, 0.4 H), 3.05-3.14 (m, 0.6 H), 2.91-3.01 (m, 0.4 H), 2.69-2.85 (m, 1 H), 1.98-2.06 (m, 1 H), 0.89-1.01 (m, 4 H) 423.2 [M+H] + 99.9%
1073 (CD 3OD) δ 8.45 (m, 1 H), 7.70 (d, 1 H), 7.30 (m, 1 H), 6.82-6.94 (m, 2 H), 6.74 (s, 0.5 H), 6.51 (s, 0.5 H), 4.86 (br s, 0.4 H), 4.34 (m, 0.6 H), 3.95 (d, 3 H), 3.65 (m, 0.6 H), 3.22 (m, 0.4 H), 3.05-3.15 (m, 0.6 H), 2.91-3.01 (m, 0.4 H), 2.70-2.86 (m, 1 H), 1.97-2.07 (m, 1 H), 0.90-1.01 (m, 4 H) 423.1 [M+H] + 99.8%
1074 (CD 3OD) δ 8.45 (m, 1 H), 7.70 (m, 1 H), 7.25-7.33 (m, 1 H), 6.80-6.98 (m, 2 H), 6.74 (s, 0.5 H), 6.45 (s, 0.4 H), 4.36 (m, 0.5 H), 3.96 (m, 3 H), 3.66 (m, 0.5 H), 2.70-3.23 (m, 2 H), 2.35 (m, 3 H) 397.2 [M+H] + 100%
1075 (CD 3OD) δ 8.45 (m, 1 H), 7.70 (d, 1 H), 7.29 (m, 1 H), 6.81-6.96 (m, 2 H), 6.74 (s, 0.6 H), 6.45 (s, 0.4 H), 4.36 (m, 0.5 H), 3.96 (d, 3 H), 3.61-3.71 (m, 0.5 H), 2.70-3.25 (m, 2 H), 2.33-2.38 (m, 3 H) 397.2 [M+H] + 99.4%
1076 (CD 3OD) δ 8.21-8.39 (m, 1 H), 7.69 (d, 1 H), 6.86-7.07 (m, 2 H), 6.73-6.84 (m, 1 H), 6.61 (s, 0.6 H), 6.36 (s, 0.4 H), 4.82-4.86 (m, 0.4 H), 4.45 (dd, 0.6 H), 3.91-4.09 (m, 3 H), 3.59-3.75 (m, 0.6 H), 3.06-3.29 (m, 1 H), 2.90-3.04 (m, 0.4 H), 2.68-2.86 (m, 1 H), 2.31-2.47 (m, 3 H) 397.1 [M+H] + 100%
1077 (CD 3OD) δ 8.20-8.39 (m, 1 H), 7.69 (br d, 1 H), 6.88-7.02 (m, 2 H), 6.78 (q, 1 H), 6.61 (s, 0.6 H), 6.36 (s, 0.4 H), 4.81-4.86 (m, 0.4 H), 4.45 (dd, 0.6 H), 3.98-4.07 (m, 3 H), 3.67 (ddd, 0.6 H), 3.08-3.29 (m, 1 H), 2.90-3.04 (m, 0.4 H), 2.70-2.88 (m, 1 H), 2.32-2.50 (m, 3 H) 397.1 [M+H] + 100%
1078 (CD 3OD) δ 8.70 (d, 1 H), 7.70 (d, 1 H), 7.57-7.67 (m, 1 H), 6.50-7.11 (m, 3 H), 4.97 (br s, 0.4 H), 4.49 (dd, 0.6 H), 3.97-4.13 (m, 3 H), 3.60-3.72 (m, 0.6 H), 3.09-3.24 (m, 1 H), 2.89-3.04 (m, 0.4 H), 2.70-2.88 (m, 1 H) 451.1 [M+H] + 100%
1079 (CD 3OD) δ 8.70 (br d, 1 H), 7.65-7.78 (m, 1 H), 7.57-7.65 (m, 1 H), 6.56-7.01 (m, 3 H), 4.97 (br s, 0.4 H), 4.50 (dd, 0.6 H), 4.01-4.06 (m, 3 H), 3.62-3.70 (m, 0.6 H), 3.09-3.25 (m, 1 H), 2.92-3.02 (m, 0.4 H), 2.69-2.87 (m, 1 H) 451.1 [M+H] + 99.2%
1080 (CD 3OD) δ 8.70 (dd, 1 H), 7.69 (d, 1 H), 7.59-7.66 (m, 1 H), 6.57-7.05 (m, 3 H), 4.86 (br s, 0.5 H), 4.35 (dd, 0.5 H), 3.94 (d, 3 H), 3.59-3.69 (m, 0.6 H), 3.05-3.27 (m, 1 H), 2.90-3.02 (m, 0.4 H), 2.70-2.86 (m, 1 H), 1.97-2.07 (m, 1 H), 0.89-1.00 (m, 4 H) 457.2 [M+H] + 97.0%
1081 (CD 3OD) δ 8.70 (dd, 1 H), 7.69 (d, 1 H), 7.62 (t, 1 H), 6.57-7.02 (m, 3 H), 4.94-5.00 (m, 0.5 H), 4.35 (dd, 0.5 H), 3.95 (d, 3 H), 3.59-3.69 (m, 0.6 H), 3.06-3.26 (m, 1 H), 2.90-3.02 (m, 0.4 H), 2.70-2.86 (m, 1 H), 1.98-2.06 (m, 1 H), 0.89-1.00 (m, 4 H) 457.2 [M+H] + 99.5%
1082 (CD 3OD) δ 8.71 (d, 1 H), 7.73 (d, 1 H), 7.58-7.66 (m, 1 H), 6.46-7.06 (m, 3 H), 4.94-4.97 (m, 0.5 H), 4.39 (dd, 0.5 H), 3.91-4.01 (m, 3 H), 3.61-3.71 (m, 0.6 H), 3.06-3.24 (m, 1 H), 2.91-3.02 (m, 0.4 H), 2.69-2.88 (m, 1 H), 2.31-2.40 (m, 3 H) 431.2 [M+H] + 100%
1083 (CD 3OD) δ 8.71 (d, 1 H), 7.70 (d, 1 H), 7.58-7.67 (m, 1 H), 6.41-7.07 (m, 3 H), 4.93 (br s, 0.5 H), 4.38 (dd, 0.5 H), 3.88-4.04 (m, 3 H), 3.59-3.71 (m, 0.6 H), 3.06-3.24 (m, 1 H), 2.91-3.02 (m, 0.4 H), 2.70-2.86 (m, 1 H), 2.35 (d, 3 H) 431.2 [M+H] + 99.6%
1084 (CD 3OD) δ 8.49 (dd, 1 H), 7.69 (s, 1 H), 6.99-7.32 (m, 2 H), 6.53-6.92 (m, 3 H), 4.35 (br d, 1 H), 3.74 (br s, 1 H), 2.97-3.23 (m, 1 H), 2.83 (br d, 1 H), 1.51-1.82 (m, 6 H) 461.2 [M+H] + 100%
1085 (CD 3OD) δ 8.49 (dd, 1 H), 7.69 (s, 1 H), 6.94-7.43 (m, 2 H), 6.48-6.88 (m, 3 H), 4.35 (br d, 1 H), 3.62-3.84 (m, 1 H), 2.94-3.24 (m, 1 H), 2.83 (br d, 1 H), 1.49-1.80 (m, 6 H) 461.2 [M+H] + 99.5%
1086 (CD 3OD) δ 7.69 (d, 1 H), 7.47 (dd, 1 H), 7.13 (dt, 1 H), 6.94 (s, 1 H), 6.73 (d, 1 H), 6.62 (s, 0.6 H), 6.34 (s, 0.4 H), 4.93 (br s, 0.5 H), 4.41 (dd, 0.5 H), 3.92-4.09 (m, 3 H), 3.72-3.86 (m, 0.5 H), 3.25-3.31 (m, 0.5 H), 3.08-3.21 (m, 0.7 H), 2.92-3.05 (m, 0.3 H), 2.73-2.90 (m, 1 H), 2.57-2.71 (m, 3 H) 397.1 [M+H] + 98.9%
1087 (CD 3OD) δ 7.69 (d, 1 H), 7.47 (dd, 1 H), 7.08-7.19 (m, 1 H), 6.94 (s, 1 H), 6.73 (d, 1 H), 6.62 (s, 0.5 H), 6.34 (s, 0.5 H), 4.97-4.98 (m, 0.5 H), 4.41 (dd, 0.5 H), 3.91-4.08 (m, 3 H), 3.73-3.86 (m, 0.5 H), 3.28 (br d, 0.5 H), 3.07-3.20 (m, 0.7 H), 2.92-3.04 (m, 0.3 H), 2.73-2.89 (m, 1 H), 2.60-2.72 (m, 3 H) 397.2 [M+H] + 96.9%
1088 (CD 3OD) δ 8.44-8.74 (m, 1 H), 7.48-7.87 (m, 4 H), 7.22 (br t, 1 H), 6.65-7.13 (m, 2 H), 6.19-6.53 (m, 1 H), 4.82 (br d, 0.7 H), 3.63-4.15 (m, 1 H), 3.16-3.27 (m, 0.3 H), 2.65-3.07 (m, 2 H) 402.1 [M+H] + 100%
1089 (CD 3OD) δ 8.33-8.76 (m, 1 H), 7.48-7.86 (m, 4 H), 7.22 (br t, 1 H), 6.64-7.13 (m, 2 H), 6.16-6.51 (m, 1 H), 4.73-4.85 (m, 0.7 H), 3.63-4.13 (m, 1 H), 3.17-3.27 (m, 0.3 H), 2.66-3.07 (m, 2 H) 402.1 [M+H] + 99.5%
1090 (CD 3OD) δ 8.69-8.87 (m, 1 H), 8.43-8.59 (m, 1 H), 8.24-8.39 (m, 1 H), 8.08 (td, 1 H), 7.41-7.88 (m, 3.4 H), 7.13-7.41 (m, 1 H), 6.49-7.08 (m, 1.6 H), 4.99 (br dd, 1 H), 3.37-3.92 (m, 1 H), 2.75-3.27 (m, 2 H) 431.2 [M+H] + 100%
1091 (CD 3OD) δ 8.74-8.83 (m, 1 H), 8.43-8.59 (m, 1 H), 8.27-8.37 (m, 1 H), 8.08 (td, 1 H), 7.45-7.83 (m, 3.4 H), 7.11-7.32 (m, 1 H), 6.59-7.01 (m, 1.6 H), 5.00 (br dd, 1 H), 3.36-3.89 (m, 1 H), 2.76-3.25 (m, 2 H) 431.1 [M+H] + 99.2%
1092 (CD 3OD) δ 8.41-8.68 (m, 1 H), 7.49-7.89 (m, 3 H), 7.26-7.44 (m, 1 H), 6.18-7.10 (m, 4 H), 4.82-4.86 (m, 0.4 H), 3.99-4.18 (m, 0.6 H), 3.72 (br t, 0.6 H), 2.95-3.31 (m, 1.4 H), 2.76 (br d, 1 H) 402.2 [M+H] + 100%
1093 (CD 3OD) δ 8.30-8.53 (m, 1 H), 7.38-7.79 (m, 3 H), 7.10-7.29 (m, 1 H), 6.10-7.00 (m, 4 H), 4.69-4.75 (m, 0.4 H), 3.91-4.05 (m, 0.6 H), 3.60 (br t, 0.6 H), 2.84-3.19 (m, 1.4 H), 2.64 (br d, 1 H) 402.1 [M+H] + 99.9%
1094 (CD 3OD) δ 8.40-8.46 (m, 1 H), 7.70 (s, 1 H), 7.46 (s, 0.3 H), 7.27-7.33 (m, 1 H), 6.91 (s, 0.6 H), 6.82-6.88 (m, 1 H), 6.67-6.74 (m, 1 H), 5.00 (dd, 0.4 H), 3.68-3.75 (m, 0.6 H), 3.26-3.40 (m, 0.2 H), 3.13-2.79 (m, 1 H), 2.82 (br dd, 1 H), 2.28-2.36 (m, 1 H), 1.18-1.31 (m, 4 H) 410.1 [M+H] + 100%
1095 (CD 3OD) δ 8.40-8.46 (m, 1 H), 7.70 (s, 1 H), 7.46 (s, 0.3 H), 7.27-7.33 (m, 1 H), 6.91 (s, 0.6 H), 6.82-6.88 (m, 1 H), 6.67-6.74 (m, 1 H), 4.98-5.03 (m, 0.5 H), 3.68 – 3.75 (m, 1 H), 3.36-3.41 (m, 0.3 H), 2.91-3.18 (m, 1 H), 2.79-2.84 (m, 1 H), 2.28-2.36 (m, 1 H), 1.18-1.31 (m, 4 H) 410.1 [M+H] + 100%
1096 (CD 3OD) δ 8.44 (t, 1 H), 8.26 (dd, 1 H), 7.71 (d, 1 H), 7.55-7.66 (m, 2 H), 7.52 (s, 0.4 H), 7.13-7.24 (m, 1 H), 6.97-7.08 (m, 1.6 H), 6.61-6.83 (m, 1 H), 5.06 (br dd, 1 H), 4.00 (d, 3 H), 3.87-3.98 (m, 0.6 H), 3.36-3.45 (m, 0.4 H), 2.84-3.24 (m, 2 H) 477.1 [M+H] + 100%
1097 (CD 3OD) δ 8.45 (d, 1 H), 8.27 (dd, 1 H), 7.71 (d, 1 H), 7.59-7.67 (m, 2 H), 7.52 (s, 0.5 H), 7.15-7.22 (m, 1 H), 6.99-7.07 (m, 1.5 H), 6.60-6.85 (m, 1 H), 5.03-5.08 (m, 1 H), 4.00 (d, 3 H), 3.94 (br d, 1 H), 2.87-3.23 (m, 2 H) 477.2 [M+H] + 100%
1098 (CD 3OD) δ 7.98 (s, 1 H), 7.84 (dd, 1 H), 7.71 (d, 1 H), 7.48-7.66 (m, 1.5 H), 7.13-7.25 (m, 1 H), 6.97-7.06 (m, 1.5 H), 6.63-6.82 (m, 1 H), 5.10 (br dd, 1 H), 4.11 (s, 3 H), 3.87-3.99 (m, 0.6 H), 3.37-3.47 (m, 0.4 H), 2.87 (br dd, 2 H) 450.1 [M+H] + 98.1%
1099 (CD 3OD) δ 7.86 (s, 1 H), 7.72 (d, 1 H), 7.59 (d, 1 H), 7.36-7.54 (m, 1.5 H), 7.01-7.12 (m, 1 H), 6.85-6.94 (m, 1.5 H), 6.52-6.70 (m, 1 H), 4.87-5.04 (m, 1 H), 3.99 (s, 3 H), 3.75-3.89 (m, 0.6 H), 3.24-3.30 (m, 0.4 H), 2.73-3.12 (m, 2 H) 450.1 [M+H] + 94.5%
1100 (CD 3OD) δ 8.45-8.57 (m, 1 H), 8.38 (s, 1 H), 8.09 (s, 1 H), 7.51-7.75 (m, 2.4 H), 7.13-7.31 (m, 1 H), 6.92 (s, 0.6 H), 6.55-6.75 (m, 1 H), 5.05 (br dd, 1 H), 4.00 (s, 3 H), 3.34-3.81 (m, 1 H), 2.76-3.22 (m, 2 H) 434.2 [M+H] + 99.4%
1101 (CD 3OD) δ 8.45-8.54 (m, 1 H), 8.38 (s, 1 H), 8.09 (s, 1 H), 7.54-7.70 (m, 2.4 H), 7.12-7.28 (m, 1 H), 6.92 (s, 0.6 H), 6.54-6.76 (m, 1 H), 5.05 (br dd, 1 H), 4.00 (s, 3 H), 3.34-3.82 (m, 1 H), 2.76-3.22 (m, 2 H) 434.2 [M+H] + 98.8%
1102 (CD 3OD) δ 8.34-8.60 (m, 1 H), 7.81 (d, 1 H), 7.68 (s, 2 H), 7.50 (s, 0.4 H), 7.11-7.27 (m, 1 H), 6.86-7.01 (m, 1.6 H), 6.52-6.75 (m, 1 H), 5.00 (br dd, 0.7 H), 3.92-4.10 (m, 3 H), 3.35-3.83 (m, 1.3 H), 2.77-3.22 (m, 2 H) 434.2 [M+H] + 100%
1103 (CD 3OD) δ 8.37-8.62 (m, 1 H), 7.81 (d, 1 H), 7.56-7.72 (m, 2 H), 7.50 (s, 0.4 H), 7.12-7.28 (m, 1 H), 6.80-7.07 (m, 1.6 H), 6.56-6.75 (m, 1 H), 5.00 (br dd, 0.7 H), 3.92-4.07 (m, 3 H), 3.34-3.85 (m, 1.3 H), 2.80-3.22 (m, 2 H) 434.1 [M+H] + 100%
1104 (CD 3OD) δ 8.92 (s, 1 H), 8.42 (s, 1 H), 7.65-7.82 (m, 2 H), 7.35 (br d, 1 H), 6.99-7.28 (m, 1 H), 6.53-6.90 (m, 2 H), 4.34 (br d, 1 H), 3.66-3.80 (m, 0.7 H), 3.34-3.49 (m, 0.3 H), 2.93-3.16 (m, 1 H), 2.80 (br d, 1 H) 453.1 [M+H] + 99.6%
1105 (CD 3OD) δ 8.92 (s, 1 H), 8.42 (s, 1 H), 7.63-7.86 (m, 2 H), 7.35 (d, 1 H), 6.99-7.28 (m, 1 H), 6.47-6.92 (m, 2 H), 4.34 (br d, 1 H), 3.74 (br t, 0.7 H), 3.35-3.48 (m, 0.3 H), 2.91-3.15 (m, 1 H), 2.79 (br d, 1 H) 453.1 [M+H] + 98.6%
1106 (CD 3OD) δ 8.38-8.45 (m, 1 H), 7.69 (s, 1 H), 7.47 (s, 0.3 H), 7.24-7.32 (m, 1 H), 6.67-6.93 (m, 2.7 H), 4.96 (dd, 1 H), 3.68-3.77 (m, 0.7 H), 3.33-3.42 (m, 0.3 H), 2.91-3.17 (m, 1 H), 2.79 – 2.84 (m, 1 H), 2.60-2.66 (m, 3 H) 384.1 [M+H] + 100%
1107 (CD 3OD) δ 8.40-8.46 (m, 1 H), 7.71 (s, 1 H), 7.47 (s, 0.3 H), 7.26-7.32 (m, 1 H), 6.68-6.94 (m, 2.7 H), 4.94 – 4.99 (m, 1 H), 3.68-3.77 (m, 0.7 H), 3.33-3.41 (m, 0.4 H), 2.91-3.19 (m, 1 H), 2.79 – 2.84 (m, 1 H), 2.60-2.66 (m, 3 H) 384.2 [M+H] + 99.5%
1108 (CD 3OD) δ 8.38-8.47 (m, 1 H), 7.70 (s, 1 H), 7.40 (s, 0.3 H), 6.93 (s, 0.6 H), 6.64-6.88 (m, 2 H), 4.97 (br dd, 1 H), 3.74 (ddd, 0.6 H), 3.36-3.42 (m, 0.3 H), 2.80-3.21 (m, 2 H), 1.83-1.95 (m, 6 H) 430.1 [M+H] + 100%
1109 (CD 3OD) δ 8.37-8.47 (m, 1 H), 7.69 (s, 1 H), 7.40 (s, 0.3 H), 7.27-7.33 (m, 1 H), 6.93 (s, 0.6 H), 6.63-6.88 (m, 2 H), 4.92-4.99 (m, 1 H), 3.67-3.78 (m, 0.7 H), 3.34-3.42 (m, 0.4 H), 2.80-3.16 (m, 2 H), 1.84-1.93 (m, 6 H) 430.1 [M+H] + 99.4%
1110 (CD 3OD) δ 8.17-8.29 (m, 1 H), 7.67 (s, 1 H), 7.44-7.53 (m, 1 H), 7.39 (br s, 0.3 H), 7.02-7.11 (m, 1 H), 6.91 (br s, 0.7 H), 6.54 (s, 0.7 H), 6.45 (s, 0.3 H), 4.90-5.00 (m, 1 H), 3.72 (td, 0.7 H), 3.33-3.42 (m, 0.3 H), 3.07-3.21 (m, 0.7 H), 2.91-3.02 (m, 0.3 H), 2.81 (br d, 1 H), 2.26-2.36 (m, 3 H), 1.47 (s, 9 H) 406.2 [M+H] + 100%
1111 (CD 3OD) δ 8.16-8.33 (m, 1 H), 7.69 (d, 1 H), 7.43-7.53 (m, 1 H), 7.40 (s, 0.3 H), 7.04-7.13 (m, 1 H), 6.91 (s, 0.7 H), 6.43-6.59 (m, 1 H), 4.91-4.97 (m, 1 H), 3.68-3.77 (m, 0.7 H), 3.33-3.43 (m, 0.3 H), 3.06-3.19 (m, 0.7 H), 2.90-3.02 (m, 0.3 H), 2.81 (br d, 1 H), 2.28-2.35 (m, 3 H), 1.47 (s, 9 H) 406.2 [M+H] + 99.8%
1112 (CDCl 3) δ 8.12-8.29 (m, 1 H), 7.30-7.80 (m, 4 H), 6.96 (br d, 2 H), 6.43-6.63 (m, 1 H), 6.34 (br d, 1 H), 4.00-4.97 (m, 1 H), 3.23-3.80 (m, 1 H), 2.86-3.12 (m, 1 H), 2.67-2.78 (m, 1 H), 2.32 (br s, 3 H) 398.2 [M+H] + 98.6%
1113 (CDCl 3) δ 8.13-8.27 (m, 1 H), 7.31-7.80 (m, 4 H), 6.90-7.03 (m, 2 H), 6.39-6.67 (m, 1 H), 6.34 (br d, 1 H), 4.04-4.95 (m, 1 H), 3.24-3.83 (m, 1 H), 2.87-3.13 (m, 1 H), 2.65-2.80 (m, 1 H), 2.32 (br s, 3 H) 398.2 [M+H] + 100%
1114 (CD 3OD) δ 8.40-8.59 (m, 1 H), 7.53-7.78 (m, 2 H), 7.39 (s, 0.3 H), 7.13-7.30 (m, 1 H), 6.91 (s, 0.7 H), 6.47-6.78 (m, 1 H), 4.92-4.98 (m, 1 H), 3.36-3.81 (m, 1 H), 2.75-3.21 (m, 2 H), 1.82-1.96 (m, 6 H) 414.2 [M+H] + 100%
1115 (CD 3OD) δ 8.36-8.59 (m, 1 H), 7.55-7.74 (m, 2 H), 7.39 (s, 0.4 H), 7.14-7.28 (m, 1 H), 6.91 (s, 0.6 H), 6.54-6.76 (m, 1 H), 4.92-4.99 (m, 1 H), 3.35-3.79 (m, 1 H), 2.75-3.21 (m, 2 H), 1.84-1.95 (m, 6 H) 414.2 [M+H] + 99.4%
1116 (CD 3OD) δ 8.92 (s, 1 H), 7.77 (br d, 1 H), 7.68 (s, 1 H), 7.35 (br d, 1 H), 6.97-7.27 (m, 1 H), 6.78-6.87 (m, 1.6 H), 6.61 (br s, 0.4 H), 4.82 (br s, 0.4 H), 4.32-4.41 (m, 0.6 H), 3.74 (br t, 0.6 H), 3.36-3.49 (m, 0.4 H), 2.74-3.20 (m, 2 H), 1.55-1.69 (m, 6 H) 511.2 [M+H] + 100%
1117 (CD 3OD) δ 8.92 (s, 1 H), 7.77 (br d, 1 H), 7.68 (s, 1 H), 7.35 (d, 1 H), 6.97-7.27 (m, 1 H), 6.79-6.87 (m, 1.7 H), 6.61 (br d, 0.3 H), 4.81 (br s, 0.3 H), 4.36 (br d, 0.7 H), 3.69-3.79 (m, 0.7 H), 3.34-3.49 (m, 0.3 H), 2.77-3.18 (m, 2 H), 1.55-1.68 (m, 6 H) 511.2 [M+H] + 98.5%
1118 (CD 3OD) δ 8.31-8.48 (m, 2 H), 7.83 (s, 0.2 H), 7.49-7.72 (m, 2 H), 7.19-7.33 (m, 2 H), 6.70-6.99 (m, 2.6 H), 4.99-5.08 (m, 1 H), 3.72-3.83 (m, 0.6 H), 3.41 (td, 0.4 H), 2.94-3.25 (m, 1 H), 2.80-2.90 (m, 1 H) 486.2 [M+H] + 100%
1119 (CD 3OD) δ 8.29-8.48 (m, 2 H), 7.82 (s, 0.2 H), 7.49-7.74 (m, 2 H), 7.18-7.35 (m, 2 H), 6.69-6.99 (m, 2.8 H), 5.02 – 5.07 (m, 1 H), 3.72-3.82 (m, 0.7 H), 3.37 – 3.44 (m, 0.3 H), 2.96-3.26 (m, 1 H), 2.83 – 2.87 (m, 1 H) 486.1 [M+H] + 99.8%
1120 (CD 3OD) δ 8.93 (s, 1 H), 8.36 (s, 1 H), 7.51-7.74 (m, 3.4 H), 7.14-7.23 (m, 1 H), 6.98-7.08 (m, 1.6 H), 6.64-6.82 (m, 1 H), 5.11 (dd, 1 H), 3.88-3.97 (m, 0.6 H), 3.37-3.44 (m, 0.4 H), 2.99-3.24 (m, 1 H), 2.88 (dd, 1 H) 486.1 [M+H] + 100%
1121 (CD 3OD) δ 8.81 (s, 1 H), 8.24 (s, 1 H), 7.38-7.64 (m, 3.4 H), 7.02-7.12 (m, 1 H), 6.86-6.95 (m, 1.6 H), 6.53-6.70 (m, 1 H), 5.00 (br dd, 1 H), 3.74-3.86 (m, 0.6 H), 3.25-3.34 (m, 0.4 H), 2.86-3.13 (m, 1 H), 2.76 (dd, 1 H) 486.1 [M+H] + 100%
1122 (CD 3OD) δ 7.59 (d, 1 H), 7.45-7.54 (m, 1 H), 7.34 (s, 0.4 H), 7.04-7.12 (m, 1 H), 6.91-6.97 (m, 1 H), 6.86 (s, 0.6 H), 6.51-6.71 (m, 1 H), 4.89 (br dd, 1 H), 3.71-3.81 (m, 0.6 H), 3.25-3.32 (m, 0.4 H), 2.71-3.10 (m, 2 H), 1.37-1.39 (m, 9 H) 426.2 [M+H] + 100%
1123 (CD 3OD) δ 7.70 (d, 1 H), 7.57-7.65 (m, 1 H), 7.44 (s, 0.4 H), 7.16-7.23 (m, 1 H), 7.02-7.07 (m, 1 H), 6.97 (s, 0.6 H), 6.63-6.81 (m, 1 H), 5.00 (dd, 1 H), 3.81-3.93 (m, 0.6 H), 3.36-3.43 (m, 0.4 H), 2.81-3.21 (m, 2 H), 1.47-1.50 (m, 9 H) 426.2 [M+H] + 98.0%
1124 (CD 3OD) δ 8.39-8.55 (m, 1 H), 7.53-7.72 (m, 2 H), 7.39 (s, 0.3 H), 7.13-7.28 (m, 1 H), 6.90 (s, 0.7 H), 6.58-6.73 (m, 1 H), 4.96 (br s, 1 H), 3.68-3.77 (m, 0.7 H), 3.34-3.41 (m, 0.3 H), 2.78-3.18 (m, 2 H), 1.47 (s, 9 H) 410.2 [M+H] + 100%
1125 (CD 3OD) δ 8.39-8.61 (m, 1 H), 7.52-7.75 (m, 2 H), 7.39 (s, 0.3 H), 7.14-7.27 (m, 1 H), 6.90 (s, 0.7 H), 6.56-6.72 (m, 1 H), 4.96 (br d, 1 H), 3.63-3.81 (m, 0.7 H), 3.36-3.41 (m, 0.3 H), 2.74-3.21 (m, 2 H), 1.47 (s, 9 H) 410.2 [M+H] + 99.7%
1126 (CD 3OD) δ 8.90-8.96 (m, 1 H), 7.68-7.80 (m, 2 H), 7.31-7.37 (m, 1 H), 6.93-6.98 (m, 1 H), 6.79-6.85 (m, 1 H), 6.69-6.72 (m, 0.5 H), 6.62 (s, 0.5 H), 4.93 (br d, 0.4 H), 4.48 (dd, 0.6 H), 4.07-4.13 (m, 3 H), 3.68 (ddd, 0.6 H), 3.11-3.28 (m, 1 H), 2.93-3.04 (m, 0.4 H), 2.71-2.86 (m, 1 H) 467.1 [M+H] + 100%
1127 (CD 3OD) δ 8.93 (br d, 1 H), 7.66-7.81 (m, 2 H), 7.31-7.38 (m, 1 H), 6.92-6.98 (m, 1 H), 6.79-6.85 (m, 1 H), 6.69-6.72 (m, 0.5 H), 6.62 (s, 0.5 H), 4.90-4.95 (m, 0.7 H), 4.48 (dd, 0.3 H), 4.08-4.12 (m, 3 H), 3.68 (ddd, 0.6 H), 3.12-3.28 (m, 1 H), 2.94-3.04 (m, 0.4 H), 2.71-2.86 (m, 1 H) 467.1 [M+H] + 100%
1128 (CD 3OD) δ 8.85-8.96 (m, 1 H), 7.67-7.84 (m, 3 H), 7.51 (s, 0.2 H), 7.31-7.38 (m, 0.8 H), 6.94-7.00 (m, 2 H), 6.76-6.83 (m, 1 H), 5.05 (br dd, 0.6 H), 4.95 (br d, 0.4 H), 4.03 (s, 3 H), 3.74-3.84 (m, 0.6 H), 3.36-3.46 (m, 0.4 H), 3.12-3.24 (m, 0.7 H), 2.94-3.06 (m, 0.3 H), 2.83 (br d, 1 H) 484.2 [M+H] + 89.9%
1129 (CD 3OD) δ 8.86-8.97 (m, 1 H), 7.68-7.83 (m, 3 H), 7.51 (br s, 0.3 H), 7.31-7.39 (m, 0.7 H), 6.93-7.01 (m, 2 H), 6.75-6.85 (m, 1 H), 5.05 (br dd, 0.7 H), 4.95 (br d, 0.3 H), 4.03 (s, 3 H), 3.74-3.84 (m, 0.7 H), 3.36-3.50 (m, 0.3 H), 3.10-3.24 (m, 0.8 H), 2.93-3.06 (m, 0.2 H), 2.79-2.88 (m, 1 H) 484.2 [M+H] + 94.9%
1130 (CD 3OD) δ 8.38-8.52 (m, 1 H), 7.23-7.74 (m, 2.3 H), 6.71-6.95 (m, 1.7 H), 6.51-6.67 (m, 1 H), 4.97-5.04 (m, 1 H), 3.73 (ddd, 0.6 H), 3.37-3.42 (m, 0.4 H), 2.91-3.20 (m, 1 H), 2.75-2.86 (m, 1 H), 2.24-2.41 (m, 1 H), 1.17-1.33 (m, 4 H) 394.1 [M+H] + 99.9%
1131 (CD 3OD) δ 8.38-8.55 (m, 1 H), 7.25-7.82 (m, 2.3 H), 6.75-7.01 (m, 1.7 H), 6.49-6.63 (m, 1 H), 4.96-5.06 (m, 1 H), 3.73 (ddd, 0.6 H), 3.35-3.43 (m, 0.4 H), 2.90-3.21 (m, 1 H), 2.74-2.88 (m, 1 H), 2.21-2.45 (m, 1 H), 1.20-1.38 (m, 4 H) 394.2 [M+H] + 99.9%
1132 (CD 3OD) δ 8.57-8.79 (m, 1 H), 8.04 (br d, 1 H), 7.44-7.87 (m, 3 H), 6.58-7.15 (m, 3.6 H), 6.31 (br s, 0.4 H), 4.82 (br s, 0.5 H), 4.09 (br dd, 0.5 H), 3.71 (br t, 0.5 H), 3.15-3.30 (m, 0.5 H), 2.68-3.06 (m, 2 H) 452.2 [M+H] + 100%
1133 (CD 3OD) δ 8.58-8.79 (m, 1 H), 8.04 (br d, 1 H), 7.46-7.88 (m, 3 H), 6.58-7.17 (m, 3.6 H), 6.31 (br s, 0.4 H), 4.82 (br s, 0.5 H), 4.09 (br dd, 0.5 H), 3.65-3.78 (m, 0.5 H), 3.17-3.29 (m, 0.5 H), 2.66-3.09 (m, 2 H) 452.1 [M+H] + 99.7%
1134 (CD 3OD) δ 8.90 (br s, 1 H), 8.30-8.48 (m, 2 H), 7.49-7.80 (m, 2 H), 7.22-7.33 (m, 1 H), 6.66-6.98 (m, 3 H), 5.03-5.11 (m, 1 H), 3.77 (br t, 0.7 H), 3.35-3.45 (m, 0.3 H), 3.11-3.23 (m, 1 H), 2.78-3.03 (m, 1 H) 486.1 [M+H] + 100%
1135 (CD 3OD) δ 8.90 (s, 1 H), 8.31-8.46 (m, 2 H), 7.47-7.81 (m, 2 H), 7.24-7.32 (m, 1 H), 6.69-6.99 (m, 3 H), 5.07 (br dd, 1 H), 3.71-3.82 (m, 0.7 H), 3.40 (td, 0.3 H), 3.12-3.23 (m, 1 H), 2.79-3.04 (m, 1 H) 486.1 [M+H] + 98.3%
1136 (CD 3OD) δ 7.82-7.92 (m, 1 H), 7.46-7.56 (m, 1 H), 7.40 (s, 0.3 H), 7.04-7.14 (m, 1 H), 6.85-6.97 (m, 1.7 H), 6.56-6.73 (m, 1 H), 4.95 (br dd, 1 H), 3.66-3.77 (m, 0.6 H), 3.24-3.32 (m, 0.4 H), 2.84-3.08 (m, 1 H), 2.70-2.81 (m, 1 H), 2.16-2.29 (m, 1 H), 1.15-1.19 (m, 2 H), 1.08-1.13 (m, 2 H) 410.1 [M+H] + 99.5%
1137 (CD 3OD) δ 7.60 (d, 1 H), 7.49 (dd, 1 H), 7.34 (s, 0.3 H), 7.03-7.11 (m, 1 H), 6.81-6.96 (m, 1.7 H), 6.50-6.69 (m, 1 H), 4.89 (br d, 1 H), 3.67-3.83 (m, 0.6 H), 3.26 (br s, 0.4 H), 3.02 (br d, 1 H), 2.72 (br dd, 1 H), 2.17-2.25 (m, 1 H), 1.14-1.19 (m, 2 H), 1.07-1.14 (m, 2 H) 410.1 [M+H] + 99.7%
1138 (CD 3OD) δ 8.87-9.07 (m, 1 H), 7.50-7.82 (m, 4 H), 7.35 (dd, 1 H), 6.89-7.09 (m, 1 H), 6.80 (br d, 1 H), 6.23-6.62 (m, 1 H), 4.78-4.84 (m, 0.5 H), 4.10 (br dd, 0.5 H), 3.72 (br t, 0.5 H), 3.21-3.30 (m, 0.5 H), 2.93-3.06 (m, 1 H), 2.75 (br d, 1 H) 452.1 [M+H] + 100%
1139 (CD 3OD) δ 8.87-9.09 (m, 1 H), 7.48-7.85 (m, 4 H), 7.35 (dd, 1 H), 6.90-7.09 (m, 1 H), 6.80 (br d, 1 H), 6.24-6.60 (m, 1 H), 4.77-4.83 (m, 0.5 H), 4.10 (br dd, 0.5 H), 3.72 (br t, 0.5 H), 3.21-3.30 (m, 0.5 H), 2.94-3.06 (m, 1 H), 2.75 (br d, 1 H) 452.1 [M+H] + 100%
1140 (CD 3OD) δ 7.74 (dd, 1 H), 7.51-7.65 (m, 1 H), 7.40 (s, 0.5 H), 7.11-7.29 (m, 2 H), 6.67-6.94 (m, 1 H), 6.53 (s, 0.5 H), 4.89 (br s, 1 H), 3.61-3.95 (m, 0.5 H), 2.67-3.19 (m, 2.5 H), 2.05-2.34 (m, 1 H), 1.09-1.21 (m, 4 H) 444.2 [M+H] + 100%
1141 (CD 3OD) δ 7.74 (dd, 1 H), 7.51-7.64 (m, 1 H), 7.21-7.44 (m, 1.5 H), 7.10-7.21 (m, 1 H), 6.81 (s, 0.5 H), 6.44-6.77 (m, 1 H), 4.90 (br dd, 1 H), 3.73-3.87 (m, 0.5 H), 2.68-3.18 (m, 2.5 H), 2.13-2.36 (m, 1 H), 1.09-1.20 (m, 4 H) 444.1 [M+H] + 97.6%
1142 (CD 3OD) δ 7.72 (d, 1 H), 7.55-7.66 (m, 1 H), 7.16-7.24 (m, 1 H), 7.02-7.11 (m, 1 H), 6.93 (s, 1 H), 6.48-6.84 (m, 1 H), 4.41 (br dd, 0.7 H), 4.06 (d, 3 H), 3.71-3.82 (m, 0.7 H), 2.79-3.22 (m, 2.6 H) 417.1 [M+H] + 99.4%
1143 (CD 3OD) δ 7.60 (br d, 1 H), 7.43-7.53 (m, 1 H), 7.02-7.11 (m, 1 H), 6.94 (d, 1 H), 6.81 (s, 1 H), 6.37-6.69 (m, 1 H), 4.28 (br dd, 0.7 H), 3.94 (d, 3 H), 3.59-3.69 (m, 0.7 H), 2.62-3.12 (m, 2.6 H) 417.1 [M+H] + 97.7%
1144 (CD 3OD) δ 8.02 (d, 1 H), 7.79-7.94 (m, 1 H), 7.72 (d, 1 H), 7.38 (d, 1 H), 7.18-7.32 (m, 1 H), 6.94-7.08 (m, 1 H), 6.88 (s, 0.5 H), 6.55 (s, 0.5 H), 4.99 (br s, 0.6 H), 4.23-4.29 (m, 0.4 H), 4.03 (d, 3 H), 3.75 (td, 0.6 H), 2.69-3.30 (m, 2.4 H) 417.2 [M+H] + 99.3%
1145 (CD 3OD) δ 7.90 (d, 1 H), 7.67-7.80 (m, 1 H), 7.59 (d, 1 H), 7.23-7.30 (m, 1 H), 7.10-7.22 (m, 1 H), 6.81-6.99 (m, 1 H), 6.76 (s, 0.5 H), 6.42 (s, 0.5 H), 4.86 (br d, 0.5 H), 4.14 (br dd, 0.5 H), 3.91 (d, 3 H), 3.58-3.67 (m, 0.5 H), 2.57-3.18 (m, 2.5 H) 417.2 [M+H] + 99.3%
1146 (CD 3OD) δ 8.39-8.64 (m, 1 H), 7.65-7.76 (m, 1 H), 7.41-7.56 (m, 1 H), 7.08-7.19 (m, 1 H), 6.93 (s, 0.7 H), 6.73 (d, 1 H), 6.59 (s, 0.7 H), 6.36 (s, 0.3 H), 6.09 (s, 0.3 H), 3.76-3.94 (m, 1.5 H), 3.43-3.57 (m, 0.5 H), 2.74-3.04 (m, 2 H), 2.62-2.72 (m, 3 H) 417.1 [M+H] + 99.8%
1147 (CD 3OD) δ 8.35-8.64 (m, 1 H), 7.64-7.75 (m, 1 H), 7.38-7.56 (m, 1 H), 7.05-7.20 (m, 1 H), 6.93 (s, 0.7 H), 6.73 (d, 1 H), 6.59 (s, 0.7 H), 6.36 (s, 0.3 H), 6.09 (br s, 0.3 H), 3.74-3.94 (m, 1.5 H), 3.41-3.54 (m, 0.5 H), 2.74-3.03 (m, 2 H), 2.60-2.71 (m, 3 H) 417.1 [M+H] + 99.8%
1148 (CD 3OD) δ 8.26 (s, 1 H), 7.67 (s, 1 H), 7.47 (br d, 1 H), 7.12 (dd, 1 H), 6.90 (br s, 0.6 H), 6.71 (d, 1 H), 6.60 (br s, 1.4 H), 4.64-4.73 (m, 0.5 H), 4.18-4.42 (m, 0.5 H), 3.72-4.00 (m, 0.6 H), 3.37-3.56 (m, 0.4 H), 2.90-3.12 (m, 1 H), 2.82 (br d, 1 H), 2.67 (s, 3 H), 2.38 (s, 3 H) 363.2 [M+H] + 100%
1149 (CD 3OD) δ 8.26 (s, 1 H), 7.67 (s, 1 H), 7.47 (br d, 1 H), 7.12 (dd, 1 H), 6.89 (br s, 0.6 H), 6.71 (d, 1 H), 6.59 (br s, 1.4 H), 4.70-4.86 (m, 0.4 H), 4.32 (br s, 0.6 H), 3.86 (br s, 0.6 H), 3.37-3.55 (m, 0.4 H), 3.02 (br s, 1 H), 2.80 (dd, 1 H), 2.66 (s, 3 H), 2.38 (s, 3 H) 363.2 [M+H] + 100%
1150 (CD 3OD) δ 7.58-7.84 (m, 1 H), 7.40-7.54 (m, 1 H), 7.07-7.19 (m, 1 H), 6.92 (s, 0.6 H), 6.73 (d, 1 H), 6.60 (s, 0.6 H), 6.40 (s, 0.4 H), 6.14 (br s, 0.4 H), 3.73-3.96 (m, 1.5 H), 3.40-3.56 (m, 0.5 H), 2.92-3.07 (m, 1 H), 2.75-2.91 (m, 1 H), 2.60-2.72 (m, 3 H), 1.59-1.69 (m, 6 H) 475.2 [M+H] + 99.3%
1151 (CD 3OD) δ 7.62-7.77 (m, 1 H), 7.42-7.55 (m, 1 H), 7.08-7.21 (m, 1 H), 6.92 (s, 0.6 H), 6.73 (d, 1 H), 6.60 (s, 0.6 H), 6.40 (s, 0.4 H), 6.14 (s, 0.4 H), 3.77-3.95 (m, 1.4 H), 3.49 (td, 0.6 H), 2.92-3.07 (m, 1 H), 2.75-2.90 (m, 1 H), 2.64-2.73 (m, 3 H), 1.61-1.69 (m, 6 H) 475.2 [M+H] + 99.2%
1152 (CD 3OD) δ 7.55 (s, 1 H), 7.36 (br d, 1 H), 6.95-7.17 (m, 2 H), 6.30-6.91 (m, 3 H), 4.84-4.90 (m, 1 H), 4.53-4.67 (m, 0.5 H), 4.17-4.32 (m, 0.5 H), 3.66-3.86 (m, 0.5 H), 3.27-3.42 (m, 0.5 H), 2.64-3.06 (m, 2 H), 2.44-2.63 (m, 3 H), 1.32-1.65 (m, 3 H) 443.2 [M+H] + 99.5%
1153 (CD 3OD) δ 7.55 (s, 1 H), 7.36 (br d, 1 H), 6.92-7.20 (m, 2 H), 6.33-6.88 (m, 3 H), 4.87 (q, 1 H), 4.50-4.67 (m, 0.5 H), 4.15-4.33 (m, 0.5 H), 3.66-3.85 (m, 0.5 H), 3.26-3.47 (m, 0.5 H), 2.64-3.09 (m, 2 H), 2.55 (br s, 3 H), 1.49 (br s, 3 H) 443.2 [M+H] + 98.8%
1154 (CD 3OD) δ 8.32 (s, 1 H), 7.48-7.81 (m, 2 H), 7.22-7.34 (m, 1 H), 6.48-7.20 (m, 4 H), 4.20 (br s, 1 H), 3.79 (br d, 1 H), 2.91 (br s, 1 H), 2.70 (dd, 1 H) 453.1 [M+H] + 99.4%
1155 (CD 3OD) δ 8.32 (s, 1 H), 7.54-7.85 (m, 2 H), 7.20-7.34 (m, 1 H), 6.47-7.19 (m, 4 H), 4.21 (br s, 1 H), 3.78 (br s, 1 H), 2.92 (br d, 1 H), 2.70 (dd, 1 H) 453.1 [M+H] + 97.8%
1156 (CD 3OD) δ 7.87 (br s, 1 H), 7.69 (s, 1 H), 7.35-7.41 (m, 1 H), 6.68-7.32 (m, 4 H), 4.36 (br d, 1 H), 3.92 (br s, 1 H), 2.92-3.15 (m, 1 H), 2.83 (br d, 1 H), 1.53-1.76 (m, 6 H) 511.2 [M+H] + 99.8%
1157 (CD 3OD) δ 7.87 (br s, 1 H), 7.69 (s, 1 H), 7.33-7.45 (m, 1 H), 6.61-7.33 (m, 4 H), 4.37 (br d, 1 H), 3.91 (br s, 1 H), 2.93-3.13 (m, 1 H), 2.83 (br d, 1 H), 1.52-1.76 (m, 6 H) 511.2 [M+H] + 96.9%
1158 (CD 3OD) δ 8.68 (br s, 1 H), 8.39 (s, 1 H), 7.74-8.09 (m, 1 H), 7.69 (s, 1 H), 7.62 (br d, 1 H), 6.63-7.03 (m, 3 H), 4.73-4.87 (m, 1 H), 4.51 (br s, 0.4 H), 3.75 (br s, 0.6 H), 3.09 (br s, 1 H), 2.82 (br d, 1 H) 403.1 [M+H] + 99.6%
1159 (CD 3OD) δ 8.68 (br s, 1 H), 8.39 (s, 1 H), 7.73-8.09 (m, 1 H), 7.69 (s, 1 H), 7.62 (br d, 1 H), 6.63-7.03 (m, 3 H), 4.73-4.87 (m, 1 H), 4.51 (br s, 0.4 H), 3.74 (br s, 0.6 H), 3.09 (br s, 1 H), 2.82 (br d, 1 H) 403.1 [M+H] + 99.7%
1160 (CD 3OD) δ 7.87 (dd, 1 H), 7.59-7.77 (m, 1 H), 7.53 (br s, 0.5 H), 7.24-7.43 (m, 2 H), 6.87 (s, 1 H), 6.67 (s, 0.5 H), 4.95-5.02 (m, 1 H), 3.96 (br s, 0.5 H), 2.73-3.31 (m, 2.5 H), 1.82-1.99 (m, 6 H) 464.2 [M+H] + 99.1%
1161 (CD 3OD) δ 7.74 (dd, 1 H), 7.50-7.65 (m, 1 H), 7.41 (s, 0.5 H), 7.08-7.27 (m, 2 H), 6.67-6.89 (m, 1 H), 6.55 (s, 0.5 H), 4.84-4.89 (m, 1 H), 3.75-3.91 (m, 0.5 H), 2.70-3.19 (m, 2.5 H), 1.72-1.86 (m, 6 H) 464.2 [M+H] + 98.0%
1162 (CD 3OD) δ 7.68-7.80 (m, 1 H), 7.60 (d, 1 H), 7.26 (br d, 1 H), 7.13-7.20 (m, 1 H), 7.01 (s, 0.5 H), 6.72-6.88 (m, 1 H), 6.44 (s, 0.5 H), 4.84 (br s, 0.5 H), 4.24 (dd, 0.5 H), 3.89 (d, 3 H), 3.56-3.73 (m, 0.5 H), 2.92-3.15 (m, 1 H), 2.79-2.92 (m, 0.5 H), 2.59-2.77 (m, 1 H) 451.1 [M+H] + 98.4%
1163 (CD 3OD) δ 7.81-7.91 (m, 1 H), 7.72 (d, 1 H), 7.34-7.43 (m, 1 H), 7.23-7.33 (m, 1 H), 7.13 (s, 0.5 H), 6.84-6.96 (m, 1 H), 6.57 (s, 0.5 H), 4.95 (br d, 0.5 H), 4.36 (dd, 0.5 H), 4.01 (d, 3 H), 3.70-3.81 (m, 0.5 H), 3.07-3.27 (m, 1 H), 2.91-3.03 (m, 0.5 H), 2.71-2.90 (m, 1 H) 451.1 [M+H] + 99.1%
1164 (CD 3OD) δ 7.68 (s, 1 H), 7.47 (br s, 1 H), 6.97-7.28 (m, 2 H), 6.90 (br s, 0.4 H), 6.73 (br d, 1.3 H), 6.42-6.65 (m, 1.3 H), 4.96-5.01 (m, 1.8 H), 4.37 (br s, 0.2 H), 3.89 (br s, 0.5 H), 3.36-3.53 (m, 0.5 H), 2.90-3.12 (m, 1 H), 2.76-2.88 (m, 1 H), 2.68 (br s, 3 H), 1.62 (br s, 3 H) 443.1 [M+H] + 98.9%
1165 (CD 3OD) δ 7.70 (s, 1 H), 7.48 (br s, 1 H), 6.95-7.30 (m, 2 H), 6.90 (br s, 0.5 H), 6.73 (br d, 1.3 H), 6.43-6.66 (m, 1.2 H), 4.96-5.00 (m, 1.7 H), 4.38 (br s, 0.3 H), 3.88 (br s, 0.5 H), 3.50 (s, 0.5 H), 2.90-3.18 (m, 1 H), 2.83 (dd, 1 H), 2.68 (br s, 3 H), 1.61 (br s, 3 H) 443.2 [M+H] + 98.3%
1166 (CD 3OD) δ 8.29 (s, 1 H), 7.98 (br s, 1.5 H), 7.66 (br s, 0.5 H), 7.56 (s, 1 H), 6.58-6.85 (m, 2 H), 6.33-6.57 (m, 2 H), 4.37 (br s, 1 H), 3.85 (s, 3 H), 3.64 (br d, 1 H), 2.96 (br s, 1 H), 2.59-2.78 (m, 1 H) 365.2 [M+H] + 100%
1167 (CD 3OD) δ 8.29 (s, 1 H), 7.98 (br s, 1.5 H), 7.67 (br s, 0.5 H), 7.56 (s, 1 H), 6.57-6.82 (m, 2 H), 6.34-6.58 (m, 2 H), 4.36 (br s, 1 H), 3.85 (s, 3 H), 3.64 (br d, 1 H), 2.79-3.07 (m, 1 H), 2.59-2.79 (m, 1 H) 365.1 [M+H] + 99.2%
1168 (CD 3OD) δ 7.98-8.17 (m, 1 H), 7.69 (s, 1 H), 6.87-7.49 (m, 1 H), 6.74-6.84 (m, 1 H), 6.65 (s, 1 H), 6.56-6.62 (m, 1 H), 4.98 (br dd, 1 H), 3.92-4.00 (m, 3 H), 3.36-3.79 (m, 1 H), 2.77-3.21 (m, 2 H), 2.28-2.38 (m, 1 H), 1.20-1.33 (m, 4 H) 406.2 [M+H] + 98.8%
1169 (CD 3OD) δ 7.87-8.04 (m, 1 H), 7.57 (s, 1 H), 6.74-7.41 (m, 1 H), 6.65-6.71 (m, 1 H), 6.40-6.59 (m, 2 H), 4.86 (br dd, 1 H), 3.79-3.91 (m, 3 H), 3.24-3.66 (m, 1 H), 2.59-3.05 (m, 2 H), 2.08-2.33 (m, 1 H), 1.07-1.21 (m, 4 H) 406.2 [M+H] + 94.4%
1170 (CD 3OD) δ 8.17-8.28 (m, 1 H), 7.68 (s, 1 H), 7.45-7.53 (m, 1 H), 7.40 (s, 0.3 H), 7.05-7.12 (m, 1 H), 6.92 (s, 0.7 H), 6.43-6.58 (m, 1 H), 4.94 (br d, 1 H), 3.69-3.80 (m, 0.7 H), 3.34-3.43 (m, 0.3 H), 2.78-3.19 (m, 2 H), 2.28-2.35 (m, 3 H), 1.90-1.94 (m, 3 H), 1.84-1.88 (m, 3 H) 410.2 [M+H] + 100%
1171 (CD 3OD) δ 8.18-8.28 (m, 1 H), 7.68 (s, 1 H), 7.45-7.53 (m, 1 H), 7.40 (br s, 0.3 H), 7.04-7.13 (m, 1 H), 6.91 (br s, 0.7 H), 6.43-6.57 (m, 1 H), 4.93-4.96 (m, 1 H), 3.67-3.80 (m, 0.7 H), 3.34-3.44 (m, 0.3 H), 2.78-3.19 (m, 2 H), 2.27-2.37 (m, 3 H), 1.91 (d, 3 H), 1.86 (d, 3 H) 410.2 [M+H] + 98.5%
1172 (CD 3OD) δ 8.43-8.54 (m, 1 H), 7.56-7.69 (m, 2 H), 7.20 (br dd, 1 H), 7.06 (d, 1 H), 6.05-6.94 (m, 2 H), 3.45-3.99 (m, 2 H), 2.78-3.00 (m, 2 H) 437.1 [M+H] + 100%
1173 (CD 3OD) δ 8.40-8.51 (m, 1 H), 7.54-7.68 (m, 2 H), 7.14-7.23 (m, 1 H), 7.03 (d, 1 H), 6.05-6.94 (m, 2 H), 3.42-3.94 (m, 2 H), 2.76-2.99 (m, 2 H) 437.1 [M+H] + 100%
1174 (CD 3OD) δ 8.26 (s, 1 H), 7.67 (s, 1 H), 7.61 (br d, 1 H), 7.18 (dd, 1 H), 7.04 (dd, 1 H), 6.49-6.94 (m, 2 H), 4.25-4.44 (m, 1 H), 3.85 (td, 1 H), 2.76-3.07 (m, 2 H), 2.39 (s, 3 H) 383.1 [M+H] + 100%
1175 (CD 3OD) δ 8.26 (s, 1 H), 7.68 (br s, 1 H), 7.61 (br d, 1 H), 7.18 (t, 1 H), 7.00-7.05 (m, 1 H), 6.57-6.91 (m, 2 H), 4.35 (br s, 1 H), 3.74-3.97 (m, 1 H), 2.78-3.07 (m, 2 H), 2.39 (s, 3 H) 383.1 [M+H] + 99.7%
1176 (CD 3OD) δ 8.35 (s, 1 H), 7.56-7.83 (m, 2 H), 7.12-7.29 (m, 2 H), 6.70-6.84 (m, 1.4 H), 6.47 (s, 0.3 H), 6.03 (s, 0.3 H), 3.60-3.88 (m, 1.6 H), 3.37 (td, 0.4 H), 2.61-2.91 (m, 2 H) 471.1 [M+H] + 99.1%
1177 (CD 3OD) δ 8.48 (s, 1 H), 7.75-8.01 (m, 1 H), 7.64-7.73 (m, 1 H), 7.24-7.43 (m, 2 H), 6.80-6.95 (m, 1.4 H), 6.59 (s, 0.3 H), 6.14 (s, 0.3 H), 3.78-4.01 (m, 1.5 H), 3.42-3.55 (m, 0.5 H), 2.75-3.02 (m, 2 H) 471.1 [M+H] + 98.6%
1178 (CD 3OD) δ 7.80-7.95 (m, 1 H), 7.61-7.77 (m, 1 H), 7.23-7.48 (m, 2 H), 6.80-7.00 (m, 1.3 H), 6.66 (s, 0.3 H), 5.91-6.40 (m, 0.4 H), 4.96-5.00 (m, 0.2 H), 3.75-4.10 (m, 1.4 H), 3.51 (br d, 0.4 H), 2.90-3.08 (m, 1 H), 2.82 (br t, 1 H), 1.57-1.70 (m, 6 H) 529.2 [M+H] + 96.3%
1179 (CD 3OD) δ 7.81-7.93 (m, 1 H), 7.54-7.78 (m, 1 H), 7.13-7.46 (m, 2 H), 6.79-7.06 (m, 1.3 H), 6.66 (s, 0.4 H), 6.21 (br s, 0.3 H), 4.93-4.98 (m, 0.2 H), 3.77-4.00 (m, 1.4 H), 3.52 (td, 0.4 H), 2.75-3.08 (m, 2 H), 1.55-1.73 (m, 6 H) 529.2 [M+H] + 97.8%
1180 (CD 3OD) δ 7.88 (br d, 1 H), 7.68 (s, 1 H), 7.34-7.40 (m, 1 H), 7.25-7.33 (m, 1 H), 6.92-7.25 (m, 1 H), 6.68-6.91 (m, 2 H), 4.98 (br s, 1.5 H), 4.25-4.48 (m, 0.5 H), 3.78-4.02 (m, 0.5 H), 3.35-3.50 (m, 0.5 H), 2.90-3.22 (m, 1 H), 2.83 (br d, 1 H), 1.46-1.75 (m, 3 H) 497.2 [M+H] + 96.9%
1181 (CD 3OD) δ 7.87 (br d, 1 H), 7.68 (s, 1 H), 7.36 (d, 1 H), 7.25-7.33 (m, 1 H), 6.92-7.24 (m, 1 H), 6.69-6.91 (m, 2 H), 4.98 (br s, 1.5 H), 4.26-4.47 (m, 0.5 H), 3.78-4.02 (m, 0.5 H), 3.36-3.49 (m, 0.5 H), 2.90-3.20 (m, 1 H), 2.83 (br d, 1 H), 1.44-1.76 (m, 3 H) 497.2 [M+H] + 95.5%
1182 (CD 3OD) δ 7.85-8.07 (m, 1 H), 7.46-7.65 (m, 1 H), 7.28 (s, 0.3 H), 6.81 (s, 0.7 H), 6.63-6.72 (m, 1 H), 6.39-6.58 (m, 2 H), 4.85 (br d, 1 H), 3.80-3.89 (m, 3 H), 3.24-3.69 (m, 1 H), 2.65-3.10 (m, 2 H), 1.37 (s, 9 H) 422.2 [M+H] + 100%
1183 (CD 3OD) δ 7.87-8.06 (m, 1 H), 7.58 (br s, 1 H), 7.28 (br s, 0.3 H), 6.81 (br s, 0.6 H), 6.63-6.72 (m, 1 H), 6.35-6.58 (m, 2 H), 4.81-4.93 (m, 1 H), 3.78-3.90 (m, 3 H), 3.24-3.70 (m, 1 H), 2.64-3.09 (m, 2 H), 1.37 (s, 9 H) 422.2 [M+H] + 99.7%
1184 (CD 3OD) δ 8.23-8.42 (m, 2 H), 7.70-8.14 (m, 1 H), 7.66 (s, 1 H), 7.34 (s, 1 H), 6.25-6.92 (m, 3 H), 4.75 (br s, 0.5 H), 4.46 (br s, 0.5 H), 3.74 (br s, 0.5 H), 3.35 (br s, 0.5 H), 2.66-3.19 (m, 2 H), 2.36 (s, 3 H) 349.2 [M+H] + 99.5%
1185 (CD 3OD) δ 8.25-8.44 (m, 2 H), 7.71-8.13 (m, 1 H), 7.67 (s, 1 H), 7.33 (s, 1 H), 6.28-6.93 (m, 3 H), 4.76 (br s, 0.5 H), 4.46 (br s, 0.5 H), 3.74 (br s, 0.5 H), 3.35 (br s, 0.5 H), 2.67-3.19 (m, 2 H), 2.36 (s, 3 H) 349.2 [M+H] + 98.4%
1186 (CD 3OD) δ 8.15-8.42 (m, 2 H), 7.66 – 8.10 (m, 2 H), 7.49 (d, 1 H), 7.08 (d, 1 H), 6.29-6.96 (m, 2 H), 4.69-4.85 (m, 1 H), 4.46 (br s, 0.5 H), 3.62-3.85 (m, 0.5 H), 2.73-3.13 (m, 2 H), 2.32 (s, 3 H) 349.1 [M+H] + 100%
1187 (CD 3OD) δ 8.11-8.41 (m, 2 H), 7.55-8.08 (m, 2 H), 7.49 (d, 1 H), 7.08 (d, 1 H), 6.29-6.96 (m, 2 H), 4.76 (br s, 1 H), 4.45 (br s, 0.5 H), 3.74 (br s, 0.5 H), 2.65-3.16 (m, 2 H), 2.32 (s, 3 H) 349.2 [M+H] + 99.4%
1188 (CD 3OD) δ 7.98 (br s, 1 H), 7.71 (d, 1 H), 7.40-7.50 (m, 1.5 H), 7.05-7.14 (m, 1 H), 6.98 (s, 0.5 H), 6.68 (br dd, 1 H), 6.61 (s, 0.6 H), 6.46 (s, 0.4 H), 5.03-5.12 (m, 0.6 H), 3.84-3.95 (m, 4 H), 3.33-3.42 (m, 0.4 H), 3.11-3.22 (m, 0.6 H), 2.93-3.03 (m, 0.4 H), 2.80-2.88 (m, 1 H), 2.64-2.68 (m, 5 H), 2.50 (s, 1 H) 444.2 [M+H] + 98.4%
1189 (CD 3OD) δ 7.98 (d, 1 H), 7.69 (d, 1 H), 7.40-7.50 (m, 1.5 H), 7.10 (dt, 1 H), 6.98 (s, 0.5 H), 6.69 (dd, 1 H), 6.61 (s, 0.6 H), 6.45 (s, 0.4 H), 5.08 (br dd, 0.6 H), 3.82-3.95 (m, 4 H), 3.34-3.41 (m, 0.4 H), 3.11-3.22 (m, 0.6 H), 2.93-3.04 (m, 0.4 H), 2.80-2.88 (m, 1 H), 2.64-2.68 (m, 5 H), 2.51 (s, 1 H) 444.2 [M+H] + 92.9%
1190 (CD 3OD) δ 7.99 (d, 1 H), 7.79-7.90 (m, 1 H), 7.73 (s, 0.5 H), 7.67 (s, 0.5 H), 7.58 (s, 0.5 H), 7.21-7.37 (m, 2 H), 6.96 (s, 0.5 H), 6.86 (s, 0.5 H), 6.66 (s, 0.5 H), 5.11 (br dd, 0.5 H), 4.93-4.99 (m, 1 H), 3.91-3.99 (m, 0.5 H), 3.89 (d, 3 H), 3.11-3.22 (m, 0.5 H), 2.93-3.04 (m, 0.5 H), 2.85 (br d, 1 H), 2.67 (s, 3 H) 498.2 [M+H] + 98.5%
1191 (CD 3OD) δ 7.99 (br d, 1 H), 7.79-7.90 (m, 1 H), 7.74 (br s, 0.5 H), 7.61-7.70 (m, 0.5 H), 7.59 (br s, 0.5 H), 7.22-7.37 (m, 2 H), 6.97 (br s, 0.5 H), 6.86 (s, 0.5 H), 6.66 (s, 0.5 H), 5.06-5.15 (m, 0.5 H), 4.96 (br d, 1 H), 3.92-4.00 (m, 0.5 H), 3.89 (br d, 3 H), 3.11-3.25 (m, 0.5 H), 2.92-3.05 (m, 0.5 H), 2.80-2.91 (m, 1 H), 2.67 (s, 3 H) 498.2 [M+H] + 95.2%
1192 (CD 3OD) δ 7.54-7.73 (m, 2 H), 7.20 (br t, 1 H), 7.06 (d, 1 H), 6.57-6.97 (m, 1.6 H), 6.14 (br s, 0.4 H), 3.78-4.03 (m, 1.5 H), 3.52 (td, 0.5 H), 2.72-3.08 (m, 2 H), 1.61-1.70 (m, 6 H) 495.2 [M+H] + 100%
1193 (CD 3OD) δ 7.45-7.59 (m, 2 H), 7.09 (br t, 1 H), 6.94 (d, 1 H), 6.42-6.85 (m, 1.6 H), 6.02 (br s, 0.4 H), 3.75 (br d, 1.5 H), 3.33-3.49 (m, 0.5 H), 2.64-2.94 (m, 2 H), 1.49-1.57 (m, 6 H) 495.1 [M+H] + 97.0%
1194 (CD 3OD) δ 7.57-7.71 (m, 2 H), 7.12-7.32 (m, 1.7 H), 6.98-7.10 (m, 1.3 H), 6.54-6.95 (m, 2 H), 4.96-5.02 (m, 1 H), 4.77-4.86 (m, 0.5 H), 4.40 (br d, 0.5 H), 3.88 (br s, 0.5 H), 3.38-3.54 (m, 0.5 H), 2.76-3.20 (m, 2 H), 1.49-1.72 (m, 3 H) 463.1 [M+H] + 100%
1195 (CD 3OD) δ 7.54-7.69 (m, 2 H), 7.10-7.30 (m, 1.8 H), 6.97-7.08 (m, 1.2 H), 6.58-6.96 (m, 2 H), 4.97 (br d, 1 H), 4.77-4.85 (m, 0.5 H), 4.38 (br d, 0.5 H), 3.86 (br s, 0.5 H), 3.45 (br d, 0.5 H), 2.74-3.18 (m, 2 H), 1.60 (br s, 3 H) 463.1 [M+H] + 91.7%
1196 (CD 3OD) δ 7.68 (s, 1 H), 7.62 (br d, 1 H), 7.14-7.31 (m, 2 H), 7.00-7.08 (m, 1 H), 6.61-6.92 (m, 2 H), 4.99 (br d, 1 H), 4.64-4.68 (m, 1 H), 4.34-4.44 (m, 0.5 H), 3.81-3.93 (m, 0.5 H), 2.80-3.14 (m, 2 H), 1.55-1.66 (m, 3 H) 463.1 [M+H] + 97.3%
1197 (CD 3OD) δ 7.68 (s, 1 H), 7.62 (br d, 1 H), 7.14-7.29 (m, 2 H), 7.01-7.07 (m, 1 H), 6.64-6.92 (m, 2 H), 4.99 (br d, 1 H), 4.64-4.67 (m, 1 H), 4.40 (br dd, 0.5 H), 3.88 (br s, 0.5 H), 2.81-3.17 (m, 2 H), 1.62 (br s, 3 H) 463.1 [M+H] + 98.7%
1198 (CD 3OD) δ 8.26 (s, 1 H), 7.86 (br d, 1 H), 7.68 (s, 1 H), 7.24-7.41 (m, 2 H), 6.86 (br s, 2 H), 4.33 (br s, 0.9 H), 3.55-4.05 (m, 1.1 H), 3.01 (br s, 1 H), 2.80 (dd, 1 H), 2.37 (s, 3 H) 417.1 [M+H] + 99.8%
1199 (CD 3OD) δ 8.14 (s, 1 H), 7.75 (br d, 1 H), 7.56 (s, 1 H), 7.08-7.31 (m, 2 H), 6.39-6.83 (m, 2 H), 4.22 (br s, 1 H), 3.51-3.90 (m, 1 H), 2.81-3.00 (m, 1 H), 2.68 (br dd, 1 H), 2.25 (s, 3 H) 417.1 [M+H] + 99.7%
1200 (CD 3OD) δ 7.75 (br d, 1 H), 7.57 (s, 1 H), 7.14-7.28 (m, 2 H), 6.55-7.12 (m, 3 H), 4.86 (br s, 1 H), 4.25 (br s, 1 H), 3.26-3.86 (m, 1 H), 2.82-3.03 (m, 1 H), 2.71 (dd, 1 H), 1.41-1.56 (m, 3 H) 497.2 [M+H] + 88.2%
1201 (CD 3OD) δ 7.87 (br d, 1 H), 7.68 (s, 1 H), 7.23-7.42 (m, 2 H), 6.60-7.23 (m, 3 H), 4.98 (br s, 1 H), 4.36 (br s, 1 H), 3.41-4.06 (m, 1 H), 2.94-3.17 (m, 1 H), 2.83 (br d, 1 H), 1.43-1.73 (m, 3 H) 497.1 [M+H] + 98.7%
1202 (CD 3OD) δ 8.44 (s, 1 H), 7.69 (s, 1 H), 7.48 (br d, 1 H), 7.00-7.33 (m, 2 H), 6.73-6.95 (m, 1.4 H), 6.48-6.72 (m, 1.6 H), 4.79-4.86 (m, 0.3 H), 4.36 (br d, 0.7 H), 3.71-3.97 (m, 0.7 H), 3.37-3.49 (m, 0.3 H), 3.08 (br s, 1 H), 2.82 (br d, 1 H) 403.1 [M+H] + 99.8%
1203 (CD 3OD) δ 8.44 (s, 1 H), 7.69 (s, 1 H), 7.48 (br d, 1 H), 6.99-7.33 (m, 2 H), 6.72-6.94 (m, 1.5 H), 6.51-6.71 (m, 1.5 H), 4.85 (br s, 0.3 H), 4.36 (br d, 0.7 H), 3.80 (br s, 0.7 H), 3.37-3.48 (m, 0.3 H), 3.09 (br s, 1 H), 2.82 (br d, 1 H) 403.2 [M+H] + 99.1%
1204 (CD 3OD) δ 8.59-8.76 (m, 1 H), 7.91-8.05 (m, 1 H), 7.70 (s, 1 H), 7.52-7.67 (m, 1.4 H), 6.91-7.05 (m, 1.6 H), 6.72-6.83 (m, 1 H), 4.94-5.15 (m, 1 H), 3.83-3.95 (m, 3 H), 3.68-3.82 (m, 0.7 H), 3.39 (td, 0.3 H), 2.79-3.25 (m, 2 H), 2.59-2.72 (m, 3 H) 498.2 [M+H] + 100%
1205 (CD 3OD) δ 8.57-8.79 (m, 1 H), 7.94-8.07 (m, 1 H), 7.70 (s, 1 H), 7.52-7.67 (m, 1.3 H), 6.90-7.06 (m, 1.7 H), 6.73-6.83 (m, 1 H), 5.12 (br dd, 1 H), 3.86-3.95 (m, 3 H), 3.69-3.83 (m, 0.7 H), 3.39 (td, 0.3 H), 2.78-3.25 (m, 2 H), 2.63-2.71 (m, 3 H) 498.2 [M+H] + 100%
1206 (CD 3OD) δ 7.93-8.15 (m, 2 H), 7.69 (s, 1 H), 7.53 (s, 0.3 H), 6.94 (s, 0.7 H), 6.73-6.85 (m, 1 H), 6.66 (s, 0.6 H), 6.53-6.63 (m, 1.4 H), 5.06 (dd, 1 H), 3.83-4.01 (m, 6 H), 3.70-3.79 (m, 0.7 H), 3.39 (td, 0.3 H), 2.77-3.24 (m, 2 H), 2.62-2.71 (m, 3 H) 460.2 [M+H] + 98.2%
1207 (CD 3OD) δ 7.95-8.16 (m, 2 H), 7.69 (s, 1 H), 7.53 (br s, 0.3 H), 6.93 (s, 0.7 H), 6.72-6.85 (m, 1 H), 6.66 (s, 0.7 H), 6.52-6.63 (m, 1.3 H), 5.06 (br dd, 1 H), 3.85-4.01 (m, 6 H), 3.70-3.82 (m, 0.7 H), 3.35-3.44 (m, 0.3 H), 2.79-3.23 (m, 2 H), 2.61-2.73 (m, 3 H) 460.2 [M+H] + 97.2%
1208 (CD 3OD) δ 7.98 (br s, 1 H), 7.65-7.72 (m, 1 H), 7.49-7.64 (m, 1.5 H), 7.11-7.21 (m, 1 H), 6.94-7.06 (m, 1.5 H), 6.78 (s, 0.5 H), 6.64 (s, 0.5 H), 5.11 (dd, 0.6 H), 4.95 (br d, 0.4 H), 3.93 (br d, 0.5 H), 3.88 (s, 3 H), 3.38 (td, 0.5 H), 3.12-3.23 (m, 0.6 H), 2.93-3.04 (m, 0.4 H), 2.85 (br dd, 1 H), 2.62-2.70 (m, 3 H) 464.2 [M+H] + 98.9%
1209 (CD 3OD) δ 7.95-8.03 (m, 1 H), 7.67-7.72 (m, 1 H), 7.50-7.65 (m, 1.5 H), 7.11-7.21 (m, 1 H), 6.94-7.08 (m, 1.5 H), 6.79 (d, 0.5 H), 6.64 (s, 0.5 H), 5.11 (dd, 0.6 H), 4.94-4.96 (m, 0.4 H), 3.92 (br d, 0.5 H), 3.89 (s, 3 H), 3.38 (td, 0.5 H), 3.11-3.24 (m, 0.6 H), 2.93-3.05 (m, 0.4 H), 2.85 (br dd, 1 H), 2.62-2.71 (m, 3 H) 464.2 [M+H] + 94.5%
1210 (CD 3OD) δ 7.55-7.76 (m, 2 H), 7.17 (dd, 1 H), 6.97-7.06 (m, 1 H), 6.49-6.94 (m, 2 H), 4.96-4.97 (m, 0.5 H), 4.36 (br s, 0.5 H), 3.85 (br s, 0.5 H), 3.38-3.44 (m, 0.5 H), 2.71-3.18 (m, 2 H), 2.36 (s, 3 H), 1.62 (br s, 6 H) 441.2 [M+H] + 98.9%
1211 (CD 3OD) δ 7.56-7.69 (m, 2 H), 7.14-7.26 (m, 1 H), 7.02 (d, 1 H), 6.42-6.98 (m, 2 H), 4.98-5.00 (m, 0.5 H), 4.35 (br s, 0.5 H), 3.85 (br s, 0.5 H), 3.38-3.48 (m, 0.5 H), 2.68-3.19 (m, 2 H), 2.36 (s, 3 H), 1.62 (br s, 6 H) 441.2 [M+H] + 97.8%
1212 (CD 3OD) δ 7.57-7.69 (m, 2 H), 7.17 (dd, 1 H), 7.02 (dd, 1 H), 6.50-6.94 (m, 2 H), 4.98-5.01 (m, 1.5 H), 4.36 (br s, 0.5 H), 3.84 (br s, 0.5 H), 3.37-3.43 (m, 0.5 H), 2.72-3.10 (m, 2 H), 2.36 (s, 3 H), 1.56 (br s, 3 H) 427.1 [M+H] + 98.6%
1213 (CD 3OD) δ 7.52-7.73 (m, 2 H), 7.09-7.24 (m, 1 H), 7.02 (d, 1 H), 6.47-6.90 (m, 2 H), 4.99-5.05 (m, 1.5 H), 4.37 (br s, 0.5 H), 3.84 (br s, 0.5 H), 3.38-3.47 (m, 0.5 H), 2.74-3.14 (m, 2 H), 2.36 (s, 3 H), 1.56 (br s, 3 H) 427.1 [M+H] + 99.5%
1214 (CD 3OD) δ 8.30-8.54 (m, 1 H), 7.91-8.07 (m, 1 H), 7.71 (s, 1 H), 7.56 (s, 0.3 H), 7.19-7.36 (m, 1 H), 6.95 (s, 0.6 H), 6.69-6.89 (m, 2 H), 5.10 (br dd, 1 H), 3.88 (s, 3 H), 3.72-3.80 (m, 0.6 H), 3.37-3.43 (m, 0.4 H), 2.78-3.24 (m, 2 H), 2.61-2.73 (m, 3 H) 464.1 [M+H] + 100%
1215 (CD 3OD) δ 8.31-8.50 (m, 1 H), 7.82-8.07 (m, 1 H), 7.70 (s, 1 H), 7.55 (s, 0.3 H), 7.30 (br t, 1 H), 6.95 (s, 0.7 H), 6.67-6.88 (m, 2 H), 5.10 (br dd, 1 H), 3.89 (s, 3 H), 3.72-3.80 (m, 0.5 H), 3.39-3.44 (m, 0.5 H), 2.82-3.23 (m, 2 H), 2.57-2.73 (m, 3 H) 464.2 [M+H] + 99.4%
1216 (CD 3OD) δ 8.30 (br d, 1 H), 7.68 (s, 1 H), 7.28 (s, 0.4 H), 7.15 (s, 0.6 H), 6.96-7.03 (m, 1 H), 6.73-6.90 (m, 2 H), 6.52-6.64 (m, 1 H), 4.29 (br d, 1 H), 3.75 (br t, 0.6 H), 3.36-3.47 (m, 0.4 H), 2.77-3.14 (m, 2 H), 2.44 (br s, 3 H), 1.72-1.91 (m, 6 H) 459.2 [M+H] + 99.7%
1217 (CD 3OD) δ 8.29 (br d, 1 H), 7.68 (br s, 1 H), 7.28 (s, 0.4 H), 7.15 (s, 0.6 H), 6.96-7.03 (m, 1 H), 6.71-6.89 (m, 2 H), 6.52-6.65 (m, 1 H), 4.29 (br d, 1 H), 3.75 (br t, 0.6 H), 3.37-3.50 (m, 0.4 H), 2.74-3.15 (m, 2 H), 2.44 (br s, 3 H), 1.68-1.93 (m, 6 H) 459.2 [M+H] + 98.6%
1218 (CD 3OD) δ 8.69 (d, 1 H), 7.61-7.71 (m, 2 H), 7.27 (s, 0.5 H), 7.14 (s, 0.5 H), 6.96-7.02 (m, 1 H), 6.76-6.90 (m, 1.5 H), 6.57 (br d, 0.5 H), 4.28-4.37 (m, 0.8 H), 3.69-3.80 (m, 1 H), 3.41-3.51 (m, 0.2 H), 2.79-3.15 (m, 2 H), 1.69-1.91 (m, 6 H) 513.2 [M+H] + 98.8%
1219 (CD 3OD) δ 8.69 (d, 1 H), 7.60-7.75 (m, 2 H), 7.27 (s, 0.5 H), 7.14 (s, 0.5 H), 6.96-7.02 (m, 1 H), 6.76-6.89 (m, 1.5 H), 6.57 (br s, 0.5 H), 4.25-4.40 (m, 1 H), 3.67-3.83 (m, 0.8 H), 3.40-3.51 (m, 0.2 H), 2.77-3.15 (m, 2 H), 1.67-1.93 (m, 6 H) 513.2 [M+H] + 98.5%
1220 (CD 3OD) δ 8.32 (d, 1 H), 7.69 (s, 1 H), 6.99-7.33 (m, 2 H), 6.43-6.90 (m, 3 H), 4.35-4.46 (m, 1 H), 3.45-3.79 (m, 1 H), 2.81-3.13 (m, 2 H), 2.46 (s, 3 H), 1.28-1.43 (m, 4 H) 455.2 [M+H] + 99.8%
1221 (CD 3OD) δ 8.32 (d, 1 H), 7.69 (s, 1 H), 6.99-7.28 (m, 2 H), 6.55-6.89 (m, 3 H), 4.34-4.47 (m, 1 H), 3.65-3.81 (m, 1 H), 2.80-3.11 (m, 2 H), 2.46 (s, 3 H), 1.26-1.42 (m, 4 H) 455.2 [M+H] + 98.5%
1222 (CD 3OD) δ 8.71 (d, 1 H), 7.62-7.74 (m, 2 H), 6.98-7.28 (m, 2 H), 6.54-6.90 (m, 2 H), 4.44 (br d, 1 H), 3.74 (br s, 1 H), 2.81-3.17 (m, 2 H), 1.21-1.46 (m, 4 H) 509.1 [M+H] + 99.4%
1223 (CD 3OD) δ 8.71 (br d, 1 H), 7.60-7.76 (m, 2 H), 6.96-7.30 (m, 2 H), 6.53-6.92 (m, 2 H), 4.35-4.57 (m, 1 H), 3.76 (br d, 1 H), 2.81-3.16 (m, 2 H), 1.22-1.46 (m, 4 H) 509.2 [M+H] + 99.6%
1224 (CD 3OD) δ 8.41 (s, 1 H), 8.07-8.19 (m, 1 H), 7.71 (s, 1 H), 7.60 (s, 0.3 H), 7.42-7.53 (m, 1 H), 7.19-7.33 (m, 1 H), 6.98 (s, 0.7 H), 6.80 (d, 0.7 H), 6.58-6.73 (m, 1.3 H), 5.12 (dd, 1 H), 4.02 (s, 3 H), 3.73-3.91 (m, 0.7 H), 3.43 (td, 0.3 H), 3.13-3.25 (m, 0.7 H), 2.95-3.07 (m, 0.3 H), 2.80-2.90 (m, 1 H) 434.2 [M+H] + 100%
1225 (CD 3OD) δ 8.42 (s, 1 H), 8.09-8.18 (m, 1 H), 7.77 (s, 1 H), 7.61 (s, 0.3 H), 7.41-7.54 (m, 1 H), 7.20-7.36 (m, 1 H), 6.99 (s, 0.7 H), 6.70-6.87 (m, 1 H), 6.62-6.70 (m, 1 H), 5.13 (br dd, 1 H), 4.02 (s, 3 H), 3.75-3.91 (m, 0.7 H), 3.43 (td, 0.3 H), 3.13-3.26 (m, 0.7 H), 2.94-3.07 (m, 0.3 H), 2.87 (br dd, 1 H) 434.2 [M+H] + 97.8%
1226 (CD 3OD) δ 8.33 (d, 1 H), 7.68 (s, 1 H), 7.27 (s, 0.5 H), 7.14 (s, 0.5 H), 6.93-7.01 (m, 1 H), 6.68-6.85 (m, 2.5 H), 6.56 (br s, 0.5 H), 4.31 (br d, 1 H), 3.75 (br t, 0.6 H), 3.40 (br s, 0.4 H), 2.74-3.15 (m, 2 H), 1.68-1.90 (m, 6 H) 463.2 [M+H] + 99.1%
1227 (CD 3OD) δ 8.30-8.36 (m, 1 H), 7.70 (br s, 1 H), 7.27 (s, 0.5 H), 7.14 (s, 0.5 H), 6.91-7.02 (m, 1 H), 6.68-6.87 (m, 2.5 H), 6.57 (br s, 0.5 H), 4.31 (br dd, 1 H), 3.75 (br t, 0.6 H), 3.34-3.46 (m, 0.4 H), 2.74-3.16 (m, 2 H), 1.69-1.92 (m, 6 H) 463.1 [M+H] + 99.6%
1228 (CD 3OD) δ 8.45 (br d, 1 H), 7.69 (s, 1 H), 7.01-7.33 (m, 2 H), 6.70-6.89 (m, 2.5 H), 6.56 (br s, 0.5 H), 4.32 (br d, 1 H), 3.70-3.80 (m, 0.6 H), 3.38-3.50 (m, 0.4 H), 2.75-3.16 (m, 2 H), 1.72-1.91 (m, 6 H) 479.1 [M+H] + 99.6%
1229 (CD 3OD) δ 8.38-8.44 (m, 1 H), 7.68 (br s, 1 H), 6.99-7.30 (m, 2 H), 6.70-6.88 (m, 2.5 H), 6.55 (br s, 0.5 H), 4.26-4.37 (m, 1 H), 3.74 (br t, 0.6 H), 3.41 (br s, 0.4 H), 2.75-3.15 (m, 2 H), 1.69-1.89 (m, 6 H) 479.1 [M+H] + 98.9%
1230 (CD 3OD) δ 7.68 (s, 1 H), 7.47 (br s, 1 H), 6.97-7.31 (m, 2 H), 6.37-6.95 (m, 3 H), 4.65-4.75 (m, 0.4 H), 4.22-4.41 (m, 0.6 H), 3.45-3.97 (m, 1 H), 2.80-3.12 (m, 2 H), 2.65 (br d, 3 H), 1.65-2.03 (m, 6 H) 459.2 [M+H] + 99.1%
1231 (CD 3OD) δ 7.56 (s, 1 H), 7.35 (br d, 1 H), 6.85-7.20 (m, 2 H), 6.21-6.83 (m, 3 H), 4.54-4.64 (m, 0.4 H), 4.19 (br d, 0.6 H), 3.36-3.83 (m, 1 H), 2.67-3.01 (m, 2 H), 2.40-2.66 (m, 3 H), 1.48-2.07 (m, 6 H) 459.2 [M+H] + 96.3%
1232 (CD 3OD) δ 7.70 (s, 1 H), 7.61 (br s, 1 H), 7.10-7.44 (m, 2 H), 7.00-7.09 (m, 1 H), 6.61-6.93 (m, 2 H), 4.71-4.84 (m, 0.5 H), 4.23-4.45 (m, 0.5 H), 3.37-4.01 (m, 1 H), 2.73-3.21 (m, 2 H), 1.70-1.97 (m, 6 H) 479.2 [M+H] + 99.8%
1233 (CD 3OD) δ 7.69 (s, 1 H), 7.62 (br s, 1 H), 7.07-7.43 (m, 2 H), 7.02-7.07 (m, 1 H), 6.57-6.96 (m, 2 H), 4.75-4.88 (m, 0.5 H), 4.25-4.44 (m, 0.5 H), 3.38-3.99 (m, 1 H), 2.72-3.21 (m, 2 H), 1.72-1.96 (m, 6 H) 479.1 [M+H] + 99.4%
1234 (CD 3OD) δ 8.36 (d, 1 H), 7.70 (s, 1 H), 7.07-7.28 (m, 1 H), 6.96-7.01 (m, 1 H), 6.56-6.89 (m, 3 H), 4.29-4.55 (m, 1 H), 3.54-3.87 (m, 1 H), 2.80-3.14 (m, 2 H), 1.26-1.43 (m, 4 H) 459.2 [M+H] + 99.1%
1235 (CD 3OD) δ 8.36 (d, 1 H), 7.70 (s, 1 H), 7.09-7.32 (m, 1 H), 6.96-7.01 (m, 1 H), 6.58-6.90 (m, 3 H), 4.33-4.55 (m, 1 H), 3.51-3.84 (m, 1 H), 2.82-3.16 (m, 2 H), 1.26-1.43 (m, 4 H) 459.1 [M+H] + 93.9%
1236 (CD 3OD) δ 7.55-7.74 (m, 2 H), 7.00-7.28 (m, 3 H), 6.52-6.93 (m, 2 H), 5.02-5.17 (m, 0.2 H), 4.28-4.55 (m, 0.8 H), 3.52-4.00 (m, 1 H), 2.79-3.16 (m, 2 H), 1.26-1.46 (m, 4 H) 475.1 [M+H] + 99.6%
1237 (CD 3OD) δ 7.57-7.73 (m, 2 H), 6.99-7.29 (m, 3 H), 6.65-6.95 (m, 2 H), 4.99-5.12 (m, 0.2 H), 4.36-4.55 (m, 0.8 H), 3.51-4.01 (m, 1 H), 2.80-3.10 (m, 2 H), 1.26-1.43 (m, 4 H) 475.1 [M+H] + 98.0%
1238 (CD 3OD) δ 7.69 (s, 1 H), 7.48 (br d, 1 H), 6.96-7.33 (m, 2 H), 6.71-6.93 (m, 1.7 H), 6.66 (t, 1.3 H), 4.79-4.84 (m, 0.4 H), 4.38 (br d, 0.6 H), 3.81 (br s, 0.6 H), 3.45 (br s, 0.4 H), 2.95-3.23 (m, 1 H), 2.86 (br s, 1 H), 1.52-1.71 (m, 6 H) 461.2 [M+H] + 95.1%
1239 (CD 3OD) δ 7.73 (br s, 1 H), 7.49 (br d, 1 H), 6.97-7.34 (m, 2 H), 6.72-6.93 (m, 1.7 H), 6.58-6.71 (m, 1.3 H), 4.74-4.82 (m, 0.5 H), 4.39 (br d, 0.5 H), 3.80 (br s, 0.5 H), 3.37-3.49 (m, 0.5 H), 2.93-3.22 (m, 1 H), 2.85 (br d, 1 H), 1.59-1.71 (m, 6 H) 461.2 [M+H] + 97.3%
1240 (CD 3OD) δ 8.43 (s, 1 H), 7.68 (s, 1 H), 7.21 (br d, 3 H), 6.90 (br s, 0.7 H), 6.40-6.71 (m, 1.3 H), 6.23-6.38 (m, 1 H), 4.42 (q, 2.8 H), 3.82 (br s, 1.2 H), 3.07 (br s, 1 H), 2.82 (br d, 1 H), 1.57 (t, 3 H) 429.2 [M+H] + 99.6%
1241 (CD 3OD) δ 8.43 (s, 1 H), 7.68 (s, 1 H), 7.21 (br d, 3 H), 6.90 (br s, 0.6 H), 6.61 (br s, 1.4 H), 6.26-6.37 (m, 1 H), 4.42 (q, 2.7 H), 3.82 (br s, 1.3 H), 3.07 (br s, 1 H), 2.81 (br d, 1 H), 1.57 (t, 3 H) 429.1 [M+H] + 98.3%
1242 (CD 3OD) δ 7.59-7.85 (m, 1 H), 6.89-7.55 (m, 3 H), 6.23-6.72 (m, 2 H), 4.33-4.51 (m, 2 H), 3.38-3.89 (m, 2 H), 2.78-3.25 (m, 2 H), 1.79-2.03 (m, 6 H), 1.46-1.65 (m, 3 H) 440.2 [M+H] + 99.7%
1243 (CD 3OD) δ 7.57 (s, 1 H), 6.78-7.47 (m, 3 H), 6.05-6.57 (m, 2 H), 4.22-4.37 (m, 2 H), 3.24-3.77 (m, 2 H), 2.67-3.10 (m, 2 H), 1.62-1.94 (m, 6 H), 1.33-1.56 (m, 3 H) 440.2 [M+H] + 98.5%
1244 (CD 3OD) δ 7.68 (s, 1 H), 7.21 (br d, 3 H), 6.80-7.12 (m, 0.8 H), 6.45-6.66 (m, 1.2 H), 6.25-6.39 (m, 1 H), 4.82 (br s, 0.3 H), 4.26-4.49 (m, 2.7 H), 3.83 (br s, 0.6 H), 3.37-3.48 (m, 0.4 H), 2.94-3.20 (m, 1 H), 2.83 (br d, 1 H), 1.55-1.70 (m, 9 H) 487.2 [M+H] + 99.9%
1245 (CD 3OD) δ 7.69 (s, 1 H), 7.11-7.41 (m, 3 H), 6.81-7.10 (m, 0.8 H), 6.48-6.67 (m, 1.2 H), 6.23-6.40 (m, 1 H), 4.76-4.81 (m, 0.3 H), 4.32-4.47 (m, 2.7 H), 3.83 (br s, 0.6 H), 3.38-3.48 (m, 0.4 H), 2.93-3.21 (m, 1 H), 2.84 (br d, 1 H), 1.54-1.71 (m, 9 H) 487.2 [M+H] + 99.8%
1246 (CD 3OD) δ 7.63-7.81 (m, 1 H), 7.42-7.55 (m, 1.4 H), 7.20-7.34 (m, 1 H), 6.93 (s, 0.6 H), 6.78 (d, 0.6 H), 6.59-6.73 (m, 1.4 H), 5.03 (br dd, 1 H), 3.71-3.87 (m, 0.6 H), 3.37-3.45 (m, 0.4 H), 3.08-3.23 (m, 0.7 H), 2.93-3.04 (m, 0.3 H), 2.83 (dd, 1 H), 2.27-2.41 (m, 1 H), 1.20-1.32 (m, 4 H) 394.1 [M+H] + 100%
1247 (CD 3OD) δ 7.70 (d, 1 H), 7.42-7.55 (m, 1.3 H), 7.21-7.33 (m, 1 H), 6.93 (s, 0.7 H), 6.78 (d, 0.7 H), 6.60-6.70 (m, 1.3 H), 5.03 (br dd, 1 H), 3.67-3.86 (m, 0.7 H), 3.37-3.44 (m, 0.3 H), 2.93-3.21 (m, 1 H), 2.75-2.89 (m, 1 H), 2.28-2.42 (m, 1 H), 1.23-1.32 (m, 4 H) 394.2 [M+H] + 97.1%
1248 (CD 3OD) δ 7.59-7.80 (m, 1 H), 7.40-7.53 (m, 1.3 H), 7.18-7.34 (m, 1 H), 6.95 (s, 0.7 H), 6.79 (d, 0.7 H), 6.59-6.72 (m, 1.3 H), 5.01 (br dd, 1 H), 3.70-3.92 (m, 0.7 H), 3.37-3.44 (m, 0.3 H), 3.08-3.22 (m, 0.7 H), 2.92-3.05 (m, 0.3 H), 2.86 (br s, 1 H), 1.45-1.53 (m, 9 H) 410.2 [M+H] + 100%
1249 (CD 3OD) δ 7.64-7.81 (m, 1 H), 7.41-7.55 (m, 1.3 H), 7.20-7.32 (m, 1 H), 6.95 (s, 0.7 H), 6.79 (d, 0.7 H), 6.66 (q, 1.3 H), 5.01 (br dd, 1 H), 3.71-3.92 (m, 0.6 H), 3.36-3.43 (m, 0.4 H), 3.10-3.23 (m, 0.7 H), 2.94-3.08 (m, 0.3 H), 2.84 (br dd, 1 H), 1.42-1.58 (m, 9 H) 410.2 [M+H] + 100%
1250 (CD 3OD) δ 8.46 (d, 1 H), 7.53-7.74 (m, 2 H), 7.21 (ddd, 1 H), 6.41-6.95 (m, 3 H), 4.05-4.55 (m, 1 H), 3.45-3.87 (m, 1 H), 2.77-3.18 (m, 2 H), 2.40 (s, 3 H), 1.66-1.90 (m, 6 H) 409.2 [M+H] + 99.8%
1251 (CD 3OD) δ 8.43-8.50 (m, 1 H), 7.55-7.76 (m, 2 H), 7.21 (ddd, 1 H), 6.40-6.96 (m, 3 H), 4.04-4.51 (m, 1 H), 3.47-3.88 (m, 1 H), 2.74-3.16 (m, 2 H), 2.40 (s, 3 H), 1.59-1.91 (m, 6 H) 409.2 [M+H] + 99.7%
1252 (CD 3OD) δ 7.67 (s, 1 H), 7.47 (br d, 1 H), 7.12 (dd, 1 H), 6.72 (d, 3 H), 4.14-4.52 (m, 1 H), 3.44-4.04 (m, 1 H), 2.78-3.12 (m, 2 H), 2.67 (s, 3 H), 2.38 (s, 3 H), 1.67-1.90 (m, 6 H) 423.2 [M+H] + 99.8%
1253 (CD 3OD) δ 7.67 (s, 1 H), 7.48 (br d, 1 H), 7.12 (dd, 1 H), 6.72 (d, 3 H), 4.10-4.52 (m, 1 H), 3.45-4.06 (m, 1 H), 2.78-3.14 (m, 2 H), 2.67 (s, 3 H), 2.38 (s, 3 H), 1.67-1.91 (m, 6 H) 423.2 [M+H] + 99.7%
1254 (CD 3OD) δ 8.43 (d, 1 H), 7.53-7.70 (m, 2 H), 6.99-7.30 (m, 2 H), 6.83-6.87 (m, 2 H), 6.53-6.62 (m, 1 H), 4.81 (br d, 0.4 H), 4.29 (br d, 0.6 H), 3.74 (br t, 0.6 H), 3.37-3.50 (m, 0.4 H), 2.71-3.15 (m, 2 H), 1.69-1.93 (m, 6 H) 445.2 [M+H] + 97.0%
1255 (CD 3OD) δ 8.44 (d, 1 H), 7.56-7.70 (m, 2 H), 7.00-7.30 (m, 2 H), 6.85 (br t, 2 H), 6.54-6.63 (m, 1 H), 4.77-4.83 (m, 0.4 H), 4.29 (br dd, 0.6 H), 3.74 (br t, 0.6 H), 3.37-3.47 (m, 0.4 H), 2.76-3.15 (m, 2 H), 1.69-1.90 (m, 6 H) 445.2 [M+H] + 98.4%
1256 (CD 3OD) δ 7.74 (br s, 1 H), 7.58 (s, 1 H), 7.12-7.34 (m, 2 H), 6.45-7.11 (m, 3 H), 4.01-4.41 (m, 0.7 H), 3.26-3.98 (m, 1.3 H), 2.80-3.07 (m, 1 H), 2.63-2.79 (m, 1 H), 1.45-1.98 (m, 6 H) 485.2 [M+H] + 99.3%
1257 (CD 3OD) δ 7.86 (br s, 1 H), 7.69 (s, 1 H), 7.33-7.40 (m, 1 H), 7.25-7.32 (m, 1 H), 6.62-7.24 (m, 3 H), 4.07-4.58 (m, 0.7 H), 3.34-4.07 (m, 1.3 H), 2.92-3.20 (m, 1 H), 2.83 (br dd, 1 H), 1.65-2.04 (m, 6 H) 485.2 [M+H] + 99.3%
1258 (CD 3OD) δ 9.42 (d, 1 H), 9.11 (d, 1 H), 8.27-8.42 (m, 2 H), 6.91-7.86 (m, 3 H), 6.75-6.90 (m, 2 H), 4.93-5.07 (m, 1 H), 3.43-3.89 (m, 1 H), 2.97-3.26 (m, 1 H), 2.88 (br dd, 1 H) 432.1 [M+H] + 100%
1259 (CD 3OD) δ 9.30 (d, 1 H), 9.00 (d, 1 H), 8.00-8.35 (m, 3 H), 6.82-7.56 (m, 2 H), 6.68-6.85 (m, 2 H), 4.82-5.04 (m, 1 H), 3.31-3.76 (m, 1 H), 2.89-3.18 (m, 1 H), 2.74-2.88 (m, 1 H) 432.2 [M+H] + 94.5%
1260 (CD 3OD) δ 8.30 (d, 1 H), 7.66 (s, 1 H), 6.98 (d, 1 H), 6.39-6.91 (m, 3 H), 4.74 (br s, 0.5 H), 4.27 (br d, 0.5 H), 3.73 (br s, 0.5 H), 3.36-3.50 (m, 0.5 H), 2.70-3.17 (m, 2 H), 2.35-2.48 (m, 6 H), 1.64-1.90 (m, 6 H) 423.2 [M+H] + 100%
1261 (CD 3OD) δ 8.29 (d, 1 H), 7.67 (s, 1 H), 6.97 (d, 1 H), 6.40-6.91 (m, 3 H), 4.75 (br s, 0.5 H), 4.27 (br d, 0.5 H), 3.74 (br s, 0.5 H), 3.36-3.56 (m, 0.5 H), 2.69-3.18 (m, 2 H), 2.34-2.50 (m, 6 H), 1.63-1.91 (m, 6 H) 423.2 [M+H] + 99.6%
1262 (CD 3OD) δ 8.69 (d, 1 H), 7.57-7.75 (m, 2 H), 6.98 (t, 1 H), 6.40-6.93 (m, 2 H), 4.71-4.81 (m, 0.5 H), 4.31 (br d, 0.5 H), 3.72 (br s, 0.5 H), 3.38-3.55 (m, 0.5 H), 2.73-3.16 (m, 2 H), 2.39 (s, 3 H), 1.61-1.93 (m, 6 H) 477.2 [M+H] + 100%
1263 (CD 3OD) δ 8.69 (d, 1 H), 7.52-7.82 (m, 2 H), 6.98 (t, 1 H), 6.32-6.93 (m, 2 H), 4.78 (br s, 0.5 H), 4.31 (br d, 0.5 H), 3.72 (br s, 0.5 H), 3.46 (br d, 0.5 H), 2.72-3.22 (m, 2 H), 2.39 (s, 3 H), 1.62-1.91 (m, 6 H) 477.2 [M+H] + 100%
1264 (CD 3OD) δ 7.74 (br d, 1 H), 7.56 (s, 1 H), 7.21-7.26 (m, 1 H), 7.11-7.19 (m, 1 H), 6.45-6.87 (m, 2 H), 4.50 (br s, 0.5 H), 4.05-4.31 (m, 0.5 H), 3.72-3.89 (m, 0.5 H), 3.23-3.39 (m, 0.5 H), 2.64-2.98 (m, 2 H), 2.25 (s, 3 H), 1.55-1.79 (m, 6 H) 477.2 [M+H] + 100%
1265 (CD 3OD) δ 7.87 (br d, 1 H), 7.68 (s, 1 H), 7.36 (br d, 1 H), 7.24-7.32 (m, 1 H), 6.55-6.97 (m, 2 H), 4.62 (br s, 0.5 H), 4.17-4.44 (m, 0.5 H), 3.79-4.04 (m, 0.5 H), 3.37-3.56 (m, 0.5 H), 2.78-3.10 (m, 2 H), 2.37 (s, 3 H), 1.66-1.90 (m, 6 H) 477.2 [M+H] + 98.4%
1266 (CD 3OD) δ 7.67 (s, 1 H), 7.62 (br d, 1 H), 7.17-7.22 (m, 1 H), 7.05 (d, 1 H), 6.80 (br d, 2 H), 4.62 (s, 0.5 H), 4.23-4.41 (m, 0.5 H), 3.76-4.00 (m, 0.5 H), 3.39-3.55 (m, 0.5 H), 2.79-3.13 (m, 2 H), 2.40 (s, 3 H), 1.71-1.90 (m, 6 H) 443.1 [M+H] + 100%
1267 (CD 3OD) δ 7.55 (s, 1 H), 7.49 (br d, 1 H), 7.06 (dd, 1 H), 6.92 (d, 1 H), 6.40-6.80 (m, 2 H), 4.50 (s, 0.5 H), 4.16-4.31 (m, 0.5 H), 3.68-3.86 (m, 0.5 H), 3.24-3.41 (m, 0.5 H), 2.67-3.00 (m, 2 H), 2.27 (s, 3 H), 1.59-1.77 (m, 6 H) 443.1 [M+H] + 99.8%
1268 (CD 3OD) δ 7.87 (br d, 1 H), 7.69 (br s, 1 H), 7.33-7.40 (m, 1 H), 7.24-7.33 (m, 1 H), 6.94-7.23 (m, 1 H), 6.74 – 6.98 (m, 2 H), 4.40 (br s, 1 H), 3.90 (br s, 1 H), 2.68-3.24 (m, 2 H), 1.19-1.46 (m, 4 H) 509.2 [M+H] + 98.1%
1269 (CD 3OD) δ 7.87 (br d, 1 H), 7.69 (br s, 1 H), 7.32-7.42 (m, 1 H), 7.25-7.32 (m, 1 H), 7.08 (br s, 1 H), 6.72-6.96 (m, 2 H), 4.40 (br s, 1 H), 3.90 (br s, 1 H), 2.61-3.20 (m, 2 H), 1.33 (br d, 4 H) 509.2 [M+H] + 95.2%
1270 (CD 3OD) δ 8.15-8.87 (m, 3 H), 7.96 (d, 1 H), 7.59-7.71 (m, 2 H), 7.44 (ddd, 1 H), 6.49-7.14 (m, 4 H), 4.60 (br s, 1 H), 3.33-3.89 (m, 1 H), 3.01-3.13 (m, 1 H), 2.78 (br dd, 1 H) 452.2 [M+H] + 100%
1271 (CD 3OD) δ 8.23-9.01 (m, 3 H), 7.97 (d, 1 H), 7.60-7.71 (m, 2 H), 7.40-7.48 (m, 1 H), 6.47-7.14 (m, 4 H), 4.62 (br s, 1 H), 3.35-3.96 (m, 1 H), 3.04-3.14 (m, 1 H), 2.74-2.83 (m, 1 H) 452.2 [M+H] + 98.8%
1272 (CD 3OD) δ 6.58-7.25 (m, 3 H), 6.36-6.44 (m, 1 H), 6.09 (s, 1 H), 5.85 (ddd, 1 H), 5.70 (d, 1 H), 4.78-5.58 (m, 4 H), 3.06 (br s, 1 H), 1.79-2.37 (m, 1 H), 1.44-1.55 (m, 1 H), 1.19 (br dd, 1 H) 418.1 [M+H] + 97.4%
1273 (CD 3OD) δ 8.21-8.83 (m, 3 H), 7.97 (d, 1 H), 7.67 (s, 1 H), 7.43 (dd, 1 H), 7.29 (d, 1 H), 6.43-7.13 (m, 4 H), 4.61 (br s, 1 H), 3.35-3.95 (m, 1 H), 3.01-3.13 (m, 1 H), 2.77 (br dd, 1 H) 418.1 [M+H] + 98.4%
1274 (CD 3OD) δ 8.33 (br d, 1 H), 7.67 (s, 1 H), 6.41-7.05 (m, 4 H), 4.77 (br s, 0.5 H), 4.30 (br s, 0.5 H), 3.73 (br s, 0.5 H), 3.39 (br s, 0.5 H), 2.71-3.15 (m, 2 H), 2.38 (s, 3 H), 1.64-1.92 (m, 6 H) 427.2 [M+H] + 100%
1275 (CD 3OD) δ 8.34 (d, 1 H), 7.67 (s, 1 H), 6.40-7.07 (m, 4 H), 4.77 (br s, 0.5 H), 4.29 (br d, 0.5 H), 3.72 (br s, 0.5 H), 3.48 (br s, 0.5 H), 2.74-3.17 (m, 2 H), 2.38 (s, 3 H), 1.65-1.87 (m, 6 H) 427.2 [M+H] + 98.1%
1276 (CD 3OD) δ 8.44 (d, 1 H), 7.67 (s, 1 H), 7.29 (d, 1 H), 6.39-6.97 (m, 3 H), 4.77 (br s, 0.5 H), 4.29 (br d, 0.5 H), 3.72 (br s, 0.5 H), 3.37-3.52 (m, 0.5 H), 2.76-3.16 (m, 2 H), 2.39 (s, 3 H), 1.68-1.91 (m, 6 H) 443.2 [M+H] + 100%
1277 (CD 3OD) δ 8.44 (br d, 1 H), 7.67 (br s, 1 H), 7.29 (d, 1 H), 6.40-7.02 (m, 3 H), 4.76 (br s, 0.5 H), 4.29 (br s, 0.5 H), 3.72 (br s, 0.5 H), 3.40 (br s, 0.5 H), 2.70-3.15 (m, 2 H), 2.39 (s, 3 H), 1.63-1.90 (m, 6 H) 443.2 [M+H] + 98.5%
1278 (CD 3OD) δ 7.68 (s, 1 H), 7.47 (br d, 1 H), 7.24 (ddd, 1 H), 6.42-7.00 (m, 3 H), 4.91-5.12 (m, 0.5 H), 4.32 (dt, 0.5 H), 3.38-3.94 (m, 1 H), 2.72-3.15 (m, 2 H), 2.40 (s, 3 H), 1.67-1.91 (m, 6 H) 427.1 [M+H] + 100%
1279 (CD 3OD) δ 7.68 (s, 1 H), 7.47 (br d, 1 H), 7.24 (ddd, 1 H), 6.52-6.89 (m, 3 H), 4.93-5.07 (m, 0.5 H), 4.25-4.38 (m, 0.5 H), 3.46-3.96 (m, 1 H), 2.80-3.15 (m, 2 H), 2.40 (s, 3 H), 1.70-1.89 (m, 6 H) 427.1 [M+H] + 99.9%
1280 (CD 3OD) δ 7.70 (s, 1 H), 7.48 (br d, 1 H), 6.96-7.27 (m, 2 H), 6.67-6.91 (m, 2 H), 6.46-6.64 (m, 1 H), 4.42 (br s, 1 H), 3.87 (br s, 1 H), 2.77-3.15 (m, 2 H), 2.67 (br s, 3 H), 1.26-1.41 (m, 4 H) 455.2 [M+H] + 98.1%
1281 (CD 3OD) δ 7.68 (s, 1 H), 7.48 (br d, 1 H), 6.96-7.27 (m, 2 H), 6.65-6.91 (m, 2 H), 6.43-6.63 (m, 1 H), 4.40 (br s, 1 H), 3.88 (br s, 1 H), 2.82 (br d, 2 H), 2.67 (br s, 3 H), 1.27-1.44 (m, 4 H) 455.2 [M+H] + 100%
1282 (CD 3OD) δ 8.52-8.62 (m, 1 H), 7.69 (s, 1 H), 7.38-7.51 (m, 1.3 H), 7.08-7.14 (m, 0.2 H), 6.70-7.01 (m, 3.5 H), 4.97 (br dd, 1 H), 3.65-3.83 (m, 0.5 H), 3.35-3.41 (m, 0.5 H), 2.79-3.18 (m, 2 H), 2.59-2.69 (m, 3 H) 400.2 [M+H] + 100%
1283 (CD 3OD) δ 8.52-8.63 (m, 1 H), 7.69 (s, 1 H), 7.37-7.52 (m, 1.3 H), 7.07-7.14 (m, 0.2 H), 6.70-7.02 (m, 3.5 H), 4.97 (br dd, 1 H), 3.67-3.78 (m, 0.5 H), 3.35-3.42 (m, 0.5 H), 2.78-3.18 (m, 2 H), 2.61-2.69 (m, 3 H) 400.2 [M+H] + 100%
1284 (CD 3OD) δ 8.46 (br d, 1 H), 7.54-7.73 (m, 2 H), 7.43-7.49 (m, 0.3 H), 7.14-7.25 (m, 1 H), 6.85-6.94 (m, 1.7 H), 6.51-6.67 (m, 1 H), 4.97 (br s, 1 H), 3.38-3.82 (m, 1 H), 2.81-3.20 (m, 2 H), 1.61 (s, 3 H), 1.39-1.46 (m, 2 H), 1.11 (d, 2 H) 390.2 [M+H] + 100%
1285 (CD 3OD) δ 8.40-8.52 (m, 1 H), 7.54-7.76 (m, 2 H), 7.46 (s, 0.3 H), 7.14-7.26 (m, 1 H), 6.83-6.97 (m, 1.7 H), 6.53-6.66 (m, 1 H), 5.00 (br d, 1 H), 3.40-3.79 (m, 1 H), 2.80-3.19 (m, 2 H), 1.61 (s, 3 H), 1.39-1.46 (m, 2 H), 1.11 (d, 2 H) 390.2 [M+H] + 94.1%
1286 (CD 3OD) δ 8.24-8.88 (m, 3 H), 7.97 (d, 1 H), 7.66 (s, 1 H), 7.44 (dd, 1 H), 6.32-7.19 (m, 5 H), 4.61-4.74 (m, 1 H), 3.39-3.95 (m, 1 H), 3.02-3.12 (m, 1 H), 2.77 (br dd, 1 H), 2.44 (s, 3 H) 398.2 [M+H] + 100%
1287 (CD 3OD) δ 8.20-9.02 (m, 3 H), 7.97 (d, 1 H), 7.66 (s, 1 H), 7.39-7.48 (m, 1 H), 6.38-7.12 (m, 5 H), 4.60-4.78 (m, 1 H), 3.36-3.94 (m, 1 H), 3.01-3.12 (m, 1 H), 2.77 (br dd, 1 H), 2.44 (s, 3 H) 398.2 [M+H] + 98.9%
1288 (CD 3OD) δ 8.21-8.92 (m, 3 H), 7.97 (d, 1 H), 7.66 (s, 1 H), 7.41-7.46 (m, 1 H), 6.47-7.11 (m, 5 H), 4.62 (br s, 1 H), 3.33-3.92 (m, 1 H), 3.02-3.14 (m, 1 H), 2.77 (br dd, 1 H) 402.2 [M+H] + 100%
1289 (CD 3OD) δ 8.20-8.90 (m, 3 H), 7.96 (d, 1 H), 7.66 (s, 1 H), 7.43 (dd, 1 H), 6.48-7.12 (m, 5 H), 4.62 (br s, 1 H), 3.34-3.93 (m, 1 H), 3.01-3.14 (m, 1 H), 2.77 (br dd, 1 H) 402.2 [M+H] + 100%
1290 (CD 3OD) δ 8.69 (d, 1 H), 8.44 (d, 1 H), 8.13 (d, 1 H), 8.00 (td, 1 H), 7.69 (s, 1 H), 7.51-7.61 (m, 2 H), 7.12-7.23 (m, 1 H), 6.84 (t, 1 H), 6.64 (s, 1 H), 6.53 (s, 1 H), 4.44 (dd, 1 H), 3.69-3.85 (m, 1 H), 3.02-3.17 (m, 1 H), 2.84 (dd, 1 H) 385.1 [M+H] + 99.3%
1291 (CD 3OD) δ 8.69 (d, 1 H), 8.44 (d, 1 H), 8.13 (d, 1 H), 7.96-8.05 (m, 1 H), 7.69 (s, 1 H), 7.52-7.63 (m, 2 H), 7.18 (dd, 1 H), 6.85 (t, 1 H), 6.64 (s, 1 H), 6.54 (s, 1 H), 4.44 (dd, 1 H), 3.75-3.87 (m, 1 H), 3.04-3.17 (m, 1 H), 2.85 (dd, 1 H) 385.1 [M+H] + 96.9%
1292 (CD 3OD) δ 9.31 (s, 1 H), 8.80 (d, 1 H), 8.33-8.61 (m, 2 H), 7.64-7.77 (m, 2 H), 7.56 (s, 0.3 H), 7.23-7.37 (m, 1 H), 6.97 (s, 0.7 H), 6.68-6.92 (m, 2 H), 5.10 (br dd, 1 H), 3.73-3.86 (m, 0.7 H), 3.43 (td, 0.3 H), 2.79-3.26 (m, 2 H) 447.1 [M+H] + 100%
1293 (CD 3OD) δ 9.31 (s, 1 H), 8.80 (d, 1 H), 8.32-8.60 (m, 2 H), 7.64-7.76 (m, 2 H), 7.56 (s, 0.3 H), 7.25-7.35 (m, 1 H), 6.97 (s, 0.7 H), 6.68-6.90 (m, 2 H), 5.10 (dd, 1 H), 3.66-3.89 (m, 0.7 H), 3.43 (td, 0.3 H), 2.82-3.25 (m, 2 H) 447.1 [M+H] + 98.5%
1294 (CD 3OD) δ 8.67 (d, 1 H), 8.40-8.52 (m, 1 H), 7.94 (d, 1 H), 7.69-7.83 (m, 2 H), 7.47 (s, 0.4 H), 7.26-7.38 (m, 1 H), 6.99 (s, 0.6 H), 6.77-6.92 (m, 2 H), 4.95-5.03 (m, 1 H), 3.76-3.86 (m, 0.5 H), 3.42-3.51 (m, 0.5 H), 3.02-3.24 (m, 1 H), 2.88 (br d, 1 H) 465.1 [M+H] + 99.9%
1295 (CD 3OD) δ 8.67 (d, 1 H), 8.36-8.53 (m, 1 H), 7.95 (t, 1 H), 7.71-7.80 (m, 2 H), 7.47 (s, 0.3 H), 7.21-7.36 (m, 1 H), 6.99 (s, 0.7 H), 6.77-6.92 (m, 2 H), 4.98 (br d, 1 H), 3.71-3.93 (m, 0.5 H), 3.40-3.55 (m, 0.5 H), 2.99-3.29 (m, 1 H), 2.81-2.96 (m, 1 H) 465.1 [M+H] + 99.5%
1296 (CD 3OD) δ 7.69 (d, 1 H), 7.56-7.65 (m, 1 H), 7.44 (s, 0.4 H), 7.14-7.23 (m, 1 H), 7.05 (d, 1 H), 6.94 (s, 0.6 H), 6.61-6.81 (m, 1 H), 4.92-5.07 (m, 1 H), 3.80-3.92 (m, 0.6 H), 3.35-3.42 (m, 0.4 H), 2.81-3.19 (m, 2 H), 1.60 (s, 3 H), 1.38-1.46 (m, 2 H), 1.10 (d, 2 H) 424.2 [M+H] + 100%
1297 (CD 3OD) δ 7.58 (d, 1 H), 7.44-7.53 (m, 1 H), 7.32 (s, 0.4 H), 7.03-7.11 (m, 1 H), 6.90-6.96 (m, 1 H), 6.83 (s, 0.6 H), 6.50-6.69 (m, 1 H), 4.90 (br dd, 1 H), 3.75 (ddd, 0.6 H), 3.28 (br d, 0.4 H), 2.74 (br d, 2 H), 1.48 (s, 3 H), 1.29 (br d, 2 H), 0.98 (d, 2 H) 424.1 [M+H] + 92.3%
1298 (CD 3OD) δ 8.80-9.04 (m, 1 H), 8.39-8.60 (m, 2 H), 8.29 (d, 1 H), 7.82 (s, 0.3 H), 7.64 (dd, 1 H), 7.26-7.43 (m, 1 H), 7.20 (s, 0.7 H), 7.06 (s, 0.3 H), 6.89-6.97 (m, 1.7 H), 5.25 (br dd, 1 H), 4.01 (s, 3 H), 3.65-3.84 (m, 1 H), 3.38-3.55 (m, 1 H), 2.94-3.19 (m, 1 H) 477.2 [M+H] + 90.8%
1299 (CD 3OD) δ 8.87-9.06 (m, 1 H), 8.41-8.65 (m, 2 H), 8.28 (br d, 1 H), 7.82 (s, 0.3 H), 7.63 (dd, 1 H), 7.38 (d, 1 H), 7.20 (s, 0.7 H), 7.06 (s, 0.3 H), 6.86-6.97 (m, 1.7 H), 5.25 (br dd, 1 H), 4.01 (s, 3 H), 3.75 (br t, 1 H), 3.38-3.54 (m, 1 H), 2.93-3.18 (m, 1 H) 477.1 [M+H] + 94.0%
1300 (CD 3OD) δ 9.48 (d, 1 H), 8.81-8.90 (m, 2 H), 8.63-8.76 (m, 1 H), 7.73-7.84 (m, 1 H), 7.59-7.73 (m, 1 H), 6.80-7.57 (m, 3 H), 4.94-5.13 (m, 1 H), 3.40-3.91 (m, 1 H), 2.81-3.28 (m, 2 H) 482.2 [M+H] + 100%
1301 (CD 3OD) δ 9.48 (s, 1 H), 8.81-9.04 (m, 2 H), 8.63-8.81 (m, 1 H), 7.73-7.91 (m, 1 H), 7.59-7.72 (m, 1 H), 6.79-7.59 (m, 3 H), 5.07 (br dd, 1 H), 3.41-3.96 (m, 1 H), 2.82-3.30 (m, 2 H) 482.1 [M+H] + 99.9%
1302 (CD 3OD) δ 9.31 (br s, 1 H), 8.46-8.83 (m, 3 H), 7.71 (s, 3.5 H), 6.91-7.04 (m, 1.5 H), 6.66-6.87 (m, 1 H), 5.12 (dd, 0.7 H), 4.95 (br dd, 0.3 H), 3.70-3.86 (m, 0.7 H), 3.37-3.50 (m, 0.3 H), 2.78-3.26 (m, 2 H) 481.1 [M+H] + 100%
1303 (CD 3OD) δ 9.31 (d, 1 H), 8.48-8.87 (m, 3 H), 7.54-7.74 (m, 3.5 H), 6.92-7.06 (m, 1.5 H), 6.73-6.85 (m, 1 H), 5.12 (dd, 0.7 H), 4.95 (br dd, 0.3 H), 3.75-3.84 (m, 0.7 H), 3.43 (td, 0.3 H), 2.82-3.26 (m, 2 H) 481.1 [M+H] + 99.3%
1304 (CD 3OD) δ 8.61-8.72 (m, 2 H), 8.42-8.49 (m, 1 H), 7.71 (s, 1 H), 7.46-7.66 (m, 2 H), 6.94-7.03 (m, 2 H), 6.77-6.83 (m, 1 H), 5.12 (dd, 0.6 H), 4.95 (br dd, 0.4 H), 3.80 (td, 0.7 H), 3.42 (td, 0.3 H), 3.17-3.26 (m, 1 H), 2.81-3.05 (m, 4 H) 495.1 [M+H] + 100%
1305 (CD 3OD) δ 8.61-8.72 (m, 2 H), 8.41-8.49 (m, 1 H), 7.71 (s, 1 H), 7.45-7.66 (m, 2 H), 6.94-7.02 (m, 2 H), 6.78-6.83 (m, 1 H), 5.12 (br dd, 0.6 H), 4.92-4.97 (m, 0.4 H), 3.75-3.85 (m, 0.7 H), 3.42 (td, 0.3 H), 3.15-3.27 (m, 1 H), 2.82-3.06 (m, 4 H) 495.1 [M+H] + 99.6%
1306 (CD 3OD) δ 9.31 (s, 1 H), 8.75-8.90 (m, 1 H), 8.44-8.63 (m, 1 H), 7.50-7.73 (m, 3.5 H), 7.11-7.25 (m, 1 H), 6.98-7.06 (m, 1.5 H), 6.80 (s, 0.6 H), 6.65 (s, 0.4 H), 5.12 (dd, 0.6 H), 4.95 (br dd, 0.4 H), 3.87-4.00 (m, 0.6 H), 3.40 (td, 0.4 H), 2.97-3.25 (m, 1 H), 2.87 (dd, 1 H) 447.2 [M+H] + 100%
1307 (CD 3OD) δ 9.31 (br s, 1 H), 8.74-8.85 (m, 1 H), 8.55 (br d, 1 H), 7.47-7.73 (m, 3.5 H), 7.11-7.22 (m, 1 H), 6.95-7.07 (m, 1.5 H), 6.80 (s, 0.6 H), 6.64 (s, 0.4 H), 5.11 (br dd, 0.6 H), 4.95 (br dd, 0.4 H), 3.87-3.98 (m, 0.6 H), 3.40 (td, 0.4 H), 2.96-3.26 (m, 1 H), 2.87 (br dd, 1 H) 447.1 [M+H] + 95.4%
1308 (CD 3OD) δ 9.31 (br s, 1 H), 8.80 (br d, 1 H), 8.55 (br d, 1 H), 7.85 (d, 1 H), 7.67 (br d, 1 H), 7.39-7.53 (m, 1.4 H), 7.06-7.18 (m, 1 H), 7.03 (s, 0.6 H), 6.61-6.75 (m, 1.6 H), 6.50 (s, 0.4 H), 5.10 (br dd, 0.6 H), 4.95 (br d, 0.4 H), 3.87-3.99 (m, 0.6 H), 3.37-3.46 (m, 0.4 H), 2.83-3.26 (m, 2 H), 2.49-2.68 (m, 3 H) 427.2 [M+H] + 100%
1309 (CD 3OD) δ 9.31 (s, 1 H), 8.72-8.94 (m, 1 H), 8.54 (br d, 1 H), 7.62-7.81 (m, 2 H), 7.37-7.55 (m, 1.4 H), 7.05-7.17 (m, 1 H), 7.00 (s, 0.6 H), 6.59-6.76 (m, 1.6 H), 6.48 (s, 0.4 H), 5.08 (br dd, 0.5 H), 4.95 (br d, 0.5 H), 3.89-3.98 (m, 0.5 H), 3.41 (td, 0.5 H), 2.83-3.25 (m, 2 H), 2.48-2.70 (m, 3 H) 427.2 [M+H] + 96.9%
1310 (CD 3OD) δ 9.05 (d, 2 H), 8.21-8.40 (m, 1 H), 7.69-7.75 (m, 2 H), 6.76-7.05 (m, 3 H), 6.61-6.69 (m, 1 H), 4.98 (br d, 1 H), 3.79-3.86 (m, 0.5 H), 3.46-3.50 (m, 0.5 H), 2.85-3.21 (m, 2 H), 2.44-2.49 (m, 3 H) 428.1 [M+H] + 100%
1311 (CD 3OD) δ 9.00-9.10 (m, 2 H), 8.21-8.37 (m, 1 H), 7.67-7.75 (m, 2 H), 7.48 (s, 0.3 H), 6.76-7.03 (m, 2.7 H), 6.60-6.71 (m, 1 H), 4.97-5.01 (m, 1 H), 3.79-3.87 (m, 0.5 H), 3.46 (br d, 0.5 H), 2.84-3.26 (m, 2 H), 2.42-2.50 (m, 3 H) 428.1 [M+H] + 98.6%
1312 (CD 3OD) δ 9.03-9.07 (m, 2 H), 8.28-8.41 (m, 1 H), 7.66-7.75 (m, 2 H), 7.38-7.55 (m, 0.3 H), 6.73-7.07 (m, 3.7 H), 4.95-5.04 (m, 1 H), 3.81-3.86 (m, 0.6 H), 3.42-3.51 (m, 0.4 H), 2.83-3.24 (m, 2 H) 432.2 [M+H] + 100%
1313 (CD 3OD) δ 9.05 (d, 2 H), 8.27-8.41 (m, 1 H), 7.67-7.77 (m, 2 H), 7.47 (br s, 0.3 H), 6.78-7.03 (m, 3.7 H), 4.96-5.05 (m, 1 H), 3.79-3.87 (m, 0.6 H), 3.42-3.50 (m, 0.4 H), 2.85-3.27 (m, 2 H) 432.2 [M+H] + 99.6%
1314 (CD 3OD) δ 8.77 (d, 1 H), 8.50-8.64 (m, 1 H), 8.31 (d, 1 H), 8.02-8.16 (m, 1 H), 7.61-7.76 (m, 2 H), 7.52 (s, 0.2 H), 7.37-7.47 (m, 1 H), 6.75-7.17 (m, 3.8 H), 4.93-5.07 (m, 1 H), 3.72-3.86 (m, 0.5 H), 3.42 (td, 0.5 H), 2.80-3.27 (m, 2 H) 463.2 [M+H] + 100%
1315 (CD 3OD) δ 8.77 (d, 1 H), 8.49-8.64 (m, 1 H), 8.31 (d, 1 H), 8.08 (t, 1 H), 7.62-7.75 (m, 2 H), 7.52 (s, 0.2 H), 7.37-7.48 (m, 1 H), 6.77-7.15 (m, 3.8 H), 4.93-5.06 (m, 1 H), 3.71-3.85 (m, 0.5 H), 3.42 (td, 0.5 H), 2.81-3.26 (m, 2 H) 463.2 [M+H] + 99.1%
1316 (CD 3OD) δ 8.50-8.63 (m, 1 H), 8.36-8.45 (m, 1 H), 8.04-8.15 (m, 1 H), 7.70 (s, 1 H), 7.58 (s, 0.2 H), 7.37-7.49 (m, 1 H), 6.67-7.18 (m, 3.8 H), 5.09 (dd, 0.5 H), 4.93 (br d, 0.5 H), 4.00 (s, 3 H), 3.69-3.83 (m, 0.5 H), 3.35-3.45 (m, 0.5 H), 2.74-3.24 (m, 2 H) 466.2 [M+H] + 100%
1317 (CD 3OD) δ 8.51-8.62 (m, 1 H), 8.33-8.43 (m, 1 H), 8.02-8.17 (m, 1 H), 7.70 (s, 1 H), 7.58 (s, 0.2 H), 7.34-7.47 (m, 1 H), 6.70-7.17 (m, 3.8 H), 5.09 (dd, 0.5 H), 4.93 (br d, 0.5 H), 4.00 (s, 3 H), 3.69-3.82 (m, 0.5 H), 3.39 (td, 0.5 H), 2.79-3.23 (m, 2 H) 466.2 [M+H] + 100%
1318 (CD 3OD) δ 7.68 (d, 1 H), 7.35-7.52 (m, 1.5 H), 7.08-7.16 (m, 1 H), 6.95 (s, 0.5 H), 6.43-6.76 (m, 2 H), 4.93-5.03 (m, 1 H), 3.83-3.92 (m, 0.6 H), 3.36-3.42 (m, 0.4 H), 2.82-3.17 (m, 2 H), 2.61-2.69 (m, 3 H), 1.61 (s, 3 H), 1.38-1.44 (m, 2 H), 1.08-1.13 (m, 2 H) 404.2 [M+H] + 100%
1319 (CD 3OD) δ 7.71 (d, 1 H), 7.36 (dd, 1.5 H), 7.07-7.17 (m, 1 H), 6.96 (s, 0.5 H), 6.42-6.78 (m, 2 H), 4.99 (br dd, 1 H), 3.77-3.94 (m, 0.6 H), 3.40 (br d, 0.4 H), 2.81-3.14 (m, 2 H), 2.61-2.69 (m, 3 H), 1.61 (s, 3 H), 1.38-1.46 (m, 2 H), 1.08-1.14 (m, 2 H) 404.2 [M+H] + 99.6%
1320 (CD 3OD) δ 8.19-8.75 (m, 1 H), 7.71 (s, 1 H), 7.24-7.54 (m, 1.4 H), 6.83-6.96 (m, 1.6 H), 6.68-6.77 (m, 1 H), 5.01 (dd, 0.8 H), 4.87 (br s, 0.2 H), 3.35-3.80 (m, 1 H), 2.90-3.23 (m, 1 H), 2.83 (br d, 1 H), 1.54-1.68 (m, 3 H), 1.36-1.48 (m, 2 H), 1.06-1.16 (m, 2 H) 424.2 [M+H] + 100%
1321 (CD 3OD) δ 8.22-8.66 (m, 1 H), 7.71 (s, 1 H), 7.17-7.55 (m, 1.5 H), 6.81-6.98 (m, 1.5 H), 6.67-6.79 (m, 1 H), 5.01 (br dd, 0.8 H), 4.87 (br s, 0.2 H), 3.36-3.80 (m, 1 H), 2.91-3.23 (m, 1 H), 2.83 (br d, 1 H), 1.51-1.66 (m, 3 H), 1.36-1.49 (m, 2 H), 1.04-1.17 (m, 2 H) 424.2 [M+H] + 100%
1322 (CD 3OD) δ 8.09-8.55 (m, 1 H), 7.70 (s, 1 H), 7.37-7.52 (m, 0.3 H), 6.86-7.06 (m, 1.7 H), 6.76-6.84 (m, 1 H), 6.51-6.67 (m, 1 H), 4.98 (dd, 0.8 H), 4.85 (br d, 0.2 H), 3.36-3.84 (m, 1 H), 2.90-3.24 (m, 1 H), 2.73-2.89 (m, 1 H), 2.44-2.50 (m, 3 H), 1.61 (s, 3 H), 1.35-1.49 (m, 2 H), 1.04-1.18 (m, 2 H) 404.2 [M+H] + 100%
1323 (CD 3OD) δ 8.13-8.50 (m, 1 H), 7.70 (s, 1 H), 7.36-7.53 (m, 0.3 H), 6.86-7.10 (m, 1.7 H), 6.74-6.86 (m, 1 H), 6.50-6.68 (m, 1 H), 4.99 (br dd, 1 H), 3.40-3.80 (m, 1 H), 3.15 (br s, 1 H), 2.76-2.90 (m, 1 H), 2.44-2.50 (m, 3 H), 1.61 (s, 3 H), 1.37-1.49 (m, 2 H), 1.03-1.22 (m, 2 H) 404.2 [M+H] + 100%
1324 (CD 3OD) δ 8.44-8.80 (m, 1 H), 7.59-7.77 (m, 2 H), 7.42-7.48 (m, 0.3 H), 6.83-7.12 (m, 1.7 H), 6.73-6.82 (m, 1 H), 5.03 (br dd, 0.8 H), 4.88 (br s, 0.2 H), 3.37-3.80 (m, 1 H), 2.92-3.24 (m, 1 H), 2.83 (br d, 1 H), 1.57-1.65 (m, 3 H), 1.36-1.48 (m, 2 H), 1.03-1.21 (m, 2 H) 458.2 [M+H] + 100%
1325 (CD 3OD) δ 8.71 (br d, 1 H), 7.60-7.75 (m, 2 H), 7.45 (br d, 0.3 H), 6.84-7.10 (m, 1.7 H), 6.69-6.83 (m, 1 H), 5.03 (dd, 0.8 H), 4.86-4.89 (m, 0.2 H), 3.40-3.80 (m, 1 H), 3.15 (br d, 1 H), 2.83 (br d, 1 H), 1.57-1.65 (m, 3 H), 1.38-1.49 (m, 2 H), 1.07-1.15 (m, 2 H) 458.2 [M+H] + 100%
1326 (CD 3OD) δ 8.11-8.93 (m, 3 H), 7.96 (d, 1 H), 7.65 (s, 1 H), 7.43 (dd, 1 H), 6.29-7.25 (m, 5 H), 4.31-4.86 (m, 1 H), 3.95 (s, 3 H), 3.34-3.87 (m, 1 H), 2.98-3.14 (m, 1 H), 2.76 (br dd, 1 H) 414.2 [M+H]+ 100%
1327 (CD 3OD) δ 8.05-8.87 (m, 3 H), 7.97 (d, 1 H), 7.65 (s, 1 H), 7.39-7.48 (m, 1 H), 6.23-7.15 (m, 5 H), 4.60 (br s, 1 H), 3.95 (s, 3 H), 3.38-3.80 (m, 1 H), 3.00-3.12 (m, 1 H), 2.76 (br d, 1 H) 414.2 [M+H]+ 100%
1328 (CD 3OD) δ 8.61-8.66 (m, 1 H), 8.44 (dd, 1 H), 8.27-8.36 (m, 1 H), 7.70 (br s, 1 H), 7.44-7.57 (m, 1 H), 6.90-7.03 (m, 2 H), 6.73-6.86 (m, 2 H), 5.10 (br dd, 0.6 H), 4.94 (br d, 0.4 H), 3.74-3.84 (m, 0.6 H), 3.38-3.47 (m, 0.4 H), 2.84-3.25 (m, 5 H) 445.2 [M+H] + 100%
1329 (CD 3OD) δ 8.61-8.66 (m, 1 H), 8.44 (dd, 1 H), 8.27-8.36 (m, 1 H), 7.70 (br s, 1 H), 7.44-7.57 (m, 1 H), 6.90-7.03 (m, 2 H), 6.73-6.86 (m, 2 H), 5.10 (br dd, 0.6 H), 4.94 (br d, 0.4 H), 3.74-3.84 (m, 0.6 H), 3.38-3.47 (m, 0.4 H), 2.84-3.25 (m, 5 H) 445.2 [M+H] + 99.7%
1330 (CD 3OD) δ 8.64 (d, 1 H), 8.43-8.48 (m, 1 H), 8.24-8.33 (m, 1 H), 7.69 (s, 1 H), 7.46-7.54 (m, 1 H), 6.95-7.03 (m, 2 H), 6.73-6.81 (m, 1 H), 6.57-6.66 (m, 1 H), 5.07 (dd, 0.6 H), 4.90-4.94 (m, 0.4 H), 3.76-3.86 (m, 0.6 H), 3.40-3.49 (m, 0.4 H), 2.82-3.26 (m, 5 H), 2.41-2.47 (m, 3 H) 441.2 [M+H] + 100%
1331 (CD 3OD) δ 8.64 (br d, 1 H), 8.43-8.48 (m, 1 H), 8.24-8.32 (m, 1 H), 7.70 (s, 1 H), 7.46-7.53 (m, 1 H), 6.95-7.02 (m, 2 H), 6.74-6.82 (m, 1 H), 6.58-6.66 (m, 1 H), 5.08 (br dd, 0.7 H), 4.90-4.95 (m, 0.3 H), 3.77-3.86 (m, 0.6 H), 3.44 (td, 0.4 H), 2.80-3.26 (m, 5 H), 2.40-2.47 (m, 3 H) 441.2 [M+H] + 99.2%
1332 (CD 3OD) δ 9.36 (d, 1 H), 8.66-8.84 (m, 2 H), 8.24-8.43 (m, 1 H), 7.63 (br s, 1 H), 6.84-7.43 (m, 2 H), 6.62-6.82 (m, 2 H), 4.93 (br dd, 1 H), 3.30-3.79 (m, 1 H), 2.66-3.17 (m, 2 H) 448.1 [M+H] + 100%
1333 (CD 3OD) δ 9.36 (d, 1 H), 8.65-8.84 (m, 2 H), 8.21-8.42 (m, 1 H), 7.64 (br s, 1 H), 6.84-7.45 (m, 2 H), 6.60-6.83 (m, 2 H), 4.87-5.03 (m, 1 H), 3.31-3.77 (m, 1 H), 2.66-3.13 (m, 2 H) 448.1 [M+H] + 98.9%
1334 (CD 3OD) δ 8.63-8.67 (m, 1 H), 8.45-8.50 (m, 1 H), 7.47-7.72 (m, 3 H), 7.14-7.22 (m, 1 H), 6.96-7.08 (m, 2 H), 6.81 (s, 0.6 H), 6.66 (s, 0.4 H), 5.12 (dd, 0.5 H), 4.96 (br dd, 0.5 H), 3.88-3.99 (m, 0.6 H), 3.41 (td, 0.4 H), 2.83-3.26 (m, 5 H) 461.1 [M+H] + 100%
1335 (CD 3OD) δ 8.63-8.67 (m, 1 H), 8.47 (br d, 1 H), 7.48-7.73 (m, 3 H), 7.13-7.22 (m, 1 H), 6.95-7.08 (m, 2 H), 6.81 (s, 0.6 H), 6.66 (s, 0.4 H), 5.12 (br dd, 0.5 H), 4.93-4.99 (m, 0.5 H), 3.89-3.98 (m, 0.6 H), 3.36-3.45 (m, 0.4 H), 2.83-3.27 (m, 5 H) 461.2 [M+H] + 99.6%
1336 (CD 3OD) δ 9.03 (t, 2 H), 7.62-7.77 (m, 2 H), 7.37-7.54 (m, 1.5 H), 6.99-7.15 (m, 1.5 H), 6.39-6.76 (m, 2 H), 4.95 (br d, 1 H), 3.79-4.08 (m, 0.8 H), 3.36-3.42 (m, 0.2 H), 2.94-3.26 (m, 1 H), 2.78-2.92 (m, 1 H), 2.42-2.70 (m, 3 H) 428.2 [M+H] + 100%
1337 (CD 3OD) δ 9.03 (t, 2 H), 7.64-7.77 (m, 2 H), 7.36-7.55 (m, 1.5 H), 6.99-7.15 (m, 1.5 H), 6.42-6.74 (m, 2 H), 4.95 (br d, 1 H), 3.80-4.01 (m, 0.8 H), 3.37-3.43 (m, 0.2 H), 2.96-3.26 (m, 1 H), 2.82-2.92 (m, 1 H), 2.43-2.70 (m, 3 H) 428.2 [M+H] + 96.5%
1338 (CD 3OD) δ 9.36 (dd, 1 H), 8.65-8.85 (m, 2 H), 7.60 (d, 1 H), 6.83-7.45 (m, 3 H), 6.29-6.70 (m, 2 H), 4.89 (td, 1 H), 3.74-3.92 (m, 0.5 H), 3.24-3.38 (m, 0.5 H), 2.84-3.16 (m, 1 H), 2.69-2.82 (m, 1 H), 2.32-2.66 (m, 3 H) 428.1 [M+H] + 100%
1339 (CD 3OD) δ 9.36 (dd, 1 H), 8.68-8.81 (m, 2 H), 7.59 (d, 1 H), 6.83-7.43 (m, 3 H), 6.32-6.66 (m, 2 H), 4.84-4.95 (m, 1 H), 3.77-3.93 (m, 0.5 H), 3.24-3.37 (m, 0.5 H), 2.83-3.18 (m, 1 H), 2.70-2.83 (m, 1 H), 2.34-2.64 (m, 3 H) 428.1 [M+H] + 98.4%
1340 (CD 3OD) δ 9.31 (s, 1 H), 8.74-8.89 (m, 1 H), 8.34-8.63 (m, 1 H), 7.78-7.92 (m, 1 H), 7.65-7.76 (m, 2 H), 7.56 (br s, 0.5 H), 7.19-7.42 (m, 2 H), 6.80-7.05 (m, 1 H), 6.65 (s, 0.5 H), 4.93-5.16 (m, 1 H), 3.57-4.07 (m, 1 H), 2.96-3.25 (m, 1 H), 2.84-2.92 (m, 1 H) 481.1 [M+H] + 100%
1341 (CD 3OD) δ 9.30 (s, 1 H), 8.73-8.95 (m, 1 H), 8.44-8.66 (m, 1 H), 7.78-7.94 (m, 1 H), 7.62-7.77 (m, 2 H), 7.56 (br s, 0.5 H), 7.18-7.39 (m, 2 H), 6.83-7.05 (m, 1 H), 6.65 (s, 0.5 H), 4.92-5.16 (m, 1 H), 3.98 (br t, 1 H), 2.96-3.24 (m, 1 H), 2.87 (br d, 1 H) 481.1 [M+H] + 97.5%
1342 (CD 3OD) δ 8.64 (td, 1 H), 8.42-8.49 (m, 1 H), 7.79-7.89 (m, 1 H), 7.67-7.75 (m, 1 H), 7.45-7.60 (m, 1.5 H), 7.21-7.39 (m, 2 H), 6.84-7.00 (m, 1 H), 6.66 (s, 0.5 H), 5.12 (dd, 0.5 H), 4.96 (br dd, 0.5 H), 3.94-4.03 (m, 0.5 H), 3.34 (br d, 0.5 H), 2.85-3.29 (m, 5 H) 495.2 [M+H] + 100%
1343 (CD 3OD) δ 8.64 (br t, 1 H), 8.46 (br t, 1 H), 7.80-7.90 (m, 1 H), 7.66-7.77 (m, 1 H), 7.46-7.60 (m, 1.5 H), 7.21-7.38 (m, 2 H), 6.86-7.01 (m, 1 H), 6.67 (s, 0.5 H), 5.12 (br dd, 0.4 H), 4.96 (br dd, 0.6 H), 3.93-4.03 (m, 0.5 H), 3.32-3.36 (m, 0.5 H), 2.85-3.29 (m, 5 H) 495.2 [M+H] + 99.8%
1344 (CD 3OD) δ 8.46 (dd, 1 H), 8.27 (d, 1 H), 7.81-7.94 (m, 1 H), 7.68-7.76 (m, 1 H), 7.63 (ddd, 1.5 H), 7.35-7.40 (m, 0.5 H), 7.23-7.33 (m, 1.5 H), 7.00 (br s, 0.5 H), 6.89 (s, 0.5 H), 6.69 (s, 0.5 H), 4.97-5.10 (m, 1 H), 4.01 (d, 3.5 H), 3.39 (br d, 0.5 H), 3.14-3.27 (m, 0.5 H), 2.96-3.07 (m, 0.5 H), 2.82-2.94 (m, 1 H) 511.1 [M+H] + 96.1%
1345 (CD 3OD) δ 8.45 (dd, 1 H), 8.26 (d, 1 H), 7.81-7.93 (m, 1 H), 7.68-7.76 (m, 1 H), 7.58-7.66 (m, 1.5 H), 7.35-7.40 (m, 0.5 H), 7.22-7.34 (m, 1.5 H), 7.00 (s, 0.5 H), 6.67-6.90 (m, 1 H), 4.96-5.10 (m, 1 H), 4.01 (d, 3.5 H), 3.37-3.45 (m, 0.5 H), 3.12-3.26 (m, 0.5 H), 2.95-3.10 (m, 0.5 H), 2.82-2.95 (m, 1 H) 511.1 [M+H] + 92.3%
1346 (CD 3OD) δ 9.30 (s, 1 H), 8.80 (d, 1 H), 8.32-8.61 (m, 2 H), 7.54-7.74 (m, 3.3 H), 7.13-7.27 (m, 1 H), 6.80-7.03 (m, 1.7 H), 6.54-6.71 (m, 1 H), 4.91-5.11 (m, 1 H), 3.37-3.85 (m, 1 H), 2.82-3.25 (m, 2 H) 413.2 [M+H] + 100%
1347 (CD 3OD) δ 9.30 (s, 1 H), 8.80 (dd, 1 H), 8.34-8.62 (m, 2 H), 7.54-7.72 (m, 3.3 H), 7.12-7.27 (m, 1 H), 6.78-7.03 (m, 1.7 H), 6.49-6.69 (m, 1 H), 5.06 (br dd, 0.5 H), 4.93 (br d, 0.5 H), 3.72-3.87 (m, 0.7 H), 3.43 (td, 0.3 H), 2.81-3.24 (m, 2 H) 413.1 [M+H] + 100%
1348 1H NMR(甲醇- d 4) δ 8.51-8.62 (m, 1 H), 7.94-8.03 (m, 1 H), 7.70 (s, 1 H), 7.58 (s, 0.2 H), 7.37-7.50 (m, 1 H), 6.71-7.16 (m, 3.8 H), 5.10 (br dd, 0.5 H), 4.93 (br d, 0.5 H), 3.88 (s, 3 H), 3.70-3.83 (m, 0.5 H), 3.37-3.42 (m, 0.5 H), 2.78-3.25 (m, 2 H), 2.61-2.71 (m, 3 H) 480.2 [M+H] + 100%
1349 (CD 3OD) δ 8.46-8.65 (m, 1 H), 7.92-8.07 (m, 1 H), 7.70 (s, 1 H), 7.58 (s, 0.2 H), 7.33-7.50 (m, 1 H), 6.66-7.15 (m, 3.8 H), 5.10 (br dd, 0.5 H), 4.93 (br d, 0.5 H), 3.88 (s, 3 H), 3.68-3.81 (m, 0.5 H), 3.37-3.45 (m, 0.5 H), 2.78-3.26 (m, 2 H), 2.60-2.76 (m, 3 H) 480.2 [M+H] + 100%
1350 (CD 3OD) δ 8.47-8.64 (m, 1 H), 7.70 (s, 1 H), 7.39-7.49 (m, 1.3H), 6.67-7.15 (m, 3.7 H), 4.92-5.00 (m, 1 H), 3.68-3.82 (m, 0.5 H), 3.34-3.43 (m, 0.5 H), 2.77-3.21 (m, 2 H), 1.79-1.97 (m, 6 H) 446.2 [M+H] + 96.2%
1351 (CD 3OD) δ 8.49-8.64 (m, 1 H), 7.70 (s, 1 H), 7.38-7.48 (m, 1.3 H), 6.67-7.15 (m, 3.7 H), 4.92-5.01 (m, 1 H), 3.67-3.83 (m, 0.5 H), 3.35-3.43 (m, 0.5 H), 2.80-3.20 (m, 2 H), 1.81-1.95 (m, 6 H) 446.2 [M+H] + 91.3%
1352 (CD 3OD) δ 8.43-8.63 (m, 1 H), 7.64-7.85 (m, 2 H), 7.36-7.59 (m, 1.3 H), 6.71-7.15 (m, 4.7 H), 4.92-5.09 (m, 1 H), 4.02 (s, 3 H), 3.67-3.86 (m, 0.5 H), 3.39 (td, 0.5 H), 2.76-3.26 (m, 2 H) 466.2 [M+H] + 100%
1353 (CD 3OD) δ 8.59 (br s, 1 H), 7.80 (br s, 2 H), 7.38-7.56 (m, 1 H), 6.74-7.14 (m, 5 H), 5.03 (br d, 1 H), 4.02 (d, 3 H), 3.77 (br t, 0.5 H), 3.39 (br s, 0.5 H), 2.79-3.25 (m, 2 H) 466.2 [M+H] + 100%
1354 (CD 3OD) δ 7.86 (dd, 1 H), 7.64-7.76 (m, 1 H), 7.52 (br s, 0.5 H), 7.25-7.41 (m, 2 H), 6.83-7.01 (m, 1 H), 6.66 (s, 0.5 H), 4.99-5.04 (m, 1 H), 3.59-4.01 (m, 1 H), 2.80-3.19 (m, 2 H), 1.61 (s, 3 H), 1.38-1.46 (m, 2 H), 1.06-1.16 (m, 2 H) 458.1 [M+H] + 100%
1355 (CD 3OD) δ 7.74 (dd, 1 H), 7.52-7.63 (m, 1 H), 7.41 (br s, 0.5 H), 7.11-7.27 (m, 2 H), 6.70-6.85 (m, 1 H), 6.53 (s, 0.5 H), 4.81-4.94 (m, 1 H), 3.24-3.88 (m, 1 H), 2.68-3.05 (m, 2 H), 1.48 (s, 3 H), 1.26-1.33 (m, 2 H), 0.95-1.03 (m, 2 H) 458.2 [M+H] + 98.8%
1356 (CD 3OD) δ 8.61-8.66 (m, 1 H), 8.37-8.47 (m, 2 H), 7.71 (s, 1 H), 7.45-7.54 (m, 1.4 H), 7.25-7.32 (m, 1 H), 6.96 (s, 0.6 H), 6.72-6.87 (m, 2 H), 5.10 (dd, 0.6 H), 4.94 (br d, 0.4 H), 3.74-3.84 (m, 0.6 H), 3.43 (td, 0.3 H), 3.14-3.26 (m, 0.7 H), 2.92-3.06 (m, 3 H), 2.80-2.90 (m, 1 H) 461.1 [M+H] + 100%
1357 (CD 3OD) δ 8.64 (br d, 1 H), 8.37-8.47 (m, 2 H), 7.70 (br s, 1 H), 7.45-7.55 (m, 1 H), 7.26-7.32 (m, 1 H), 6.96 (br s, 1 H), 6.72-6.87 (m, 2 H), 5.10 (br dd, 0.6 H), 4.93 (br dd, 0.4 H), 3.75-3.84 (m, 0.6 H), 3.43 (td, 0.4 H), 2.80-3.26 (m, 5 H) 461.1 [M+H] + 99.7%
1358 (CD 3OD) δ 8.60-8.65 (m, 1 H), 8.38-8.45 (m, 1 H), 7.70 (d, 1 H), 7.39-7.51 (m, 2 H), 6.95-7.14 (m, 2 H), 6.60-6.72 (m, 1.6 H), 6.48 (s, 0.4 H), 5.08 (dd, 0.6 H), 4.94 (br s, 0.4 H), 3.88-3.98 (m, 0.6 H), 3.41 (td, 0.4 H), 3.13-3.24 (m, 0.5 H), 2.81-3.04 (m, 4.5 H), 2.65 (s, 1.8 H), 2.47 (s, 1.2 H) 441.2 [M+H] + 100%
1359 (CD 3OD) δ 8.63 (br d, 1 H), 8.43 (br s, 1 H), 7.73 (br s, 1 H), 7.39-7.52 (m, 2 H), 6.96-7.16 (m, 2 H), 6.60-6.75 (m, 1.6 H), 6.49 (s, 0.4 H), 5.09 (br dd, 1 H), 3.88-3.98 (m, 0.6 H), 3.41 (br t, 0.4 H), 3.14-3.25 (m, 0.6 H), 2.81-3.05 (m, 4.4 H), 2.66 (br s, 1.8 H), 2.48 (br s, 1.2 H) 441.2 [M+H] + 99.4%
1360 (CD 3OD) δ 9.35 (s, 1 H), 8.69-8.83 (m, 2 H), 7.69-7.83 (m, 1 H), 7.54-7.66 (m, 1 H), 7.23-7.50 (m, 1 H), 6.84-7.23 (m, 2 H), 6.54-6.81 (m, 1 H), 4.86-4.99 (m, 1 H), 3.82-3.95 (m, 0.5 H), 3.25-3.33 (m, 0.5 H), 2.85-3.16 (m, 1 H), 2.71-2.82 (m, 1 H) 482.1 [M+H] + 100%
1361 (CD 3OD) δ 9.35 (s, 1 H), 8.65-8.83 (m, 2 H), 7.67-7.86 (m, 1 H), 7.53-7.67 (m, 1 H), 7.24-7.51 (m, 1 H), 6.84-7.23 (m, 2 H), 6.49-6.84 (m, 1 H), 4.89-5.00 (m, 1 H), 3.82-3.95 (m, 0.5 H), 3.24-3.32 (m, 0.5 H), 2.86-3.15 (m, 1 H), 2.70-2.84 (m, 1 H) 482.1 [M+H] + 98.6%
1362 (CD 3OD) δ 9.30-9.42 (m, 1 H), 8.74 (br d, 2 H), 8.24-8.41 (m, 1 H), 7.60 (br s, 1 H), 6.83-7.54 (m, 3 H), 6.67-6.83 (m, 1 H), 6.46-6.61 (m, 1 H), 4.90 (br dd, 1 H), 3.62-3.76 (m, 0.5 H), 3.33 (td, 0.5 H), 2.84-3.17 (m, 1 H), 2.76 (br d, 1 H) 414.2 [M+H] + 100%
1363 (CD 3OD) δ 9.33-9.44 (m, 1 H), 8.71-8.80 (m, 2 H), 8.26-8.39 (m, 1 H), 7.60-7.73 (m, 1 H), 6.85-7.54 (m, 3 H), 6.68-6.82 (m, 1 H), 6.47-6.62 (m, 1 H), 4.91 (br dd, 1 H), 3.62-3.76 (m, 0.5 H), 3.26-3.39 (m, 0.5 H), 2.86-3.16 (m, 1 H), 2.69-2.83 (m, 1 H) 414.2 [M+H] + 100%
1364 (CD 3OD) δ 8.63 (br d, 1 H), 8.37-8.48 (m, 2 H), 7.70 (br s, 1 H), 7.45-7.61 (m, 2.4 H), 7.13-7.23 (m, 1 H), 6.96 (s, 0.6 H), 6.80-6.88 (m, 1 H), 6.57-6.65 (m, 1 H), 5.07 (br dd, 1 H), 3.75-3.84 (m, 0.7 H), 3.42 (td, 0.3 H), 3.15-3.24 (m, 0.6 H), 2.82-3.04 (m, 4.4 H) 427.1 [M+H] + 100%
1365 (CD 3OD) δ 8.64 (dd, 1 H), 8.38-8.48 (m, 2 H), 7.70 (br s, 1 H), 7.47-7.62 (m, 2.4 H), 7.15-7.23 (m, 1 H), 6.97 (s, 0.6 H), 6.81-6.89 (m, 1 H), 6.59-6.66 (m, 1 H), 5.07 (dd, 0.6 H), 4.93 (br d, 0.4 H), 3.75-3.85 (m, 0.7 H), 3.43 (td, 0.3 H), 3.15-3.25 (m, 0.7 H), 2.83-3.06 (m, 4.3 H) 427.1 [M+H] + 99.7%
1366 (CD 3OD) δ 7.88 (s, 1 H), 7.54-7.67 (m, 2 H), 7.24-7.49 (m, 1 H), 6.83-7.20 (m, 3 H), 6.48-6.69 (m, 1 H), 4.81-5.03 (m, 1 H), 3.78 (d, 3.6 H), 3.24-3.30 (m, 0.4 H), 2.69-3.09 (m, 2 H), 2.56 (d, 3 H) 480.2 [M+H] + 100%
1367 (CD 3OD) δ 7.87 (s, 1 H), 7.54-7.67 (m, 2 H), 7.24-7.48 (m, 1 H), 6.84-7.20 (m, 3 H), 6.51-6.68 (m, 1 H), 4.81-5.04 (m, 1 H), 3.78 (d, 3.6 H), 3.25-3.31 (m, 0.4 H), 2.70-3.12 (m, 2 H), 2.56 (d, 3 H) 480.1 [M+H] + 99.2%
1368 (CD 3OD) δ 8.43-8.57 (m, 1 H), 7.69 (s, 1 H), 7.29 (d, 1 H), 6.73-7.03 (m, 4 H), 6.28-6.64 (m, 1 H), 4.05-4.12 (m, 1 H), 3.95 (s, 3 H), 3.66-3.77 (m, 0.6 H), 3.20-3.28 (m, 0.3 H), 2.94-3.03 (m, 1 H), 2.72-2.82 (m, 1 H) 432.1 [M+H] + 100%
1369 (CD 3OD) δ 8.42-8.55 (m, 1 H), 7.69 (s, 1 H), 7.29 (d, 1 H), 6.73-7.05 (m, 4 H), 6.32-6.64 (m, 1 H), 4.04-4.14 (m, 1 H), 3.95 (s, 3 H), 3.72 (br t, 0.6 H), 3.25 (br t, 0.4 H), 2.93-3.04 (m, 1 H), 2.71-2.83 (m, 1 H) 432.1 [M+H] + 100%
1370 (CD 3OD) δ 8.68-8.83 (m, 1 H), 7.60-7.71 (m, 2 H), 6.74-7.06 (m, 4 H), 6.31-6.65 (m, 1 H), 4.06-4.13 (m, 1 H), 3.96 (s, 3 H), 3.67-3.76 (m, 0.6 H), 3.19-3.25 (m, 0.4 H), 2.93-3.05 (m, 1 H), 2.70-2.84 (m, 1 H) 466.1 [M+H] + 99.8%
1371 (CD 3OD) δ 8.67-8.82 (m, 1 H), 7.58-7.73 (m, 2 H), 6.72-7.05 (m, 4 H), 6.31-6.65 (m, 1 H), 4.09 (br d, 1 H), 3.96 (s, 3 H), 3.66-3.78 (m, 0.6 H), 3.25 (br d, 0.4 H), 2.99 (br t, 1 H), 2.72-2.85 (m, 1 H) 466.2 [M+H] + 99.4%
1372 (CD 3OD) δ 8.55-8.71 (m, 1 H), 7.69 (s, 1 H), 7.43 (br d, 1 H), 6.72-7.14 (m, 5 H), 6.32-6.66 (m, 1 H), 4.04-4.14 (m, 1 H), 3.95 (s, 3 H), 3.65-3.78 (m, 0.6 H), 3.17-3.27 (m, 0.4 H), 2.92-3.05 (m, 1 H), 2.70-2.83 (m, 1 H) 448.2 [M+H] + 99.7%
1373 (CD 3OD) δ 8.57-8.71 (m, 1 H), 7.69 (s, 1 H), 7.43 (br d, 1 H), 6.73-7.14 (m, 5 H), 6.31-6.63 (m, 1 H), 4.04-4.14 (m, 1 H), 3.95 (s, 3 H), 3.65-3.78 (m, 0.6 H), 3.20-3.27 (m, 0.4 H), 2.93-3.05 (m, 1 H), 2.77 (br t, 1 H) 448.2 [M+H] + 99.0%
1374 (CD 3OD) δ 8.91 (br s, 1 H), 8.47-8.66 (m, 1 H), 8.34 (s, 1 H), 7.56-7.82 (m, 2 H), 7.37-7.52 (m, 1 H), 6.72-7.14 (m, 4 H), 5.08 (br dd, 1 H), 3.77 (br t, 0.5 H), 3.36-3.47 (m, 0.5 H), 2.76-3.25 (m, 2 H) 502.2 [M+H] + 100%
1375 (CD 3OD) δ 8.88-8.96 (m, 1 H), 8.51-8.63 (m, 1 H), 8.35 (s, 1 H), 7.55-7.84 (m, 2 H), 7.38-7.52 (m, 1 H), 6.74-7.16 (m, 4 H), 5.10 (br dd, 1 H), 3.71-3.88 (m, 0.5 H), 3.42 (td, 0.5 H), 2.79-3.26 (m, 2 H) 502.2 [M+H] + 100%
1376 (CD 3OD) δ 8.48-8.61 (m, 1 H), 8.33 (d, 1 H), 7.82 (s, 0.3 H), 7.64-7.76 (m, 1.5 H), 7.53 (d, 0.5 H), 7.38-7.47 (m, 1 H), 7.21 (d, 1 H), 6.75-7.13 (m, 3.7 H), 4.94-5.10 (m, 1 H), 3.73-3.83 (m, 0.5 H), 3.35-3.46 (m, 0.5 H), 2.80-3.26 (m, 2 H) 502.2 [M+H] + 100%
1377 (CD 3OD) δ 8.49-8.61 (m, 1 H), 8.33 (d, 1 H), 7.82 (s, 0.3 H), 7.69 (br d, 1.5 H), 7.53 (d, 0.5 H), 7.37-7.47 (m, 1 H), 7.21 (d, 1 H), 6.73-7.15 (m, 3.7 H), 4.92-5.11 (m, 1 H), 3.71-3.86 (m, 0.5 H), 3.35-3.50 (m, 0.5 H), 2.79-3.26 (m, 2 H) 502.2 [M+H] + 99.3%
1378 (CD 3OD) δ 8.29-8.39 (m, 1 H), 7.70 (s, 1 H), 7.45 (s, 0.3 H), 6.65-7.02 (m, 3.7 H), 5.01 (dd, 1 H), 3.74 (ddd, 0.7 H), 3.37-3.46 (m, 0.3 H), 2.80-3.18 (m, 2 H), 1.58-1.63 (m, 3 H), 1.39-1.47 (m, 2 H), 1.08-1.14 (m, 2 H) 408.2 [M+H] + 100%
1379 (CD 3OD) δ 8.30-8.39 (m, 1 H), 7.70 (s, 1 H), 7.45 (s, 0.3 H), 6.68-7.02 (m, 3.7 H), 5.01 (dd, 1 H), 3.64-3.81 (m, 0.7 H), 3.36-3.44 (m, 0.3 H), 2.79-3.18 (m, 2 H), 1.61 (s, 3 H), 1.39-1.47 (m, 2 H), 1.05-1.16 (m, 2 H) 408.1 [M+H] + 99.6%
1380 (CD 3OD) δ 9.03 (d, 2 H), 8.71 (d, 1 H), 7.44-7.74 (m, 3.5 H), 6.81-7.01 (m, 2.5 H), 4.92-5.04 (m, 1 H), 3.80 (ddd, 0.7 H), 3.44 (td, 0.3 H), 3.17-3.27 (m, 0.7 H), 3.00-3.07 (m, 0.3 H), 2.78-2.94 (m, 1 H) 482.1 [M+H] + 100%
1381 (CD 3OD) δ 9.03 (d, 2 H), 8.71 (d, 1 H), 7.43-7.79 (m, 3.5 H), 6.81-7.01 (m, 2.5 H), 4.92-5.06 (m, 1 H), 3.74-3.85 (m, 0.7 H), 3.41-3.49 (m, 0.3 H), 2.98-3.28 (m, 1 H), 2.86 (br d, 1 H) 482.2 [M+H] + 93.5%
1382 (CD 3OD) δ 8.37-8.52 (m, 1 H), 8.07-8.16 (m, 1 H), 7.95 (t, 1 H), 7.78-7.88 (m, 1 H), 6.98-7.68 (m, 4 H), 6.82-6.92 (m, 1 H), 6.60-6.74 (m, 1 H), 4.93-5.10 (m, 1 H), 3.75-3.87 (m, 0.5 H), 3.36-3.52 (m, 0.5 H), 2.98-3.29 (m, 1 H), 2.80-2.92 (m, 1 H), 2.66 (s, 3 H) 427.2 [M+H] + 100%
1383 (CD 3OD) δ 8.38-8.53 (m, 1 H), 8.04-8.16 (m, 1 H), 7.95 (t, 1 H), 7.72 (s, 1 H), 6.95-7.67 (m, 4 H), 6.80-6.96 (m, 1 H), 6.55-6.74 (m, 1 H), 5.02 (dd, 1 H), 3.74-3.92 (m, 0.5 H), 3.38-3.52 (m, 0.5 H), 2.93-3.29 (m, 1 H), 2.76-2.92 (m, 1 H), 2.66 (s, 3 H) 427.2 [M+H] + 100%
1384 (CD 3OD) δ 7.75-7.98 (m, 1 H), 7.62 (br s, 1 H), 6.97-7.39 (m, 3 H), 6.60-6.97 (m, 2 H), 6.33-6.53 (m, 1 H), 4.75 (s, 0.5 H), 4.08 (br s, 0.5 H), 4.02 (s, 3 H), 3.70-3.87 (m, 0.5 H), 3.15 (s, 0.5 H), 2.95-3.08 (m, 1 H), 2.81 (br d, 1 H) 432.1 [M+H] + 99.9%
1385 (CD 3OD) δ 7.70 (s, 1 H), 7.61 (br s, 1 H), 6.95-7.37 (m, 3 H), 6.61-6.95 (m, 2 H), 6.33-6.51 (m, 1 H), 4.85 (br d, 0.5 H), 4.06-4.12 (m, 0.5 H), 4.02 (br d, 3 H), 3.79 (br s, 0.5 H), 3.28 (br s, 0.5 H), 3.00 (br d, 1 H), 2.68-2.87 (m, 1 H) 432.1 [M+H] + 99.6%
1386 (CD 3OD) δ 7.87 (br d, 1 H), 7.71 (br d, 1 H), 6.95-7.53 (m, 3 H), 6.59-6.95 (m, 2 H), 6.29-6.59 (m, 1 H), 4.82 (br d, 0.5 H), 4.07 (br d, 0.5 H), 3.97 (br d, 3 H), 3.78 (br t, 0.5 H), 3.18-3.30 (m, 0.5 H), 3.01 (br d, 1 H), 2.67-2.88 (m, 1 H) 466.1 [M+H] + 99.6%
1387 (CD 3OD) δ 7.88 (br d, 1 H), 7.70 (br s, 1 H), 6.95-7.54 (m, 3 H), 6.59-6.95 (m, 2 H), 6.27-6.58 (m, 1 H), 4.83 (br d, 0.5 H), 4.07 (br d, 0.5 H), 3.97 (br d, 3 H), 3.70-3.86 (m, 0.5 H), 3.29 (br s, 0.5 H), 3.01 (br d, 1 H), 2.66-2.87 (m, 1 H) 466.1 [M+H] + 98.2%
1388 (CD 3OD) δ 7.68 (br d, 1 H), 6.97-7.57 (m, 3 H), 6.58-6.97 (m, 3 H), 6.28-6.44 (m, 1 H), 4.76-4.86 (m, 0.5 H), 4.06 (br d, 0.5 H), 3.97 (br d, 3 H), 3.81 (br t, 0.5 H), 3.37 (br s, 0.5 H), 3.00 (br d, 1 H), 2.82 (br s, 1 H), 2.63-2.77 (m, 3 H) 412.2 [M+H] + 96.9%
1389 (CD 3OD) δ 7.68 (br d, 1 H), 6.96-7.56 (m, 3 H), 6.58-6.96 (m, 3 H), 6.26-6.43 (m, 1 H), 4.82 (br d, 0.5 H), 4.06 (br d, 0.5 H), 3.97 (br d, 3 H), 3.74-3.88 (m, 0.5 H), 3.35-3.42 (m, 0.5 H), 3.00 (br d, 1 H), 2.82 (br s, 1 H), 2.63-2.79 (m, 3 H) 412.2 [M+H] + 99.6%
1390 (CD 3OD) δ 7.66-7.80 (m, 2 H), 7.38-7.60 (m, 1 H), 7.14-7.34 (m, 2.5 H), 6.93 (s, 0.5 H), 6.60-6.79 (m, 1 H), 5.01 (dd, 1 H), 3.81-3.93 (m, 0.6 H), 3.35-3.39 (m, 0.4 H), 2.80-3.17 (m, 2 H), 2.28-2.38 (m, 1 H), 1.26-1.32 (m, 2 H), 1.20-1.25 (m, 2 H) 426.1 [M+H] + 100%
1391 (CD 3OD) δ 7.66-7.80 (m, 2 H), 7.52 (s, 1 H), 7.13-7.37 (m, 2.5 H), 6.93 (s, 0.5 H), 6.61-6.78 (m, 1 H), 5.01 (dd, 1 H), 3.79-3.92 (m, 0.6 H), 3.35-3.40 (m, 0.4 H), 2.81-3.18 (m, 2 H), 2.28-2.38 (m, 1 H), 1.26-1.32 (m, 2 H), 1.23 (br dd, 2 H) 426.2 [M+H] + 92.9%
1392 (CD 3OD) δ 8.84-9.11 (m, 2 H), 7.47-7.73 (m, 3 H), 6.94-7.36 (m, 3 H), 6.59-6.88 (m, 1 H), 4.99 (ddd, 1 H), 3.88-3.99 (m, 0.5 H), 3.34-3.46 (m, 0.5 H), 2.82-3.27 (m, 2 H) 448.1 [M+H] + 100%
1393 (CD 3OD) δ 9.03 (dd, 2 H), 7.52-7.76 (m, 3 H), 7.45-7.50 (m, 0.3 H), 6.96-7.21 (m, 2.7 H), 6.58-6.86 (m, 1 H), 4.94-5.05 (m, 1 H), 3.87-3.99 (m, 0.5 H), 3.34-3.44 (m, 0.5 H), 2.83-3.25 (m, 2 H) 448.1 [M+H] + 99.4%
1394 (CD 3OD) δ 8.51-8.68 (m, 2 H), 8.41-8.50 (m, 1 H), 7.70-7.77 (m, 1 H), 7.39-7.59 (m, 2.3 H), 6.77-7.16 (m, 3.7 H), 4.93-5.18 (m, 1 H), 3.72-3.86 (m, 0.5 H), 3.42 (td, 0.5 H), 3.18-3.26 (m, 0.5 H), 2.83-3.06 (m, 4.5 H) 477.2 [M+H] + 100%
1395 (CD 3OD) δ 8.51-8.70 (m, 2 H), 8.37-8.50 (m, 1 H), 7.74 (br s, 1 H), 7.37-7.59 (m, 2.5 H), 6.75-7.16 (m, 3.5 H), 4.93-5.17 (m, 1 H), 3.72-3.88 (m, 0.5 H), 3.37-3.51 (m, 0.5 H), 3.18-3.26 (m, 0.5 H), 2.82-3.06 (m, 4.5 H) 477.2 [M+H] + 99.5%
1396 (CD 3OD) δ 8.07-8.17 (m, 1 H), 7.95 (t, 1 H), 7.72 (d, 1 H), 7.58-7.69 (m, 1 H), 7.03-7.58 (m, 3 H), 6.96-7.03 (m, 1 H), 6.62-6.87 (m, 1 H), 4.93-5.12 (m, 1 H), 3.88-4.01 (m, 0.5 H), 3.41 (td, 0.5 H), 2.95-3.28 (m, 1 H), 2.79-2.94 (m, 1 H), 2.66 (s, 3 H) 461.1 [M+H] + 100%
1397 (CD 3OD) δ 8.08-8.19 (m, 1 H), 7.95 (td, 1 H), 7.72 (d, 1 H), 7.57-7.68 (m, 1 H), 7.04-7.57 (m, 3 H), 6.95-7.04 (m, 1 H), 6.60-6.88 (m, 1 H), 4.95-5.09 (m, 1 H), 3.88-4.01 (m, 0.5 H), 3.38-3.47 (m, 0.5 H), 2.96-3.30 (m, 1 H), 2.82-2.96 (m, 1 H), 2.66 (d, 3 H) 461.1 [M+H] + 98.3%
1398 (CD 3OD) δ 8.11 (dd, 1 H), 7.95 (td, 1 H), 7.71 (d, 1 H), 6.97-7.61 (m, 4 H), 6.65-6.77 (m, 1 H), 6.43-6.65 (m, 1 H), 4.94-5.09 (m, 1 H), 3.89-4.02 (m, 0.5 H), 3.36-3.44 (m, 0.5 H), 2.96-3.28 (m, 1 H), 2.80-2.96 (m, 1 H), 2.45-2.74 (m, 6 H) 441.2 [M+H] + 100%
1399 (CD 3OD) δ 8.11 (dd, 1 H), 7.95 (td, 1 H), 7.71 (d, 1 H), 6.98-7.58 (m, 4 H), 6.66-6.77 (m, 1 H), 6.44-6.66 (m, 1 H), 5.00 (td, 1 H), 3.88-4.02 (m, 0.5 H), 3.36-3.44 (m, 0.5 H), 2.94-3.26 (m, 1 H), 2.81-2.94 (m, 1 H), 2.45-2.76 (m, 6 H) 441.2 [M+H] + 99.6%
1400 (CD 3OD) δ 7.98 (d, 1 H), 7.68-7.88 (m, 2 H), 7.53-7.66 (m, 1 H), 7.22-7.51 (m, 2 H), 6.83-7.22 (m, 2 H), 6.53-6.81 (m, 1 H), 4.83-4.99 (m, 1 H), 3.82-3.94 (m, 0.5 H), 3.24-3.31 (m, 0.5 H), 2.84-3.16 (m, 1 H), 2.71-2.84 (m, 1 H), 2.54 (d, 3 H) 495.1 [M+H] + 100%
1401 (CD 3OD) δ 7.99 (d, 1 H), 7.67-7.88 (m, 2 H), 7.53-7.67 (m, 1 H), 7.23-7.51 (m, 2 H), 6.82-7.23 (m, 2 H), 6.52-6.82 (m, 1 H), 4.83-5.00 (m, 1 H), 3.87 (br t, 0.5 H), 3.24-3.32 (m, 0.5 H), 2.85-3.16 (m, 1 H), 2.68-2.85 (m, 1 H), 2.54 (d, 3 H) 495.1 [M+H] + 88.1%
1402 (CD 3OD) δ 7.76 (br d, 1 H), 7.69 (br d, 1 H), 7.29-7.63 (m, 2 H), 6.94-7.29 (m, 2 H), 6.61-6.94 (m, 2 H), 6.25-6.52 (m, 1 H), 4.83 (br s, 1 H), 4.07 (br d, 0.5 H), 3.96 (br d, 3 H), 3.69-3.86 (m, 0.5 H), 3.00 (br d, 1 H), 2.64-2.90 (m, 1 H) 448.2 [M+H] + 99.9%
1403 (CD 3OD) δ 7.76 (br d, 1 H), 7.70 (br d, 1 H), 7.29-7.59 (m, 2 H), 6.94-7.29 (m, 2 H), 6.61-6.94 (m, 2 H), 6.27-6.53 (m, 1 H), 4.83 (br s, 1 H), 4.07 (br d, 0.5 H), 3.96 (br d, 3 H), 3.78 (br t, 0.5 H), 3.00 (br d, 1 H), 2.69-2.87 (m, 1 H) 448.2 [M+H] + 98.2%
1404 (CD 3OD) δ 8.35 (d, 1 H), 7.43-7.88 (m, 3.5 H), 7.19-7.36 (m, 2 H), 6.99 (s, 0.5 H), 6.72-6.88 (m, 1 H), 6.60-6.71 (m, 1 H), 5.08 (br dd, 0.7 H), 4.96-4.98 (m, 0.3 H), 3.78-3.93 (m, 0.5 H), 3.40-3.53 (m, 0.5 H), 2.96-3.24 (m, 1 H), 2.87 (br d, 1 H) 470.1 [M+H] + 100%
1405 (CD 3OD) δ 8.36 (d, 1 H), 7.96-8.16 (m, 1 H), 7.43-7.89 (m, 2.5 H), 7.19-7.36 (m, 2 H), 7.06 (s, 0.5 H), 6.79-6.93 (m, 1 H), 6.58-6.75 (m, 1 H), 5.13 (br dd, 0.7 H), 4.95-4.97 (m, 0.3 H), 3.75-3.90 (m, 0.7 H), 3.41-3.54 (m, 0.3 H), 3.24 (br d, 0.8 H), 3.04 (br d, 0.2 H), 2.84-2.97 (m, 1 H) 470.1 [M+H] + 100%
1406 (CD 3OD) δ 8.40 (s, 1 H), 8.11 (s, 1 H), 7.66-7.80 (m, 2 H), 7.36-7.60 (m, 1 H), 6.97-7.34 (m, 3 H), 6.61-6.81 (m, 1 H), 4.95-5.15 (m, 1 H), 4.02 (d, 3 H), 3.82-3.97 (m, 0.6 H), 3.36-3.43 (m, 0.4 H), 2.83-3.24 (m, 2 H) 466.2 [M+H] + 100%
1407 (CD 3OD) δ 8.41 (s, 1 H), 8.11 (s, 1 H), 7.67-7.82 (m, 2 H), 7.36-7.61 (m, 1 H), 6.95-7.33 (m, 3 H), 6.61-6.83 (m, 1 H), 4.93-5.15 (m, 1 H), 4.02 (d, 3 H), 3.82-3.95 (m, 0.6 H), 3.36-3.44 (m, 0.4 H), 2.82-3.24 (m, 2 H) 466.2 [M+H] + 99.2%
1408 (CD 3OD) δ 8.45-8.65 (m, 1 H), 7.69 (s, 1 H), 7.43 (br t, 1.3 H), 6.65-7.17 (m, 3.7 H), 4.98 (br dd, 1 H), 3.63-3.83 (m, 0.5 H), 3.34-3.44 (m, 0.5 H), 2.73-3.22 (m, 2 H), 1.45-1.51 (m, 9 H) 442.1 [M+H] + 100
1409 (CD 3OD) δ 8.43-8.68 (m, 1 H), 7.69 (s, 1 H), 7.43 (br t, 1.3 H), 6.70-7.14 (m, 3.7 H), 4.98 (br dd, 1 H), 3.63-3.81 (m, 0.5 H), 3.34-3.43 (m, 0.5 H), 2.73-3.22 (m, 2 H), 1.43-1.58 (m, 9 H) 442.2 [M+H] + 99.1%
1410 (DMSO- d 6) δ 9.02-9.18 (m, 2 H), 8.56-8.81 (m, 1 H), 8.23 (s, 0.3 H), 7.74-7.85 (m, 1 H), 7.63 (s, 1 H), 7.36-7.49 (m, 1 H), 6.68-6.94 (m, 2.7 H), 4.70-4.92 (m, 1 H), 3.60-3.81 (m, 0.6 H), 2.98-3.09 (m, 1 H), 2.62-2.92 (m, 1.4 H) 448.1 [M+H] + 100%
1411 (DMSO- d 6) δ 8.99-9.17 (m, 2 H), 8.61-8.72 (m, 0.8 H), 8.23 (s, 0.2 H), 7.36-7.87 (m, 3 H), 7.19 (br d, 0.3 H), 6.67-6.95 (m, 2.7 H), 4.85 (br dd, 1 H), 3.66-3.75 (m, 0.5 H), 2.97-3.10 (m, 1 H), 2.73-2.94 (m, 1.5 H) 448.1 [M+H] + 97.3%
1412 (CD 3OD) δ 9.02 (d, 2 H), 8.49-8.62 (m, 1 H), 7.65-7.77 (m, 2 H), 7.38-7.51 (m, 1.3 H), 7.08-7.15 (m, 0.2 H), 6.80-7.02 (m, 3.5 H), 4.94-5.03 (m, 1 H), 3.79 (ddd, 0.5 H), 3.37-3.49 (m, 0.5 H), 2.83-3.25 (m, 2 H) 464.1 [M+H] + 100%
1413 (CD 3OD) δ 9.03 (d, 2 H), 8.51-8.62 (m, 1 H), 7.64-7.75 (m, 2 H), 7.39-7.49 (m, 1.3 H), 7.09-7.15 (m, 0.2 H), 6.81-7.00 (m, 3.5 H), 4.92-5.04 (m, 1 H), 3.73-3.87 (m, 0.5 H), 3.43 (td, 0.5 H), 2.83-3.26 (m, 2 H) 464.2 [M+H] + 95.7%
1414 (CD 3OD) δ 9.46 (s, 1 H), 8.80-8.89 (m, 2 H), 8.50-8.64 (m, 1 H), 7.71 (s, 1 H), 7.39-7.52 (m, 1.4 H), 7.09-7.14 (m, 0.2 H), 6.80-7.00 (m, 3.4 H), 4.94-5.10 (m, 1 H), 3.72-3.89 (m, 0.5 H), 3.43 (td, 0.5 H), 2.83-3.24 (m, 2 H) 464.2 [M+H] + 100%
1415 (CD 3OD) δ 9.41-9.53 (m, 1 H), 8.80-8.90 (m, 2 H), 8.50-8.66 (m, 1 H), 7.74 (br s, 1 H), 7.40-7.52 (m, 1.4 H), 7.09-7.14 (m, 0.2 H), 6.81-7.00 (m, 3.4 H), 5.03 (br dd, 1 H), 3.70-3.87 (m, 0.5 H), 3.37-3.50 (m, 0.5 H), 2.85-3.24 (m, 2 H) 464.2 [M+H] + 94.7%
1416 (CD 3OD) δ 9.27 (s, 1 H), 8.37-8.92 (m, 3 H), 7.88-8.11 (m, 4 H), 7.55-7.68 (m, 2 H), 7.12-7.43 (m, 2 H), 6.39-6.99 (m, 3 H), 4.49-4.75 (m, 1 H), 3.38-3.86 (m, 1 H), 3.01-3.14 (m, 1 H), 2.77 (br dd, 1 H) 461.2 [M+H] + 100%
1417 (CD 3OD) δ 9.20-9.35 (m, 1 H), 8.24-8.97 (m, 3 H), 7.86-8.13 (m, 4 H), 7.54-7.72 (m, 2 H), 7.33-7.44 (m, 1 H), 7.13-7.26 (m, 1 H), 6.35-7.03 (m, 3 H), 4.43-4.79 (m, 1 H), 3.38-3.97 (m, 1 H), 3.02-3.16 (m, 1 H), 2.78 (br d, 1 H) 461.2 [M+H] + 100%
1418 (CD 3OD) δ 7.67-7.80 (m, 2 H), 7.44 (d, 1 H), 6.94-7.32 (m, 3 H), 6.60-6.80 (m, 1 H), 4.93-5.03 (m, 1 H), 3.81-3.93 (m, 0.6 H), 3.36-3.42 (m, 0.4 H), 2.82-3.19 (m, 2 H), 1.49 (d, 9 H) 442.2 [M+H] + 100%
1419 (CD 3OD) δ 7.55-7.69 (m, 2 H), 7.29-7.47 (m, 1 H), 6.82-7.21 (m, 3 H), 6.48-6.69 (m, 1 H), 4.82-4.91 (m, 1 H), 3.69-3.83 (m, 0.6 H), 3.24-3.28 (m, 0.4 H), 2.70-3.07 (m, 2 H), 1.37 (d, 9 H) 442.2 [M+H] + 99.1%
1420 (CD 3OD) δ 8.61-8.71 (m, 1 H), 8.15-8.26 (m, 1 H), 7.98 (tt, 1 H), 7.53-7.67 (m, 3 H), 7.25-7.48 (m, 1 H), 6.87-7.21 (m, 3 H), 6.50-6.70 (m, 1 H), 4.83-4.95 (m, 1 H), 3.77-3.87 (m, 0.6 H), 3.24-3.30 (m, 0.4 H), 2.73-3.15 (m, 2 H) 463.1 [M+H] + 100%
1421 (CD 3OD) δ 8.61-8.75 (m, 1 H), 8.12-8.29 (m, 1 H), 7.98 (tt, 1 H), 7.53-7.69 (m, 3 H), 7.26-7.49 (m, 1 H), 6.87-7.21 (m, 3 H), 6.48-6.72 (m, 1 H), 4.81-4.93 (m, 1 H), 3.76-3.87 (m, 0.6 H), 3.24-3.30 (m, 0.4 H), 2.72-3.14 (m, 2 H) 463.1 [M+H] + 100%
1422 (CD 3OD) δ 9.32 (s, 1 H), 8.80 (br d, 1 H), 8.50-8.65 (m, 2 H), 7.64-7.77 (m, 2 H), 7.42-7.58 (m, 1.2 H), 6.91-7.17 (m, 2.6 H), 6.77-6.87 (m, 1.2 H), 5.10 (br d, 1 H), 3.79 (br t, 0.5 H), 3.42 (br s, 0.5 H), 2.78-3.23 (m, 2 H) 463.2 [M+H] + 100%
1423 (CD 3OD) δ 9.31 (br s, 1 H), 8.80 (br d, 1 H), 8.47-8.66 (m, 2 H), 7.64-7.76 (m, 2 H), 7.44 (br d, 1.2 H), 6.90-7.16 (m, 3.6 H), 6.76-6.87 (m, 1.2 H), 5.10 (br d, 1 H), 3.72-3.89 (m, 0.5 H), 3.43 (br s, 0.5 H), 2.81-3.24 (m, 2 H) 463.2 [M+H] + 97.7%
1424 (CD 3OD) δ 8.52-8.64 (m, 1 H), 8.45 (d, 1 H), 8.26 (d, 1 H), 7.73 (br s, 1 H), 7.62 (dd, 1 H), 7.40-7.57 (m, 1.3 H), 6.78-7.16 (m, 3.7 H), 4.95-5.10 (m, 1 H), 4.00 (s, 3 H), 3.72-3.87 (m, 0.5 H), 3.43 (td, 0.5 H), 2.75-3.28 (m, 2 H) 493.1 [M+H] + 100%
1425 (CD 3OD) δ 8.51-8.65 (m, 1 H), 8.44 (d, 1 H), 8.25 (d, 1 H), 7.73 (br s, 1 H), 7.52-7.64 (m, 1.3 H), 7.38-7.49 (m, 1 H), 6.78-7.16 (m, 3.7 H), 4.95-5.10 (m, 1 H), 4.00 (s, 3 H), 3.74-3.86 (m, 0.5 H), 3.39-3.48 (m, 0.5 H), 2.81-3.27 (m, 2 H) 493.2 [M+H] + 94.4%
1426 (CD 3OD) δ 8.40-8.63 (m, 2 H), 7.87 (t, 1 H), 7.58-7.75 (m, 2 H), 7.29-7.48 (m, 1.3 H), 6.68-7.14 (m, 3.7 H), 4.94 (br dd, 1 H), 3.68-3.81 (m, 0.5 H), 3.36-3.43 (m, 0.5 H), 2.77-3.22 (m, 2 H) 481.1 [M+H] + 100%
1427 (CD 3OD) δ 8.45-8.70 (m, 2 H), 7.93 (t, 1 H), 7.65-7.79 (m, 2 H), 7.36-7.51 (m, 1.3 H), 6.77-7.16 (m, 3.7 H), 4.94-5.04 (m, 1 H), 3.69-3.86 (m, 0.5 H), 3.42 (td, 0.5 H), 2.81-3.27 (m, 2 H) 481.2 [M+H] + 99.5%
1428 (CD 3OD) δ 8.23-8.38 (m, 1 H), 8.11 (br d, 1 H), 7.95 (br t, 1 H), 7.72 (s, 1 H), 7.54 (br d, 1.3 H), 6.94-7.08 (m, 1.7 H), 6.73-6.86 (m, 1 H), 6.54-6.72 (m, 1 H), 5.02 (br dd, 1 H), 3.82 (br t, 0.6 H), 3.39-3.51 (m, 0.4 H), 2.96-3.28 (m, 1 H), 2.87 (br d, 1 H), 2.66 (s, 3 H), 2.36-2.56 (m, 3 H) 441.1 [M+H] + 100%
1429 (CD 3OD) δ 8.24-8.37 (m, 1 H), 8.11 (br d, 1 H), 7.95 (t, 1 H), 7.73 (s, 1 H), 7.54 (d, 1.3 H), 6.95-7.05 (m, 1.7 H), 6.72-6.85 (m, 1 H), 6.57-6.70 (m, 1 H), 4.93-5.06 (m, 1 H), 3.78-3.87 (m, 0.6 H), 3.45 (td, 0.4H), 2.99-3.27 (m, 1 H), 2.81-2.94 (m, 1 H), 2.66 (s, 3 H), 2.40-2.52 (m, 3 H) 441.2 [M+H] + 99.3%
1430 (CD 3OD) δ 8.38-8.51 (m, 1 H), 8.11 (d, 1 H), 7.95 (t, 1 H), 7.75 (br s, 1 H), 7.54 (d, 1.3 H), 7.26-7.36 (m, 1 H), 7.00 (s, 0.7 H), 6.82-6.92 (m, 1 H), 6.71-6.82 (m, 1 H), 4.92-5.11 (m, 1 H), 3.75-3.87 (m, 0.6 H), 3.40-3.51 (m, 0.4 H), 2.98-3.28 (m, 1 H), 2.79-2.94 (m, 1 H), 2.66 (s, 3 H) 461.1 [M+H] + 100%
1431 (CD 3OD) δ 8.27-8.42 (m, 1 H), 7.99 (d, 1 H), 7.83 (t, 1 H), 7.66 (br s, 1 H), 7.42 (d, 1.3 H), 7.13-7.27 (m, 1 H), 6.88 (s, 0.7 H), 6.70-6.81 (m, 1 H), 6.60-6.70 (m, 1 H), 4.82-4.98 (m, 1 H), 3.62-3.76 (m, 0.6 H), 3.27-3.40 (m, 0.4 H), 2.84-3.16 (m, 1 H), 2.68-2.84 (m, 1 H), 2.54 (s, 3 H) 461.2 [M+H] + 98.7%
1432 (CD 3OD) δ 8.51-8.65 (m, 1 H), 8.00 (d, 1 H), 7.77-7.89 (m, 1 H), 7.62 (s, 1 H), 7.47-7.58 (m, 1 H), 7.36-7.47 (m, 1.3 H), 6.80-6.95 (m, 1.7 H), 6.62-6.76 (m, 1 H), 4.83-4.99 (m, 1 H), 3.63-3.75 (m, 0.6 H), 3.26-3.40 (m, 0.4 H), 2.86-3.16 (m, 1 H), 2.70-2.82 (m, 1 H), 2.50-2.58 (m, 3 H) 495.1 [M+H] + 100%
1433 (CD 3OD) δ 8.52-8.66 (m, 1 H), 7.99 (d, 1 H), 7.77-7.90 (m, 1 H), 7.60-7.70 (m, 1 H), 7.49-7.57 (m, 1 H), 7.38-7.46 (m, 1.3 H), 6.81-6.96 (m, 1.7 H), 6.64-6.77 (m, 1 H), 4.82-4.99 (m, 1 H), 3.62-3.75 (m, 0.6 H), 3.27-3.40 (m, 0.4 H), 2.85-3.17 (m, 1 H), 2.69-2.82 (m, 1 H), 2.43-2.60 (m, 3 H) 495.1 [M+H] + 96.5%
1434 (CD 3OD) δ 8.98 (s, 1 H), 8.23-8.78 (m, 2 H), 7.83-8.04 (m, 2 H), 7.56-7.70 (m, 3 H), 7.16-7.22 (m, 1 H), 6.35-6.95 (m, 4 H), 4.46-4.73 (m, 1 H), 3.95 (s, 3 H), 3.46-3.77 (m, 1 H), 3.01-3.15 (m, 1 H), 2.70-2.80 (m, 1 H) 464.2 [M+H] + 100%
1435 (CD 3OD) δ 8.97 (s, 1 H), 8.27-8.77 (m, 2 H), 7.85-8.02 (m, 2 H), 7.55-7.70 (m, 3 H), 7.15-7.22 (m, 1 H), 6.39-7.02 (m, 4 H), 4.47-4.71 (m, 1 H), 3.95 (s, 3 H), 3.36-3.80 (m, 1 H), 3.00-3.14 (m, 1 H), 2.71-2.81 (m, 1 H) 464.2 [M+H] + 99.8%
1436 (CD 3OD) δ 7.66-7.81 (m, 2 H), 7.37-7.60 (m, 1 H), 6.95-7.32 (m, 3 H), 6.60-6.81 (m, 1 H), 4.94-5.02 (m, 1 H), 3.82-3.96 (m, 0.6 H), 3.35-3.40 (m, 0.4 H), 2.82-3.20 (m, 2 H), 1.86-1.97 (m, 6 H) 446.1 [M+H] + 99.9%
1437 (CD 3OD) δ 7.56-7.69 (m, 2 H), 7.26-7.49 (m, 1 H), 6.83-7.20 (m, 3 H), 6.48-6.68 (m, 1 H), 4.82-4.90 (m, 1 H), 3.72-3.84 (m, 0.6 H), 3.23-3.27 (m, 0.4 H), 2.70-3.08 (m, 2 H), 1.75-1.83 (m, 6 H) 446.1 [M+H] + 99.4%
1438 (CD 3OD) δ 7.83 (dd, 1 H), 7.69-7.80 (m, 2 H), 7.38-7.61 (m, 1 H), 6.98-7.34 (m, 4 H), 6.61-6.80 (m, 1 H), 4.95-5.09 (m, 1 H), 4.05 (d, 3 H), 3.91 (ddd, 0.6 H), 3.36-3.41 (m, 0.4 H), 2.83-3.24 (m, 2 H) 466.1 [M+H] + 98.9%
1439 (CD 3OD) δ 7.71 (dd, 1 H), 7.56-7.68 (m, 2 H), 7.26-7.48 (m, 1 H), 6.84-7.22 (m, 4 H), 6.48-6.70 (m, 1 H), 4.83-4.96 (m, 1 H), 3.93 (d, 3 H), 3.79 (ddd, 0.6 H), 3.23-3.30 (m, 0.4 H), 2.71-3.13 (m, 2 H) 466.1 [M+H] + 100%
1440 (CD 3OD) δ 8.93 (d, 1 H), 8.36 (s, 1 H), 7.66-7.82 (m, 3 H), 7.45-7.58 (m, 1 H), 7.16-7.34 (m, 2.5 H), 6.98 (s, 0.5 H), 6.61-6.83 (m, 1 H), 4.96-5.14 (m, 1 H), 3.86-3.98 (m, 0.6 H), 3.36-3.43 (m, 0.4 H), 2.84-3.21 (m, 2 H) 502.1 [M+H] + 100%
1441 (CD 3OD) δ 8.93 (d, 1 H), 8.36 (s, 1 H), 7.66-7.83 (m, 3 H), 7.44-7.58 (m, 1 H), 7.16-7.34 (m, 2.5 H), 6.98 (s, 0.5 H), 6.63-6.80 (m, 1 H), 4.95-5.13 (m, 1 H), 3.86-3.99 (m, 0.6 H), 3.37-3.43 (m, 0.4 H), 2.84-3.22 (m, 2 H) 502.1 [M+H] + 99.6%
1442 (CD 3OD) δ 8.21 (dd, 1 H), 7.53-7.73 (m, 3 H), 7.29-7.45 (m, 1 H), 6.98-7.20 (m, 3.5 H), 6.85 (s, 0.5 H), 6.45-6.67 (m, 1 H), 4.83-4.98 (m, 1 H), 3.74-3.85 (m, 0.6 H), 3.22-3.28 (m, 0.4 H), 2.71-3.11 (m, 2 H) 502.2 [M+H] + 100%
1443 (CD 3OD) δ 8.23 (dd, 1 H), 7.54-7.73 (m, 3 H), 7.30-7.47 (m, 1 H), 7.02-7.20 (m, 3.5 H), 6.86 (s, 0.5 H), 6.49-6.69 (m, 1 H), 4.83-4.97 (m, 1 H), 3.73-3.86 (m, 0.6 H), 3.24-3.29 (m, 0.4 H), 2.72-3.12 (m, 2 H) 502.1 [M+H] + 99.9%
1444 (CD 3OD) δ 9.14 (d, 1 H), 8.47 (s, 1 H), 7.71 (br d, 1 H), 7.50-7.67 (m, 1.5 H), 7.13-7.27 (m, 1 H), 6.94-7.10 (m, 1.5 H), 6.59-6.86 (m, 1 H), 5.11 (br dd, 1 H), 3.83-4.02 (m, 0.5 H), 3.36-3.48 (m, 0.5 H), 2.80-3.25 (m, 2 H) 504.1 [M+H] + 100%
1445 (CD 3OD) δ 9.02 (d, 1 H), 8.36 (s, 1 H), 7.60 (br d, 1 H), 7.36-7.55 (m, 1.5 H), 7.01-7.13 (m, 1 H), 6.84-6.99 (m, 1.5 H), 6.48-6.79 (m, 1 H), 4.99 (br dd, 1 H), 3.74-3.86 (m, 0.5 H), 3.25-3.36 (m, 0.5 H), 2.66-3.15 (m, 2 H) 504.1 [M+H] + 99.6%
1446 (CD 3OD) δ 9.15 (d, 1 H), 8.48 (s, 1 H), 7.72 (d, 1 H), 7.40-7.54 (m, 1.5 H), 7.13 (ddd, 1 H), 7.00 (s, 0.5 H), 6.72 (dd, 1 H), 6.45-6.65 (m, 1 H), 5.07 (dd, 1 H), 3.87-4.01 (m, 0.5 H), 3.36-3.47 (m, 0.5 H), 2.82-3.25 (m, 2 H), 2.51-2.73 (m, 3 H) 484.1 [M+H] + 100%
1447 (CD 3OD) δ 9.15 (d, 1 H), 8.48 (s, 1 H), 7.71 (d, 1 H), 7.40-7.56 (m, 1.5 H), 7.07-7.21 (m, 1 H), 7.00 (s, 0.5 H), 6.66-6.78 (m, 1 H), 6.43-6.65 (m, 1 H), 5.07 (br dd, 1 H), 3.84-4.04 (m, 0.5 H), 3.39-3.47 (m, 0.5 H), 2.80-3.26 (m, 2 H), 2.50-2.74 (m, 3 H) 484.1 [M+H] + 99.7%
1448 (CD 3OD) δ 8.38-8.50 (m, 1 H), 7.70 (s, 1 H), 7.56-7.64 (m, 1 H), 7.41-7.52 (m, 0.3 H), 7.13-7.28 (m, 1 H), 6.92-6.99 (m,0.7 H), 6.79-6.91 (m, 1 H), 6.46-6.71 (m, 1 H), 4.93-5.04 (m, 1 H), 3.65-3.84 (m, 0.7 H), 3.34-3.43 (m, 1 H), 3.28-3.31 (m, 0.3 H), 2.92-3.22 (m, 1 H), 2.83 (br dd, 1 H), 1.45 (d, 6 H) 378.2 [M+H] + 100%
1449 (CD 3OD) δ 8.33-8.52 (m, 1 H), 7.71 (s, 1 H), 7.55-7.64 (m, 1 H), 7.45-7.49 (m, 0.3 H), 7.14-7.25 (m, 1 H), 6.92-6.97 (m, 0.7 H), 6.83-6.90 (m, 1 H), 6.53-6.65 (m, 1 H), 4.91 – 5.02 (m, 1 H), 3.75 (ddd, 0.7 H), 3.34-3.44 (m, 1 H), 3.29-3.31 (m, 0.3 H) , 2.90-3.24 (m, 1 H), 2.83 (br dd, 1 H), 1.45 (d, 6 H) 378.2 [M+H] + 100%
1450 (CD 3OD) δ 8.24-8.37 (m, 1 H), 7.68-7.75 (m, 1 H), 7.46 (s, 0.3 H), 6.97-7.03 (m, 1 H), 6.95 (s, 0.7H), 6.76-6.82 (m, 1 H), 6.53-6.66 (m, 1 H), 4.97 (br dd, 1 H), 3.70-3.80 (m, 1 H), 3.34-3.44 (m, 1 H), 2.93-3.21 (m, 1 H), 2.83 (br dd, 1 H), 2.38-2.49 (m, 3 H), 1.45 (d, 6 H) 392.2 [M+H] + 100%
1451 (CD 3OD) δ 8.23-8.37 (m, 1 H), 7.70 (s, 1 H), 7.40-7.50 (m, 0.3 H), 6.97-7.03 (m, 1 H), 6.95 (s, 0.7 H), 6.75-6.83 (m, 1 H), 6.52-6.67 (m, 1 H), 4.97 (br dd, 1 H), 3.68-3.82 (m, 0.7 H), 3.34-3.44 (m, 1 H), 3.29-3.32 (m, 0.3 H), 2.93-3.21 (m, 1 H), 2.77-2.88 (m, 1 H), 2.37-2.50 (m, 3 H), 1.45 (d, 6 H) 392.2 [M+H] + 99.3%
1452 (CD 3OD) δ 8.27-8.43 (m, 1 H), 7.71 (s, 1 H), 7.37 (br d, 0.3 H), 6.90-7.04 (m, 1.7 H), 6.80-6.89 (m, 1 H), 6.68-6.79 (m, 1 H), 5.00 (dd, 1 H), 3.69-3.80 (m, 0.7 H), 3.34-3.44 (m, 1 H), 3.30 (br d, 0.3 H), 2.94-3.22 (m, 1 H), 2.84 (br dd, 1 H), 1.45 (d, 6 H) 396.2 [M+H] + 100%
1453 (CD 3OD) δ 8.26-8.43 (m, 1 H), 7.71 (s, 1 H), 7.36-7.54 (m, 0.3 H), 6.59-7.09 (m, 3.7 H), 4.92-5.04 (m, 1 H), 3.68-3.81 (m, 0.7 H), 3.34-3.45 (m, 1 H), 3.25-3.30 (m, 0.3 H), 2.92-3.23 (m, 1 H), 2.84 (br dd, 1 H), 1.45 (d, 6 H) 396.1 [M+H] + 99.5%
1454 (CD 3OD) δ 8.45 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.85 (t, 1 H), 6.65 (s, 1 H), 6.27 (s, 1 H), 4.21 (dd, 1 H), 3.62-3.77 (m, 1 H), 2.95-3.08 (m, 1 H), 2.79 (br dd, 1 H), 2.04-2.13 (m, 1 H), 1.04-1.15 (m, 4 H) 382.1 [M+H] + 100%
1455 (CD 3OD) δ 8.45 (d, 1 H), 7.68 (s, 1 H), 7.31 (d, 1 H), 6.86 (t, 1 H), 6.65 (s, 1 H), 6.27 (br s, 1 H), 4.21 (dd, 1 H), 3.61-3.74 (m, 1 H), 2.97-3.11 (m, 1 H), 2.80 (br dd, 1 H), 1.98-2.16 (m, 1 H), 1.03-1.14 (m, 4 H) 382.1 [M+H] + 99.5%
1456 (DMSO- d 6) δ 12.02-12.24 (m, 1 H), 8.00 (d, 1 H), 7.47-7.71 (m, 2 H), 7.17-7.42 (m, 1.4 H), 6.94-7.02 (m, 1 H), 6.66-6.93 (m, 2.6 H), 4.77-4.96 (m, 1 H), 4.00 (s, 3 H), 3.60-3.86 (m, 0.8 H), 3.37 (br s, 0.2 H), 2.85-3.10 (m, 1 H), 2.69-2.84 (m, 1 H) 434.2 [M+H] + 92.8%
1457 (DMSO- d 6) δ 12.09 (br s, 1 H), 8.00 (d, 1 H), 7.48-7.70 (m, 2 H), 7.19-7.42 (m, 1.4 H), 6.94-7.01 (m, 1 H), 6.70-6.94 (m, 2.6 H), 4.72-4.96 (m, 1 H), 4.00 (s, 3 H), 3.64-3.84 (m, 0.7 H), 3.35-3.40 (m, 0.3 H), 2.84-3.11 (m, 1 H), 2.70-2.84 (m, 1 H) 434.2 [M+H] + 97.8%
1458 (DMSO- d 6) δ 11.87-12.43 (m, 1 H), 8.70 (br d, 1 H), 8.10 (br t, 1 H), 7.83 (dt, 1 H), 7.49-7.67 (m, 2 H), 7.29 (br d, 1 H), 7.15 (br s, 0.3 H), 6.69-6.96 (m, 2.7 H), 4.83 (br dd, 1 H), 3.76 (br s, 0.7 H), 3.36-3.46 (m, 0.3 H), 2.69-3.13 (m, 2 H) 449.2 [M+H] + 100%
1459 (DMSO- d 6) δ 11.96-12.28 (m, 1 H), 8.70 (br d, 1 H), 8.11 (br t, 1 H), 7.83 (dt, 1 H), 7.47-7.69 (m, 2 H), 7.21-7.39 (m, 1 H), 7.14 (s, 0.3 H), 6.69-6.99 (m, 2.7 H), 4.83 (br dd, 1 H), 3.62-3.86 (m, 0.7 H), 3.36-3.44 (m, 0.3 H), 2.71-3.13 (m, 2 H) 449.1 [M+H] + 100%
1460 (DMSO- d 6) δ 12.11 (br s, 1 H), 9.32-9.65 (m, 1 H), 8.83-9.01 (m, 2 H), 7.50-7.72 (m, 2 H), 7.21-7.39 (m, 1 H), 7.12 (s, 0.3 H), 6.68-7.00 (m, 2.7 H), 4.83 (br dd, 1 H), 3.64-3.87 (m, 0.7 H), 3.40 (br t, 0.3 H), 2.72-3.13 (m, 2 H) 432.1 [M+H] + 100%
1461 (DMSO- d 6) δ 12.05-12.26 (m, 1 H), 9.18-9.73 (m, 1 H), 8.94 (br d, 2 H), 7.49-7.70 (m, 2 H), 7.22-7.39 (m, 1 H), 7.12 (s, 0.3 H), 6.71-6.97 (m, 2.7 H), 4.83 (br d, 1 H), 3.78 (br t, 0.7 H), 3.40 (br s, 0.3 H), 2.71-3.15 (m, 2 H) 432.1 [M+H] + 100%
1462 (CD 3OD) δ 7.92-8.21 (m, 1 H), 7.71 (d, 1 H), 7.59 (s, 0.3 H), 7.37-7.53 (m, 1 H), 7.16-7.33 (m, 1 H), 6.98 (s, 0.7 H), 6.55-6.87 (m, 2 H), 5.13 (br dd, 1 H), 3.91 (s, 3 H), 3.41-3.85 (m, 1 H), 2.95-3.26 (m, 1 H), 2.79-2.93 (m, 1 H), 2.64-2.74 (m, 3 H) 448.1 [M+H] + 100%
1463 (CD 3OD) δ 7.91-8.13 (m, 1 H), 7.71 (d, 1 H), 7.59 (s, 0.4 H), 7.42-7.54 (m, 1 H), 7.15-7.37 (m, 1 H), 6.98 (s, 0.6 H), 6.50-6.89 (m, 2 H), 5.07-5.17 (m, 1 H), 3.91 (s, 3 H), 3.45-3.85 (m, 1 H), 2.98-3.23 (m, 1 H), 2.80-2.92 (m, 1 H), 2.66-2.74 (m, 3 H) 448.1 [M+H] + 96.8%
1464 (CD 3OD) δ 8.41-8.63 (m, 1 H), 8.05 (d, 1 H), 7.65-7.96 (m, 2 H), 7.34-7.60 (m, 2.3 H), 6.73-7.15 (m, 3.7 H), 5.03 (br dd, 1 H), 3.71-3.86 (m, 0.5 H), 3.35-3.46 (m, 0.5 H), 2.79-3.24 (m, 2 H), 2.62 (s, 3 H) 477.2 [M+H] + 100%
1465 (CD 3OD) δ 8.49-8.63 (m, 1 H), 8.09 (d, 1 H), 7.80-7.99 (m, 2 H), 7.38-7.60 (m, 2.3 H), 6.74-7.17 (m, 3.7 H), 4.95-5.11 (m, 1 H), 3.78 (ddd, 0.5 H), 3.41 (td, 0.5 H), 2.80-3.27 (m, 2 H), 2.64 (s, 3 H) 477.1 [M+H] + 98.5%
1466 (CD 3OD) δ 8.49-8.63 (m, 1 H), 8.18-8.35 (m, 1 H), 7.39-7.73 (m, 2.3 H), 6.75-7.13 (m, 3.7 H), 5.09 (dd, 1 H), 3.91 (s, 3 H), 3.70-3.81 (m, 0.5 H), 3.39 (td, 0.5 H), 2.79-3.24 (m, 2 H), 2.47-2.60 (m, 3 H) 480.2 [M+H] + 100%
1467 (CD 3OD) δ 8.49-8.63 (m, 1 H), 8.20-8.32 (m, 1 H), 7.35-7.75 (m, 2.3 H), 6.76-7.14 (m, 3.7 H), 5.09 (br dd, 1 H), 3.91 (s, 3 H), 3.70-3.81 (m, 0.5 H), 3.39 (td, 0.5 H), 2.80-3.24 (m, 2 H), 2.43-2.61 (m, 3 H) 480.2 [M+H] + 99.8%
1468 (CD 3OD) δ 9.32 (s, 1 H), 8.82 (dd, 1 H), 8.56 (ddt, 1 H), 7.65-7.81 (m, 3 H), 6.99-7.61 (m, 4 H), 6.62-6.84 (m, 1 H), 4.96-5.16 (m, 1 H), 3.88-4.00 (m, 0.6 H), 3.36-3.44 (m, 0.4 H), 2.84-3.26 (m, 2 H) 463.2 [M+H] + 100%
1469 (CD 3OD) δ 9.32 (s, 1 H), 8.76-8.86 (m, 1 H), 8.56 (ddt, 1 H), 7.65-7.80 (m, 3 H), 6.99-7.59 (m, 4 H), 6.62-6.83 (m, 1 H), 4.95-5.14 (m, 1 H), 3.89-3.99 (m, 0.6 H), 3.36-3.44 (m, 0.4 H), 2.85-3.27 (m, 2 H) 463.1 [M+H] + 99.6%
1470 (CD 3OD) δ 8.27-8.44 (m, 1 H), 8.10-8.18 (m, 1 H), 7.96 (t, 1 H), 7.75 (br s, 1 H), 7.54 (d, 1.3 H), 6.90-7.08 (m, 1.7 H), 6.74-6.89 (m, 2 H), 5.05 (br dd, 1 H), 3.75-3.87 (m, 0.5 H), 3.39-3.53 (m, 0.5 H), 2.82-3.29 (m, 2 H), 2.67 (s, 3 H) 445.2 [M+H] + 99.3%
1471 (CD 3OD) δ 8.17-8.29 (m, 1 H), 7.97-8.03 (m, 1 H), 7.84 (t, 1 H), 7.67 (br d, 1 H), 7.42 (d, 1.3 H), 6.81-6.92 (m, 1.7 H), 6.66-6.79 (m, 2 H), 4.94 (br dd, 1 H), 3.64-3.74 (m, 0.5 H), 3.26-3.39 (m, 0.5 H), 2.70-3.17 (m, 2 H), 2.54 (s, 3 H) 445.1 [M+H] + 88.9%
1472 (CD 3OD) δ 9.02 (s, 1 H), 8.35 (s, 1 H), 8.11-8.26 (m, 1 H), 7.34-7.84 (m, 1.3 H), 6.88 (br t, 1.7 H), 6.68 (br s, 1 H), 6.40-6.59 (m, 1 H), 4.94 (br dd, 1 H), 3.68 (br t, 0.7 H), 3.31 (br t, 0.3 H), 2.67-3.16 (m, 2 H), 2.26-2.41 (m, 3 H) 484.1 [M+H] + 100%
1473 (CD 3OD) δ 9.02 (s, 1 H), 8.35 (s, 1 H), 8.11-8.23 (m, 1 H), 7.43-7.64 (m, 1.3 H), 6.82-6.91 (m, 1.7 H), 6.61-6.71 (m, 1 H), 6.42-6.57 (m, 1 H), 4.94 (br dd, 1 H), 3.60-3.75 (m, 0.7 H), 3.25-3.35 (m, 0.3 H), 2.67-3.14 (m, 2 H), 2.26-2.39 (m, 3 H) 484.1 [M+H] + 99.6%
1474 (CD 3OD) δ 8.52 (d, 1 H), 7.71 (s, 1 H), 7.41-7.59 (m, 1.4 H), 7.18-7.32 (m, 2 H), 6.99 (s, 0.6 H), 6.72-6.87 (m, 1 H), 6.61-6.71 (m, 1 H), 5.08 (br dd, 1 H), 3.79-3.94 (m, 0.6 H), 3.40-3.51 (m, 0.4 H), 3.14-3.24 (m, 0.7 H), 3.03 (br t, 0.3 H), 2.87 (br d, 1 H) 488.1 [M+H] + 100%
1475 (CD 3OD) δ 8.52 (d, 1 H), 7.72 (br s, 1 H), 7.42-7.59 (m, 1.3 H), 7.19-7.34 (m, 2 H), 6.99 (s, 0.7 H), 6.72-6.88 (m, 1 H), 6.56-6.71 (m, 1 H), 5.08 (br dd, 0.6 H), 4.97 (br d, 0.4 H), 3.80-3.91 (m, 0.6 H), 3.40-3.54 (m, 0.4 H), 3.13-3.28 (m, 0.8 H), 2.98-3.09 (m, 0.2 H), 2.87 (br d, 1 H) 488.1 [M+H] + 100%
1476 (CD 3OD) δ 8.35-8.54 (m, 2 H), 7.49-7.75 (m, 1 H), 7.25-7.34 (m, 2 H), 6.70-7.00 (m, 3 H), 4.94-5.09 (m, 1 H), 3.73-3.84 (m, 0.6 H), 3.41 (br dd, 0.4 H), 3.15-3.26 (m, 0.7 H), 3.00 (br d, 0.3 H), 2.80-2.90 (m, 1 H) 504.1 [M+H] + 100%
1477 (CD 3OD) δ 8.37-8.53 (m, 2 H), 7.49-7.73 (m, 1 H), 7.25-7.32 (m, 2 H), 6.71-6.98 (m, 3 H), 4.92-5.09 (m, 1 H), 3.72-3.84 (m, 0.7 H), 3.41 (td, 0.3 H), 3.14-3.25 (m, 0.7 H), 2.95-3.07 (m, 0.3 H), 2.81-2.89 (m, 1 H) 504.1 [M+H] + 88.6%
1478 (CD 3OD) δ 8.49 (d, 1 H), 8.23-8.33 (m, 1 H), 7.50-7.75 (m, 1 H), 7.26 (d, 1 H), 6.94-7.01 (m, 2 H), 6.73-6.81 (m, 1 H), 6.58-6.67 (m, 1 H), 4.91-5.06 (m, 1 H), 3.74-3.84 (m, 0.7 H), 3.43 (td, 0.3 H), 3.14-3.25 (m, 0.7 H), 2.96-3.06 (m, 0.3 H), 2.78-2.89 (m, 1 H), 2.39-2.48 (m, 3 H) 484.2 [M+H] + 100%
1479 (CD 3OD) δ 8.50 (d, 1 H), 8.22-8.33 (m, 1 H), 7.53-7.90 (m, 1 H), 7.26 (d, 1 H), 6.94-7.03 (m, 2 H), 6.74-6.82 (m, 1 H), 6.59-6.68 (m, 1 H), 4.91-5.09 (m, 1 H), 3.72-3.84 (m, 0.7 H), 3.43 (td, 0.3 H), 3.16-3.26 (m, 0.7 H), 2.97-3.08 (m, 0.3 H), 2.87 (br dd, 1 H), 2.38-2.48 (m, 3 H) 484.1 [M+H] + 87.8%
1480 (CD 3OD) δ 8.48-8.63 (m, 2 H), 7.70 (s, 1.3 H), 7.44 (br d, 1 H), 7.08-7.30 (m, 1.2 H), 6.73-7.01 (m, 3.5 H), 4.93-5.09 (m, 1 H), 3.71-3.87 (m, 0.7 H), 3.36-3.44 (m, 0.3 H), 3.15-3.26 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.79-2.90 (m, 1 H) 520.2 [M+H] + 100%
1481 (CD 3OD) δ 8.47-8.64 (m, 2 H), 7.53-7.73 (m, 1.3 H), 7.44 (br d, 1 H), 7.09-7.29 (m, 1.2 H), 6.74-7.01 (m, 3.5 H), 4.93-5.10 (m, 1 H), 3.73-3.83 (m, 0.7 H), 3.40 (td, 0.3 H), 3.16-3.25 (m, 0.7 H), 3.01 (br s, 0.3 H), 2.81-2.90 (m, 1 H) 520.2 [M+H] + 89.6%
1482 (CD 3OD) δ 8.49 (d, 1 H), 8.26-8.38 (m, 1 H), 7.46-7.73 (m, 1.3 H), 7.27 (d, 1 H), 6.72-7.01 (m, 3.7 H), 4.92-5.08 (m, 1 H), 3.79 (ddd, 0.7 H), 3.43 (td, 0.3 H), 3.12-3.24 (m, 0.7 H), 2.95-3.06 (m, 0.3 H), 2.79-2.90 (m, 1 H) 488.2 [M+H] + 87.1%
1483 (CD 3OD) δ 8.49 (d, 1 H), 8.27-8.37 (m, 1 H), 7.49-7.71 (m, 1.3 H), 7.26 (d, 1 H), 6.73-7.00 (m, 3.7 H), 4.92-5.08 (m, 1 H), 3.79 (ddd, 0.7 H), 3.43 (td, 0.3 H), 3.12-3.24 (m, 0.7 H), 2.95-3.07 (m, 0.3 H), 2.78-2.90 (m, 1 H) 488.2 [M+H] + 90.0%
1484 (CD 3OD) δ 8.37-8.53 (m, 1 H), 7.71 (s, 1 H), 7.45 (s, 0.3 H), 7.28-7.35 (m, 1 H), 6.94 (s, 0.7 H), 6.81-6.90 (m, 1 H), 6.64-6.79 (m, 1 H), 5.00 (br dd, 1 H), 3.67-3.81 (m, 0.7 H), 3.34-3.45 (m, 1.3 H), 2.93-3.21 (m, 1 H), 2.84 (br dd, 1 H), 1.46 (d, 6 H) 412.1 [M+H] + 100%
1485 (CD 3OD) δ 8.39-8.50 (m, 1 H), 7.71 (s, 1 H), 7.45 (s, 0.3 H), 7.27-7.36 (m, 1 H), 6.94 (s, 0.7 H), 6.83-6.91 (m, 1 H), 6.64-6.79 (m, 1 H), 5.00 (br dd, 1 H), 3.64-3.85 (m, 0.7 H), 3.34-3.45 (m, 1.3 H), 2.92-3.22 (m, 1 H), 2.84 (br dd, 1 H), 1.46 (d, 6 H) 412.1 [M+H] + 96.2%
1486 (CD 3OD) δ 8.62-8.75 (m, 1 H), 7.60-7.76 (m, 2 H), 7.41 (s, 0.3 H), 6.89-7.07 (m, 1.7 H), 6.70-6.84 (m, 1 H), 4.95-5.07 (m, 1 H), 3.69-3.79 (m, 1 H), 3.35-3.45 (m, 1 H), 2.91-3.25 (m, 1 H), 2.84 (br d, 1 H), 1.38-1.51 (m, 6 H) 446.2 [M+H] + 100%
1487 (CD 3OD) δ 8.62-8.78 (m, 1 H), 7.60 (s, 2 H), 7.40-7.51 (m, 0.3 H), 6.90-7.06 (m, 1.7 H), 6.69-6.85 (m, 1 H), 4.93-5.06 (m, 1 H), 3.84 (br d, 1 H), 3.35-3.46 (m, 1 H), 2.91-3.24 (m, 1 H), 2.84 (br dd, 1 H), 1.36-1.51 (m, 6 H) 446.2 [M+H] + 99.8%
1488 (CD 3OD) δ 7.70 (d, 1 H), 7.54-7.66 (m, 1 H), 7.38-7.51 (m, 0.4 H), 7.14-7.24 (m, 1 H), 7.01-7.09 (m, 1 H), 6.96 (br s, 0.6 H), 6.79 (s, 0.6 H), 6.65 (s, 0.4 H), 4.92-5.05 (m, 1 H), 3.80-3.97 (m, 0.6 H), 3.34-3.44 (m, 1.4 H), 2.91-3.23 (m, 1 H), 2.74-2.90 (m, 1 H), 1.45 (d, 6 H) 412.1 [M+H] + 100%
1489 (CD 3OD) δ 7.80 (d, 1 H), 7.56-7.68 (m, 1 H), 7.49 (s, 0.4 H), 7.14-7.24 (m, 1 H), 7.02-7.09 (m, 1 H), 6.98 (s, 0.6 H), 6.80 (s, 0.6 H), 6.67 (s, 0.4 H), 4.93-5.06 (m, 1 H), 3.78-3.94 (m, 0.7 H), 3.34-3.44 (m, 1.3 H), 2.91-3.24 (m, 1 H), 2.86 (dd, 1 H), 1.45 (d, 6 H) 412.1 [M+H] + 99.7%
1490 (CD 3OD) δ 7.69 (d, 1 H), 7.37-7.52 (m, 1.4 H), 7.08-7.18 (m, 1 H), 6.97 (br s, 0.6 H), 6.68-6.77 (m, 1 H), 6.41-6.63 (m, 1 H), 4.92-5.01 (m, 1 H), 3.82-3.95 (m, 0.7 H), 3.34-3.42 (m, 1.3 H), 2.92-3.21 (m, 1 H), 2.84 (br d, 1 H), 2.55-2.73 (m, 3 H), 1.45 (d, 6 H) 392.2 [M+H] + 100%
1491 (CD 3OD) δ 7.70 (d, 1 H), 7.37-7.54 (m, 1.4 H), 7.07-7.19 (m, 1 H), 6.97 (s, 0.6 H), 6.68-6.78 (m, 1 H), 6.41-6.65 (m, 1 H), 4.92-5.01 (m, 1 H), 3.81-3.96 (m, 0.7 H), 3.34-3.43 (m, 1.3 H), 2.91-3.20 (m, 1 H), 2.78-2.90 (m, 1 H), 2.56-2.72 (m, 3 H), 1.45 (d, 6 H)    392.2 [M+H] + 99.2%
1492 (CD 3OD) δ 7.65-7.80 (m, 2 H), 7.58 (s, 0.2 H), 7.40-7.50 (m, 1 H), 7.25-7.32 (m, 1.3 H), 7.14-7.24 (m, 1 H), 6.95 (s, 0.5 H), 6.58-6.81 (m, 1 H), 4.92-5.03 (m, 1 H), 3.79-3.95 (m, 0.6 H), 3.34-3.40 (m, 1.4 H), 2.92-3.21 (m, 1 H), 2.84 (br d, 1 H), 1.45 (d, 6 H) 428.2 [M+H] + 100%
1493 (CD 3OD) δ 7.64-7.81 (m, 2 H), 7.58 (s, 0.2 H), 7.39-7.48 (m, 1.3 H), 7.24-7.35 (m, 1 H), 7.12-7.23 (m, 1 H), 6.95 (s, 0.5 H), 6.54-6.80 (m, 1 H), 4.92-5.05 (m, 1 H), 3.77-3.96 (m, 0.6 H), 3.34-3.41 (m, 1.4 H), 2.91-3.22 (m, 1 H), 2.75-2.89 (m, 1 H), 1.45 (d, 6 H) 428.2 [M+H] + 94.2%
1494 (DMSO- d 6) δ 11.64-12.72 (m, 1 H), 8.50-9.07 (m, 1 H), 8.17-8.49 (m, 1 H), 7.61-7.74 (m, 1 H), 7.45-7.61 (m, 2 H), 7.21-7.36 (m, 1 H), 6.52-7.19 (m, 3 H), 4.74-4.96 (m, 1 H), 3.69-3.83 (m, 1 H), 2.97-3.10 (m, 2 H), 2.82-2.90 (m, 3 H), 2.75-2.80 (m, 1 H) 445.1 [M+H] + 100%
1495 (DMSO- d 6) δ 11.80-12.36 (m, 1 H), 8.70 (br s, 1 H), 8.14-8.47 (m, 1 H), 7.41-7.73 (m, 3 H), 7.19-7.37 (m, 1 H), 7.10 (s, 1 H), 6.64-6.95 (m, 3 H), 4.67-4.95 (m, 1 H), 3.58-3.94 (m, 1 H), 2.98-3.14 (m, 1 H), 2.82-2.90 (m, 3 H), 2.69-2.80 (m, 1 H) 445.1 [M+H] + 98.2%
1496 (CD 3OD) δ 8.03-8.27 (m, 1 H), 7.95 (t, 1 H), 7.71 (s, 1 H), 7.32-7.63 (m, 2.3 H), 7.20-7.31 (m, 1 H), 7.00 (s, 0.7 H), 6.71-6.87 (m, 1 H), 6.56-6.71 (m, 1 H), 5.01-5.13 (m, 1 H), 3.79-3.93 (m, 0.7 H), 3.48 (br dd, 0.3 H), 2.98-3.25 (m, 1 H), 2.88 (br dd, 1 H), 2.66 (s, 3 H) 445.1 [M+H] + 100%
1497 (CD 3OD) δ 8.06-8.31 (m, 1 H), 7.96 (t, 1 H), 7.71 (s, 1 H), 7.35-7.64 (m, 2.4 H), 7.18-7.34 (m, 1 H), 7.00 (s, 0.6 H), 6.50-6.91 (m, 2 H), 4.97-5.09 (m, 1 H), 3.43-3.91 (m, 1 H), 2.97-3.25 (m, 1 H), 2.88 (br dd, 1 H), 2.66 (s, 3 H) 445.2 [M+H] + 91.5%
1498 (CD 3OD) δ 9.04 (dd, 2 H), 7.68-7.77 (m, 3 H), 6.97-7.45 (m, 4 H), 6.60-6.80 (m, 1 H), 4.96-5.04 (m, 1 H), 3.88-3.99 (m, 0.6 H), 3.34-3.39 (m, 0.4 H), 2.84-3.23 (m, 2 H) 464.2 [M+H] + 100%
1499 (CD 3OD) δ 9.05 (dd, 2 H), 7.68-7.80 (m, 3 H), 6.98-7.47 (m, 4 H), 6.59-6.82 (m, 1 H), 4.96-5.04 (m, 1 H), 3.87-4.00 (m, 0.6 H), 3.35-3.40 (m, 0.4 H), 2.84-3.27 (m, 2 H) 464.2 [M+H] + 99.7%
1500 (CD 3OD) δ 8.64-8.69 (m, 1 H), 8.47 (d, 1 H), 7.68-7.81 (m, 2 H), 7.35-7.61 (m, 2 H), 6.96-7.32 (m, 3 H), 6.64-6.83 (m, 1 H), 4.96-5.16 (m, 1 H), 3.89-4.01 (m, 0.5 H), 3.36-3.45 (m, 0.5 H), 2.86-3.27 (m, 5 H) 477.1 [M+H] + 100%
1501 (CD 3OD) δ 8.63-8.68 (m, 1 H), 8.47 (br d, 1 H), 7.68-7.81 (m, 2 H), 7.35-7.61 (m, 2 H), 6.97-7.33 (m, 3 H), 6.62-6.85 (m, 1 H), 4.98-5.17 (m, 1 H), 3.88-4.00 (m, 0.5 H), 3.37-3.46 (m, 0.5 H), 2.85-3.26 (m, 5 H) 477.2 [M+H] + 99.4%
1502 (CD 3OD) δ 9.03 (s, 1 H), 8.36 (s, 1 H), 7.58-7.79 (m, 2 H), 7.24-7.51 (m, 1 H), 6.83-7.24 (m, 3 H), 6.49-6.73 (m, 1 H), 4.84-5.05 (m, 1 H), 3.72-3.87 (m, 0.5 H), 3.25-3.32 (m, 0.5 H), 2.84-3.14 (m, 1 H), 2.72-2.84 (m, 1 H) 520.1 [M+H] + 100%
1503 (CD 3OD) δ 9.03 (s, 1 H), 8.36 (s, 1 H), 7.55-7.74 (m, 2 H), 7.31-7.50 (m, 1 H), 6.83-7.28 (m, 3 H), 6.49-6.71 (m, 1 H), 4.85-4.98 (m, 1 H), 3.75-3.85 (m, 0.5 H), 3.24-3.31 (m, 0.5 H), 2.85-3.13 (m, 1 H), 2.69-2.85 (m, 1 H) 520.1 [M+H] + 97.1%
1504 (CD 3OD) δ 8.98-9.09 (m, 1 H), 8.25-8.42 (m, 2 H), 7.60 (s, 1 H), 7.45 (s, 0.3 H), 7.14-7.26 (m, 1 H), 6.85 (s, 0.7 H), 6.70-6.81 (m, 1 H), 6.59-6.69 (m, 1 H), 4.83-5.03 (m, 1 H), 3.67 (ddd, 0.7 H), 3.30 (td, 0.3 H), 2.83-3.14 (m, 1 H), 2.66-2.81 (m, 1 H) 504.1 [M+H] + 100%
1505 (CD 3OD) δ 9.09-9.19 (m, 1 H), 8.37-8.51 (m, 2 H), 7.72 (s, 1 H), 7.57 (br s, 0.3 H), 7.26-7.37 (m, 1 H), 6.97 (br s, 0.7 H), 6.81-6.91 (m, 1 H), 6.71-6.80 (m, 1 H), 4.94-5.13 (m, 1 H), 3.73-3.85 (m, 0.7 H), 3.42 (td, 0.3 H), 2.94-3.28 (m, 1 H), 2.77-2.94 (m, 1 H) 504.1 [M+H] + 99.5%
1506 (CD 3OD) δ 8.52 (d, 1 H), 8.38-8.50 (m, 1 H), 7.71 (s, 1 H), 7.48-7.67 (m, 1.3 H), 7.14-7.33 (m, 2 H), 6.93-7.05 (m, 0.7 H), 6.78-6.92 (m, 1 H), 6.57-6.70 (m, 1 H), 4.94-5.09 (m, 1 H), 3.66-3.91 (m, 0.7 H), 3.42-3.54 (m, 0.3 H), 2.94-3.27 (m, 1 H), 2.74-2.91 (m, 1 H) 470.1 [M+H] + 100%
1507 (CD 3OD) δ 8.52 (d, 1 H), 8.39-8.49 (m, 1 H), 7.71 (s, 1 H), 7.53-7.65 (m, 1.3 H), 7.29 (d, 1 H), 7.16-7.25 (m, 1 H), 6.99 (s, 0.7 H), 6.82-6.91 (m, 1 H), 6.59-6.68 (m, 1 H), 4.94-5.08 (m, 1 H), 3.74-3.86 (m, 0.7 H), 3.39-3.47 (m, 0.3 H), 2.97-3.26 (m, 1 H), 2.78-2.91 (m, 1 H) 470.2 [M+H] + 98.9%
1508 (CD 3OD) δ 8.40-8.59 (m, 1 H), 7.72 (d, 1 H), 7.54-7.66 (m, 1 H), 7.44-7.53 (m, 0.4 H), 7.29 (t, 1 H), 7.12-7.24 (m, 1 H), 6.95-7.09 (m, 1.6 H), 6.54-6.87 (m, 1 H), 4.93-5.13 (m, 1 H), 3.80-4.06 (m, 0.5 H), 3.34-3.48 (m, 0.5 H), 2.96-3.28 (m, 1 H), 2.88 (br d, 1 H) 504.1 [M+H] + 100%
1509 (CD 3OD) δ 8.52 (t, 1 H), 7.72 (d, 1 H), 7.55-7.67 (m, 1 H), 7.49 (s, 0.4 H), 7.29 (br s, 1 H), 7.12-7.23 (m, 1 H), 6.95-7.09 (m, 1.6 H), 6.60-6.85 (m, 1 H), 4.93-5.13 (m, 1 H), 3.84-4.00 (m, 0.5 H), 3.35-3.45 (m, 0.5 H), 2.95-3.27 (m, 1 H), 2.82-2.93 (m, 1 H) 504.1 [M+H] + 99.5%
1510 (CD 3OD) δ 8.43-8.61 (m, 1 H), 7.65-7.79 (m, 1 H), 7.36-7.56 (m, 1.5 H), 7.29 (t, 1 H), 7.07-7.20 (m, 1 H), 7.01 (s, 0.5 H), 6.66-6.78 (m, 1 H), 6.40-6.66 (m, 1 H), 4.95-5.12 (m, 1 H), 4.03 (br d, 0.5 H), 3.36-3.45 (m, 0.5 H), 3.09 (s, 1 H), 2.79-2.93 (m, 1 H), 2.42-2.74 (m, 3 H) 484.2 [M+H] + 100%
1511 (CD 3OD) δ 8.39-8.61 (m, 1 H), 7.71 (d, 1 H), 7.38 (s, 1.5 H), 7.29 (t, 1 H), 6.93-7.19 (m, 1.5 H), 6.66-6.78 (m, 1 H), 6.37-6.65 (m, 1 H), 4.97-5.11 (m, 1 H), 3.78-4.16 (m, 0.5 H), 3.37-3.43 (m, 0.5 H), 2.95-3.27 (m, 1 H), 2.80-2.93 (m, 1 H), 2.45-2.73 (m, 3 H) 484.2 [M+H] + 97.6%
1512 (CD 3OD) δ 8.62-8.72 (m, 1 H), 8.50 (d, 1 H), 7.51-7.74 (m, 2 H), 7.27 (d, 1 H), 6.93-7.03 (m, 2 H), 6.76-6.83 (m, 1 H), 4.93-5.09 (m, 1 H), 3.74-3.83 (m, 0.7 H), 3.37-3.46 (m, 0.3 H), 3.20 (br t, 0.7 H), 2.96-3.06 (m, 0.3 H), 2.85 (br d, 1 H) 538.2 [M+H] + 99.0%
1513 (CD 3OD) δ 8.63-8.72 (m, 1 H), 8.50 (d, 1 H), 7.52-7.73 (m, 2 H), 7.27 (d, 1 H), 6.93-7.04 (m, 2 H), 6.75-6.84 (m, 1 H), 4.93-5.11 (m, 1 H), 3.73-3.84 (m, 0.7 H), 3.41 (td, 0.3 H), 3.14-3.27 (m, 0.7 H), 2.95-3.06 (m, 0.3 H), 2.80-2.90 (m, 1 H) 538.2 [M+H] + 91.3%
1514 (CD 3OD) δ 8.37-8.54 (m, 1 H), 7.45-7.86 (m, 2 H), 7.13-7.31 (m, 1 H), 6.48-7.00 (m, 3 H), 4.99 (br dd, 1 H), 3.68-4.01 (m, 1.6 H), 3.39 (td, 0.4 H), 2.72-3.27 (m, 2 H), 2.42-2.61 (m, 4 H), 1.96-2.34 (m, 2 H) 390.2 [M+H] + 99.3%
1515 (CD 3OD) δ 8.34-8.53 (m, 1 H), 7.40-7.73 (m, 2 H), 7.09-7.26 (m, 1 H), 6.48-7.02 (m, 3 H), 4.96 (br dd, 1 H), 3.67-3.99 (m, 1.6 H), 3.34-3.46 (m, 0.4 H), 2.73-3.22 (m, 2 H), 2.37-2.64 (m, 4 H), 1.90-2.29 (m, 2 H) 390.2 [M+H] + 96.0%
1516 (CD 3OD) δ 8.32-8.53 (m, 1 H), 7.69 (s, 1 H), 7.19-7.50 (m, 1 H), 6.60-7.01 (m, 3 H), 4.99 (dd, 1 H), 3.69-3.98 (m, 1.6 H), 3.34-3.44 (m, 0.4 H), 2.72-3.20 (m, 2 H), 2.39-2.62 (m, 4 H), 1.87-2.31 (m, 2 H) 424.1 [M+H] + 100%
1517 (CD 3OD) δ 8.30-8.60 (m, 1 H), 7.69 (s, 1 H), 7.23-7.51 (m, 1 H), 6.62-6.97 (m, 3 H), 4.99 (br dd, 1 H), 3.65-3.98 (m, 1.6 H), 3.36 (br dd, 0.4 H), 2.77-3.21 (m, 2 H), 2.39-2.63 (m, 4 H), 1.93-2.33 (m, 2 H) 424.1 [M+H] + 100%
1518 (CD 3OD) δ 8.57-8.79 (m, 1 H), 7.39-7.78 (m, 2 H), 6.65-7.11 (m, 3 H), 4.92-5.10 (m, 1 H), 3.60-3.95 (m, 2 H), 2.75-3.25 (m, 2 H), 2.43-2.61 (m, 4 H), 1.93-2.33 (m, 2 H) 458.2 [M+H] + 100%
1519 (CD 3OD) δ 8.55-8.78 (m, 1 H), 7.42-7.74 (m, 2 H), 6.56-7.17 (m, 3 H), 4.92-5.09 (m, 1 H), 3.65-3.94 (m, 1.6 H), 3.38 (td, 0.4 H), 2.74-3.25 (m, 2 H), 2.37-2.62 (m, 4 H), 1.92-2.32 (m, 2 H) 458.1 [M+H] + 100%
1520 (CD 3OD) δ 8.49-8.67 (m, 1 H), 7.69 (s, 1 H), 7.38-7.53 (m, 1 H), 6.66-7.16 (m, 4 H), 4.99 (br dd, 1 H), 3.64-3.99 (m, 1.6 H), 3.34-3.43 (m, 0.4 H), 2.75-3.22 (m, 2 H), 2.32-2.61 (m, 4 H), 1.94-2.29 (m, 2 H) 440.2 [M+H] + 100%
1521 (CD 3OD) δ 8.48-8.67 (m, 1 H), 7.69 (s, 1 H), 7.35-7.55 (m, 1 H), 6.64-7.15 (m, 4 H), 4.99 (br dd, 1 H), 3.65-4.01 (m, 1.6 H), 3.37 (br dd, 0.4 H), 2.71-3.25 (m, 2 H), 2.38-2.61 (m, 4 H), 1.92-2.28 (m, 2 H) 440.2 [M+H] + 97.0%
1522 (DMSO- d 6) δ 12.13 (br s, 1 H), 9.04-9.71 (m, 1 H), 8.73-9.01 (m, 1 H), 8.33-8.59 (m, 1 H), 7.44-7.80 (m, 3 H), 7.22-7.41 (m, 1 H), 7.06-7.19 (m, 0.3 H), 6.54-6.99 (m, 2.7 H), 4.82 (br dd, 1 H), 3.40-3.88 (m, 1 H), 2.73-3.16 (m, 2 H) 431.1 [M+H] + 100%
1523 (DMSO- d 6) δ 12.10 (br s, 1 H), 9.05-9.83 (m, 1 H), 8.86 (br d, 1 H), 8.22-8.68 (m, 1 H), 7.46-7.81 (m, 3 H), 7.19-7.43 (m, 1 H), 7.10 (s, 0.3 H), 6.60-7.00 (m, 2.7 H), 4.82 (br dd, 1 H), 3.41-3.82 (m, 1 H), 2.77-3.11 (m, 2 H) 431.1 [M+H] + 97.4%
1524 (DMSO- d 6) δ 12.11 (br s, 1 H), 8.52 (d, 1 H), 8.11-8.34 (m, 1 H), 7.48-7.76 (m, 3 H), 7.25-7.38 (m, 1 H), 7.21 (br d, 0.3 H), 6.31-7.10 (m, 2.7 H), 4.87 (br dd, 1 H), 3.96 (s, 3 H), 3.38-3.82 (m, 1 H), 2.72-3.12 (m, 2 H) 461.1 [M+H] + 99.4%
1525 (DMSO- d 6) δ 12.11 (br s, 1 H), 8.52 (d, 1 H), 8.15-8.30 (m, 1 H), 7.49-7.75 (m, 3 H), 7.25-7.35 (m, 1 H), 7.23 (br s, 0.4 H), 6.45-7.02 (m, 2.6 H), 4.68-4.99 (m, 1 H), 3.95 (s, 3 H), 3.38-3.81 (m, 1 H), 2.71-3.13 (m, 2 H) 461.1 [M+H] + 98.2%
1526 (CD 3OD) δ 7.62-7.72 (m, 2 H), 7.40-7.55 (m, 1 H), 7.20-7.29 (m, 1 H), 6.94-7.10 (m, 2 H), 6.60-6.81 (m, 2 H), 4.95-5.12 (m, 1 H), 4.27-4.37 (m, 3 H), 3.77-3.90 (m, 0.7 H), 3.40-3.50 (m, 0.3 H), 2.95-3.22 (m, 1 H), 2.80-2.91 (m, 1 H) 434.2 [M+H] + 100%
1527 (CD 3OD) δ 7.60-7.76 (m, 2 H), 7.39-7.57 (m, 1 H), 7.19-7.29 (m, 1 H), 6.92-7.11 (m, 2 H), 6.59-6.81 (m, 2 H), 5.09 (br dd, 1 H), 4.27-4.36 (m, 3 H), 3.83 (br s, 0.5 H), 3.37-3.51 (m, 0.5 H), 2.94-3.22 (m, 1 H), 2.77-2.92 (m, 1 H) 434.2 [M+H] + 99.4%
1528 (CD 3OD) δ 7.67-7.73 (m, 1 H), 7.41-7.52 (m, 2 H), 7.18-7.28 (m, 1 H), 6.96 (s, 1 H), 6.59-6.81 (m, 2 H), 5.10 (br dd, 0.5 H), 4.94 (br d, 0.5 H), 4.20-4.26 (m, 3 H), 3.84 (ddd, 0.5 H), 3.41 (td, 0.5 H), 3.15-3.25 (m, 1 H), 2.80-3.06 (m, 1 H), 2.32-2.41 (m, 3 H) 448.1 [M+H] + 98.6%
1529 (CD 3OD) δ 7.70 (br d, 1 H), 7.42-7.52 (m, 2 H), 7.24 (ddd, 1 H), 6.96 (s, 1 H), 6.60-6.80 (m, 2 H), 5.10 (dd, 0.7 H), 4.92-4.97 (m, 0.3 H), 4.21-4.24 (m, 3 H), 3.81-3.89 (m, 0.6 H), 3.41 (td, 0.4 H), 3.16-3.25 (m, 1 H), 2.82-3.05 (m, 1 H), 2.32-2.40 (m, 3 H) 448.2 [M+H] + 98.3%
1530 (CD 3OD) δ 8.52-8.63 (m, 1 H), 7.72 (s, 1 H), 7.39-7.58 (m, 1.3 H), 6.75-7.18 (m, 4.7 H), 4.92-5.09 (m, 1 H), 3.92 (s, 3 H), 3.78 (ddd, 0.5 H), 3.36-3.46 (m, 0.5 H), 2.79-3.27 (m, 2 H), 2.40 (s, 3 H) 480.1 [M+H] + 100%
1531 (CD 3OD) δ 8.50-8.64 (m, 1 H), 7.72 (s, 1 H), 7.35-7.59 (m, 1.3 H), 6.74-7.17 (m, 4.7 H), 4.92-5.13 (m, 1 H), 3.92 (s, 3 H), 3.72-3.85 (m, 0.5 H), 3.36-3.45 (m, 0.5 H), 2.80-3.27 (m, 2 H), 2.41 (s, 3 H) 480.1 [M+H] + 99.6%
1532 (CD 3OD) δ 8.52-8.68 (m, 1 H), 7.40-7.79 (m, 3.3 H), 6.76-7.17 (m, 4.7 H), 5.09 (br dd, 1 H), 4.23-4.39 (m, 3 H), 3.74-3.86 (m, 0.5 H), 3.38-3.50 (m, 0.5 H), 2.79-3.26 (m, 2 H) 466.1 [M+H] + 92.4%
1533 (CD 3OD) δ 8.37-8.56 (m, 1 H), 7.28-7.65 (m, 3.3 H), 6.64-7.05 (m, 4.7 H), 4.82-5.04 (m, 1 H), 4.15-4.27 (m, 3 H), 3.58-3.77 (m, 0.5 H), 3.25-3.38 (m, 0.5 H), 2.69-3.16 (m, 2 H) 466.1 [M+H] + 98.1%
1534 (CD 3OD) δ 9.48 (dd, 1 H), 8.82-8.90 (m, 2 H), 7.68-7.81 (m, 2 H), 7.39-7.61 (m, 1 H), 6.99-7.33 (m, 3 H), 6.62-6.84 (m, 1 H), 4.96-5.07 (m, 1 H), 3.89-3.99 (m, 0.6 H), 3.36-3.41 (m, 0.4 H), 2.86-3.26 (m, 2 H) 464.1 [M+H] + 100%
1535 (CD 3OD) δ 9.48 (dd, 1 H), 8.81-8.90 (m, 2 H), 7.69-7.82 (m, 2 H), 7.38-7.61 (m, 1 H), 6.99-7.34 (m, 3 H), 6.61-6.83 (m, 1 H), 4.96-5.08 (m, 1 H), 3.89-4.00 (m, 0.6 H), 3.36-3.42 (m, 0.4 H), 2.85-3.26 (m, 2 H) 464.1 [M+H] + 99.1%
1536 (CD 3OD) δ 7.68-7.79 (m, 2 H), 7.39-7.60 (m, 1 H), 6.97-7.31 (m, 3 H), 6.60-6.79 (m, 2 H), 4.95-5.08 (m, 1 H), 3.91 (d, 3.6 H), 3.35-3.41 (m, 0.4 H), 2.84-3.20 (m, 2 H), 2.40 (d, 3 H) 480.1 [M+H] + 100%
1537 (CD 3OD) δ 7.68-7.79 (m, 2 H), 7.38-7.60 (m, 1 H), 6.96-7.32 (m, 3 H), 6.60-6.79 (m, 2 H), 4.94-5.11 (m, 1 H), 3.91 (d, 3.6 H), 3.34-3.40 (m, 0.4 H), 2.82-3.23 (m, 2 H), 2.40 (d, 3 H) 480.2 [M+H] + 99.0%
1538 (CD 3OD) δ 8.99-9.06 (m, 1 H), 8.53-8.64 (m, 1 H), 8.37 (s, 1 H), 7.63 (br s, 1 H), 7.43-7.57 (m, 1.3 H), 6.82-6.95 (m, 1.7 H), 6.64-6.75 (m, 1 H), 4.83-5.04 (m, 1 H), 3.63-3.73 (m, 0.7 H), 3.31 (td, 0.3 H), 2.84-3.15 (m, 1 H), 2.76 (br d, 1 H) 538.2 [M+H] + 100%
1539 (CD 3OD) δ 8.98-9.07 (m, 1 H), 8.54-8.63 (m, 1 H), 8.33-8.40 (m, 1 H), 7.60 (br s, 1 H), 7.43-7.56 (m, 1.3 H), 6.82-6.94 (m, 1.7 H), 6.66-6.75 (m, 1 H), 4.82-5.04 (m, 1 H), 3.61-3.74 (m, 0.7 H), 3.31 (td, 0.3 H), 2.83-3.15 (m, 1 H), 2.77 (br s, 1 H) 538.2 [M+H] + 98.8%
1540 (CD 3OD) δ 9.15 (s, 1 H), 8.48 (s, 1 H), 8.28-8.39 (m, 1 H), 7.55-7.74 (m, 1.3 H), 6.93-7.03 (m, 1.7 H), 6.80-6.89 (m, 1 H), 6.72-6.79 (m, 1 H), 4.94-5.13 (m, 1 H), 3.80 (ddd, 0.7 H), 3.43 (td, 0.3 H), 2.95-3.25 (m, 1 H), 2.82-2.91 (m, 1 H) 488.2 [M+H] + 99.9%
1541 (CD 3OD) δ 9.03 (s, 1 H), 8.36 (s, 1 H), 8.16-8.27 (m, 1 H), 7.40-7.66 (m, 1.3 H), 6.81-6.92 (m, 1.7 H), 6.68-6.79 (m, 1 H), 6.60-6.68 (m, 1 H), 4.82-5.01 (m, 1 H), 3.63-3.73 (m, 0.7 H), 3.31 (td, 0.3 H), 2.84-3.14 (m, 1 H), 2.74 (br d, 1 H) 488.1 [M+H] + 99.3%
1542 (CD 3OD) δ 8.52 (dd, 1 H), 7.79-7.93 (m, 1 H), 7.65-7.77 (m, 1 H), 7.50-7.60 (m, 0.5 H), 7.20-7.41 (m, 3 H), 6.99 (s, 0.5 H), 6.63-6.91 (m, 1 H), 4.93-5.12 (m, 1 H), 3.88-4.07 (m, 0.5 H), 3.34-3.41 (m, 0.5 H), 2.96-3.26 (m, 1 H), 2.81-2.93 (m, 1 H) 538.1 [M+H] + 100%
1543 (CD 3OD) δ 8.46 (s, 1 H), 7.80-7.93 (m, 1 H), 7.65-7.78 (m, 1 H), 7.56 (s, 0.5 H), 7.21-7.41 (m, 3 H), 7.03 (s, 0.5 H), 6.63-6.92 (m, 1 H), 4.93-5.12 (m, 1 H), 4.05 (br d, 0.5 H), 3.37 (br d, 0.5 H), 2.96-3.25 (m, 1 H), 2.82-2.94 (m, 1 H) 538.1 [M+H] + 99.9%
1544 (CD 3OD) δ 8.44-8.56 (m, 1 H), 7.68-7.81 (m, 2 H), 7.59 (s, 0.1 H), 7.14-7.50 (m, 4.3 H), 7.11 (s, 0.1 H), 6.93-7.01 (m, 0.5 H), 6.56-6.83 (m, 1 H), 4.93-5.10 (m, 1 H), 3.83-4.01 (m, 0.5 H), 3.35-3.41 (m, 0.5 H), 2.95-3.27 (m, 1 H), 2.80-2.93 (m, 1 H) 520.1 [M+H] + 100%
1545 (CD 3OD) δ 8.52 (t, 1 H), 7.64-7.82 (m, 2 H), 7.59 (s, 0.2 H), 7.36-7.47 (m, 0.8 H), 7.07-7.34 (m, 3.5 H), 6.99 (s, 0.5 H), 6.59-6.82 (m, 1 H), 4.94-5.10 (m, 1 H), 3.83-3.98 (m, 0.6 H), 3.37 (br s, 0.4 H), 2.95-3.26 (m, 1 H), 2.80-2.93 (m, 1 H) 520.2 [M+H] + 99.7%
1546 (CD 3OD) δ 8.27-8.97 (m, 3 H), 7.94 (d, 1 H), 7.60-7.71 (m, 2 H), 7.46 (br d, 1 H), 6.39-7.18 (m, 3 H), 4.61 (br s, 1 H), 3.55 (s, 3 H), 3.01-3.16 (m, 1 H), 2.78 (br d, 1 H), 2.30 (s, 6 H) 509.2 [M+H] + 100%
1547 (CD 3OD) δ 8.14-9.03 (m, 3 H), 7.94 (d, 1 H), 7.60-7.70 (m, 2 H), 7.46 (d, 1 H), 6.28-7.19 (m, 3 H), 4.61 (br s, 1 H), 3.55 (s, 3 H), 3.02-3.14 (m, 1 H), 2.78 (br d, 1 H), 2.30 (s, 6 H) 509.2 [M+H] + 99.0%
1548 (CD 3OD) δ 8.12-9.00 (m, 3 H), 7.97 (d, 1 H), 7.56-7.83 (m, 2 H), 7.45 (d, 1 H), 6.45-7.19 (m, 3 H), 4.59-4.79 (m, 1 H), 4.54 (s, 2 H), 3.52-4.12 (s, 1 H)3.32-3.48 (m, 3 H)2.98-3.22 (m, 1 H), 2.68-2.89 (m, 1 H) 496.2 [M+H] + 100%
1549 (CD 3OD) δ 8.69-8.94 (m, 3 H), 7.97 (d, 1 H), 7.58-7.78 (m, 2 H), 7.45 (d, 1 H), 6.39-7.14 (m, 3 H), 4.59-4.80 (m, 1 H), 4.55 (s, 2 H), 3.40-4.05 (m, 4 H), 3.01-3.20 (m, 1 H), 2.70-2.90 (m, 1 H) 496.2 [M+H] + 99.4%
1550 (DMSO- d 6) δ 12.06 (br s, 1 H), 9.50 (s, 1 H), 9.04 (br s, 1 H), 8.41-8.78 (m, 2 H), 8.14-8.26 (m, 2 H), 7.88-8.07 (m, 2 H), 7.74 (br d, 1 H), 7.60 (s, 1 H), 7.38-7.45 (m, 1 H), 6.30-7.15 (m, 3 H), 4.48 (br s, 1 H), 3.73 (br s, 1 H), 3.00 (br s, 1 H), 2.65-2.75 (m, 1 H) 529.1 [M+H] + 98.2%
1551 (DMSO- d 6) δ 12.05 (br s, 1 H), 9.50 (s, 1 H), 9.03 (br s, 1 H), 8.39-8.79 (m, 2 H), 8.12-8.26 (m, 2 H), 7.89-8.07 (m, 2 H), 7.74 (br d, 1 H), 7.60 (s, 1 H), 7.34-7.47 (m, 1 H), 6.26-7.21 (m, 3 H), 4.50 (br s, 1 H), 3.75 (s, 1 H), 3.00 (br s, 1 H), 2.71 (br d, 1 H) 529.1 [M+H] + 91.5%
1552 (DMSO- d 6) δ 12.05 (br s, 1 H), 8.93-9.18 (m, 2 H), 8.25-8.53 (m, 2 H), 7.88-8.07 (m, 2 H), 7.67-7.80 (m, 2 H), 7.59 (s, 1 H), 6.32-7.10 (m, 3 H), 4.51 (br s, 1 H), 3.88 (s, 3 H), 3.70 (s, 1 H), 2.99 (br s, 1 H), 2.66-2.73 (m, 1 H) 532.3 [M+H] + 100%
1553 (DMSO- d 6) δ 12.05 (br s, 1 H), 8.88-9.19 (m, 2 H), 8.29 (s, 2 H), 7.90-8.07 (m, 2 H), 7.67-7.80 (m, 2 H), 7.59 (s, 1 H), 6.21-7.14 (m, 3 H), 4.51 (br s, 1 H), 3.88 (s, 3 H), 3.70 (br s, 1 H), 2.99 (br s, 1 H), 2.70 (br d, 1 H) 532.2 [M+H]+ 99.8%
1554 (CD 3OD) δ 7.67-7.74 (m, 1 H), 7.41-7.53 (m, 1.3 H), 7.16-7.31 (m, 1 H), 6.95 (s, 0.7 H), 6.79 (d, 0.7 H), 6.59-6.69 (m, 1.3 H), 5.01 (br dd, 1 H), 3.73-3.84 (m, 0.7 H), 3.34-3.44 (m, 1.3 H), 2.91-3.22 (m, 1 H), 2.77-2.89 (m, 1 H), 1.45 (d, 6 H) 396.2 [M+H] + 100%
1555 (CD 3OD) δ 7.67-7.73 (m, 1 H), 7.41-7.52 (m, 1.3 H), 7.19-7.31 (m, 1 H), 6.95 (s, 0.7 H), 6.76-6.82 (m, 0.7 H), 6.59-6.69 (m, 1.3 H), 4.95-5.06 (m, 1 H), 3.73-3.85 (m, 0.7 H), 3.34-3.44 (m, 1.3 H), 2.94-3.22 (m, 1 H), 2.78-2.90 (m, 1 H), 1.46 (d, 6 H) 396.2 [M+H] + 99.5%
1556 (CD 3OD) δ 8.13-8.40 (m, 1 H), 7.35-7.78 (m, 1 H), 6.44-7.12 (m, 4 H), 4.97 (br dd, 1 H), 3.69-3.93 (m, 1.6 H), 3.39 (td, 0.4 H), 2.72-3.21 (m, 2 H), 2.31-2.61 (m, 7 H), 1.97-2.28 (m, 2 H) 404.2 [M+H] + 100%
1557 (CD 3OD) δ 8.14-8.40 (m, 1 H), 7.42-7.85 (m, 1 H), 6.35-7.18 (m, 4 H), 4.96 (br dd, 1 H), 3.68-3.92 (m, 1.6 H), 3.38 (td, 0.4 H), 2.77-3.21 (m, 2 H), 2.32-2.69 (m, 7 H), 1.89-2.31 (m, 2 H) 404.2 [M+H] + 95.9%
1558 (CD 3OD) δ 8.21-8.43 (m, 1 H), 7.69 (s, 1 H), 6.59-7.11 (m, 4 H), 4.99 (br dd, 1 H), 3.66-3.92 (m, 1.6 H), 3.34-3.42 (m, 0.4 H), 2.77-3.21 (m, 2 H), 2.40-2.60 (m, 4 H), 1.95-2.27 (m, 2 H) 408.2 [M+H] + 100%
1559 (CD 3OD) δ 8.24-8.43 (m, 1 H), 7.38-7.83 (m, 1 H), 6.60-7.07 (m, 4 H), 5.00 (br dd, 1 H), 3.71-3.94 (m, 1.6 H), 3.34-3.43 (m, 0.4 H), 2.76-3.22 (m, 2 H), 2.39-2.60 (m, 4 H), 2.00-2.25 (m, 2 H) 408.2 [M+H] + 98.5%
1560 (CD 3OD) δ 7.42-7.71 (m, 2 H), 6.56-7.27 (m, 4 H), 5.00 (br dd, 1 H), 3.76-3.97 (m, 1.6 H), 3.34-3.41 (m, 0.4 H), 2.78-3.21 (m, 2 H), 2.40-2.60 (m, 4 H), 1.95-2.28 (m, 2 H) 424.2 [M+H] + 100%
1561 (CD 3OD) δ 7.41-7.72 (m, 2 H), 6.59-7.23 (m, 4 H), 5.00 (br dd, 1 H), 3.76-3.94 (m, 1.6 H), 3.34-3.43 (m, 0.4 H), 2.77-3.20 (m, 2 H), 2.40-2.57 (m, 4 H), 1.95-2.27 (m, 2 H) 424.1 [M+H] + 98.7%
1562 (CD 3OD) δ 7.68 (d, 1 H), 7.35-7.51 (m, 1.4 H), 7.11 (dt, 1 H), 6.95 (s, 0.6 H), 6.39-6.75 (m, 2 H), 4.96 (br dd, 1 H), 3.79-3.99 (m, 1.6 H), 3.34-3.43 (m, 0.4 H), 2.75-3.20 (m, 2 H), 2.38-2.71 (m, 7 H), 1.94-2.32 (m, 2 H) 404.2 [M+H] + 100%
1563 (CD 3OD) δ 7.69 (d, 1 H), 7.36-7.51 (m, 1.4 H), 7.10 (dt, 1 H), 6.95 (s, 0.6 H), 6.31-6.80 (m, 2 H), 4.96 (br dd, 1 H), 3.77-3.98 (m, 1.5 H), 3.32-3.41 (m, 0.5 H), 2.76-3.20 (m, 2 H), 2.39-2.73 (m, 7 H), 1.94-2.29 (m, 2 H) 404.2 [M+H] + 94.5%
1564 (CD 3OD) δ 7.66-7.80 (m, 1 H), 7.41-7.61 (m, 1.3 H), 7.18-7.32 (m, 1 H), 6.98 (s, 0.7 H), 6.70-6.86 (m, 2 H), 6.61-6.70 (m, 1 H), 5.06 (br dd, 0.8 H), 3.92 (s, 3 H), 3.41-3.88 (m, 1.2 H), 3.20 (br d, 1 H), 2.86 (br dd, 1 H), 2.41 (s, 3 H) 448.1 [M+H] + 100%
1565 (CD 3OD) δ 7.71 (s, 1 H), 7.41-7.60 (m, 1.4 H), 7.20-7.31 (m, 1 H), 6.98 (s, 0.6 H), 6.70-6.84 (m, 2 H), 6.60-6.70 (m, 1 H), 5.06 (br dd, 1 H), 3.92 (s, 3 H), 3.42-3.88 (m, 1 H), 2.94-3.27 (m, 1 H), 2.86 (br dd, 1 H), 2.41 (s, 3 H) 448.1 [M+H] + 99.6%
1566 (CD 3OD) δ 8.30 (br s, 1 H), 7.64-7.82 (m, 1 H), 7.58 (br s, 0.3 H), 7.37-7.54 (m, 1 H), 7.13-7.34 (m, 1 H), 6.97 (s, 0.7 H), 6.70-6.85 (m, 1 H), 6.60-6.70 (m, 1 H), 4.97-5.17 (m, 1 H), 3.94 (s, 3 H), 3.39-3.86 (m, 1 H), 2.96-3.25 (m, 1 H), 2.78-2.93 (m, 1 H), 2.47-2.61 (m, 3 H) 448.2 [M+H] + 100%
1567 (CD 3OD) δ 8.30 (s, 1 H), 7.71 (s, 1 H), 7.58 (s, 0.3 H), 7.42-7.54 (m, 1 H), 7.19-7.33 (m, 1 H), 6.97 (s, 0.7 H), 6.70-6.85 (m, 1 H), 6.61-6.70 (m, 1 H), 5.02-5.18 (m, 1 H), 3.94 (s, 3 H), 3.42-3.88 (m, 1 H), 2.94-3.26 (m, 1 H), 2.79-2.93 (m, 1 H), 2.49-2.62 (m, 3 H) 448.2 [M+H] + 100%
1568 (CD 3OD) δ 8.53-8.64 (m, 1 H), 7.72 (s, 1 H), 7.41-7.56 (m, 2 H), 6.73-7.15 (m, 4 H), 4.95-5.17 (m, 1 H), 4.16-4.27 (m, 3 H), 3.75-3.88 (m, 0.5 H), 3.42 (td, 0.5 H), 2.85-3.26 (m, 2 H), 2.29-2.44 (m, 3 H) 480.2 [M+H] + 100%
1569 (CD 3OD) δ 8.54-8.64 (m, 1 H), 7.77 (br d, 1 H), 7.43-7.55 (m, 2 H), 6.78-7.17 (m, 4 H), 4.95-5.16 (m, 1 H), 4.20-4.27 (m, 3 H), 3.74-3.89 (m, 0.5 H), 3.39-3.49 (m, 0.5 H), 2.85-3.25 (m, 2 H), 2.33-2.46 (m, 3 H) 480.1 [M+H] + 97.3%
1570 (CD 3OD) δ 9.11-9.18 (m, 1 H), 8.46-8.62 (m, 2 H), 7.72 (s, 1 H), 7.40-7.62 (m, 1.4 H), 6.91-7.16 (m, 2.6 H), 6.75-6.88 (m, 1 H), 4.95-5.13 (m, 1 H), 3.74-3.84 (m, 0.7 H), 3.39-3.47 (m, 0.3 H), 2.95-3.26 (m, 1 H), 2.80-2.92 (m, 1 H) 520.1 [M+H] + 99.3%
1571 (CD 3OD) δ 8.97-9.07 (m, 1 H), 8.32-8.52 (m, 2 H), 7.60 (s, 1 H), 7.28-7.49 (m, 1.4 H), 6.76-7.06 (m, 2.6 H), 6.62-6.74 (m, 1 H), 4.82-5.03 (m, 1 H), 3.62-3.72 (m, 0.7 H), 3.26-3.35 (m, 0.3 H), 2.83-3.14 (m, 1 H), 2.67-2.81 (m, 1 H) 520.1 [M+H] + 99.5%
1572 (CD 3OD) δ 7.08-7.90 (m, 6 H), 6.53-6.99 (m, 1 H), 4.96-5.06 (m, 1 H), 3.76-3.97 (m, 1.6 H), 3.34 (br s, 0.4 H), 2.77-3.16 (m, 2 H), 2.36-2.63 (m, 4 H), 1.92-2.28 (m, 2 H) 440.1 [M+H] + 97.5%
1573 (CD 3OD) δ 7.08-7.81 (m, 5 H), 6.52-6.99 (m, 2 H), 4.91-5.03 (m, 1 H), 3.75-3.95 (m, 1.6 H), 3.32-3.39 (m, 0.4 H), 2.74-3.19 (m, 2 H), 2.42-2.57 (m, 4 H), 1.94-2.26 (m, 2 H) 440.1 [M+H] + 98.2%
1574 (CD 3OD) δ 7.61-7.75 (m, 1 H), 7.37-7.52 (m, 1 H), 7.17-7.30 (m, 1 H), 6.45-7.13 (m, 3 H), 5.00 (dd, 1 H), 3.73-3.94 (m, 1.6 H), 3.33-3.43 (m, 0.4 H), 2.74-3.21 (m, 2 H), 2.37-2.61 (m, 4 H), 1.94-2.29 (m, 2 H) 408.1 [M+H] + 100%
1575 (CD 3OD) δ 7.62-7.74 (m, 1 H), 7.20-7.52 (m, 2 H), 6.58-6.98 (m, 3 H), 4.91-5.05 (m, 1 H), 3.65-3.98 (m, 1.7 H), 3.35-3.43 (m, 0.3 H), 2.75-3.22 (m, 2 H), 2.41-2.57 (m, 4 H), 1.95-2.28 (m, 2 H) 408.2 [M+H] + 99.7%
1576 (CD 3OD) δ 8.43 (d, 1 H), 7.66 (s, 1 H), 7.57 (d, 1 H), 7.39 (d, 1 H), 7.31 (d, 1 H), 7.14-7.22 (m, 2 H), 7.03-7.11 (m, 1 H), 6.83 (t, 1 H), 6.60 (d, 2 H), 4.54 (dd, 1 H), 3.72 (td, 1 H), 2.98-3.11 (m, 1 H), 2.81 (dd, 1 H) 357.1 [M+H] + 100%
1577 (CD 3OD) δ 8.43 (br d, 1 H), 7.66 (s, 1 H), 7.57 (br d, 1 H), 7.39 (d, 1 H), 7.31 (d, 1 H), 7.13-7.23 (m, 2 H), 7.07 (t, 1 H), 6.83 (br t, 1 H), 6.50-6.66 (m, 2 H), 4.54 (dd, 1 H), 3.61-3.81 (m, 1 H), 2.94-3.12 (m, 1 H), 2.81 (br dd, 1 H) 357.2 [M+H] + 99.5%
1578 (CD 3OD) δ 8.45 (dd, 1 H), 8.26 (dd, 1 H), 7.68-7.81 (m, 2 H), 7.38-7.64 (m, 2 H), 6.99-7.34 (m, 3 H), 6.61-6.83 (m, 1 H), 4.97-5.07 (m, 1 H), 4.00 (d, 3.6 H), 3.37-3.42 (m, 0.4 H), 2.84-3.25 (m, 2 H) 493.1 [M+H] + 100%
1579 (CD 3OD) δ 8.34 (dd, 1 H), 8.15 (dd, 1 H), 7.57-7.68 (m, 2 H), 7.27-7.52 (m, 2 H), 6.86-7.20 (m, 3 H), 6.48-6.70 (m, 1 H), 4.83-4.94 (m, 1 H), 3.78-3.90 (m, 3.6 H), 3.24-3.29 (m, 0.4 H), 2.73-3.10 (m, 2 H) 493.1 [M+H] + 99.7%
1580 (CD 3OD) δ 8.51-8.59 (m, 1 H), 7.79-7.91 (m, 1 H), 7.57-7.70 (m, 3 H), 6.86-7.48 (m, 4 H), 6.46-6.72 (m, 1 H), 4.83-4.93 (m, 1 H), 3.76-3.87 (m, 0.5 H), 3.22-3.31 (m, 0.5 H), 2.73-3.15 (m, 2 H) 481.1 [M+H] + 99.1%
1581 (CD 3OD) δ 8.61-8.72 (m, 1 H), 7.91-8.00 (m, 1 H), 7.68-7.82 (m, 3 H), 6.99-7.60 (m, 4 H), 6.56-6.86 (m, 1 H), 4.95-5.02 (m, 1 H), 3.85-4.02 (m, 0.5 H), 3.36-3.45 (m, 0.5 H), 2.83-3.27 (m, 2 H) 481.1 [M+H] + 97.5%
1582 (CD 3OD) δ 8.28 (s, 1 H), 7.68-7.81 (m, 2 H), 7.35-7.60 (m, 1 H), 6.95-7.33 (m, 3 H), 6.57-6.81 (m, 1 H), 4.94-5.14 (m, 1 H), 3.93 (d, 3.5 H), 3.34-3.44 (m, 0.5 H), 2.82-3.25 (m, 2 H), 2.51-2.58 (m, 3 H) 480.2 [M+H] + 98.6%
1583 (CD 3OD) δ 8.15 (s, 1 H), 7.54-7.68 (m, 2 H), 7.23-7.48 (m, 1 H), 6.84-7.19 (m, 3 H), 6.51-6.68 (m, 1 H), 4.82-5.04 (m, 1 H), 3.80 (d, 3.5 H), 3.22-3.31 (m, 0.5 H), 2.72-3.07 (m, 2 H), 2.41 (d, 3 H) 480.2 [M+H] + 98.5%
1584 (CD 3OD) δ 7.67-7.80 (m, 2 H), 7.35-7.59 (m, 2 H), 6.97-7.32 (m, 3 H), 6.65-6.81 (m, 1 H), 4.96-5.13 (m, 1 H), 4.23 (d, 3 H), 3.94 (ddd, 0.6 H), 3.37-3.44 (m, 0.4 H), 2.84-3.23 (m, 2 H), 2.37 (d, 3 H) 480.1 [M+H] + 100%
1585 (CD 3OD) δ 7.56-7.68 (m, 2 H), 7.23-7.47 (m, 2 H), 6.85-7.20 (m, 3 H), 6.54-6.69 (m, 1 H), 4.84-5.01 (m, 1 H), 4.09-4.16 (m, 3 H), 3.82 (ddd, 0.6 H), 3.25-3.33 (m, 0.4 H), 2.72-3.13 (m, 2 H), 2.25 (d, 3 H) 480.1 [M+H] + 96.4%
1586 (CD 3OD) δ 8.39-8.46 (m, 1 H), 7.69 (s, 1 H), 7.37-7.49 (m, 0.3 H), 7.26-7.32 (m, 1 H), 6.92 (br s, 0.7 H), 6.81-6.89 (m, 1 H), 6.68-6.75 (m, 1 H), 4.99 (br dd, 1 H), 3.67-3.82 (m, 1.7 H), 3.35-3.44 (m, 0.3 H), 2.94-3.20 (m, 5 H), 2.82 (br d, 1 H) 460.1 [M+H] + 100%
1587 (CD 3OD) δ 8.39-8.46 (m, 1 H), 7.69 (s, 1 H), 7.44 (s, 0.3 H), 7.26-7.32 (m, 1 H), 6.92 (s, 0.7 H), 6.82-6.88 (m, 1 H), 6.69-6.75 (m, 1 H), 4.99 (dd, 1 H), 3.68-3.81 (m, 1.7 H), 3.38 (td, 0.3 H), 2.97-3.19 (m, 5 H), 2.77-2.87 (m, 1 H) 460.1 [M+H] + 99.0%
1588 (CD 3OD) δ 8.29 (d, 1 H), 7.65 (s, 1 H), 6.97 (d, 1 H), 6.77 (t, 1 H), 6.50 (s, 1 H), 6.24 (br s, 1 H), 4.17 (dd, 1 H), 3.67 (ddd, 1 H), 2.95-3.08 (m, 1 H), 2.77 (dd, 1 H), 2.42 (s, 3 H), 1.99-2.16 (m, 1 H), 1.04-1.13 (m, 4 H) 362.2 [M+H] + 100%
1589 (CD 3OD) δ 8.28 (d, 1 H), 7.65 (s, 1 H), 6.96 (br d, 1 H), 6.76 (t, 1 H), 6.50 (s, 1 H), 6.24 (s, 1 H), 4.17 (dd, 1 H), 3.67 (ddd, 1 H), 2.95-3.06 (m, 1 H), 2.76 (dd, 1 H), 2.41 (s, 3 H), 2.01-2.12 (m, 1 H), 1.00-1.15 (m, 4 H) 362.2 [M+H] + 99.8%
1590 (CD 3OD) δ 8.68 (d, 1 H), 7.60-7.67 (m, 2 H), 6.98 (t, 1 H), 6.68 (s, 1 H), 6.27 (s, 1 H), 4.20 (dd, 1 H), 3.68 (ddd, 1 H), 2.96-3.06 (m, 1 H), 2.78 (dd, 1 H), 2.02-2.11 (m, 1 H), 1.00-1.16 (m, 4 H) 416.2 [M+H] + 98.7%
1591 (CD 3OD) δ 8.68 (d, 1 H), 7.59-7.67 (m, 2 H), 6.98 (t, 1 H), 6.68 (s, 1 H), 6.27 (br s, 1 H), 4.20 (dd, 1 H), 3.64-3.72 (m, 1 H), 2.95-3.06 (m, 1 H), 2.78 (br dd, 1 H), 2.01-2.11 (m, 1 H), 1.00-1.13 (m, 4 H) 416.2 [M+H] + 98.9%
1592 (CD 3OD) δ 8.29-8.53 (m, 3 H), 7.70-7.72 (m, 1 H), 7.64 (s, 1 H), 7.61-7.72 (m, 1 H), 7.56 (d, 1 H), 7.07-7.28 (m, 2 H), 6.83 (td, 1 H), 6.65 (t, 1 H), 6.54 (s, 1 H), 4.96-5.12 (m, 1 H), 3.40-3.56 (m, 1 H), 2.81-3.00 (m, 1 H), 2.70 (dd, 1 H) 318.2 [M+H] + 100%
1593 (CD 3OD) δ 8.32-8.53 (m, 3 H), 7.67 (s, 1 H), 7.56 (d, 1 H), 7.07-7.26 (m, 2 H), 6.83 (t, 1 H), 6.66 (t, 1 H), 6.54 (s, 1 H), 5.04 (br dd, 1 H), 3.39-3.55 (m, 1 H), 2.83-3.00 (m, 1 H), 2.70 (dd, 1 H) 318.1 [M+H] + 99.4%
1594 (CD 3OD) δ 7.92-8.04 (m, 1 H), 7.77-7.88 (m, 1 H), 7.55-7.69 (m, 2 H), 7.25-7.50 (m, 2 H), 6.85-7.22 (m, 3 H), 6.47-6.71 (m, 1 H), 4.85-4.96 (m, 1 H), 3.75-3.88 (m, 0.5 H), 3.24 (br d, 0.5 H), 2.71-3.13 (m, 2 H), 2.54 (br d, 3 H) 477.2 [M+H] + 100%
1595 (CD 3OD) δ 8.07-8.19 (m, 1 H), 7.95 (td, 1 H), 7.68-7.84 (m, 2 H), 7.39-7.61 (m, 2 H), 6.98-7.34 (m, 3 H), 6.60-6.88 (m, 1 H), 4.97-5.08 (m, 1 H), 3.86-3.99 (m, 0.5 H), 3.36-3.42 (m, 0.5 H), 2.85-3.24 (m, 2 H), 2.67 (d, 3 H) 477.2 [M+H] + 98.2%
1596 (CD 3OD) δ 9.01 (s, 1 H), 8.78 (br s, 2 H), 7.85-8.03 (m, 2 H), 7.56-7.75 (m, 3 H), 6.42-7.17 (m, 4 H), 4.65 (br s, 1 H), 3.96 (s, 3 H), 3.44-3.81 (m, 1 H), 3.03-3.16 (m, 1 H), 2.73-2.83 (m, 1 H) 532.2 [M+H] + 100%
1597 (CD 3OD) δ 9.01 (d, 1 H), 8.24-8.89 (m, 2 H), 7.86-8.04 (m, 2 H), 7.56-7.74 (m, 3 H), 6.37-7.09 (m, 4 H), 4.66 (br s, 1 H), 3.96 (s, 3 H), 3.46-3.83 (m, 1 H), 3.04-3.15 (m, 1 H), 2.79 (br d, 1 H) 532.2 [M+H] + 98.4%
1598 (CD 3OD) δ 8.23-8.37 (m, 1 H), 7.35-7.76 (m, 1.4 H), 6.90-7.07 (m, 1.6 H), 6.73-6.86 (m, 1 H), 6.52-6.69 (m, 1 H), 4.98 (dd, 1 H), 3.69-3.90 (m, 1.6 H), 3.36-3.47 (m, 0.4 H), 2.92-3.24 (m, 5 H), 2.84 (br dd, 1 H), 2.37-2.52 (m, 3 H) 440.1 [M+H] + 100%
1599 (CD 3OD) δ 8.22-8.38 (m, 1 H), 7.43-7.78 (m, 1.4 H), 6.91-7.06 (m, 1.6 H), 6.74-6.87 (m, 1 H), 6.53-6.70 (m, 1 H), 4.98 (br dd, 1 H), 3.69-3.87 (m, 1.6 H), 3.37-3.45 (m, 0.4 H), 2.92-3.27 (m, 5 H), 2.84 (br dd, 1 H), 2.37-2.54 (m, 3 H) 440.1 [M+H] + 99.3%
1600 (CD 3OD) δ 8.64-8.76 (m, 1 H), 7.71 (s, 1 H), 7.60-7.68 (m, 1 H), 7.47 (br s, 0.4 H), 6.92-7.06 (m, 1.6 H), 6.73-6.86 (m, 1 H), 4.94-5.10 (m, 1 H), 3.68-3.88 (m, 1.6 H), 3.36-3.46 (m, 0.4 H), 2.93-3.25 (m, 5 H), 2.76-2.91 (m, 1 H) 494.1 [M+H] + 100%
1601 (CD 3OD) δ 8.65-8.77 (m, 1 H), 7.72 (s, 1 H), 7.59-7.68 (m, 1 H), 7.47 (s, 0.4 H), 6.92-7.07 (m, 1.6 H), 6.73-6.85 (m, 1 H), 4.93-5.10 (m, 1 H), 3.69-3.87 (m, 1.6 H), 3.37-3.47 (m, 0.4 H), 2.94-3.25 (m, 5 H), 2.79-2.90 (m, 1 H) 494.1 [M+H] + 99.5%
1602 (CD 3OD) δ 8.51-8.70 (m, 1 H), 7.71 (s, 1 H), 7.45 (br d, 1.3 H), 6.73-7.16 (m, 3.7 H), 4.92-5.05 (m, 1 H), 3.68-3.89 (m, 1.5 H), 3.36-3.47 (m, 0.5 H), 2.70-3.23 (m, 6 H) 476.2 [M+H] + 100%
1603 (CD 3OD) δ 8.52-8.66 (m, 1 H), 7.71 (s, 1 H), 7.38-7.51 (m, 1.3 H), 6.72-7.19 (m, 3.7 H), 4.92-5.05 (m, 1 H), 3.69-3.86 (m, 1.5 H), 3.34-3.44 (m, 0.5 H), 2.82-3.22 (m, 6 H) 476.2 [M+H] + 99.5%
1604 (CD 3OD) δ 8.26-8.42 (m, 1 H), 7.71 (s, 1 H), 7.46 (s, 0.5 H), 6.67-7.05 (m, 3.5 H), 5.01 (dd, 1 H), 3.68-3.88 (m, 1.5 H), 3.41 (td, 0.5 H), 2.76-3.24 (m, 6 H) 444.2 [M+H] + 100%
1605 (CD 3OD) δ 8.16-8.30 (m, 1 H), 7.55-7.65 (m, 1 H), 7.34 (s, 0.5 H), 6.57-6.91 (m, 3.5 H), 4.89 (br dd, 1 H), 3.53-3.75 (m, 1.5 H), 3.29 (td, 0.5 H), 2.68-3.09 (m, 6 H) 444.1 [M+H] + 92.0%
1606 (CD 3OD) δ 8.56 (br d, 1 H), 7.65 (s, 1 H), 7.41 (br d, 1 H), 6.68-7.12 (m, 3 H), 6.26 (s, 1 H), 4.13-4.25 (m, 1 H), 3.56-3.75 (m, 1 H), 3.00 (br d, 1 H), 2.78 (dd, 1 H), 1.97-2.13 (m, 1 H), 0.99-1.12 (m, 4 H) 398.2 [M+H] + 93.1%
1607 (CD 3OD) δ 8.57 (d, 1 H), 7.66 (s, 1 H), 7.41 (br d, 1 H), 6.64-7.17 (m, 3 H), 6.27 (s, 1 H), 4.19 (dd, 1 H), 3.67 (ddd, 1 H), 2.94-3.07 (m, 1 H), 2.78 (dd, 1 H), 2.02-2.15 (m, 1 H), 0.96-1.16 (m, 4 H) 398.2 [M+H] + 98.1%
1608 (CD 3OD) δ 7.60-7.82 (m, 3 H), 7.35-7.59 (m, 1 H), 6.97-7.33 (m, 4 H), 6.62-6.85 (m, 1 H), 5.09 (br dd, 1 H), 4.33 (br d, 3 H), 3.86-4.02 (m, 0.6 H), 3.37-3.43 (m, 0.4 H), 2.84-3.25 (m, 2 H) 466.1 [M+H] + 100%
1609 (CD 3OD) δ 7.49-7.70 (m, 3 H), 7.24-7.47 (m, 1 H), 6.85-7.21 (m, 4 H), 6.49-6.70 (m, 1 H), 4.85-5.01 (m, 1 H), 4.21 (br d, 3 H), 3.73-3.89 (m, 0.6 H), 3.25-3.33 (m, 0.4 H), 2.73-3.13 (m, 2 H) 466.2 [M+H] + 95.3%
1610 (CD 3OD) δ 8.68 (d, 2 H), 8.12 (d, 1 H), 8.00 (td, 1 H), 7.84 (s, 1 H), 7.48-7.66 (m, 2 H), 6.76-7.03 (m, 2 H), 6.58 (s, 1 H), 4.48 (dd, 1 H), 3.80 (ddd, 1 H), 3.00-3.21 (m, 1 H), 2.87 (dd, 1 H) 453.2 [M+H] + 98.9%
1611 (CD 3OD) δ 8.57-8.78 (m, 2 H), 8.12 (d, 1 H), 8.00 (td, 1 H), 7.69 (s, 1 H), 7.49-7.64 (m, 2 H), 6.76-7.03 (m, 2 H), 6.55 (br s, 1 H), 4.47 (dd, 1 H), 3.80 (ddd, 1 H), 2.67-3.21 (m, 2 H) 453.2 [M+H] + 99.7%
1612 (CD 3OD) δ 8.69 (d, 1 H), 8.33 (d, 1 H), 8.13 (d, 1 H), 8.01 (td, 1 H), 7.70 (s, 1 H), 7.55 (dd, 1 H), 6.95 (dd, 1 H), 6.77-6.86 (m, 2 H), 6.54 (s, 1 H), 4.47 (dd, 1 H), 3.75-3.86 (m, 1 H), 3.03-3.16 (m, 1 H), 2.86 (br dd, 1 H) 403.2 [M+H] + 100%
1613 (CD 3OD) δ 8.68 (d, 1 H), 8.32 (d, 1 H), 8.12 (d, 1 H), 7.99 (td, 1 H), 7.71 (s, 1 H), 7.51-7.57 (m, 1 H), 6.94 (dd, 1 H), 6.75-6.84 (m, 2 H), 6.53 (s, 1 H), 4.45 (dd, 1 H), 3.75-3.86 (m, 1 H), 3.03-3.15 (m, 1 H), 2.84 (dd, 1 H) 403.2 [M+H] + 99.6%
1614 (CD 3OD) δ 8.12-9.01 (m, 2 H), 8.07 (d, 1 H), 7.86 (d, 1 H), 7.57-7.72 (m, 2 H), 7.42 (dd, 1 H), 6.41-7.07 (m, 3 H), 4.65 (br s, 1 H), 3.79-3.95 (m, 4 H), 3.40-3.78 (m, 1 H), 3.02-3.17 (m, 5 H), 2.77 (br d, 1 H) 537.3 [M+H] + 99.2%
1615 (CD 3OD) δ 8.12-8.93 (m, 2 H), 8.09 (d, 1 H), 7.86 (d, 1 H), 7.57-7.70 (m, 2 H), 7.44 (dd, 1 H), 6.43-7.08 (m, 3 H), 4.65 (br s, 1 H), 3.82-3.90 (m, 4 H), 3.38-3.80 (m, 1 H), 3.03-3.16 (m, 5 H), 2.78 (br d, 1 H) 537.2 [M+H] + 99.7%
1616 (CD 3OD) δ 8.42 (d, 2 H), 8.32 (d, 1 H), 7.65 (s, 1 H), 7.19 (s, 1 H), 6.95 (dd, 1 H), 6.72-6.82 (m, 1 H), 6.62-6.70 (m, 2 H), 5.03-5.13 (m, 1 H), 3.42-3.55 (m, 1 H), 2.83-2.99 (m, 1 H), 2.71 (br dd, 1 H) 336.1 [M+H] + 100%
1617 (CD 3OD) δ 8.41 (d, 2 H), 8.32 (d, 1 H), 7.64 (s, 1 H), 7.18 (s, 1 H), 6.94 (dd, 1 H), 6.75-6.84 (m, 1 H), 6.60-6.73 (m, 2 H), 5.06 (br dd, 1 H), 3.40-3.53 (m, 1 H), 2.82-2.97 (m, 1 H), 2.71 (br dd, 1 H) 336.2 [M+H] + 90.7%
1618 (CD 3OD) δ 8.41 (d, 2 H), 8.28 (br d, 1 H), 7.64 (s, 1 H), 7.20 (s, 1 H), 6.96 (d, 1 H), 6.75 (t, 1 H), 6.65 (t, 1 H), 6.53 (s, 1 H), 5.03 (br dd, 1 H), 3.47 (ddd, 1 H), 2.83-3.04 (m, 1 H), 2.70 (br dd, 1 H), 2.43 (s, 3 H) 332.2 [M+H] + 100%
1619 (CD 3OD) δ 8.28 (d, 2 H), 8.16 (br d, 1 H), 7.52 (s, 1 H), 7.08 (s, 1 H), 6.83 (br d, 1 H), 6.62 (t, 1 H), 6.52 (t, 1 H), 6.41 (s, 1 H), 4.91 (br dd, 1 H), 3.29-3.40 (m, 1 H), 2.72-2.86 (m, 1 H), 2.57 (br dd, 1 H), 2.30 (s, 3 H) 332.1 [M+H] + 97.3%
1620 (500 MHz, CD 3OD) δ 8.88 (s, 1 H), 8.05-8.80 (m, 2 H), 7.85-7.96 (m, 1 H), 7.77 (dd, 1 H), 7.51-7.64 (m, 2 H), 6.23-7.01 (m, 5 H), 4.52 (br s, 1 H), 3.81-3.89 (m, 3 H), 3.28-3.77 (m, 1 H), 2.91-3.04 (m, 1 H), 2.67 (br d, 1 H), 2.34 (s, 3 H) 478.2 [M+H] + 100%
1621 (500 MHz, CD 3OD) δ 9.01 (s, 1 H), 8.27-8.94 (m, 2 H), 8.01 (d, 1 H), 7.89 (dd, 1 H), 7.60-7.77 (m, 2 H), 6.39-7.09 (m, 5 H), 4.64 (br s, 1 H), 3.94-4.09 (m, 3 H), 3.43-3.89 (m, 1 H), 3.02-3.21 (m, 1 H), 2.79 (br d, 1 H), 2.38-2.61 (m, 3 H) 478.2 [M+H] + 98.8%
1622 (CD 3OD) δ 8.69 (d, 1 H), 8.43 (d, 1 H), 8.13 (d, 1 H), 8.00 (t, 1 H), 7.68 (s, 1 H), 7.54 (dd, 1 H), 7.28 (d, 1 H), 6.83 (t, 1 H), 6.76 (s, 1 H), 6.53 (br s, 1 H), 4.46 (dd, 1 H), 3.79 (td, 1 H), 2.99-3.17 (m, 1 H), 2.84 (br d, 1 H) 419.1 [M+H] + 100%
1623 (CD 3OD) δ 8.68 (d, 1 H), 8.43 (d, 1 H), 8.13 (d, 1 H), 8.00 (t, 1 H), 7.68 (s, 1 H), 7.44-7.57 (m, 1 H), 7.28 (d, 1 H), 6.82 (t, 1 H), 6.76 (s, 1 H), 6.53 (s, 1 H), 4.46 (dd, 1 H), 3.71-3.86 (m, 1 H), 3.02-3.17 (m, 1 H), 2.84 (dd, 1 H) 419.1 [M+H] + 99.0%
1624 (CD 3OD) δ 8.26-8.85 (m, 3 H), 7.97 (d, 1 H), 7.68 (s, 1 H), 7.43-7.52 (m, 1 H), 6.37-7.14 (m, 4 H), 4.63-4.87 (m, 1 H), 3.58 (s, 3 H), 3.03-3.18 (m, 1 H), 2.70-2.85 (m, 1 H), 2.47 (s, 3 H), 2.32 (s, 6 H) 455.3 [M+H] + 97.4%
1625 (CD 3OD) δ 8.24-9.00 (m, 3 H), 7.97 (d, 1 H), 7.68 (s, 1 H), 7.48 (dd, 1 H), 6.28-7.14 (m, 4 H), 4.64-4.88 (m, 1 H), 3.58 (s, 3 H), 3.00-3.16 (m, 1 H), 2.69-2.86 (m, 1 H), 2.46 (s, 3 H), 2.32 (s, 6 H) 455.3 [M+H] + 99.0%
1626 (CD 3OD) δ 8.61-8.82 (m, 1 H), 8.12 (d, 1 H), 7.99 (td, 1 H), 7.72 (dd, 1 H), 7.67 (s, 1 H), 7.54 (ddd, 1 H), 7.20-7.50 (m, 2 H), 7.16 (d, 1 H), 6.73 (s, 1 H), 6.53 (s, 1 H), 4.45 (dd, 1 H), 3.85 (ddd, 1 H), 3.01-3.15 (m, 1 H), 2.85 (dd, 1 H) 435.1 [M+H] + 100%
1627 (CD 3OD) δ 8.69 (br s, 1 H), 8.13 (br d, 1 H), 8.01 (br t, 1 H), 7.64-7.81 (m, 2 H), 7.55 (br s, 1 H), 7.21-7.50 (m, 2 H), 7.17 (br d, 1 H), 6.74 (s, 1 H), 6.54 (br d, 1 H), 4.46 (br dd, 1 H), 3.78-3.97 (m, 1 H), 3.01-3.22 (m, 1 H), 2.76-2.95 (m, 1 H) 435.2 [M+H] + 99.0%
1628 以上所提供之數據
1629 以上所提供之數據
1630 (CD 3OD) δ 8.24-8.97 (m, 3 H), 8.08 (s, 1 H), 7.85-8.03 (m, 2 H), 7.59-7.73 (m, 2 H), 6.41-7.11 (m, 4 H), 4.63 (br s, 1 H), 3.95 (s, 3 H), 3.39-3.83 (m, 1 H), 3.00-3.16 (m, 1 H), 2.77 (br d, 1 H), 2.44 (s, 3 H) 478.2 [M+H] + 100%
1631 (CD 3OD) δ 8.29-8.96 (m, 3 H), 8.11 (s, 1 H), 7.88-8.04 (m, 2 H), 7.63-7.77 (m, 2 H), 6.45-7.12 (m, 4 H), 4.69-4.86 (m, 1 H), 3.97 (s, 3 H), 3.05-3.16 (m, 1 H), 2.80 (br d, 1 H), 2.46 (s, 3 H) 478.2 [M+H] + 98.7%
1632 (CD 3OD) δ 9.03 (s, 1 H), 8.02 (d, 1 H), 7.90 (dd, 2 H), 7.63-7.76 (m, 2 H), 7.24-7.51 (m, 2 H), 6.76 (d, 2 H), 4.56-4.75 (m, 2 H), 3.98 (s, 3 H), 2.98-3.18 (m, 1 H), 2.78 (dd, 1 H) 532.2 [M+H] + 100%
1633 (CD 3OD) δ 9.03 (s, 1 H), 8.03 (d, 1 H), 7.91 (dd, 2 H), 7.63-7.82 (m, 2 H), 7.28-7.50 (m, 2 H), 6.77 (d, 2 H), 4.56-4.73 (m, 2 H), 3.98 (s, 3 H), 3.01-3.19 (m, 1 H), 2.80 (dd, 1 H) 532.2 [M+H] + 100%
1634 (CD 3OD) δ 8.22-9.20 (m, 3 H), 8.01 (d, 1 H), 7.71 (s, 1 H), 7.50 (dd, 1 H), 7.33 (d, 1 H), 6.89 (br t, 3 H), 4.62-4.72 (m, 1 H), 3.92 (s, 2 H), 3.37-3.60 (m, 1 H), 3.00-3.18 (m, 1 H), 2.80 (br dd, 1 H), 2.56 (s, 6 H) 475.2 [M+H] + 98.0%
1635 (CD 3OD) δ 8.23-9.22 (m, 3 H), 8.01 (d, 1 H), 7.71 (s, 1 H), 7.50 (dd, 1 H), 7.33 (d, 1 H), 6.89 (s, 3 H), 4.60-4.73 (m, 1 H), 3.94 (s, 2 H), 3.36-3.58 (m, 1 H), 3.02-3.18 (m, 1 H), 2.72-2.88 (m, 1 H), 2.58 (s, 6 H) 475.2 [M+H] + 100%
1636 (CD 3OD) δ 8.68 (d, 1 H), 8.28 (d, 1 H), 8.13 (d, 1 H), 8.00 (td, 1 H), 7.68 (s, 1 H), 7.54 (ddd, 1 H), 6.97 (d, 1 H), 6.76 (t, 1 H), 6.64 (s, 1 H), 6.52 (s, 1 H), 4.43 (dd, 1 H), 3.71-3.86 (m, 1 H), 3.01-3.15 (m, 1 H), 2.83 (br dd, 1 H), 2.42 (s, 3 H) 399.2 [M+H] + 99.6%
1637 (CD 3OD) δ 8.69 (d, 1 H), 8.29 (br d, 1 H), 8.13 (d, 1 H), 8.00 (td, 1 H), 7.68 (s, 1 H), 7.40-7.59 (m, 1 H), 6.97 (br d, 1 H), 6.77 (t, 1 H), 6.64 (s, 1 H), 6.52 (br s, 1 H), 4.44 (dd, 1 H), 3.69-3.86 (m, 1 H), 3.01-3.18 (m, 1 H), 2.84 (br dd, 1 H), 2.43 (s, 3 H) 399.2 [M+H] + 99.6%
1638 (CD 3OD) δ 8.68 (d, 1 H), 8.13 (d, 1 H), 8.00 (td, 1 H), 7.67 (s, 1 H), 7.52-7.62 (m, 2 H), 7.16 (dd, 1 H), 6.98-7.05 (m, 1 H), 6.76 (s, 1 H), 6.54 (s, 1 H), 4.45 (dd, 1 H), 3.87 (td, 1 H), 3.04-3.15 (m, 1 H), 2.85 (dd, 1 H) 419.1 [M+H]+ 100%
1639 (CD 3OD) δ 8.68 (d, 1 H), 8.13 (d, 1 H), 8.00 (td, 1 H), 7.67 (s, 1 H), 7.59 (d, 1 H), 7.54 (dd, 1 H), 7.16 (dd, 1 H), 7.01 (d, 1 H), 6.76 (s, 1 H), 6.54 (s, 1 H), 4.45 (dd, 1 H), 3.82-3.92 (m, 1 H), 3.03-3.15 (m, 1 H), 2.85 (dd, 1 H) 419.1 [M+H]+ 95.0%
1640 (CD 3OD) δ 8.68 (br d, 1 H), 8.12 (d, 1 H), 7.99 (td, 1 H), 7.74 (br s, 1 H), 7.54 (ddd, 1 H), 7.45 (d, 1 H), 7.09 (dd, 1 H), 6.87 (s, 1 H), 6.36-6.64 (m, 2 H), 4.43 (dd, 1 H), 3.74-3.99 (m, 1 H), 2.98-3.22 (m, 1 H), 2.85 (br d, 1 H), 2.56-2.67 (m, 3 H) 399.2 [M+H] + 98.5%
1641 (CD 3OD) δ 8.67 (d, 1 H), 8.11 (d, 1 H), 7.99 (td, 1 H), 7.66 (s, 1 H), 7.50-7.58 (m, 1 H), 7.44 (d, 1 H), 7.08 (dd, 1 H), 6.68 (d, 1 H), 6.45-6.61 (m, 2 H), 4.42 (dd, 1 H), 3.85 (td, 1 H), 2.98-3.15 (m, 1 H), 2.83 (br dd, 1 H), 2.60 (s, 3 H) 399.2 [M+H] + 96.8%
1642 (CD 3OD) δ 8.29 (d, 1 H), 7.68 (s, 1 H), 7.39 (d, 1 H), 7.31 (d, 1 H), 7.18 (td, 1 H), 7.03-7.12 (m, 1 H), 6.96 (d, 1 H), 6.76 (t, 1 H), 6.60 (d, 2 H), 4.54 (dd, 1 H), 3.73 (ddd, 1 H), 2.98-3.13 (m, 1 H), 2.82 (dd, 1 H), 2.42 (s, 3 H) 371.2 [M+H] + 99.7%
1643 (CD 3OD) δ 8.28 (d, 1 H), 7.67 (s, 1 H), 7.38 (d, 1 H), 7.31 (d, 1 H), 7.18 (td, 1 H), 7.04-7.11 (m, 1 H), 6.96 (d, 1 H), 6.75 (t, 1 H), 6.55-6.65 (m, 2 H), 4.54 (dd, 1 H), 3.73 (ddd, 1 H), 2.98-3.13 (m, 1 H), 2.82 (dd, 1 H), 2.42 (s, 3 H) 371.2 [M+H] + 98.0%
1644 (CD 3OD) δ 9.24 (s, 1 H), 8.75-8.96 (m, 1 H), 8.25-8.45 (s, 1 H), 7.99-8.10 (m, 2 H), 7.84-7.97 (m, 2 H), 7.72 (s, 1 H), 7.31-7.45 (m, 1 H), 6.49-7.09 (m, 4 H), 4.67-4.88 (m, 1 H), 3.37-3.96 (m, 1 H), 3.02-3.19 (m, 1 H), 2.78 (br dd, 1 H) 479.2 [M+H] + 99.3%
1645 (CD 3OD) δ 9.18 (s, 1 H), 8.24-8.59 (m, 4 H), 7.80-8.04 (m, 4 H), 7.25-7.37 (m, 1 H), 6.61-6.96 (m, 4 H), 4.58 (br s, 1 H), 3.30-3.68 (m, 1 H), 2.98-3.16 (m, 1 H), 2.78 (br dd, 1 H) 479.2 [M+H] + 99.1%
1646 (CD 3OD) δ 9.01 (s, 1 H), 8.16-8.90 (m, 2 H), 8.02 (d, 1 H), 7.90 (dd, 1 H), 7.60-7.74 (m, 2 H), 6.49-7.07 (m, 5 H), 4.62 (br s, 1 H), 3.97 (s, 3 H), 3.41-3.86 (m, 1 H), 3.00-3.22 (m, 1 H), 2.80 (br dd, 1 H) 482.2 [M+H] + 94.3%
1647 (CD 3OD) δ 9.02 (s, 1 H), 8.44 (br s, 2 H), 8.02 (dd, 1 H), 7.91 (dd, 1 H), 7.59-7.78 (m, 2 H), 6.49-7.15 (m, 5 H), 4.62 (s, 1 H), 3.98 (s, 3 H), 3.42-3.90 (m, 1 H), 3.02-3.21 (m, 1 H), 2.69-2.89 (m, 1 H) 482.2 [M+H] + 98.6%
1648 (CD 3OD) δ 9.27 (s, 1 H), 8.22-9.01 (m, 3 H), 7.89-8.11 (m, 4 H), 7.67 (s, 1 H), 7.29-7.45 (m, 1 H), 6.35-7.11 (m, 4 H), 4.64-4.79 (m, 1 H), 3.40-3.84 (m, 1 H), 3.02-3.18 (m, 1 H), 2.70-2.86 (m, 1 H), 2.44 (s, 3 H) 475.2 [M+H] + 96.4%
1649 (CD 3OD) δ 9.30 (s, 1 H), 8.23-9.07 (m, 3 H), 7.91-8.12 (m, 4 H), 7.70 (s, 1 H), 7.35-7.45 (m, 1 H), 6.45-7.06 (m, 4 H), 4.66-4.81 (m, 1 H), 3.39-4.00 (m, 1 H), 3.05-3.16 (m, 1 H), 2.80 (br d, 2 H), 2.37-2.52 (m, 3 H) 475.2 [M+H] + 97.5%
1650 (CD 3OD) δ 8.43-8.76 (m, 3 H), 7.98 (d, 1 H), , 7.68-7.69 (m, 1 H), 7.40-7.40 (m, 1 H), 7.33 (d, 1 H), 6.57-7.02 (m, 3 H), 4.94-5.07 (m, 1 H), 4.55 (s, 2 H), 3.40-3.78 (m, 4 H), 3.04-3.18 (m, 1 H), 2.80 (br dd, 1 H) 462.1 [M+H] + 96.2%
1651 (CD 3OD) δ 8.37-8.83 (m, 3 H), 7.91-8.02 (m, 1 H), 7.66-7.79 (m, 1 H), 7.41-7.49 (m, 1 H), 7.32 (d, 1 H), 6.56-6.99 (m, 3 H), 4.93-4.60-4.75 (m, 1 H), 4.54 (s, 2 H), 3.38-3.87 (m, 4 H), 3.03-3.16 (m, 1 H), 2.80 (br dd, 1 H) 462.1 [M+H] + 98.9%
1652 (CD 3OD) δ 8.51 (d, 1 H), 8.02 – 8.42 (d, 1 H),7.72 (s, 1 H), 7.52 (s, 0.3 H), 7.29 (d, 1 H), 6.97 (s, 0.7 H), 6.52 – 6.86 (m, 3 H),5.02-5.10 (m, 1 H), 3.91-4.01 (m, 3 H), 3.74-3.84 (m, 0.7 H), 3.38-3.46 (m, 0.3 H), 3.14-3.25 (m, 0.7 H), 3.02 (ddd, 0.3 H), 2.77-2.91 (m, 1 H) 500.1 [M+H] + 99.7%
1653 (CD 3OD) δ 8.50 (d, 1 H), 7.92 – 8.22 (d, 1 H),7.72 (s, 1 H), 7.50 (s, 0.3 H), 7.30 (d, 1 H), 6.97 (s, 0.7 H), 6.48 – 6.76 (m, 3 H),4.92-5.15 (m, 1 H), 3.94-4.06 (m, 3 H), 3.71-3.80 (m, 0.7 H), 3.35-3.43 (m, 0.3 H), 3.10-3.24 (m, 0.7 H), 3.03 (ddd, 0.3 H), 2.77-2.91 (m, 1 H) 500.1 [M+H] + 99.4%
1654 (CD 3OD) δ 8.36 (br d, 1 H), 7.71 (br s, 1 H), 7.46 (br s, 0.3 H), 7.18-7.28 (m, 0.2 H), 7.02-7.07 (m, 0.5 H), 6.95-7.02 (m, 1 H), 6.81-6.95 (m, 2 H), 6.63-6.79 (m, 1 H), 5.01 (br dd, 0.4 H), 4.85-4.87 (m, 0.6 H), 3.64-3.81 (m, 0.7 H), 3.37-3.42 (m, 0.3 H), 2.92-3.22 (m, 1 H), 2.85 (br s, 1 H), 2.27-2.38 (m, 1 H), 1.20-1.32 (m, 4 H) 442.1 [M+H] + 97.4%
1655 (CD 3OD) δ 8.28-8.51 (m, 1 H), 7.70 (s, 1 H), 7.46 (br s, 0.3 H), 7.18-7.26 (m, 0.2 H), 7.02-7.09 (m, 0.5 H), 6.95-7.02 (m, 1 H), 6.81-6.95 (m, 2 H), 6.65-6.77 (m, 1 H), 5.01 (br dd, 0.5 H), 4.84-4.87 (m, 0.5 H), 3.66-3.82 (m, 0.7 H), 3.38-3.44 (m, 0.3 H), 2.91-3.23 (m, 1 H), 2.83 (br d, 1 H), 2.28-2.42 (m, 1 H), 1.19-1.32 (m, 4 H) 442.2 [M+H] + 95.2%
1656 (CD 3OD) δ 8.63-8.69 (m, 1 H), 8.28-8.42 (m, 1 H), 7.89-8.00 (m, 1 H), 7.68-7.81 (m, 2 H), 7.20-7.50 (m, 0.7 H), 6.92-7.07 (m, 2 H), 6.74-6.90 (m, 2.3 H), 4.94-5.03 (m, 1 H), 3.81 (ddd, 0.7 H), 3.45 (td, 0.3 H), 2.98-3.29 (m, 1 H), 2.87 (br dd, 1 H) 497.1 [M+H] + 100%
1657 (CD 3OD) δ 8.50-8.59 (m, 1 H), 8.16-8.30 (m, 1 H), 7.83 (t, 1 H), 7.57-7.70 (m, 2 H), 7.05-7.40 (m, 0.7 H), 6.82-6.97 (m, 2 H), 6.60-6.81 (m, 2.3 H), 4.84-4.92 (m, 1 H), 3.63-3.75 (m, 0.7 H), 3.33 (td, 0.3 H), 2.85-3.17 (m, 1 H), 2.76 (br dd, 1 H) 497.1 [M+H] + 99.4%
1658 (CD 3OD) δ 8.30-8.40 (m, 1 H), 7.97-8.05 (m, 1 H), 7.71 (s, 1 H), 7.57 (s, 0.3 H), 7.19-7.25 (m, 0.2 H), 6.70-7.07 (m, 4.5 H), 4.94-5.17 (m, 1 H), 3.90 (s, 3 H), 3.72-3.83 (m, 0.7 H), 3.35-3.46 (m, 0.3 H), 2.96-3.26 (m, 1 H), 2.80-2.91 (m, 1 H), 2.63-2.73 (m, 3 H) 496.2 [M+H] + 98.9%
1659 (CD 3OD) δ 8.28-8.41 (m, 1 H), 7.96-8.06 (m, 1 H), 7.71 (s, 1 H), 7.57 (s, 0.3 H), 7.17-7.27 (m, 0.2 H), 6.68-7.09 (m, 4.5 H), 4.94-5.16 (m, 1 H), 3.90 (s, 3 H), 3.71-3.83 (m, 0.7 H), 3.36-3.47 (m, 0.3 H), 2.95-3.26 (m, 1 H), 2.78-2.92 (m, 1 H), 2.62-2.75 (m, 3 H) 496.2 [M+H] + 99.4%
1660 (CD 3OD) δ 8.89-9.00 (m, 1 H), 8.29-8.43 (m, 2 H), 7.49-7.87 (m, 2.3 H), 7.18-7.30 (m, 0.2 H), 6.66-7.09 (m, 4.5 H), 4.95-5.15 (m, 1 H), 3.73-3.86 (m, 0.7 H), 3.42 (td, 0.3 H), 2.95-3.27 (m, 1 H), 2.87 (br dd, 1 H) 518.1 [M+H] + 100%
1661 (CD 3OD) δ 8.77-8.85 (m, 1 H), 8.17-8.28 (m, 2 H), 7.37-7.73 (m, 2.3 H), 7.07-7.14 (m, 0.2 H), 6.55-6.96 (m, 4.5 H), 4.81-5.03 (m, 1 H), 3.61-3.72 (m, 0.7 H), 3.30 (td, 0.3 H), 2.83-3.14 (m, 1 H), 2.74 (br d, 1 H) 518.2 [M+H] + 100%
1662 (CD 3OD) δ 8.21-8.52 (m, 2 H), 7.84 (s, 0.3 H), 7.66-7.76 (m, 1.5 H), 7.48-7.59 (m, 0.5 H), 7.18-7.29 (m, 1.2 H), 6.94-7.08 (m, 2.2 H), 6.81-6.91 (m, 1.3 H), 6.70-6.79 (m, 1 H), 5.06 (dd, 0.8 H), 4.96 (br s, 0.2 H), 3.74-3.87 (m, 0.7 H), 3.43 (td, 0.3 H), 2.95-3.28 (m, 1 H), 2.87 (br d, 1 H) 518.1 [M+H] + 100%
1663 (CD 3OD) δ 8.27-8.48 (m, 2 H), 7.84 (s, 0.3 H), 7.71 (d, 1.4 H), 7.49-7.63 (m, 0.6 H), 7.19-7.28 (m, 1.2 H), 6.93-7.08 (m, 2.1 H), 6.80-6.91 (m, 1.3 H), 6.70-6.79 (m, 1 H), 5.06 (dd, 0.7 H), 4.96 (br s, 0.3 H), 3.74-3.88 (m, 0.7 H), 3.42 (br t, 0.3 H), 2.97-3.27 (m, 1 H), 2.87 (br d, 1 H) 518.2 [M+H] + 99.4%
1664 (CD 3OD) δ 8.30 (d, 3 H), 7.53 (s, 1 H), 7.01-7.20 (m, 2 H), 6.69 (t, 1 H), 6.47-6.61 (m, 2 H), 4.95 (br dd, 1 H), 3.35 (td, 1 H), 2.70-2.87 (m, 1 H), 2.59 (br dd, 1 H) 352.1 [M+H] + 99.0%
1665 (CD 3OD) δ 8.27-8.49 (m, 3 H), 7.64 (s, 1 H), 7.11-7.34 (m, 2 H), 6.81 (t, 1 H), 6.58-6.71 (m, 2 H), 5.06 (br dd, 1 H), 3.37-3.53 (m, 1 H), 2.81-2.99 (m, 1 H), 2.70 (br dd, 1 H) 352.1 [M+H] + 98.5%
1666 (CD 3OD) δ 8.79 (br d, 1 H), 8.22-8.66 (m, 2 H), 7.89 (d, 1 H), 7.63-7.72 (m, 2 H), 7.35 (dd, 1 H), 6.62-7.06 (m, 3 H), 4.61-4.72 (m, 1 H), 3.35-3.88 (m, 1 H), 3.05-3.14 (m, 1 H), 2.79 (br dd, 1 H), 2.41 (s, 3 H) 466.2 [M+H] + 98.8%
1667 (CD 3OD) δ 8.78 (br d, 1 H), 8.21-8.67 (m, 2 H), 7.89 (d, 1 H), 7.63-7.72 (m, 2 H), 7.34 (dd, 1 H), 6.60-7.09 (m, 3 H), 4.61-4.72 (m, 1 H), 3.36-3.85 (m, 1 H), 3.05-3.14 (m, 1 H), 2.79 (dd, 1 H), 2.40 (s, 3 H) 466.1 [M+H] + 98.5%
1668 (CD 3OD) δ 8.32-8.61 (m, 3 H), 7.89 (d, 1 H), 7.67 (s, 1 H), 7.32-7.35 (m, 1 H), 7.00 (d, 1 H), 6.49-6.83 (m, 3 H), 4.61-4.74 (m, 1 H), 3.40-3.75 (m, 1 H), 3.03-3.12 (m, 1 H), 2.78 (br dd, 1 H), 2.45 (s, 3 H), 2.40 (s, 3 H) 412.2 [M+H] + 98.6%
1669 (CD 3OD) δ 8.33-8.68 (m, 3 H), 7.90 (d, 1 H), 7.67 (s, 1 H), 7.34 (d, 1 H), 7.01 (d, 1 H), 6.43-6.89 (m, 3 H), 4.61-4.75 (m, 1 H), 3.35-3.79 (m, 1 H), 3.03-3.12 (m, 1 H), 2.78 (br dd, 1 H), 2.46 (s, 3 H), 2.40 (s, 3 H) 412.2 [M+H] + 96.8%
1670 (CD 3OD) δ 8.20-8.65 (m, 3 H), 7.89 (d, 1 H), 7.68 (s, 1 H), 7.33 (d, 1 H), 6.61-7.01 (m, 4 H), 4.63 (br dd, 1 H), 3.44-3.80 (m, 1 H), 3.04-3.15 (m, 1 H), 2.78 (br dd, 1 H), 2.40 (s, 3 H) 416.2 [M+H] + 98.5%
1671 (CD 3OD) δ 8.20-8.69 (m, 3 H), 7.89 (d, 1 H), 7.62-7.73 (m, 1 H), 7.34 (dd, 1 H), 6.60-7.03 (m, 4 H), 4.56-4.72 (m, 1 H), 3.37-3.80 (m, 1 H), 3.04-3.15 (m, 1 H), 2.79 (br dd, 1 H), 2.40 (s, 3 H) 416.2 [M+H] + 99.6%
1672 (CD 3OD) δ 8.43 (br s, 3 H), 7.87 (br d, 1 H), 7.66 (s, 1 H), 7.16-7.39 (m, 1 H), 6.49-7.03 (m, 4 H), 4.62-4.69 (m, 1 H), 3.40-3.96 (m, 1 H), 2.96-3.18 (m, 1 H), 2.77 (br d, 1 H), 1.89-2.14 (m, 1 H), 0.90-1.12 (m, 2 H), 0.61-0.83 (m, 2 H) 442.2 [M+H] + 96.1%
1673 (CD 3OD) δ 8.43 (s, 3 H), 7.87 (d, 1 H), 7.66 (s, 1 H), 7.21 (dd, 1 H), 6.41-7.08 (m, 4 H), 4.62-4.70 (m, 1 H), 3.42-3.97 (m, 1 H), 2.92-3.16 (m, 1 H), 2.77 (br d, 1 H), 1.83-2.18 (m, 1 H), 0.94-1.10 (m, 2 H), 0.67-0.88 (m, 2 H) 442.2 [M+H] + 99.5%
1674 (DMSO- d 6) δ 12.04 (br s, 1 H), 9.01 (br s, 1 H), 8.17-8.66 (m, 2 H), 7.52-7.87 (m, 3 H), 6.47-7.35 (m, 4 H), 4.33-4.66 (m, 1 H), 3.84 (s, 3 H), 3.16-3.32 (m, 1 H), 2.61-3.08 (m, 2 H) 482.1 [M+H] + 100%
1675 (DMSO- d 6) δ 12.04 (br s, 1 H), 9.01 (br s, 1 H), 8.24-8.62 (m, 2 H), 7.52-8.00 (m, 3 H), 6.34-7.35 (m, 4 H), 4.40-4.63 (m, 1 H), 3.84 (s, 3 H), 3.31-3.33 (m, 1 H), 2.57-3.07 (m, 2 H) 482.2 [M+H] + 100%
1676 (DMSO- d 6) δ 11.93-12.14 (m, 1 H), 8.88 (br s, 1 H), 8.51 (d, 2 H), 7.85 (d, 1 H), 7.39-7.61 (m, 2 H), 7.12-7.31 (m, 2 H), 6.97 (br s, 1 H), 6.49-6.79 (m, 2 H), 4.38-4.63 (m, 1 H), 3.85 (s, 4 H), 2.65-3.06 (m, 2 H) 464.2 [M+H] + 99.0%
1677 (DMSO- d 6) δ 11.89-12.99 (m, 1 H), 8.88 (br s, 1 H), 8.27-8.56 (m, 2 H), 7.62-7.91 (m, 2 H), 7.38-7.57 (m, 1 H), 7.09-7.34 (m, 2 H), 6.98 (br t, 1 H), 6.70 (br s, 2 H), 4.30-4.67 (m, 1 H), 3.85 (s, 4 H), 2.64-3.05 (m, 2 H) 464.2 [M+H] + 99.0%
1678 (CD 3OD) δ 8.28-8.94 (m, 2 H), 7.95 (t, 1 H), 7.62-7.86 (m, 2 H), 7.35-7.60 (m, 0.4 H), 7.10-7.34 (m, 1 H), 6.71-7.09 (m, 2.6 H), 5.01 (br dd, 1 H), 3.73-3.90 (m, 0.6 H), 3.42-3.49 (m, 0.4 H), 2.98-3.29 (m, 1 H), 2.88 (br d, 1 H) 515.1 [M+H] + 100%
1679 (CD 3OD) δ 8.18-8.76 (m, 2 H), 7.75-7.93 (m, 1 H), 7.50-7.74 (m, 2 H), 7.34 (br s, 0.4 H), 7.01-7.22 (m, 1 H), 6.51-7.00 (m, 2.6 H), 4.89 (br dd, 1 H), 3.59-3.81 (m, 0.6 H), 3.30-3.36 (m, 0.4 H), 2.86-3.17 (m, 1 H), 2.67-2.83 (m, 1 H) 515.1 [M+H] + 96.1%
1680 (CD 3OD) δ 9.48 (d, 1 H), 8.70-9.09 (m, 2 H), 8.35-8.63 (m, 1 H), 7.73 (s, 1 H), 7.51 (s, 0.4 H), 7.14-7.34 (m, 1 H), 6.76-7.02 (m, 2.6 H), 5.06 (br dd, 1 H), 3.72-3.92 (m, 0.6 H), 3.42-3.50 (m, 0.4 H), 2.98-3.30 (m, 1 H), 2.77-2.95 (m, 1 H) 498.1 [M+H] + 100%
1681 (CD 3OD) δ 9.09-9.84 (m, 1 H), 8.72-9.06 (m, 2 H), 8.29-8.67 (m, 1 H), 7.72 (s, 1 H), 7.51 (br s, 0.4 H), 7.11-7.37 (m, 1 H), 6.58-7.09 (m, 2.6 H), 5.06 (br dd, 1 H), 3.77-3.87 (m, 0.6 H), 3.45 (br dd, 0.4 H), 3.22 (br d, 1 H), 2.88 (br d, 1 H) 498.1 [M+H] + 99.6%
1682 (CD 3OD) δ 8.35-8.54 (m, 2 H), 8.06-8.15 (m, 1 H), 7.73 (s, 1 H), 7.59 (s, 0.3 H), 7.12-7.28 (m, 1 H), 6.73-7.03 (m, 2.7 H), 5.12 (br dd, 1 H), 4.02 (s, 3 H), 3.44-3.83 (m, 1 H), 2.83-3.25 (m, 2 H) 500.1 [M+H] + 100%
1683 (CD 3OD) δ 8.27-8.40 (m, 2 H), 7.96-8.02 (m, 1 H), 7.62 (s, 1 H), 7.47 (s, 0.3 H), 7.05-7.13 (m, 1 H), 6.62-6.86 (m, 2.7 H), 5.00 (br dd, 1 H), 3.90 (s, 3 H), 3.32-3.72 (m, 1 H), 2.70-3.12 (m, 2 H) 500.2 [M+H] + 99.7%
1684 (CD 3OD) δ 8.43-8.53 (m, 1 H), 7.96-8.03 (m, 1 H), 7.71-7.79 (m, 1 H), 7.59 (s, 0.3 H), 7.17-7.25 (m, 1 H), 6.76-6.99 (m, 2.7 H), 5.13 (br dd, 1 H), 3.90 (s, 3 H), 3.43-3.81 (m, 1 H), 2.84-3.24 (m, 2 H), 2.63-2.71 (m, 3 H) 514.2 [M+H] + 99.8%
1685 (CD 3OD) δ 8.32-8.40 (m, 1 H), 7.85-7.93 (m, 1 H), 7.61 (s, 1 H), 7.46 (s, 0.3 H), 7.06-7.13 (m, 1 H), 6.63-6.86 (m, 2.7 H), 5.01 (br dd, 1 H), 3.75-3.83 (m, 3 H), 3.32-3.68 (m, 1 H), 2.74-3.13 (m, 2 H), 2.52-2.61 (m, 3 H) 514.2 [M+H] + 99.2%
1686 (CD 3OD) δ 8.28-8.41 (m, 1 H), 7.71 (br s, 1 H), 7.01-7.48 (m, 1 H), 6.81-7.01 (m, 3 H), 6.61-6.78 (m, 1 H), 4.93-5.03 (m, 1 H), 3.69-3.79 (m, 0.6 H), 3.36-3.45 (m, 0.4 H), 2.93-3.22 (m, 1 H), 2.84 (br dd, 1 H), 1.43-1.58 (m, 9 H) 458.2 [M+H] + 100%
1687 (CD 3OD) δ 8.28-8.41 (m, 1 H), 7.71 (s, 1 H), 7.01-7.46 (m, 1 H), 6.80-7.01 (m, 3 H), 6.64-6.78 (m, 1 H), 4.92-5.03 (m, 1 H), 3.74 (ddd, 0.6 H), 3.40 (td, 0.4 H), 2.93-3.23 (m, 1 H), 2.84 (dd, 1 H), 1.41-1.58 (m, 9 H) 458.2 [M+H] + 99.5%
1688 (CD 3OD) δ 8.76-8.81 (m, 1 H), 8.28-8.41 (m, 2 H), 8.10 (td, 1 H), 7.64-7.74 (m, 2 H), 7.04-7.54 (m, 1 H), 6.72-7.04 (m, 4 H), 4.94-5.07 (m, 1 H), 3.81 (ddd, 0.7 H), 3.45 (td, 0.3 H), 2.96-3.29 (m, 1 H), 2.87 (br d, 1 H) 479.1 [M+H] + 98.7%
1689 (CD 3OD) δ 8.63-8.71 (m, 1 H), 8.16-8.29 (m, 2 H), 7.98 (td, 1 H), 7.51-7.65 (m, 2 H), 6.92-7.43 (m, 1 H), 6.61-6.92 (m, 4 H), 4.81-4.95 (m, 1 H), 3.69 (ddd, 0.7 H), 3.33 (td, 0.3 H), 2.86-3.16 (m, 1 H), 2.66-2.80 (m, 1 H) 479.1 [M+H] + 98.4%
1690 (DMSO- d 6) δ 12.00 (br s, 1 H), 8.68 (s, 2 H), 7.91 (d, 1 H), 7.34-7.65 (m, 3 H), 6.24-7.25 (m, 4 H), 4.33-4.68 (m, 1 H), 3.38-4.08 (m, 3 H), 2.84-3.05 (m, 1 H), 2.69 (br s, 4 H), 2.17 (s, 6 H) 455.2 [M+H] + 100%
1691 (DMSO- d 6) δ 12.00 (br s, 1 H), 8.68 (s, 2 H), 7.91 (br d, 1 H), 7.31-7.61 (m, 3 H), 6.43-7.23 (m, 4 H), 4.31-4.65 (m, 1 H), 3.44 (s, 3 H), 2.94 (br s, 1 H), 2.69 (br s, 4 H), 2.17 (s, 6 H) 455.2 [M+H] + 100%
1692 (CD 3OD) δ 8.54 (br d, 1 H), 8.29 (d, 2 H), 7.41-7.60 (m, 2 H), 7.08 (s, 1 H), 6.74-6.92 (m, 1 H), 6.38-6.66 (m, 2 H), 4.96 (br dd, 1 H), 3.27-3.48 (m, 1 H), 2.70-2.88 (m, 1 H), 2.59 (br dd, 1 H) 386.1 [M+H] + 100%
1693 (CD 3OD) δ 8.54 (br d, 1 H), 8.29 (d, 2 H), 7.40-7.58 (m, 2 H), 7.09 (s, 1 H), 6.82 (br t, 1 H), 6.44-6.62 (m, 2 H), 4.96 (br dd, 1 H), 3.25-3.44 (m, 1 H), 2.70-2.91 (m, 1 H), 2.59 (br dd, 1 H) 386.1 [M+H] + 97.0%
1694 (CD 3OD) δ 8.42 (s, 1 H), 8.37 (br d, 1 H), 7.86 (d, 1 H), 7.65 (s, 1 H), 7.19 (d, 1 H), 6.99 (br d, 1 H), 6.79 (br t, 1 H), 6.53 (br s, 1 H), 4.60 (br s, 1 H), 3.37-3.91 (m, 1 H), 2.98-3.11 (m, 1 H), 2.70-2.89 (m, 1 H), 2.44 (s, 3 H), 1.93-2.06 (m, 1 H), 0.95-1.06 (m, 2 H), 0.70-0.82 (m, 2 H) 438.2 [M+H] + 100%
1695 (CD 3OD) δ 8.42 (s, 1 H), 8.37 (br s, 1 H), 7.87 (d, 1 H), 7.65 (s, 1 H), 7.20 (dd, 1 H), 6.99 (d, 1 H), 6.79 (t, 1 H), 6.53 (br s, 1 H), 4.60 (s, 1 H), 3.48 (s, 1 H), 2.97-3.13 (m, 1 H), 2.63-2.85 (m, 1 H), 2.44 (s, 3 H), 1.89-2.12 (m, 1 H), 0.97-1.14 (m, 2 H), 0.73-0.86 (m, 2 H) 438.2 [M+H] + 98.7%
1696 (DMSO- d 6) δ 12.02 (br s, 1 H), 8.19-8.77 (m, 3 H), 7.85 (dd, 1 H), 7.56 (d, 1 H), 7.04-7.33 (m, 2 H), 6.50-6.95 (m, 3 H), 4.26-4.74 (m, 1 H), 3.84 (d, 4 H), 2.61-3.08 (m, 2 H) 432.2 [M+H] + 100%
1697 (DMSO- d 6) δ 11.94-12.13 (m, 1 H), 8.20-8.75 (m, 3 H), 7.85 (d, 1 H), 7.57 (s, 1 H), 7.06-7.31 (m, 2 H), 6.47-6.91 (m, 3 H), 4.29-4.72 (m, 1 H), 3.84 (s, 3 H), 3.25-3.33 (m, 1 H), 2.62-3.05 (m, 2 H) 432.2 [M+H] + 100%
1698 (DMSO- d 6) δ 12.02 (br s, 1 H), 8.74 (br d, 1 H), 8.51 (s, 2 H), 7.85 (d, 1 H), 7.18-7.65 (m, 3 H), 6.30-7.02 (m, 3 H), 4.36-4.68 (m, 1 H), 3.85 (s, 3 H), 3.30 (br s, 1 H), 2.59-3.06 (m, 2 H) 448.1 [M+H] + 97.5%
1699 (DMSO- d 6) δ 12.02 (br s, 1 H), 8.73 (br s, 1 H), 8.51 (s, 2 H), 7.85 (d, 1 H), 7.18-7.65 (m, 3 H), 6.40-6.95 (m, 3 H), 4.30-4.67 (m, 1 H), 3.85 (s, 3 H), 3.29-3.32 (m, 1 H), 2.57-3.07 (m, 2 H) 448.1 [M+H] + 93.6%
1700 (CD 3OD) δ 8.34-8.55 (m, 2 H), 8.15 (dd, 1 H), 7.79 (d, 1 H), 7.63 (s, 1 H), 7.56 (d, 1 H), 7.12-7.20 (m, 1 H), 6.75-6.91 (m, 2 H), 6.52 (s, 1 H), 4.69 (dd, 1 H), 3.62 (ddd, 1 H), 2.90-3.06 (m, 1 H), 2.75 (dd, 1 H) 318.2 [M+H] + 100%
1701 (CD 3OD) δ 8.25-8.53 (m, 2 H), 8.04 (dd, 1 H), 7.67 (d, 1 H), 7.51 (s, 1 H), 7.38-7.47 (m, 1 H), 7.06 (s, 1 H), 6.70 (s, 2 H), 6.40 (s, 1 H), 4.57 (dd, 1 H), 3.50 (ddd, 1 H), 2.78-2.93 (m, 1 H), 2.63 (dd, 1 H) 318.2 [M+H] + 100%
1702 (CD 3OD) δ 8.39-8.84 (m, 1 H), 7.67-7.93 (m, 2 H), 7.53 (s, 0.4 H), 7.14-7.37 (m, 1 H), 6.56-7.14 (m, 3.6 H), 5.06 (br dd, 1 H), 4.04 (s, 3 H), 3.79 (ddd, 0.6 H), 3.39-3.46 (m, 0.4 H), 3.21 (br t, 1 H), 2.75-2.94 (m, 1 H) 500.1 [M+H] + 100%
1703 (CD 3OD) δ 8.15-9.00 (m, 1 H), 7.68-7.98 (m, 2 H), 7.53 (br s, 0.4 H), 7.11-7.31 (m, 1 H), 6.59-7.09 (m, 3.6 H), 5.06 (br dd, 1 H), 4.05 (s, 3 H), 3.79 (br dd, 0.6 H), 3.42 (br s, 0.4 H), 3.21 (br s, 1 H), 2.86 (br d, 1 H) 500.1 [M+H] + 99.7%
1704 (CD 3OD) δ 8.22-8.82 (m, 2 H), 7.38-8.13 (m, 2.4 H), 7.11-7.37 (m, 2 H), 6.65-7.09 (m, 2.6 H), 5.07 (dd, 1 H), 3.76-3.84 (m, 0.6 H), 3.39-3.47 (m, 0.4 H), 3.22 (br s, 1 H), 2.78-2.94 (m, 1 H) 536.1 [M+H] + 100%
1705 (CD 3OD) δ 8.18-8.80 (m, 2 H), 7.41-8.03 (m, 2.4 H), 7.11-7.36 (m, 2 H), 6.65-7.07 (m, 2.6 H), 5.07 (br dd, 1 H), 3.76-3.85 (m, 0.6 H), 3.43 (td, 0.4 H), 2.96-3.29 (m, 1 H), 2.87 (br d, 1 H) 536.1 [M+H] + 100%
1706 (CD 3OD) δ 8.38-8.57 (m, 2 H), 7.72 (s, 1 H), 7.41-7.59 (m, 0.3 H), 7.12-7.33 (m, 2 H), 6.85-7.02 (m, 1.7 H), 6.73-6.83 (m, 1 H), 4.94-5.13 (m, 1 H), 3.73-3.88 (m, 0.6 H), 3.44 (td, 0.4 H), 2.96-3.25 (m, 1 H), 2.79-2.92 (m, 1 H) 554.2 [M+H] + 100%
1707 (CD 3OD) δ 8.42-8.56 (m, 2 H), 7.72 (s, 1 H), 7.53 (s, 0.3 H), 7.16-7.34 (m, 2 H), 6.86-7.03 (m, 1.7 H), 6.73-6.85 (m, 1 H), 4.95-5.12 (m, 1 H), 3.75-3.86 (m, 0.6 H), 3.44 (td, 0.4 H), 2.97-3.27 (m, 1 H), 2.79-2.93 (m, 1 H) 554.2 [M+H] + 100%
1708 (CD 3OD) δ 8.51 (d, 1 H), 8.25-8.42 (m, 1 H), 7.72 (s, 1 H), 7.40-7.59 (m, 0.3 H), 7.29 (d, 1 H), 7.17-7.25 (m, 0.2 H), 6.93-7.09 (m, 2.2 H), 6.80-6.91 (m, 1.3 H), 6.70-6.80 (m, 1 H), 4.95-5.12 (m, 1 H), 3.74-3.87 (m, 0.6 H), 3.43 (td, 0.4 H), 2.95-3.27 (m, 1 H), 2.87 (br d, 1 H) 536.1 [M+H] + 100%
1709 (CD 3OD) δ 8.39 (d, 1 H), 8.16-8.30 (m, 1 H), 7.60 (s, 1 H), 7.30-7.44 (m, 0.3 H), 7.17 (d, 1 H), 7.06-7.13 (m, 0.2 H), 6.80-6.97 (m, 2.2 H), 6.68-6.79 (m, 1.3 H), 6.57-6.68 (m, 1 H), 4.94 (br dd, 1 H), 3.63-3.73 (m, 0.6 H), 3.31 (td, 0.4 H), 2.85-3.15 (m, 1 H), 2.75 (br d, 1 H) 536.1 [M+H] + 99.6%
1710 (CD 3OD) δ 8.30 (d, 1 H), 7.68 (s, 1 H), 6.92-7.19 (m, 1.7 H), 6.67-6.91 (m, 1.3 H), 6.58 (s, 1 H), 6.39 (s, 1 H), 4.32 (dd, 1 H), 3.62-3.89 (m, 1 H), 2.98-3.16 (m, 1 H), 2.83 (br dd, 1 H), 2.44 (s, 3 H) 372.1 [M+H] + 100%
1711 (CD 3OD) δ 8.31 (d, 1 H), 7.68 (s, 1 H), 6.94-7.22 (m, 1.7 H), 6.70-6.92 (m, 1.3 H), 6.58 (s, 1 H), 6.39 (br s, 1 H), 4.32 (dd, 1 H), 3.78 (ddd, 1 H), 2.98-3.18 (m, 1 H), 2.84 (br dd, 1 H), 2.45 (s, 3 H) 372.2 [M+H] + 99.7%
1712 (CD 3OD) δ 8.29-8.96 (m, 3 H), 7.89 (d, 1 H), 7.68 (s, 1 H), 7.45 (br d, 1 H), 7.33 (d, 1 H), 6.63-7.16 (m, 4 H), 4.58-4.74 (m, 1 H), 3.39-3.82 (m, 1 H), 2.75-3.11 (m, 2 H), 2.40 (s, 3 H) 448.2 [M+H] + 100%
1713 (CD 3OD) δ 8.25-8.92 (m, 3 H), 7.89 (d, 1 H), 7.68 (s, 1 H), 7.45 (br d, 1 H), 7.34 (dd, 1 H), 6.60-7.15 (m, 4 H), 4.59-4.74 (m, 1 H), 3.35-3.79 (m, 1 H), 2.76-3.15 (m, 2 H), 2.40 (s, 3 H) 448.1 [M+H] + 99.5%
1714 (CD 3OD) δ 8.28-8.72 (m, 3 H), 7.89 (d, 1 H), 7.68 (s, 1 H), 7.28-7.35 (m, 2 H), 6.47-6.93 (m, 3 H), 4.62 (br s, 1 H), 3.38-3.84 (m, 1 H), 2.76-3.13 (m, 2 H), 2.39 (s, 3 H) 432.1 [M+H] + 100%
1715 (CD 3OD) δ 8.24-8.77 (m, 3 H), 7.89 (d, 1 H), 7.68 (s, 1 H), 7.28-7.36 (m, 2 H), 6.50-6.94 (m, 3 H), 4.58-4.72 (m, 1 H), 3.37 (br s, 1 H), 2.75-3.12 (m, 2 H), 2.39 (s, 3 H) 432.1 [M+H] + 99.7%
1716 (CD 3OD) δ 8.77 (br d, 1 H), 8.43 (s, 2 H), 7.86 (d, 1 H), 7.57-7.73 (m, 2 H), 7.21 (d, 1 H), 7.00 (br t, 1 H), 6.49-6.90 (m, 2 H), 4.57-4.68 (m, 1.6 H), 3.40-3.72 (m, 0.4 H), 2.98-3.15 (m, 1 H), 2.77 (br dd, 1 H), 1.91-2.12 (m, 1 H), 0.96-1.10 (m, 2 H), 0.67-0.85 (m, 2 H) 492.2 [M+H] + 98.0%
1717 (CD 3OD) δ 8.77 (br d, 1 H), 8.42 (s, 2 H), 7.86 (d, 1 H), 7.52-7.73 (m, 2 H), 7.21 (dd, 1 H), 7.00 (t, 1 H), 6.47-6.92 (m, 2 H), 4.59 (s, 1.5 H), 3.40-3.69 (m, 0.5 H), 2.97-3.17 (m, 1 H), 2.77 (br dd, 1 H), 1.92-2.09 (m, 1 H), 0.96-1.09 (m, 2 H), 0.71-0.83 (m, 2 H) 492.2 [M+H] + 98.1%
1718 (DMSO- d 6) δ 11.99 (br s, 1 H), 8.51 (d, 2 H), 7.86 (d, 1 H), 7.45-7.62 (m, 2 H), 7.08-7.29 (m, 2 H), 6.24-6.94 (m, 3 H), 4.35-4.71 (m, 1 H), 3.42-4.33 (m, 4 H), 2.86-3.01 (m, 1 H), 2.56-2.78 (m, 4 H) 428.2 [M+H] + 99.9%
1719 (DMSO- d 6) δ 11.99 (br s, 1 H), 8.51 (d, 2 H), 7.87 (d, 1 H), 7.55 (br s, 2 H), 7.10-7.32 (m, 2 H), 6.33-6.92 (m, 3 H), 4.51 (br d, 1 H), 3.53-4.28 (m, 4 H), 2.85-3.00 (m, 1 H), 2.69 (br s, 4 H) 428.2 [M+H] + 99.8%
1720 (DMSO- d 6) δ 12.02 (br s, 1 H), 8.08-8.84 (m, 2 H), 7.86 (br d, 1 H), 7.46-7.66 (m, 2 H), 7.24 (br d, 2 H), 6.34-7.02 (m, 3 H), 4.28-4.74 (m, 1 H), 3.54-4.26 (m, 4 H), 2.89-3.05 (m, 1 H), 2.69 (br d, 1 H) 432.2 [M+H] + 99.7%
1721 (DMSO- d 6) δ 11.84-12.18 (m, 1 H), 8.15-8.69 (m, 2 H), 7.86 (d, 1 H), 7.44-7.65 (m, 2 H), 7.15-7.38 (m, 2 H), 6.27-6.95 (m, 3 H), 4.49 (br d, 1 H), 3.85 (s, 4 H), 2.86-3.05 (m, 1 H), 2.63-2.76 (m, 1 H) 432.1 [M+H] + 98.5%
1722 (CD 3OD) δ 8.32-8.38 (m, 1 H), 8.02-8.13 (m, 1 H), 7.84 (s, 0.3 H), 7.71 (d, 1.5 H), 7.53 (d, 0.5 H), 7.21-7.27 (m, 1 H), 6.97 (s, 0.7 H), 6.75-6.84 (m, 1 H), 6.56-6.71 (m, 2 H), 4.97-5.08 (m, 1 H), 3.94-4.01 (m, 3 H), 3.74-3.84 (m, 0.5 H), 3.39-3.53 (m, 0.5 H), 3.13-3.26 (m, 0.8 H), 2.95-3.08 (m, 0.2 H), 2.81-2.91 (m, 1 H) 482.1 [M+H] + 99.6%
1723 (CD 3OD) δ 8.19-8.27 (m, 1 H), 7.89-8.03 (m, 1 H), 7.72 (s, 0.3 H), 7.54-7.63 (m, 1.5 H), 7.37-7.45 (m, 0.5 H), 7.08-7.14 (m, 1 H), 6.85 (s, 0.7 H), 6.63-6.72 (m, 1 H), 6.43-6.59 (m, 2 H), 4.84-4.94 (m, 1 H), 3.81-3.89 (m, 3 H), 3.61-3.73 (m, 0.6 H), 3.27-3.36 (m, 0.4 H), 3.02-3.15 (m, 0.7 H), 2.84-2.96 (m, 0.3 H), 2.69-2.81 (m, 1 H) 482.2 [M+H] + 98.7%
1724 (CD 3OD) δ 8.32-8.65 (m, 1 H), 7.70 (s, 1 H), 7.46 (br s, 0.3 H), 7.22 (br d, 1 H), 6.86-6.97 (m, 1.7 H), 6.69-6.79 (m, 1 H), 4.94-5.07 (m, 1 H), 3.74 (ddd, 0.6 H), 3.36-3.47 (m, 0.4 H), 2.83 (br d, 2 H), 2.29-2.38 (m, 1 H), 1.20-1.33 (m, 4 H) 460.2 [M+H] + 100%
1725 (CD 3OD) δ 8.38-8.56 (m, 1 H), 7.70 (s, 1 H), 7.47 (s, 0.3 H), 7.16-7.27 (m, 1 H), 6.83-6.99 (m, 1.7 H), 6.66-6.79 (m, 1 H), 5.02 (br dd, 1 H), 3.74 (ddd, 0.6 H), 3.35-3.45 (m, 0.4 H), 2.80-3.21 (m, 2 H), 2.26-2.39 (m, 1 H), 1.19-1.33 (m, 4 H) 460.2 [M+H] + 100%
1726 (CD 3OD) δ 8.39-8.57 (m, 1 H), 7.71 (s, 1 H), 7.41 (s, 0.3 H), 7.17-7.25 (m, 1 H), 6.88-6.98 (m, 1.7 H), 6.70-6.82 (m, 1 H), 4.99 (br dd, 1 H), 3.77 (ddd, 0.6 H), 3.40 (br d, 0.4 H), 2.85 (br dd, 2 H), 1.83-1.97 (m, 6 H) 480.1 [M+H] + 100%
1727 (CD 3OD) δ 8.39-8.56 (m, 1 H), 7.71 (s, 1 H), 7.41 (s, 0.3 H), 7.17-7.25 (m, 1 H), 6.88-6.98 (m, 1.7 H), 6.70-6.80 (m, 1 H), 4.94-5.03 (m, 1 H), 3.77 (ddd, 0.6 H), 3.40 (td, 0.4 H), 2.81-3.21 (m, 2 H), 1.78-2.01 (m, 6 H) 480.2 [M+H] + 99.4%
1728 (CD 3OD) δ 8.17-8.54 (m, 1 H), 7.72 (br s, 1 H), 7.42 (br s, 0.3 H), 7.18-7.25 (m, 0.2 H), 6.91-7.10 (m, 2 H), 6.80-6.90 (m, 1.3 H), 6.56-6.79 (m, 1.2 H), 4.98 (br dd, 1 H), 3.68-3.83 (m, 0.7 H), 3.37-3.46 (m, 0.3 H), 3.09-3.23 (m, 0.8 H), 2.99 (br d, 0.2 H), 2.85 (br d, 1 H), 1.75-2.00 (m, 6 H) 462.1 [M+H] + 100%
1729 (CD 3OD) δ 8.27-8.41 (m, 1 H), 7.71 (s, 1 H), 7.42 (s, 0.3 H), 7.18-7.26 (m, 0.2 H), 6.92-7.09 (m, 2.2 H), 6.82-6.90 (m, 1.3 H), 6.64-6.79 (m, 1 H), 4.98 (br dd, 1 H), 3.64-3.88 (m, 0.7 H), 3.38-3.44 (m, 0.3 H), 3.13-3.23 (m, 0.7 H), 2.94-3.06 (m, 0.3 H), 2.85 (dd, 1 H), 1.78-2.00 (m, 6 H) 462.2 [M+H] + 100%
1730 (CD 3OD) δ 8.62 (br d, 3 H), 7.96 (d, 1 H), 7.67 (br s, 1 H), 7.31-7.51 (m, 2 H), 6.49-7.20 (m, 5 H), 4.94-5.29 (m, 1 H), 3.33-3.92 (m, 1 H), 2.97-3.14 (m, 1 H), 2.78 (br d, 1 H) 434.1 [M+H] + 99.5%
1731 (CD 3OD) δ 8.62 (br d, 3 H), 7.96 (d, 1 H), 7.66 (s, 1 H), 7.36-7.51 (m, 2 H), 6.63-7.16 (m, 5 H), 4.93-5.21 (m, 1 H), 3.57 (br s, 1 H), 3.00-3.16 (m, 1 H), 2.77 (br dd, 1 H) 434.1 [M+H] + 99.8%
1732 (CD 3OD) δ 8.59 (d, 1 H), 7.69 (s, 1 H), 7.44 (br d, 1 H), 7.12 (d, 0.5 H), 6.90-7.05 (m, 2 H), 6.85 (d, 0.5 H), 6.76 (s, 1 H), 6.41 (br s, 1 H), 4.34 (dd, 1 H), 3.77 (ddd, 1 H), 2.99-3.17 (m, 1 H), 2.84 (br dd, 1 H) 408.1 [M+H] + 97.2%
1733 (CD 3OD) δ 8.59 (d, 1 H), 7.69 (s, 1 H), 7.44 (d, 1 H), 7.12 (d, 0.5 H), 6.90-7.04 (m, 2 H), 6.85 (d, 0.5 H), 6.76 (s, 1 H), 6.41 (s, 1 H), 4.35 (dd, 1 H), 3.77 (ddd, 1 H), 2.98-3.19 (m, 1 H), 2.84 (dd, 1 H) 408.1 [M+H] + 97.1%
1734 (CD 3OD) δ 8.70 (d, 1 H), 7.54-7.84 (m, 2 H), 6.93-7.21 (m, 1.7 H), 6.69-6.90 (m, 1.3 H), 6.42 (s, 1 H), 4.36 (dd, 1 H), 3.78 (ddd, 1 H), 3.07 (br d, 1 H), 2.85 (dd, 1 H) 426.1 [M+H] + 98.6%
1735 (CD 3OD) δ 8.58 (d, 1 H), 7.32-7.74 (m, 2 H), 6.81-7.05 (m, 1.7 H), 6.56-6.78 (m, 1.3 H), 6.30 (s, 1 H), 4.24 (dd, 1 H), 3.66 (ddd, 1 H), 2.96 (br s, 1 H), 2.73 (dd, 1 H) 426.1 [M+H] + 97.4%
1736 (CD 3OD) δ 8.35 (d, 1 H), 7.69 (s, 1 H), 7.12 (s, 0.3 H), 6.78-7.03 (m, 2.7 H), 6.72 (s, 1 H), 6.39 (s, 1 H), 4.34 (dd, 1 H), 3.78 (ddd, 1 H), 2.98-3.18 (m, 1 H), 2.84 (dd, 1 H) 376.1 [M+H] + 98.9%
1737 (CD 3OD) δ 8.35 (d, 1 H), 7.70 (s, 1 H), 7.12 (s, 0.3 H), 6.76-7.06 (m, 2.7 H), 6.72 (s, 1 H), 6.40 (s, 1 H), 4.34 (dd, 1 H), 3.78 (ddd, 1 H), 2.99-3.21 (m, 1 H), 2.84 (dd, 1 H) 376.1 [M+H] + 100%
1738 (CD 3OD) δ 8.45 (d, 1 H), 7.69 (s, 1 H), 7.31 (d, 1 H), 7.12 (s, 0.3 H), 6.99 (s, 0.5 H), 6.81-6.91 (m, 1.2 H), 6.71 (s, 1 H), 6.39 (br s, 1 H), 4.34 (dd, 1 H), 3.78 (ddd, 1 H), 2.98-3.15 (m, 1 H), 2.84 (br dd, 1 H) 392.1 [M+H] + 98.2%
1739 (CD 3OD) δ 8.45 (d, 1 H), 7.70 (s, 1 H), 7.30 (d, 1 H), 7.12 (s, 0.3 H), 6.99 (s, 0.5 H), 6.78-6.91 (m, 1.2 H), 6.71 (s, 1 H), 6.39 (s, 1 H), 4.34 (dd, 1 H), 3.78 (ddd, 1 H), 2.96-3.19 (m, 1 H), 2.84 (dd, 1 H) 392.1 [M+H] + 99.6%
1740 (CD 3OD) δ 7.66 (s, 1 H), 7.45 (d, 1 H), 6.82-7.15 (m, 2 H), 6.70 (d, 1 H), 6.50 (s, 1 H), 6.38 (s, 1 H), 4.31 (dd, 1 H), 3.78 (ddd, 1 H), 2.98-3.12 (m, 1 H), 2.82 (dd, 1 H), 2.62 (s, 3 H) 372.1 [M+H] + 98.9%
1741 (CD 3OD) δ 7.66 (s, 1 H), 7.44 (br d, 1 H), 6.82-7.16 (m, 2 H), 6.68 (br d, 1 H), 6.50 (s, 1 H), 6.38 (s, 1 H), 4.30 (dd, 1 H), 3.72-3.84 (m, 1 H), 3.03 (br d, 1 H), 2.81 (br dd, 1 H), 2.61 (s, 3 H) 372.2 [M+H] + 98.5%
1742 (CD 3OD) δ 8.30-8.76 (m, 3 H), 7.86 (d, 1 H), 7.66 (s, 1 H), 7.43 (br d, 1 H), 6.51-7.24 (m, 5 H), 4.62 (br d, 1 H), 3.39-3.70 (m, 1 H), 3.01-3.11 (m, 1 H), 2.77 (br dd, 1 H), 1.92-2.07 (m, 1 H), 0.97-1.07 (m, 2 H), 0.69-0.83 (m, 2 H) 474.2 [M+H] + 92.4%
1743 (CD 3OD) δ 8.30-8.76 (m, 3 H), 7.86 (d, 1 H), 7.66 (s, 1 H), 7.43 (br d, 1 H), 6.48-7.24 (m, 5 H), 4.62 (br s, 1 H), 3.39-3.75 (m, 1 H), 2.98-3.14 (m, 1 H), 2.77 (br dd, 1 H), 1.93-2.08 (m, 1 H), 0.94-1.08 (m, 2 H), 0.70-0.82 (m, 2 H) 474.2 [M+H] + 93.8%
1744 (CD 3OD) δ 8.62-9.24 (m, 1 H), 8.40 (s, 1 H), 7.88 (d, 1 H), 7.55-7.68 (m, 2 H), 7.13-7.24 (m, 2 H), 7.05 (d, 1 H), 6.45-6.94 (m, 2 H), 4.63 (br s, 1 H), 3.35-3.64 (m, 1 H), 2.98-3.11 (m, 1 H), 2.75 (dd, 1 H), 1.94-2.06 (m, 1 H), 0.97-1.07 (m, 2 H), 0.71-0.80 (m, 2 H) 458.2 [M+H] + 100%
1745 (CD 3OD) δ 8.52-9.28 (m, 1 H), 8.41 (s, 1 H), 7.88 (d, 1 H), 7.56-7.68 (m, 2 H), 6.98-7.25 (m, 3 H), 6.49-6.92 (m, 2 H), 4.61-4.72 (m, 1 H), 3.36-3.68 (m, 1 H), 2.96-3.12 (m, 1 H), 2.75 (dd, 1 H), 1.94-2.06 (m, 1 H), 0.96-1.08 (m, 2 H), 0.73-0.83 (m, 2 H) 458.2 [M+H] + 99.0%
1746 (CD 3OD) δ 8.77 (br d, 1 H), 8.35 (br s, 1 H), 7.92 (d, 1 H), 7.84 (d, 1 H), 7.57-7.71 (m, 2 H), 7.38 (dd, 1 H), 7.00 (t, 1 H), 6.59-6.92 (m, 2 H), 4.64 (br s, 1 H), 3.42-3.78 (m, 1 H), 3.02-3.16 (m, 1 H), 2.95 (s, 6 H), 2.71-2.83 (m, 1 H) 495.2 [M+H] + 100%
1747 (CD 3OD) δ 8.78 (br s, 1 H), 8.37 (br s, 1 H), 7.92 (d, 1 H), 7.84 (d, 1 H), 7.55-7.72 (m, 2 H), 7.39 (dd, 1 H), 7.00 (br t, 1 H), 6.56-6.92 (m, 2 H), 4.65 (br s, 1 H), 3.56 (br s, 1 H), 3.03-3.18 (m, 1 H), 2.95 (s, 6 H), 2.77 (br d, 1 H) 495.2 [M+H] + 99.8%
1748 (CD 3OD) δ 9.00 (s, 2 H), 8.15 (br d, 1 H), 7.99 (d, 1 H), 7.88 (d, 1 H), 7.61-7.69 (m, 2 H), 6.65-7.16 (m, 3 H), 6.58 (d, 2 H), 4.59 (br d, 1 H), 3.96 (s, 7 H), 3.07 (br d, 1 H), 2.72-2.83 (m, 1 H) 494.3 [M+H] + 98.4%
1749 (CD 3OD) δ 8.95 (br d, 2 H), 8.13 (br s, 1 H), 7.96 (br d, 1 H), 7.73-7.90 (m, 1 H), 7.57-7.72 (m, 2 H), 6.61-7.20 (m, 3 H), 6.54 (br d, 2 H), 4.59 (br s, 1 H), 3.41-3.98 (m, 7 H), 2.92-3.18 (m, 1 H), 2.76 (br d, 1 H) 494.2 [M+H] + 99.2%
1750 (CD 3OD) δ 8.37 (br d, 2 H), 7.92 (d, 1 H), 7.85 (d, 1 H), 7.65 (s, 1 H), 7.38 (dd, 1 H), 6.99 (d, 1 H), 6.38-6.91 (m, 3 H), 4.63-4.71 (m, 1 H), 3.58 (br s, 1 H), 3.00-3.16 (m, 1 H), 2.95 (s, 6 H), 2.76 (br d, 1 H), 2.44 (s, 3 H) 441.2 [M+H] + 100%
1751 (CD 3OD) δ 8.37 (br d, 2 H), 7.91 (d, 1 H), 7.84 (d, 1 H), 7.65 (s, 1 H), 7.38 (dd, 1 H), 6.99 (d, 1 H), 6.43-6.91 (m, 3 H), 4.61-4.70 (m, 1 H), 3.56 (br s, 1 H), 3.00-3.14 (m, 1 H), 2.95 (s, 6 H), 2.76 (br d, 1 H), 2.44 (s, 3 H) 441.2 [M+H] + 100%
1752 (CD 3OD) δ 8.64 (s, 2 H), 8.40 (d, 1 H), 7.44-7.72 (m, 2 H), 7.07-7.30 (m, 2 H), 6.80 (td, 1 H), 6.54 (s, 1 H), 5.15 (dd, 1 H), 3.42-3.60 (m, 1 H), 2.58-3.02 (m, 2 H) 386.1 [M+H] + 100%
1753 (CD 3OD) δ 8.63 (s, 2 H), 8.39 (dd, 1 H), 7.63 (s, 1 H), 7.53 (d, 1 H), 7.23 (s, 1 H), 7.14 (ddd, 1 H), 6.80 (td, 1 H), 6.45-6.61 (m, 1 H), 5.14 (dd, 1 H), 3.50 (td, 1 H), 2.71-2.99 (m, 2 H) 386.2 [M+H] + 99.5%
1754 (CD 3OD) δ 8.65 (s, 2 H), 8.26 (d, 1 H), 7.65 (s, 1 H), 7.24 (s, 1 H), 6.95 (d, 1 H), 6.74 (t, 1 H), 6.54 (s, 1 H), 5.16 (dd, 1 H), 3.52 (td, 1 H), 2.68-2.98 (m, 2 H), 2.41 (s, 3 H) 400.2 [M+H] + 100%
1755 (CD 3OD) δ 8.65 (s, 2 H), 8.26 (d, 1 H), 7.64 (s, 1 H), 7.24 (s, 1 H), 6.95 (d, 1 H), 6.74 (t, 1 H), 6.54 (s, 1 H), 5.15 (dd, 1 H), 3.52 (td, 1 H), 2.67-3.00 (m, 2 H), 2.41 (s, 3 H) 400.2 [M+H] + 99.5%
1756 以上所提供之數據
1757 以上所提供之數據
1758 (CD 3OD) δ 8.30-8.40 (m, 1 H), 7.59 (s, 1 H), 7.29 (s, 0.3 H), 7.05-7.13 (m, 1 H), 6.76-6.85 (m, 1.7 H), 6.56-6.68 (m, 1 H), 4.89 (br dd, 1 H), 3.63 (ddd, 0.6 H), 3.28 (td, 0.4 H), 2.69-3.08 (m, 2 H), 1.32-1.42 (m, 9 H) 476.2 [M+H] + 99.8%
1759 (CD 3OD) δ 8.30-8.40 (m, 1 H), 7.59 (s, 1 H), 7.29 (s, 0.3 H), 7.05-7.12 (m, 1 H), 6.75-6.84 (m, 1.7 H), 6.57-6.69 (m, 1 H), 4.88 (br dd, 1 H), 3.58-3.67 (m, 0.6 H), 3.28 (td, 0.4 H), 2.70-3.08 (m, 2 H), 1.33-1.41 (m, 9 H) 476.1 [M+H] + 99.4%
1760 (CD 3OD) δ 8.78 (d, 1 H), 8.42-8.53 (m, 1 H), 8.32 (d, 1 H), 8.09 (t, 1 H), 7.65-7.76 (m, 2 H), 7.51 (s, 0.3 H), 7.17-7.25 (m, 1 H), 6.86-7.00 (m, 1.7 H), 6.75-6.82 (m, 1 H), 4.94-5.09 (m, 1 H), 3.77-3.85 (m, 0.6 H), 3.45 (td, 0.4 H), 2.84-3.24 (m, 2 H) 497.1 [M+H] + 100%
1761 (CD 3OD) δ 8.78 (d, 1 H), 8.42-8.56 (m, 1 H), 8.32 (d, 1 H), 8.09 (td, 1 H), 7.63-7.76 (m, 2 H), 7.51 (s, 0.3 H), 7.15-7.26 (m, 1 H), 6.86-7.01 (m, 1.7 H), 6.77-6.84 (m, 1 H), 4.94-5.09 (m, 1 H), 3.77-3.85 (m, 0.6 H), 3.40-3.49 (m, 0.4 H), 2.85-3.27 (m, 2 H) 497.1 [M+H] + 99.5%
1762 (CD 3OD) δ 8.56 (br d, 1 H), 8.41 (d, 2 H), 7.64 (s, 1 H), 7.40 (br d, 1 H), 7.21 (s, 1 H), 6.81-7.13 (m, 2 H), 6.71 (s, 1 H), 6.66 (t, 1 H), 5.06 (dd, 1 H), 3.40-3.51 (m, 1 H), 2.84-2.97 (m, 1 H), 2.70 (br dd, 1 H) 368.1 [M+H] + 100%
1763 (CD 3OD) δ 8.56 (d, 1 H), 8.41 (d, 2 H), 7.64 (s, 1 H), 7.40 (br d, 1 H), 7.21 (s, 1 H), 6.81-7.12 (m, 2 H), 6.71 (s, 1 H), 6.66 (t, 1 H), 5.06 (dd, 1 H), 3.40-3.52 (m, 1 H), 2.84-2.99 (m, 1 H), 2.70 (dd, 1 H) 368.2 [M+H] + 98.2%
1764 (CD 3OD) δ 8.39 (d, 2 H), 7.82 (d, 1 H), 7.61 (s, 1 H), 7.09-7.34 (m, 3 H), 6.75 (s, 1 H), 6.64 (t, 1 H), 5.08 (dd, 1 H), 3.61 (td, 1 H), 2.83-2.97 (m, 1 H), 2.71 (dd, 1 H) 386.1 [M+H] + 99.3%
1765 (CD 3OD) δ 8.39 (d, 2 H), 7.82 (d, 1 H), 7.61 (s, 1 H), 7.08-7.38 (m, 3 H), 6.75 (s, 1 H), 6.64 (t, 1 H), 5.08 (br dd, 1 H), 3.54-3.68 (m, 1 H), 2.83-2.97 (m, 1 H), 2.71 (br dd, 1 H) 386.1 [M+H] + 98.4%
1766 (CD 3OD) δ 8.60 (d, 1 H), 7.70 (s, 1 H), 7.45 (br d, 1 H), 6.83-7.15 (m, 2 H), 6.76 (s, 1 H), 6.43 (s, 1 H), 4.36 (dd, 1 H), 3.73-3.84 (m, 1 H), 3.02-3.16 (m, 1 H), 2.85 (dd, 1 H) 426.1 [M+H] + 99.8%
1767 (CD 3OD) δ 8.60 (br d, 1 H), 7.70 (s, 1 H), 7.45 (br d, 1 H), 6.83-7.15 (m, 2 H), 6.76 (s, 1 H), 6.43 (br s, 1 H), 4.36 (dd, 1 H), 3.79 (td, 1 H), 3.02-3.15 (m, 1 H), 2.85 (br dd, 1 H) 426.1 [M+H] + 99.6%
1768 (CD 3OD) δ 8.22-8.77 (m, 3 H), 7.86 (d, 1 H), 7.66 (s, 1 H), 7.29 (d, 1 H), 7.20 (dd, 1 H), 6.54-7.03 (m, 3 H), 4.60 (br s, 1 H), 3.61 (q, 1 H), 3.00-3.17 (m, 1 H), 2.66-2.83 (m, 1 H), 1.97-2.06 (m, 1 H), 0.98-1.07 (m, 2 H), 0.73-0.81 (m, 2 H) 458.2 [M+H] + 98.1%
1769 (CD 3OD) δ 8.25-8.68 (m, 3 H), 7.86 (d, 1 H), 7.67 (s, 1 H), 7.29 (d, 1 H), 7.19 (br d, 1 H), 6.40-6.97 (m, 3 H), 4.61 (br s, 1 H), 3.44-3.80 (m, 1 H), 3.01-3.18 (m, 1 H), 2.77 (br d, 1 H), 1.95-2.05 (m, 1 H), 0.97-1.07 (m, 2 H), 0.71-0.80 (m, 2 H) 458.1 [M+H] + 97.8%
1770 (CD 3OD) δ 8.03-8.83 (m, 2 H), 7.80-7.95 (m, 2 H), 7.66 (s, 1 H), 7.33-7.49 (m, 2 H), 6.59-7.17 (m, 4 H), 4.64 (br s, 1 H), 3.40-3.81 (m, 1 H), 3.01-3.17 (m, 1 H), 2.95 (s, 6 H), 2.77 (br d, 1 H) 477.2 [M+H] + 99.4%
1771 (CD 3OD) δ 8.00-8.80 (m, 2 H), 7.77-7.97 (m, 2 H), 7.66 (s, 1 H), 7.31-7.47 (m, 2 H), 6.55-7.18 (m, 4 H), 4.64 (br s, 1 H), 3.43-3.92 (m, 1 H), 3.01-3.13 (m, 1 H), 2.95 (s, 6 H), 2.77 (br d, 1 H) 477.2 [M+H] + 99.4%
1772 (CD 3OD) δ 8.41 (br d, 2 H), 7.92 (d, 1 H), 7.85 (d, 1 H), 7.66 (s, 1 H), 7.38 (dd, 1 H), 6.97 (dd, 1 H), 6.55-6.91 (m, 3 H), 4.63 (br s, 1 H), 3.45-3.80 (m, 1 H), 3.02-3.16 (m, 1 H), 2.95 (s, 6 H), 2.77 (br dd, 1 H) 445.2 [M+H] + 100%
1773 (CD 3OD) δ 8.41 (br d, 2 H), 7.91 (d, 1 H), 7.84 (d, 1 H), 7.65 (s, 1 H), 7.37 (dd, 1 H), 6.96 (dd, 1 H), 6.56-6.89 (m, 3 H), 4.63 (br s, 1 H), 3.43-3.78 (m, 1 H), 3.02-3.13 (m, 1 H), 2.94 (s, 6 H), 2.76 (br dd, 1 H) 445.2 [M+H] + 99.8%
1774 (CD 3OD) δ 8.57-8.74 (m, 3 H), 7.55-7.71 (m, 2 H), 7.24 (s, 1 H), 6.95 (t, 1 H), 6.71 (s, 1 H), 5.20 (dd, 1 H), 3.45-3.63 (m, 1 H), 2.67-3.00 (m, 2 H) 454.1 [M+H] + 99.4%
1775 (CD 3OD) δ 8.56-8.75 (m, 3 H), 7.54-7.69 (m, 2 H), 7.24 (s, 1 H), 6.95 (t, 1 H), 6.71 (s, 1 H), 5.20 (dd, 1 H), 3.44-3.58 (m, 1 H), 2.69-2.98 (m, 2 H) 454.1 [M+H] + 98.1%
1776 (CD 3OD) δ 8.49-8.69 (m, 3 H), 7.65 (s, 1 H), 7.39 (br d, 1 H), 7.25 (s, 1 H), 7.09 (s, 0.2 H), 6.78-7.00 (m, 1.8 H), 6.72 (s, 1 H), 5.18 (dd, 1 H), 3.51 (td, 1 H), 2.69-2.96 (m, 2 H) 436.1 [M+H] + 100%
1777 (CD 3OD) δ 8.47-8.71 (m, 3 H), 7.65 (s, 1 H), 7.39 (br d, 1 H), 7.25 (s, 1 H), 7.09 (s, 0.2 H), 6.78-6.99 (m, 1.8 H), 6.72 (s, 1 H), 5.18 (dd, 1 H), 3.51 (td, 1 H), 2.68-2.98 (m, 2 H) 436.1 [M+H] + 100%
1778 (CD 3OD) δ 8.67 (s, 2 H), 8.32 (d, 1 H), 7.66 (s, 1 H), 7.24 (s, 1 H), 6.94 (dd, 1 H), 6.81 (td, 1 H), 6.70 (s, 1 H), 5.20 (dd, 1 H), 3.48-3.63 (m, 1 H), 2.69-3.03 (m, 2 H) 404.1 [M+H] + 99.5%
1779 (CD 3OD) δ 8.64 (s, 2 H), 8.28 (d, 1 H), 7.65 (s, 1 H), 7.22 (s, 1 H), 6.91 (dd, 1 H), 6.73-6.82 (m, 1 H), 6.67 (s, 1 H), 5.17 (dd, 1 H), 3.51 (td, 1 H), 2.67-2.98 (m, 2 H) 404.2 [M+H] + 99.3%
1780 (CD 3OD) δ 8.65 (s, 2 H), 8.40 (d, 1 H), 7.65 (s, 1 H), 7.17-7.34 (m, 2 H), 6.80 (t, 1 H), 6.66 (s, 1 H), 5.18 (dd, 1 H), 3.51 (td, 1 H), 2.72-2.97 (m, 2 H) 420.1 [M+H] + 99.0%
1781 (CD 3OD) δ 8.66 (s, 2 H), 8.40 (br d, 1 H), 7.65 (s, 1 H), 7.13-7.33 (m, 2 H), 6.81 (t, 1 H), 6.66 (s, 1 H), 5.19 (dd, 1 H), 3.42-3.59 (m, 1 H), 2.66-2.98 (m, 2 H) 420.1 [M+H] + 99.4%
1782 (CD 3OD) δ 8.91-8.95 (m, 1 H), 8.44-8.53 (m, 1 H), 8.34-8.39 (m, 1 H), 7.78-7.82 (m, 1.2 H), 7.51-7.67 (m, 1 H), 7.16-7.26 (m, 1 H), 6.88-6.99 (m, 1.8 H), 6.76-6.83 (m, 1 H), 5.12 (dd, 1 H), 3.75-3.83 (m, 0.6 H), 3.40-3.48 (m, 0.4 H), 2.84-3.22 (m, 2 H) 536.1 [M+H] + 100%
1783 (CD3OD) δ 8.89-8.96 (m, 1 H), 8.43-8.52 (m, 1 H), 8.36 (s, 1 H), 7.72-7.82 (m, 1.2 H), 7.51-7.67 (m, 1 H), 7.17-7.28 (m, 1 H), 6.87-7.00 (m, 1.8 H), 6.74-6.83 (m, 1 H), 4.97-5.16 (m, 1 H), 3.75-3.83 (m, 0.6 H), 3.43 (td, 0.4 H), 2.85-3.22 (m, 2 H) 536.2 [M+H] + 100%
1784 (CD 3OD) δ 8.38-8.98 (m, 3 H), 7.91 (d, 1 H), 7.63-7.72 (m, 2 H), 7.42 (dd, 1 H), 7.02 (br t, 1 H), 6.58-6.92 (m, 2 H), 4.89-4.96 (m, 1 H), 3.69 (t, 2 H), 3.35-3.51 (m, 4 H), 3.04-3.19 (m, 1 H), 2.95 (t, 2 H), 2.73-2.84 (m, 1 H) 510.2 [M+H] + 99.5%
1785 (CD 3OD) δ 8.28-8.95 (m, 3 H), 7.91 (d, 1 H), 7.63-7.73 (m, 2 H), 7.43 (dd, 1 H), 6.58-7.10 (m, 3 H), 4.90-5.03 (m, 1 H), 3.69 (t, 2 H), 3.37 (s, 4 H), 3.04-3.16 (m, 1 H), 2.95 (t, 2 H), 2.80 (br dd, 1 H) 510.2 [M+H] + 100%
1786 (CD 3OD) δ 8.05-8.86 (m, 2 H), 7.76 (d, 1 H), 7.54 (s, 1 H), 7.33 (d, 1 H), 7.18 (dd, 1 H), 7.11 (ddd, 1 H), 6.42-6.87 (m, 3 H), 4.49-4.58 (m, 1 H), 3.24 (br s, 1 H), 2.89-3.01 (m, 1 H), 2.65 (br dd, 1 H), 2.26 (s, 3 H) 416.2 [M+H] + 99.5%
1787 (CD 3OD) δ 8.22-8.92 (m, 2 H), 7.90 (d, 1 H), 7.66 (s, 1 H), 7.47 (dd, 1 H), 7.33 (dd, 1 H), 7.25 (ddd, 1 H), 6.55-6.96 (m, 3 H), 4.62 (br s, 1 H), 3.35-3.77 (m, 1 H), 3.03-3.12 (m, 1 H), 2.78 (dd, 1 H), 2.40 (s, 3 H) 416.2 [M+H] + 99.5%
1788 (CD 3OD) δ 8.42 (s, 2 H), 8.14 (br d, 1 H), 7.86 (d, 1 H), 7.64 (s, 1 H), 7.20 (dd, 1 H), 6.39-6.93 (m, 4 H), 4.60-4.70 (m, 1 H), 3.95 (s, 3 H), 3.37-3.74 (m, 1 H), 2.98-3.11 (m, 1 H), 2.75 (br dd, 1 H), 1.94-2.07 (m, 1 H), 0.94-1.08 (m, 2 H), 0.71-0.85 (m, 2 H) 454.2 [M+H] + 97.5%
1789 (CD 3OD) δ 8.42 (s, 2 H), 8.14 (br d, 1 H), 7.86 (d, 1 H), 7.64 (s, 1 H), 7.20 (d, 1 H), 6.37-7.01 (m, 4 H), 4.59-4.71 (m, 1 H), 3.95 (s, 3 H), 3.49 (br s, 1 H), 3.00-3.10 (m, 1 H), 2.70-2.81 (m, 1 H), 1.95-2.08 (m, 1 H), 0.94-1.08 (m, 2 H), 0.72-0.83 (m, 2 H) 454.2 [M+H] + 97.8%
1790 (CD 3OD) δ 8.42 (s, 2 H), 7.87 (d, 1 H), 7.64 (s, 1 H), 7.46 (d, 1 H), 7.14-7.30 (m, 2 H), 6.38-7.05 (m, 3 H), 4.59-4.71 (m, 1 H), 3.45-3.98 (m, 1 H), 2.96-3.15 (m, 1 H), 2.76 (br d, 1 H), 1.96-2.09 (m, 1 H), 0.95-1.07 (m, 2 H), 0.72-0.84 (m, 2 H) 442.2 [M+H] + 99.7%
1791 (CD 3OD) δ 8.42 (s, 2 H), 7.87 (d, 1 H), 7.65 (s, 1 H), 7.45 (d, 1 H), 7.13-7.31 (m, 2 H), 6.44-7.01 (m, 3 H), 4.60-4.70 (m, 1 H), 3.47-3.92 (m, 1 H), 2.96-3.11 (m, 1 H), 2.76 (br dd, 1 H), 1.91-2.08 (m, 1 H), 0.97-1.11 (m, 2 H), 0.68-0.84 (m, 2 H) 442.2 [M+H] + 99.7%
1792 (CD 3OD) δ 8.51 (br d, 2 H), 7.77-7.94 (m, 2 H), 7.67 (s, 1 H), 7.37 (dd, 1 H), 7.29 (d, 1 H), 6.36-6.96 (m, 3 H), 4.63 (br s, 1 H), 3.38-3.72 (m, 1 H), 3.00-3.14 (m, 1 H), 2.94 (s, 6 H), 2.71-2.82 (m, 1 H) 461.2 [M+H] + 100%
1793 (CD 3OD) δ 8.51 (br d, 2 H), 7.80-7.95 (m, 2 H), 7.66 (s, 1 H), 7.37 (dd, 1 H), 7.29 (d, 1 H), 6.49-6.98 (m, 3 H), 4.65 (br s, 1 H), 3.43-3.83 (m, 1 H), 3.01-3.15 (m, 1 H), 2.94 (s, 6 H), 2.77 (br dd, 1 H) 461.2 [M+H] + 99.4%
1794 (CD 3OD) δ 8.49-9.39 (m, 1 H), 7.80-7.94 (m, 2 H), 7.63 (s, 1 H), 7.47 (d, 1 H), 7.36 (dd, 1 H), 7.13 (dd, 1 H), 6.34-6.91 (m, 3 H), 4.62-4.71 (m, 1 H), 3.49 (br s, 1 H), 3.00-3.10 (m, 1 H), 2.94 (s, 6 H), 2.69-2.78 (m, 4 H) 441.2 [M+H] + 99.9%
1795 (CD 3OD) δ 8.23-9.44 (m, 1 H), 7.78-7.95 (m, 2 H), 7.64 (s, 1 H), 7.47 (d, 1 H), 7.37 (dd, 1 H), 7.13 (dd, 1 H), 6.33-6.97 (m, 3 H), 4.63-4.73 (m, 1 H), 3.39-3.86 (m, 1 H), 2.99-3.14 (m, 1 H), 2.95 (s, 6 H), 2.70-2.78 (m, 4 H) 441.3 [M+H] + 99.7%
1796 (CD 3OD) δ 8.24-8.53 (m, 3 H), 7.79 (d, 1 H), 7.56 (s, 1 H), 7.30 (dd, 1 H), 6.87 (dd, 1 H), 6.40-6.82 (m, 3 H), 4.82 (br s, 1 H), 3.57 (t, 2 H), 3.24 (s, 4 H), 2.91-3.04 (m, 1 H), 2.83 (t, 2 H), 2.67 (br dd, 1 H) 460.2 [M+H] + 100%
1797 (CD 3OD) δ 8.25-8.55 (m, 3 H), 7.80 (d, 1 H), 7.56 (s, 1 H), 7.30 (dd, 1 H), 6.87 (dd, 1 H), 6.49-6.80 (m, 3 H), 4.81 (br s, 1 H), 3.57 (t, 2 H), 3.22-3.33 (m, 4 H), 2.88-3.05 (m, 1 H), 2.83 (t, 2 H), 2.67 (br dd, 1 H) 460.2 [M+H] + 99.2%
1798 (CD 3OD) δ 8.17 (d, 1 H), 7.55 (s, 1 H), 6.86 (d, 1 H), 6.66 (t, 1 H), 6.42 (s, 1 H), 6.17 (s, 1 H), 4.10 (dd, 1 H), 3.60 (ddd, 1 H), 2.83-3.00 (m, 1 H), 2.69 (dd, 1 H), 2.31 (s, 3 H), 1.28 (s, 9 H) 378.2 [M+H] + 99.8%
1799 (CD 3OD) δ 8.17 (br d, 1 H), 7.55 (s, 1 H), 6.86 (br d, 1 H), 6.66 (t, 1 H), 6.42 (s, 1 H), 6.17 (s, 1 H), 4.10 (br dd, 1 H), 3.51-3.70 (m, 1 H), 2.84-2.99 (m, 1 H), 2.69 (br dd, 1 H), 2.31 (s, 3 H), 1.28 (s, 9 H) 378.2 [M+H] + 99.7%
1800 (CD 3OD) δ 8.63 (s, 2 H), 7.51-7.65 (m, 2 H), 7.24 (s, 1 H), 7.13 (dd, 1 H), 6.98 (dd, 1 H), 6.69 (s, 1 H), 5.19 (dd, 1 H), 3.62 (td, 1 H), 2.71-2.97 (m, 2 H) 420.1 [M+H] + 99.5%
1801 (CD 3OD) δ 8.64 (s, 2 H), 7.50-7.67 (m, 2 H), 7.24 (s, 1 H), 7.14 (dd, 1 H), 6.98 (dd, 1 H), 6.69 (s, 1 H), 5.19 (dd, 1 H), 3.55-3.71 (m, 1 H), 2.72-2.95 (m, 2 H) 420.1 [M+H] + 99.8%
1802 (CD 3OD) δ 8.63 (s, 2 H), 7.61 (s, 1 H), 7.42 (d, 1 H), 7.24 (s, 1 H), 7.07 (dd, 1 H), 6.66 (d, 1 H), 6.51 (s, 1 H), 5.17 (dd, 1 H), 3.63 (td, 1 H), 2.70-2.95 (m, 2 H), 2.64 (s, 3 H) 400.2 [M+H] + 99.6%
1803 (CD 3OD) δ 8.64 (s, 2 H), 7.61 (s, 1 H), 7.43 (d, 1 H), 7.24 (s, 1 H), 7.08 (dd, 1 H), 6.67 (d, 1 H), 6.51 (s, 1 H), 5.17 (dd, 1 H), 3.63 (td, 1 H), 2.71-2.94 (m, 2 H), 2.64 (s, 3 H) 400.2 [M+H] + 99.2%
1804 (CD 3OD) δ 8.46 (d, 1 H), 8.31 (d, 1 H), 8.16 (dd, 1 H), 7.80 (d, 1 H), 7.64 (s, 1 H), 6.98 (d, 1 H), 6.82 (br s, 1 H), 6.77 (t, 1 H), 6.53 (s, 1 H), 4.70 (br dd, 1 H), 3.57-3.72 (m, 1 H), 2.91-3.06 (m, 1 H), 2.76 (dd, 1 H), 2.43 (s, 3 H) 332.2 [M+H] + 100%
1805 (CD 3OD) δ 8.46 (d, 1 H), 8.31 (d, 1 H), 8.13-8.22 (m, 1 H), 7.80 (d, 1 H), 7.64 (s, 1 H), 6.98 (d, 1 H), 6.82 (s, 1 H), 6.77 (t, 1 H), 6.53 (s, 1 H), 4.70 (br dd, 1 H), 3.63 (ddd, 1 H), 2.88-3.06 (m, 1 H), 2.76 (dd, 1 H), 2.43 (s, 3 H) 332.2 [M+H] + 97.6%
1806 (CD 3OD) δ 8.46 (d, 1 H), 7.69 (s, 1 H), 7.60 (d, 1 H), 7.21 (ddd, 1 H), 6.88 (td, 1 H), 6.59 (s, 1 H), 6.40 (s, 1 H), 4.34 (dd, 1 H), 3.79 (ddd, 1 H), 3.02-3.14 (m, 1 H), 2.84 (dd, 1 H) 376.1 [M+H] + 99.6%
1807 (CD 3OD) δ 8.46 (d, 1 H), 7.69 (s, 1 H), 7.60 (d, 1 H), 7.15-7.27 (m, 1 H), 6.81-6.93 (m, 1 H), 6.59 (s, 1 H), 6.40 (s, 1 H), 4.34 (dd, 1 H), 3.79 (ddd, 1 H), 3.00-3.14 (m, 1 H), 2.84 (dd, 1 H) 376.1 [M+H] + 99.9%
1808 (CD 3OD) δ 8.31 (d, 1 H), 7.70 (s, 1 H), 7.00 (d, 1 H), 6.80 (t, 1 H), 6.59 (s, 1 H), 6.41 (s, 1 H), 4.34 (dd, 1 H), 3.79 (ddd, 1 H), 3.00-3.16 (m, 1 H), 2.85 (dd, 1 H), 2.45 (s, 3 H) 390.2 [M+H] + 100%
1809 (CD 3OD) δ 8.31 (d, 1 H), 7.70 (s, 1 H), 7.00 (d, 1 H), 6.80 (t, 1 H), 6.59 (s, 1 H), 6.41 (s, 1 H), 4.34 (dd, 1 H), 3.79 (ddd, 1 H), 3.00-3.16 (m, 1 H), 2.85 (dd, 1 H), 2.45 (s, 3 H) 390.1 [M+H] + 100%
1810 (CD 3OD) δ 8.63 (s, 2 H), 7.80 (d, 1 H), 7.62 (s, 1 H), 7.18-7.30 (m, 3 H), 6.77 (s, 1 H), 5.21 (dd, 1 H), 3.65 (td, 1 H), 2.83-2.96 (m, 1 H), 2.70-2.81 (m, 1 H) 454.2 [M+H] + 98.9%
1811 (CD 3OD) δ 8.53 (s, 2 H), 7.70 (d, 1 H), 7.52 (s, 1 H), 7.06-7.23 (m, 3 H), 6.67 (s, 1 H), 5.11 (dd, 1 H), 3.48-3.63 (m, 1 H), 2.57-2.89 (m, 2 H) 454.1 [M+H] + 99.7%
1812 (CD 3OD) δ 8.54 (s, 2 H), 7.47-7.66 (m, 2 H), 7.26-7.44 (m, 1 H), 7.02-7.16 (m, 3 H), 6.56 (s, 1 H), 5.10 (dd, 1 H), 3.52 (td, 1 H), 2.58-2.87 (m, 2 H) 436.1 [M+H] + 99.8%
1813 (CD 3OD) δ 8.53 (s, 2 H), 7.49-7.63 (m, 2 H), 7.26-7.44 (m, 1 H), 6.97-7.15 (m, 3 H), 6.56 (s, 1 H), 5.10 (dd, 1 H), 3.43-3.59 (m, 1 H), 2.59-2.86 (m, 2 H) 436.1 [M+H] + 99.8%
1814 (CD 3OD) δ 8.45 (d, 1 H), 8.13 (br d, 1 H), 7.49-7.71 (m, 3 H), 7.12-7.24 (m, 1 H), 7.05 (d, 1 H), 6.83 (t, 1 H), 6.77 (br s, 1 H), 6.66 (dd, 1 H), 6.50 (s, 1 H), 4.56 (br dd, 1 H), 3.51-3.63 (m, 1 H), 2.87-3.06 (m, 1 H), 2.68 (br d, 1 H) 317.2 [M+H] + 100%
1815 (CD 3OD) δ 8.45 (br d, 1 H), 8.13 (br d, 1 H), 7.47-7.69 (m, 3 H), 7.12-7.25 (m, 1 H), 7.05 (d, 1 H), 6.71-6.89 (m, 2 H), 6.66 (dd, 1 H), 6.50 (s, 1 H), 4.56 (br dd, 1 H), 3.51-3.64 (m, 1 H), 2.89-3.04 (m, 1 H), 2.68 (br d, 1 H) 317.2 [M+H] + 100%
1816 (CD 3OD) δ 8.58 (br d, 1 H), 8.47 (d, 1 H), 8.16 (dd, 1 H), 7.80 (d, 1 H), 7.67 (br s, 1 H), 7.42 (br d, 1 H), 6.79-7.15 (m, 3 H), 6.70 (s, 1 H), 4.71 (dd, 1 H), 3.61 (ddd, 1 H), 2.91-3.04 (m, 1 H), 2.77 (br d, 1 H) 368.1 [M+H] + 100%
1817 (CD 3OD) δ 8.59 (d, 1 H), 8.47 (d, 1 H), 8.17 (dd, 1 H), 7.80-7.86 (m, 2 H), 7.42 (br d, 1 H), 6.79-7.16 (m, 3 H), 6.71 (s, 1 H), 4.71 (dd, 1 H), 3.61 (ddd, 1 H), 2.93-3.05 (m, 1 H), 2.78 (br dd, 1 H) 368.1 [M+H] + 98.2%
1818 (CD 3OD) δ 8.69 (d, 1 H), 8.47 (d, 1 H), 8.17 (dd, 1 H), 7.81 (d, 1 H), 7.57-7.72 (m, 2 H), 6.97 (t, 1 H), 6.86 (br s, 1 H), 6.69 (s, 1 H), 4.72 (br dd, 1 H), 3.61 (ddd, 1 H), 2.92-3.06 (m, 1 H), 2.77 (br dd, 1 H) 386.2 [M+H] + 100%
1819 (CD 3OD) δ 8.69 (d, 1 H), 8.47 (d, 1 H), 8.17 (dd, 1 H), 7.81 (d, 1 H), 7.57-7.72 (m, 2 H), 6.97 (t, 1 H), 6.86 (br s, 1 H), 6.69 (s, 1 H), 4.72 (br dd, 1 H), 3.61 (ddd, 1 H), 2.92-3.05 (m, 1 H), 2.77 (br dd, 1 H) 386.2 [M+H] + 99.6%
1820 (CD 3OD) δ 8.71 (d, 1 H), 7.71 (s, 1 H), 7.64 (d, 1 H), 7.01 (t, 1 H), 6.77 (s, 1 H), 6.43 (s, 1 H), 4.38 (dd, 1 H), 3.80 (td, 1 H), 3.03-3.15 (m, 1 H), 2.86 (dd, 1 H) 444.1 [M+H] + 95.6%
1821 (CD 3OD) δ 8.71 (d, 1 H), 7.70 (s, 1 H), 7.64 (d, 1 H), 7.00 (t, 1 H), 6.77 (s, 1 H), 6.43 (br s, 1 H), 4.38 (dd, 1 H), 3.72-3.86 (m, 1 H), 3.02-3.16 (m, 1 H), 2.86 (br dd, 1 H) 444.1 [M+H] + 93.2%
1822 (CD 3OD) δ 8.24 (d, 1 H), 7.58 (s, 1 H), 6.86 (dd, 1 H), 6.73 (td, 1 H), 6.61 (s, 1 H), 6.29 (s, 1 H), 4.24 (dd, 1 H), 3.68 (ddd, 1 H), 2.91-3.03 (m, 1 H), 2.73 (dd, 1 H) 394.1 [M+H] + 99.7%
1823 (CD 3OD) δ 8.23 (d, 1 H), 7.58 (s, 1 H), 6.86 (dd, 1 H), 6.73 (td, 1 H), 6.61 (s, 1 H), 6.29 (s, 1 H), 4.24 (dd, 1 H), 3.68 (ddd, 1 H), 2.90-3.03 (m, 1 H), 2.73 (dd, 1 H) 394.1 [M+H] + 99.8%
1824 (CD 3OD) δ 8.57 (d, 1 H), 7.67 (s, 1 H), 7.43 (br d, 1 H), 6.67-7.18 (m, 3 H), 6.31 (s, 1 H), 4.24 (dd, 1 H), 3.72 (ddd, 1 H), 2.95-3.14 (m, 1 H), 2.83 (dd, 1 H), 1.41 (s, 9 H) 414.2 [M+H] + 98.4%
1825 (CD 3OD) δ 8.57 (d, 1 H), 7.67 (s, 1 H), 7.43 (br d, 1 H), 6.62-7.19 (m, 3 H), 6.31 (br s, 1 H), 4.24 (dd, 1 H), 3.72 (ddd, 1 H), 2.97-3.11 (m, 1 H), 2.83 (br dd, 1 H), 1.41 (s, 9 H) 414.2 [M+H] + 99.8%
1826 (CD 3OD) δ 8.27 (d, 1 H), 8.06 (s, 2 H), 7.61 (s, 1 H), 7.05 (s, 1 H), 6.95 (d, 1 H), 6.74 (t, 1 H), 6.49 (s, 1 H), 4.81 (br dd, 1 H), 3.43 (ddd, 1 H), 2.84-2.95 (m, 1 H), 2.59-2.68 (m, 1 H), 2.42 (s, 3 H) 347.2 [M+H] + 97.1%
1827 (CD 3OD) δ 8.16 (d, 1 H), 7.91-7.99 (m, 2 H), 7.50 (s, 1 H), 6.93 (s, 1 H), 6.80-6.86 (m, 1 H), 6.62 (t, 1 H), 6.37 (s, 1 H), 4.65-4.70 (m, 1 H), 3.27-3.36 (m, 1 H), 2.72-2.83 (m, 1 H), 2.52 (dd, 1 H), 2.30 (s, 3 H) 347.2 [M+H] + 93.3%
1828 (CD 3OD) δ 8.59 (d, 1 H), 8.40 (s, 1 H), 7.81 (s, 1 H), 7.69 (s, 1 H), 7.42 (d, 1 H), 6.81-7.14 (m, 2 H), 6.75 (d, 2 H), 4.72 (br dd, 1 H), 3.61 (ddd, 1 H), 2.91-3.05 (m, 1 H), 2.79 (dd, 1 H) 402.1 [M+H] + 100%
1829 (CD 3OD) δ 8.59 (d, 1 H), 8.41 (s, 1 H), 7.81 (s, 1 H), 7.69 (s, 1 H), 7.43 (d, 1 H), 6.81-7.15 (m, 2 H), 6.75 (d, 2 H), 4.73 (dd, 1 H), 3.61 (ddd, 1 H), 2.92-3.04 (m, 1 H), 2.79 (dd, 1 H) 402.1 [M+H] + 99.9%
1830 (CD 3OD) δ 8.41 (d, 1 H), 7.66 (s, 1 H), 7.26 (d, 1 H), 6.82 (t, 1 H), 6.65 (s, 1 H), 6.30 (s, 1 H), 4.23 (dd, 1 H), 3.60-3.76 (m, 2 H), 2.95-3.09 (m, 1 H), 2.79 (br dd, 1 H), 2.33-2.48 (m, 4 H), 1.95-2.17 (m, 2 H) 396.1 [M+H] + 99.7%
1831 (CD 3OD) δ 8.36-8.51 (m, 1 H), 7.68 (s, 1 H), 7.28 (d, 1 H), 6.84 (t, 1 H), 6.67 (s, 1 H), 6.31 (s, 1 H), 4.25 (dd, 1 H), 3.60-3.76 (m, 2 H), 2.98-3.09 (m, 1 H), 2.77-2.86 (m, 1 H), 2.33-2.49 (m, 4 H), 1.97-2.20 (m, 2 H) 396.1 [M+H] + 98.9%
1832 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.86 (t, 1 H), 6.67 (s, 1 H), 6.30 (br s, 1 H), 4.24 (dd, 1 H), 3.71 (ddd, 1 H), 2.97-3.11 (m, 1 H), 2.82 (br dd, 1 H), 1.41 (s, 9 H) 398.2 [M+H] + 100%
1833 (CD 3OD) δ 8.44 (d, 1 H), 7.68 (s, 1 H), 7.30 (d, 1 H), 6.85 (t, 1 H), 6.67 (s, 1 H), 6.30 (br s, 1 H), 4.24 (dd, 1 H), 3.71 (ddd, 1 H), 2.96-3.10 (m, 1 H), 2.76-2.90 (m, 1 H), 1.41 (s, 9 H) 398.2 [M+H] + 100%
1834 (CD 3OD) δ 8.66 (d, 1 H), 8.06 (s, 2 H), 7.63 (s, 1 H), 7.59 (d, 1 H), 7.05 (s, 1 H), 6.94 (t, 1 H), 6.66 (s, 1 H), 4.84 (br d, 1 H), 3.42 (ddd, 1 H), 2.86-2.96 (m, 1 H), 2.61-2.69 (m, 1 H) 401.1 [M+H] + 89.0%
1835 (CD 3OD) δ 8.54 (d, 1 H), 7.94 (s, 2 H), 7.52 (s, 1 H), 7.43-7.50 (m, 1 H), 6.94 (s, 1 H), 6.82 (t, 1 H), 6.54 (s, 1 H), 4.72 (br d, 1 H), 3.30 (ddd, 1 H), 2.73-2.84 (m, 1 H), 2.53 (dd, 1 H) 401.2 [M+H] + 97.7%
1836 (CD 3OD) δ 8.31 (d, 1 H), 8.06 (s, 2 H), 7.62 (s, 1 H), 7.03 (s, 1 H), 6.92 (dd, 1 H), 6.78 (td, 1 H), 6.62 (s, 1 H), 4.78-4.84 (m, 1 H), 3.42 (ddd, 1 H), 2.83-2.97 (m, 1 H), 2.65 (dd, 1 H) 351.1 [M+H] + 98.8%
1837 (CD 3OD) δ 8.19 (d, 1 H), 7.94 (s, 2 H), 7.50 (s, 1 H), 6.91 (s, 1 H), 6.80 (dd, 1 H), 6.67 (td, 1 H), 6.50 (s, 1 H), 4.70 (br d, 1 H), 3.30 (ddd, 1 H), 2.70-2.88 (m, 1 H), 2.53 (dd, 1 H) 351.2 [M+H] + 90.6%
1838 (CD 3OD) δ 8.18-8.32 (m, 1 H), 7.68 (s, 1 H), 7.45 (br s, 0.3 H), 6.93 (s, 0.7 H), 6.58-6.84 (m, 3 H), 4.97 (br dd, 1 H), 3.65-3.78 (m, 0.7 H), 3.34-3.42 (m, 0.3 H), 3.06-3.18 (m, 0.7 H), 2.91-3.03 (m, 0.3 H), 2.81 (br dd, 1 H), 2.26-2.36 (m, 1 H), 2.01-2.14 (m, 1 H), 1.19-1.30 (m, 4 H), 0.97-1.08 (m, 2 H), 0.72-0.83 (m, 2 H) 416.2 [M+H] + 96.5%
1839 (CD 3OD) δ 8.20-8.35 (m, 1 H), 7.68 (s, 1 H), 7.45 (br s, 0.3 H), 6.93 (s, 0.7 H), 6.65-6.84 (m, 3 H), 4.97 (br dd, 1 H), 3.66-3.77 (m, 0.6 H), 3.33-3.44 (m, 0.4 H), 3.06-3.18 (m, 0.6 H), 2.91-3.03 (m, 0.4 H), 2.76-2.87 (m, 1 H), 2.24-2.44 (m, 1 H), 2.09 (td, 1 H), 1.20-1.30 (m, 4 H), 0.94-1.09 (m, 2 H), 0.69-0.86 (m, 2 H) 416.2 [M+H] + 91.5%
1840 (CD 3OD) δ 8.19-8.32 (m, 1 H), 7.69 (s, 1 H), 6.93-7.48 (m, 1 H), 6.66-6.85 (m, 3 H), 4.93-5.00 (m, 1 H), 3.75 (ddd, 0.7 H), 3.40 (td, 0.3 H), 3.09-3.21 (m, 0.7 H), 2.92-3.02 (m, 0.3 H), 2.83 (br dd, 1 H), 2.00-2.17 (m, 1 H), 1.42-1.53 (m, 9 H), 0.96-1.07 (m, 2 H), 0.71-0.82 (m, 2 H) 432.2 [M+H] + 100%
1841 (CD 3OD) δ 8.18-8.33 (m, 1 H), 7.69 (s, 1 H), 7.41 (br s, 0.3 H), 6.95 (s, 0.7 H), 6.63-6.84 (m, 3 H), 4.96 (dd, 1 H), 3.75 (ddd, 0.7 H), 3.35-3.45 (m, 0.3 H), 3.09-3.20 (m, 0.7 H), 2.92-3.03 (m, 0.3 H), 2.83 (br dd, 1 H), 2.01-2.15 (m, 1 H), 1.43-1.53 (m, 9 H), 0.98-1.07 (m, 2 H), 0.73-0.81 (m, 2 H) 432.2 [M+H] + 95.1%
1842 以上所提供之數據
1843 以上所提供之數據
1844 (CD 3OD) δ 8.31 (d, 1 H), 7.52-7.79 (m, 2 H), 7.23 (t, 2 H), 7.00 (d, 1 H), 6.79 (t, 1 H), 6.62 (s, 1 H), 6.42 (s, 1 H), 4.36 (dd, 1 H), 3.81 (ddd, 1 H), 3.02-3.17 (m, 1 H), 2.86 (br dd, 1 H), 2.45 (s, 3 H) 434.1 [M+H] + 99.7%
1845 (CD 3OD) δ 8.31 (d, 1 H), 7.54-7.78 (m, 2 H), 7.22 (t, 2 H), 6.99 (d, 1 H), 6.79 (t, 1 H), 6.61 (s, 1 H), 6.42 (s, 1 H), 4.36 (dd, 1 H), 3.80 (ddd, 1 H), 3.00-3.18 (m, 1 H), 2.85 (dd, 1 H), 2.45 (s, 3 H) 434.2 [M+H] + 99.7%
1846 (CD 3OD) δ 8.70 (br d, 1 H), 7.48-7.85 (m, 3 H), 7.22 (t, 2 H), 6.99 (t, 1 H), 6.79 (s, 1 H), 6.43 (br s, 1 H), 4.40 (dd, 1 H), 3.65-3.95 (m, 1 H), 2.99-3.19 (m, 1 H), 2.87 (br dd, 1 H) 488.1 [M+H] + 97.8%
1847 (CD 3OD) δ 8.70 (d, 1 H), 7.47-7.87 (m, 3 H), 7.22 (t, 2 H), 6.99 (t, 1 H), 6.79 (s, 1 H), 6.44 (s, 1 H), 4.40 (dd, 1 H), 3.67-3.99 (m, 1 H), 3.00-3.20 (m, 1 H), 2.87 (br dd, 1 H) 488.1 [M+H] + 99.4%
1848 (CD 3OD) δ 8.46 (br d, 1 H), 7.77 (br s, 1 H), 7.32 (d, 1 H), 6.87 (t, 1 H), 6.72 (s, 1 H), 6.42 (s, 1 H), 4.36 (dd, 1 H), 3.69-3.86 (m, 1 H), 3.01-3.16 (m, 1 H), 2.86 (br d, 1 H) 410.1 [M+H] + 99.8%
1849 (CD 3OD) δ 8.34 (d, 1 H), 7.65 (s, 1 H), 7.20 (d, 1 H), 6.75 (t, 1 H), 6.60 (s, 1 H), 6.31 (s, 1 H), 4.24 (dd, 1 H), 3.67 (ddd, 1 H), 2.90-3.02 (m, 1 H), 2.74 (dd, 1 H) 410.1 [M+H] + 99.6%
1850 (CD 3OD) δ 7.60 (s, 1 H), 7.36 (d, 1 H), 7.02 (dd, 1 H), 6.62 (d, 1 H), 6.41 (s, 1 H), 6.29 (s, 1 H), 4.23 (dd, 1 H), 3.69 (ddd, 1 H), 2.90-3.02 (m, 1 H), 2.74 (dd, 1 H), 2.52 (s, 3 H) 390.1 [M+H] + 99.4%
1851 (CD 3OD) δ 7.73 (s, 1 H), 7.48 (d, 1 H), 7.13 (dd, 1 H), 6.73 (d, 1 H), 6.53 (s, 1 H), 6.41 (s, 1 H), 4.35 (dd, 1 H), 3.80 (ddd, 1 H), 3.02-3.14 (m, 1 H), 2.85 (dd, 1 H), 2.63 (s, 3 H) 390.1 [M+H] + 93.6%
1852 (CD 3OD) δ 8.43 (d, 1 H), 7.94 (s, 2 H), 7.51 (s, 1 H), 7.28 (br d, 1 H), 6.83-6.99 (m, 1.8 H), 6.77 (t, 1 H), 6.70 (s, 0.2 H), 6.55 (s, 1 H), 4.70 (br d, 1 H), 3.25-3.34 (m, 1 H), 2.72-2.84 (m, 1 H), 2.53 (dd, 1 H) 383.2 [M+H] + 100%
1853 (CD 3OD) δ 8.43 (d, 1 H), 7.94 (s, 2 H), 7.51 (s, 1 H), 7.27 (br d, 1 H), 6.92-6.99 (m, 1.2 H), 6.84 (s, 0.6 H), 6.77 (t, 1 H), 6.70 (s, 0.2 H), 6.55 (s, 1 H), 4.70 (br d, 1 H), 3.26-3.34 (m, 1 H), 2.73-2.83 (m, 1 H), 2.52 (dd, 1 H) 383.2 [M+H] + 99.3%
1854 (CD 3OD) δ 8.63 (br d, 1 H), 8.17-8.32 (m, 1 H), 7.92 (br t, 1 H), 7.68-7.80 (m, 2 H), 7.47 (br s, 0.3 H), 6.99 (s, 0.7 H), 6.71-6.82 (m, 3 H), 4.93-4.99 (m, 1 H), 3.77-3.87 (m, 0.7 H), 3.45 (td, 0.3 H), 3.17-3.26 (m, 0.7 H), 2.98-3.07 (m, 0.3 H), 2.85 (br d, 1 H), 2.02-2.15 (m, 1 H), 0.95-1.07 (m, 2 H), 0.70-0.81 (m, 2 H) 471.2 [M+H] + 98.6%
1855 (CD 3OD) δ 8.62 (d, 1 H), 8.19-8.31 (m, 1 H), 7.91 (t, 1 H), 7.69-7.77 (m, 2 H), 7.47 (s, 0.3 H), 6.99 (s, 0.7 H), 6.71-6.82 (m, 3 H), 4.93-4.99 (m, 1 H), 3.77-3.86 (m, 0.7 H), 3.45 (td, 0.3 H), 3.17-3.26 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.86 (br dd, 1 H), 2.01-2.14 (m, 1 H), 0.96-1.07 (m, 2 H), 0.72-0.81 (m, 2 H) 471.2 [M+H] + 97.9%
1856 (CD 3OD) δ 9.44 (s, 1 H), 8.79-8.86 (m, 2 H), 8.19-8.30 (m, 1 H), 7.70 (s, 1 H), 7.50 (br s, 0.3 H), 6.98 (s, 0.7 H), 6.67-6.85 (m, 3 H), 5.01- 4.89 (br dd, 1 H), 3.77-3.86 (m, 0.6 H), 3.45 (td, 0.4 H), 3.14-3.27 (m, 0.7 H), 2.97-3.07 (m, 0.3 H), 2.80-2.91 (m, 1 H), 2.00-2.15 (m, 1 H), 0.96-1.08 (m, 2 H), 0.71-0.82 (m, 2 H) 454.2 [M+H] + 99.9%
1857 (CD 3OD) δ 9.45 (s, 1 H), 8.83 (br d, 2 H), 8.17-8.34 (m, 1 H), 7.70 (s, 1 H), 7.50 (s, 0.3 H), 6.99 (s, 0.7 H), 6.72-6.82 (m, 3 H), 4.93-5.05 (m, 1 H), 3.78-3.86 (m, 0.7 H), 3.45 (td, 0.3 H), 3.15-3.26 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.86 (br dd, 1 H), 1.99-2.15 (m, 1 H), 0.97-1.08 (m, 2 H), 0.72-0.82 (m, 2 H) 454.2 [M+H] + 99.3%
1858 (CD 3OD) δ 8.13-8.23 (m, 1 H), 7.58 (s, 1 H), 7.35 (s, 0.3 H), 6.91-6.97 (m, 1 H), 6.82 (s, 0.7 H), 6.65-6.76 (m, 1 H), 6.49-6.61 (m, 1 H), 4.82-4.87 (m, 1 H), 3.60-3.69 (m, 0.6 H), 3.24-3.34 (m, 0.4 H), 2.83-3.13 (m, 2 H), 2.71 (br dd, 1 H), 2.48-2.55 (m, 3 H), 1.18-1.26 (m, 6 H) 392.2 [M+H] + 100%
1859 (CD 3OD) δ 8.14-8.23 (m, 1 H), 7.58 (s, 1 H), 7.35 (s, 0.3 H), 6.91-6.98 (m, 1 H), 6.82 (s, 0.7 H), 6.68-6.76 (m, 1 H), 6.48-6.61 (m, 1 H), 4.81-4.88 (m, 1 H), 3.60-3.70 (m, 0.6 H), 3.24-3.34 (m, 0.4 H), 2.81-3.14 (m, 2 H), 2.65-2.77 (m, 1 H), 2.48-2.58 (m, 3 H), 1.18-1.26 (m, 6 H) 392.2 [M+H] + 99.7%
1860 (CD 3OD) δ 8.46 (d, 1 H), 8.03 (dd, 2 H), 7.69 (s, 1 H), 7.60 (d, 1 H), 7.30 (t, 2 H), 7.16-7.24 (m, 1 H), 6.86 (t, 1 H), 6.60 (s, 1 H), 6.45 (s, 1 H), 4.37 (dd, 1 H), 3.73-3.83 (m, 1 H), 3.02-3.21 (m, 1 H), 2.85 (dd, 1 H) 402.2 [M+H] + 100%
1861 (CD 3OD) δ 8.46 (br d, 1 H), 7.97-8.09 (m, 2 H), 7.67-7.73 (m, 1 H), 7.60 (br d, 1 H), 7.27-7.34 (m, 2 H), 7.16-7.24 (m, 1 H), 6.83-6.92 (m, 1 H), 6.60 (s, 1 H), 6.45 (s, 1 H), 4.32-4.45 (m, 1 H), 3.73-3.86 (m, 1 H), 3.04-3.18 (m, 1 H), 2.78-2.92 (m, 1 H) 402.2 [M+H] + 95.2%
1862 (CD 3OD) δ 8.58 (br d, 1 H), 7.50-7.82 (m, 2 H), 7.42 (br d, 1 H), 7.20 (t, 2 H), 6.83-7.14 (m, 2 H), 6.79 (s, 1 H), 6.44 (br s, 1 H), 4.38 (br dd, 1 H), 3.70-3.90 (m, 1 H), 3.01-3.17 (m, 1 H), 2.86 (br d, 1 H) 470.1 [M+H] + 99.7%
1863 (CD 3OD) δ 8.59 (d, 1 H), 7.55-7.79 (m, 2 H), 7.44 (br d, 1 H), 7.22 (t, 2 H), 6.84-7.15 (m, 2 H), 6.79 (s, 1 H), 6.44 (s, 1 H), 4.38 (dd, 1 H), 3.80 (ddd, 1 H), 3.01-3.20 (m, 1 H), 2.86 (dd, 1 H) 470.2 [M+H] + 99.5%
1864 (CD 3OD) δ 8.35 (d, 1 H), 7.52-7.80 (m, 2 H), 7.22 (t, 2 H), 6.97 (dd, 1 H), 6.84 (td, 1 H), 6.74 (s, 1 H), 6.42 (br s, 1 H), 4.38 (dd, 1 H), 3.81 (ddd, 1 H), 3.01-3.18 (m, 1 H), 2.86 (dd, 1 H) 438.1 [M+H] + 99.4%
1865 (CD 3OD) δ 8.23 (d, 1 H), 7.36-7.70 (m, 2 H), 7.10 (t, 2 H), 6.85 (dd, 1 H), 6.72 (td, 1 H), 6.62 (s, 1 H), 6.30 (br s, 1 H), 4.26 (dd, 1 H), 3.69 (ddd, 1 H), 2.88-3.06 (m, 1 H), 2.74 (br dd, 1 H) 438.2 [M+H] + 99.3%
1866 (CD 3OD) δ 8.35 (br s, 1 H), 7.30-7.91 (m, 3 H), 6.94-7.19 (m, 1 H), 6.27-6.87 (m, 3 H), 4.56-4.75 (m, 1 H), 4.26-4.43 (m, 0.5 H), 3.64 (br s, 0.5 H), 2.53-3.10 (m, 2 H), 1.31 (br s, 9 H) 391.2 [M+H] + 100%
1867 (CD 3OD) δ 8.31 (br s, 1 H), 7.33-7.96 (m, 3 H), 7.04 (br t, 1 H), 6.21-6.89 (m, 3 H), 4.70-4.81 (m, 1 H), 4.14-4.47 (m, 0.5 H), 3.63 (br s, 0.5 H), 2.47-3.08 (m, 2 H), 1.29 (br s, 9 H) 391.2 [M+H] + 99.5%
1868 (CD 3OD) δ 8.32-8.56 (m, 2 H), 8.11 (s, 1 H), 7.79 (br s, 1 H), 7.58 (s, 0.3 H), 7.41-7.51 (m, 1 H), 6.96 (s, 0.7 H), 6.60-6.86 (m, 2 H), 5.10 (br dd, 1 H), 4.00 (s, 3 H), 3.68-3.81 (m, 0.7 H), 3.37-3.45 (m, 0.3 H), 3.12-3.23 (m, 0.7 H), 2.94-3.05 (m, 0.3 H), 2.85 (br d, 1 H) 494.1 [M+H] + 100%
1869 (CD 3OD) δ 8.29-8.57 (m, 2 H), 8.11 (s, 1 H), 7.83 (br d, 1 H), 7.59 (s, 0.3 H), 7.43-7.50 (m, 1 H), 6.97 (s, 0.7 H), 6.65-6.85 (m, 2 H), 5.11 (br dd, 1 H), 4.01 (s, 3 H), 3.68-3.84 (m, 0.7 H), 3.41 (br d, 0.3 H), 2.95-3.24 (m, 1 H), 2.86 (br d, 1 H) 494.1 [M+H] + 99.4%
1870 (CD 3OD) δ 8.69 (d, 1 H), 8.14 (br d, 1 H), 7.71 (s, 1 H), 7.54-7.66 (m, 2 H), 7.06 (d, 1 H), 6.96 (t, 1 H), 6.86 (s, 1 H), 6.60-6.74 (m, 2 H), 4.57 (br dd, 1 H), 3.46-3.62 (m, 1 H), 2.90-3.03 (m, 1 H), 2.70 (br dd, 1 H) 385.1 [M+H] + 98.2%
1871 (CD 3OD) δ 8.69 (d, 1 H), 8.09-8.23 (m, 1 H), 7.77 (s, 1 H), 7.55-7.69 (m, 2 H), 7.06 (d, 1 H), 6.96 (t, 1 H), 6.89 (s, 1 H), 6.62-6.75 (m, 2 H), 4.57 (br dd, 1 H), 3.49-3.61 (m, 1 H), 2.91-3.05 (m, 1 H), 2.70 (br dd, 1 H) 385.2 [M+H] + 95.9%
1872 (CD 3OD) δ 8.41 (d, 1 H), 8.06 (s, 2 H), 7.63 (s, 1 H), 7.26 (d, 1 H), 7.03 (s, 1 H), 6.80 (t, 1 H), 6.61 (s, 1 H), 4.83 (br d, 1 H), 3.39-3.46 (m, 1 H), 2.84-2.95 (m, 1 H), 2.65 (br dd, 1 H) 367.1 [M+H] + 99.7%
1873 (CD 3OD) δ 8.41 (d, 1 H), 8.06 (s, 2 H), 7.62 (s, 1 H), 7.26 (d, 1 H), 7.03 (s, 1 H), 6.80 (t, 1 H), 6.61 (s, 1 H), 4.83 (br d, 1 H), 3.39-3.46 (m, 1 H), 2.85-2.95 (m, 1 H), 2.65 (dd, 1 H) 367.1 [M+H] + 98.5%
1874 (CD 3OD) δ 8.16-8.43 (m, 1 H), 7.68 (s, 1 H), 7.44 (s, 0.5 H), 6.76-7.09 (m, 2.5 H), 6.41-6.71 (m, 1 H), 4.97 (br dd, 1 H), 3.66-3.78 (m, 0.5 H), 3.38 (td, 0.5 H), 2.89-3.21 (m, 1 H), 2.71-2.88 (m, 3 H), 2.19-2.40 (m, 1 H), 1.13-1.34 (m, 7 H) 404.2 [M+H] + 100%
1875 (CD 3OD) δ 8.19-8.36 (m, 1 H), 7.68 (s, 1 H), 7.44 (br s, 0.5 H), 6.75-7.05 (m, 2.5 H), 6.50-6.68 (m, 1 H), 4.97 (br dd, 1 H), 3.65-3.84 (m, 0.5 H), 3.32-3.44 (m, 0.5 H), 2.90-3.22 (m, 1 H), 2.69-2.87 (m, 3 H), 2.18-2.39 (m, 1 H), 1.13-1.42 (m, 7 H) 404.2 [M+H] + 94.8%
1876 (CD 3OD) δ 8.39 (s, 1 H), 8.20-8.30 (m, 1 H), 8.07-8.12 (m, 1 H), 7.69 (s, 1 H), 7.57 (s, 0.3 H), 6.97 (s, 0.7 H), 6.70-6.83 (m, 3 H), 5.07 (br dd, 1 H), 4.00 (s, 3 H), 3.74-3.82 (m, 0.7 H), 3.42 (td, 0.3 H), 3.13-3.23 (m, 0.7 H), 2.95-3.03 (m, 0.3 H), 2.80-2.87 (m, 1 H), 2.01-2.15 (m, 1 H), 0.97-1.07 (m, 2 H), 0.73-0.81 (m, 2 H) 556.2 [M+H] + 100%
1877 (CD 3OD) δ 8.38 (s, 1 H), 8.20-8.29 (m, 1 H), 8.06-8.12 (m, 1 H), 7.69 (s, 1 H), 7.58 (s, 0.3 H), 6.96 (s, 0.7 H), 6.69-6.83 (m, 3 H), 5.07 (dd, 1 H), 4.00 (s, 3 H), 3.74-3.82 (m, 0.7 H), 3.42 (td, 0.3 H), 3.12-3.22 (m, 0.7 H), 2.93-3.04 (m, 0.3 H), 2.77-2.89 (m, 1 H), 2.01-2.15 (m, 1 H), 0.96-1.07 (m, 2 H), 0.72-0.81 (m, 2 H) 556.1 [M+H] + 95.1%
1878 (CD 3OD) δ 8.91 (s, 1 H), 8.34 (s, 1 H), 8.21-8.30 (m, 1 H), 7.92-8.00 (m, 1 H), 7.61-7.81 (m, 1 H), 7.50 (s, 0.2 H), 7.02 (s, 0.8 H), 6.74-6.84 (m, 3 H), 5.10 (br dd, 1 H), 3.74-3.83 (m, 0.7 H), 3.39-3.48 (m, 0.3 H), 3.17-3.24 (m, 0.7 H), 2.97-3.05 (m, 0.3 H), 2.83-2.92 (m, 1 H), 2.01-2.15 (m, 1 H), 0.98-1.06 (m, 2 H), 0.74-0.81 (m, 2 H) 492.2 [M+H] + 98.9%
1879 (CD 3OD) δ 8.92 (s, 1 H), 8.35 (s, 1 H), 8.21-8.30 (m, 1 H), 7.89-7.99 (m, 1 H), 7.61-7.82 (m, 1 H), 7.50 (s, 0.2 H), 7.02 (s, 0.8 H), 6.75-6.84 (m, 3 H), 5.10 (br dd, 1 H), 3.72-3.85 (m, 0.7 H), 3.39-3.47 (m, 0.3 H), 3.17-3.24 (m, 0.7 H), 3.00 (br dd, 0.3 H), 2.82-2.92 (m, 1 H), 2.03-2.15 (m, 1 H), 0.98-1.07 (m, 2 H), 0.74-0.81 (m, 2 H) 492.2 [M+H] + 98.2%
1880 (CD 3OD) δ 8.49 (d, 1 H), 8.19-8.33 (m, 1 H), 7.70 (s, 1 H), 7.52 (s, 0.3 H), 7.26 (d, 1 H), 6.98 (s, 0.7 H), 6.70-6.83 (m, 3 H), 4.92-5.05 (m, 1 H), 3.73-3.87 (m, 0.7 H), 3.43 (td, 0.3 H), 3.15-3.24 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.85 (br dd, 1 H), 2.01-2.15 (m, 1 H), 0.96-1.07 (m, 2 H), 0.71-0.82 (m, 2 H) 510.2 [M+H] + 100%
1881 (CD3OD) δ 8.49 (d, 1 H), 8.16-8.32 (m, 1 H), 7.70 (s, 1 H), 7.52 (s, 0.3 H), 7.26 (br s, 1 H), 6.98 (s, 0.7 H), 6.67-6.85 (m, 3 H), 4.92-5.06 (m, 1 H), 3.70-3.89 (m, 0.7 H), 3.43 (td, 0.3 H), 3.14-3.25 (m, 0.7 H), 2.96-3.06 (m, 0.3 H), 2.85 (br dd, 1 H), 2.00-2.15 (m, 1 H), 0.95-1.10 (m, 2 H) , 0.74 -0.79 (dt, 2 H) 510.2 [M+H] + 99.5%
1882 (CD 3OD) δ 8.08-8.25 (m, 1 H), 7.58 (s, 1 H), 7.34 (s, 0.3 H), 6.91-6.98 (m, 1 H), 6.69-6.83 (m, 1.7 H), 6.46-6.60 (m, 1 H), 4.87 (br dd, 1 H), 3.58-3.67 (m, 0.7 H), 3.26-3.34 (m, 0.3 H), 2.81-3.09 (m, 2 H), 2.71 (br dd, 1 H), 2.17-2.26 (m, 1 H), 1.08-1.26 (m, 10 H) 418.2 [M+H] + 100%
1883 (CD 3OD) δ 8.08-8.25 (m, 1 H), 7.58 (s, 1 H), 7.34 (s, 0.3 H), 6.91-6.98 (m, 1 H), 6.69-6.83 (m, 1.7 H), 6.46-6.60 (m, 1 H), 4.87 (br dd, 1 H), 3.58-3.67 (m, 0.6 H), 3.26-3.34 (m, 0.4 H), 2.81-3.09 (m, 2 H), 2.71 (br dd, 1 H), 2.17-2.26 (m, 1 H), 1.08-1.26 (m, 10 H) 418.2 [M+H] + 99.4%
1884 (CD 3OD) δ 8.07-8.23 (m, 1 H), 7.59 (s, 1 H), 7.29 (s, 0.3 H), 6.88-6.99 (m, 1 H), 6.84 (s, 0.7 H), 6.68-6.76 (m, 1 H), 6.48-6.62 (m, 1 H), 4.83-4.88 (m, 1 H), 3.66 (ddd, 0.6 H), 3.30 (td, 0.4 H), 2.83-3.12 (m, 2 H), 2.73 (br dd, 1 H), 1.73-1.84 (m, 6 H), 1.18-1.26 (m, 6 H) 438.2 [M+H] + 100%
1885 (CD 3OD) δ 8.12-8.23 (m, 1 H), 7.59 (s, 1 H), 7.29 (s, 0.3 H), 6.91-6.99 (m, 1 H), 6.84 (s, 0.7 H), 6.68-6.76 (m, 1 H), 6.46-6.63 (m, 1 H), 4.82-4.88 (m, 1 H), 3.62-3.71 (m, 0.6 H), 3.26-3.35 (m, 0.4 H), 2.83-3.13 (m, 2 H), 2.73 (br dd, 1 H), 1.73-1.86 (m, 6 H), 1.19-1.26 (m, 6 H) 438.2 [M+H] + 99.1%
1886 (CD 3OD) δ 8.37-8.44 (m, 1 H), 8.24-8.35 (m, 1 H), 8.06-8.16 (m, 1 H), 7.71 (s, 1 H), 7.57 (br s, 0.3 H), 7.02-7.11 (m, 1 H), 6.80-6.99 (m, 1.7 H), 6.62-6.74 (m, 1 H), 4.99-5.13 (m, 1 H), 4.02 (s, 3 H), 3.75-3.85 (m, 0.7 H), 3.38-3.50 (m, 0.3 H), 2.99-3.25 (m, 2 H), 2.81-2.92 (m, 1 H), 1.31-1.37 (m, 6 H) 458.2 [M+H] + 98.8%
1887 (CD 3OD) δ 8.40 (s, 1 H), 8.23-8.35 (m, 1 H), 8.07-8.13 (m, 1 H), 7.71 (s, 1 H), 7.57 (s, 0.3 H), 7.02-7.10 (m, 1 H), 6.81-6.99 (m, 1.7 H), 6.62-6.74 (m, 1 H), 5.01-5.13 (m, 1 H), 4.01 (s, 3 H), 3.75-3.86 (m, 0.7 H), 3.38-3.50 (m, 0.3 H), 2.97-3.24 (m, 2 H), 2.81-2.90 (m, 1 H), 1.29-1.37 (m, 6 H) 458.2 [M+H] + 95.4%
1888 (CD 3OD) δ 8.34-8.60 (m, 1 H), 7.62-7.91 (m, 2 H), 7.33-7.60 (m, 1.3 H), 6.89-7.17 (m, 1.7 H), 6.50-6.88 (m, 2 H), 5.03 (br dd, 1 H), 4.03 (s, 3 H), 3.71-3.81 (m, 0.6 H), 3.36-3.44 (m, 0.4 H), 3.12-3.24 (m, 0.5 H), 2.94-3.05 (m, 0.5 H), 2.84 (br d, 1 H) 494.1 [M+H] + 98.5%
1889 (CD 3OD) δ 8.34-8.56 (m, 1 H), 7.63-7.89 (m, 2 H), 7.26-7.61 (m, 1.3 H), 6.87-7.12 (m, 1.6 H), 6.59-6.84 (m, 2 H), 5.04 (br dd, 1 H), 4.03 (s, 3 H), 3.72-3.81 (m, 0.5 H), 3.34-3.44 (m, 0.5 H), 3.10-3.25 (m, 0.7 H), 2.93-3.07 (m, 0.3 H), 2.78-2.89 (m, 1 H) 494.1 [M+H] + 98.0%
1890 (CD 3OD) δ 8.32 (d, 1 H), 7.97-8.09 (m, 2 H), 7.69 (s, 1 H), 7.24-7.35 (m, 2 H), 6.99 (d, 1 H), 6.79 (t, 1 H), 6.59 (s, 1 H), 6.45 (s, 1 H), 4.37 (dd, 1 H), 3.79 (ddd, 1 H), 3.03-3.17 (m, 1 H), 2.85 (dd, 1 H), 2.45 (s, 3 H) 416.2 [M+H] + 99.4%
1891 (CD 3OD) δ 8.20 (d, 1 H), 7.85-8.00 (m, 2 H), 7.57 (s, 1 H), 7.12-7.25 (m, 2 H), 6.87 (d, 1 H), 6.67 (t, 1 H), 6.47 (s, 1 H), 6.33 (s, 1 H), 4.25 (dd, 1 H), 3.60-3.74 (m, 1 H), 2.90-3.04 (m, 1 H), 2.66-2.79 (m, 1 H), 2.33 (s, 3 H) 416.2 [M+H] + 98.3%
1892 (CD 3OD) δ 8.71 (d, 1 H), 7.97-8.09 (m, 2 H), 7.70 (s, 1 H), 7.63 (d, 1 H), 7.25-7.35 (m, 2 H), 6.99 (t, 1 H), 6.78 (s, 1 H), 6.48 (s, 1 H), 4.41 (dd, 1 H), 3.71-3.87 (m, 1 H), 3.03-3.19 (m, 1 H), 2.87 (dd, 1 H) 470.1 [M+H] + 99.9%
1893 (CD 3OD) δ 8.70 (d, 1 H), 7.98-8.08 (m, 2 H), 7.71 (s, 1 H), 7.63 (d, 1 H), 7.23-7.34 (m, 2 H), 6.99 (t, 1 H), 6.78 (s, 1 H), 6.48 (s, 1 H), 4.41 (dd, 1 H), 3.79 (ddd, 1 H), 3.05-3.18 (m, 1 H), 2.87 (dd, 1 H) 470.1 [M+H] + 98.5%
1894 (CD 3OD) δ 8.75 (d, 1 H), 8.17-8.35 (m, 2 H), 8.06 (td, 1 H), 7.58-7.75 (m, 2 H), 7.48 (s, 0.5 H), 6.92-7.05 (m, 1.5 H), 6.55-6.86 (m, 2 H), 4.99 (br dd, 1 H), 3.81 (ddd, 0.5 H), 3.44 (td, 0.5 H), 2.91-3.25 (m, 1 H), 2.72-2.88 (m, 3 H), 1.22-1.35 (m, 3 H) 441.2 [M+H] + 99.0%
1895 (CD 3OD) δ 8.76 (d, 1 H), 8.19-8.35 (m, 2 H), 8.06 (td, 1 H), 7.58-7.76 (m, 2 H), 7.48 (s, 0.5 H), 6.92-7.07 (m, 1.5 H), 6.73-6.85 (m, 1 H), 6.59-6.70 (m, 1 H), 5.00 (br dd, 1 H), 3.81 (ddd, 0.5 H), 3.44 (td, 0.5 H), 2.93-3.25 (m, 1 H), 2.71-2.89 (m, 3 H), 1.23-1.33 (m, 3 H) 441.2 [M+H] + 99.7%
1896 (CD 3OD) δ 8.77 (d, 1 H), 8.19-8.33 (m, 2 H), 8.08 (td, 1 H), 7.62-7.72 (m, 2 H), 7.50 (s, 0.3 H), 6.99 (s, 0.7 H), 6.71-6.84 (m, 3 H), 4.92-5.04 (m, 1 H), 3.82 (ddd, 0.7 H), 3.45 (td, 0.3 H), 3.16-3.25 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.86 (br dd, 1 H), 2.02-2.15 (m, 1 H), 0.97-1.08 (m, 2 H), 0.72-0.82 (m, 2 H) 453.2 [M+H] + 100%
1897 (CD 3OD) δ 8.76 (d, 1 H), 8.19-8.32 (m, 2 H), 8.07 (td, 1 H), 7.62-7.74 (m, 2 H), 7.50 (s, 0.3 H), 6.99 (s, 0.7 H), 6.71-6.82 (m, 3 H), 4.92-5.04 (m, 1 H), 3.77-3.86 (m, 0.7 H), 3.44 (td, 0.3 H), 3.16-3.25 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.81-2.90 (m, 1 H), 2.02-2.15 (m, 1 H), 0.97-1.07 (m, 2 H), 0.73-0.82 (m, 2 H) 453.2 [M+H] + 99.7%
1898 (CD 3OD) δ 8.19-8.38 (m, 1 H), 7.97-8.06 (m, 1 H), 7.71 (s, 1 H), 7.57 (s, 0.3), 6.99 (s, 0.7), 6.73-6.85 (m, 3 H), 5.07-5.12 (m, 1 H), 3.88-3.94 (m, 3 H), 3.76-3.85 (m, 0.7H), 3.46-3.51 (m, 0.3H), 3.14-3.26 (m, 1 H), 2.81-2.92 (m, 1 H), 2.62-2.76 (m, 3 H), 2.01-2.21 (m, 1 H), 0.99-1.10 (m, 2 H), 0.75-0.86 (m, 2 H) 470.2 [M+H] + 95.8%
1899 (CD 3OD) δ 8.08-8.24 (m, 1 H), 7.84-7.94 (m, 1 H), 7.60 (br s, 1 H), 7.45 (br s, 0.3 H), 6.87 (br s, 0.7 H), 6.57-6.76 (m, 3 H), 4.82-5.07 (m, 1 H), 3.75-3.84 (m, 3 H), 3.60-3.74 (m, 0.7 H), 3.27-3.40 (m, 0.3 H), 3.02-3.14 (m, 0.7 H), 2.83-2.97 (m, 0.3 H), 2.68-2.81 (m, 1 H), 2.50-2.62 (m, 3 H), 1.91-2.07 (m, 1 H), 0.85-1.01 (m, 2 H), 0.62-0.72 (m, 2 H) 470.2 [M+H] + 95.0%
1900 (CD 3OD) δ 8.21-8.33 (m, 1 H), 7.83 (d, 1 H), 7.72 (s, 1 H), 7.54 (s, 0.3 H), 6.95-7.05 (m, 1.7 H), 6.70-6.85 (m, 3 H), 4.99-5.08 (m, 1 H), 4.05 (s, 3 H), 3.75-3.87 (m, 0.7 H), 3.44 (td, 0.3 H), 3.14-3.26 (m, 0.7 H), 2.97-3.07 (m, 0.3 H), 2.81-2.91 (m, 1 H), 2.02-2.18 (m, 1 H), 0.98-1.11 (m, 2 H), 0.74-0.85 (m, 2 H) 456.2 [M+H] + 98.4%
1901 (CD 3OD) δ 8.21-8.35 (m, 1 H), 7.83 (d, 1 H), 7.72 (s, 1 H), 7.55 (br s, 0.3 H), 6.97-7.03 (m, 1.7 H), 6.71-6.86 (m, 3 H), 5.04-5.09 (m, 1 H), 4.05 (s, 3 H), 3.75-3.88 (m, 0.7 H), 3.45-3.51 (m, 0.3 H), 3.15-3.26 (m, 0.7 H), 2.97-3.07 (m, 0.3 H), 2.87 (br dd, 1 H), 2.02-2.19 (m, 1 H), 0.98-1.10 (m, 2 H), 0.71-0.86 (m, 2 H) 456.2 [M+H] + 99.4%
1902 (CD 3OD) δ 8.22-8.40 (m, 1 H), 7.71 (s, 1 H), 7.34-7.48 (m, 0.3 H), 7.03-7.11 (m, 1 H), 6.80-7.00 (m, 1.7 H), 6.59-6.75 (m, 1 H), 4.95-5.01 (m, 1 H), 3.70-3.82 (m, 0.6 H), 3.38-3.47 (m, 0.4 H), 2.92-3.25 (m, 2 H), 2.84 (br d, 1 H), 1.44-1.54 (m, 9 H), 1.30-1.40 (m, 6 H) 434.2 [M+H] + 100%
1903 (CD 3OD) δ 8.24-8.36 (m, 1 H), 7.71 (s, 1 H), 7.41 (s, 0.3 H), 7.04-7.11 (m, 1 H), 6.80-6.99 (m, 1.7 H), 6.58-6.74 (m, 1 H), 4.98 (br dd, 1 H), 3.72-3.82 (m, 0.6 H), 3.42 (td, 0.4 H), 2.97-3.26 (m, 2 H), 2.84 (br d, 1 H), 1.45-1.53 (m, 9 H), 1.31-1.38 (m, 6 H) 434.2 [M+H] + 99.4%
1904 (DMSO- d 6) δ 7.97 (br s, 1 H), 7.41-7.55 (m, 2 H), 7.24-7.33 (m, 1 H), 6.83-6.95 (m, 2 H), 6.67 (br s, 0.3 H), 6.14-6.32 (m, 1.7 H), 5.86-6.07 (m, 2 H), 4.15-4.25 (m, 1 H), 2.96-3.06 (m, 0.6 H), 2.60-2.72 (m, 0.4 H), 2.03-2.43 (m, 3 H), 0.49-0.57 (m, 6 H) 455.2 [M+H] + 99.7%
1905 (DMSO- d 6) δ 7.97 (br d, 1 H), 7.42-7.55 (m, 2 H), 7.28 (td, 1 H), 6.81-6.94 (m, 2 H), 6.68 (br s, 0.3 H), 6.16-6.29 (m, 1.7 H), 5.87-6.06 (m, 2 H), 4.22 (br s, 1 H), 2.99-3.08 (m, 0.6 H), 2.62-2.72 (m, 0.4 H), 2.03-2.42 (m, 3 H), 0.47-0.57 (m, 6 H) 455.2 [M+H] + 98.6%
1906 (CD 3OD) δ 8.65 (d, 1 H), 8.21-8.38 (m, 1 H), 7.94 (t, 1 H), 7.68-7.79 (m, 2 H), 7.45 (br s, 0.3 H), 6.97-7.10 (m, 1.7 H), 6.68-6.88 (m, 2 H), 4.93-5.02 (m, 1 H), 3.76-3.87 (m, 0.6 H), 3.43-3.52 (m, 0.4 H), 3.01-3.28 (m, 2 H), 2.87 (br d, 1 H), 1.31-1.38 (m, 6 H) 473.2 [M+H] + 100%
1907 (CD 3OD) δ 8.65 (d, 1 H), 8.23-8.36 (m, 1 H), 7.94 (t, 1 H), 7.68-7.79 (m, 2 H), 7.45 (br s, 0.3 H), 6.97-7.11 (m, 1.7 H), 6.68-6.89 (m, 2 H), 4.93-5.01 (m, 1 H), 3.79-3.89 (m, 0.6 H), 3.43-3.52 (m, 0.4 H), 3.00-3.27 (m, 2 H), 2.82-2.92 (m, 1 H), 1.31-1.37 (m, 6 H) 473.2 [M+H] + 99.7%
1908 (CD 3OD) δ 8.36-8.57 (m, 1 H), 7.69 (s, 1 H), 7.35-7.56 (m, 1.3 H), 6.90 (s, 0.7 H), 6.74-6.82 (m, 1 H), 6.59-6.71 (m, 1 H), 4.99 (br dd, 1 H), 3.66-3.76 (m, 0.6 H), 3.34-3.40 (m, 0.4 H), 3.07-3.18 (m, 0.7 H), 2.91-3.01 (m, 0.3 H), 2.76-2.86 (m, 1 H), 2.24-2.38 (m, 1 H), 1.19-1.31 (m, 4 H) 454.1 [M+H] + 99.3%
1909 (CD 3OD) δ 8.38-8.53 (m, 1 H), 7.69 (s, 1 H), 7.34-7.59 (m, 1.3 H), 6.90 (s, 0.7 H), 6.75-6.82 (m, 1 H), 6.60-6.72 (m, 1 H), 4.99 (br dd, 1 H), 3.67-3.75 (m, 0.6 H), 3.35-3.40 (m, 0.4 H), 3.08-3.17 (m, 0.7 H), 2.92-3.01 (m, 0.3 H), 2.81 (br d, 1 H), 2.26-2.39 (m, 1 H), 1.19-1.29 (m, 4 H) 454.1 [M+H] + 93.7%
1910 (CD 3OD) δ 8.78 (br d, 1 H), 8.40-8.52 (m, 1 H), 8.31 (d, 1 H), 8.08 (t, 1 H), 7.62-7.76 (m, 2 H), 7.39-7.55 (m, 1.4 H), 6.97 (s, 0.6 H), 6.67-6.84 (m, 2 H), 4.94-5.07 (m, 1 H), 3.74-3.83 (m, 0.7 H), 3.38-3.46 (m, 0.3 H), 3.16-3.25 (m, 0.7 H), 2.96-3.06 (m, 0.3 H), 2.81-2.89 (m, 1 H) 491.1 [M+H] + 99.9%
1911 (CD 3OD) δ 8.77 (dd, 1 H), 8.39-8.52 (m, 1 H), 8.25-8.35 (m, 1 H), 8.08 (td, 1 H), 7.60-7.74 (m, 2 H), 7.40-7.53 (m, 1.3 H), 6.97 (s, 0.7 H), 6.66-6.86 (m, 2 H), 5.02 (br dd, 1 H), 3.74-3.83 (m, 0.5 H), 3.42 (td, 0.5 H), 3.16-3.25 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.80-2.92 (m, 1 H) 491.1 [M+H] + 98.6%
1912 (CD 3OD) δ 8.47 (d, 1 H), 7.86-7.97 (m, 2 H), 7.58 (s, 1 H), 7.31 (br d, 1 H), 7.13-7.22 (m, 2 H), 7.00 (s, 0.2, 6.78-6.88 (m, 1.5, 6.73 (s, 0.3, 6.66 (s, 1 H), 6.35 (s, 1 H), 4.27 (dd, 1 H), 3.67 (ddd, 1 H), 2.91-3.07 (m, 1 H), 2.74 (dd, 1 H) 452.2 [M+H] + 99.3%
1913 (CD 3OD) δ 8.60 (br d, 1 H), 7.97-8.10 (m, 2 H), 7.70 (s, 1 H), 7.44 (br d, 1 H), 7.25-7.34 (m, 2 H), 7.12 (s, 0.2, 6.90-7.01 (m, 1.5, 6.85 (s, 0.3) 6.78 (s, 1 H), 6.47 (s, 1 H), 4.39 (br dd, 1 H), 3.74-3.83 (m, 1 H), 3.06-3.16 (m, 1 H), 2.86 (br dd, 1 H) 452.2 [M+H] + 98.8%
1914 (CD 3OD) δ 8.36-8.49 (m, 2 H), 7.76 (dd, 1 H), 7.64 (s, 1 H), 7.56 (d, 1 H), 7.10-7.24 (m, 2 H), 6.91 (s, 1 H), 6.83 (td, 1 H), 6.53 (s, 1 H), 4.71 (br dd, 1 H), 3.61 (ddd, 1 H), 2.89-3.02 (m, 1 H), 2.73 (dd, 1 H) 385.2 [M+H] + 100%
1915 (CD 3OD) δ 8.26-8.36 (m, 2 H), 7.64 (dd, 1 H), 7.52 (s, 1 H), 7.44 (d, 1 H), 6.97-7.10 (m, 2 H), 6.79 (s, 1 H), 6.71 (td, 1 H), 6.41 (s, 1 H), 4.59 (br dd, 1 H), 3.40-3.55 (m, 1 H), 2.75-2.91 (m, 1 H), 2.61 (dd, 1 H) 385.1 [M+H] + 99.2%
1916 (CD 3OD) δ 8.46 (br d, 1 H), 8.30 (s, 1 H), 7.65 (dd, 1 H), 7.53 (s, 1 H), 7.29 (br d, 1 H), 6.68-7.08 (m, 4 H), 6.58 (s, 1 H), 4.61 (br dd, 1 H), 3.42-3.54 (m, 1 H), 2.77-2.91 (m, 1 H), 2.62 (br dd, 1 H) 435.1 [M+H] + 100%
1917 (CD 3OD) δ 8.58 (br d, 1 H), 8.42 (s, 1 H), 7.72-7.85 (m, 1 H), 7.66 (s, 1 H), 7.42 (br d, 1 H), 6.79-7.22 (m, 4 H), 6.70 (s, 1 H), 4.73 (br dd, 1 H), 3.53-3.65 (m, 1 H), 2.91-3.04 (m, 1 H), 2.69-2.82 (m, 1 H) 435.1 [M+H] + 100%
1918 (CD 3OD) δ 8.18-8.44 (m, 1 H), 7.52-7.98 (m, 2 H), 6.98 (br d, 1 H), 6.43-6.89 (m, 3 H), 4.40-4.57 (m, 0.5 H), 3.57-3.84 (m, 0.5 H), 2.90-3.18 (m, 1 H), 2.61-2.88 (m, 1 H), 2.43 (s, 3 H), 2.08-2.31 (m, 1 H), 0.93-1.36 (m, 5 H) 389.2 [M+H] + 98.5%
1919 (CD 3OD) δ 8.24-8.44 (m, 1 H), 7.53-7.95 (m, 2 H), 7.00 (br d, 1 H), 6.41-6.93 (m, 3 H), 4.39-4.55 (m, 0.5 H), 3.64-3.85 (m, 0.5 H), 2.93-3.11 (m, 1 H), 2.82 (br d, 1 H), 2.45 (s, 3 H), 2.19 (br d, 1 H), 0.95-1.39 (m, 5 H) 389.2 [M+H] + 97.4%
1920 (CD 3OD) δ 8.19 (br s, 1 H), 7.35-7.98 (m, 2 H), 6.13-7.14 (m, 4 H), 4.42-4.67 (m, 1 H), 3.23-3.81 (m, 1 H), 2.57-3.08 (m, 2 H), 2.32 (s, 3 H), 1.32 (br s, 9 H) 405.2 [M+H] + 99.7%
1921 (CD 3OD) δ 8.31 (br d, 1 H), 7.39-8.06 (m, 2 H), 6.28-7.19 (m, 4 H), 4.53-4.70 (m, 1 H), 3.35-3.96 (m, 1 H), 2.65-3.17 (m, 2 H), 2.45 (br s, 3 H), 1.42 (br s, 9 H) 405.2 [M+H] + 99.6%
1922 (CD 3OD) δ 8.23-8.33 (m, 1 H), 7.69 (s, 1 H), 7.40 (s, 0.5 H), 6.88-7.04 (m, 1.5 H), 6.81 (q, 1 H), 6.52-6.69 (m, 1 H), 4.92-4.99 (m, 1 H), 3.76 (ddd, 0.5 H), 3.36-3.44 (m, 0.5 H), 2.77-3.21 (m, 4 H), 1.83-1.93 (m, 6 H), 1.27-1.35 (m, 3 H) 424.2 [M+H] + 99.1%
1923 (CD 3OD) δ 8.17-8.38 (m, 1 H), 7.69 (s, 1 H), 7.40 (s, 0.5 H), 6.89-7.09 (m, 1.5 H), 6.75-6.87 (m, 1 H), 6.50-6.69 (m, 1 H), 4.96 (br d, 1 H), 3.76 (ddd, 0.5 H), 3.39 (br dd, 0.5 H), 2.74-3.20 (m, 4 H), 1.77-1.98 (m, 6 H), 1.27-1.34 (m, 3 H) 424.2 [M+H] + 98.6%
1924 (CD 3OD) δ 8.21-8.42 (m, 2 H), 7.98-8.14 (m, 1 H), 7.48-7.76 (m, 1.5 H), 6.90-7.08 (m, 1.5 H), 6.76-6.86 (m, 1 H), 6.55-6.68 (m, 1 H), 5.06 (br dd, 1 H), 4.00 (s, 3 H), 3.72-3.83 (m, 0.5 H), 3.41 (td, 0.5 H), 2.75-3.22 (m, 4 H), 1.23-1.36 (m, 3 H) 444.2 [M+H] + 96.6%
1925 (CD 3OD) δ 8.21-8.44 (m, 2 H), 8.02-8.16 (m, 1 H), 7.69 (s, 1.5 H), 6.91-7.10 (m, 1.5 H), 6.73-6.87 (m, 1 H), 6.46-6.72 (m, 1 H), 5.07 (br dd, 1 H), 4.00 (s, 3 H), 3.71-3.83 (m, 0.5 H), 3.38-3.45 (m, 0.5 H), 2.79-3.21 (m, 4 H), 1.24-1.36 (m, 3 H) 444.2 [M+H] + 95.6%
1926 (500 MHz, CD 3OD) δ 8.18-8.35 (m, 1 H), 7.77-7.87 (m, 1 H), 7.71 (s, 1 H), 7.53 (s, 0.5 H), 6.94-7.07 (m, 2.5 H), 6.75-6.87 (m, 1 H), 6.56-6.73 (m, 1 H), 5.03 (br dd, 1 H), 4.03 (s, 3 H), 3.71-3.86 (m, 0.5 H), 3.43 (td, 0.5 H), 2.91-3.26 (m, 1 H), 2.72-2.88 (m, 3 H), 1.15-1.42 (m, 3 H) 444.2 [M+H] + 99.2%
1927 (CD 3OD) δ 8.02-8.26 (m, 1 H), 7.68 (d, 1 H), 7.59 (s, 1 H), 7.40 (s, 0.5 H), 6.77-6.98 (m, 2.5 H), 6.61-6.74 (m, 1 H), 6.46-6.57 (m, 1 H), 4.91 (br dd, 1 H), 3.90 (s, 3 H), 3.60-3.76 (m, 0.5 H), 3.31 (td, 0.5 H), 2.82-3.13 (m, 1 H), 2.60-2.78 (m, 3 H), 1.04-1.26 (m, 3 H) 444.2 [M+H] + 99.3%
1928 (CD 3OD) δ 9.08-9.19 (m, 1 H), 8.48 (s, 1 H), 8.21-8.33 (m, 1 H), 7.72 (s, 1 H), 7.50-7.62 (m, 0.3 H), 6.92-7.08 (m, 0.7 H), 6.72-6.85 (m, 3 H), 4.94-5.12 (m, 1 H), 3.77-3.88 (m, 0.7 H), 3.41-3.51 (m, 0.3 H), 3.14-3.24 (m, 0.7 H), 2.96-3.08 (m, 0.3 H), 2.80-2.92 (m, 1 H), 1.99-2.21 (m, 1 H), 0.96-1.12 (m, 2 H), 0.72-0.87 (m, 2 H) 510.2 [M+H] + 99.6%
1929 (CD 3OD) δ 9.09-9.16 (m, 1 H), 8.48 (s, 1 H), 8.22-8.32 (m, 1 H), 7.72 (s, 1 H), 7.58 (s, 0.3 H), 6.99 (s, 0.7 H), 6.72-6.86 (m, 3 H), 5.07 (dd, 1 H), 3.77-3.87 (m, 0.7 H), 3.41-3.49 (m, 0.3 H), 3.15-3.23 (m, 0.7 H), 2.97-3.06 (m, 0.3 H), 2.82-2.91 (m, 1 H), 2.03-2.17 (m, 1 H), 1.00-1.09 (m, 2 H), 0.75-0.84 (m, 2 H) 510.2 [M+H] + 99.1%
1930 (CD 3OD) δ 8.08-8.29 (m, 2 H), 7.72 (s, 0.3 H), 7.59 (d, 1.5 H), 7.42 (s, 0.5 H), 7.11 (d, 1 H), 6.88 (s, 0.7 H), 6.59-6.75 (m, 3 H), 4.92 (dd, 1 H), 3.63-3.77 (m, 0.7 H), 3.33 (td, 0.3 H), 3.03-3.14 (m, 0.7 H), 2.85-2.96 (m, 0.3 H), 2.75 (br dd, 1 H), 1.90-2.05 (m, 1 H), 0.85-0.98 (m, 2 H), 0.61-0.71 (m, 2 H) 492.2 [M+H] + 99.3%
1931 (CD 3OD) δ 8.09-8.25 (m, 2 H), 7.72 (s, 0.3 H), 7.55-7.62 (m, 1.5 H), 7.42 (s, 0.5 H), 7.11 (d, 1 H), 6.88 (s, 0.7 H), 6.60-6.73 (m, 3 H), 4.92 (dd, 1 H), 3.64-3.75 (m, 0.7 H), 3.29-3.38 (m, 0.3 H), 3.04-3.13 (m, 0.7 H), 2.85-2.96 (m, 0.3 H), 2.70-2.80 (m, 1 H), 1.88-2.08 (m, 1 H), 0.87-0.98 (m, 2 H), 0.63-0.72 (m, 2 H) 492.2 [M+H] + 99.1%
1932 (CD 3OD) δ 8.18-8.28 (m, 1 H), 7.69 (s, 1 H), 7.52 (s, 0.3 H), 6.96 (s, 0.7 H), 6.69-6.80 (m, 4 H), 5.00 (br dd, 1 H), 3.88 (s, 3 H), 3.74-3.82 (m, 0.7 H), 3.41 (td, 0.3 H), 3.12-3.23 (m, 0.7 H), 2.95-3.03 (m, 0.3 H), 2.79-2.87 (m, 1 H), 2.37 (s, 3 H), 2.00-2.13 (m, 1 H), 0.95-1.05 (m, 2 H), 0.70-0.80 (m, 2 H) 470.2 [M+H] + 99.8%
1933 (CD 3OD) δ 8.18-8.29 (m, 1 H), 7.69 (s, 1 H), 7.52 (s, 0.3 H), 6.97 (s, 0.7 H), 6.68-6.81 (m, 4 H), 5.00 (br dd, 1 H), 3.88 (s, 3 H), 3.75-3.83 (m, 0.7 H), 3.41 (td, 0.3 H), 3.11-3.23 (m, 0.7 H), 2.94-3.04 (m, 0.3 H), 2.78-2.88 (m, 1 H), 2.37 (s, 3 H), 1.99-2.14 (m, 1 H), 0.94-1.07 (m, 2 H), 0.68-0.83 (m, 2 H) 470.2 [M+H] + 99.6%
1934 (CD 3OD) δ 9.31-9.40 (m, 1 H), 8.73 (br d, 2 H), 8.12-8.22 (m, 1 H), 7.60 (s, 1 H), 7.36 (s, 0.3 H), 6.85-6.98 (m, 1.7 H), 6.58-6.76 (m, 2 H), 4.84-4.94 (m, 1 H), 3.65-3.79 (m, 0.7 H), 3.32-3.42 (m, 0.3 H), 2.87-3.13 (m, 2 H), 2.76 (br dd, 1 H), 1.19-1.25 (m, 6 H) 456.2 [M+H] + 100%
1935 (CD 3OD) δ 9.29-9.41 (m, 1 H), 8.71-8.77 (m, 2 H), 8.12-8.23 (m, 1 H), 7.60 (s, 1 H), 7.37 (s, 0.3 H), 6.86-6.98 (m, 1.7 H), 6.58-6.76 (m, 2 H), 4.91 (br dd, 1 H), 3.67-3.78 (m, 0.7 H), 3.31-3.42 (m, 0.3 H), 2.88-3.13 (m, 2 H), 2.70-2.81 (m, 1 H), 1.20-1.26 (m, 6 H) 456.2 [M+H] + 99.7%
1936 (CD 3OD) δ 8.77-8.84 (m, 1 H), 8.10-8.25 (m, 2 H), 7.39-7.69 (m, 2.5 H), 6.85-6.97 (m, 1.5 H), 6.51-6.75 (m, 2 H), 4.96 (br dd, 1 H), 3.65-3.76 (m, 0.7 H), 3.33 (td, 0.3 H), 2.86-3.13 (m, 2 H), 2.69-2.79 (m, 1 H), 1.18-1.25 (m, 6 H) 494.2 [M+H] + 100%
1937 (CD 3OD) δ 8.90-8.95 (m, 1 H), 8.24-8.38 (m, 2 H), 7.50-7.84 (m, 2.5 H), 6.97-7.09 (m, 1.5 H), 6.65-6.88 (m, 2 H), 5.08 (br dd, 1 H), 3.76-3.87 (m, 0.7 H), 3.45 (td, 0.3 H), 2.98-3.25 (m, 2 H), 2.82-2.92 (m, 1 H), 1.31-1.37 (m, 6 H) 494.2 [M+H] + 99.8%
1938 (CD 3OD) δ 8.31-8.54 (m, 1 H), 7.70 (s, 1 H), 7.29-7.50 (m, 1.4 H), 6.93 (br s, 0.6 H), 6.58-6.84 (m, 2 H), 4.97 (br dd, 1 H), 3.69-3.78 (m, 0.6 H), 3.35-3.41 (m, 0.4 H), 2.94-3.20 (m, 1 H), 2.78-2.88 (m, 1 H), 1.85-1.93 (m, 6 H) 474.1 [M+H] + 96.1%
1939 (CD 3OD) δ 8.31-8.62 (m, 1 H), 7.70 (s, 1 H), 7.29-7.56 (m, 1.3 H), 6.93 (br s, 0.7 H), 6.52-6.85 (m, 2 H), 4.97 (br dd, 1 H), 3.35-3.79 (m, 1 H), 2.93-3.20 (m, 1 H), 2.83 (br d, 1 H), 1.78-1.97 (m, 6 H) 474.1 [M+H] + 91.2%
1940 (CD 3OD) δ 8.42 (s, 1 H), 8.31 (d, 1 H), 7.77 (dd, 1 H), 7.64 (s, 1 H), 7.14 (d, 1 H), 6.86-7.01 (m, 2 H), 6.76 (t, 1 H), 6.53 (s, 1 H), 4.72 (br dd, 1 H), 3.55-3.68 (m, 1 H), 2.88-3.02 (m, 1 H), 2.74 (dd, 1 H), 2.43 (s, 3 H) 399.2 [M+H] + 99.9%
1941 (CD 3OD) δ 8.42 (s, 1 H), 8.31 (d, 1 H), 7.77 (dd, 1 H), 7.64 (s, 1 H), 7.14 (d, 1 H), 6.87-7.01 (m, 2 H), 6.76 (t, 1 H), 6.53 (s, 1 H), 4.72 (br dd, 1 H), 3.55-3.68 (m, 1 H), 2.89-3.03 (m, 1 H), 2.74 (dd, 1 H), 2.43 (s, 3 H) 399.2 [M+H] + 98.8%
1942 (CD 3OD) δ 8.41 (s, 1 H), 8.32 (d, 1 H), 7.76 (dd, 1 H), 7.70 (s, 1 H), 7.13 (d, 1 H), 6.88-6.99 (m, 2 H), 6.80 (td, 1 H), 6.65 (s, 1 H), 4.71 (br dd, 1 H), 3.59 (ddd, 1 H), 2.85-3.02 (m, 1 H), 2.73 (dd, 1 H) 403.1 [M+H] + 99.1%
1943 (CD 3OD) δ 8.40 (s, 1 H), 8.32 (d, 1 H), 7.76 (dd, 1 H), 7.63 (s, 1 H), 7.13 (d, 1 H), 6.86-6.97 (m, 2 H), 6.79 (td, 1 H), 6.65 (s, 1 H), 4.72 (br dd, 1 H), 3.59 (ddd, 1 H), 2.85-3.01 (m, 1 H), 2.73 (dd, 1 H) 403.2 [M+H] + 97.4%
1944 (CD 3OD) δ 8.29 (d, 1 H), 8.14 (s, 1 H), 7.67 (s, 1 H), 6.31-7.05 (m, 4 H), 4.36 (br s, 1 H), 3.71 (br s, 1 H), 2.96-3.14 (m, 1 H), 2.78 (br dd, 1 H), 2.44 (s, 3 H), 2.19-2.38 (m, 1 H), 0.83-1.07 (m, 4 H) 389.2 [M+H] + 94.8%
1945 (CD 3OD) δ 8.31 (d, 1 H), 8.15 (s, 1 H), 7.68 (s, 1 H), 6.55-7.05 (m, 4 H), 4.39 (br s, 1 H), 3.52-3.85 (m, 1 H), 3.06 (br s, 1 H), 2.80 (br dd, 1 H), 2.46 (s, 3 H), 2.24-2.41 (m, 1 H), 0.92-1.03 (m, 4 H) 389.2 [M+H] + 98.3%
1946 (CD 3OD) δ 9.09-9.17 (m, 1 H), 8.48 (s, 1 H), 8.23-8.37 (m, 1 H), 7.71 (s, 1 H), 7.56 (s, 0.3 H), 7.03-7.11 (m, 1 H), 6.81-6.99 (m, 1.7 H), 6.64-6.74 (m, 1 H), 4.99-5.13 (m, 1 H), 3.77-3.87 (m, 0.7 H), 3.41-3.52 (m, 0.3 H), 2.98-3.25 (m, 2 H), 2.83-2.92 (m, 1 H), 1.32-1.38 (m, 6 H) 512.2 [M+H] + 99.4%
1947 (CD 3OD) δ 9.07-9.17 (m, 1 H), 8.48 (s, 1 H), 8.24-8.35 (m, 1 H), 7.72 (s, 1 H), 7.56 (s, 0.3 H), 7.03-7.11 (m, 1 H), 6.81-6.99 (m, 1.7 H), 6.63-6.74 (m, 1 H), 5.07 (br dd, 1 H), 3.76-3.87 (m, 0.7 H), 3.45 (td, 0.3 H), 3.20 (td, 2 H), 2.80-2.92 (m, 1 H), 1.31-1.38 (m, 6 H) 512.2 [M+H] + 99.4%
1948 (CD 3OD) δ 8.11-8.22 (m, 1 H), 7.83-7.89 (m, 1 H), 7.59 (s, 1 H), 7.44 (s, 0.3 H), 6.90-6.96 (m, 1 H), 6.67-6.87 (m, 1.7 H), 6.53-6.61 (m, 1 H), 4.84-5.04 (m, 1 H), 3.77 (s, 3 H), 3.64-3.73 (m, 0.7 H), 3.32 (td, 0.3 H), 2.84-3.13 (m, 2 H), 2.68-2.79 (m, 1 H), 2.51-2.59 (m, 3 H), 1.18-1.25 (m, 6 H) 472.2 [M+H] + 98.0%
1949 (CD 3OD) δ 8.11-8.22 (m, 1 H), 7.83-7.90 (m, 1 H), 7.59 (s, 1 H), 7.43 (s, 0.3 H), 6.90-6.98 (m, 1 H), 6.66-6.86 (m, 1.7 H), 6.52-6.61 (m, 1 H), 4.98 (br dd, 1 H), 3.77 (s, 3 H), 3.63-3.72 (m, 0.7 H), 3.26-3.37 (m, 0.3 H), 2.84-3.14 (m, 2 H), 2.67-2.78 (m, 1 H), 2.52-2.59 (m, 3 H), 1.18-1.25 (m, 6 H) 472.2 [M+H] + 94.1%
1950 (CD 3OD) δ 8.23-8.36 (m, 1 H), 7.82 (d, 1 H), 7.71 (s, 1 H), 7.48-7.56 (m, 0.3 H), 7.03-7.09 (m, 1 H), 6.79-7.01 (m, 2.7 H), 6.64-6.74 (m, 1 H), 5.04 (br dd, 1 H), 4.04 (s, 3 H), 3.81 (ddd, 0.7 H), 3.45 (td, 0.3 H), 2.98-3.25 (m, 2 H), 2.82-2.91 (m, 1 H), 1.28-1.38 (m, 6 H) 458.2 [M+H] + 99.7%
1951 (CD 3OD) δ 8.24-8.36 (m, 1 H), 7.83 (d, 1 H), 7.71 (s, 1 H), 7.52 (s, 0.3 H), 7.03-7.10 (m, 1 H), 6.80-7.02 (m, 2.7 H), 6.64-6.75 (m, 1 H), 4.97-5.10 (m, 1 H), 4.04 (s, 3 H), 3.74-3.89 (m, 0.7 H), 3.41-3.51 (m, 0.3 H), 2.98-3.27 (m, 2 H), 2.81-2.91 (m, 1 H), 1.30-1.38 (m, 6 H) 458.2 [M+H] + 99.7%
1952 (CD 3OD) δ 8.36 (d, 1 H), 7.97-8.09 (m, 2 H), 7.70 (s, 1 H), 7.30 (t, 2 H), 6.93-7.01 (m, 1 H), 6.80-6.87 (m, 1 H), 6.73 (s, 1 H), 6.46 (br s, 1 H), 4.39 (dd, 1 H), 3.73-3.86 (m, 1 H), 3.03-3.19 (m, 1 H), 2.86 (br dd, 1 H) 420.1 [M+H] + 99.1%
1953 (CD 3OD) δ 8.31-8.41 (m, 1 H), 7.98-8.09 (m, 2 H), 7.67-7.75 (m, 1 H), 7.24-7.37 (m, 2 H), 6.92-7.03 (m, 1 H), 6.80-6.88 (m, 1 H), 6.73 (s, 1 H), 6.38-6.53 (m, 1 H), 4.34-4.45 (m, 1 H), 3.72-3.87 (m, 1 H), 3.04-3.18 (m, 1 H), 2.81-2.94 (m, 1 H) 420.1 [M+H] + 99.4%
1954 (CD 3OD) δ 8.34 (d, 1 H), 7.57-7.75 (m, 2 H), 6.94 (dd, 1 H), 6.78-6.90 (m, 2 H), 6.62-6.76 (m, 2 H), 6.21 (dd, 1 H), 4.52-4.59 (m, 1 H), 3.56 (ddd, 1 H), 2.89-3.02 (m, 1 H), 2.62-2.77 (m, 1 H) 353.1 [M+H] + 99.8%
1955 (CD 3OD) δ 8.34 (d, 1 H), 7.59-7.72 (m, 2 H), 6.94 (dd, 1 H), 6.77-6.89 (m, 2 H), 6.60-6.76 (m, 2 H), 6.21 (dd, 1 H), 4.58 (br s, 1 H), 3.49-3.64 (m, 1 H), 2.84-3.03 (m, 1 H), 2.70 (br dd, 1 H) 353.1 [M+H] + 99.6%
1956 (CD 3OD) δ 8.22-8.50 (m, 1 H), 7.54-8.13 (m, 2 H), 7.48 (d, 1 H), 7.02-7.34 (m, 1 H), 6.76 (br d, 1.6 H), 6.33-6.65 (m, 1.4 H), 4.60-4.71 (m, 0.5 H), 4.34 (br s, 0.5 H), 3.66 (br s, 0.5 H), 3.27-3.37 (m, 0.5 H), 2.80-3.07 (m, 1 H), 2.73 (br d, 1 H), 1.58-2.02 (m, 6 H) 395.2 [M+H] + 99.1%
1957 (CD 3OD) δ 8.35 (br s, 1 H), 7.91 (br s, 0.4 H), 7.54-7.73 (m, 1.6 H), 7.49 (d, 1 H), 7.02-7.20 (m, 1 H), 6.76 (br s, 1.6 H), 6.31-6.63 (m, 1.4 H), 4.57-4.70 (m, 0.5 H), 4.19-4.42 (m, 0.5 H), 3.66 (br s, 0.6 H), 3.27-3.34 (m, 0.4 H), 2.99 (br s, 1 H), 2.73 (br d, 1 H), 1.72 (br d, 6 H) 395.2 [M+H] + 99.3%
1958 (CD 3OD) δ 8.20 (br s, 1 H), 7.90 (br s, 0.5 H), 7.48-7.72 (m, 1.5 H), 6.89 (br d, 1 H), 6.61-6.83 (m, 1.6 H), 6.32-6.59 (m, 1.4 H), 4.58-4.71 (m, 0.5 H), 4.35 (br s, 0.5 H), 3.66 (br s, 0.5 H), 3.25-3.36 (m, 0.5 H), 2.82-3.11 (m, 1 H), 2.72 (br s, 1 H), 2.34 (s, 3 H), 1.57-1.87 (m, 6 H) 409.2 [M+H] + 99.6%
1959 (CD 3OD) δ 8.06-8.33 (m, 1 H), 7.91 (br s, 0.5 H), 7.50-7.72 (m, 1.5 H), 6.89 (br d, 1 H), 6.63-6.83 (m, 1.5 H), 6.34-6.61 (m, 1.5 H), 4.56-4.69 (m, 0.5 H), 4.25-4.42 (m, 0.5 H), 3.52-3.73 (m, 0.5 H), 3.27 (br d, 0.5 H), 2.80-3.08 (m, 1 H), 2.73 (br d, 1 H), 2.34 (s, 3 H), 1.55-1.83 (m, 6 H) 409.2 [M+H] + 99.4%
1960 (CD 3OD) δ 8.28 (br s, 2 H), 7.73-8.16 (m, 2 H), 7.70 (s, 1 H), 7.00 (br d, 1 H), 6.70-6.96 (m, 2 H), 6.63 (br s, 1 H), 4.62 (br s, 1 H), 3.98 (s, 3 H), 3.80 (br s, 0.5 H), 3.37-3.54 (m, 0.5 H), 2.78-3.22 (m, 2 H), 2.45 (s, 3 H) 429.2 [M+H] + 98.3%
1961 (CD 3OD) δ 8.04-8.35 (m, 2 H), 7.64-8.02 (m, 2 H), 7.59 (s, 1 H), 6.89 (br d, 1 H), 6.56-6.83 (m, 2 H), 6.51 (br s, 1 H), 4.49 (br s, 1 H), 3.86 (s, 3 H), 3.68 (br s, 0.5 H), 3.25-3.43 (m, 0.5 H), 2.58-3.12 (m, 2 H), 2.34 (s, 3 H) 429.2 [M+H] + 89.5%
1962 (CD 3OD) δ 8.23 (br s, 1 H), 7.67-8.02 (m, 2 H), 7.64 (s, 1 H), 6.89 (br d, 1 H), 6.57-6.84 (m, 2 H), 6.50 (br s, 1 H), 4.60-4.69 (m, 1 H), 3.74 (br s, 3 H), 3.24-3.68 (m, 1 H), 2.63-3.12 (m, 2 H), 2.52 (br d, 3 H), 2.34 (s, 3 H) 443.2 [M+H] + 100%
1963 (CD 3OD) δ 8.23 (br s, 1 H), 7.82 (br s, 2 H), 7.65 (br s, 1 H), 6.89 (br d, 1 H), 6.58-6.84 (m, 2 H), 6.51 (br s, 1 H), 4.56-4.68 (m, 1 H), 3.74 (br s, 3 H), 3.25-3.69 (m, 1 H), 2.69-3.08 (m, 2 H), 2.39-2.63 (m, 3 H), 2.34 (s, 3 H) 443.2 [M+H] + 99.0%
1964 (CD 3OD) δ 8.68-8.76 (m, 1 H), 8.33 (br s, 1 H), 8.23 (br d, 1.5 H), 7.87-8.10 (m, 1.5 H), 7.71 (br s, 1 H), 7.52-7.63 (m, 1 H), 7.01 (br d, 1 H), 6.57-6.97 (m, 3 H), 4.70-4.82 (m, 1 H), 3.41-3.95 (m, 1 H), 2.96-3.28 (m, 1 H), 2.86 (br s, 1 H), 2.47 (s, 3 H) 426.2 [M+H] + 100%
1965 (CD 3OD) δ 8.73 (d, 1 H), 8.33 (br s, 1 H), 8.24 (br s, 1.5 H), 7.87-8.10 (m, 1.5 H), 7.70 (br s, 1 H), 7.59 (dd, 1 H), 7.01 (br d, 1 H), 6.55-6.97 (m, 3 H), 4.63-4.80 (m, 1 H), 3.43-3.91 (m, 1 H), 2.95-3.28 (m, 1 H), 2.86 (br s, 1 H), 2.47 (s, 3 H) 426.2 [M+H] + 99.9%
1966 (CD 3OD) δ 8.69 (br d, 1 H), 8.29-8.54 (m, 2 H), 8.02 (td, 1 H), 7.66-7.83 (m, 1.3 H), 7.48-7.66 (m, 2 H), 7.08-7.32 (m, 1 H), 6.75-7.06 (m, 1.7 H), 6.50-6.72 (m, 1 H), 5.13 (dd, 1 H), 3.66-3.88 (m, 0.6 H), 3.45 (td, 0.4 H), 2.95-3.28 (m, 1 H), 2.83 (dd, 1 H) 429.1 [M+H] + 100%
1967 (CD 3OD) δ 8.70 (br d, 1 H), 8.25-8.53 (m, 2 H), 8.02 (td, 1 H), 7.47-7.87 (m, 3.3 H), 7.11-7.32 (m, 1 H), 6.77-7.04 (m, 1.7 H), 6.51-6.72 (m, 1 H), 5.13 (dd, 1 H), 3.65-3.89 (m, 0.7 H), 3.45 (td, 0.3 H), 2.97-3.27 (m, 1 H), 2.84 (dd, 1 H) 429.1 [M+H] + 99.8%
1968 (CD 3OD) δ 8.70 (br d, 1 H), 8.25-8.45 (m, 2 H), 7.92-8.11 (m, 1 H), 7.65-7.82 (m, 1.4 H), 7.57 (dd, 1 H), 6.90-7.04 (m, 1.6 H), 6.70-6.90 (m, 2 H), 5.17 (dd, 1 H), 3.77 (ddd, 0.6 H), 3.44 (td, 0.4 H), 2.96-3.27 (m, 1 H), 2.84 (dd, 1 H) 447.1 [M+H] + 100%
1969 (CD 3OD) δ 8.58 (br d, 1 H), 8.08-8.35 (m, 2 H), 7.79-8.00 (m, 1 H), 7.64 (br s, 1.4 H), 7.45 (dd, 1 H), 6.44-7.08 (m, 3.6 H), 5.06 (br dd, 1 H), 3.57-3.76 (m, 0.6 H), 3.32 (td, 0.4 H), 2.85-3.16 (m, 1 H), 2.73 (br dd, 1 H) 447.1 [M+H] + 99.8%
1970 (CD 3OD) δ 8.46-9.12 (m, 1 H), 8.19-8.43 (m, 2 H), 8.01 (td, 1 H), 7.64-7.87 (m, 1.3 H), 7.56 (dd, 1 H), 6.98 (q, 1.7 H), 6.71-6.84 (m, 1 H), 6.52-6.69 (m, 1 H), 5.13 (dd, 1 H), 3.69-3.85 (m, 0.7 H), 3.40-3.51 (m, 0.3 H), 2.96-3.27 (m, 1 H), 2.84 (dd, 1 H), 2.29-2.56 (m, 3 H) 443.1 [M+H] + 100%
1971 (CD 3OD) δ 8.51-9.00 (m, 1 H), 8.19-8.48 (m, 2 H), 7.92-8.15 (m, 1 H), 7.47-7.86 (m, 2.3 H), 6.92-7.11 (m, 1.7 H), 6.71-6.89 (m, 1 H), 6.51-6.69 (m, 1 H), 5.13 (br dd, 1 H), 3.71-3.85 (m, 0.7 H), 3.41-3.50 (m, 0.3 H), 2.96-3.27 (m, 1 H), 2.84 (br dd, 1 H), 2.39-2.53 (m, 3 H) 443.2 [M+H] + 100%
1972 (CD 3OD) δ 9.46-9.54 (m, 2 H), 9.41 (s, 1 H), 8.26-8.36 (m, 1 H), 7.72-7.79 (m, 1 H), 7.56 (s, 0.3 H), 6.98-7.05 (m, 1.7 H), 6.77-6.85 (m, 1 H), 6.59-6.69 (m, 1 H), 5.11 (br d, 1 H), 3.80-3.87 (m, 0.7 H), 3.50 (br d, 0.3 H), 3.16-3.24 (m, 0.7 H), 3.00-3.05 (m, 0.3 H), 2.84-2.92 (m, 1 H), 2.43-2.49 (m, 3 H) 428.2 [M+H] + 99.9%
1973 (CD 3OD) δ 9.46-9.52 (m, 2 H), 9.40 (s, 1 H), 8.26-8.35 (m, 1 H), 7.72 (s, 1 H), 7.55 (br s, 0.3 H), 7.01 (br t, 1.7 H), 6.77-6.84 (m, 1 H), 6.60-6.68 (m, 1 H), 5.09 (br d, 1 H), 3.83 (ddd, 0.7 H), 3.46-3.52 (m, 0.3 H), 3.15-3.27 (m, 0.7 H), 2.98-3.08 (m, 0.3 H), 2.83-2.93 (m, 1 H), 2.42-2.49 (m, 3 H) 428.1 [M+H] + 98.8%
1974 (CD 3OD) δ 9.47-9.53 (m, 2 H), 9.40 (s, 1 H), 8.31-8.39 (m, 1 H), 7.72 (s, 1 H), 7.51-7.60 (m, 0.3 H), 6.95-7.02 (m, 1.7 H), 6.81-6.90 (m, 1 H), 6.75-6.80 (m, 1 H), 5.11 (m, 1 H), 3.75-3.90 (m, 0.7 H), 3.39-3.51 (m, 0.3 H), 3.16-3.26 (m, 0.7 H), 2.99-3.05 (m, 0.3 H), 2.83-2.94 (m, 1 H) 432.2 [M+H] + 99.7%
1975 (CD 3OD) δ 9.44-9.55 (m, 2 H), 9.40 (s, 1 H), 8.30-8.40 (m, 1 H), 7.72 (s, 1 H), 7.56 (s, 0.3 H), 6.94-7.04 (m, 1.7 H), 6.82-6.90 (m, 1 H), 6.76-6.81 (m, 1 H), 5.11 (br d, 1 H), 3.78-3.87 (m, 0.7 H), 3.46 (br d, 0.3 H), 3.17-3.27 (m, 0.7 H), 2.97-3.05 (m, 0.3 H), 2.90 (br s, 1 H) 432.1 [M+H] + 98.9%
1976 (CD 3OD) δ 8.34 (d, 1 H), 8.07-8.18 (m, 1 H), 7.63 (s, 1 H), 7.54-7.61 (m, 1 H), 7.05 (d, 1 H), 6.94 (dd, 1 H), 6.76-6.85 (m, 2 H), 6.67 (dd, 1 H), 6.63 (s, 1 H), 4.57 (dd, 1 H), 3.52-3.64 (m, 1 H), 2.88-3.05 (m, 1 H), 2.69 (dd, 1 H) 335.1 [M+H] + 99.7%
1977 (CD 3OD) δ 8.34 (d, 1 H), 8.10-8.17 (m, 1 H), 7.62 (s, 1 H), 7.55-7.61 (m, 1 H), 7.05 (d, 1 H), 6.94 (dd, 1 H), 6.76-6.86 (m, 2 H), 6.67 (dd, 1 H), 6.63 (s, 1 H), 4.52-4.60 (m, 1 H), 3.51-3.63 (m, 1 H), 2.88-3.03 (m, 1 H), 2.69 (dd, 1 H) 335.2 [M+H] + 98.6%
1978 (CD 3OD) δ 8.58 (br d, 1 H), 8.13 (dd, 1 H), 7.54-7.66 (m, 2 H), 7.41 (br d, 1 H), 6.74-7.13 (m, 4 H), 6.62-6.72 (m, 2 H), 4.56 (br d, 1 H), 3.49-3.61 (m, 1 H), 2.90-3.03 (m, 1 H), 2.69 (br dd, 1 H) 367.2 [M+H] + 98.9%
1979 (CD 3OD) δ 8.58 (br d, 1 H), 8.13 (dd, 1 H), 7.54-7.67 (m, 2 H), 7.41 (br d, 1 H), 6.75-7.12 (m, 4 H), 6.63-6.71 (m, 2 H), 4.55 (br s, 1 H), 3.56 (ddd, 1 H), 2.89-3.03 (m, 1 H), 2.69 (br dd, 1 H) 367.1 [M+H] + 96.6%
1980 (CD 3OD) δ 9.04 (br d, 2 H), 8.22-8.38 (m, 1 H), 7.66-7.79 (m, 2 H), 7.46 (br s, 0.3 H), 6.95-7.13 (m, 1.7 H), 6.69-6.89 (m, 2 H), 5.00-5.02 (m, 1 H), 3.76-3.90 (m, 0.6 H), 3.44-3.51 (m, 0.4 H), 2.97-3.27 (m, 2 H), 2.88 (br d, 1 H), 1.30-1.42 (m, 6 H) 456.2 [M+H] + 99.6%
1981 (CD 3OD) δ 9.02-9.08 (m, 2 H), 8.23-8.36 (m, 1 H), 7.68-7.75 (m, 2 H), 7.41-7.49 (m, 0.3 H), 6.97-7.11 (m, 1.7 H), 6.69-6.88 (m, 2 H), 4.99-5.03 (m, 1 H), 3.79-3.88 (m, 0.6 H), 3.43-3.53 (m, 0.4 H), 2.99-3.27 (m, 2 H), 2.88 (br d, 1 H), 1.31-1.38 (m, 6 H) 456.2 [M+H] + 99.0%
1982 (CD 3OD) δ 8.22-8.39 (m, 2 H), 7.49-7.86 (m, 2.3 H), 7.23 (d, 1 H), 6.95-7.11 (m, 1.7 H), 6.64-6.89 (m, 2 H), 5.04 (br dd, 1 H), 3.77-3.88 (m, 0.6 H), 3.42-3.52 (m, 0.4 H), 3.21 (tt, 2 H), 2.83-2.93 (m, 1 H), 1.30-1.39 (m, 6 H) 494.2 [M+H] + 100%
1983 (CD 3OD) δ 8.22-8.37 (m, 2 H), 7.47-7.86 (m, 2.3 H), 7.24 (d, 1 H), 6.96-7.11 (m, 1.7 H), 6.63-6.90 (m, 2 H), 5.04 (br dd, 1 H), 3.77-3.89 (m, 0.6 H), 3.41-3.52 (m, 0.4 H), 2.99-3.27 (m, 2 H), 2.83-2.92 (m, 1 H), 1.31-1.38 (m, 6 H) 494.2 [M+H] + 100%
1984 (CD 3OD) δ 8.52 (d, 1 H), 8.21-8.37 (m, 2 H), 7.63 (s, 0.3 H), 7.29 (d, 1 H), 7.10 (br t, 1.7 H), 6.78-6.91 (m, 2 H), 5.13 (br dd, 1 H), 3.77-3.86 (m, 0.6 H), 3.42-3.53 (m, 0.4 H), 3.03-3.29 (m, 2 H), 2.95 (br d, 1 H), 1.32-1.38 (m, 6 H) 512.2 [M+H] + 100%
1985 (CD 3OD) δ 8.40 (d, 1 H), 8.12-8.26 (m, 1 H), 7.60 (br s, 1 H), 7.40 (br s, 0.3 H), 7.17 (d, 1 H), 6.84-7.00 (m, 1.7 H), 6.54-6.77 (m, 2 H), 4.90-4.95 (m, 1 H), 3.65-3.75 (m, 0.6 H), 3.29-3.39 (m, 0.4 H), 2.90-3.14 (m, 2 H), 2.70-2.81 (m, 1 H), 1.20-1.26 (m, 6 H) 512.2 [M+H] + 99.7%
1986 (CD 3OD) δ 8.34 (d, 1 H), 8.14 (s, 1 H), 7.67 (s, 1 H), 6.42-7.07 (m, 4 H), 4.18-4.57 (m, 1 H), 3.70 (br s, 1 H), 2.93-3.18 (m, 1 H), 2.79 (br dd, 1 H), 2.20-2.45 (m, 1 H), 0.83-1.13 (m, 4 H) 393.2 [M+H] + 99.2%
1987 (CD 3OD) δ 8.34 (d, 1 H), 8.14 (s, 1 H), 7.67 (s, 1 H), 6.46-7.05 (m, 4 H), 4.38 (br s, 1 H), 3.54-3.84 (m, 1 H), 3.01-3.15 (m, 1 H), 2.72-2.86 (m, 1 H), 2.35 (br s, 1 H), 0.91-1.00 (m, 4 H) 393.2 [M+H] + 98.0%
1988 (CD 3OD) δ 8.23-8.32 (m, 1 H), 8.08-8.12 (m, 1 H), 7.65-7.73 (m, 1.3 H), 7.37-7.43 (m, 1 H), 6.81-7.14 (m, 1.7 H), 6.71-6.80 (m, 1 H), 6.49-6.64 (m, 1 H), 5.04 (dd, 1 H), 3.69 (ddd, 0.7 H), 3.33-3.40 (m, 0.3 H), 3.07-3.18 (m, 0.7 H), 2.90-3.00 (m, 0.3 H), 2.78 (dd, 1 H), 2.36-2.47 (m, 3 H) 349.2 [M+H] + 100%
1989 (CD 3OD) δ 8.25-8.31 (m, 1 H), 8.09-8.12 (m, 1 H), 7.68 (s, 1 H), 7.38-7.44 (m, 1 H), 6.93-7.00 (m, 2 H), 6.73-6.81 (m, 1 H), 6.47-6.63 (m, 1 H), 4.94-5.08 (m, 1 H), 3.69 (ddd, 0.7 H), 3.35-3.41 (m, 0.3 H), 3.08-3.18 (m, 0.7 H), 2.90-2.98 (m, 0.3 H), 2.78 (dd, 1 H), 2.38-2.47 (m, 3 H) 349.1 [M+H] + 99.4%
1990 (CD 3OD) δ 8.39-8.52 (m, 1 H), 7.65-7.80 (m, 1.3 H), 7.53-7.64 (m, 1 H), 7.14-7.27 (m, 1 H), 6.79-6.99 (m, 1.7 H), 6.51-6.67 (m, 1 H), 5.14 (br dd, 0.5 H), 4.79-4.87 (m, 0.5 H), 3.62-3.78 (m, 0.5 H), 3.36-3.48 (m, 0.5 H), 2.91-3.22 (m, 1 H), 2.80 (br d, 1 H), 2.48-2.63 (m, 1 H), 1.12-1.43 (m, 4 H) 392.1 [M+H] + 100%
1991 (CD 3OD) δ 8.37-8.50 (m, 1 H), 7.65-7.78 (m, 1.3 H), 7.53-7.64 (m, 1 H), 7.12-7.27 (m, 1 H), 6.79-6.98 (m, 1.7 H), 6.51-6.68 (m, 1 H), 5.14 (dd, 0.5 H), 4.79-4.86 (m, 0.5 H), 3.64-3.78 (m, 0.5 H), 3.36-3.47 (m, 0.5 H), 2.92-3.21 (m, 1 H), 2.80 (br dd, 1 H), 2.49-2.63 (m, 1 H), 1.16-1.40 (m, 4 H) 392.1 [M+H] + 96.4%
1992 (CD 3OD) δ 8.28-8.40 (m, 1 H), 7.66-7.78 (m, 1.3 H), 6.89-7.03 (m, 1.7 H), 6.79-6.89 (m, 1 H), 6.69-6.77 (m, 1 H), 5.17 (dd, 0.5 H), 4.85 (br d, 0.5 H), 3.66-3.78 (m, 0.5 H), 3.36-3.46 (m, 0.5 H), 2.92-3.21 (m, 1 H), 2.81 (dd, 1 H), 2.51-2.62 (m, 1 H), 1.17-1.40 (m, 4 H) 410.1 [M+H] + 99.6%
1993 (CD 3OD) δ 8.26-8.42 (m, 1 H), 7.66-7.77 (m, 1.3 H), 6.89-7.04 (m, 1.7 H), 6.78-6.89 (m, 1 H), 6.67-6.77 (m, 1 H), 5.17 (dd, 0.5 H), 4.85 (br d, 0.5 H), 3.71 (ddd, 0.5 H), 3.36-3.49 (m, 0.5 H), 2.92-3.20 (m, 1 H), 2.81 (dd, 1 H), 2.49-2.63 (m, 1 H), 1.17-1.41 (m, 4 H) 410.1 [M+H] + 88.5%
1994 (CD 3OD) δ 8.20-8.43 (m, 1 H), 7.63-7.84 (m, 2 H), 6.65-7.03 (m, 5 H), 5.22 (dd, 1 H), 3.99 (s, 3 H), 3.65-3.79 (m, 0.6 H), 3.42 (td, 0.4 H), 2.92-3.24 (m, 1 H), 2.82 (br dd, 1 H) 450.1 [M+H] + 99.2%
1995 (CD 3OD) δ 8.17-8.41 (m, 1 H), 7.51-7.84 (m, 2 H), 6.60-7.02 (m, 5 H), 5.22 (dd, 1 H), 3.98 (s, 3 H), 3.65-3.78 (m, 0.6 H), 3.37-3.50 (m, 0.4 H), 2.94-3.25 (m, 1 H), 2.73-2.89 (m, 1 H) 450.1 [M+H] + 99.1%
1996 (CD 3OD) δ 8.24-8.37 (m, 1 H), 7.64-7.78 (m, 1.3 H), 6.90-7.05 (m, 1.7 H), 6.74-6.84 (m, 1 H), 6.51-6.65 (m, 1 H), 5.14 (dd, 0.5 H), 4.80-4.87 (m, 0.5 H), 3.72 (ddd, 0.5 H), 3.42 (td, 0.5 H), 2.93-3.21 (m, 1 H), 2.80 (dd, 1 H), 2.52-2.63 (m, 1 H), 2.40-2.50 (m, 3 H), 1.16-1.41 (m, 4 H) 406.2 [M+H] + 100%
1997 (CD 3OD) δ 8.25-8.37 (m, 1 H), 7.65-7.77 (m, 1.3 H), 6.89-7.05 (m, 1.7 H), 6.73-6.84 (m, 1 H), 6.54-6.66 (m, 1 H), 5.14 (dd, 0.5 H), 4.79-4.86 (m, 0.5 H), 3.65-3.78 (m, 0.5 H), 3.37-3.48 (m, 0.5 H), 2.93-3.22 (m, 1 H), 2.80 (dd, 1 H), 2.51-2.63 (m, 1 H), 2.39-2.50 (m, 3 H), 1.16-1.42 (m, 4 H) 406.2 [M+H] + 99.6%
1998 (CD 3OD) δ 8.18-8.39 (m, 1 H), 7.59-7.82 (m, 2.5 H), 6.85-7.02 (m, 2.5 H), 6.69-6.81 (m, 1 H), 6.50-6.66 (m, 1 H), 5.18 (dd, 1 H), 3.98 (s, 3 H), 3.65-3.84 (m, 0.7 H), 3.43 (td, 0.3 H), 2.92-3.24 (m, 1 H), 2.81 (br dd, 1 H), 2.34-2.48 (m, 3 H) 446.2 [M+H] + 99.1%
1999 (CD 3OD) δ 8.15-8.36 (m, 1 H), 7.54-7.80 (m, 2.5 H), 6.86-7.04 (m, 2.5 H), 6.70-6.82 (m, 1 H), 6.45-6.67 (m, 1 H), 5.18 (dd, 1 H), 3.98 (s, 3 H), 3.67-3.80 (m, 0.6 H), 3.43 (td, 0.4 H), 2.94-3.24 (m, 1 H), 2.81 (br dd, 1 H), 2.32-2.50 (m, 3 H) 446.2 [M+H] + 98.8%
2000 (CD 3OD) δ 8.37-8.51 (m, 1 H), 8.01-8.27 (m, 2.5 H), 7.68 (d, 1 H), 7.46-7.64 (m, 3 H), 7.06-7.31 (m, 1 H), 6.98 (s, 0.5 H), 6.74-6.91 (m, 1 H), 6.47-6.71 (m, 1 H), 5.49 (dd, 0.5 H), 4.90-4.95 (m, 0.5 H), 3.64-3.81 (m, 0.7 H), 3.36-3.56 (m, 0.3 H), 3.10 (s, 1 H), 2.82 (br d, 1 H) 401.1 [M+H] + 100%
2001 (CD 3OD) δ 8.38-8.50 (m, 1 H), 8.05-8.27 (m, 2.5 H), 7.69 (s, 1 H), 7.49-7.66 (m, 3 H), 7.08-7.27 (m, 1 H), 6.99 (s, 0.5 H), 6.73-6.92 (m, 1 H), 6.44-6.71 (m, 1 H), 5.35-5.59 (m, 0.5 H), 4.93 (s, 0.5 H), 3.64-3.85 (m, 0.5 H), 3.32-3.51 (m, 0.5 H), 2.98-3.20 (m, 1 H), 2.72-2.87 (m, 1 H) 401.1 [M+H] + 99.4%
2002 (CD 3OD) δ 8.18-8.46 (m, 1.4 H), 7.94-8.16 (m, 2 H), 7.69 (s, 1 H), 7.58 (dq, 2 H), 6.89-7.08 (m, 1.6 H), 6.62-6.88 (m, 2 H), 5.53 (br dd, 0.5 H), 4.93-5.05 (m, 0.5 H), 3.73 (td, 0.6 H), 3.38-3.52 (m, 0.4 H), 2.95-3.25 (m, 1 H), 2.82 (br d, 1 H) 419.1 [M+H] + 100%
2003 (CD 3OD) δ 8.20-8.44 (m, 1.5 H), 8.00-8.19 (m, 2 H), 7.69 (s, 1 H), 7.46-7.63 (m, 2 H), 6.88-7.09 (m, 1.5 H), 6.58-6.87 (m, 2 H), 5.53 (br dd, 0.5 H), 4.94-4.99 (m, 0.5 H), 3.66-3.76 (m, 0.6 H), 3.40-3.49 (m, 0.4 H), 2.94-3.25 (m, 1 H), 2.77-2.88 (m, 1 H) 419.1 [M+H] + 99.6%
2004 (CD 3OD) δ 8.28-8.55 (m, 1 H), 7.42-7.92 (m, 3.4 H), 7.14-7.26 (m, 1 H), 7.05-7.10 (m, 1 H), 6.96 (br s, 0.6 H), 6.81-6.89 (m, 1 H), 6.47-6.76 (m, 1 H), 5.04 (br dd, 1 H), 4.22-4.41 (m, 3 H), 3.39-3.86 (m, 1 H), 2.95-3.26 (m, 1 H), 2.75-2.93 (m, 1 H) 416.2 [M+H] + 98.4%
2005 (CD 3OD) δ 8.33-8.55 (m, 1 H), 7.48-7.78 (m, 3.3 H), 7.14-7.24 (m, 1 H), 7.05-7.10 (m, 1 H), 6.96 (s, 0.7 H), 6.78-6.89 (m, 1 H), 6.55-6.68 (m, 1 H), 5.04 (dd, 1 H), 4.23-4.37 (m, 3 H), 3.74-3.85 (m, 0.6 H), 3.37-3.45 (m, 0.4 H), 2.94-3.24 (m, 1 H), 2.78-2.90 (m, 1 H) 416.2 [M+H] + 97.6%
2006 (CD 3OD) δ 8.22-8.37 (m, 1 H), 7.64-7.75 (m, 1 H), 7.51 (s, 0.3 H), 6.95-7.22 (m, 1.7 H), 6.63-6.92 (m, 3 H), 5.02 (br dd, 1 H), 3.88-3.96 (m, 3 H), 3.75-3.86 (m, 0.6 H), 3.40-3.48 (m, 0.4 H), 2.98-3.27 (m, 2 H), 2.86 (br d, 1 H), 2.41 (s, 3 H), 1.30-1.39 (m, 6 H) 472.2 [M+H] + 100%
2007 (CD 3OD) δ 8.24-8.36 (m, 1 H), 7.63-7.74 (m, 1 H), 7.51 (s, 0.3 H), 6.96-7.22 (m, 1.7 H), 6.60-6.92 (m, 3 H), 4.99-5.07 (m, 1 H), 3.88-3.96 (m, 3 H), 3.75-3.85 (m, 0.6 H), 3.40-3.49 (m, 0.4 H), 2.97-3.27 (m, 2 H), 2.86 (br d, 1 H), 2.41 (s, 3 H), 1.31-1.39 (m, 6 H) 472.2 [M+H] + 100%
2008 (CD 3OD) δ 8.46 (d, 1 H), 7.99-8.06 (m, 2 H), 7.70 (s, 1 H), 7.26-7.34 (m, 3 H), 6.85 (t, 1 H), 6.72 (s, 1 H), 6.42-6.49 (m, 1 H), 4.39 (dd, 1 H), 3.79 (ddd, 1 H), 3.05-3.16 (m, 1 H), 2.81-2.92 (m, 1 H) 436.1 [M+H] + 99.1%
2009 (CD 3OD) δ 8.45 (d, 1 H), 7.96-8.12 (m, 2 H), 7.70 (s, 1 H), 7.16-7.40 (m, 3 H), 6.85 (t, 1 H), 6.72 (s, 1 H), 6.45 (br s, 1 H), 4.39 (dd, 1 H), 3.71-3.84 (m, 1 H), 3.04-3.16 (m, 1 H), 2.80-2.91 (m, 1 H) 436.1 [M+H] + 99.3%
2010 (CD 3OD) δ 7.97-8.14 (m, 2 H), 7.68 (s, 1 H), 7.47 (d, 1 H), 7.30 (t, 2 H), 7.12 (dd, 1 H), 6.71 (d, 1 H), 6.53 (s, 1 H), 6.46 (s, 1 H), 4.36 (dd, 1 H), 3.82 (td, 1 H), 3.04-3.15 (m, 1 H), 2.81-2.91 (m, 1 H), 2.63 (s, 3 H) 416.2 [M+H] + 100%
2011 (CD 3OD) δ 7.99-8.08 (m, 2 H), 7.68 (s, 1 H), 7.47 (d, 1 H), 7.25-7.34 (m, 2 H), 7.12 (dd, 1 H), 6.71 (d, 1 H), 6.53 (s, 1 H), 6.46 (s, 1 H), 4.36 (dd, 1 H), 3.76-3.88 (m, 1 H), 3.03-3.17 (m, 1 H), 2.86 (dd, 1 H), 2.63 (s, 3 H) 416.2 [M+H] + 99.6%
2012 (CD 3OD) δ 8.69 (d, 1 H), 8.43 (s, 1 H), 7.78 (dd, 1 H), 7.57-7.70 (m, 2 H), 7.16 (d, 1 H), 6.91-7.01 (m, 2 H), 6.70 (s, 1 H), 4.74 (br dd, 1 H), 3.53-3.67 (m, 1 H), 2.89-3.03 (m, 1 H), 2.75 (dd, 1 H) 453.1 [M+H] + 100%
2013 (CD 3OD) δ 8.57 (d, 1 H), 8.31 (s, 1 H), 7.66 (dd, 1 H), 7.44-7.57 (m, 2 H), 7.04 (d, 1 H), 6.85 (br t, 2 H), 6.58 (s, 1 H), 4.62 (br dd, 1 H), 3.43-3.54 (m, 1 H), 2.76-2.91 (m, 1 H), 2.63 (dd, 1 H) 453.2 [M+H] + 79.7%
2014 (CD 3OD) δ 8.69 (d, 1 H), 8.13 (s, 1 H), 7.53-7.75 (m, 2 H), 6.45-7.12 (m, 3 H), 4.39 (br s, 1 H), 3.37-3.87 (m, 1 H), 3.05 (br s, 1 H), 2.71-2.86 (m, 1 H), 2.36 (br s, 1 H), 0.89-1.03 (m, 4 H) 443.2 [M+H] + 99.9%
2015 (CD 3OD) δ 8.68 (d, 1 H), 8.13 (s, 1 H), 7.55-7.74 (m, 2 H), 6.51-7.06 (m, 3 H), 4.41 (br s, 1 H), 3.39-3.85 (m, 1 H), 3.05 (br s, 1 H), 2.79 (br dd, 1 H), 2.36 (br s, 1 H), 0.74-1.15 (m, 4 H) 443.2 [M+H] + 98.8%
2016 (CD 3OD) δ 8.31-8.53 (m, 1 H), 7.54-7.89 (m, 3 H), 7.09-7.29 (m, 1 H), 6.75-7.02 (m, 3 H), 6.48-6.69 (m, 1 H), 5.18 (br d, 1 H), 3.98 (s, 3 H), 3.72 (br t, 0.5 H), 3.40 (br d, 0.5 H), 2.72-3.25 (m, 2 H) 432.1 [M+H] + 100%
2017 (CD 3OD) δ 8.29-8.53 (m, 1 H), 7.50-7.83 (m, 3 H), 7.09-7.26 (m, 1 H), 6.77-6.97 (m, 3 H), 6.50-6.67 (m, 1 H), 5.18 (br dd, 1 H), 3.98 (s, 3 H), 3.59-3.83 (m, 0.5 H), 3.42 (td, 0.5 H), 2.93-3.23 (m, 1 H), 2.81 (br dd, 1 H) 432.1 [M+H] + 98.0%
2018 (CD 3OD) δ 8.28-8.41 (m, 2 H), 8.08 (s, 1 H), 7.84 (s, 0.3 H), 7.65-7.76 (m, 1 H), 6.91-7.03 (m, 1.7 H), 6.72-6.90 (m, 2 H), 5.29 (dd, 0.6 H), 4.93-4.99 (m, 0.4 H), 4.00 (s, 3 H), 3.68-3.80 (m, 0.6 H), 3.45 (td, 0.4 H), 2.95-3.23 (m, 1 H), 2.77-2.90 (m, 1 H) 450.2 [M+H] + 100%
2019 (CD 3OD) δ 8.28-8.40 (m, 2 H), 8.08 (s, 1 H), 7.84 (s, 0.3 H), 7.71 (s, 1 H), 6.89-7.03 (m, 1.7 H), 6.69-6.88 (m, 2 H), 5.29 (dd, 0.6 H), 4.93-4.98 (m, 0.4 H), 4.00 (d, 3 H), 3.68-3.81 (m, 0.6 H), 3.45 (td, 0.4 H), 2.96-3.24 (m, 1 H), 2.84 (br d, 1 H) 450.1 [M+H] + 99.8%
2020 (CD 3OD) δ 8.19-8.44 (m, 1 H), 7.83-7.97 (m, 1 H), 7.63-7.82 (m, 2 H), 7.43-7.62 (m, 2.2 H), 6.93-7.13 (m, 1.8 H), 6.72-6.89 (m, 1 H), 6.42-6.71 (m, 1 H), 5.00 (br d, 1 H), 3.70-3.90 (m, 0.5 H), 3.39-3.49 (m, 0.5 H), 2.96-3.29 (m, 1 H), 2.78-2.91 (m, 1 H), 2.37-2.55 (m, 3 H) 399.2 [M+H] + 100%
2021 (CD 3OD) δ 8.20-8.39 (m, 1 H), 7.82-7.96 (m, 1 H), 7.62-7.79 (m, 2 H), 7.40-7.61 (m, 2.2 H), 6.91-7.11 (m, 1.8 H), 6.71-6.85 (m, 1 H), 6.41-6.70 (m, 1 H), 4.98-5.03 (m, 1 H), 3.67-3.87 (m, 0.5 H), 3.36-3.47 (m, 0.5 H), 2.97-3.26 (m, 1 H), 2.73-2.90 (m, 1 H), 2.31-2.55 (m, 3 H) 399.2 [M+H] + 98.2%
2022 (DMSO- d 6) δ 12.00-12.33 (m, 1 H), 8.59-9.05 (m, 1 H), 7.93-8.32 (m, 2.5 H), 7.44-7.77 (m, 4 H), 7.05-7.35 (m, 1 H), 6.85-7.04 (m, 1 H), 6.57-6.81 (m, 1.5 H), 5.40-5.56 (m, 0.6 H), 4.76-4.91 (m, 0.4 H), 3.62-3.78 (m, 0.6 H), 3.24-3.30 (m, 0.4 H), 2.73-3.11 (m, 2 H) 451.2 [M+H] + 100%
2023 (DMSO- d 6) δ 11.96-12.33 (m, 1 H), 8.65-8.97 (m, 1 H), 7.94-8.37 (m, 2.5 H), 7.44-7.71 (m, 4 H), 7.09-7.44 (m, 1 H), 6.87-7.04 (m, 1 H), 6.64-6.84 (m, 1.5 H), 5.33-5.63 (m, 0.6 H), 4.84 (br dd, 0.4 H), 3.51-3.78 (m, 0.5 H), 3.22-3.31 (m, 0.5 H), 2.72-3.12 (m, 2 H) 451.1 [M+H] + 99.8%
2024 (CD 3OD) δ 8.21-8.40 (m, 1 H), 7.64 (d, 1 H), 6.92-7.01 (m, 1 H), 6.88 (s, 0.6 H), 6.71-6.81 (m, 1 H), 6.48-6.67 (m, 1.4 H), 4.76 (br dd, 0.3 H), 4.51 (br dd, 0.7 H), 3.62-3.71 (m, 0.5 H), 3.22 (td, 0.5 H), 2.90-3.00 (m, 0.5 H), 2.65-2.85 (m, 1.5 H), 2.06-2.44 (m, 4 H), 0.78-1.13 (m, 4 H) 322.1 [M+H] + 99.6%
2025 (CD 3OD) δ 8.23-8.37 (m, 1 H), 7.64 (d, 1 H), 6.92-7.00 (m, 1 H), 6.88 (s, 0.6 H), 6.70-6.79 (m, 1 H), 6.47-6.64 (m, 1.4 H), 4.76 (br dd, 0.3 H), 4.51 (br dd, 0.7 H), 3.66 (ddd, 0.5 H), 3.22 (td, 0.5 H), 2.89-3.01 (m, 0.5 H), 2.64-2.85 (m, 1.5 H), 2.03-2.44 (m, 4 H), 0.76-1.13 (m, 4 H) 322.2 [M+H] + 99.6%
2026 (CD 3OD) δ 8.28 (br d, 1 H), 7.61-7.69 (m, 1 H), 6.88-7.06 (m, 1.8 H), 6.71-6.80 (m, 1 H), 6.47-6.58 (m, 1.2 H), 4.84 (br d, 0.3 H), 4.33 (br dd, 0.7 H), 3.70 (ddd, 0.7 H), 3.35-3.43 (m, 0.3 H), 3.09 (td, 0.8 H), 2.69-2.96 (m, 2.2 H), 2.42 (s, 3 H), 1.99-2.12 (m, 1 H), 1.81 (br dd, 1 H) 358.2 [M+H] + 100%
2027 (CD 3OD) δ 8.23-8.40 (m, 1 H), 7.66 (d, 1 H), 6.96 (br dd, 1 H), 6.68-6.88 (m, 1.5 H), 6.32-6.60 (m, 1.5 H), 4.75 (br dd, 0.5 H), 4.31 (br dd, 0.5 H), 3.65-3.81 (m, 0.5 H), 3.48 (td, 0.5 H), 2.95-3.25 (m, 1.5 H), 2.67-2.87 (m, 1.5 H), 2.41 (s, 3 H), 2.06-2.21 (m, 1 H), 1.70-1.95 (m, 1 H) 358.2 [M+H] + 100%
2028 (CD 3OD) δ 8.25-8.32 (m, 1 H), 7.59-7.71 (m, 1 H), 6.91-7.02 (m, 2 H), 6.76 (t, 1 H), 6.47-6.57 (m, 1 H), 4.83 (br d, 0.2 H), 4.33 (dd, 0.8 H), 3.70 (ddd, 0.8 H), 3.34-3.42 (m, 0.2 H), 3.09 (ddd, 0.8 H), 2.69-2.94 (m, 2.2 H), 2.42 (s, 3 H), 2.05 (dtd, 1 H), 1.76-1.88 (m, 1 H) 358.2 [M+H] + 100%
2029 (CD 3OD) δ 8.24-8.43 (m, 1 H), 7.66 (d, 1 H), 6.97 (br dd, 1 H), 6.68-6.87 (m, 1.5 H), 6.35-6.55 (m, 1.5 H), 4.75 (br dd, 1 H), 4.31 (dd, 0.5 H), 3.66-3.77 (m, 0.5 H), 3.43-3.53 (m, 0.5 H), 3.20 (td, 0.5 H), 2.95-3.14 (m, 1 H), 2.71-2.85 (m, 1 H), 2.41 (s, 3 H), 2.04-2.18 (m, 1 H), 1.74-1.91 (m, 1 H) 358.2 [M+H] + 98.5%
2030 (CD 3OD) δ 8.32 (d, 1 H), 7.66 (s, 1 H), 6.90-7.01 (m, 1.7 H), 6.81 (td, 1 H), 6.50-6.69 (m, 1.3 H), 4.85 (br d, 0.4 H), 4.36 (dd, 0.6 H), 3.69 (ddd, 0.8 H), 3.36-3.41 (m, 0.2 H), 3.04-3.15 (m, 0.8 H), 2.69-2.96 (m, 2.2 H), 1.99-2.11 (m, 1 H), 1.73-1.91 (m, 1 H) 362.2 [M+H] + 100%
2031 (CD 3OD) δ 8.28-8.44 (m, 1 H), 7.67 (d, 1 H), 6.89-7.00 (m, 1 H), 6.39-6.89 (m, 3 H), 4.76 (br dd, 0.7 H), 4.34 (br dd, 0.3 H), 3.66-3.77 (m, 0.5 H), 3.41-3.51 (m, 0.5 H), 3.09-3.22 (m, 1 H), 2.95-3.08 (m, 0.5 H), 2.69-2.88 (m, 1.5 H), 2.06-2.19 (m, 1 H), 1.76-1.96 (m, 1 H) 362.1 [M+H] + 90.8%
2032 (CD 3OD) δ 8.72 (d, 1 H), 7.85-8.47 (m, 4 H), 7.68 (s, 1 H), 7.49-7.61 (m, 1 H), 6.65-7.04 (m, 4 H), 4.61-4.76 (m, 1 H), 3.41-3.90 (m, 1 H), 2.94-3.24 (m, 1 H), 2.70-2.93 (m, 1 H) 430.1 [M+H] + 100%
2033 (CD 3OD) δ 8.71 (dt, 1 H), 7.85-8.50 (m, 4 H), 7.68 (br s, 1 H), 7.57 (dd, 1 H), 6.67-7.02 (m, 4 H), 4.61-4.74 (m, 1 H), 3.38-3.90 (m, 1 H), 2.95-3.25 (m, 1 H), 2.85 (br d, 1 H) 430.1 [M+H] + 99.6%
2034 (CD 3OD) δ 8.50-8.80 (m, 2 H), 7.81-8.36 (m, 3 H), 7.69 (br s, 1 H), 7.53-7.61 (m, 1 H), 7.44 (br d, 1 H), 6.52-7.28 (m, 4 H), 4.62-4.79 (m, 1 H), 3.40-3.88 (m, 1 H), 2.68-3.27 (m, 2 H) 462.2 [M+H] + 100%
2035 (CD 3OD) δ 8.42-8.80 (m, 2 H), 7.87-8.32 (m, 3 H), 7.68 (br s, 1 H), 7.57 (br dd, 1 H), 7.44 (br d, 1 H), 6.69-7.15 (m, 4 H), 4.62-4.78 (m, 1 H), 3.42-3.90 (m, 1 H), 2.74-3.25 (m, 2 H) 462.1 [M+H] + 99.7%
2036 (CD 3OD) δ 8.50-8.86 (m, 2 H), 7.83-8.32 (m, 3 H), 7.46-7.77 (m, 3 H), 6.64-7.16 (m, 3 H), 4.62-4.79 (m, 1 H), 3.43-3.91 (m, 1 H), 2.70-3.25 (m, 2 H) 480.1 [M+H] + 99.9%
2037 (CD 3OD) δ 8.57-8.85 (m, 2 H), 7.88-8.30 (m, 3 H), 7.50-7.72 (m, 3 H), 6.69-7.10 (m, 3 H), 4.62-4.79 (m, 1 H), 3.42-3.88 (m, 1 H), 2.78-3.25 (m, 2 H) 480.2 [M+H] + 99.8%
2038 (CD 3OD) δ 8.58 (d, 1 H), 8.13 (s, 1 H), 7.68 (s, 1 H), 7.42 (br d, 1 H), 6.65-7.14 (m, 4 H), 4.38 (br s, 1 H), 3.69 (br s, 1 H), 2.94-3.15 (m, 1 H), 2.79 (br dd, 1 H), 2.36 (br s, 1 H), 0.90-0.99 (m, 4 H) 425.2 [M+H] + 99.0%
2039 (CD 3OD) δ 8.58 (d, 1 H), 8.13 (s, 1 H), 7.67 (s, 1 H), 7.42 (br d, 1 H), 6.64-7.15 (m, 4 H), 4.37 (br s, 1 H), 3.70 (br s, 1 H), 2.96-3.19 (m, 1 H), 2.79 (br dd, 1 H), 2.09-2.46 (m, 1 H), 0.90-1.00 (m, 4 H) 425.2 [M+H] + 100%
2040 (CD 3OD) δ 8.43 (d, 1 H), 8.13 (s, 1 H), 7.68 (s, 1 H), 7.29 (d, 1 H), 6.42-6.94 (m, 3 H), 4.39 (br s, 1 H), 3.38-3.93 (m, 1 H), 2.95-3.16 (m, 1 H), 2.72-2.87 (m, 1 H), 2.36 (br s, 1 H), 0.89-1.03 (m, 4 H) 409.1 [M+H] + 99.5%
2041 (CD 3OD) δ 8.43 (d, 1 H), 8.13 (s, 1 H), 7.67 (s, 1 H), 7.29 (d, 1 H), 6.35-7.00 (m, 3 H), 4.39 (br s, 1 H), 3.36-3.80 (m, 1 H), 3.05 (br s, 1 H), 2.79 (br dd, 1 H), 2.21-2.47 (m, 1 H), 0.92-1.04 (m, 4 H) 409.2 [M+H] + 99.1%
2042 (CD 3OD) δ 8.03 (s, 1 H), 7.40-7.60 (m, 2 H), 6.43-7.08 (m, 4 H), 4.28 (br s, 1 H), 3.76 (br s, 1 H), 2.89 (br d, 1 H), 2.68 (br dd, 1 H), 2.25 (br s, 1 H), 0.85 (br d, 4 H) 409.2 [M+H] + 99.6%
2043 (CD 3OD) δ 8.03 (s, 1 H), 7.37-7.60 (m, 2 H), 6.47-7.13 (m, 4 H), 4.29 (br s, 1 H), 3.27-3.87 (m, 1 H), 2.82-2.99 (m, 1 H), 2.68 (dd, 1 H), 2.25 (br s, 1 H), 0.86 (br d, 4 H) 409.2 [M+H] + 99.8%
2044 (CD 3OD) δ 8.30-8.38 (m, 1 H), 8.24 (s, 1 H), 7.96 (s, 1 H), 7.72 (s, 0.4 H), 7.55-7.60 (m, 1 H), 7.44-7.51 (m, 1 H), 7.04-7.14 (m, 1 H), 6.83 (s, 0.6 H), 6.75 (br dd, 1 H), 6.43-6.55 (m, 1 H), 5.13 (dd, 0.6 H), 4.80-4.85 (m, 0.4 H), 3.88 (s, 3 H), 3.57-3.68 (m, 0.6 H), 3.32 (td, 0.4 H), 2.84-3.12 (m, 1 H), 2.71 (br d, 1 H) 432.1 [M+H] + 100%
2045 (CD 3OD) δ 8.28-8.39 (m, 1 H), 8.25 (s, 1 H), 7.96 (s, 1 H), 7.68-7.75 (m, 0.4 H), 7.54-7.61 (m, 1 H), 7.41-7.52 (m, 1 H), 7.02-7.14 (m, 1 H), 6.83 (s, 0.6 H), 6.69-6.79 (m, 1 H), 6.42-6.57 (m, 1 H), 5.13 (dd, 0.6 H), 4.80-4.86 (m, 0.4 H), 3.88 (s, 3 H), 3.57-3.68 (m, 0.6 H), 3.26-3.41 (m, 0.4 H), 2.84-3.11 (m, 1 H), 2.71 (br d, 1 H) 432.1 [M+H] + 100%
2046 (CD 3OD) δ 8.12-8.27 (m, 2 H), 7.96 (s, 1 H), 7.72 (s, 0.4 H), 7.52-7.61 (m, 1 H), 6.79-6.93 (m, 1.6 H), 6.59-6.72 (m, 1 H), 6.44-6.54 (m, 1 H), 5.07-5.35 (m, 0.6 H), 4.80-4.86 (m, 0.4 H), 3.88 (s, 3 H), 3.58-3.68 (m, 0.6 H), 3.33 (td, 0.4 H), 2.84-3.13 (m, 1 H), 2.71 (br d, 1 H), 2.28-2.37 (m, 3 H) 446.2 [M+H] + 100%
2047 (CD 3OD) δ 8.11-8.28 (m, 2 H), 7.96 (s, 1 H), 7.72 (s, 0.4 H), 7.52-7.62 (m, 1 H), 6.78-6.92 (m, 1.6 H), 6.60-6.73 (m, 1 H), 6.44-6.55 (m, 1 H), 5.08-5.35 (m, 0.6 H), 4.80-4.87 (m, 0.4 H), 3.88 (s, 3 H), 3.57-3.68 (m, 0.6 H), 3.28-3.38 (m, 0.4 H), 2.83-3.12 (m, 1 H), 2.62-2.77 (m, 1 H), 2.28-2.36 (m, 3 H) 446.2 [M+H] + 99.2%
2048 (CD 3OD) δ 8.25-8.47 (m, 1 H), 7.76 (d, 1 H), 7.56-7.69 (m, 2.4 H), 7.42-7.53 (m, 2 H), 7.36-7.42 (m, 1 H), 7.00-7.16 (m, 1 H), 6.89 (s, 0.6 H), 6.67-6.82 (m, 1 H), 6.40-6.58 (m, 1 H), 4.85-4.92 (m, 1 H), 3.58-3.75 (m, 0.5 H), 3.23-3.37 (m, 0.5 H), 2.85-3.17 (m, 1 H), 2.73 (br dd, 1 H) 385.1 [M+H] + 98.2%
2049 (CD 3OD) δ 8.20-8.44 (m, 1 H), 7.76 (d, 1 H), 7.55-7.69 (m, 2.3 H), 7.42-7.52 (m, 2 H), 7.35-7.42 (m, 1 H), 7.03-7.17 (m, 1 H), 6.90 (s, 0.7 H), 6.67-6.83 (m, 1 H), 6.39-6.60 (m, 1 H), 4.88 (br dd, 1 H), 3.59-3.74 (m, 0.6 H), 3.25-3.35 (m, 0.4 H), 2.87-3.16 (m, 1 H), 2.74 (br dd, 1 H) 385.2 [M+H] + 97.7%
2050 (CD 3OD) δ 8.25-8.42 (m, 1 H), 7.84-7.91 (m, 1 H), 7.65-7.83 (m, 2.4 H), 7.45-7.62 (m, 2 H), 6.92-7.04 (m, 1.6 H), 6.81-6.91 (m, 1 H), 6.67-6.81 (m, 1 H), 4.98-5.06 (m, 1 H), 3.70-3.89 (m, 0.7 H), 3.41 (td, 0.3 H), 2.98-3.28 (m, 1 H), 2.85 (br dd, 1 H) 403.1 [M+H] + 100%
2051 (CD 3OD) δ 8.27-8.45 (m, 1 H), 7.86-7.95 (m, 1 H), 7.71-7.84 (m, 2.3 H), 7.47-7.66 (m, 2 H), 6.93-7.08 (m, 1.7 H), 6.83-6.91 (m, 1 H), 6.70-6.82 (m, 1 H), 4.99-5.09 (m, 1 H), 3.73-3.87 (m, 0.6 H), 3.38-3.48 (m, 0.4 H), 3.00-3.31 (m, 1 H), 2.88 (dd, 1 H) 403.2 [M+H] + 99.2%
2052 (DMSO- d 6) δ 11.98-12.19 (m, 1 H), 8.66-8.95 (m, 1 H), 7.81-8.06 (m, 2 H), 7.61-7.71 (m, 1 H), 7.56-7.61 (m, 1 H), 7.47-7.55 (m, 2 H), 7.08-7.45 (m, 1 H), 6.88-7.05 (m, 1 H), 6.58-6.83 (m, 2 H), 4.84 (br dd, 1 H), 3.55-3.80 (m, 0.6 H), 3.15-3.30 (m, 0.4 H), 2.85-3.11 (m, 1 H), 2.65-2.83 (m, 1 H) 435.2 [M+H] + 99.2%
2053 (DMSO- d 6) δ 11.86-12.54 (m, 1 H), 8.57-9.00 (m, 1 H), 7.84-7.99 (m, 2 H), 7.63-7.70 (m, 1 H), 7.55-7.62 (m, 1 H), 7.46-7.54 (m, 2.3 H), 7.46 (br s, 1 H), 6.89-7.03 (m, 1 H), 6.62-6.86 (m, 1.7 H), 4.84 (br dd, 1 H), 3.64-3.75 (m, 0.5 H), 3.20-3.27 (m, 0.5 H), 2.84-3.12 (m, 1 H), 2.77 (br d, 1 H) 435.2 [M+H] + 98.8%
2054 (DMSO- d 6) δ 11.83-12.41 (m, 1 H), 8.74-9.12 (m, 1 H), 7.83-8.06 (m, 2 H), 7.69-7.82 (m, 1 H), 7.62-7.68 (m, 1 H), 7.46-7.61 (m, 2.5 H), 6.93-7.09 (m, 1 H), 6.57-6.85 (m, 1.5 H), 4.86 (br dd, 1 H), 3.59-3.83 (m, 0.6 H), 3.16-3.28 (m, 0.4 H), 2.85-3.11 (m, 1 H), 2.71-2.83 (m, 1 H) 453.1 [M+H] + 99.4%
2055 (DMSO- d 6) δ 11.98-12.28 (m, 1 H), 8.81-9.08 (m, 1 H), 7.81-8.03 (m, 2 H), 7.69-7.79 (m, 1 H), 7.62-7.69 (m, 1 H), 7.45-7.61 (m, 2.5 H), 6.95-7.10 (m, 1 H), 6.58-6.85 (m, 1.5 H), 4.86 (br dd, 1 H), 3.63-3.79 (m, 0.6 H), 3.20-3.30 (m, 0.4 H), 2.84-3.11 (m, 1 H), 2.72-2.83 (m, 1 H) 453.2 [M+H] + 99.0%
2056 (CD 3OD) δ 8.28 (d, 1 H), 7.70 (s, 1 H), 6.69-6.86 (m, 3 H), 6.42 (s, 1 H), 4.35 (dd, 1 H), 3.73-3.87 (m, 1 H), 3.00-3.16 (m, 1 H), 2.85 (dd, 1 H), 2.00-2.17 (m, 1 H), 0.93-1.09 (m, 2 H), 0.67-0.84 (m, 2 H) 416.2 [M+H] + 99.5%
2057 (CD 3OD) δ 8.29 (d, 1 H), 7.70 (s, 1 H), 6.72-6.89 (m, 3 H), 6.41 (s, 1 H), 4.35 (dd, 1 H), 3.73-3.87 (m, 1 H), 3.01-3.16 (m, 1 H), 2.85 (dd, 1 H), 2.02-2.16 (m, 1 H), 0.96-1.09 (m, 2 H), 0.71-0.85 (m, 2 H) 416.2 [M+H] + 99.8%
2058 (CD 3OD) δ 8.28 (d, 1 H), 7.67 (s, 1 H), 6.65-6.87 (m, 3 H), 6.27 (s, 1 H), 4.19 (dd, 1 H), 3.62-3.79 (m, 1 H), 2.93-3.10 (m, 1 H), 2.80 (dd, 1 H), 2.00-2.18 (m, 2 H), 1.01-1.14 (m, 6 H), 0.75-0.82 (m, 2 H) 388.2 [M+H] + 99.8%
2059 (CD 3OD) δ 8.28 (d, 1 H), 7.67 (s, 1 H), 6.64-6.86 (m, 3 H), 6.27 (s, 1 H), 4.19 (dd, 1 H), 3.62-3.75 (m, 1 H), 2.94-3.10 (m, 1 H), 2.80 (dd, 1 H), 2.03-2.15 (m, 2 H), 0.98-1.14 (m, 6 H), 0.71-0.82 (m, 2 H) 388.2 [M+H] + 99.7%
2060 (CD 3OD) δ 8.16-8.34 (m, 1 H), 7.70 (s, 1 H), 7.42 (s, 0.3 H), 6.95 (s, 0.7 H), , 6.60-6.85 (m, 3 H), 4.97 (br d, 1 H), 3.76 (ddd, 0.7 H), 3.40 (td, 0.3 H), 3.08-3.23 (m, 0.7 H), 2.94-3.04 (m, 0.3 H), 2.84 (br dd, 1 H), 2.02-2.15 (m, 1 H), 1.80-1.97 (m, 6 H), 0.92-1.11 (m, 2 H), 0.71-0.83 (m, 2 H) 436.2 [M+H] + 99.9%
2061 (CD 3OD) δ 8.15-8.35 (m, 1 H), 7.70 (s, 1 H), 7.42 (s, 0.3 H), 6.95 (s, 0.7 H), 6.66-6.87 (m, 3 H), 4.95-5.01 (m, 1 H), 3.70-3.84 (m, 0.7 H), 3.35-3.44 (m, 0.3 H), 3.10-3.22 (m, 0.7 H), 2.93-3.05 (m, 0.3 H), 2.78-2.89 (m, 1 H), 2.03-2.15 (m, 1 H), 1.80-1.97 (m, 6 H), 0.96-1.09 (m, 2 H), 0.73-0.83 (m, 2 H) 436.2 [M+H] + 99.1%
2062 (CD 3OD) δ 8.44 (d, 1 H), 7.54-7.79 (m, 2 H), 7.15-7.38 (m, 3 H), 6.69-6.93 (m, 2 H), 6.42 (s, 1 H), 4.38 (dd, 1 H), 3.80 (ddd, 1 H), 3.00-3.20 (m, 1 H), 2.86 (dd, 1 H) 454.1 [M+H] + 100%
2063 (CD 3OD) δ 8.32 (d, 1 H), 7.42-7.68 (m, 2 H), 7.00-7.24 (m, 3 H), 6.53-6.82 (m, 2 H), 6.30 (s, 1 H), 4.26 (dd, 1 H), 3.68 (ddd, 1 H), 2.90-3.06 (m, 1 H), 2.73 (dd, 1 H) 454.1 [M+H] + 96.6%
2064 (CD 3OD) δ 8.37 (br s, 1 H), 8.01 (br s, 0.5 H), 7.64-7.84 (m, 1.5 H), 6.99 (br t, 1 H), 6.87 (br s, 1.6 H), 6.57-6.81 (m, 1.4 H), 4.73-4.83 (m, 0.4 H), 4.49 (br s, 0.6 H), 3.78 (br s, 0.6 H), 3.36-3.46 (m, 0.4 H), 3.12 (br s, 1 H), 2.84 (br s, 1 H), 1.73-1.95 (m, 6 H) 413.2 [M+H] + 100%
2065 (CD 3OD) δ 8.36 (br s, 1 H), 8.01 (br s, 0.4 H), 7.62-7.88 (m, 1.6 H), 6.93-7.05 (m, 1 H), 6.86 (br s, 1.5 H), 6.52-6.80 (m, 1.5 H), 4.69-4.81 (m, 0.4 H), 4.46 (br s, 0.6 H), 3.78 (br s, 0.6 H), 3.37 (br s, 0.4 H), 2.94-3.19 (m, 1 H), 2.83 (br s, 1 H), 1.84 (br d, 6 H) 413.2 [M+H] + 100%
2066 (CD 3OD) δ 8.38 (br s, 1 H), 7.74-8.15 (m, 2 H), 7.70 (s, 1 H), 6.94-7.07 (m, 1 H), 6.59-6.93 (m, 3 H), 4.66-4.87 (m, 1 H), 3.86 (br s, 3 H), 3.50 (s, 1 H), 2.78-3.23 (m, 2 H), 2.44-2.77 (m, 3 H) 447.2 [M+H] + 100%
2067 (CD 3OD) δ 8.39 (br s, 1 H), 7.75-8.16 (m, 2 H), 7.70 (s, 1 H), 6.99 (br t, 1 H), 6.57-6.94 (m, 3 H), 4.65-4.84 (m, 1 H), 3.86 (br s, 3 H), 3.50 (s, 1 H), 2.79-3.26 (m, 2 H), 2.66 (br s, 3 H) 447.2 [M+H] + 100%
2068 (CD 3OD) δ 8.62 (br s, 1 H), 7.76-8.15 (m, 2 H), 7.70 (s, 1 H), 7.46 (br d, 1 H), 6.63-7.18 (m, 4 H), 4.65-4.84 (m, 1 H), 3.86 (br s, 3 H), 3.38-3.82 (m, 1 H), 2.78-3.24 (m, 2 H), 2.42-2.76 (m, 3 H) 479.2 [M+H] + 99.7%
2069 (CD 3OD) δ 8.62 (br s, 1 H), 7.75-8.13 (m, 2 H), 7.70 (s, 1 H), 7.45 (br d, 1 H), 6.67-7.18 (m, 4 H), 4.82 (br s, 1 H), 3.86 (br s, 3 H), 3.37-3.82 (m, 1 H), 2.79-3.25 (m, 2 H), 2.43-2.78 (m, 3 H) 479.2 [M+H] + 98.9%
2070 (CD 3OD) δ 8.16 (s, 1 H), 7.43-7.68 (m, 2 H), 6.47-7.17 (m, 4 H), 4.38 (br s, 1 H), 3.58-3.99 (m, 1 H), 2.78-3.11 (m, 2 H), 2.66 (s, 3 H), 2.32 (br s, 1 H), 0.97 (br d, 4 H) 389.2 [M+H] + 100%
2071 (CD 3OD) δ 8.16 (s, 1 H), 7.39-7.76 (m, 2 H), 6.22-7.18 (m, 4 H), 4.39 (br s, 1 H), 3.53-4.00 (m, 1 H), 2.76-3.14 (m, 2 H), 2.66 (s, 3 H), 2.32 (br s, 1 H), 0.97 (br d, 4 H) 389.2 [M+H] + 95.0%
2072 (CD 3OD) δ 8.24 (br d, 1 H), 7.66-8.14 (m, 2 H), 7.57 (s, 1 H), 6.50-6.90 (m, 4 H), 4.37-4.63 (m, 1 H), 3.83 (s, 3 H), 3.51-3.73 (m, 0.7 H), 3.27-3.46 (m, 0.3 H), 2.86-3.11 (m, 1 H), 2.72 (br d, 1 H), 2.25-2.37 (m, 1 H), 0.80-0.95 (m, 4 H) 473.2 [M+H] + 99.0%
2073 (CD 3OD) δ 8.23 (br s, 1 H), 7.65-8.14 (m, 2 H), 7.57 (s, 1 H), 6.48-6.91 (m, 4 H), 4.37-4.64 (m, 1 H), 3.82 (br s, 3 H), 3.49-3.71 (m, 0.7 H), 3.26-3.42 (m, 0.3 H), 2.88-3.08 (m, 1 H), 2.71 (br d, 1 H), 2.31 (quin, 1 H), 0.78-0.95 (m, 4 H) 473.2 [M+H] + 98.8%
2074 (CD 3OD) δ 8.33 (br d, 1 H), 7.78-8.25 (m, 2 H), 7.69 (s, 1 H), 6.50-7.06 (m, 4 H), 4.48-4.76 (m, 1 H), 3.94 (br s, 3 H), 3.65-3.84 (m, 0.6 H), 3.41-3.59 (m, 0.4 H), 3.00-3.20 (m, 1 H), 2.73-2.93 (m, 1 H), 2.38-2.54 (m, 4 H), 0.86-1.14 (m, 4 H) 469.2 [M+H] + 99.5%
2075 (CD 3OD) δ 8.15-8.31 (m, 1 H), 7.68-8.13 (m, 2 H), 7.57 (s, 1 H), 6.41-6.90 (m, 4 H), 4.42-4.70 (m, 1 H), 3.81 (br s, 3 H), 3.51-3.71 (m, 0.6 H), 3.25-3.38 (m, 0.4 H), 2.86-3.10 (m, 1 H), 2.60-2.81 (m, 1 H), 2.26-2.38 (m, 4 H), 0.80-0.94 (m, 4 H) 469.2 [M+H] + 99.5%
2076 (CD 3OD) δ 8.47-8.63 (m, 1 H), 8.10 (s, 1 H), 7.65-7.77 (m, 1 H), 7.34-7.49 (m, 2 H), 6.67-7.15 (m, 4 H), 5.07 (dd, 1 H), 3.68 (ddd, 0.7 H), 3.33-3.38 (m, 0.3 H), 3.06-3.19 (m, 0.7 H), 2.89-3.01 (m, 0.3 H), 2.79 (dd, 1 H) 385.1 [M+H] + 100%
2077 (CD 3OD) δ 8.50-8.60 (m, 1 H), 8.10 (s, 1 H), 7.64-7.78 (m, 1 H), 7.33-7.49 (m, 2 H), 6.68-7.16 (m, 4 H), 5.08 (dd, 1 H), 3.68 (ddd, 0.7 H), 3.33-3.38 (m, 0.3 H), 3.07-3.19 (m, 0.7 H), 2.91-3.01 (m, 0.3 H), 2.79 (dd, 1 H) 385.1 [M+H] + 98.1%
2078 (CD 3OD) δ 8.61-8.73 (m, 1 H), 8.11 (s, 1 H), 7.68-7.79 (m, 1 H), 7.56-7.65 (m, 1 H), 7.34-7.46 (m, 1 H), 6.92-7.04 (m, 2 H), 6.64-6.82 (m, 1 H), 5.10 (dd, 1 H), 3.68 (ddd, 0.7 H), 3.33-3.38 (m, 0.3 H), 3.09-3.19 (m, 0.7 H), 2.91-3.01 (m, 0.3 H), 2.79 (dd, 1 H) 403.1 [M+H] + 99.9%
2079 (CD 3OD) δ 8.62-8.73 (m, 1 H), 8.11 (s, 1 H), 7.67-7.78 (m, 1 H), 7.55-7.66 (m, 1 H), 7.35-7.46 (m, 1 H), 6.90-7.04 (m, 2 H), 6.64-6.80 (m, 1 H), 5.10 (dd, 1 H), 3.68 (ddd, 0.6 H), 3.33-3.38 (m, 0.4 H), 3.09-3.19 (m, 0.7 H), 2.92-3.01 (m, 0.3 H), 2.79 (dd, 1 H) 403.1 [M+H] + 98.8%
2080 (CD 3OD) δ 8.27-8.42 (m, 1 H), 7.60-7.68 (m, 1 H), 6.74-6.99 (m, 2.7 H), 6.50-6.68 (m, 1 H), 6.11 (s, 0.3 H), 4.78 (br dd, 0.3 H), 4.01 (br dd, 0.7 H), 3.85 (t, 0.3 H), 3.45-3.62 (m, 1.4 H), 3.12 (td, 0.3 H), 2.47-2.86 (m, 2 H), 1.80-2.42 (m, 6 H) 340.2 [M+H] + 99.7%
2081 (CD 3OD) δ 8.27-8.41 (m, 1 H), 7.61-7.67 (m, 1 H), 6.89-6.99 (m, 1 H), 6.74-6.87 (m, 1.7 H), 6.51-6.65 (m, 1 H), 6.11 (s, 0.3 H), 4.78 (br dd, 0.3 H), 4.02 (dd, 0.7 H), 3.86 (quin, 0.3 H), 3.47-3.60 (m, 1.4 H), 3.07-3.17 (m, 0.3 H), 2.47-2.86 (m, 2 H), 1.80-2.42 (m, 6 H) 340.2 [M+H] + 99.5%
2082 (CD 3OD) δ 8.18 (d, 1 H), 7.55 (s, 1 H), 6.94 (d, 1 H), 6.72 (t, 1 H), 6.49 (s, 1 H), 6.18 (s, 1 H), 4.10 (dd, 1 H), 3.59 (ddd, 1 H), 2.86-3.12 (m, 2 H), 2.67 (dd, 1 H), 2.32 (s, 3 H), 1.22 (dd, 6 H) 364.2 [M+H] + 99.3%
2083 (CD 3OD) δ 8.18 (d, 1 H), 7.55 (s, 1 H), 6.93 (d, 1 H), 6.61-6.78 (m, 1 H), 6.49 (s, 1 H), 6.18 (s, 1 H), 4.10 (dd, 1 H), 3.59 (ddd, 1 H), 2.87-3.12 (m, 2 H), 2.67 (dd, 1 H), 2.32 (s, 3 H), 1.17-1.25 (m, 6 H) 364.2 [M+H] + 99.3%
2084 (CD 3OD) δ 8.31 (d, 1 H), 7.69 (s, 1 H), 6.83-7.15 (m, 3 H), 6.66 (s, 1 H), 6.39 (s, 1 H), 4.33 (dd, 1 H), 3.79 (ddd, 1 H), 3.03-3.25 (m, 2 H), 2.84 (dd, 1 H), 1.35 (dd, 6 H) 400.2 [M+H] + 99.9%
2085 (CD 3OD) δ 8.31 (d, 1 H), 7.69 (s, 1 H), 6.83-7.15 (m, 3 H), 6.62-6.70 (m, 1 H), 6.39 (s, 1 H), 4.33 (dd, 1 H), 3.73-3.86 (m, 1 H), 3.02-3.24 (m, 2 H), 2.84 (dd, 1 H), 1.35 (dd, 6 H) 400.2 [M+H] + 99.8%
2086 (CD 3OD) δ 8.03 (dd, 2 H), 7.68 (s, 1 H), 7.59 (dd, 1 H), 7.28 (t, 2 H), 7.17 (dd, 1 H), 7.03 (dd, 1 H), 6.71 (s, 1 H), 6.47 (s, 1 H), 4.38 (dd, 1 H), 3.76-3.91 (m, 1 H), 3.02-3.17 (m, 1 H), 2.87 (dd, 1 H) 436.1 [M+H] + 100%
2087 (CD 3OD) δ 8.03 (dd, 2 H), 7.68 (s, 1 H), 7.60 (d, 1 H), 7.29 (t, 2 H), 7.17 (dd, 1 H), 7.03 (d, 1 H), 6.71 (s, 1 H), 6.47 (s, 1 H), 4.38 (dd, 1 H), 3.77-3.91 (m, 1 H), 3.04-3.16 (m, 1 H), 2.79-2.94 (m, 1 H) 436.1 [M+H] + 99.3%
2088 (CD 3OD) δ 7.59-7.69 (m, 3 H), 7.15-7.26 (m, 3 H), 7.04 (dd, 1 H), 6.74 (s, 1 H), 6.43 (s, 1 H), 4.38 (dd, 1 H), 3.87 (ddd, 1 H), 3.01-3.19 (m, 1 H), 2.86 (dd, 1 H) 454.1 [M+H] + 100%
2089 (CD 3OD) δ 7.57-7.71 (m, 3 H), 7.14-7.26 (m, 3 H), 7.03 (dd, 1 H), 6.73 (s, 1 H), 6.43 (s, 1 H), 4.38 (dd, 1 H), 3.87 (ddd, 1 H), 3.01-3.18 (m, 1 H), 2.86 (dd, 1 H) 454.1 [M+H] + 98.4%
2090 (CD 3OD) δ 7.46-7.59 (m, 2 H), 7.35 (d, 1 H), 6.96-7.13 (m, 3 H), 6.59 (d, 1 H), 6.25-6.47 (m, 2 H), 4.24 (dd, 1 H), 3.72 (ddd, 1 H), 2.88-3.05 (m, 1 H), 2.73 (dd, 1 H), 2.51 (s, 3 H) 434.2 [M+H] + 100%
2091 (CD 3OD) δ 7.57-7.69 (m, 2 H), 7.47 (d, 1 H), 7.08-7.25 (m, 3 H), 6.71 (d, 1 H), 6.38-6.56 (m, 2 H), 4.36 (dd, 1 H), 3.84 (ddd, 1 H), 3.01-3.16 (m, 1 H), 2.85 (dd, 1 H), 2.63 (s, 3 H) 434.2 [M+H] + 100%
2092 (CD 3OD) δ 7.75 (d, 1 H), 7.58-7.71 (m, 2 H), 7.50 (s, 0.3 H), 7.36 (s, 0.5 H), 7.17-7.31 (m, 4.2 H), 6.70 (s, 1 H), 6.42 (br s, 1 H), 4.38 (dd, 1 H), 3.78-3.91 (m, 1 H), 3.01-3.18 (m, 1 H), 2.86 (br dd, 1 H) 470.2 [M+H] + 100%
2093 (CD 3OD) δ 7.74 (d, 1 H), 7.58-7.71 (m, 2 H), 7.49 (s, 0.3 H), 7.36 (s, 0.5 H), 7.16-7.31 (m, 4.2 H), 6.70 (s, 1 H), 6.42 (s, 1 H), 4.38 (dd, 1 H), 3.75-3.94 (m, 1 H), 3.01-3.18 (m, 1 H), 2.86 (dd, 1 H) 470.2 [M+H] + 100%
2094 (CD 3OD) δ 8.26-8.35 (m, 2 H), 7.65 (dd, 1 H), 7.53 (s, 1 H), 7.15 (d, 1 H), 7.02 (d, 1 H), 6.80 (s, 1 H), 6.70 (t, 1 H), 6.53 (s, 1 H), 4.61 (br dd, 1 H), 3.40-3.56 (m, 1 H), 2.76-2.91 (m, 1 H), 2.62 (br dd, 1 H) 419.1 [M+H] + 99.5%
2095 (CD 3OD) δ 8.44 (br d, 2 H), 7.78 (dd, 1 H), 7.66 (s, 1 H), 7.28 (d, 1 H), 7.15 (d, 1 H), 6.92 (s, 1 H), 6.82 (t, 1 H), 6.65 (s, 1 H), 4.73 (br dd, 1 H), 3.53-3.66 (m, 1 H), 2.89-3.03 (m, 1 H), 2.75 (br dd, 1 H) 419.1 [M+H] + 98.6%
2096 (CD 3OD) δ 8.39 (s, 1 H), 7.76 (dd, 1 H), 7.62 (s, 1 H), 7.44 (d, 1 H), 7.20 (d, 1 H), 7.10 (dd, 1 H), 6.80 (s, 1 H), 6.69 (d, 1 H), 6.48 (s, 1 H), 4.83 (br dd, 1 H), 3.60-3.73 (m, 1 H), 2.88-3.01 (m, 1 H), 2.74 (dd, 1 H), 2.69 (s, 3 H) 399.2 [M+H] + 97.4%
2097 (CD 3OD) δ 8.28 (s, 1 H), 7.64 (dd, 1 H), 7.50 (s, 1 H), 7.33 (d, 1 H), 7.09 (d, 1 H), 6.98 (dd, 1 H), 6.68 (s, 1 H), 6.58 (d, 1 H), 6.36 (s, 1 H), 4.72 (br dd, 1 H), 3.50-3.62 (m, 1 H), 2.77-2.89 (m, 1 H), 2.62 (dd, 1 H), 2.57 (s, 3 H) 399.2 [M+H] + 96.1%
2098 (CD 3OD) δ 8.20-8.54 (m, 1 H), 7.54-7.99 (m, 2 H), 6.91-7.05 (m, 1 H), 6.46-6.89 (m, 3 H), 4.34-4.81 (m, 1 H), 3.42-3.93 (m, 1 H), 2.69-3.21 (m, 2 H), 2.18 (br d, 1 H), 1.14 (br s, 4 H) 393.2 [M+H] + 99.4%
2099 (CD 3OD) δ 8.20-8.54 (m, 1 H), 7.67 (s, 2 H), 6.91-7.07 (m, 1 H), 6.39-6.90 (m, 3 H), 4.42-4.79 (m, 1 H), 3.38-4.00 (m, 1 H), 2.61-3.15 (m, 2 H), 2.18 (br d, 1 H), 1.14 (br s, 4 H) 393.2 [M+H] + 98.4%
2100 (CD 3OD) δ 8.36 (br s, 1 H), 7.58-8.04 (m, 2 H), 6.55-7.10 (m, 4 H), 4.58-4.84 (m, 1 H), 3.35-3.87 (m, 1 H), 2.68-3.21 (m, 2 H), 1.26-1.55 (m, 9 H) 409.2 [M+H] + 100%
2101 (CD 3OD) δ 8.23 (br s, 1 H), 7.37-7.93 (m, 2 H), 6.38-7.02 (m, 4 H), 4.46-4.74 (m, 1 H), 3.24-3.81 (m, 1 H), 2.53-3.10 (m, 2 H), 1.08-1.49 (m, 9 H) 409.2 [M+H] + 99.6%
2102 (CD 3OD) δ 8.58 (br d, 1 H), 7.50-7.95 (m, 2 H), 7.43 (br d, 1 H), 6.48-7.17 (m, 4 H), 4.38-4.83 (m, 1 H), 3.34-3.88 (m, 1 H), 2.69-3.12 (m, 2 H), 2.18 (br s, 1 H), 1.14 (br s, 4 H) 425.2 [M+H] + 100%
2103 (CD 3OD) δ 8.41-8.77 (m, 1 H), 7.55-7.99 (m, 2 H), 7.43 (br d, 1 H), 6.39-7.20 (m, 4 H), 4.40-4.82 (m, 1 H), 3.43-3.88 (m, 1 H), 2.67-3.12 (m, 2 H), 2.18 (br d, 1 H), 1.14 (br s, 4 H) 425.2 [M+H] + 99.2%
2104 (CD 3OD) δ 8.48-8.75 (m, 1 H), 7.34-8.01 (m, 3 H), 6.57-7.20 (m, 4 H), 4.60-4.85 (m, 1 H), 3.34-3.86 (m, 1 H), 2.68-3.20 (m, 2 H), 1.25-1.60 (m, 9 H) 441.2 [M+H] + 100%
2105 (CD 3OD) δ 8.60 (br d, 1 H), 7.57-8.02 (m, 2 H), 7.45 (br d, 1 H), 6.58-7.18 (m, 4 H), 4.62-4.84 (m, 1 H), 3.34-3.88 (m, 1 H), 2.68-3.25 (m, 2 H), 1.25-1.58 (m, 9 H) 441.2 [M+H] + 99.5%
2106 (CD 3OD) δ 8.42-8.92 (m, 1 H), 8.02 (br s, 0.4 H), 7.65-7.86 (m, 1.6 H), 7.46 (br d, 1 H), 7.14 (s, 0.2 H), 6.55-7.05 (m, 3.8 H), 4.73-4.83 (m, 0.3 H), 4.47 (br s, 0.7 H), 3.77 (br s, 0.6 H), 3.38-3.47 (m, 0.4 H), 2.96-3.22 (m, 1 H), 2.85 (br s, 1 H), 1.70-1.95 (m, 6 H) 445.2 [M+H] + 100%
2107 (CD 3OD) δ 8.48-8.79 (m, 1 H), 8.01 (br s, 0.4 H), 7.70 (br s, 1.6 H), 7.46 (br d, 1 H), 7.13 (s, 0.2 H), 6.58-7.07 (m, 3.8 H), 4.82 (br s, 0.5 H), 4.47 (br s, 0.5 H), 3.77 (br s, 0.6 H), 3.38-3.47 (m, 0.4 H), 2.94-3.21 (m, 1 H), 2.86 (br d, 1 H), 1.69-1.99 (m, 6 H) 445.2 [M+H] + 99.1%
2108 (CD 3OD) δ 8.70 (br s, 1 H), 7.58-8.11 (m, 4 H), 6.71-7.04 (m, 4 H), 4.67-4.83 (m, 1 H), 3.99 (s, 3 H), 3.39-3.86 (m, 1 H), 2.78-3.23 (m, 2 H) 483.1 [M+H] + 100%
2109 (CD 3OD) δ 8.70 (br s, 1 H), 7.59-8.08 (m, 4 H), 6.77-7.05 (m, 4 H), 4.69-4.83 (m, 1 H), 3.99 (s, 3 H), 3.44-3.89 (m, 1 H), 2.81-3.24 (m, 2 H) 483.2 [M+H] + 98.5%
2110 (CD 3OD) δ 8.74 (br s, 1 H), 7.97 (br s, 2 H), 7.57-7.75 (m, 2 H), 6.61-7.12 (m, 3 H), 4.64-4.85 (m, 1 H), 3.87 (br s, 3 H), 3.35-3.81 (m, 1 H), 2.79-3.23 (m, 2 H), 2.67 (br s, 3 H) 497.2 [M+H] + 99.8%
2111 (CD 3OD) δ 8.60 (br s, 1 H), 7.63-8.03 (m, 2 H), 7.44-7.62 (m, 2 H), 6.51-6.95 (m, 3 H), 4.52-4.73 (m, 1 H), 3.69-3.82 (m, 3 H), 3.26-3.66 (m, 1 H), 2.62-3.12 (m, 2 H), 2.31-2.61 (m, 3 H) 497.2 [M+H] + 99.5%
2112 (CD 3OD) δ 8.13 (s, 1 H), 7.62-7.76 (m, 2 H), 7.34-7.56 (m, 1 H), 7.15-7.29 (m, 2 H), 6.47-6.95 (m, 2 H), 4.37 (br s, 1 H), 3.83 (br s, 1 H), 3.01 (br s, 1 H), 2.78 (dd, 1 H), 2.30 (br d, 1 H), 0.96 (br d, 4 H) 425.2 [M+H] + 100%
2113 (CD 3OD) δ 8.14 (s, 1 H), 7.62-7.77 (m, 2 H), 7.34-7.56 (m, 1 H), 7.13-7.31 (m, 2 H), 6.45-6.95 (m, 2 H), 4.39 (br s, 1 H), 3.56-3.98 (m, 1 H), 3.01 (br s, 1 H), 2.78 (dd, 1 H), 2.31 (br s, 1 H), 0.96 (br d, 4 H) 425.2 [M+H] + 100%
2114 (CD 3OD) δ 8.60 (br d, 1 H), 7.86-8.45 (m, 2 H), 7.74 (s, 1 H), 7.43 (br d, 1 H), 7.14 (s, 0.3 H), 6.70-7.03 (m, 3.7 H), 4.45-4.86 (m, 1 H), 3.86-4.07 (m, 3 H), 3.39-3.83 (m, 1 H), 2.99-3.22 (m, 1 H), 2.84 (br d, 1 H), 2.35-2.52 (m, 1 H), 0.88-1.10 (m, 4 H) 505.2 [M+H] + 99.6%
2115 (CD 3OD) δ 8.59 (br d, 1 H), 7.88-8.43 (m, 2 H), 7.81 (br s, 1 H), 7.42 (br d, 1 H), 7.13 (s, 0.3 H), 6.76-7.02 (m, 3.7 H), 4.41-4.81 (m, 1 H), 3.93 (br s, 3 H), 3.39-3.81 (m, 1 H), 2.99-3.22 (m, 1 H), 2.72-2.93 (m, 1 H), 2.36-2.50 (m, 1 H), 0.91-1.07 (m, 4 H) 505.2 [M+H] + 99.4%
2116 (CD 3OD) δ 8.72 (br d, 1 H), 7.78-8.30 (m, 2 H), 7.70 (s, 1 H), 7.63 (br d, 1 H), 6.99 (t, 1 H), 6.70-6.94 (m, 2 H), 4.43-4.77 (m, 1 H), 3.94 (br s, 3 H), 3.40-3.84 (m, 1 H), 2.99-3.23 (m, 1 H), 2.75-2.92 (m, 1 H), 2.38-2.50 (m, 1 H), 0.94-1.06 (m, 4 H) 523.2 [M+H] + 99.3%
2117 (CD 3OD) δ 8.71 (br d, 1 H), 7.77-8.34 (m, 2 H), 7.70 (s, 1 H), 7.63 (br d, 1 H), 6.98 (t, 1 H), 6.72-6.94 (m, 2 H), 4.44-4.79 (m, 1 H), 3.87-4.00 (m, 3 H), 3.38-3.82 (m, 1 H), 2.97-3.23 (m, 1 H), 2.84 (br d, 1 H), 2.33-2.52 (m, 1 H), 0.91-1.08 (m, 4 H) 523.2 [M+H] + 99.1%
2118 (CD 3OD) δ 8.68 (d, 1 H), 8.35 (d, 1 H), 7.85-8.22 (m, 2 H), 7.45-7.76 (m, 2 H), 6.59-7.28 (m, 4 H), 4.44-4.81 (m, 1 H), 3.45-3.89 (m, 1 H), 2.96-3.28 (m, 1 H), 2.83 (br d, 1 H), 2.33-2.57 (m, 1 H), 0.94-1.16 (m, 4 H) 470.2 [M+H] + 100%
2119 (CD 3OD) δ 8.68 (d, 1 H), 8.35 (d, 1 H), 7.83-8.25 (m, 2 H), 7.44-7.75 (m, 2 H), 6.62-7.25 (m, 4 H), 4.30-4.60 (m, 1 H), 3.46-3.87 (m, 1 H), 2.94-3.28 (m, 1 H), 2.83 (br d, 1 H), 2.43 (br s, 1 H), 0.97-1.19 (m, 4 H) 470.2 [M+H] + 99.7%
2120 (CD 3OD) δ 8.67 (d, 1 H), 8.31 (d, 1 H), 7.83-8.21 (m, 2 H), 7.44-7.72 (m, 2 H), 6.55-7.06 (m, 4 H), 4.39-4.59 (m, 1 H), 3.50-3.90 (m, 1 H), 2.94-3.26 (m, 1 H), 2.73-2.90 (m, 1 H), 2.46 (s, 4 H), 0.93-1.19 (m, 4 H) 466.2 [M+H] + 100%
2121 (CD 3OD) δ 8.67 (d, 1 H), 8.31 (d, 1 H), 7.84-8.19 (m, 2 H), 7.38-7.73 (m, 2 H), 6.43-7.05 (m, 4 H), 4.42-4.58 (m, 1 H), 3.48-3.91 (m, 1 H), 2.95-3.26 (m, 1 H), 2.75-2.90 (m, 1 H), 2.46 (s, 4 H), 0.90-1.20 (m, 4 H) 466.2 [M+H] + 99.7%
2122 (CD 3OD) δ 8.68 (d, 1 H), 8.59 (br d, 1 H), 7.81-8.22 (m, 2 H), 7.68 (br s, 1 H), 7.48-7.59 (m, 1 H), 7.43 (br d, 1 H), 6.60-7.20 (m, 4 H), 4.38-4.60 (m, 1 H), 3.49-3.88 (m, 1 H), 2.98-3.27 (m, 1 H), 2.83 (br d, 1 H), 2.36-2.52 (m, 1 H), 0.92-1.19 (m, 4 H) 502.2 [M+H] + 100%
2123 (CD 3OD) δ 8.67 (d, 1 H), 8.59 (br d, 1 H), 7.85-8.24 (m, 2 H), 7.68 (br s, 1 H), 7.48-7.58 (m, 1 H), 7.43 (br d, 1 H), 6.68-7.17 (m, 4 H), 4.28-4.59 (m, 1 H), 3.46-3.90 (m, 1 H), 2.96-3.28 (m, 1 H), 2.83 (br d, 1 H), 2.43 (br d, 1 H), 0.94-1.18 (m, 4 H) 502.2 [M+H] + 99.6%
2124 (CD 3OD) δ 8.55-8.80 (m, 2 H), 7.83-8.27 (m, 2 H), 7.59-7.78 (m, 2 H), 7.54 (br dd, 1 H), 6.98 (br t, 3 H), 4.59 (s, 1 H), 3.50-3.89 (m, 1 H), 3.01-3.25 (m, 1 H), 2.76-2.92 (m, 1 H), 2.35-2.54 (m, 1 H), 0.96-1.16 (m, 4 H) 520.2 [M+H] + 98.7%
2125 (CD 3OD) δ 8.63-8.76 (m, 2 H), 7.81-8.28 (m, 2 H), 7.45-7.76 (m, 3 H), 6.57-7.30 (m, 3 H), 4.42-4.68 (m, 1 H), 3.50-3.92 (m, 1 H), 2.95-3.26 (m, 1 H), 2.83 (br dd, 1 H), 2.37-2.53 (m, 1 H), 0.98-1.16 (m, 4 H) 520.2 [M+H] + 91.1%
2126 (CD 3OD) δ 8.31 (s, 1 H), 8.13 (br s, 1 H), 7.58 (br s, 1.7 H), 6.93-7.10 (m, 2.3 H), 6.40-6.87 (m, 4 H), 4.56 (br s, 1 H), 3.58 (br s, 1 H), 2.65-3.09 (m, 2 H), 2.44 (br s, 3 H) 331.2 [M+H] + 97.8%
2127 (CD 3OD) δ 8.31 (d, 1 H), 8.13 (br d, 1 H), 7.62 (s, 1 H), 7.58 (t, 1 H), 7.05 (d, 1 H), 6.97 (d, 1 H), 6.72-6.85 (m, 2 H), 6.63-6.70 (m, 1 H), 6.50 (s, 1 H), 4.57 (br dd, 1 H), 3.53-3.66 (m, 1 H), 2.87-3.05 (m, 1 H), 2.60-2.75 (m, 1 H), 2.42 (s, 3 H) 331.2 [M+H] + 95.2%
2128 (CD 3OD) δ 8.03 (dd, 2 H), 7.85 (d, 1 H), 7.69 (s, 1 H), 7.23-7.36 (m, 4 H), 6.74 (s, 1 H), 6.46 (br s, 1 H), 4.38 (dd, 1 H), 3.79 (td, 1 H), 3.01-3.21 (m, 1 H), 2.87 (br dd, 1 H) 470.2 [M+H] + 99.7%
2129 (CD 3OD) δ 8.03 (dd, 2 H), 7.85 (d, 1 H), 7.69 (s, 1 H), 7.23-7.36 (m, 4 H), 6.74 (s, 1 H), 6.46 (br s, 1 H), 4.38 (dd, 1 H), 3.79 (td, 1 H), 3.01-3.21 (m, 1 H), 2.87 (br dd, 1 H) 470.2 [M+H] + 94.3%
2130 (CD 3OD) δ 8.02 (dd, 2 H), 7.74 (d, 1 H), 7.68 (s, 1 H), 7.49 (s, 0.3 H), 7.36 (s, 0.5 H), 7.25-7.33 (m, 3 H), 7.16-7.23 (m, 1.2 H), 6.70 (s, 1 H), 6.46 (s, 1 H), 4.39 (dd, 1 H), 3.77-3.89 (m, 1 H), 3.04-3.17 (m, 1 H), 2.81-2.92 (m, 1 H) 452.2 [M+H] + 99.5%
2131 (CD 3OD) δ 8.01 (br t, 2 H), 7.74 (br d, 1 H), 7.68 (s, 1 H), 7.49 (s, 0.3 H), 7.35 (s, 0.5 H), 7.28 (q, 3 H), 7.13-7.23 (m, 1.2 H), 6.69 (s, 1 H), 6.45 (br s, 1 H), 4.38 (br dd, 1 H), 3.83 (br t, 1 H), 3.02-3.17 (m, 1 H), 2.86 (br d, 1 H) 452.1 [M+H] + 98.6%
2132 (CD 3OD) δ 7.86 (d, 1 H), 7.53-7.75 (m, 2 H), 7.11-7.41 (m, 4 H), 6.77 (s, 1 H), 6.42 (br s, 1 H), 4.39 (dd, 1 H), 3.73-3.93 (m, 1 H), 3.01-3.17 (m, 1 H), 2.86 (dd, 1 H) 488.2 [M+H] + 100%
2133 (CD 3OD) δ 7.86 (d, 1 H), 7.55-7.76 (m, 2 H), 7.11-7.44 (m, 4 H), 6.77 (s, 1 H), 6.42 (br s, 1 H), 4.39 (dd, 1 H), 3.83 (td, 1 H), 3.00-3.20 (m, 1 H), 2.86 (dd, 1 H) 488.2 [M+H]+ 97.1%
2134 (CD 3OD) δ 8.43 (d, 1 H), 7.50-7.75 (m, 3 H), 7.01-7.27 (m, 1 H), 6.76-6.94 (m, 2 H), 6.69 (s, 1 H), 6.50 (s, 1 H), 6.18 (dd, 1 H), 4.55 (dd, 1 H), 3.54 (ddd, 1 H), 2.83-3.01 (m, 1 H), 2.67 (br dd, 1 H) 335.1 [M+H] + 98.8%
2135 (CD 3OD) δ 8.43 (d, 1 H), 7.40-7.75 (m, 3 H), 7.06-7.27 (m, 1 H), 6.75-6.91 (m, 2 H), 6.69 (s, 1 H), 6.50 (s, 1 H), 6.18 (dd, 1 H), 4.55 (dd, 1 H), 3.54 (ddd, 1 H), 2.84-3.00 (m, 1 H), 2.67 (br dd, 1 H) 335.2 [M+H] + 98.9%
2136 (CD 3OD) δ 8.40 (s, 1 H), 7.76 (dd, 1 H), 7.63 (s, 1 H), 7.56 (dd, 1 H), 7.19 (d, 1 H), 7.15 (dd, 1 H), 7.00 (dd, 1 H), 6.85 (s, 1 H), 6.65 (s, 1 H), 4.81 (br dd, 1 H), 3.68 (ddd, 1 H), 2.87-3.04 (m, 1 H), 2.75 (dd, 1 H) 419.1 [M+H] + 100%
2137 (CD 3OD) δ 8.28 (s, 1 H), 7.65 (dd, 1 H), 7.52 (s, 1 H), 7.46 (dd, 1 H), 7.08 (d, 1 H), 7.04 (dd, 1 H), 6.90 (dd, 1 H), 6.73 (s, 1 H), 6.54 (s, 1 H), 4.69 (br dd, 1 H), 3.56 (ddd, 1 H), 2.76-2.91 (m, 1 H), 2.63 (dd, 1 H) 419.1 [M+H] + 100%
2138 (CD 3OD) δ 8.40 (s, 1 H), 7.76 (dd, 1 H), 7.67-7.73 (m, 1 H), 7.64 (s, 1 H), 7.30-7.60 (m, 1 H), 7.25 (dd, 1 H), 7.13-7.21 (m, 2 H), 6.82 (s, 1 H), 6.62 (s, 1 H), 4.83 (br dd, 1 H), 3.60-3.71 (m, 1 H), 2.89-3.02 (m, 1 H), 2.75 (dd, 1 H) 435.1 [M+H] + 100%
2139 (CD 3OD) δ 8.40 (s, 1 H), 7.76 (dd, 1 H), 7.71 (d, 1 H), 7.63 (s, 1 H), 7.30-7.59 (m, 1 H), 7.22-7.28 (m, 1 H), 7.14-7.21 (m, 2 H), 6.81 (s, 1 H), 6.62 (s, 1 H), 4.84 (br dd, 1 H), 3.59-3.72 (m, 1 H), 2.89-3.02 (m, 1 H), 2.75 (dd, 1 H) 435.1 [M+H] + 100%
2140 (CD 3OD) δ 8.52-8.94 (m, 1 H), 7.47-8.03 (m, 3 H), 6.91-7.19 (m, 1 H), 6.51-6.88 (m, 2 H), 4.65-4.80 (m, 0.5 H), 4.32-4.56 (m, 0.5 H), 3.51-3.88 (m, 1 H), 2.69-3.10 (m, 2 H), 2.18 (br d, 1 H), 1.02-1.27 (m, 4 H) 443.2 [M+H] + 100%
2141 (CD 3OD) δ 8.57-8.90 (m, 1 H), 7.44-8.06 (m, 3 H), 6.99 (br s, 1 H), 6.42-6.92 (m, 2 H), 4.64-4.82 (m, 0.5 H), 4.38-4.57 (m, 0.5 H), 3.42-3.89 (m, 1 H), 2.69-3.19 (m, 2 H), 2.18 (br s, 1 H), 0.98-1.23 (m, 4 H) 443.2 [M+H] + 99.6%
2142 (CD 3OD) δ 8.47-8.79 (m, 1 H), 7.43-7.82 (m, 3 H), 6.89 (br t, 1 H), 6.46-6.80 (m, 2 H), 4.53-4.74 (m, 1 H), 3.24-3.72 (m, 1 H), 2.61-3.06 (m, 2 H), 1.17-1.38 (m, 9 H) 459.2 [M+H]+ 100%
2143 (CD 3OD) δ 8.71 (br s, 1 H), 7.51-7.94 (m, 3 H), 6.52-7.18 (m, 3 H), 4.66-4.88 (m, 1 H), 3.37-3.91 (m, 1 H), 2.69-3.23 (m, 2 H), 1.26-1.58 (m, 9 H) 459.2 [M+H] + 99.5%
2144 (CD 3OD) δ 8.74 (br d, 1 H), 7.75-8.05 (m, 1 H), 7.60-7.73 (m, 2 H), 7.01 (br s, 1 H), 6.60-6.94 (m, 2 H), 4.82 (br s, 0.3 H), 4.48 (br s, 0.7 H), 3.78 (br s, 0.5 H), 3.36-3.48 (m, 0.5 H), 3.15 (br s, 1 H), 2.86 (br d, 1 H), 1.73-1.91 (m, 6 H) 463.2 [M+H] + 100%
2145 (CD 3OD) δ 8.72 (br s, 1 H), 7.75-8.09 (m, 1 H), 7.60-7.74 (m, 2 H), 7.01 (br s, 1 H), 6.56-6.95 (m, 2 H), 4.75-4.84 (m, 0.5 H), 4.48 (br s, 0.5 H), 3.78 (br s, 0.6 H), 3.36-3.47 (m, 0.4 H), 2.95-3.23 (m, 1 H), 2.84 (br s, 1 H), 1.69-1.92 (m, 6 H) 463.2 [M+H] + 98.5%
2146 (CD 3OD) δ 8.29 (d, 1 H), 7.74 (s, 1 H), 7.05 (d, 1 H), 6.84 (t, 1 H), 6.66 (s, 1 H), 6.40 (s, 1 H), 4.33 (dd, 1 H), 3.79 (ddd, 1 H), 2.99-3.25 (m, 2 H), 2.84 (br dd, 1 H), 1.33 (dd, 6 H) 418.2 [M+H] + 100%
2147 (CD 3OD) δ 8.31 (d, 1 H), 7.69 (s, 1 H), 7.07 (d, 1 H), 6.86 (t, 1 H), 6.67 (s, 1 H), 6.40 (s, 1 H), 4.35 (dd, 1 H), 3.81 (ddd, 1 H), 3.05-3.26 (m, 2 H), 2.85 (dd, 1 H), 1.35 (dd, 6 H) 418.2 [M+H] + 99.6%
2148 (CD 3OD) δ 8.42 (s, 1 H), 8.25-8.35 (m, 1 H), 7.73-7.82 (m, 1 H), 7.65 (s, 1 H), 7.11-7.18 (m, 1 H), 7.04 (d, 1 H), 6.92 (s, 1 H), 6.81 (t, 1 H), 6.60 (s, 1 H), 4.68-4.75 (m, 1 H), 3.56-3.70 (m, 1 H), 3.18 (dt, 1 H), 2.89-3.03 (m, 1 H), 2.74 (br dd, 1 H), 1.33 (dd, 6 H) 427.2 [M+H] + 98.7%
2149 (CD 3OD) δ 8.27-8.36 (m, 1 H), 8.13-8.23 (m, 1 H), 7.62-7.70 (m, 1 H), 7.46-7.57 (m, 1 H), 7.03 (d, 1 H), 6.92 (d, 1 H), 6.80 (s, 1 H), 6.70 (t, 1 H), 6.48 (s, 1 H), 4.60 (br dd, 1 H), 3.45-3.57 (m, 1 H), 3.07 (dt, 1 H), 2.77-2.91 (m, 1 H), 2.56-2.69 (m, 1 H), 1.21 (dd, 6 H) 427.2 [M+H] + 99.6%
2150 (CD 3OD) δ 7.96 (d, 1 H), 7.56 (s, 1 H), 6.63-7.05 (m, 2 H), 6.39-6.54 (m, 2 H), 6.25 (s, 1 H), 4.19 (dd, 1 H), 3.84 (s, 3 H), 3.54-3.72 (m, 1 H), 2.84-3.04 (m, 1 H), 2.71 (dd, 1 H) 388.2 [M+H] + 99.7%
2151 (CD 3OD) δ 8.07 (d, 1 H), 7.66 (s, 1 H), 7.10 (s, 0.2 H), 6.97 (s, 0.5 H), 6.73-6.87 (m, 1.3 H), 6.48-6.65 (m, 2 H), 6.35 (s, 1 H), 4.30 (dd, 1 H), 3.94 (s, 3 H), 3.66-3.79 (m, 1 H), 2.97-3.13 (m, 1 H), 2.81 (dd, 1 H) 388.2 [M+H] + 99.1%
2152 (CD 3OD) δ 8.36 (d, 1 H), 7.69 (s, 1 H), 7.10-7.26 (m, 0.5 H), 6.92-7.07 (m, 2 H), 6.80-6.90 (m, 1.5 H), 6.70 (s, 1 H), 6.39 (s, 1 H), 4.34 (dd, 1 H), 3.77 (ddd, 1 H), 2.98-3.20 (m, 1 H), 2.84 (dd, 1 H) 424.1 [M+H] + 99.7%
2153 (CD 3OD) δ 8.36 (d, 1 H), 7.69 (s, 1 H), 7.08-7.27 (m, 0.5 H), 6.93-7.07 (m, 2 H), 6.79-6.93 (m, 1.5 H), 6.70 (s, 1 H), 6.39 (s, 1 H), 4.34 (dd, 1 H), 3.77 (ddd, 1 H), 2.98-3.16 (m, 1 H), 2.84 (dd, 1 H) 424.1 [M+H] + 98.1%
2154 (CD 3OD) δ 8.24 (br d, 1 H), 7.59 (br s, 1 H), 7.10 (s, 0.2 H), 6.82-6.97 (m, 1.5 H), 6.68-6.81 (m, 1.3 H), 6.58 (s, 1 H), 6.29 (br s, 1 H), 4.23 (dd, 1 H), 3.55-3.76 (m, 1 H), 2.86-3.06 (m, 1 H), 2.74 (br d, 1 H) 442.1 [M+H] + 99.6%
2155 (CD 3OD) δ 8.24 (d, 1 H), 7.58 (s, 1 H), 7.10 (s, 0.3 H), 6.80-6.96 (m, 1.5 H), 6.70-6.78 (m, 1.2 H), 6.58 (s, 1 H), 6.29 (s, 1 H), 4.24 (dd, 1 H), 3.66 (ddd, 1 H), 2.88-3.05 (m, 1 H), 2.73 (dd, 1 H) 442.1 [M+H] + 99.1%
2156 (CD 3OD) δ 9.23 (s, 1 H), 8.67 (br d, 2 H), 8.24 (br d, 1 H), 7.68 (s, 1 H), 6.92 (br d, 1 H), 6.67-6.78 (m, 1 H), 6.42-6.63 (m, 2 H), 4.41 (br dd, 1 H), 3.70-3.87 (m, 1 H), 2.96-3.14 (m, 1 H), 2.77-2.88 (m, 1 H), 2.38 (s, 3 H) 400.2 [M+H] + 99.4%
2157 (CD 3OD) δ 9.28 (d, 1 H), 8.66-8.77 (m, 2 H), 8.29 (d, 1 H), 7.68 (s, 1 H), 6.97 (d, 1 H), 6.76 (t, 1 H), 6.63 (s, 1 H), 6.51 (s, 1 H), 4.43 (dd, 1 H), 3.81 (ddd, 1 H), 3.03-3.15 (m, 1 H), 2.84 (dd, 1 H), 2.43 (s, 3 H) 400.2 [M+H] + 99.4%
2158 (CD 3OD) δ 9.24 (s, 1 H), 8.68 (br dd, 2 H), 8.30 (br d, 1 H), 7.68 (s, 1 H), 6.91 (br dd, 1 H), 6.69-6.84 (m, 2 H), 6.49 (br s, 1 H), 4.43 (br dd, 1 H), 3.73-3.86 (m, 1 H), 3.00-3.17 (m, 1 H), 2.84 (br dd, 1 H) 404.2 [M+H] + 99.9%
2159 (CD 3OD) δ 9.23 (s, 1 H), 8.62-8.71 (m, 2 H), 8.28 (d, 1 H), 7.68 (s, 1 H), 6.90 (dd, 1 H), 6.69-6.82 (m, 2 H), 6.49 (s, 1 H), 4.42 (br dd, 1 H), 3.73-3.86 (m, 1 H), 3.00-3.14 (m, 1 H), 2.83 (br dd, 1 H) 404.2 [M+H] + 99.0%
2160 (CD 3OD) δ 9.27 (s, 1 H), 8.70 (br dd, 2 H), 8.42 (br d, 1 H), 7.69 (s, 1 H), 7.27 (br d, 1 H), 6.82 (t, 1 H), 6.75 (s, 1 H), 6.51 (s, 1 H), 4.45 (br dd, 1 H), 3.75-3.86 (m, 1 H), 3.03-3.15 (m, 1 H), 2.85 (br dd, 1 H) 420.1 [M+H] + 100%
2161 (CD 3OD) δ 9.26 (s, 1 H), 8.65-8.77 (m, 2 H), 8.40 (d, 1 H), 7.69 (s, 1 H), 7.25 (d, 1 H), 6.80 (t, 1 H), 6.74 (s, 1 H), 6.50 (s, 1 H), 4.44 (dd, 1 H), 3.69-3.89 (m, 1 H), 3.00-3.20 (m, 1 H), 2.84 (br dd, 1 H) 420.1 [M+H] + 98.8%
2162 (CD 3OD) δ 9.27 (d, 1 H), 8.94 (d, 1 H), 8.67 (d, 1 H), 8.09 (dd, 1 H), 7.69 (s, 1 H), 7.61 (d, 1 H), 6.96 (t, 1 H), 6.82 (s, 1 H), 6.55 (s, 1 H), 4.49 (dd, 1 H), 3.82 (ddd, 1 H), 3.04-3.18 (m, 1 H), 2.86 (dd, 1 H) 454.2 [M+H] + 99.5%
2163 (CD 3OD) δ 9.27 (d, 1 H), 8.94 (d, 1 H), 8.68 (d, 1 H), 8.10 (dd, 1 H), 7.69 (s, 1 H), 7.61 (d, 1 H), 6.97 (t, 1 H), 6.82 (s, 1 H), 6.55 (br s, 1 H), 4.49 (dd, 1 H), 3.72-3.92 (m, 1 H), 3.01-3.19 (m, 1 H), 2.86 (br dd, 1 H) 454.2 [M+H] + 96.9%
2164 (CD 3OD) δ 8.07 (d, 1 H), 7.67 (s, 1 H), 6.79 (t, 1 H), 6.53-6.64 (m, 2 H), 6.36 (s, 1 H), 4.31 (dd, 1 H), 3.94 (s, 3 H), 3.75 (td, 1 H), 2.99-3.14 (m, 1 H), 2.82 (br dd, 1 H) 406.1 [M+H] + 100%
2165 (CD 3OD) δ 8.07 (d, 1 H), 7.67 (s, 1 H), 6.79 (t, 1 H), 6.50-6.65 (m, 2 H), 6.36 (br s, 1 H), 4.31 (dd, 1 H), 3.95 (s, 3 H), 3.69-3.83 (m, 1 H), 2.99-3.12 (m, 1 H), 2.76-2.87 (m, 1 H) 406.1 [M+H] + 99.6%
2166 (CD 3OD) δ 8.16 (d, 1 H), 7.57 (s, 1 H), 6.59-7.03 (m, 4 H), 6.28 (s, 1 H), 4.21 (dd, 1 H), 3.67 (ddd, 1 H), 2.83-3.03 (m, 1 H), 2.72 (dd, 1 H), 1.78-2.10 (m, 1 H), 0.88-0.96 (m, 2 H), 0.62-0.71 (m, 2 H) 398.2 [M+H] + 90.7%
2167 (CD 3OD) δ 8.17 (d, 1 H), 7.58 (s, 1 H), 6.56-7.04 (m, 4 H), 6.28 (s, 1 H), 4.21 (dd, 1 H), 3.67 (td, 1 H), 2.85-3.06 (m, 1 H), 2.72 (dd, 1 H), 1.87-2.06 (m, 1 H), 0.86-1.01 (m, 2 H), 0.63-0.73 (m, 2 H) 398.2 [M+H] + 100%
2168 (CD 3OD) δ 8.31 (br d, 1 H), 7.66 (s, 1 H), 7.06 (d, 1 H), 6.84 (t, 1 H), 6.59 (s, 1 H), 6.14-6.33 (m, 1 H), 4.19 (dd, 1 H), 3.70 (td, 1 H), 3.20 (dt, 1 H), 2.95-3.10 (m, 1 H), 2.73-2.87 (m, 1 H), 2.02-2.15 (m, 1 H), 1.34 (dd, 6 H), 1.04-1.15 (m, 4 H) 390.2 [M+H] + 98.6%
2169 (CD 3OD) δ 8.19 (d, 1 H), 7.54 (s, 1 H), 6.94 (d, 1 H), 6.72 (t, 1 H), 6.47 (s, 1 H), 6.14 (br s, 1 H), 4.07 (dd, 1 H), 3.58 (td, 1 H), 3.08 (dt, 1 H), 2.85-2.96 (m, 1 H), 2.67 (br dd, 1 H), 1.92-2.05 (m, 1 H), 1.22 (dd, 6 H), 0.92-1.03 (m, 4 H) 390.2 [M+H] + 97.5%
2170 (CD 3OD) δ 8.30 (s, 1 H), 8.16 (d, 1 H), 7.65 (dd, 1 H), 7.54 (s, 1 H), 7.03 (d, 1 H), 6.81 (s, 1 H), 6.59-6.70 (m, 2 H), 6.57 (s, 1 H), 4.60 (br dd, 1 H), 3.44-3.58 (m, 1 H), 2.78-2.91 (m, 1 H), 2.62 (dd, 1 H), 1.89-2.02 (m, 1 H), 0.86-0.96 (m, 2 H), 0.59-0.69 (m, 2 H) 425.2 [M+H] + 80.9%
2171 (CD 3OD) δ 8.30 (s, 1 H), 8.16 (d, 1 H), 7.65 (dd, 1 H), 7.54 (s, 1 H), 7.03 (d, 1 H), 6.82 (s, 1 H), 6.60-6.70 (m, 2 H), 6.57 (s, 1 H), 4.60 (br dd, 1 H), 3.44-3.57 (m, 1 H), 2.79-2.90 (m, 1 H), 2.62 (dd, 1 H), 1.91-2.01 (m, 1 H), 0.85-0.96 (m, 2 H), 0.61-0.69 (m, 2 H) 425.2 [M+H] + 96.3%
2172 (CD 3OD) δ 8.40 (d, 2 H), 8.25 (d, 1 H), 7.64 (s, 1 H), 7.22 (s, 1 H), 6.70-6.81 (m, 2 H), 6.69 (s, 1 H), 6.64 (t, 1 H), 5.03 (dd, 1 H), 3.48 (ddd, 1 H), 2.85-2.98 (m, 1 H), 2.70 (dd, 1 H), 2.01-2.13 (m, 1 H), 0.97-1.07 (m, 2 H), 0.71-0.81 (m, 2 H) 358.2 [M+H] + 100%
2173 (CD 3OD) δ 8.41 (d, 2 H), 8.25 (d, 1 H), 7.64 (s, 1 H), 7.22 (s, 1 H), 6.71-6.80 (m, 2 H), 6.69 (s, 1 H), 6.65 (t, 1 H), 5.04 (dd, 1 H), 3.48 (ddd, 1 H), 2.84-3.00 (m, 1 H), 2.70 (dd, 1 H), 2.00-2.13 (m, 1 H), 0.97-1.07 (m, 2 H), 0.70-0.81 (m, 2 H) 358.2 [M+H] + 100%
2174 (CD 3OD) δ 8.56 (s, 2 H), 8.14 (d, 1 H), 7.55 (s, 1 H), 7.16 (s, 1 H), 6.52-6.74 (m, 3 H), 5.06 (dd, 1 H), 3.42 (td, 1 H), 2.74-2.87 (m, 1 H), 2.60-2.69 (m, 1 H), 1.89-2.06 (m, 1 H), 0.84-0.95 (m, 2 H), 0.59-0.71 (m, 2 H) 426.2 [M+H] + 100%
2175 (CD 3OD) δ 8.56 (s, 2 H), 8.14 (d, 1 H), 7.55 (s, 1 H), 7.16 (s, 1 H), 6.54-6.73 (m, 3 H), 5.07 (dd, 1 H), 3.42 (td, 1 H), 2.72-2.90 (m, 1 H), 2.57-2.71 (m, 1 H), 1.86-2.06 (m, 1 H), 0.85-0.97 (m, 2 H), 0.59-0.73 (m, 2 H) 426.2 [M+H] + 99.7%
2176 (CD 3OD) δ 9.28 (d, 1 H), 8.67-8.75 (m, 2 H), 8.28 (d, 1 H), 7.68 (s, 1 H), 7.03 (d, 1 H), 6.81 (t, 1 H), 6.72 (s, 1 H), 6.51 (s, 1 H), 4.43 (dd, 1 H), 3.82 (td, 1 H), 3.04-3.23 (m, 2 H), 2.85 (dd, 1 H), 1.29-1.35 (m, 6 H) 428.2 [M+H] + 100%
2177 (CD 3OD) δ 9.29 (d, 1 H), 8.68-8.75 (m, 2 H), 8.29 (d, 1 H), 7.68 (s, 1 H), 7.04 (d, 1 H), 6.82 (t, 1 H), 6.72 (s, 1 H), 6.51 (s, 1 H), 4.44 (dd, 1 H), 3.77-3.88 (m, 1 H), 3.04-3.25 (m, 2 H), 2.85 (dd, 1 H), 1.29-1.35 (m, 6 H) 428.2 [M+H] + 99.0%
2178 (CD 3OD) δ 9.27 (d, 1 H), 8.94 (d, 1 H), 8.32 (br d, 1 H), 8.10 (dd, 1 H), 7.69 (br s, 1 H), 6.95 (dd, 1 H), 6.73-6.86 (m, 2 H), 6.52 (s, 1 H), 4.47 (dd, 1 H), 3.72-3.89 (m, 1 H), 2.98-3.17 (m, 1 H), 2.86 (br d, 1 H) 404.2 [M+H] + 100%
2179 (CD 3OD) δ 9.28 (d, 1 H), 8.95 (d, 1 H), 8.33 (br d, 1 H), 8.10 (dd, 1 H), 7.69 (br s, 1 H), 6.95 (dd, 1 H), 6.73-6.87 (m, 2 H), 6.53 (s, 1 H), 4.47 (br dd, 1 H), 3.69-3.91 (m, 1 H), 3.01-3.16 (m, 1 H), 2.78-2.93 (m, 1 H) 404.2 [M+H] + 94.6%
2180 (CD 3OD) δ 9.28 (d, 1 H), 8.95 (d, 1 H), 8.29 (d, 1 H), 8.11 (dd, 1 H), 7.68 (s, 1 H), 7.04 (d, 1 H), 6.82 (t, 1 H), 6.72 (s, 1 H), 6.52 (br s, 1 H), 4.46 (dd, 1 H), 3.83 (ddd, 1 H), 3.02-3.24 (m, 2 H), 2.86 (br dd, 1 H), 1.32 (dd, 6 H) 428.2 [M+H] + 100%
2181 (CD 3OD) δ 9.27 (s, 1 H), 8.94 (d, 1 H), 8.28 (d, 1 H), 8.10 (d, 1 H), 7.68 (s, 1 H), 7.04 (d, 1 H), 6.82 (t, 1 H), 6.72 (s, 1 H), 6.52 (br s, 1 H), 4.46 (dd, 1 H), 3.75-3.93 (m, 1 H), 3.00-3.23 (m, 2 H), 2.86 (br dd, 1 H), 1.28-1.34 (m, 6 H) 428.2 [M+H] + 97.8%
2182 (CD 3OD) δ 9.27 (s, 1 H), 8.94 (d, 1 H), 8.42 (d, 1 H), 8.10 (dd, 1 H), 7.69 (s, 1 H), 7.27 (d, 1 H), 6.82 (t, 1 H), 6.76 (s, 1 H), 6.53 (br s, 1 H), 4.47 (dd, 1 H), 3.81 (td, 1 H), 3.01-3.16 (m, 1 H), 2.86 (br dd, 1 H) 420.1 [M+H] + 100%
2183 (CD 3OD) δ 9.26 (s, 1 H), 8.94 (d, 1 H), 8.42 (d, 1 H), 8.09 (d, 1 H), 7.69 (s, 1 H), 7.27 (d, 1 H), 6.82 (t, 1 H), 6.75 (s, 1 H), 6.52 (s, 1 H), 4.47 (dd, 1 H), 3.70-3.89 (m, 1 H), 3.00-3.16 (m, 1 H), 2.85 (br dd, 1 H) 420.1 [M+H] + 96.9%
2184 (CD 3OD) δ 8.68 (s, 2 H), 8.29 (d, 1 H), 7.66 (s, 1 H), 7.26 (s, 1 H), 7.05 (d, 1 H), 6.82 (t, 1 H), 6.63 (s, 1 H), 5.18 (dd, 1 H), 3.47-3.60 (m, 1 H), 3.19 (dt, 1 H), 2.86-2.99 (m, 1 H), 2.70-2.81 (m, 1 H), 1.34 (dd, 6 H) 428.2 [M+H] + 100%
2185 (CD 3OD) δ 8.66 (s, 2 H), 8.27 (d, 1 H), 7.67 (s, 1 H), 7.25 (s, 1 H), 7.03 (d, 1 H), 6.80 (t, 1 H), 6.61 (s, 1 H), 5.17 (dd, 1 H), 3.46-3.59 (m, 1 H), 3.17 (dt, 1 H), 2.85-2.98 (m, 1 H), 2.69-2.79 (m, 1 H), 1.32 (dd, 6 H) 428.2 [M+H] + 100%
2186 (CD 3OD) δ 8.29 (d, 1 H), 7.67 (s, 1 H), 6.74-6.85 (m, 2 H), 6.69 (s, 1 H), 6.31 (s, 1 H), 4.22 (dd, 1 H), 3.64-3.78 (m, 1 H), 2.97-3.10 (m, 1 H), 2.79 (dd, 1 H), 2.45 (s, 3 H), 2.04-2.15 (m, 1 H), 1.00-1.07 (m, 2 H), 0.75-0.83 (m, 2 H) 362.2 [M+H] + 99.7%
2187 (CD 3OD) δ 8.29 (d, 1 H), 7.67 (s, 1 H), 6.75-6.85 (m, 2 H), 6.69 (s, 1 H), 6.31 (s, 1 H), 4.22 (dd, 1 H), 3.71 (ddd, 1 H), 2.95-3.12 (m, 1 H), 2.79 (dd, 1 H), 2.45 (s, 3 H), 1.99-2.21 (m, 1 H), 0.99-1.08 (m, 2 H), 0.73-0.82 (m, 2 H) 362.2 [M+H] + 91.9%
2188 (CD 3OD) δ 8.31 (d, 1 H), 7.67 (s, 1 H), 6.99 (d, 1 H), 6.79 (t, 1 H), 6.52 (s, 1 H), 6.24 (s, 1 H), 4.18 (dd, 1 H), 3.64-3.76 (m, 1 H), 2.96-3.08 (m, 1 H), 2.79 (dd, 1 H), 2.44 (s, 3 H), 1.50 (s, 3 H), 1.23-1.31 (m, 2 H), 0.91-0.97 (m, 2 H) 376.2 [M+H] + 99.8%
2189 (CD 3OD) δ 8.31 (d, 1 H), 7.67 (s, 1 H), 6.99 (d, 1 H), 6.79 (t, 1 H), 6.52 (s, 1 H), 6.24 (s, 1 H), 4.18 (dd, 1 H), 3.62-3.76 (m, 1 H), 2.94-3.09 (m, 1 H), 2.79 (dd, 1 H), 2.44 (s, 3 H), 1.50 (s, 3 H), 1.24-1.31 (m, 2 H), 0.90-0.99 (m, 2 H) 376.2 [M+H] + 99.8%
2190 (CD 3OD) δ 8.32 (d, 1 H), 7.51-7.58 (m, 1 H), 7.46 (d, 1 H), 7.02-7.11 (m, 1 H), 6.70-6.78 (m, 1 H), 6.45 (s, 1 H), 6.25 (s, 1 H), 4.18 (dd, 1 H), 3.64 (ddd, 1 H), 2.85-3.00 (m, 1 H), 2.70 (dd, 1 H), 1.92-2.06 (m, 3 H) 372.1 [M+H] + 100%
2191 (CD 3OD) δ 8.32 (d, 1 H), 7.56 (s, 1 H), 7.47 (d, 1 H), 6.99-7.13 (m, 1 H), 6.74 (t, 1 H), 6.45 (s, 1 H), 6.25 (s, 1 H), 4.18 (dd, 1 H), 3.64 (ddd, 1 H), 2.87-3.00 (m, 1 H), 2.70 (dd, 1 H), 1.99 (t, 3 H) 372.1 [M+H] + 99.9%
2192 (CD 3OD) δ 8.31 (d, 1 H), 7.69 (s, 1 H), 7.00 (d, 1 H), 6.80 (t, 1 H), 6.59 (s, 1 H), 6.38 (s, 1 H), 4.31 (dd, 1 H), 3.73-3.84 (m, 1 H), 3.00-3.15 (m, 1 H), 2.84 (dd, 1 H), 2.45 (s, 3 H), 2.12 (t, 3 H) 386.2 [M+H] + 100%
2193 (CD 3OD) δ 8.31 (d, 1 H), 7.69 (s, 1 H), 7.00 (d, 1 H), 6.80 (t, 1 H), 6.59 (s, 1 H), 6.38 (br s, 1 H), 4.31 (dd, 1 H), 3.78 (ddd, 1 H), 2.95-3.13 (m, 1 H), 2.83 (br dd, 1 H), 2.45 (s, 3 H), 2.12 (t, 3 H) 386.2 [M+H] + 100%
2194 (CD 3OD) δ 8.70 (d, 1 H), 7.70 (s, 1 H), 7.64 (d, 1 H), 6.96-7.03 (m, 1 H), 6.71-6.80 (m, 1 H), 6.41 (s, 1 H), 4.35 (dd, 1 H), 3.71-3.85 (m, 1 H), 3.02-3.13 (m, 1 H), 2.85 (dd, 1 H), 2.03-2.19 (m, 3 H) 440.2 [M+H] + 99.9%
2195 (CD 3OD) δ 8.69 (d, 1 H), 7.69 (s, 1 H), 7.63 (d, 1 H), 6.99 (t, 1 H), 6.76 (s, 1 H), 6.40 (br s, 1 H), 4.34 (dd, 1 H), 3.70-3.84 (m, 1 H), 3.01-3.14 (m, 1 H), 2.85 (br dd, 1 H), 2.11 (t, 3 H) 440.2 [M+H] + 99.4%
2196 (CD 3OD) δ 8.35 (d, 1 H), 7.69 (s, 1 H), 6.97 (dd, 1 H), 6.80-6.87 (m, 1 H), 6.69-6.74 (m, 1 H), 6.38 (s, 1 H), 4.27-4.38 (m, 1 H), 3.71-3.85 (m, 1 H), 3.01-3.12 (m, 1 H), 2.84 (dd, 1 H), 2.12 (t, 3 H) 390.2 [M+H] + 99.4%
2197 (CD 3OD) δ 8.35 (d, 1 H), 7.69 (s, 1 H), 6.97 (dd, 1 H), 6.84 (td, 1 H), 6.72 (s, 1 H), 6.38 (s, 1 H), 4.27-4.39 (m, 1 H), 3.78 (ddd, 1 H), 3.01-3.14 (m, 1 H), 2.84 (dd, 1 H), 2.12 (t, 3 H) 390.2 [M+H] + 99.8%
2198 (CD 3OD) δ 9.29 (dd, 1 H), 8.25-8.52 (m, 2 H), 7.89 (dd, 1 H), 7.70 (s, 1 H), 7.29 (d, 1 H), 6.73-6.95 (m, 2 H), 6.57 (br s, 1 H), 4.50 (dd, 1 H), 3.74-3.95 (m, 1 H), 3.12 (br d, 1 H), 2.88 (br dd, 1 H) 420.1 [M+H] + 100%
2199 (CD 3OD) δ 9.19-9.41 (m, 1 H), 8.25-8.55 (m, 2 H), 7.89 (dd, 1 H), 7.71 (s, 1 H), 7.29 (d, 1 H), 6.73-6.91 (m, 2 H), 6.57 (s, 1 H), 4.50 (dd, 1 H), 3.68-4.01 (m, 1 H), 3.03-3.23 (m, 1 H), 2.87 (dd, 1 H) 420.1 [M+H] + 98.6%
2200 (CD 3OD) δ 8.65 (s, 2 H), 8.04 (d, 1 H), 7.63 (s, 1 H), 7.21 (s, 1 H), 6.75 (t, 1 H), 6.48-6.63 (m, 2 H), 5.15 (dd, 1 H), 3.93 (s, 3 H), 3.41-3.57 (m, 1 H), 2.84-2.95 (m, 1 H), 2.66-2.80 (m, 1 H) 416.2 [M+H] + 100%
2201 (CD 3OD) δ 8.65 (s, 2 H), 8.04 (d, 1 H), 7.64 (s, 1 H), 7.21 (s, 1 H), 6.75 (t, 1 H), 6.45-6.61 (m, 2 H), 5.15 (dd, 1 H), 3.93 (s, 3 H), 3.41-3.57 (m, 1 H), 2.82-2.97 (m, 1 H), 2.69-2.78 (m, 1 H) 416.2 [M+H] + 98.9%
2202 (CD 3OD) δ 8.59 (d, 1 H), 7.69 (s, 1 H), 7.44 (br d, 1 H), 6.83-7.14 (m, 2 H), 6.76 (s, 1 H), 6.40 (s, 1 H), 4.33 (dd, 1 H), 3.77 (ddd, 1 H), 3.00-3.14 (m, 1 H), 2.84 (dd, 1 H), 2.12 (t, 3 H) 422.2 [M+H] + 96.6%
2203 (CD 3OD) δ 8.59 (d, 1 H), 7.69 (s, 1 H), 7.44 (br d, 1 H), 6.82-7.15 (m, 2 H), 6.76 (s, 1 H), 6.40 (s, 1 H), 4.33 (dd, 1 H), 3.77 (ddd, 1 H), 2.99-3.13 (m, 1 H), 2.84 (br dd, 1 H), 2.12 (t, 3 H) 422.2 [M+H] + 99.9%
2204 (CD 3OD) δ 8.28 (d, 1 H), 7.69 (s, 1 H), 6.67-6.87 (m, 3 H), 6.39 (br s, 1 H), 4.32 (dd, 1 H), 3.79 (ddd, 1 H), 3.00-3.13 (m, 1 H), 2.84 (br dd, 1 H), 2.02-2.18 (m, 4 H), 0.97-1.08 (m, 2 H), 0.71-0.82 (m, 2 H) 412.2 [M+H] + 99.7%
2205 (CD 3OD) δ 8.28 (br d, 1 H), 7.69 (br s, 1 H), 6.73-6.84 (m, 3 H), 6.39 (br s, 1 H), 4.32 (dd, 1 H), 3.72-3.88 (m, 1 H), 3.00-3.15 (m, 1 H), 2.77-2.92 (m, 1 H), 2.06-2.17 (m, 4 H), 1.00-1.08 (m, 2 H), 0.75-0.81 (m, 2 H) 412.2 [M+H] + 99.9%
2206 (CD 3OD) δ 8.54 (dd, 1 H), 8.22-8.42 (m, 2 H), 7.69 (s, 1 H), 7.45 (dd, 1 H), 6.99 (d, 1 H), 6.78 (t, 1 H), 6.59 (s, 1 H), 6.46 (br s, 1 H), 4.39 (dd, 1 H), 3.71-3.92 (m, 1 H), 3.05-3.19 (m, 1 H), 2.88 (s, 4 H), 2.44 (s, 3 H) 413.2 [M+H] + 99.6%
2207 (CD 3OD) δ 8.47-8.62 (m, 1 H), 8.32 (t, 2 H), 7.76 (s, 1 H), 7.45 (dd, 1 H), 6.99 (d, 1 H), 6.78 (t, 1 H), 6.60 (s, 1 H), 6.47 (s, 1 H), 4.40 (dd, 1 H), 3.73-3.90 (m, 1 H), 3.02-3.20 (m, 1 H), 2.81-2.93 (m, 4 H), 2.44 (s, 3 H) 413.2 [M+H] + 99.1%
2208 (CD 3OD) δ 8.71 (br d, 1 H), 8.55 (d, 1 H), 8.33 (d, 1 H), 7.57-7.78 (m, 2 H), 7.45 (dd, 1 H), 6.99 (t, 1 H), 6.78 (s, 1 H), 6.49 (br s, 1 H), 4.43 (dd, 1 H), 3.74-3.90 (m, 1 H), 3.05-3.19 (m, 1 H), 2.80-2.94 (m, 4 H) 467.2 [M+H] + 100%
2209 (CD 3OD) δ 8.71 (br d, 1 H), 8.55 (dd, 1 H), 8.33 (dd, 1 H), 7.56-7.80 (m, 2 H), 7.46 (dd, 1 H), 6.99 (br t, 1 H), 6.78 (s, 1 H), 6.49 (br s, 1 H), 4.43 (dd, 1 H), 3.82 (br d, 1 H), 3.02-3.20 (m, 1 H), 2.89 (s, 4 H) 467.2 [M+H] + 99.5%
2210 (CD 3OD) δ 8.13-8.89 (m, 3 H), 7.71 (s, 1 H), 7.37-7.54 (m, 2 H), 6.72-7.18 (m, 3 H), 6.48 (s, 1 H), 4.41 (dd, 1 H), 3.67-3.94 (m, 1 H), 3.05-3.19 (m, 1 H), 2.74-3.01 (m, 4 H) 449.2 [M+H] + 99.9%
2211 (CD 3OD) δ 8.48-8.70 (m, 2 H), 8.33 (dd, 1 H), 7.70 (s, 1 H), 7.36-7.60 (m, 2 H), 6.73-7.17 (m, 3 H), 6.48 (s, 1 H), 4.41 (dd, 1 H), 3.81 (ddd, 1 H), 3.03-3.18 (m, 1 H), 2.77-2.97 (m, 4 H) 449.2 [M+H] + 99.6%
2212 (CD 3OD) δ 8.54 (dd, 1 H), 8.22-8.42 (m, 2 H), 7.69 (s, 1 H), 7.45 (dd, 1 H), 6.99 (d, 1 H), 6.78 (t, 1 H), 6.59 (s, 1 H), 6.46 (br s, 1 H), 4.39 (dd, 1 H), 3.71-3.92 (m, 1 H), 3.05-3.19 (m, 1 H), 2.88 (s, 4 H), 2.44 (s, 3 H) 413.2 [M+H] + 99.6%
2213 (CD 3OD) δ 8.41 (dd, 1 H), 8.10-8.30 (m, 2 H), 7.58 (s, 1 H), 7.32 (dd, 1 H), 6.53-6.90 (m, 3 H), 6.34 (s, 1 H), 4.28 (dd, 1 H), 3.69 (ddd, 1 H), 2.90-3.07 (m, 1 H), 2.65-2.87 (m, 4 H) 417.2 [M+H] + 98.9%
2214 (CD 3OD) δ 8.25-8.34 (m, 1 H), 7.69 (br d, 1 H), 6.92-7.01 (m, 2 H), 6.82-6.91 (m, 1 H), 6.77 (dt, 1 H), 6.34-6.72 (m, 1 H), 4.44 (dd, 1 H), 4.10 (s, 3 H), 3.62-3.77 (m, 0.6 H), 3.10-3.28 (m, 1 H), 2.92-3.05 (m, 0.4 H), 2.68-2.87 (m, 1 H), 2.34-2.48 (m, 3 H) 413.1 [M+H] + 100%
2215 (CD 3OD) δ 8.23-8.38 (m, 1 H), 7.70 (br s, 1 H), 6.92-7.02 (m, 2 H), 6.82-6.91 (m, 1 H), 6.77 (dt, 1 H), 6.35-6.72 (m, 1 H), 4.44 (br dd, 1 H), 4.10 (s, 3 H), 3.58-3.77 (m, 0.6 H), 3.11-3.30 (m, 1 H), 2.93-3.03 (m, 0.4 H), 2.67-2.87 (m, 1 H), 2.35-2.49 (m, 3 H) 413.1 [M+H] + 100%
2216 (CD 3OD) δ 8.46 (br s, 1 H), 7.70 (s, 2 H), 7.32 (d, 1 H), 6.59-6.92 (m, 3 H), 4.42-4.80 (m, 1 H), 3.75 (br s, 1 H), 2.96-3.22 (m, 1 H), 2.84 (br d, 1 H), 1.66 (br s, 6 H) 427.1 [M+H] + 100%
2217 (CD 3OD) δ 8.46 (br s, 1 H), 7.59-8.02 (m, 2 H), 7.31 (br s, 1 H), 6.61-6.93 (m, 3 H), 4.35-4.65 (m, 1 H), 3.75 (br s, 1 H), 3.14 (br s, 1 H), 2.82 (br s, 1 H), 1.64 (br s, 6 H) 427.1 [M+H] 99.4%
2218 (CD 3OD) δ 8.44-8.54 (m, 1 H), 7.70 (s, 1 H), 7.48 (s, 0.3 H), 7.16-7.25 (m, 1 H), 6.87-6.98 (m, 1.7 H), 6.66-6.81 (m, 1 H), 4.91-5.05 (m, 1 H), 3.75 (ddd, 0.6 H), 3.36-3.45 (m, 0.4 H), 2.81-3.20 (m, 2 H), 2.62-2.69 (m, 3 H) 434.1 [M+H] + 100%
2219 (CD 3OD) δ 8.28-8.42 (m, 1 H), 7.58 (s, 1 H), 7.36 (s, 0.3 H), 6.98-7.14 (m, 1 H), 6.72-6.88 (m, 1.7 H), 6.58-6.68 (m, 1 H), 4.87 (br dd, 1 H), 3.63 (ddd, 0.6 H), 3.27 (td, 0.4 H), 2.67-3.09 (m, 2 H), 2.48-2.57 (m, 3 H) 434.1 [M+H] + 99.8%
2220 (CD 3OD) δ 7.73 (d, 1 H), 7.66 (s, 1 H), 7.32-7.50 (m, 0.7 H), 7.23-7.30 (m, 1 H), 7.16-7.22 (m, 1.3 H), 6.78-7.12 (m, 1 H), 6.66 (s, 1 H), 6.37 (br s, 1 H), 4.33 (dd, 1 H), 3.70-3.89 (m, 1 H), 2.99-3.10 (m, 1 H), 2.76-2.88 (m, 1 H) 408.1 [M+H] + 99.5%
2221 (CD 3OD) δ 7.72 (d, 1 H), 7.66 (s, 1 H), 7.31-7.50 (m, 0.8 H), 7.23-7.30 (m, 1 H), 7.18 (t, 1.2 H), 6.81-7.12 (m, 1 H), 6.66 (s, 1 H), 6.38 (s, 1 H), 4.33 (dd, 1 H), 3.79 (ddd, 1 H), 2.97-3.11 (m, 1 H), 2.82 (dd, 1 H) 408.2 [M+H] + 98.7%
2222 (CD 3OD) δ 8.27-8.39 (m, 1 H), 7.65 (s, 1 H), 6.88-7.02 (m, 1.8 H), 6.81 (td, 1 H), 6.53-6.69 (m, 1.2 H), 4.85 (br s, 0.3 H), 4.36 (dd, 0.7 H), 3.70 (ddd, 0.8 H), 3.36-3.41 (m, 0.2 H), 3.10 (ddd, 0.8 H), 2.69-2.95 (m, 2.2 H), 2.01-2.11 (m, 1 H), 1.75-1.88 (m, 1 H) 362.1 [M+H] + 97.2%
2223 (CD 3OD) δ 8.23-8.44 (m, 1 H), 7.67 (d, 1 H), 6.71-7.01 (m, 2.5 H), 6.33-6.67 (m, 1.5 H), 4.76 (dd, 0.5 H), 4.33 (dd, 0.5 H), 3.70 (ddd, 0.5 H), 3.39-3.52 (m, 0.5 H), 2.95-3.22 (m, 1.5 H), 2.66-2.88 (m, 1.5 H), 2.05-2.19 (m, 1 H), 1.76-1.93 (m, 1 H) 362.1 [M+H] + 90.7%
2224 (CD 3OD) δ 8.34 (br s, 1 H), 7.95-8.23 (m, 2 H), 7.34-7.74 (m, 2 H), 6.49-6.80 (m, 4 H), 4.54 (br s, 1 H), 3.41-3.62 (m, 1 H), 2.78-2.94 (m, 1 H), 2.67 (br dd, 1 H), 1.86-2.04 (m, 1 H), 0.89 (br d, 2 H), 0.63 (br d, 2 H) 358.2 [M+H] + 100%
2225 (CD 3OD) δ 8.33 (br s, 1 H), 7.96-8.22 (m, 2 H), 7.35-7.76 (m, 2 H), 6.50-6.80 (m, 4 H), 4.55 (br s, 1 H), 3.42-3.61 (m, 1 H), 2.81-2.96 (m, 1 H), 2.56-2.79 (m, 1 H), 1.82-2.03 (m, 1 H), 0.88 (br d, 2 H), 0.63 (br d, 2 H) 358.2 [M+H] + 98.3%
2226 (CD 3OD) δ 8.15 (d, 1 H), 7.55 (s, 1 H), 6.61-6.72 (m, 2 H), 6.55 (s, 1 H), 6.13 (s, 1 H), 4.06 (dd, 1 H), 3.59 (ddd, 1 H), 2.84-2.97 (m, 1 H), 2.68 (dd, 1 H), 1.91-2.02 (m, 1 H), 1.38 (s, 3 H), 1.12-1.18 (m, 2 H), 0.87-0.95 (m, 2 H), 0.78-0.85 (m, 2 H), 0.61-0.70 (m, 2 H) 402.2 [M+H] + 99.7%
2227 (CD 3OD) δ 8.16 (d, 1 H), 7.55 (s, 1 H), 6.62-6.73 (m, 2 H), 6.56 (s, 1 H), 6.13 (br s, 1 H), 4.07 (dd, 1 H), 3.59 (ddd, 1 H), 2.84-2.96 (m, 1 H), 2.68 (br dd, 1 H), 1.92-2.03 (m, 1 H), 1.38 (s, 3 H), 1.12-1.19 (m, 2 H), 0.89-0.95 (m, 2 H), 0.80-0.85 (m, 2 H), 0.62-0.70 (m, 2 H) 402.2 [M+H] + 99.6%
2228 (CD 3OD) δ 8.18 (d, 1 H), 7.54 (s, 1 H), 6.94 (d, 1 H), 6.72 (t, 1 H), 6.47 (s, 1 H), 6.12 (br s, 1 H), 4.06 (dd, 1 H), 3.59 (ddd, 1 H), 3.02-3.13 (m, 1 H), 2.83-2.97 (m, 1 H), 2.68 (dd, 1 H), 1.38 (s, 3 H), 1.22 (dd, 6 H), 1.12-1.17 (m, 2 H), 0.78-0.86 (m, 2 H) 404.3 [M+H] + 99.8%
2229 (CD 3OD) δ 8.18 (d, 1 H), 7.54 (s, 1 H), 6.94 (d, 1 H), 6.72 (t, 1 H), 6.47 (s, 1 H), 6.12 (s, 1 H), 4.06 (dd, 1 H), 3.53-3.67 (m, 1 H), 3.01-3.14 (m, 1 H), 2.83-2.96 (m, 1 H), 2.68 (dd, 1 H), 1.38 (s, 3 H), 1.22 (dd, 6 H), 1.12-1.18 (m, 2 H), 0.77-0.86 (m, 2 H) 404.3 [M+H] + 99.3%
2230 (CD 3OD) δ 8.31 (d, 1 H), 7.62-7.73 (m, 1 H), 7.07 (d, 1 H), 6.81-6.90 (m, 1 H), 6.66 (s, 1 H), 6.38 (s, 1 H), 4.32 (dd, 1 H), 3.79 (ddd, 1 H), 3.20 (dt, 1 H), 3.01-3.12 (m, 1 H), 2.84 (dd, 1 H), 2.12 (t, 3 H), 1.32-1.37 (m, 6 H) 414.2 [M+H] + 100%
2231 (CD 3OD) δ 8.31 (d, 1 H), 7.68 (s, 1 H), 7.07 (d, 1 H), 6.85 (t, 1 H), 6.66 (s, 1 H), 6.32-6.44 (m, 1 H), 4.32 (dd, 1 H), 3.79 (ddd, 1 H), 3.20 (dt, 1 H), 3.01-3.12 (m, 1 H), 2.84 (br dd, 1 H), 2.12 (t, 3 H), 1.35 (dd, 6 H) 414.2 [M+H] + 99.4%
2232 (CD 3OD) δ 8.33 (d, 1 H), 7.58 (s, 1 H), 7.18 (d, 1 H), 6.74 (t, 1 H), 6.59 (s, 1 H), 6.27 (s, 1 H), 4.21 (dd, 1 H), 3.65 (ddd, 1 H), 2.89-3.01 (m, 1 H), 2.72 (dd, 1 H), 2.00 (t, 3 H) 406.1 [M+H] + 100%
2233 (CD 3OD) δ 8.33 (d, 1 H), 7.57 (s, 1 H), 7.19 (d, 1 H), 6.74 (t, 1 H), 6.59 (s, 1 H), 6.26 (br s, 1 H), 4.21 (dd, 1 H), 3.65 (ddd, 1 H), 2.89-3.00 (m, 1 H), 2.72 (br dd, 1 H), 2.00 (t, 3 H) 406.1 [M+H] + 99.9%
2234 (CD 3OD) δ 8.54 (dd, 1 H), 8.24-8.43 (m, 2 H), 7.72 (s, 1 H), 7.45 (dd, 1 H), 7.06 (d, 1 H), 6.84 (t, 1 H), 6.68 (s, 1 H), 6.46 (s, 1 H), 4.40 (dd, 1 H), 3.74-3.92 (m, 1 H), 3.03-3.28 (m, 2 H), 2.78-2.95 (m, 4 H), 1.34 (dd, 6 H) 441.2 [M+H] + 100%
2235 (CD 3OD) δ 8.54 (dd, 1 H), 8.24-8.41 (m, 2 H), 7.70 (s, 1 H), 7.45 (dd, 1 H), 7.05 (d, 1 H), 6.83 (t, 1 H), 6.68 (s, 1 H), 6.46 (s, 1 H), 4.40 (dd, 1 H), 3.71-3.91 (m, 1 H), 3.01-3.28 (m, 2 H), 2.88 (s, 4 H), 1.33 (dd, 6 H) 441.2 [M+H] + 99.8%
2236 (CD 3OD) δ 8.26-8.61 (m, 3 H), 7.70 (s, 1 H), 7.45 (dd, 1 H), 7.29 (d, 1 H), 6.66-6.90 (m, 2 H), 6.46 (s, 1 H), 4.41 (dd, 1 H), 3.81 (br dd, 1 H), 3.02-3.20 (m, 1 H), 2.76-3.00 (m, 4 H) 433.1 [M+H] + 100%
2237 (CD 3OD) δ 8.11-8.50 (m, 3 H), 7.58 (s, 1 H), 7.11-7.41 (m, 2 H), 6.54-6.79 (m, 2 H), 6.34 (s, 1 H), 4.29 (dd, 1 H), 3.54-3.81 (m, 1 H), 2.99 (br s, 1 H), 2.61-2.85 (m, 4 H) 433.2 [M+H] + 99.6%
2238 (CD 3OD) δ 8.42 (d, 1 H), 7.60 (s, 1 H), 7.51 (d, 1 H), 7.06-7.23 (m, 5 H), 6.74-6.84 (m, 2 H), 6.35 (s, 1 H), 6.00 (s, 1 H), 3.84-3.92 (m, 1 H), 3.53-3.68 (m, 1 H), 2.87-2.98 (m, 1 H), 2.67 (br dd, 1 H) 316.1 [M+H] + 100%
2239 (CD 3OD) δ 8.42 (d, 1 H), 7.85 (s, 1 H), 7.52 (d, 1 H), 7.06-7.25 (m, 5 H), 6.74-6.87 (m, 2 H), 6.37 (s, 1 H), 6.04 (s, 1 H), 3.78-3.97 (m, 1 H), 3.50-3.69 (m, 1 H), 2.94 (ddd, 1 H), 2.69 (br dd, 1 H) 316.1 [M+H] + 99.4%
2240 (CD 3OD) δ 9.33-9.50 (m, 1 H), 8.70-8.89 (m, 2 H), 7.93-8.51 (m, 2 H), 7.64-7.88 (m, 1 H), 6.59-7.13 (m, 4 H), 4.64 (br s, 1 H), 3.46-3.93 (m, 1 H), 2.97-3.22 (m, 1 H), 2.89 (br d, 1 H), 2.48 (s, 3 H) 427.2 [M+H] + 100%
2241 (CD 3OD) δ 9.42 (s, 1 H), 8.72-8.86 (m, 2 H), 7.92-8.49 (m, 2 H), 7.70 (br s, 1 H), 6.64-7.07 (m, 4 H), 4.79 (br s, 0.5 H), 4.56-4.63 (m, 0.5 H), 3.43-3.93 (m, 1 H), 2.96-3.29 (m, 1 H), 2.77-2.93 (m, 1 H), 2.48 (s, 3 H) 427.2 [M+H] + 100%
2242 (CD 3OD) δ 9.42 (s, 1 H), 8.73-8.82 (m, 2 H), 8.51-8.72 (m, 1 H), 7.92-8.33 (m, 1 H), 7.71 (br s, 1 H), 7.46 (br d, 1 H), 6.69-7.20 (m, 4 H), 4.60-4.83 (m, 1 H), 3.42-3.93 (m, 1 H), 2.99-3.25 (m, 1 H), 2.89 (br s, 1 H) 463.1 [M+H] + 100%
2243 (CD 3OD) δ 9.42 (s, 1 H), 8.72-8.85 (m, 2 H), 8.54-8.71 (m, 1 H), 7.91-8.30 (m, 1 H), 7.71 (br s, 1 H), 7.46 (br d, 1 H), 6.72-7.19 (m, 4 H), 4.65-4.80 (m, 1 H), 3.44-3.92 (m, 1 H), 3.04 (br s, 1 H), 2.86 (br s, 1 H) 463.2 [M+H] + 96.3%
2244 (CD 3OD) δ 9.42 (s, 1 H), 8.78 (s, 3 H), 7.91-8.27 (m, 1 H), 7.59-7.79 (m, 2 H), 6.71-7.18 (m, 3 H), 4.65-4.80 (m, 1 H), 3.42-3.92 (m, 1 H), 2.97-3.22 (m, 1 H), 2.88 (br s, 1 H) 481.2 [M+H] + 99.6%
2245 (CD 3OD) δ 9.42 (s, 1 H), 8.78 (s, 3 H), 7.93-8.30 (m, 1 H), 7.57-7.80 (m, 2 H), 6.72-7.17 (m, 3 H), 4.82 (br s, 1 H), 3.43-3.93 (m, 1 H), 2.98-3.28 (m, 1 H), 2.88 (br s, 1 H) 481.2 [M+H] + 95.9%
2246 (CD 3OD) δ 8.44 (s, 1 H), 8.08 (d, 1 H), 7.95 (s, 1 H), 7.79 (dd, 1 H), 7.15 (d, 1 H), 7.00 (s, 1 H), 6.78 (t, 1 H), 6.45-6.66 (m, 2 H), 4.70 (br dd, 1 H), 3.95 (s, 3 H), 3.55-3.67 (m, 1 H), 2.89-3.05 (m, 1 H), 2.65-2.84 (m, 1 H) 415.2 [M+H] + 100%
2247 (CD 3OD) δ 8.43 (s, 1 H), 8.08 (d, 1 H), 7.69-7.91 (m, 2 H), 7.14 (d, 1 H), 6.96 (s, 1 H), 6.77 (t, 1 H), 6.57 (t, 2 H), 4.70 (br dd, 1 H), 3.95 (s, 3 H), 3.52-3.69 (m, 1 H), 2.89-3.05 (m, 1 H), 2.65-2.83 (m, 1 H) 415.2 [M+H] + 96.9%
2248 (CD 3OD) δ 8.49 (d, 1 H), 7.68 (s, 1 H), 7.14-7.27 (m, 1 H), 6.91 (t, 1 H), 6.70 (s, 1 H), 6.31 (s, 1 H), 4.24 (dd, 1 H), 3.70 (ddd, 1 H), 2.99-3.11 (m, 1 H), 2.80 (dd, 1 H), 2.44 (s, 3 H) 406.1 [M+H] + 100%
2249 (CD 3OD) δ 8.49 (d, 1 H), 7.68 (s, 1 H), 7.21 (br d, 1 H), 6.91 (t, 1 H), 6.70 (s, 1 H), 6.31 (br s, 1 H), 4.24 (dd, 1 H), 3.64-3.78 (m, 1 H), 2.97-3.11 (m, 1 H), 2.80 (br dd, 1 H), 2.44 (s, 3 H) 406.1 [M+H] + 96.1%
2250 (CD 3OD) δ 8.37 (d, 1 H), 7.58 (s, 1 H), 7.09 (d, 1 H), 6.72-7.01 (m, 2 H), 6.62 (s, 1 H), 6.28 (s, 1 H), 4.23 (dd, 1 H), 3.66 (ddd, 1 H), 2.85-3.03 (m, 1 H), 2.73 (dd, 1 H) 442.1 [M+H] + 99.6%
2251 (CD 3OD) δ 8.37 (d, 1 H), 7.57 (s, 1 H), 7.09 (br d, 1 H), 6.73-7.00 (m, 2 H), 6.62 (s, 1 H), 6.28 (br s, 1 H), 4.23 (dd, 1 H), 3.60-3.73 (m, 1 H), 2.88-3.02 (m, 1 H), 2.73 (br dd, 1 H) 442.1 [M+H] + 98.9%
2252 (CD 3OD) δ 8.38 (d, 1 H), 7.61 (s, 1 H), 7.10 (d, 1 H), 6.80 (t, 1 H), 6.63 (s, 1 H), 6.30 (s, 1 H), 4.25 (dd, 1 H), 3.67 (ddd, 1 H), 2.91-3.03 (m, 1 H), 2.74 (dd, 1 H) 460.1 [M+H] + 99.6%
2253 (CD 3OD) δ 8.50 (d, 1 H), 7.71 (s, 1 H), 7.22 (d, 1 H), 6.93 (t, 1 H), 6.75 (s, 1 H), 6.42 (s, 1 H), 4.37 (dd, 1 H), 3.80 (td, 1 H), 3.03-3.14 (m, 1 H), 2.86 (dd, 1 H) 460.1 [M+H] + 96.9%
2254 (CD 3OD) δ 8.07-8.59 (m, 3 H), 7.65 (s, 1 H), 6.95-7.28 (m, 2 H), 6.77-6.95 (m, 2 H), 6.55-6.72 (m, 2 H), 5.06 (dd, 1 H), 3.38-3.57 (m, 1 H), 2.82-2.99 (m, 1 H), 2.70 (br dd, 1 H) 384.2 [M+H] + 99.5%
2255 (CD 3OD) δ 8.22-8.50 (m, 3 H), 7.65 (s, 1 H), 6.96-7.28 (m, 2 H), 6.76-6.96 (m, 2 H), 6.58-6.71 (m, 2 H), 5.06 (dd, 1 H), 3.46 (ddd, 1 H), 2.82-2.98 (m, 1 H), 2.70 (br dd, 1 H) 384.2 [M+H] + 98.7%
2256 (CD 3OD) δ 8.68 (s, 2 H), 8.33 (d, 1 H), 7.67 (s, 1 H), 6.96-7.32 (m, 2 H), 6.79-6.96 (m, 2 H), 6.68 (s, 1 H), 5.20 (dd, 1 H), 3.53 (td, 1 H), 2.64-3.05 (m, 2 H) 452.1 [M+H] + 99.2%
2257 (CD 3OD) δ 8.68 (s, 2 H), 8.33 (d, 1 H), 7.67 (s, 1 H), 6.98-7.30 (m, 2 H), 6.78-6.97 (m, 2 H), 6.68 (s, 1 H), 5.20 (dd, 1 H), 3.40-3.64 (m, 1 H), 2.51-3.02 (m, 2 H) 452.1 [M+H] + 98.2%
2258 (CD 3OD) δ 8.33 (d, 1 H), 7.56 (s, 1 H), 7.18 (d, 1 H), 6.73 (t, 1 H), 6.52 (s, 1 H), 6.12 (s, 1 H), 4.08 (dd, 1 H), 3.57 (ddd, 1 H), 2.84-2.97 (m, 1 H), 2.68 (dd, 1 H), 1.38 (s, 3 H), 1.11-1.18 (m, 2 H), 0.78-0.86 (m, 2 H) 396.2 [M+H] + 100%
2259 (CD 3OD) δ 8.33 (d, 1 H), 7.55 (s, 1 H), 7.18 (d, 1 H), 6.73 (t, 1 H), 6.52 (s, 1 H), 6.12 (s, 1 H), 4.08 (dd, 1 H), 3.57 (ddd, 1 H), 2.84-2.95 (m, 1 H), 2.68 (dd, 1 H), 1.38 (s, 3 H), 1.10-1.17 (m, 2 H), 0.79-0.85 (m, 2 H) 396.2 [M+H] + 99.4%
2260 (CD 3OD) δ 9.16 (d, 1 H), 8.69 (dd, 1 H), 8.40 (br d, 1 H), 8.31 (br d, 1 H), 7.70 (s, 1 H), 7.61 (dd, 1 H), 7.06 (br d, 1 H), 6.84 (t, 1 H), 6.69 (s, 1 H), 6.42-6.53 (m, 1 H), 4.41 (dd, 1 H), 3.76-3.90 (m, 1 H), 3.04-3.25 (m, 2 H), 2.87 (br dd, 1 H), 1.33 (t, 6 H) 427.2 [M+H] + 99.0%
2261 (CD 3OD) δ 9.16 (d, 1 H), 8.64-8.74 (m, 1 H), 8.40 (br d, 1 H), 8.31 (d, 1 H), 7.72 (s, 1 H), 7.61 (dd, 1 H), 7.06 (d, 1 H), 6.84 (t, 1 H), 6.69 (s, 1 H), 6.49 (s, 1 H), 4.42 (dd, 1 H), 3.74-3.91 (m, 1 H), 3.01-3.25 (m, 2 H), 2.87 (br dd, 1 H), 1.33 (t, 6 H) 427.2 [M+H] + 97.3%
2262 (CD 3OD) δ 9.15 (s, 1 H), 8.69 (br d, 1 H), 8.45 (br d, 1 H), 8.39 (br dd, 1 H), 7.71 (s, 1 H), 7.56-7.64 (m, 1 H), 7.29 (dd, 1 H), 6.79-6.88 (m, 1 H), 6.73 (s, 1 H), 6.49 (s, 1 H), 4.43 (dd, 1 H), 3.81 (ddd, 1 H), 3.05-3.18 (m, 1 H), 2.87 (dd, 1 H) 419.1 [M+H] + 100%
2263 (CD 3OD) δ 9.15 (d, 1 H), 8.69 (dd, 1 H), 8.45 (d, 1 H), 8.39 (dt, 1 H), 7.70 (s, 1 H), 7.61 (dd, 1 H), 7.30 (d, 1 H), 6.85 (t, 1 H), 6.73 (s, 1 H), 6.49 (s, 1 H), 4.43 (dd, 1 H), 3.74-3.86 (m, 1 H), 3.05-3.18 (m, 1 H), 2.87 (dd, 1 H) 419.1 [M+H] + 99.7%
2264 (CD 3OD) δ 8.48-8.57 (m, 1 H), 8.28 (s, 2 H), 7.73 (s, 1 H), 7.43-7.56 (m, 1 H), 7.00 (d, 1 H), 6.79 (t, 1 H), 6.62 (s, 1 H), 6.47 (s, 1 H), 4.40 (dd, 1 H), 3.66-3.95 (m, 1 H), 3.01-3.20 (m, 1 H), 2.79-2.95 (m, 1 H), 2.45 (s, 3 H) 417.2 [M+H] + 100%
2265 (CD 3OD) δ 8.45-8.61 (m, 1 H), 8.24-8.41 (m, 2 H), 7.75 (br s, 1 H), 7.44-7.56 (m, 1 H), 6.99 (d, 1 H), 6.79 (t, 1 H), 6.62 (s, 1 H), 6.47 (s, 1 H), 4.40 (dd, 1 H), 3.70-3.90 (m, 1 H), 3.04-3.22 (m, 1 H), 2.87 (br dd, 1 H), 2.44 (s, 3 H) 417.2 [M+H] + 99.3%
2266 (CD 3OD) δ 8.51 (br d, 1 H), 8.41 (d, 1 H), 7.82 (br d, 1 H), 7.67 (s, 1 H), 7.55 (d, 1 H), 7.42 (dd, 1 H), 7.15 (t, 1 H), 6.76-6.87 (m, 1 H), 6.62 (s, 1 H), 6.54 (s, 1 H), 4.44 (dd, 1 H), 3.77 (ddd, 1 H), 3.01-3.15 (m, 1 H), 2.82 (dd, 1 H), 2.68 (s, 3 H) 399.2 [M+H] + 99.7%
2267 (CD 3OD) δ 8.52 (br d, 1 H), 8.42 (br d, 1 H), 7.83 (br d, 1 H), 7.67 (s, 1 H), 7.56 (br d, 1 H), 7.43 (dd, 1 H), 7.16 (br t, 1 H), 6.78-6.88 (m, 1 H), 6.63 (s, 1 H), 6.54 (s, 1 H), 4.44 (dd, 1 H), 3.78 (ddd, 1 H), 3.02-3.15 (m, 1 H), 2.78-2.85 (m, 1 H), 2.68 (s, 3 H) 399.2 [M+H] + 99.0%
2268 (CD 3OD) δ 8.54 (d, 1 H), 8.29 (d, 1 H), 7.86 (d, 1 H), 7.67 (s, 1 H), 7.45 (dd, 1 H), 6.97 (d, 1 H), 6.76 (t, 1 H), 6.53-6.67 (m, 2 H), 4.45 (dd, 1 H), 3.79 (ddd, 1 H), 3.04-3.15 (m, 1 H), 2.83 (br dd, 1 H), 2.70 (s, 3 H), 2.43 (s, 3 H) 413.2 [M+H] + 99.9%
2269 (CD 3OD) δ 8.53 (d, 1 H), 8.29 (d, 1 H), 7.85 (d, 1 H), 7.67 (s, 1 H), 7.45 (dd, 1 H), 6.97 (d, 1 H), 6.76 (t, 1 H), 6.65 (s, 1 H), 6.55 (br s, 1 H), 4.45 (dd, 1 H), 3.74-3.84 (m, 1 H), 3.02-3.16 (m, 1 H), 2.83 (br dd, 1 H), 2.70 (s, 3 H), 2.43 (s, 3 H) 413.2 [M+H] + 98.8%
2270 (CD 3OD) δ 8.44-8.47 (m, 1 H), 8.41 (d, 2 H), 7.65 (s, 1 H), 7.13-7.22 (m, 2 H), 6.86 (t, 1 H), 6.61-6.70 (m, 2 H), 5.07 (dd, 1 H), 3.39-3.51 (m, 1 H), 2.85-2.96 (m, 1 H), 2.71 (dd, 1 H) 402.2 [M+H] + 99.6%
2271 (CD 3OD) δ 8.46 (d, 1 H), 8.41 (d, 2 H), 7.65 (s, 1 H), 7.15-7.21 (m, 2 H), 6.87 (t, 1 H), 6.64-6.69 (m, 2 H), 5.07 (dd, 1 H), 3.41-3.51 (m, 1 H), 2.85-2.97 (m, 1 H), 2.71 (dd, 1 H) 402.1 [M+H] + 98.9%
2272 (CD 3OD) δ 8.28-8.49 (m, 2 H), 7.77 (dd, 1 H), 7.65 (s, 1 H), 6.98-7.23 (m, 2 H), 6.73-6.98 (m, 3 H), 6.64 (s, 1 H), 4.73 (br dd, 1 H), 3.52-3.72 (m, 1 H), 2.88-3.04 (m, 1 H), 2.74 (br dd, 1 H) 415.2 [M+H] + 99.1%
2273 (CD 3OD) δ 8.22-8.53 (m, 2 H), 7.77 (dd, 1 H), 7.65 (s, 1 H), 7.00-7.25 (m, 2 H), 6.79-6.97 (m, 3 H), 6.64 (s, 1 H), 4.73 (br dd, 1 H), 3.61 (ddd, 1 H), 2.87-3.03 (m, 1 H), 2.74 (dd, 1 H) 415.2 [M+H] + 92.9%
2274 (CD 3OD) δ 8.49-8.57 (m, 1 H), 8.37 (d, 1 H), 7.68 (s, 1 H), 7.45-7.54 (m, 2 H), 7.12 (dd, 1 H), 6.72 (d, 1 H), 6.43-6.59 (m, 2 H), 4.40 (dd, 1 H), 3.78-3.94 (m, 1 H), 3.05-3.16 (m, 1 H), 2.87 (br dd, 1 H), 2.64 (s, 3 H) 417.2 [M+H] + 100%
2275 (CD 3OD) δ 8.52 (ddd, 1 H), 8.37 (d, 1 H), 7.68 (s, 1 H), 7.42-7.54 (m, 2 H), 7.12 (dd, 1 H), 6.72 (d, 1 H), 6.43-6.59 (m, 2 H), 4.40 (dd, 1 H), 3.87 (ddd, 1 H), 3.03-3.19 (m, 1 H), 2.86 (br dd, 1 H), 2.64 (s, 3 H) 417.2 [M+H] + 98.4%
2276 (CD 3OD) δ 8.68 (d, 1 H), 8.51-8.55 (m, 1 H), 7.85 (d, 1 H), 7.69 (s, 1 H), 7.60 (d, 1 H), 7.45 (dd, 1 H), 6.96 (t, 1 H), 6.84 (s, 1 H), 6.58 (s, 1 H), 4.49 (dd, 1 H), 3.80 (ddd, 1 H), 3.04-3.16 (m, 1 H), 2.84 (dd, 1 H), 2.70 (s, 3 H) 467.2 [M+H] + 100%
2277 (CD 3OD) δ 8.68 (d, 1 H), 8.53 (d, 1 H), 7.85 (d, 1 H), 7.68 (s, 1 H), 7.61 (d, 1 H), 7.45 (dd, 1 H), 6.96 (t, 1 H), 6.84 (s, 1 H), 6.58 (s, 1 H), 4.49 (dd, 1 H), 3.74-3.85 (m, 1 H), 3.05-3.16 (m, 1 H), 2.84 (br dd, 1 H), 2.70 (s, 3 H) 467.2 [M+H] + 98.7%
2278 (CD 3OD) δ 8.51-8.62 (m, 2 H), 7.86 (d, 1 H), 7.68 (s, 1 H), 7.39-7.49 (m, 2 H), 6.81-7.12 (m, 3 H), 6.58 (br s, 1 H), 4.47 (dd, 1 H), 3.78 (ddd, 1 H), 3.04-3.15 (m, 1 H), 2.84 (br dd, 1 H), 2.70 (s, 3 H) 449.2 [M+H] + 98.6%
2279 (CD 3OD) δ 8.50-8.63 (m, 2 H), 7.86 (d, 1 H), 7.68 (s, 1 H), 7.39-7.49 (m, 2 H), 6.79-7.15 (m, 3 H), 6.58 (s, 1 H), 4.47 (dd, 1 H), 3.78 (ddd, 1 H), 3.05-3.15 (m, 1 H), 2.84 (dd, 1 H), 2.70 (s, 3 H) 449.2 [M+H] + 96.9%
2280 (CD 3OD) δ 8.54 (dd, 1 H), 8.34 (d, 1 H), 7.86 (d, 1 H), 7.70 (s, 1 H), 7.46 (dd, 1 H), 6.95 (dd, 1 H), 6.76-6.88 (m, 2 H), 6.56 (s, 1 H), 4.48 (dd, 1 H), 3.75-3.85 (m, 1 H), 3.05-3.15 (m, 1 H), 2.84 (br dd, 1 H), 2.71 (s, 3 H) 471.2 [M+H] + 98.2%
2281 (CD 3OD) δ 8.53 (d, 1 H), 8.33 (d, 1 H), 7.86 (d, 1 H), 7.70 (s, 1 H), 7.45 (dd, 1 H), 6.95 (dd, 1 H), 6.76-6.85 (m, 2 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.75-3.85 (m, 1 H), 3.05-3.16 (m, 1 H), 2.84 (dd, 1 H), 2.70 (s, 3 H) 417.2 [M+H] + 99.6%
2282 (CD 3OD) δ 8.53 (d, 1 H), 8.26 (d, 1 H), 7.85 (d, 1 H), 7.68 (s, 1 H), 7.44 (dd, 1 H), 6.71-6.84 (m, 3 H), 6.56 (s, 1 H), 4.46 (dd, 1 H), 3.73-3.87 (m, 1 H), 3.03-3.18 (m, 1 H), 2.83 (dd, 1 H), 2.70 (s, 3 H), 2.03-2.13 (m, 1 H), 0.96-1.05 (m, 2 H), 0.71-0.80 (m, 2 H) 439.2 [M+H] + 100%
2283 (CD 3OD) δ 8.54 (d, 1 H), 8.26 (d, 1 H), 7.85 (d, 1 H), 7.76 (s, 1 H), 7.45 (dd, 1 H), 6.72-6.85 (m, 3 H), 6.58 (s, 1 H), 4.46 (dd, 1 H), 3.80 (ddd, 1 H), 3.00-3.16 (m, 1 H), 2.84 (dd, 1 H), 2.70 (s, 3 H), 2.04-2.14 (m, 1 H), 0.97-1.06 (m, 2 H), 0.72-0.80 (m, 2 H) 439.2 [M+H] + 92.5%
2284 (CD 3OD) δ 8.53 (br d, 1 H), 8.23-8.31 (m, 1 H), 7.64-7.88 (m, 2 H), 7.36-7.49 (m, 1 H), 6.98-7.07 (m, 1 H), 6.72-6.84 (m, 2 H), 6.55 (s, 1 H), 4.45 (br dd, 1 H), 3.80 (td, 1 H), 3.04-3.22 (m, 2 H), 2.83 (br dd, 1 H), 2.63-2.72 (m, 3 H), 1.23-1.36 (m, 6 H) 441.2 [M+H] + 100%
2285 (CD 3OD) δ 8.53 (d, 1 H), 8.28 (d, 1 H), 7.84 (d, 1 H), 7.67 (s, 1 H), 7.44 (dd, 1 H), 7.02 (d, 1 H), 6.73-6.83 (m, 2 H), 6.55 (s, 1 H), 4.45 (dd, 1 H), 3.80 (ddd, 1 H), 3.04-3.22 (m, 2 H), 2.83 (dd, 1 H), 2.69 (s, 3 H), 1.31 (t, 6 H) 441.2 [M+H] + 98.4%
2286 1H (甲醇- d 4) δ 8.52 (d, 1 H), 8.42 (d, 1 H), 7.84 (br d, 1 H), 7.68 (s, 1 H), 7.43 (dd, 1 H), 7.26 (d, 1 H), 6.74-6.85 (m, 2 H), 6.55 (s, 1 H), 4.47 (dd, 1 H), 3.79 (ddd, 1 H), 3.04-3.14 (m, 1 H), 2.83 (dd, 1 H), 2.69 (s, 3 H) 433.1 [M+H] + 100%
2287 (CD 3OD) δ 8.51 (br d, 1 H), 8.40 (d, 1 H), 7.82 (br d, 1 H), 7.68 (s, 1 H), 7.42 (dd, 1 H), 7.24 (d, 1 H), 6.74-6.83 (m, 2 H), 6.55 (s, 1 H), 4.47 (br dd, 1 H), 3.73-3.84 (m, 1 H), 3.01-3.15 (m, 1 H), 2.63-2.73 (m, 1 H), 2.68 (s, 3 H) 433.1 [M+H] + 99.1%
2288 (CD 3OD) δ 8.54-8.60 (m, 1 H), 8.31-8.37 (m, 1 H), 7.86 (ddd, 1 H), 7.68-7.71 (m, 1 H), 7.63 (dt, 1 H), 6.96 (dd, 1 H), 6.80-6.86 (m, 1 H), 6.78-6.80 (m, 1 H), 6.54 (s, 1 H), 4.47 (dd, 1 H), 3.78-3.86 (m, 1 H), 3.06-3.16 (m, 1 H), 2.86 (br dd, 1 H) 421.1 [M+H] + 100%
2289 (CD 3OD) δ 8.57 (d, 1 H), 8.30-8.39 (m, 1 H), 7.80-7.92 (m, 1 H), 7.72 (s, 1 H), 7.64 (dt, 1 H), 6.96 (dd, 1 H), 6.81-6.86 (m, 1 H), 6.78-6.80 (m, 1 H), 6.54 (s, 1 H), 4.47 (dd, 1 H), 3.77-3.88 (m, 1 H), 3.06-3.17 (m, 1 H), 2.86 (dd, 1 H) 421.1 [M+H] + 99.0%
2290 (CD 3OD) δ 8.10-8.24 (m, 1 H), 7.60 (s, 1 H), 7.40 (s, 0.3 H), 6.81-6.96 (m, 1.7 H), 6.61-6.71 (m, 2 H), 6.42-6.58 (m, 1 H), 4.89 (br dd, 1 H), 3.62-3.73 (m, 0.7 H), 3.31 (td, 0.3 H), 2.84-3.14 (m, 1 H), 2.73 (br dd, 1 H), 2.25-2.38 (m, 6 H) 430.2 [M+H] + 100%
2291 (CD 3OD) δ 8.10-8.24 (m, 1 H), 7.61 (s, 1 H), 7.41 (s, 0.3 H), 6.82-6.92 (m, 1.7 H), 6.60-6.72 (m, 2 H), 6.44-6.57 (m, 1 H), 4.89 (br dd, 1 H), 3.62-3.72 (m, 0.7 H), 3.31 (td, 0.3 H), 2.84-3.15 (m, 1 H), 2.69-2.78 (m, 1 H), 2.26-2.37 (m, 6 H) 430.2 [M+H] + 98.8%
2292 (CD 3OD) δ 8.11-8.25 (m, 1 H), 7.64 (d, 1 H), 7.57 (s, 1 H), 7.33-7.43 (m, 0.3 H), 6.83-6.93 (m, 1.7 H), 6.62-6.72 (m, 1 H), 6.47-6.58 (m, 1 H), 4.82-4.95 (m, 1H), 3.60-3.79 (m, 0.7 H), 3.27-3.39 (m, 0.3 H), 3.04-3.15 (m, 0.7 H), 2.86-2.96 (m, 0.3 H), 2.68-2.80 (m, 1 H), 2.28-2.37 (m, 6 H) 430.2 [M+H] + 100%
2293 (CD 3OD) δ 8.12-8.24 (m, 1 H), 7.59 (d, 2 H), 7.38 (s, 0.3 H), 6.83-6.93 (m, 1.7 H), 6.62-6.72 (m, 1 H), 6.45 (s, 1 H), 4.82-4.94 (m, 1 H), 3.62-3.75 (m, 0.7 H), 3.27-3.39 (m, 0.3 H), 3.03-3.14 (m, 0.7 H), 2.84-2.97 (m, 0.3 H), 2.68-2.77 (m, 1 H), 2.27-2.40 (m, 6 H) 430.2 [M+H] + 96.9%
2294 (CD 3OD) δ 8.13-8.27 (m, 1 H), 7.60 (s, 1 H), 7.41 (s, 0.3 H), 6.79-6.93 (m, 1.7 H), 6.59-6.78 (m, 3 H), 4.83-4.97 (m, 1 H), 3.61-3.73 (m, 0.7 H), 3.29 (td, 0.3 H), 2.82-3.13 (m, 1 H), 2.74 (br dd, 1 H), 2.29 (s, 3 H) 434.1 [M+H] + 99.2%
2295 (CD 3OD) δ 8.15-8.28 (m, 1 H), 7.63 (s, 1 H), 7.42 (s, 0.3 H), 6.79-6.90 (m, 1.7 H), 6.59-6.77 (m, 3 H), 4.92 (br dd, 1 H), 3.60-3.72 (m, 0.7 H), 3.29 (td, 0.3 H), 2.83-3.15 (m, 1 H), 2.68-2.79 (m, 1 H), 2.29 (s, 3 H) 434.2 [M+H] + 96.8%
2296 (CD 3OD) δ 8.15-8.30 (m, 1 H), 7.54-7.65 (m, 2 H), 7.36 (s, 0.3 H), 6.80-6.92 (m, 1.7 H), 6.61-6.78 (m, 2 H), 4.83-4.96 (m, 1 H), 3.61-3.75 (m, 0.7 H), 3.30 (td, 0.3 H), 3.02-3.15 (m, 0.7 H), 2.86-2.95 (m, 0.3 H), 2.69 (d, 1 H), 2.28-2.34 (m, 3 H) 434.2 [M+H] + 100%
2297 (CD 3OD) δ 8.17-8.28 (m, 1 H), 7.53-7.67 (m, 2 H), 7.40 (s, 0.3 H), 6.80-6.91 (m, 1.7 H), 6.61-6.77 (m, 2 H), 4.84-4.96 (m, 1 H), 3.68 (ddd, 0.7 H), 3.30 (td, 0.3 H), 3.02-3.14 (m, 0.7 H), 2.84-2.96 (m, 0.3 H), 2.68-2.80 (m, 1 H), 2.26-2.37 (m, 3 H) 434.2 [M+H] + 98.2%
2298 (CD 3OD) δ 8.39 (d, 2 H), 8.04 (d, 1 H), 7.61 (s, 1 H), 7.15 (s, 1 H), 6.73 (t, 1 H), 6.63 (t, 1 H), 6.46-6.57 (m, 2 H), 5.01 (dd, 1 H), 3.93 (s, 3 H), 3.36-3.49 (m, 1 H), 2.78-2.95 (m, 1 H), 2.68 (dd, 1 H) 348.1 [M+H] + 99.8%
2299 (CD 3OD) δ 8.40 (d, 2 H), 8.05 (d, 1 H), 7.63 (s, 1 H), 7.17 (s, 1 H), 6.75 (t, 1 H), 6.64 (t, 1 H), 6.51-6.58 (m, 2 H), 5.03 (dd, 1 H), 3.94 (s, 3 H), 3.37-3.49 (m, 1 H), 2.83-2.95 (m, 1 H), 2.69 (dd, 1 H) 348.1 [M+H] + 98.7%
2300 (CD 3OD) δ 8.43 (d, 1 H), 7.65 (s, 1 H), 7.57 (d, 1 H), 7.12-7.22 (m, 1 H), 6.85 (td, 1 H), 6.52 (s, 1 H), 6.27 (s, 1 H), 4.20 (dd, 1 H), 3.68 (ddd, 1 H), 2.94-3.15 (m, 2 H), 2.78 (dd, 1 H), 1.35 (d, 6 H) 350.2 [M+H] + 99.9%
2301 (CD 3OD) δ 8.43 (d, 1 H), 7.65 (s, 1 H), 7.57 (d, 1 H), 7.14-7.25 (m, 1 H), 6.85 (td, 1 H), 6.52 (s, 1 H), 6.27 (s, 1 H), 4.20 (dd, 1 H), 3.68 (ddd, 1 H), 2.95-3.19 (m, 2 H), 2.78 (dd, 1 H), 1.35 (d, 6 H) 350.2 [M+H] + 99.6%
2302 (CD 3OD) δ 8.28 (d, 1 H), 7.66 (s, 1 H), 6.97 (d, 1 H), 6.77 (t, 1 H), 6.52 (s, 1 H), 6.28 (s, 1 H), 4.20 (dd, 1 H), 3.69 (ddd, 1 H), 2.94-3.19 (m, 2 H), 2.78 (dd, 1 H), 2.42 (s, 3 H), 1.35 (dd, 6 H) 364.2 [M+H] + 98.6%
2303 (CD 3OD) δ 8.28 (d, 1 H), 7.65 (s, 1 H), 6.98 (d, 1 H), 6.77 (t, 1 H), 6.52 (s, 1 H), 6.27 (br s, 1 H), 4.20 (dd, 1 H), 3.69 (ddd, 1 H), 2.95-3.18 (m, 2 H), 2.79 (br dd, 1 H), 2.43 (s, 3 H), 1.35 (dd, 6 H) 364.2 [M+H] + 99.6%
2304 (CD 3OD) δ 8.70 (d, 1 H), 7.70 (s, 1 H), 7.64 (d, 1 H), 7.00 (t, 1 H), 6.73 (s, 1 H), 6.33 (s, 1 H), 4.26 (dd, 1 H), 3.72 (ddd, 1 H), 2.98-3.19 (m, 2 H), 2.82 (dd, 1 H), 1.37 (d, 6 H) 418.2 [M+H] + 99.9%
2305 (CD 3OD) δ 8.67 (d, 1 H), 7.66 (s, 1 H), 7.62 (d, 1 H), 6.98 (t, 1 H), 6.71 (s, 1 H), 6.31 (s, 1 H), 4.24 (dd, 1 H), 3.64-3.77 (m, 1 H), 2.95-3.17 (m, 2 H), 2.80 (dd, 1 H), 1.35 (d, 6 H) 418.2 [M+H] + 98.9%
2306 (CD 3OD) δ 8.51 (br d, 1 H), 7.83 (br d, 1 H), 7.67 (s, 1 H), 7.57 (br d, 1 H), 7.42 (dd, 1 H), 7.14 (dd, 1 H), 6.99 (br d, 1 H), 6.76 (s, 1 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.79-3.95 (m, 1 H), 3.03-3.17 (m, 1 H), 2.83 (dd, 1 H), 2.68 (s, 3 H) 433.2 [M+H] + 100%
2307 (CD 3OD) δ 8.51 (br d, 1 H), 7.83 (br d, 1 H), 7.66 (s, 1 H), 7.57 (dd, 1 H), 7.42 (td, 1 H), 7.10-7.17 (m, 1 H), 6.99 (dd, 1 H), 6.76 (s, 1 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.79-3.92 (m, 1 H), 3.02-3.14 (m, 1 H), 2.83 (dd, 1 H), 2.68 (s, 3 H) 433.2 [M+H] + 99.4%
2308 (CD 3OD) δ 8.47-8.54 (m, 1 H), 7.77-7.88 (m, 1 H), 7.66 (s, 1 H), 7.37-7.49 (m, 2 H), 7.01-7.14 (m, 1 H), 6.52-6.71 (m, 3 H), 4.45 (br dd, 1 H), 3.79-3.93 (m, 1 H), 2.99-3.16 (m, 1 H), 2.83 (br dd, 1 H), 2.56-2.72 (m, 6 H) 413.2 [M+H] + 100%
2309 (CD 3OD) δ 8.52 (d, 1 H), 7.84 (br d, 1 H), 7.66 (s, 1 H), 7.39-7.48 (m, 2 H), 7.09 (dd, 1 H), 6.68 (br d, 1 H), 6.53-6.61 (m, 2 H), 4.45 (dd, 1 H), 3.85 (ddd, 1 H), 3.03-3.15 (m, 1 H), 2.83 (dd, 1 H), 2.58-2.71 (m, 6 H) 413.2 [M+H] + 99.4%
2310 (CD 3OD) δ 8.27 (d, 1 H), 7.58 (s, 1 H), 7.15-7.23 (m, 2 H), 7.09 (d, 2 H), 6.93 (d, 1 H), 6.69-6.80 (m, 2 H), 6.34 (s, 1 H), 5.99 (s, 1 H), 3.88 (br dd, 1 H), 3.60-3.70 (m, 1 H), 2.87-2.98 (m, 1 H), 2.66 (br dd, 1 H), 2.38 (s, 3 H) 330.2 [M+H] + 99.5%
2311 (CD 3OD) δ 8.28 (d, 1 H), 7.60 (s, 1 H), 7.17-7.24 (m, 2 H), 7.09 (d, 2 H), 6.94 (d, 1 H), 6.75 (dt, 2 H), 6.35 (s, 1 H), 6.00 (s, 1 H), 3.89 (br dd, 1 H), 3.60-3.71 (m, 1 H), 2.86-2.99 (m, 1 H), 2.67 (br dd, 1 H), 2.39 (s, 3 H) 330.2 [M+H] + 99.1%
2312 (CD 3OD) δ 8.31 (d, 1 H), 7.60 (s, 1 H), 7.17-7.24 (m, 2 H), 7.09 (d, 2 H), 6.91 (dd, 1 H), 6.74-6.81 (m, 2 H), 6.47 (s, 1 H), 6.02 (s, 1 H), 3.89 (br dd, 1 H), 3.59-3.69 (m, 1 H), 2.93 (tt, 1 H), 2.68 (br dd, 1 H) 334.2 [M+H] + 100%
2313 (CD 3OD) δ 8.31 (d, 1 H), 7.61 (s, 1 H), 7.17-7.24 (m, 2 H), 7.09 (d, 2 H), 6.91 (dd, 1 H), 6.74-6.82 (m, 2 H), 6.47 (s, 1 H), 6.02 (s, 1 H), 3.89 (br dd, 1 H), 3.59-3.68 (m, 1 H), 2.93 (ddd, 1 H), 2.68 (br dd, 1 H) 334.2 [M+H] + 99.7%
2314 (CD 3OD) δ 8.37 (d, 1 H), 7.55 (s, 1 H), 7.09 (br d, 1 H), 6.79 (t, 1 H), 6.56 (s, 1 H), 6.15 (br s, 1 H), 4.09 (dd, 1 H), 3.51-3.63 (m, 1 H), 2.85-2.96 (m, 1 H), 2.68 (br dd, 1 H), 1.92-2.02 (m, 1 H), 0.89-1.07 (m, 4 H) 432.2 [M+H] + 100%
2315 (CD 3OD) δ 8.37 (d, 1 H), 7.56 (s, 1 H), 7.09 (d, 1 H), 6.79 (t, 1 H), 6.56 (s, 1 H), 6.15 (s, 1 H), 4.06-4.13 (m, 1 H), 3.57 (ddd, 1 H), 2.85-2.97 (m, 1 H), 2.63-2.73 (m, 1 H), 1.93-1.99 (m, 1 H), 0.91-1.03 (m, 4 H) 432.2 [M+H] + 97.1%
2316 (CD 3OD) δ 8.56 (s, 2 H), 8.30-8.38 (m, 1 H), 7.56 (s, 1 H), 7.13 (s, 1 H), 7.03-7.09 (m, 1 H), 6.76 (t, 1 H), 6.59 (s, 1 H), 5.09 (dd, 1 H), 3.35-3.48 (m, 1 H), 2.74-2.87 (m, 1 H), 2.65 (dd, 1 H) 470.1 [M+H] + 99.9%
2317 (CD 3OD) δ 8.56 (s, 2 H), 8.34 (d, 1 H), 7.55 (s, 1 H), 7.13 (s, 1 H), 7.06 (br d, 1 H), 6.76 (t, 1 H), 6.59 (s, 1 H), 5.09 (dd, 1 H), 3.42 (td, 1 H), 2.76-2.86 (m, 1 H), 2.62-2.68 (m, 1 H) 470.1 [M+H] + 96.0%
2318 (CD 3OD) δ 8.34 (s, 1 H), 8.23 (br d, 1 H), 7.97-8.12 (m, 1 H), 7.69 (d, 1 H), 7.57 (br s, 1 H), 6.78-7.14 (m, 2 H), 6.68-6.75 (m, 2 H), 6.52 (s, 1 H), 4.59 (br dd, 1 H), 3.42-3.56 (m, 1 H), 2.78-2.92 (m, 1 H), 2.67 (br s, 1 H) 384.1 [M+H] + 99.8%
2319 (CD 3OD) δ 8.34 (d, 1 H), 8.23 (d, 1 H), 8.05 (dd, 1 H), 7.68 (d, 1 H), 7.53 (s, 1 H), 6.79-7.18 (m, 2 H), 6.66-6.76 (m, 2 H), 6.51 (s, 1 H), 4.59 (br dd, 1 H), 3.49 (br dd, 1 H), 2.86 (br s, 1 H), 2.67 (br d, 1 H) 384.1 [M+H] + 96.2%
2320 (CD 3OD) δ 8.57 (br d, 1 H), 7.66 (s, 1 H), 7.42 (br d, 1 H), 6.80-7.14 (m, 2 H), 6.70 (s, 1 H), 6.30 (br s, 1 H), 4.22 (dd, 1 H), 3.61-3.78 (m, 1 H), 2.91-3.18 (m, 2 H), 2.80 (br dd, 1 H), 1.35 (d, 6 H) 400.2 [M+H] + 99.9%
2321 (CD 3OD) δ 8.57 (d, 1 H), 7.66 (s, 1 H), 7.42 (br d, 1 H), 6.80-7.14 (m, 2 H), 6.70 (s, 1 H), 6.30 (s, 1 H), 4.22 (dd, 1 H), 3.69 (ddd, 1 H), 2.97-3.18 (m, 2 H), 2.80 (dd, 1 H), 1.35 (dd, 6 H) 400.2 [M+H] + 99.0%
2322 (CD 3OD) δ 8.32 (d, 1 H), 7.66 (s, 1 H), 6.73-7.04 (m, 2 H), 6.66 (s, 1 H), 6.29 (s, 1 H), 4.22 (dd, 1 H), 3.61-3.79 (m, 1 H), 2.94-3.17 (m, 2 H), 2.79 (br dd, 1 H), 1.35 (d, 6 H) 368.2 [M+H] + 99.9%
2323 (CD 3OD) δ 8.32 (d, 1 H), 7.66 (s, 1 H), 6.77-7.01 (m, 2 H), 6.66 (s, 1 H), 6.29 (s, 1 H), 4.22 (dd, 1 H), 3.70 (td, 1 H), 2.94-3.18 (m, 2 H), 2.79 (br dd, 1 H), 1.35 (d, 6 H) 368.2 [M+H] + 99.3%
2324 (CD 3OD) δ 8.43 (d, 1 H), 7.66 (s, 1 H), 7.29 (d, 1 H), 6.84 (t, 1 H), 6.65 (s, 1 H), 6.28 (br s, 1 H), 4.22 (dd, 1 H), 3.56-3.80 (m, 1 H), 2.93-3.17 (m, 2 H), 2.79 (br dd, 1 H), 1.35 (d, 6 H) 384.2 [M+H] + 100%
2325 (CD 3OD) δ 8.43 (d, 1 H), 7.66 (s, 1 H), 7.29 (d, 1 H), 6.84 (t, 1 H), 6.65 (s, 1 H), 6.28 (br s, 1 H), 4.22 (dd, 1 H), 3.69 (ddd, 1 H), 2.92-3.20 (m, 2 H), 2.79 (br dd, 1 H), 1.35 (d, 6 H) 384.2 [M+H] + 99.2%
2326 (CD 3OD) δ 7.68 (s, 1 H), 7.58-7.65 (m, 1 H), 7.20 (dd, 1 H), 7.06 (d, 1 H), 6.71 (s, 1 H), 6.40 (br s, 1 H), 4.29-4.40 (m, 1 H), 3.76-3.90 (m, 1 H), 2.99-3.15 (m, 1 H), 2.85 (dd, 1 H), 2.12 (t, 3 H) 406.1 [M+H] + 100%
2327 (CD 3OD) δ 7.56 (s, 1 H), 7.49 (dd, 1 H), 7.07 (dd, 1 H), 6.93 (dd, 1 H), 6.58 (s, 1 H), 6.28 (s, 1 H), 4.20 (br d, 1 H), 3.70 (br s, 1 H), 2.88-3.01 (m, 1 H), 2.73 (dd, 1 H), 2.00 (t, 3 H) 406.1 [M+H] + 99.4%
2328 (CD 3OD) δ 7.68 (s, 1 H), 7.48 (d, 1 H), 7.13 (dd, 1 H), 6.73 (d, 1 H), 6.51 (s, 1 H), 6.38 (br s, 1 H), 4.22-4.40 (m, 1 H), 3.71-3.87 (m, 1 H), 2.96-3.13 (m, 1 H), 2.84 (dd, 1 H), 2.65 (s, 3 H), 2.12 (t, 3 H) 386.2 [M+H] + 100%
2329 (CD 3OD) δ 7.56 (s, 1 H), 7.35 (d, 1 H), 7.01 (dd, 1 H), 6.61 (d, 1 H), 6.39 (s, 1 H), 6.26 (s, 1 H), 4.19 (dd, 1 H), 3.67 (td, 1 H), 2.88-3.02 (m, 1 H), 2.72 (dd, 1 H), 2.52 (s, 3 H), 2.00 (t, 3 H) 386.2 [M+H] + 97.7%
2330 (CD 3OD) δ 8.41 (dd, 1 H), 8.25 (dd, 1 H), 7.41-7.61 (m, 2 H), 7.32 (dd, 1 H), 7.05 (dd, 1 H), 6.91 (dd, 1 H), 6.57 (s, 1 H), 6.36 (s, 1 H), 4.28 (dd, 1 H), 3.62-3.81 (m, 1 H), 2.91-3.08 (m, 1 H), 2.68-2.85 (m, 4 H) 433.1 [M+H] + 100%
2331 (CD 3OD) δ 8.41 (dd, 1 H), 8.25 (dd, 1 H), 7.43-7.66 (m, 2 H), 7.32 (dd, 1 H), 7.05 (dd, 1 H), 6.91 (dd, 1 H), 6.57 (s, 1 H), 6.36 (s, 1 H), 4.28 (dd, 1 H), 3.63-3.80 (m, 1 H), 2.88-3.07 (m, 1 H), 2.68-2.84 (m, 4 H) 433.1 [M+H] + 98.2%
2332 (CD 3OD) δ 8.42 (dd, 1 H), 8.23 (dd, 1 H), 7.56 (s, 1 H), 7.24-7.40 (m, 2 H), 6.99 (dd, 1 H), 6.58 (d, 1 H), 6.30-6.45 (m, 2 H), 4.26 (dd, 1 H), 3.64-3.83 (m, 1 H), 2.88-3.07 (m, 1 H), 2.68-2.83 (m, 4 H), 2.50 (s, 3 H) 413.2 [M+H] + 99.9%
2333 (CD 3OD) δ 8.40 (dd, 1 H), 8.21 (dd, 1 H), 7.57 (s, 1 H), 7.23-7.41 (m, 2 H), 6.97 (dd, 1 H), 6.57 (d, 1 H), 6.26-6.46 (m, 2 H), 4.26 (dd, 1 H), 3.62-3.82 (m, 1 H), 2.89-3.04 (m, 1 H), 2.68-2.82 (m, 4 H), 2.49 (s, 3 H) 413.2 [M+H] + 99.2%
2334 (CD 3OD) δ 8.37-8.46 (m, 1 H), 8.23-8.27 (m, 1 H), 8.19 (d, 1 H), 7.58 (s, 1 H), 7.34-7.44 (m, 1 H), 6.94 (d, 1 H), 6.72 (t, 1 H), 6.58 (s, 1 H), 6.35 (s, 1 H), 4.28 (dd, 1 H), 3.64-3.77 (m, 1 H), 2.93-3.14 (m, 2 H), 2.75 (dd, 1 H), 1.22 (dd, 6 H) 445.2 [M+H] + 100%
2335 (CD 3OD) δ 8.36-8.44 (m, 1 H), 8.24 (br d, 1 H), 8.18 (d, 1 H), 7.58 (s, 1 H), 7.38 (br t, 1 H), 6.93 (br d, 1 H), 6.67-6.76 (m, 1 H), 6.58 (s, 1 H), 6.34 (s, 1 H), 4.28 (dd, 1 H), 3.63-3.78 (m, 1 H), 2.92-3.15 (m, 2 H), 2.75 (dd, 1 H), 1.21 (t, 6 H) 445.2 [M+H] + 98.9%
2336 (CD 3OD) δ 8.52 (d, 1 H), 7.81-7.88 (m, 2 H), 7.69 (s, 1 H), 7.44 (dd, 1 H), 7.20-7.35 (m, 2 H), 6.80 (s, 1 H), 6.57 (s, 1 H), 4.46 (dd, 1 H), 3.83 (td, 1 H), 3.04-3.15 (m, 1 H), 2.84 (dd, 1 H), 2.69 (s, 3 H) 467.1 [M+H] + 100%
2337 (CD 3OD) δ 8.53 (d, 1 H), 7.82-7.91 (m, 3 H), 7.46 (dd, 1 H), 7.23-7.35 (m, 2 H), 6.83 (s, 1 H), 6.61 (s, 1 H), 4.48 (dd, 1 H), 3.77-3.87 (m, 1 H), 3.06-3.17 (m, 1 H), 2.84-2.90 (m, 1 H), 2.71 (s, 3 H) 467.2 [M+H] + 99.2%
2338 (CD 3OD) δ 8.43 (d, 1 H), 8.30 (d, 1 H), 7.66-7.76 (m, 1 H), 7.57 (s, 1 H), 7.41-7.52 (m, 2 H), 7.05 (dd, 1 H), 6.71 (td, 1 H), 6.51 (s, 1 H), 6.40 (s, 1 H), 4.31 (dd, 1 H), 3.62-3.74 (m, 1 H), 2.91-3.05 (m, 1 H), 2.72 (dd, 1 H) 403.2 [M+H] + 100%
2339 (CD 3OD) δ 8.43 (d, 1 H), 8.31 (d, 1 H), 7.72 (t, 1 H), 7.57 (s, 1 H), 7.42-7.53 (m, 2 H), 7.01-7.11 (m, 1 H), 6.71 (t, 1 H), 6.52 (s, 1 H), 6.40 (s, 1 H), 4.32 (dd, 1 H), 3.62-3.74 (m, 1 H), 2.91-3.05 (m, 1 H), 2.72 (dd, 1 H) 403.2 [M+H] + 94.1%
2340 (CD 3OD) δ 8.44 (d, 1 H), 8.17 (d, 1 H), 7.65-7.81 (m, 1 H), 7.54-7.60 (m, 1 H), 7.50 (dt, 1 H), 6.82-6.88 (m, 1 H), 6.64 (t, 1 H), 6.53 (s, 1 H), 6.41 (s, 1 H), 4.32 (dd, 1 H), 3.64-3.78 (m, 1 H), 2.92-3.05 (m, 1 H), 2.73 (dd, 1 H), 2.31 (s, 3 H) 417.2 [M+H] + 99.9%
2341 (CD 3OD) δ 8.44 (d, 1 H), 8.17 (d, 1 H), 7.72 (t, 1 H), 7.57 (s, 1 H), 7.50 (dt, 1 H), 6.85 (d, 1 H), 6.64 (t, 1 H), 6.53 (s, 1 H), 6.41 (s, 1 H), 4.33 (dd, 1 H), 3.70 (td, 1 H), 2.93-3.05 (m, 1 H), 2.73 (dd, 1 H), 2.31 (s, 3 H) 417.1 [M+H] + 99.3%
2342 (CD 3OD) δ 8.44 (d, 1 H), 7.80-7.95 (m, 2 H), 7.68 (s, 1 H), 7.58 (d, 1 H), 7.40 (d, 1 H), 7.18 (dd, 1 H), 6.84 (td, 1 H), 6.62 (s, 1 H), 6.53 (s, 1 H), 4.44 (dd, 1 H), 3.64-3.84 (m, 1 H), 3.00-3.18 (m, 1 H), 2.83 (br dd, 1 H), 2.62 (s, 3 H) 399.1 [M+H] + 100%
2343 (CD 3OD) δ 8.43 (d, 1 H), 7.79-7.97 (m, 2 H), 7.67 (s, 1 H), 7.57 (d, 1 H), 7.39 (d, 1 H), 7.12-7.22 (m, 1 H), 6.83 (td, 1 H), 6.62 (s, 1 H), 6.53 (s, 1 H), 4.43 (dd, 1 H), 3.77 (ddd, 1 H), 3.03-3.17 (m, 1 H), 2.75-2.88 (m, 1 H), 2.61 (s, 3 H) 399.1 [M+H] + 98.3%
2344 (CD 3OD) δ 8.29 (d, 1 H), 7.79-7.98 (m, 2 H), 7.68 (s, 1 H), 7.40 (d, 1 H), 6.97 (d, 1 H), 6.76 (t, 1 H), 6.63 (s, 1 H), 6.53 (s, 1 H), 4.44 (dd, 1 H), 3.69-3.85 (m, 1 H), 3.00-3.18 (m, 1 H), 2.75-2.88 (m, 1 H), 2.62 (s, 3 H), 2.43 (s, 3 H) 413.2 [M+H] + 99.5%
2345 (CD 3OD) δ 8.27 (d, 1 H), 7.77-7.93 (m, 2 H), 7.68 (s, 1 H), 7.37 (d, 1 H), 6.94 (d, 1 H), 6.73 (t, 1 H), 6.62 (s, 1 H), 6.52 (s, 1 H), 4.43 (dd, 1 H), 3.67-3.84 (m, 1 H), 3.02-3.15 (m, 1 H), 2.82 (br dd, 1 H), 2.60 (s, 3 H), 2.40 (s, 3 H) 413.2 [M+H] + 99.6%
2346 (CD 3OD) δ 8.57 (d, 1 H), 7.80-7.97 (m, 2 H), 7.72 (s, 1 H), 7.29-7.49 (m, 2 H), 6.76-7.15 (m, 3 H), 6.56 (s, 1 H), 4.46 (dd, 1 H), 3.68-3.89 (m, 1 H), 3.02-3.19 (m, 1 H), 2.76-2.91 (m, 1 H), 2.62 (s, 3 H) 449.1 [M+H] + 99.6%
2347 (CD 3OD) δ 8.57 (br d, 1 H), 7.79-7.96 (m, 2 H), 7.69 (s, 1 H), 7.35-7.51 (m, 2 H), 6.75-7.16 (m, 3 H), 6.56 (br s, 1 H), 4.46 (dd, 1 H), 3.66-3.90 (m, 1 H), 3.00-3.20 (m, 1 H), 2.74-2.92 (m, 1 H), 2.62 (s, 3 H) 449.1 [M+H] + 99.5%
2348 (CD 3OD) δ 8.48 (d, 1 H), 8.43 (s, 1 H), 7.74-7.81 (m, 1 H), 7.65 (s, 1 H), 7.12-7.22 (m, 2 H), 6.85-6.97 (m, 2 H), 6.67 (s, 1 H), 4.74 (br dd, 1 H), 3.61 (ddd, 1 H), 2.91-3.01 (m, 1 H), 2.71-2.80 (m, 1 H) 469.1 [M+H] + 98.0%
2349 (CD 3OD) δ 8.36 (d, 1 H), 8.28-8.33 (m, 1 H), 7.66 (dd, 1 H), 7.56 (s, 1 H), 7.00-7.10 (m, 2 H), 6.73-6.85 (m, 2 H), 6.55 (s, 1 H), 4.62 (br dd, 1 H), 3.42-3.55 (m, 1 H), 2.78-2.91 (m, 1 H), 2.63 (dd, 1 H) 469.1 [M+H] + 98.5%
2350 (CD 3OD) δ 8.40 (ddd, 1 H), 8.33 (d, 1 H), 8.25 (d, 1 H), 7.59 (s, 1 H), 7.34-7.45 (m, 1 H), 7.18 (d, 1 H), 6.73 (t, 1 H), 6.62 (s, 1 H), 6.35 (s, 1 H), 4.30 (dd, 1 H), 3.61-3.76 (m, 1 H), 2.92-3.07 (m, 1 H), 2.75 (dd, 1 H) 437.1 [M+H] + 100%
2351 (CD 3OD) δ 8.37-8.44 (m, 1 H), 8.34 (d, 1 H), 8.25 (br d, 1 H), 7.59 (s, 1 H), 7.31-7.44 (m, 1 H), 7.19 (d, 1 H), 6.73 (t, 1 H), 6.62 (s, 1 H), 6.35 (s, 1 H), 4.30 (dd, 1 H), 3.59-3.76 (m, 1 H), 2.91-3.07 (m, 1 H), 2.75 (br dd, 1 H) 437.1 [M+H] + 100%
2352 (CD 3OD) δ 8.52 (br d, 1 H), 7.84 (br d, 1 H), 7.67-7.75 (m, 2 H), 7.13-7.51 (m, 4 H), 6.73 (s, 1 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.78-3.90 (m, 1 H), 3.03-3.16 (m, 1 H), 2.84 (dd, 1 H), 2.68 (s, 3 H) 449.2 [M+H] + 100%
2353 (CD 3OD) δ 8.52 (d, 1 H), 7.84 (br d, 1 H), 7.65-7.75 (m, 2 H), 7.13-7.49 (m, 4 H), 6.73 (s, 1 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.79-3.90 (m, 1 H), 3.02-3.15 (m, 1 H), 2.84 (dd, 1 H), 2.68 (s, 3 H) 449.1 [M+H] + 99.8%
2354 (CD 3OD) δ 8.45 (d, 1 H), 8.17 (d, 1 H), 7.73 (t, 1 H), 7.58 (s, 1 H), 7.51 (dt, 1 H), 6.92 (d, 1 H), 6.70 (t, 1 H), 6.63 (s, 1 H), 6.41 (s, 1 H), 4.33 (dd, 1 H), 3.64-3.78 (m, 1 H), 2.94-3.11 (m, 2 H), 2.74 (dd, 1 H), 1.21 (t, 6 H) 445.2 [M+H] + 99.7%
2355 (CD 3OD) δ 8.44 (br d, 1 H), 8.17 (d, 1 H), 7.73 (t, 1 H), 7.58 (s, 1 H), 7.50 (dt, 1 H), 6.92 (d, 1 H), 6.67-6.74 (m, 1 H), 6.63 (s, 1 H), 6.41 (s, 1 H), 4.33 (br dd, 1 H), 3.65-3.77 (m, 1 H), 2.94-3.10 (m, 2 H), 2.74 (br dd, 1 H), 1.20 (t, 6 H) 445.2 [M+H] + 98.6%
2356 (CD 3OD) δ 8.68 (d, 1 H), 7.77-7.99 (m, 2 H), 7.69 (s, 1 H), 7.60 (d, 1 H), 7.40 (d, 1 H), 6.96 (t, 1 H), 6.82 (s, 1 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.66-3.91 (m, 1 H), 3.02-3.17 (m, 1 H), 2.85 (dd, 1 H), 2.62 (s, 3 H) 467.2 [M+H] + 100%
2357 (CD 3OD) δ 8.68 (d, 1 H), 7.78-7.97 (m, 2 H), 7.69 (s, 1 H), 7.60 (d, 1 H), 7.40 (d, 1 H), 6.96 (t, 1 H), 6.82 (s, 1 H), 6.56 (s, 1 H), 4.47 (dd, 1 H), 3.79 (td, 1 H), 3.05-3.20 (m, 1 H), 2.77-2.92 (m, 1 H), 2.61 (s, 3 H) 467.1 [M+H] + 97.8%
2358 (CD 3OD) δ 8.25 (d, 1 H), 7.78-7.98 (m, 2 H), 7.68 (s, 1 H), 7.38 (d, 1 H), 6.68-6.87 (m, 3 H), 6.41-6.63 (m, 1 H), 4.44 (dd, 1 H), 3.79 (td, 1 H), 2.99-3.20 (m, 1 H), 2.76-2.93 (m, 1 H), 2.61 (s, 3 H), 2.00-2.16 (m, 1 H), 0.72-1.04 (m, 4 H) 439.2 [M+H] + 100%
2359 (CD 3OD) δ 8.26 (d, 1 H), 7.80-8.04 (m, 2 H), 7.68 (s, 1 H), 7.39 (d, 1 H), 6.67-6.97 (m, 3 H), 6.39-6.64 (m, 1 H), 4.44 (dd, 1 H), 3.66-3.91 (m, 1 H), 3.03-3.21 (m, 1 H), 2.76-2.97 (m, 1 H), 2.61 (s, 3 H), 1.97-2.28 (m, 1 H), 0.70-1.07 (m, 4 H) 439.2 [M+H] + 99.7%
2360 (CD 3OD) δ 8.29 (d, 1 H), 8.11 (q, 1 H), 8.00 (dd, 1 H), 7.68 (s, 1 H), 7.21 (dd, 1 H), 6.97 (d, 1 H), 6.76 (t, 1 H), 6.63 (s, 1 H), 6.50 (s, 1 H), 4.42 (dd, 1 H), 3.79 (ddd, 1 H), 3.00-3.16 (m, 1 H), 2.84 (dd, 1 H), 2.43 (s, 3 H) 417.2 [M+H] + 100%
2361 (CD 3OD) δ 8.29 (d, 1 H), 8.11 (q, 1 H), 8.00 (dd, 1 H), 7.68 (s, 1 H), 7.21 (dd, 1 H), 6.97 (d, 1 H), 6.77 (t, 1 H), 6.63 (s, 1 H), 6.50 (s, 1 H), 4.42 (dd, 1 H), 3.79 (ddd, 1 H), 2.96-3.16 (m, 1 H), 2.84 (dd, 1 H), 2.43 (s, 3 H) 417.2 [M+H] + 99.8%
2362 (CD 3OD) δ 8.69 (d, 1 H), 8.11 (q, 1 H), 8.00 (dd, 1 H), 7.69 (s, 1 H), 7.61 (d, 1 H), 7.22 (dd, 1 H), 6.97 (t, 1 H), 6.82 (s, 1 H), 6.53 (br s, 1 H), 4.46 (dd, 1 H), 3.80 (ddd, 1 H), 3.00-3.19 (m, 1 H), 2.85 (br dd, 1 H) 471.2 [M+H] + 99.9%
2363 (CD 3OD) δ 8.68 (br d, 1 H), 8.07-8.16 (m, 1 H), 8.00 (br d, 1 H), 7.69 (s, 1 H), 7.61 (br d, 1 H), 7.22 (br d, 1 H), 6.97 (br t, 1 H), 6.82 (s, 1 H), 6.53 (br s, 1 H), 4.46 (dd, 1 H), 3.73-3.87 (m, 1 H), 3.00-3.16 (m, 1 H), 2.85 (br dd, 1 H) 471.2 [M+H] + 97.4%
2364 (CD 3OD) δ 8.71 (d, 1 H), 8.35-8.51 (m, 2 H), 7.90 (td, 1 H), 7.71 (s, 1 H), 7.51-7.66 (m, 1.3 H), 7.15-7.27 (m, 1 H), 6.99 (s, 0.7 H), 6.82-6.92 (m, 1 H), 6.58-6.70 (m, 1 H), 5.02 (br dd, 1 H), 3.75-3.87 (m, 0.7 H), 3.44 (td, 0.3 H), 3.15-3.26 (m, 0.7 H), 2.97-3.07 (m, 0.3 H), 2.86 (br dd, 1 H) 431.0 [M+H] + 100%
2365 (CD 3OD) δ 8.71 (d, 1 H), 8.35-8.50 (m, 2 H), 7.90 (td, 1 H), 7.74-7.77 (m, 1 H), 7.52-7.66 (m, 1.3 H), 7.15-7.26 (m, 1 H), 6.99 (s, 0.7 H), 6.81-6.92 (m, 1 H), 6.60-6.70 (m, 1 H), 5.03 (dd, 1 H), 3.74-3.86 (m, 0.7 H), 3.44 (td, 0.3 H), 3.16-3.28 (m, 0.7 H), 2.98-3.08 (m, 0.3 H), 2.82-2.90 (m, 1 H) 431.0 [M+H] + 100%
2366 (CD 3OD) δ 8.45 (br s, 1.4 H), 8.02 (br s, 0.6 H), 7.65 (s, 1 H), 7.58 (br d, 1 H), 7.15-7.25 (m, 1 H), 6.91-7.13 (m, 1.3 H), 6.73-6.90 (m, 1.3 H), 6.61 (br s, 0.7 H), 6.07-6.47 (m, 0.7 H), 4.67-4.84 (m, 0.6 H), 4.06 (br s, 0.4 H), 3.66 (br s, 0.5 H), 3.14-3.30 (m, 0.5 H), 2.93 (br s, 1 H), 2.70 (br d, 1 H) 384.1 [M+H] + 100%
2367 (CD 3OD) δ 8.46 (br s, 1.4 H), 8.03 (br s, 0.6 H), 7.65 (s, 1 H), 7.58 (br d, 1 H), 7.16-7.23 (m, 1 H), 6.92-7.12 (m, 1.3 H), 6.77-6.91 (m, 1.4 H), 6.61 (br s, 0.6 H), 6.17-6.44 (m, 0.7 H), 4.64-4.85 (m, 0.6 H), 4.06 (br s, 0.4 H), 3.66 (br s, 0.4 H), 3.16-3.31 (m, 0.6 H), 2.96 (br d, 1 H), 2.70 (br d, 1 H) 384.1 [M+H] + 99.8%
2368 (CD 3OD) δ 8.36-8.64 (m, 1 H), 7.77-8.34 (m, 1 H), 7.47-7.74 (m, 2 H), 7.02-7.42 (m, 2 H), 6.76-6.99 (m, 1.5 H), 6.09-6.70 (m, 1.5 H), 5.11 (q, 2 H), 4.06 (br d, 1 H), 3.70 (br s, 1 H), 2.90-3.04 (m, 1 H), 2.73 (dd, 1 H) 466.0 [M+H] + 100%
2369 (CD 3OD) δ 8.37-8.62 (m, 1 H), 7.79-8.35 (m, 1 H), 7.49-7.76 (m, 2 H), 7.01-7.43 (m, 2 H), 6.80-6.99 (m, 1.4 H), 6.13-6.70 (m, 1.6 H), 5.11 (q, 2 H), 4.05 (br s, 1 H), 3.70 (br s, 1 H), 2.90-3.04 (m, 1 H), 2.73 (br dd, 1 H) 466.0 [M+H] + 100%
2370 (CD 3OD) δ 8.26-8.62 (m, 1 H), 7.47-7.74 (m, 2.3 H), 7.09-7.43 (m, 1.7 H), 6.79-6.99 (m, 1.6 H), 5.98-6.71 (m, 2.4 H), 4.13 (br dd, 1 H), 3.56-3.79 (m, 0.6 H), 2.86-3.28 (m, 1.4 H), 2.74 (br d, 1 H) 399.0 [M+H] + 99.2%
2371 (CD 3OD) δ 8.34-8.60 (m, 1 H), 7.50-7.75 (m, 2.2 H), 7.13-7.49 (m, 1.8 H), 6.77-7.03 (m, 1.5 H), 5.99-6.69 (m, 2.5 H), 4.13 (br dd, 1 H), 3.57-3.76 (m, 0.6 H), 2.87-3.29 (m, 1.4 H), 2.74 (br d, 1 H) 399.0 [M+H] + 99.4%
2372 (CD 3OD) δ 8.35-8.53 (m, 1 H), 7.48-7.75 (m, 2 H), 7.08-7.28 (m, 1 H), 6.73-7.03 (m, 2 H), 6.28-6.70 (m, 1 H), 4.44 (dd, 1 H), 4.00-4.23 (m, 3 H), 3.68 (ddd, 1 H), 2.91-3.29 (m, 1 H), 2.67-2.87 (m, 1 H) 417.2 [M+H] + 100%
2373 (CD 3OD) δ 8.37-8.51 (m, 1 H), 7.46-7.75 (m, 2 H), 7.10-7.26 (m, 1 H), 6.75-7.00 (m, 2 H), 6.31-6.70 (m, 1 H), 4.44 (dd, 1 H), 4.04-4.24 (m, 3 H), 3.68 (ddd, 1 H), 2.89-3.29 (m, 1 H), 2.71-2.87 (m, 1 H) 417.2 [M+H] + 100%
2374 (CD 3OD) δ 8.34 (d, 1 H), 7.56 (s, 1 H), 7.49 (br d, 1 H), 7.04-7.17 (m, 1 H), 6.75 (td, 1.6 H), 6.25-6.56 (m, 1.4 H), 4.80-4.85 (m, 1 H), 4.02-4.21 (m, 1 H), 3.56-3.76 (m, 1 H), 2.61-3.10 (m, 2 H), 1.46 (br d, 3 H) 413.20 [M+H] + 100%
2375 (CD 3OD) δ 8.46 (d, 1 H), 7.68 (s, 1 H), 7.61 (br d, 1 H), 7.15-7.28 (m, 1 H), 6.87 (td, 1.6 H), 6.35-6.71 (m, 1.4 H), 4.92-4.96 (m, 1 H), 4.21 (br d, 1 H), 3.64-3.86 (m, 1 H), 2.72-3.20 (m, 2 H), 1.59 (br d, 3 H) 413.20 [M+H] + 96.6%
2376 (CD 3OD) δ 8.46 (d, 1 H), 7.68 (s, 1 H), 7.61 (br d, 1 H), 7.15-7.28 (m, 1 H), 6.87 (td, 1.6 H), 6.30-6.69 (m, 1.4 H), 4.93-4.96 (m, 1 H), 4.22 (br d, 1 H), 3.78 (br s, 1 H), 2.77-3.20 (m, 2 H), 1.48-1.65 (m, 3 H) 413.10 [M+H] + 100%
2377 (CD 3OD) δ 8.34 (d, 1 H), 7.56 (s, 1 H), 7.49 (br d, 1 H), 7.05-7.13 (m, 1 H), 6.75 (td, 1.6 H), 6.25-6.55 (m, 1.4 H), 4.80-4.85 (m, 1 H), 3.99-4.19 (m, 1 H), 3.66 (br s, 1 H), 2.59-3.09 (m, 2 H), 1.47 (br d, 3 H) 413.0 [M+H] + 97.3%
2378 (CD 3OD) δ 8.37-8.44 (m, 1 H), 7.68 (s, 1 H), 7.19-7.45 (m, 1 H), 6.78-6.97 (m, 2 H), 6.61-6.75 (m, 1 H), 4.93 (br d, 1 H), 3.63-3.80 (m, 0.7 H), 3.35-3.44 (m, 0.3 H), 2.91-3.20 (m, 1 H), 2.81 (br d, 1 H), 1.67 (s, 6 H) 428.1 [M+H] + 100%
2379 (CD 3OD) δ 8.37-8.44 (m, 1 H), 7.68 (s, 1 H), 7.22-7.42 (m, 1 H), 6.78-6.94 (m, 2 H), 6.60-6.73 (m, 1 H), 4.93 (br d, 1 H), 3.61-3.78 (m, 0.6 H), 3.32-3.42 (m, 0.4 H), 2.91-3.19 (m, 1 H), 2.80 (dd, 1 H), 1.67 (s, 6 H) 428.1 [M+H] + 100%
2380 (CD 3OD) δ 8.39 (s, 1 H), 8.17-8.28 (m, 1 H), 8.10 (s, 1 H), 7.68 (s, 1 H), 7.42-7.61 (m, 1 H), 7.02-7.12 (m, 1 H), 6.93 (br s, 1 H), 6.44-6.60 (m, 1 H), 5.05 (br dd, 1 H), 4.00 (s, 3 H), 3.67-3.84 (m, 1 H), 2.91-3.22 (m, 1 H), 2.82 (br d, 1 H), 2.23-2.36 (m, 3 H) 430.2 [M+H] + 100%
2381 (CD 3OD) δ 8.39 (s, 1 H), 8.15-8.28 (m, 1 H), 8.10 (s, 1 H), 7.68 (s, 1 H), 7.42-7.58 (m, 1 H), 7.01-7.11 (m, 1 H), 6.93 (s, 1 H), 6.44-6.61 (m, 1 H), 5.05 (br dd, 1 H), 4.00 (s, 3 H), 3.70-3.83 (m, 0.7 H), 3.39-3.44 (m, 0.3 H), 2.92-3.22 (m, 1 H), 2.70-2.88 (m, 1 H), 2.21-2.34 (m, 3 H) 430.2 [M+H] + 99.8%
2382 (CD 3OD) δ 8.35 (br s, 1 H), 7.93 (br s, 1 H), 7.67 (s, 2 H), 6.91-7.04 (m, 1 H), 6.60-6.90 (m, 3 H), 4.41-4.83 (m, 1 H), 3.36-3.87 (m, 1 H), 2.68-3.19 (m, 2 H), 1.64 (br s, 6 H) 411.2 [M+H]+ 100%
2383 (CD 3OD) δ 8.35 (br s, 1 H), 7.93 (br s, 1 H), 7.68 (s, 2 H), 6.92-7.08 (m, 1 H), 6.57-6.91 (m, 3 H), 4.42-4.83 (m, 1 H), 3.36-3.90 (m, 1 H), 2.73-3.24 (m, 2 H), 1.64 (br s, 6 H) 411.2 [M+H] + 99.1%
2384 (CD 3OD) δ 8.79 (br d, 1 H), 8.24-8.38 (m, 2 H), 8.10 (t, 1 H), 7.64-7.73 (m, 2 H), 7.51 (s, 0.3 H), 7.32-7.39 (m, 1 H), 6.96 (s, 0.7 H), 6.67-6.77 (m, 1 H), 6.44-6.53 (m, 1 H), 5.00 (br dd, 1 H), 3.75-3.86 (m, 0.7 H), 3.43 (br dd, 0.3 H), 2.97-3.26 (m, 1 H), 2.80-2.90 (m, 1 H), 2.34-2.42 (m, 3 H) 427.2 [M+H] + 97.4%
2385 (CD 3OD) δ 8.79 (br d, 1 H), 8.24-8.38 (m, 2 H), 8.10 (t, 1 H), 7.64-7.74 (m, 2 H), 7.51 (s, 0.3 H), 7.32-7.41 (m, 1 H), 6.96 (s, 0.7 H), 6.67-6.76 (m, 1 H), 6.44-6.55 (m, 1 H), 5.00 (br dd, 1 H), 3.75-3.86 (m, 0.7 H), 3.39-3.46 (m, 0.3 H), 2.98-3.27 (m, 1 H), 2.81-2.91 (m, 1 H), 2.33-2.41 (m, 3 H) 427.2 [M+H] + 99.6%
2386 (CD 3OD) δ 8.34-8.71 (m, 1 H), 7.66-7.80 (m, 1 H), 7.55-7.66 (m, 1 H), 7.50 (d, 1 H), 7.17-7.27 (m, 1 H), 7.01 (s, 0.6 H), 6.83-6.93 (m, 1 H), 6.62-6.80 (m, 1 H), 6.27-6.58 (m, 1 H), 6.14 (br s, 0.4 H), 3.92 (br dd, 1 H), 3.57-3.82 (m, 1.6 H), 3.36-3.47 (m, 0.4 H), 2.87-3.10 (m, 1 H), 2.67-2.86 (m, 1 H), 1.10 (br s, 1 H), 0.64-0.98 (m, 3 H) 374.2 [M+H] + 99.9%
2387 (CD 3OD) δ 8.40-8.62 (m, 1 H), 7.66-7.74 (m, 1 H), 7.54-7.66 (m, 1 H), 7.50 (d, 1 H), 7.21 (t, 1 H), 7.01 (s, 0.6 H), 6.83-6.94 (m, 1 H), 6.60-6.80 (m, 1 H), 6.29-6.60 (m, 1 H), 6.14 (s, 0.4 H), 3.85-4.00 (m, 1 H), 3.57-3.80 (m, 1.6 H), 3.35-3.46 (m, 0.4 H), 2.87-3.10 (m, 1 H), 2.69-2.85 (m, 1 H), 1.10 (br d, 1 H), 0.63-0.97 (m, 3 H) 374.2 [M+H] + 100%
2388 (CD 3OD) δ 8.31-8.40 (m, 1 H), 7.79-7.91 (m, 3 H), 7.53-7.78 (m, 2 H), 7.06-7.19 (m, 1 H), 6.83-7.05 (m, 3 H), 6.44-6.81 (m, 1.6 H), 5.88 (s, 0.4 H), 3.38-3.84 (m, 2 H), 2.57-3.16 (m, 2 H) 429.2 [M+H] + 91.1%
2389 (CD 3OD) δ 8.31-8.40 (m, 1 H), 7.79-7.92 (m, 3 H), 7.54-7.78 (m, 2 H), 7.07-7.19 (m, 1 H), 6.84-7.05 (m, 3 H), 6.44-6.80 (m, 1.6 H), 5.88 (s, 0.4 H), 3.40-3.83 (m, 2 H), 2.58-3.15 (m, 2 H) 429.2 [M+H] + 94.3%
2390 (CD 3OD) δ 8.31-8.51 (m, 1 H), 7.70 (s, 1 H), 6.69-7.19 (m, 3 H), 6.32-6.61 (m, 2 H), 4.15 (br d, 1 H), 3.85 (s, 3 H), 3.63-3.78 (m, 1 H), 2.69-3.10 (m, 2 H), 2.28 (br s, 3 H) 380.2 [M+H] + 100%
2391 (CD 3OD) δ 8.28-8.57 (m, 1 H), 7.70 (s, 1 H), 6.70-7.06 (m, 3 H), 6.29-6.63 (m, 2 H), 4.15 (br d, 1 H), 3.61-3.91 (m, 4 H), 2.67-3.10 (m, 2 H), 2.16-2.32 (m, 3 H) 380.2 [M+H] + 99.7%
2392 (CD 3OD) δ 7.94-8.01 (m, 1 H), 7.58 (d, 1 H), 6.16-6.86 (m, 4 H), 4.74-4.76 (m, 0.4 H), 4.22 (dd, 0.6 H), 3.79-3.89 (m, 6 H), 3.55 (ddd, 0.5 H), 2.80-3.18 (m, 1.5 H), 2.57-2.76 (m, 1 H), 2.25 (s, 3 H) 393.2 [M+H] + 100%
2393 (CD 3OD) δ 8.04-8.14 (m, 1 H), 7.70 (d, 1 H), 6.27-6.98 (m, 4 H), 4.86-4.88 (m, 0.4 H), 4.34 (dd, 0.6 H), 3.90-4.00 (m, 6 H), 3.61-3.74 (m, 0.5 H), 2.92-3.29 (m, 1.5 H), 2.70-2.89 (m, 1 H), 2.37 (s, 3 H) 393.2 [M+H] + 99.0%
2394 (CD 3OD) δ 7.98 (d, 1 H), 7.83 (dd, 1 H), 7.69 (d, 1 H), 7.46 (dd, 1.5 H), 7.11 (ddd, 1 H), 6.98 (s, 0.5 H), 6.70 (dd, 1 H), 6.42-6.64 (m, 1 H), 4.91-5.11 (m, 1 H), 4.10 (s, 3 H), 3.85-3.98 (m, 0.6 H), 3.35-3.43 (m, 0.4 H), 2.78-3.24 (m, 2 H), 2.49-2.71 (m, 3 H) 430.2 [M+H] + 100%
2395 (CD 3OD) δ 7.98 (d, 1 H), 7.83 (d, 1 H), 7.69 (d, 1 H), 7.46 (dd, 1.4 H), 7.11 (ddd, 1 H), 6.98 (s, 0.6 H), 6.70 (dd, 1 H), 6.41-6.65 (m, 1 H), 4.92-5.11 (m, 1 H), 4.10 (s, 3 H), 3.85-3.99 (m, 0.5 H), 3.34-3.45 (m, 0.5 H), 2.79-3.23 (m, 2 H), 2.43-2.71 (m, 3 H) 430.2 [M+H] + 93.5%
2396 (CD 3OD) δ 7.69 (d, 1 H), 7.51-7.63 (m, 1 H), 7.11-7.20 (m, 1 H), 6.90-7.05 (m, 2 H), 6.78-6.87 (m, 1 H), 6.45-6.73 (m, 1 H), 4.36 (dd, 1 H), 4.12 (d, 3 H), 3.69-3.81 (m, 0.5 H), 3.08-3.25 (m, 1 H), 2.92-3.03 (m, 0.5 H), 2.71-2.88 (m, 1 H) 433.1 [M+H] + 100%
2397 (CD 3OD) δ 7.69 (d, 1 H), 7.50-7.62 (m, 1 H), 7.11-7.19 (m, 1 H), 6.90-7.04 (m, 2 H), 6.77-6.87 (m, 1 H), 6.43-6.73 (m, 1 H), 4.36 (br dd, 1 H), 4.12 (d, 3 H), 3.71-3.81 (m, 0.5 H), 3.09-3.24 (m, 1 H), 2.91-3.03 (m, 0.5 H), 2.71-2.87 (m, 1 H) 433.1 [M+H] + 96.7%
2398 (CD 3OD) δ 8.30-8.38 (m, 1 H), 7.61-7.74 (m, 1 H), 6.89-7.00 (m, 2 H), 6.79-6.87 (m, 1 H), 6.76 (s, 0.6 H), 6.54 (s, 0.4 H), 4.48 (dd, 1 H), 4.06-4.23 (m, 3 H), 3.68 (ddd, 0.6 H), 3.11-3.29 (m, 1 H), 2.92-3.04 (m, 0.4 H), 2.72-2.88 (m, 1 H) 435.1 [M+H] + 100%
2399 (CD 3OD) δ 8.26-8.40 (m, 1 H), 7.70 (d, 1 H), 6.89-7.03 (m, 2 H), 6.79-6.88 (m, 1 H), 6.76 (s, 0.6 H), 6.54 (s, 0.4 H), 4.48 (dd, 1 H), 4.12-4.17 (m, 3 H), 3.68 (ddd, 0.6 H), 3.11-3.28 (m, 1 H), 2.93-3.04 (m, 0.4 H), 2.72-2.88 (m, 1 H) 435.1 [M+H] + 100%
2400 (CD 3OD) δ 8.35-8.62 (m, 2 H), 7.69 (s, 1 H), 7.00-7.47 (m, 2 H), 6.47-6.90 (m, 3 H), 4.34 (br d, 1 H), 3.73 (br s, 1 H), 2.94-3.25 (m, 1 H), 2.81 (br d, 1 H) 403.1 [M+H] + 97.1%
2401 (CD 3OD) δ 8.39-8.57 (m, 2 H), 7.69 (s, 1 H), 6.97-7.40 (m, 2 H), 6.44-6.88 (m, 3 H), 4.34 (br d, 1 H), 3.73 (br t, 1 H), 2.92-3.25 (m, 1 H), 2.81 (br d, 1 H) 403.1 [M+H] + 97.0%
2402 (CDCl 3) δ 8.04-8.19 (m, 1 H), 7.56 (d, 1 H), 7.33 (dd, 1 H), 6.88-7.01 (m, 2 H), 6.55-6.86 (m, 1 H), 6.29-6.54 (m, 1 H), 4.69-4.98 (m, 1 H), 3.23-3.85 (m, 1 H), 2.91-3.22 (m, 1 H), 2.74 (br d, 1 H), 2.28 (s, 3 H) 413.2 [M+H] + 100%
2403 (CDCl 3) δ 8.03-8.22 (m, 1 H), 7.58 (d, 1 H), 7.28-7.38 (m, 1 H), 6.85-7.03 (m, 2 H), 6.22-6.85 (m, 2 H), 4.63-5.07 (m, 1 H), 4.09-4.20 (m, 3 H), 3.26-3.83 (m, 1 H), 2.89-3.25 (m, 1 H), 2.69-2.86 (m, 1 H), 2.29 (s, 3 H) 413.2 [M+H] + 99.2%
2404 (CD 3OD) δ 8.51 (br s, 1 H), 7.56-7.75 (m, 2 H), 7.44 (s, 0.3 H), 7.12-7.30 (m, 1 H), 6.88 (s, 0.7 H), 6.52-6.72 (m, 1 H), 4.97 (br dd, 1 H), 3.34-3.78 (m, 1 H), 2.70-3.20 (m, 2 H), 2.30 (br d, 1 H), 1.18-1.30 (m, 4 H) 394.1 [M+H] + 100%
2405 (CD 3OD) δ 8.51 (br s, 1 H), 7.56-7.72 (m, 2 H), 7.44 (s, 0.3 H), 7.22 (br t, 1 H), 6.88 (s, 0.7 H), 6.53-6.75 (m, 1 H), 4.97 (br dd, 1 H), 3.34-3.79 (m, 1 H), 2.74-3.19 (m, 2 H), 2.20-2.41 (m, 1 H), 1.18-1.30 (m, 4 H) 394.2 [M+H] + 100%
2406 (CD 3OD) δ 8.63 (d, 1 H), 8.05 (br s, 1 H), 7.69 (s, 1 H), 6.96-7.31 (m, 2 H), 6.56-6.93 (m, 2 H), 4.76-4.81 (m, 0.3 H), 4.36 (br d, 0.7 H), 3.60-3.88 (m, 0.7 H), 3.39 (br s, 0.3 H), 2.72-3.25 (m, 2 H), 1.48-1.75 (m, 6 H) 511.1 [M+H] + 99.2%
2407 (CD 3OD) δ 8.63 (d, 1 H), 8.05 (br s, 1 H), 7.68 (s, 1 H), 6.95-7.30 (m, 2 H), 6.54-6.94 (m, 2 H), 4.84 (br s, 0.3 H), 4.36 (br d, 0.7 H), 3.73 (br t, 0.7 H), 3.39 (br s, 0.3 H), 2.70-3.23 (m, 2 H), 1.49-1.76 (m, 6 H) 511.2 [M+H] + 99.4%
2408 (CD 3OD) δ 7.86 (dd, 1 H), 7.53-7.77 (m, 1.5 H), 7.23-7.42 (m, 2 H), 6.81-7.04 (m, 1 H), 6.67 (s, 0.5 H), 4.96-5.02 (m, 1 H), 3.82-4.00 (m, 0.5 H), 2.93-3.32 (m, 1.5 H), 2.85 (dd, 1 H), 1.49 (d, 9 H) 460.2 [M+H] + 100%
2409 (CD 3OD) δ 7.75 (dd, 1 H), 7.36-7.65 (m, 1.5 H), 7.09-7.31 (m, 2 H), 6.71-6.91 (m, 1 H), 6.55 (s, 0.5 H), 4.85-4.92 (m, 1 H), 3.71-3.88 (m, 0.5 H), 2.82-3.20 (m, 1.5 H), 2.73 (dd, 1 H), 1.37 (d, 9 H) 460.2 [M+H] + 99.6%
2410 (CD 3OD) δ 8.64 (br s, 1 H), 7.86-8.18 (m, 1 H), 7.69 (br s, 1 H), 6.51-7.21 (m, 4 H), 4.47 (br d, 0.4 H), 4.11 (br d, 3 H), 3.67 (br s, 0.6 H), 2.64-3.25 (m, 3 H) 467.2 [M+H] + 100%
2411 (CD 3OD) δ 8.60-8.68 (m, 1 H), 7.89-8.21 (m, 1 H), 7.70 (d, 1 H), 6.63-7.13 (m, 4 H), 4.47 (dd, 0.4 H), 4.04-4.18 (m, 3 H), 3.67 (ddd, 0.6 H), 2.68-3.28 (m, 3 H) 467.2 [M+H] + 100%
2412 (CD 3OD) δ 7.71 (d, 1 H), 7.54-7.66 (m, 1 H), 7.14-7.23 (m, 1 H), 7.05 (d, 1 H), 6.96 (br s, 1 H), 6.46-6.86 (m, 1 H), 4.96 (br d, 0.5 H), 4.41 (dd, 0.5 H), 4.18 (d, 3 H), 3.73-3.85 (m, 0.5 H), 2.76-3.26 (m, 2.5 H) 451.1 [M+H] + 100%
2413 (CD 3OD) δ 7.57-7.63 (m, 1 H), 7.42-7.53 (m, 1 H), 7.02-7.11 (m, 1 H), 6.94 (d, 1 H), 6.84 (br s, 1 H), 6.36-6.71 (m, 1 H), 4.84 (br d, 0.5 H), 4.29 (br dd, 0.5 H), 4.06 (d, 3 H), 3.62-3.72 (m, 0.5 H), 2.64-3.12 (m, 2.5 H) 451.1 [M+H] + 98.4%
2414 (CD 3OD) δ 8.85-8.98 (m, 1 H), 8.77 (d, 1 H), 8.30 (d, 1 H), 8.08 (t, 1 H), 7.63-7.83 (m, 3 H), 7.29-7.53 (m, 1.4 H), 6.79-6.99 (m, 1.6 H), 4.93-5.04 (m, 1 H), 3.38-3.86 (m, 1 H), 2.95-3.26 (m, 1 H), 2.85 (br d, 1 H) 481.2 [M+H] + 100%
2415 (CD 3OD) δ 8.84-8.99 (m, 1 H), 8.77 (d, 1 H), 8.30 (d, 1 H), 8.08 (t, 1 H), 7.63-7.82 (m, 3 H), 7.31-7.52 (m, 1.4 H), 6.78-6.98 (m, 1.6 H), 4.95-5.06 (m, 1 H), 3.42-3.85 (m, 1 H), 2.93-3.26 (m, 1 H), 2.85 (br d, 1 H) 481.1 [M+H] + 99.8%
2416 (CD 3OD) δ 8.87-8.95 (m, 1 H), 8.35-8.43 (m, 1 H), 8.05-8.13 (m, 1 H), 7.67-7.81 (m, 2 H), 7.58 (s, 0.3 H), 7.31-7.38 (m, 1 H), 6.95 (s, 0.7 H), 6.76-6.84 (m, 1 H), 5.10 (dd, 1 H), 4.00 (s, 3 H), 3.37-3.81 (m, 1 H), 2.95-3.21 (m, 1 H), 2.78-2.87 (m, 1 H) 484.2 [M+H] + 100%
2417 (CD 3OD) δ 8.85-8.99 (m, 1 H), 8.38 (s, 1 H), 8.04-8.14 (m, 1 H), 7.63-7.82 (m, 2 H), 7.58 (s, 0.3 H), 7.29-7.39 (m, 1 H), 6.94 (s, 0.7 H), 6.74-6.85 (m, 1 H), 5.10 (br dd, 1 H), 4.00 (s, 3 H), 3.37-3.84 (m, 1 H), 2.93-3.22 (m, 1 H), 2.75-2.91 (m, 1 H) 484.2 [M+H] + 98.9%
2418 (CD 3OD) δ 7.64-8.07 (m, 2 H), 7.20-7.47 (m, 2 H), 6.41-7.09 (m, 2 H), 4.20 (dd, 1 H), 3.90 (d, 3 H), 3.62-3.78 (m, 0.5 H), 3.22 (td, 4.5 Hz, 0.5 H), 2.90-3.15 (m, 1 H), 2.65-2.89 (m, 1 H), 1.92-2.10 (m, 1 H), 0.77-1.11 (m, 4 H) 457.2 [M+H] + 95.3%
2419 (CD 3OD) δ 7.59-7.99 (m, 2 H), 7.15-7.54 (m, 2 H), 6.44-7.04 (m, 2 H), 4.03-4.29 (m, 1 H), 3.89 (d, 3 H), 3.67-3.76 (m, 0.5 H), 3.22 (td, 4.6 Hz, 0.5 H), 2.89-3.13 (m, 1 H), 2.60-2.89 (m, 1 H), 1.91-2.13 (m, 1 H), 0.83-1.03 (m, 4 H) 457.2 [M+H] + 81.0%
2420 (CD 3OD) δ 8.86-8.96 (m, 1 H), 7.72-7.81 (m, 1 H), 7.69 (s, 1 H), 7.29-7.45 (m, 1.3 H), 6.68-7.02 (m, 1.7 H), 4.93-5.01 (m, 1 H), 3.35-3.80 (m, 1 H), 2.94-3.20 (m, 1 H), 2.82 (br dd, 1 H), 1.84-1.93 (m, 6 H) 464.2 [M+H] + 99.5%
2421 (CD 3OD) δ 8.86-8.96 (m, 1 H), 7.72-7.81 (m, 1 H), 7.69 (s, 1 H), 7.31-7.44 (m, 1.3 H), 6.64-7.04 (m, 1.7 H), 4.97 (br dd, 1 H), 3.35-3.81 (m, 1 H), 2.93-3.20 (m, 1 H), 2.82 (br dd, 1 H), 1.78-1.97 (m, 6 H) 464.2 [M+H] + 98.2%
2422 (CD 3OD) δ 7.86 (br d, 1 H), 7.66 (s, 1 H), 7.31-7.37 (m, 1 H), 7.22-7.30 (m, 1 H), 6.84 (br s, 2 H), 4.78 (br s, 1 H), 4.36 (br s, 1 H), 3.87 (br s, 0.5 H), 3.34-3.52 (m, 0.5 H), 3.05 (br s, 1 H), 2.79 (dd, 3.6 Hz, 1 H), 2.34 (s, 3 H), 1.56 (br s, 3 H) 461.2 [M+H] + 99.2%
2423 (CD 3OD) δ 7.85 (br d, 1 H), 7.65 (s, 1 H), 7.31-7.40 (m, 1 H), 7.22-7.30 (m, 1 H), 6.83 (br s, 2 H), 4.68-4.77 (m, 1 H), 4.35 (br s, 1 H), 3.87 (br s, 0.5 H), 3.48 (br s, 0.5 H), 2.91-3.15 (m, 1 H), 2.68-2.87 (m, 1 H), 2.34 (s, 3 H), 1.56 (br s, 3 H) 461.2 [M+H] + 99.7%
2424 (CD 3OD) δ 8.63 (d, 2 H), 8.00 (d, 1 H), 7.56-7.67 (m, 2 H), 7.40-7.45 (m, 1 H), 7.19 (t, 1 H), 7.02-7.09 (m, 2 H), 6.63 (br s, 2 H), 4.63 (br s, 1 H), 3.48 (br s, 1 H), 3.00-3.10 (m, 1 H), 2.75 (dd, 1 H) 418.1 [M+H]+ 96.8%
2425 (CD 3OD) δ 8.63 (d, 2 H), 8.00 (d, 1 H), 7.55-7.67 (m, 2 H), 7.39-7.47 (m, 1 H), 7.18 (t, 1 H), 7.02-7.11 (m, 2 H), 6.64 (br s, 2 H), 4.64 (br s, 1 H), 3.48 (br s, 1 H), 3.00-3.10 (m, 1 H), 2.75 (dd, 1 H) 418.2 [M+H]+ 98.7%
2426 (CD 3OD) δ 9.02 (s, 1 H), 8.36 (s, 2 H), 7.35-7.74 (m, 2.3 H), 7.02-7.18 (m, 1 H), 6.65-6.93 (m, 1.7 H), 6.41-6.58 (m, 1 H), 4.94 (br dd, 1 H), 3.59-3.78 (m, 0.6 H), 3.25-3.40 (m, 0.4 H), 2.83-3.13 (m, 1 H), 2.77 (br s, 1 H) 470.1 [M+H] + 100%
2427 (CD 3OD) δ 9.14 (s, 1 H), 8.37-8.53 (m, 2 H), 7.54-7.77 (m, 2.3 H), 7.15-7.30 (m, 1 H), 6.80-7.03 (m, 1.7 H), 6.53-6.71 (m, 1 H), 4.92-5.13 (m, 1 H), 3.73-3.86 (m, 0.6 H), 3.38-3.52 (m, 0.4 H), 2.94-3.26 (m, 1 H), 2.86 (br d, 1 H) 470.1 [M+H] + 99.1%
2428 (CD 3OD) δ 9.13 (s, 1 H), 8.47 (s, 1 H), 7.80-7.98 (m, 1 H), 7.76 (d, 1 H), 7.57 (s, 0.5 H), 7.22-7.44 (m, 2 H), 6.99 (s, 0.5 H), 6.65-6.92 (m, 1 H), 4.96-5.17 (m, 1 H), 3.92-4.04 (m, 0.5 H), 3.36 (br d, 0.5 H), 2.86-3.26 (m, 2 H) 538.1 [M+H] + 100%
2429 (CD 3OD) δ 9.01 (s, 1 H), 8.34 (s, 1 H), 7.68-7.81 (m, 1 H), 7.62 (br d, 1 H), 7.45 (s, 0.5 H), 7.07-7.29 (m, 2 H), 6.87 (s, 0.5 H), 6.51-6.78 (m, 1 H), 4.84-5.07 (m, 1 H), 3.79-3.91 (m, 0.5 H), 3.24 (br d, 0.5 H), 2.70-3.13 (m, 2 H) 538.1 [M+H] + 99.4%
2430 (CD 3OD) δ 7.20-7.90 (m, 4.5 H), 6.52-7.03 (m, 1.5 H), 4.92-5.05 (m, 1 H), 3.78-3.98 (m, 1.5 H), 2.80-3.28 (m, 2.5 H), 2.39-2.61 (m, 4 H), 1.98-2.29 (m, 2 H) 458.1 [M+H] + 100%
2431 (CD 3OD) δ 7.21-7.88 (m, 4.5 H), 6.56-7.03 (m, 1.5 H), 4.92-5.04 (m, 1 H), 3.72-3.99 (m, 1.5 H), 2.80-3.25 (m, 2.5 H), 2.40-2.57 (m, 4 H), 1.96-2.27 (m, 2 H) 458.2 [M+H] + 94.4%
2432 (CD 3OD) δ 8.33 (d, 1 H), 7.66 (s, 1 H), 6.95 (dd, 1 H), 6.82 (td, 1 H), 6.64 (s, 1 H), 6.25 (s, 1 H), 4.19 (dd, 1 H), 3.67 (ddd, 1 H), 2.96-3.08 (m, 1 H), 2.78 (br dd, 1 H), 1.99-2.11 (m, 1 H), 0.98-1.16 (m, 4 H) 366.2 [M+H] + 98.2%
2433 (CD 3OD) δ 8.33 (d, 1 H), 7.67 (s, 1 H), 6.93-7.03 (m, 1 H), 6.82 (td, 1 H), 6.64 (s, 1 H), 6.25 (s, 1 H), 4.19 (dd, 1 H), 3.67 (ddd, 1 H), 2.90-3.08 (m, 1 H), 2.78 (dd, 1 H), 1.97-2.16 (m, 1 H), 0.89-1.18 (m, 4 H) 366.2 [M+H] + 98.8%
2434 (CD 3OD) δ 8.25-8.90 (m, 3 H), 8.08 (s, 1 H), 7.87-8.01 (m, 2 H), 7.57-7.78 (m, 2 H), 6.48-7.07 (m, 4 H), 4.93-5.08 (m, 1 H), 3.95 (s, 3 H), 3.41-3.84 (m, 1 H), 2.72-3.15 (m, 2 H) 482.2 [M+H] + 97.7%
2435 (CD 3OD) δ 8.26-8.89 (m, 3 H), 7.80-8.13 (m, 3 H), 7.55-7.76 (m, 2 H), 6.54-7.03 (m, 4 H), 4.92-5.07 (m, 1 H), 3.82-4.08 (m, 3 H), 3.40-3.81 (m, 1 H), 2.72-3.13 (m, 2 H) 482.2 [M+H] + 98.3%
2436 (CD 3OD) δ 8.62 (s, 1.6 H), 8.17-8.52 (m, 1.4 H), 7.92 (s, 1 H), 7.69 (s, 1 H), 7.44 (d, 1 H), 7.01 (br d, 1 H), 6.81 (br t, 1 H), 6.45-6.65 (m, 1 H), 6.43-7.20 (m, 1 H), 4.63 (br s, 1 H), 4.54 (s, 2 H), 3.52-3.93 (m, 1 H), 3.44 (s, 3 H), 3.00-3.15 (m, 1 H), 2.72-2.85 (m, 1 H), 2.46 (s, 3 H) 444.2 [M+H] + 100%
2437 (CD 3OD) δ 8.22-8.88 (m, 3 H), 7.97 (d, 1 H), 7.76 (br d, 1 H), 7.44 (dd, 1 H), 6.35-7.08 (m, 4 H), 4.58-4.75 (m, 1 H), 4.49-4.57 (m, 2 H), 3.50-3.89 (m, 1 H), 3.44 (s, 3 H), 3.00-3.17 (m, 1 H), 2.71-2.86 (m, 1 H), 2.46 (s, 3 H) 442.2 [M+H] + 90.1%
2438 (CD 3OD) δ 8.88 (s, 2 H), 8.11 (s, 1 H), 7.85-8.04 (m, 3 H), 7.59-7.77 (m, 2 H), 7.21-7.53 (m, 2 H), 6.30-7.08 (m, 2 H), 4.65-4.80 (m, 1 H), 3.97 (s, 3 H), 3.37-3.51 (m, 1 H), 3.03-3.16 (m, 1 H), 2.78 (br dd, 1 H) 532.2 [M+H] + 100%
2439 (CD 3OD) δ 8.88 (s, 2 H), 8.12 (s, 1 H), 7.85-8.03 (m, 3 H), 7.61-7.75 (m, 2 H), 7.28-7.52 (m, 2 H), 6.39-7.11 (m, 2 H), 4.66-4.78 (m, 1 H), 3.97 (s, 3 H), 3.36-3.52 (m, 1 H), 3.04-3.16 (m, 1 H), 2.78 (br dd, 1 H) 532.2 [M+H] + 99.6%
2440 (CD 3OD) δ 8.68 (d, 1 H), 8.13 (d, 1 H), 8.01 (td, 1 H), 7.84 (d, 1 H), 7.69 (s, 1 H), 7.55 (ddd, 1 H), 7.17-7.37 (m, 2 H), 6.80 (s, 1 H), 6.55 (s, 1 H), 4.45 (dd, 1 H), 3.74-3.94 (m, 1 H), 3.00-3.16 (m, 1 H), 2.86 (dd, 1 H) 453.1 [M+H] + 100%
2441 (CD 3OD) δ 8.67 (d, 1 H), 8.12 (d, 1 H), 8.00 (td, 1 H), 7.83 (d, 1 H), 7.67 (s, 1 H), 7.54 (ddd, 1 H), 7.12-7.34 (m, 2 H), 6.78 (s, 1 H), 6.53 (s, 1 H), 4.44 (dd, 1 H), 3.66-3.94 (m, 1 H), 2.96-3.22 (m, 1 H), 2.85 (dd, 1 H) 453.1 [M+H] + 98.3%
2442 (CD 3OD) δ 8.29 (d, 1 H), 7.67 (s, 1 H), 6.96 (d, 1 H), 6.77 (t, 1 H), 6.54 (s, 1 H), 6.30 (s, 1 H), 4.21 (dd, 1 H), 3.59-3.85 (m, 1 H), 2.95-3.14 (m, 1 H), 2.78 (dd, 1 H), 2.42 (d, 3 H), 2.40 (d, 3 H) 336.2 [M+H] + 100%
2443 (CD 3OD) δ 8.31 (br d, 1 H), 7.67 (s, 1 H), 7.00 (d, 1 H), 6.80 (t, 1 H), 6.54 (s, 1 H), 6.30 (s, 1 H), 4.22 (dd, 1 H), 3.70 (ddd, 1 H), 2.96-3.12 (m, 1 H), 2.79 (br dd, 1 H), 2.75 (s, 3 H), 2.43 (s, 3 H) 336.2 [M+H] + 99.7%
2444 (CD 3OD) δ 8.22-8.57 (m, 2 H), 8.12 (s, 0.8 H), 7.47-7.84 (m, 1 H), 7.18-7.29 (m, 0.2 H), 6.91-7.15 (m, 2 H), 6.66-6.91 (m, 2 H), 5.10 (br dd, 1 H), 4.02 (s, 3 H), 3.68-3.87 (m, 0.6 H), 3.36-3.48 (m, 0.4 H), 2.94-3.25 (m, 1 H), 2.77-2.92 (m, 1 H) 482.2 [M+H] + 100%
2445 (CD 3OD) δ 8.24-8.57 (m, 2 H), 8.12 (s, 0.8 H), 7.56-7.78 (m, 1 H), 7.17-7.30 (m, 0.2 H), 6.91-7.14 (m, 2 H), 6.66-6.90 (m, 2 H), 5.10 (dd, 1 H), 4.02 (s, 3 H), 3.67-3.89 (m, 0.6 H), 3.37-3.48 (m, 0.4 H), 2.95-3.27 (m, 1 H), 2.75-2.95 (m, 1 H) 482.1 [M+H] + 98.6%
2446 (CD 3OD) δ 8.90-8.96 (m, 1 H), 8.37 (s, 1 H), 8.03-8.11 (m, 1 H), 7.82 (s, 0.2 H), 7.69 (d, 1.5 H), 7.51-7.57 (m, 0.5 H), 6.77-6.96 (m, 1.8 H), 6.57-6.69 (m, 2 H), 5.06 (br dd, 1 H), 3.94-3.98 (m, 3 H), 3.78 (br s, 0.6 H), 3.37-3.50 (m, 0.4 H), 2.84-3.21 (m, 2 H) 482.2 [M+H] + 97.1%
2447 (CD 3OD) δ 8.94 (s, 1 H), 8.37 (s, 1 H), 8.00-8.14 (m, 1 H), 7.82 (s, 0.2 H), 7.65-7.73 (m, 1.5 H), 7.54 (br d, 0.5 H), 6.76-6.99 (m, 1.8 H), 6.57-6.72 (m, 2 H), 5.06 (br dd, 1 H), 3.93-3.99 (m, 3 H), 3.77 (br d, 0.6 H), 3.35-3.50 (m, 0.4 H), 2.85-3.16 (m, 2 H) 482.1 [M+H] + 99.0%
2448 (CD 3OD) δ 9.31-9.40 (m, 1 H), 8.68-8.79 (m, 2 H), 8.16-8.32 (m, 1 H), 7.06-7.67 (m, 1.5 H), 6.61-6.96 (m, 4.5 H), 4.83-4.97 (m, 1 H), 3.69 (ddd, 0.7 H), 3.34 (td, 0.3 H), 2.86-3.15 (m, 1 H), 2.69-2.81 (m, 1 H) 480.1 [M+H] + 96.6%
2449 (CD 3OD) δ 9.31-9.40 (m, 1 H), 8.68-8.79 (m, 2 H), 8.16-8.31 (m, 1 H), 7.08-7.65 (m, 1.5 H), 6.61-6.96 (m, 4.5 H), 4.83-4.98 (m, 1 H), 3.69 (ddd, 0.7 H), 3.34 (td, 0.3 H), 2.87-3.16 (m, 1 H), 2.75 (br d, 1 H) 480.2 [M+H] + 94.9%
2450 (DMSO- d 6) δ 11.99 (br s, 1 H), 8.21-8.74 (m, 3 H), 7.85 (d, 1 H), 7.55 (s, 1 H), 7.24 (dd, 1 H), 6.33-7.07 (m, 4 H), 4.34-4.66 (m, 1 H), 3.84 (s, 3 H), 3.25-3.31 (m, 1 H), 2.85-3.06 (m, 1 H), 2.67 (br s, 1 H), 2.40 (s, 3 H) 428.1 [M+H] + 100%
2451 (DMSO- d 6) δ 11.88-12.17 (m, 1 H), 8.20-8.87 (m, 3 H), 7.85 (d, 1 H), 7.55 (s, 1 H), 7.17-7.33 (m, 1 H), 6.37-7.09 (m, 4 H), 4.34-4.69 (m, 1 H), 3.84 (s, 3 H), 3.33 (br s, 1 H), 2.86-3.05 (m, 1 H), 2.63-2.73 (m, 1 H), 2.34-2.44 (m, 3 H) 428.2 [M+H] + 100%
2452 (CD 3OD) δ 9.31 (s, 2 H), 8.67 (d, 1 H), 7.84-8.15 (m, 5 H), 7.65 (s, 1 H), 7.25-7.51 (m, 3 H), 6.66 (br s, 2 H), 4.66 (br s, 1 H), 3.36-3.64 (m, 1 H), 3.08 (br s, 1 H), 2.77 (dd, 1 H) 529.2 [M+H] + 100%
2453 (CD 3OD) δ 9.31 (s, 2 H), 8.67 (d, 1 H), 7.87-8.12 (m, 5 H), 7.65 (s, 1 H), 7.15-7.52 (m, 3 H), 6.68 (br s, 2 H), 4.67 (br s, 1 H), 3.48 (br s, 1 H), 2.98-3.20 (m, 1 H), 2.77 (dd, 1 H) 529.2 [M+H] + 100%
2454 (CD 3OD) δ 8.39 (d, 2 H), 7.48-7.70 (m, 2 H), 7.07-7.25 (m, 2 H), 6.99 (d, 1 H), 6.56-6.72 (m, 2 H), 5.06 (br dd, 1 H), 3.50-3.65 (m, 1 H), 2.82-2.98 (m, 1 H), 2.70 (dd, 1 H) 352.1 [M+H] + 100%
2455 (CD 3OD) δ 8.27 (d, 2 H), 7.36-7.56 (m, 2 H), 6.95-7.16 (m, 2 H), 6.86 (d, 1 H), 6.46-6.62 (m, 2 H), 4.93-4.98 (m, 1 H), 3.38-3.50 (m, 1 H), 2.70-2.86 (m, 1 H), 2.58 (dd, 1 H) 352.1 [M+H] + 99.2%
2456 (CD 3OD) δ 8.33 (d, 1 H), 7.56 (s, 1 H), 7.19 (d, 1 H), 6.74 (t, 1 H), 6.55 (s, 1 H), 6.18 (s, 1 H), 4.12 (dd, 1 H), 3.58 (ddd, 1 H), 2.84-3.00 (m, 1 H), 2.61-2.76 (m, 1 H), 2.33 (s, 3 H) 356.1 [M+H] + 100%
2457 (CD 3OD) δ 8.33 (d, 1 H), 7.56 (s, 1 H), 7.19 (d, 1 H), 6.74 (t, 1 H), 6.55 (s, 1 H), 6.19 (s, 1 H), 4.12 (dd, 1 H), 3.58 (ddd, 1 H), 2.86-2.98 (m, 1 H), 2.67 (br dd, 1 H), 2.33 (s, 3 H) 356.1 [M+H] + 93.9%
2458 (CD 3OD) δ 9.05-9.25 (m, 1 H), 8.48 (s, 1 H), 8.29-8.42 (m, 1 H), 7.71 (s, 1 H), 7.56 (s, 0.3 H), 7.17-7.28 (m, 0.3 H), 6.94-7.08 (m, 2.2 H), 6.81-6.91 (m, 1.2 H), 6.69-6.79 (m, 1 H), 5.08 (dd, 0.7 H), 4.95 (br d, 0.3 H), 3.72-3.88 (m, 0.7 H), 3.43 (td, 0.3 H), 3.12-3.26 (m, 0.7 H), 2.95-3.08 (m, 0.3 H), 2.78-2.92 (m, 1 H) 536.1 [M+H] + 100%
2459 (CD 3OD) δ 9.05-9.26 (m, 1 H), 8.48 (s, 1 H), 8.29-8.42 (m, 1 H), 7.72 (s, 1 H), 7.56 (s, 0.3 H), 7.18-7.26 (m, 0.3 H), 6.94-7.08 (m, 2.2 H), 6.81-6.92 (m, 1.2 H), 6.69-6.79 (m, 1 H), 5.08 (dd, 0.7 H), 4.95 (br d, 0.3 H), 3.71-3.86 (m, 0.7 H), 3.43 (td, 0.3 H), 3.13-3.26 (m, 0.7 H), 2.96-3.09 (m, 0.3 H), 2.79-2.92 (m, 1 H) 536.2 [M+H] + 99.9%
2460 (CD 3OD) δ 8.45 (d, 1 H), 7.43-7.85 (m, 2 H), 7.15-7.28 (m, 1 H), 6.78-7.13 (m, 2 H), 6.58 (s, 1 H), 6.38 (s, 1 H), 4.32 (dd, 1 H), 3.77 (ddd, 1 H), 2.97-3.18 (m, 1 H), 2.83 (br dd, 1 H) 358.1 [M+H] + 99.3%
2461 (CD 3OD) δ 8.44 (d, 1 H), 7.44-7.84 (m, 2 H), 7.20 (dd, 1 H), 6.78-7.13 (m, 2 H), 6.57 (s, 1 H), 6.37 (s, 1 H), 4.31 (dd, 1 H), 3.76 (ddd, 1 H), 2.95-3.16 (m, 1 H), 2.82 (br dd, 1 H) 358.2 [M+H] + 99.4%
2462 (CD 3OD) δ 8.07-9.10 (m, 2 H), 7.85 (d, 1 H), 7.75 (d, 1 H), 7.40-7.66 (m, 2 H), 7.27-7.35 (m, 1 H), 7.16-7.23 (m, 2 H), 6.62 (br s, 2 H), 4.61-4.73 (m, 1 H), 3.36-3.98 (m, 1 H), 2.98-3.10 (m, 1 H), 2.75 (dd, 1 H), 1.96-2.05 (m, 1 H), 0.98-1.06 (m, 2 H), 0.74-0.80 (m, 2 H) 474.2 [M+H]+ 100%
2463 (CD 3OD) δ 8.41 (s, 2 H), 7.85 (d, 1 H), 7.74 (d, 1 H), 7.43-7.68 (m, 2 H), 7.26-7.34 (m, 1 H), 7.16-7.24 (m, 2 H), 6.62 (br s, 2 H), 4.60-4.72 (m, 1 H), 3.32-3.77 (m, 1 H), 2.99-3.10 (m, 1 H), 2.75 (dd, 1 H), 1.97-2.04 (m, 1 H), 0.99-1.05 (m, 2 H), 0.74-0.80 (m, 2 H) 474.2 [M+H]+ 99.4%
2464 (DMSO- d 6) δ 12.02 (br s, 1 H), 8.50 (d, 2 H), 7.88 (d, 1 H), 7.69 (br d, 1 H), 7.56 (s, 1 H), 7.07-7.33 (m, 3 H), 6.70 (br d, 2 H), 4.33-4.72 (m, 1 H), 3.84 (s, 4 H), 2.93 (br d, 1 H), 2.56-2.75 (m, 1 H) 448.1 [M+H] + 99.8%
2465 (DMSO- d 6) δ 12.02 (br s, 1 H), 8.51 (s, 2 H), 7.88 (d, 1 H), 7.69 (br d, 1 H), 7.56 (s, 1 H), 7.09-7.36 (m, 3 H), 6.33-6.93 (m, 2 H), 4.50 (br d, 1 H), 3.84 (s, 4 H), 2.95 (br s, 1 H), 2.57-2.78 (m, 1 H) 448.1 [M+H] + 99.5%
2466 (CD 3OD) δ 8.59 (d, 1 H), 7.68 (s, 1 H), 7.35-7.50 (m, 1 H), 6.81-7.15 (m, 2 H), 6.71 (s, 1 H), 6.33 (s, 1 H), 4.24 (dd, 1 H), 3.69 (ddd, 1 H), 2.98-3.11 (m, 1 H), 2.79 (dd, 1 H), 2.45 (s, 3 H) 372.2 [M+H] + 99.6%
2467 (CD 3OD) δ 8.47 (d, 1 H), 7.58 (s, 1 H), 7.32 (d, 1 H), 6.70-7.05 (m, 2 H), 6.60 (s, 1 H), 6.21 (s, 1 H), 4.12 (dd, 1 H), 3.49-3.65 (m, 1 H), 2.85-3.00 (m, 1 H), 2.62-2.74 (m, 1 H), 2.33 (s, 3 H) 372.1 [M+H] + 98.4%
2468 (CD 3OD) δ 9.05 (d, 2 H), 8.43-8.56 (m, 1 H), 7.69-7.75 (m, 2 H), 7.47 (br s, 0.3 H), 7.18-7.26 (m, 1 H), 6.79-7.01 (m, 2.7 H), 5.00 (td, 1 H), 3.78-3.85 (m, 0.6 H), 3.46 (td, 0.4 H), 2.86-3.26 (m, 2 H) 498.1 [M+H] + 100%
2469 (CD 3OD) δ 9.05 (d, 2 H), 8.42-8.53 (m, 1 H), 7.69-7.75 (m, 2 H), 7.47 (s, 0.3 H), 7.18-7.26 (m, 1 H), 6.80-7.01 (m, 2.7 H), 5.00 (td, 1 H), 3.82 (ddd, 0.6 H), 3.46 (td, 0.4 H), 2.85-3.26 (m, 2 H) 498.1 [M+H] + 100%
2470 (CD 3OD) δ 7.99-8.70 (m, 3 H), 7.76 (d, 1 H), 7.54 (s, 1 H), 7.20 (d, 1 H), 6.34-6.87 (m, 4 H), 4.44-4.59 (m, 1 H), 3.84 (s, 3 H), 3.27-3.59 (m, 1 H), 2.62-3.00 (m, 2 H), 2.27 (s, 3 H) 428.2 [M+H] + 100%
2471 (CD 3OD) δ 7.89-8.57 (m, 3 H), 7.74 (br d, 1 H), 7.54 (br s, 1 H), 7.17 (br d, 1 H), 6.29-6.79 (m, 4 H), 4.45-4.60 (m, 1 H), 3.82 (s, 3 H), 3.24-3.59 (m, 1 H), 2.60-3.01 (m, 2 H), 2.25 (br s, 3 H) 428.2 [M+H] + 100%
2472 (CD 3OD) δ 8.21-9.59 (m, 1 H), 7.79-7.95 (m, 3 H), 7.63 (s, 1 H), 7.24-7.45 (m, 3 H), 6.67 (br s, 2 H), 4.64 (br d, 1 H), 3.48 (br s, 1 H), 3.00-3.11 (m, 1 H), 2.95 (s, 6 H), 2.75 (dd, 1 H) 495.2 [M+H] + 99.7%
2473 (CD 3OD) δ 8.91 (br s, 1 H), 7.75-8.01 (m, 3 H), 7.64 (s, 1 H), 7.21-7.46 (m, 3 H), 6.47-6.98 (m, 2 H), 4.64 (br d, 1 H), 3.38-3.82 (m, 1 H), 2.99-3.11 (m, 1 H), 2.95 (s, 6 H), 2.75 (dd, 1 H) 495.2 [M+H] + 99.1%
2474 (CD 3OD) δ 8.26-9.27 (m, 1 H), 7.80-7.96 (m, 2 H), 7.55-7.69 (m, 2 H), 7.36 (dd, 1 H), 7.18 (dd, 1 H), 7.05 (d, 1 H), 6.50-6.96 (m, 2 H), 4.64 (br s, 1 H), 3.42-3.97 (m, 1 H), 3.00-3.15 (m, 1 H), 2.94 (s, 6 H), 2.75 (dd, 1 H) 461.2 [M+H] + 99.5%
2475 (CD 3OD) δ 8.11-9.10 (m, 1 H), 7.77-7.94 (m, 2 H), 7.53-7.70 (m, 2 H), 7.37 (dd, 1 H), 7.11-7.24 (m, 1 H), 7.06 (br d, 1 H), 6.47-6.92 (m, 2 H), 4.64 (br s, 1 H), 3.48 (br s, 1 H), 2.99-3.17 (m, 1 H), 2.95 (s, 6 H), 2.75 (br dd, 1 H) 461.2 [M+H] + 99.5%
2476 (CD 3OD) δ 8.77 (br s, 1 H), 8.54 (s, 2 H), 7.91 (d, 1 H), 7.59-7.72 (m, 2 H), 7.39 (d, 1 H), 6.44-7.13 (m, 3 H), 4.59 (br s, 1 H), 3.48 (br s, 1 H), 3.03-3.12 (m, 1 H), 2.85-2.91 (m, 2 H), 2.78 (br d, 1 H), 2.63-2.70 (m, 2 H), 2.34 (s, 6 H) 523.2 [M+H]+ 97.7%
2477 (CD 3OD) δ 8.78 (br s, 1 H), 8.54 (s, 2 H), 7.91 (d, 1 H), 7.56-7.73 (m, 2 H), 7.39 (d, 1 H), 6.41-7.16 (m, 3 H), 4.59 (br s, 1 H), 3.38-3.76 (m, 1 H), 3.02-3.12 (m, 1 H), 2.84-2.90 (m, 2 H), 2.74-2.81 (m, 1 H), 2.62-2.69 (m, 2 H), 2.33 (s, 6 H) 523.3 [M+H]+ 98.2%
2478 (CD 3OD) δ 8.27-8.76 (m, 3 H), 7.84 (s, 1 H), 7.67 (s, 1 H), 7.42 (dd, 1 H), 6.99-7.06 (m, 1 H), 6.48-6.90 (m, 3 H), 4.96 (br s, 1 H), 3.69 (t, 2 H), 3.34-3.42 (m, 4 H), 3.02-3.14 (m, 1 H), 2.95 (t, 2 H), 2.73-2.84 (m, 1 H), 2.42-2.50 (m, 3 H) 456.2 [M+H] + 100%
2479 (CD 3OD) δ 8.30 (s, 3 H), 7.85-7.95 (m, 1 H), 7.60-7.73 (m, 1 H), 7.42 (dd, 1 H), 6.97-7.06 (m, 1 H), 6.46-6.91 (m, 3 H), 4.94-5.08 (m, 1 H), 3.69 (t, 2 H), 3.37 (s, 4 H), 3.02-3.13 (m, 1 H), 2.89-2.99 (m, 2 H), 2.70-2.83 (m, 1 H), 2.50 (s, 3 H) 456.2 [M+H] + 91.8%
2480 (CD 3OD) δ 8.30 (d, 1 H), 7.67 (s, 1 H), 6.98 (d, 1 H), 6.78 (t, 1 H), 6.54 (s, 1 H), 6.31 (s, 1 H), 4.23 (dd, 1 H), 3.61-3.78 (m, 2 H), 2.98-3.12 (m, 1 H), 2.80 (br dd, 1 H), 2.33-2.52 (m, 7 H), 1.98-2.22 (m, 2 H) 376.2 [M+H] + 99.8%
2481 (CD 3OD) δ 8.30 (br d, 1 H), 7.69 (s, 1 H), 6.98 (br d, 1 H), 6.78 (t, 1 H), 6.54 (s, 1 H), 6.31 (s, 1 H), 4.23 (dd, 1 H), 3.61-3.77 (m, 2 H), 2.97-3.10 (m, 1 H), 2.80 (br dd, 1 H), 2.38-2.46 (m, 7 H), 2.00-2.18 (m, 2 H) 376.2 [M+H] + 99.8%
2482 (CD 3OD) δ 8.57 (d, 1 H), 7.46-7.69 (m, 2 H), 6.88 (t, 1 H), 6.61 (s, 1 H), 6.22 (s, 1 H), 4.15 (dd, 1 H), 3.51-3.67 (m, 2 H), 2.87-3.00 (m, 1 H), 2.70 (dd, 1 H), 2.23-2.35 (m, 4 H), 1.86-2.09 (m, 2 H) 430.2 [M+H] + 100%
2483 (CD 3OD) δ 8.57 (d, 1 H), 7.47-7.59 (m, 2 H), 6.83-6.92 (m, 1 H), 6.61 (s, 1 H), 6.22 (s, 1 H), 4.15 (dd, 1 H), 3.50-3.63 (m, 2 H), 2.87-2.96 (m, 1 H), 2.66-2.73 (m, 1 H), 2.25-2.35 (m, 4 H), 1.88-2.05 (m, 2 H) 430.1 [M+H] + 100%
2484 (CD 3OD) δ 8.46 (d, 1 H), 7.56 (s, 1 H), 7.32 (d, 1 H), 6.69-7.02 (m, 2 H), 6.16-6.64 (m, 2 H), 4.13 (dd, 1 H), 3.45-3.66 (m, 2 H), 2.85-2.98 (m, 1 H), 2.70 (dd, 1 H), 2.22-2.37 (m, 4 H), 1.85-2.08 (m, 2 H) 412.1 [M+H] + 99.9%
2485 (CD 3OD) δ 8.49 (br d, 1 H), 7.59 (s, 1 H), 7.35 (br d, 1 H), 6.74-7.04 (m, 2 H), 6.64 (s, 1 H), 6.24 (s, 1 H), 4.16 (dd, 1 H), 3.50-3.71 (m, 2 H), 2.89-3.01 (m, 1 H), 2.73 (br dd, 1 H), 2.24-2.40 (m, 4 H), 1.92-2.11 (m, 2 H) 412.2 [M+H] + 99.6%
2486 (CD 3OD) δ 7.67-7.79 (m, 2 H), 7.15-7.51 (m, 3 H), 6.69 (s, 1 H), 6.41 (s, 1 H), 4.37 (dd, 1 H), 3.73-3.87 (m, 1 H), 3.01-3.14 (m, 1 H), 2.86 (dd, 1 H) 426.1 [M+H] + 100%
2487 (CD 3OD) δ 7.64-7.80 (m, 2 H), 7.15-7.51 (m, 3 H), 6.69 (s, 1 H), 6.41 (s, 1 H), 4.37 (dd, 1 H), 3.74-3.87 (m, 1 H), 3.02-3.14 (m, 1 H), 2.86 (dd, 1 H) 426.1 [M+H] + 99.0%
2488 (CD 3OD) δ 8.58-8.75 (m, 1 H), 8.39 (s, 1 H), 8.10 (s, 1 H), 7.45-7.75 (m, 2.4 H), 7.17-7.37 (m, 1 H), 6.92 (s, 0.6 H), 6.55-6.75 (m, 1 H), 5.09 (br d, 1 H), 4.00 (s, 3 H), 3.68-3.83 (m, 0.7 H), 3.34-3.44 (m, 0.3 H), 3.07-3.23 (m, 1 H), 2.71-2.91 (m, 1 H) 494.1 [M+H] + 100%
2489 (CD 3OD) δ 8.59-8.75 (m, 1 H), 8.40 (s, 1 H), 8.10 (s, 1 H), 7.70 (s, 1 H), 7.47-7.62 (m, 1.4 H), 7.23-7.39 (m, 1 H), 6.93 (s, 0.6 H), 6.57-6.75 (m, 1 H), 5.08 (dd, 1 H), 4.02 (s, 3 H), 3.71-3.86 (m, 0.7 H), 3.33-3.46 (m, 0.3 H), 2.93-3.24 (m, 1 H), 2.58-2.89 (m, 1 H) 494.1 [M+H] + 99.4%
2490 (CD 3OD) δ 7.86 (d, 1 H), 7.73 (s, 1 H), 7.25-7.40 (m, 2 H), 6.74 (s, 1 H), 6.40 (s, 1 H), 4.37 (dd, 1 H), 3.73 (td, 1 H), 3.02-3.14 (m, 1 H), 2.86 (dd, 1 H) 444.1 [M+H] + 100%
2491 (CD 3OD) δ 7.86 (d, 1 H), 7.71 (s, 1 H), 7.22-7.42 (m, 2 H), 6.73 (s, 1 H), 6.40 (s, 1 H), 4.37 (dd, 1 H), 3.65-3.79 (m, 1 H), 3.00-3.13 (m, 1 H), 2.86 (dd, 1 H) 444.1 [M+H] + 98.2%
2492 (CD 3OD) δ 7.69 (s, 1 H), 7.62 (dd, 1 H), 7.20 (dd, 1 H), 7.06 (dd, 1 H), 6.71 (s, 1 H), 6.42 (s, 1 H), 4.37 (dd, 1 H), 3.83 (ddd, 1 H), 3.00-3.16 (m, 1 H), 2.86 (dd, 1 H) 410.1 [M+H] + 95.7%
2493 (CD 3OD) δ 7.57 (s, 1 H), 7.50 (dd, 1 H), 7.08 (dd, 1 H), 6.94 (dd, 1 H), 6.59 (s, 1 H), 6.30 (s, 1 H), 4.25 (dd, 1 H), 3.71 (ddd, 1 H), 2.89-3.04 (m, 1 H), 2.74 (dd, 1 H) 410.1 [M+H] + 84.1%
2494 (CD 3OD) δ 8.20-8.33 (m, 1 H), 7.70 (s, 1 H), 7.49 (br s, 0.3 H), 6.96 (s, 0.7 H), 6.70-6.85 (m, 3 H), 4.93-5.01 (m, 1 H), 3.77 (ddd, 0.7 H), 3.41 (td, 0.3 H), 2.93-3.21 (m, 1 H), 2.77-2.89 (m, 1 H), 2.60-2.70 (m, 3 H), 1.90-2.32 (m, 1 H), 0.96-1.10 (m, 2 H), 0.69-0.85 (m, 2 H) 390.2 [M+H] + 100%
2495 (CD 3OD) δ 8.21-8.33 (m, 1 H), 7.70 (s, 1 H), 7.45-7.53 (m, 0.3 H), 6.96 (s, 0.7 H), 6.69-6.86 (m, 3 H), 4.98 (br d, 1 H), 3.77 (ddd, 0.6 H), 3.39-3.46 (m, 0.4 H), 2.93-3.21 (m, 1 H), 2.79-2.90 (m, 1 H), 2.63-2.68 (m, 3 H), 2.04-2.17 (m, 1 H), 0.99-1.13 (m, 2 H), 0.75-0.87 (m, 2 H) 390.2 [M+H] + 100%
2496 (CD 3OD) δ 8.32-8.71 (m, 1 H), 7.49-8.01 (m, 3 H), 7.13-7.29 (m, 1 H), 6.37-6.98 (m, 3 H), 4.68-4.79 (m,0.5 H), 4.38-4.57 (m,0.5 H), 3.62-3.84 (m,0.5 H), 2.93-3.14 (m, 1 H), 2.64-2.92 (m, 1 H), 2.20 (br d, 1 H), 0.92-1.40 (m, 4.5 H) 375.2 [M+H] + 100%
2497 (CD 3OD) δ 8.35-8.60 (m, 1 H), 7.49-8.04 (m, 3 H), 7.13-7.30 (m, 1 H), 6.36-7.03 (m, 3 H), 4.70-4.80 (m, 0.5 H), 4.37-4.56 (m, 0.5 H), 3.62-3.89 (m, 0.5 H), 2.93-3.15 (m, 1 H), 2.65-2.92 (m, 1 H), 2.21 (br d, 1 H), 0.94-1.39 (m, 4.5 H) 375.2 [M+H] + 99.3%
2498 (CD 3OD) δ 8.33 (br s, 1 H), 7.79-8.17 (m, 1 H), 7.74 (s, 1 H), 7.67 (s, 1 H), 6.96-7.05 (m, 1 H), 6.83-6.96 (m, 2 H), 6.79 (br t, 1 H), 6.65 (br s, 1 H), 4.80-4.82 (m, 1 H), 3.92-4.12 (m, 3 H), 3.71-3.86 (m, 0.5 H), 3.45-3.54 (m, 0.5 H), 3.01-3.21 (m, 1 H), 2.72-2.92 (m, 1 H), 2.45 (s, 3 H) 429.2 [M+H] + 100%
2499 (CD 3OD) δ 8.24-8.43 (m, 1 H), 7.79-8.16 (m, 1 H), 7.61-7.78 (m, 2 H), 6.99 (br d, 1 H), 6.85-6.95 (m, 2 H), 6.73-6.82 (m, 1 H), 6.51-6.68 (m, 1 H), 4.77 (br dd, 1 H), 4.00 (s, 3 H), 3.66-3.88 (m, 0.6 H), 3.34-3.61 (m, 0.5 H), 2.97-3.20 (m, 0.5 H), 2.71-2.91 (m, 1 H), 2.45 (s, 3 H) 429.2 [M+H] + 100%
2500 (500 MHz, CD 3OD) δ 8.15-8.36 (m, 1 H), 7.54-7.78 (m, 1.5 H), 6.86-7.06 (m, 1.5 H), 6.70-6.85 (m, 1 H), 6.37-6.66 (m, 1 H), 5.09 (dd, 1 H), 3.63-3.79 (m, 0.5 H), 3.34-3.47 (m, 0.5 H), 2.91-3.20 (m, 1 H), 2.73-2.85 (m, 4 H), 2.35-2.49 (m, 3 H) 380.2 [M+H] + 100%
2501 (500 MHz, CD 3OD) δ 8.12-8.41 (m, 1 H), 7.68 (d, 1.5 H), 6.88-7.07 (m, 1.5 H), 6.69-6.81 (m, 1 H), 6.47-6.64 (m, 1 H), 5.09 (dd, 1 H), 3.61-3.78 (m, 0.5 H), 3.32-3.47 (m, 0.5 H), 2.90-3.21 (m, 1 H), 2.73-2.87 (m, 4 H), 2.34-2.45 (m, 3 H) 380.1 [M+H] + 99.4%
2502 (CD 3OD) δ 8.18-8.40 (m, 1.4 H), 8.01-8.17 (m, 2 H), 7.69 (s, 1 H), 7.44-7.64 (m, 2 H), 6.90-7.06 (m, 1.6 H), 6.70-6.84 (m, 1 H), 6.48-6.67 (m, 1 H), 5.49 (dd, 0.5 H), 4.90 (br s, 0.5 H), 3.61-3.86 (m, 0.7 H), 3.44 (td, 0.3 H), 2.98-3.25 (m, 1 H), 2.74-2.88 (m, 1 H), 2.29-2.51 (m, 3 H) 415.1 [M+H] + 100%
2503 (CD 3OD) δ 8.21-8.40 (m, 1.4 H), 8.07-8.19 (m, 2 H), 7.71 (s, 1 H), 7.51-7.66 (m, 2 H), 6.94-7.06 (m, 1.6 H), 6.72-6.85 (m, 1 H), 6.49-6.69 (m, 1 H), 5.44-5.60 (m, 0.5 H), 4.93-4.98 (m, 0.5 H), 3.67-3.86 (m, 0.7 H), 3.41-3.55 (m, 0.3 H), 3.12 (s, 1 H), 2.76-2.91 (m, 1 H), 2.35-2.53 (m, 3 H) 415.2 [M+H] + 99.6%
2504 (CD 3OD) δ 8.17-8.39 (m, 1 H), 7.71-8.05 (m, 1 H), 7.48-7.69 (m, 2 H), 6.52-6.99 (m, 5 H), 4.82-4.97 (m, 1 H), 3.83-4.06 (m, 3 H), 3.56-3.78 (m, 0.6 H), 3.34-3.49 (m, 0.4 H), 2.86-3.12 (m, 1 H), 2.59-2.82 (m, 1 H) 433.2 [M+H] + 100%
2505 (CD 3OD) δ 8.28-8.53 (m, 1 H), 7.84-8.15 (m, 1 H), 7.61-7.82 (m, 2 H), 6.69-7.10 (m, 5 H), 4.95-5.05 (m, 1 H), 4.02 (s, 3 H), 3.70-3.91 (m, 0.5 H), 3.45-3.59 (m, 0.5 H), 3.00-3.24 (m, 1 H), 2.73-2.94 (m, 1 H) 433.2 [M+H] + 96.1%
2506 (CD 3OD) δ 8.73 (br s, 1 H), 8.29 (br s, 1 H), 7.78-8.13 (m, 2 H), 7.58-7.77 (m, 2 H), 6.63-7.12 (m, 3 H), 4.51-4.84 (m, 1 H), 3.99 (s, 3 H), 3.37-3.88 (m, 1 H), 2.71-3.24 (m, 2 H) 483.2 [M+H] + 100%
2507 (CD 3OD) δ 8.73 (br s, 1 H), 8.29 (br s, 1 H), 7.77-8.12 (m, 2 H), 7.58-7.77 (m, 2 H), 6.62-7.10 (m, 3 H), 4.63 (br s, 1 H), 3.98 (s, 3 H), 3.80 (br s, 1 H), 2.78-3.26 (m, 2 H) 483.2 [M+H] + 99.1%
2508 (CD 3OD) δ 8.36 (d, 1 H), 7.67 (s, 1 H), 6.77-7.26 (m, 3 H), 6.64 (s, 1 H), 6.26 (s, 1 H), 4.20 (dd, 1 H), 3.59-3.80 (m, 1 H), 2.95-3.10 (m, 1 H), 2.80 (br dd, 1 H), 2.00-2.18 (m, 1 H), 0.94-1.22 (m, 4 H) 414.2 [M+H] + 100%
2509 (CD 3OD) δ 8.24 (d, 1 H), 7.57 (s, 1 H), 6.64-7.16 (m, 3 H), 6.52 (s, 1 H), 6.14 (s, 1 H), 4.08 (dd, 1 H), 3.47-3.67 (m, 1 H), 2.82-3.01 (m, 1 H), 2.68 (br dd, 1 H), 1.90-2.02 (m, 1 H), 0.86-1.08 (m, 4 H) 414.2 [M+H] + 99.1%
2510 (CD 3OD) δ 9.26 (s, 1 H), 8.60-8.77 (m, 3 H), 7.69 (s, 1 H), 7.59 (br d, 1 H), 6.95 (br t, 1 H), 6.81 (s, 1 H), 6.53 (s, 1 H), 4.46 (br dd, 1 H), 3.73-3.91 (m, 1 H), 3.03-3.18 (m, 1 H), 2.85 (br dd, 1 H) 454.1 [M+H] + 98.7%
2511 (CD 3OD) δ 9.27 (d, 1 H), 8.57-8.79 (m, 3 H), 7.69 (s, 1 H), 7.60 (br d, 1 H), 6.96 (t, 1 H), 6.81 (s, 1 H), 6.54 (s, 1 H), 4.46 (dd, 1 H), 3.71-3.88 (m, 1 H), 2.99-3.21 (m, 1 H), 2.86 (br dd, 1 H) 454.2 [M+H] + 95.4%
2512 (CD 3OD) δ 9.17 (dd, 1 H), 8.10-8.36 (m, 2 H), 7.77 (dd, 1 H), 7.58 (s, 1 H), 6.93 (d, 1 H), 6.56-6.82 (m, 2 H), 6.44 (s, 1 H), 4.37 (dd, 1 H), 3.63-3.86 (m, 1 H), 2.91-3.15 (m, 2 H), 2.75 (br dd, 1 H), 1.21 (t, 6 H) 428.2 [M+H] + 100%
2513 (CD 3OD) δ 9.17 (dd, 1 H), 8.08-8.35 (m, 2 H), 7.77 (dd, 1 H), 7.58 (s, 1 H), 6.92 (d, 1 H), 6.59-6.84 (m, 2 H), 6.44 (s, 1 H), 4.37 (dd, 1 H), 3.63-3.85 (m, 1 H), 2.91-3.14 (m, 2 H), 2.75 (br dd, 1 H), 1.21 (t, 6 H) 428.2 [M+H] + 99.3%
2514 (CD 3OD) δ 8.31-8.38 (m, 1 H), 7.67 (s, 1 H), 6.97 (dd, 1 H), 6.84 (td, 1 H), 6.65 (s, 1 H), 6.25 (s, 1 H), 4.20 (dd, 1 H), 3.62-3.76 (m, 1 H), 2.95-3.09 (m, 1 H), 2.80 (br dd, 1 H), 1.50 (s, 3 H), 1.21-1.29 (m, 2 H), 0.91-0.96 (m, 2 H) 380.2 [M+H] + 100%
2515 (CD 3OD) δ 8.35 (d, 1 H), 7.67 (s, 1 H), 6.97 (dd, 1 H), 6.84 (td, 1 H), 6.58-6.71 (m, 1 H), 6.25 (s, 1 H), 4.20 (dd, 1 H), 3.59-3.80 (m, 1 H), 2.95-3.11 (m, 1 H), 2.80 (dd, 1 H), 1.50 (s, 3 H), 1.21-1.34 (m, 2 H), 0.84-0.98 (m, 2 H) 380.2 [M+H] + 100%
2516 (CD 3OD) δ 9.42 (d, 1 H), 8.78 (s, 2 H), 8.32-8.65 (m, 1 H), 7.65-8.28 (m, 2 H), 6.67-7.17 (m, 4 H), 4.64 (br s, 1 H), 3.83 (br s, 0.5 H), 3.45-3.63 (m, 0.5 H), 2.99-3.30 (m, 1 H), 2.76-2.96 (m, 1 H) 431.2 [M+H] + 100%
2517 (CD 3OD) δ 9.42 (s, 1 H), 8.78 (s, 2 H), 8.31-8.65 (m, 1 H), 7.61-8.28 (m, 2 H), 6.69-7.11 (m, 4 H), 4.82 (br s, 1 H), 3.82 (br s, 0.5 H), 3.40-3.63 (m, 0.5 H), 2.98-3.30 (m, 1 H), 2.78-2.96 (m, 1 H) 431.2 [M+H] + 99.1%
2518 (CD 3OD) δ 8.29 (d, 1 H), 7.66 (s, 1 H), 7.05 (d, 1 H), 6.83 (t, 1 H), 6.60 (s, 1 H), 6.30 (s, 1 H), 4.23 (dd, 1 H), 3.71 (ddd, 1 H), 3.49-3.62 (m, 1 H), 3.18 (dt, 1 H), 2.93-3.09 (m, 5 H), 2.80 (br dd, 1 H), 1.32 (dd, 6 H) 440.2 [M+H] + 99.6%
2519 (CD 3OD) δ 8.29 (d, 1 H), 7.66 (s, 1 H), 7.05 (d, 1 H), 6.83 (t, 1 H), 6.60 (s, 1 H), 6.29 (br s, 1 H), 4.23 (dd, 1 H), 3.71 (ddd, 1 H), 3.49-3.62 (m, 1 H), 3.18 (dt, 1 H), 2.90-3.09 (m, 5 H), 2.79 (br dd, 1 H), 1.33 (dd, 6 H) 440.2 [M+H] + 98.9%
2520 (CD 3OD) δ 9.28 (d, 1 H), 8.68-8.75 (m, 2 H), 7.64-7.76 (m, 2 H), 7.14-7.51 (m, 3 H), 6.74 (s, 1 H), 6.52 (br s, 1 H), 4.45 (dd, 1 H), 3.80-3.95 (m, 1 H), 3.03-3.20 (m, 1 H), 2.86 (br dd, 1 H) 436.2 [M+H] + 100%
2521 (CD 3OD) δ 9.26 (d, 1 H), 8.67-8.74 (m, 2 H), 7.63-7.76 (m, 2 H), 7.13-7.49 (m, 3 H), 6.73 (s, 1 H), 6.51 (s, 1 H), 4.45 (dd, 1 H), 3.77-3.96 (m, 1 H), 2.99-3.15 (m, 1 H), 2.85 (br dd, 1 H) 436.1 [M+H] + 99.4%
2522 (CD 3OD) δ 7.53-7.70 (m, 2 H), 7.02-7.40 (m, 3 H), 6.56 (s, 1 H), 6.27 (s, 1 H), 4.13-4.29 (m, 1 H), 3.60-3.76 (m, 1 H), 2.86-3.00 (m, 1 H), 2.73 (dd, 1 H), 2.00 (t, 3 H) 422.2 [M+H] + 100%
2523 (CD 3OD) δ 7.63 (d, 1 H), 7.57 (s, 1 H), 7.05-7.39 (m, 3 H), 6.55 (s, 1 H), 6.26 (s, 1 H), 4.21 (dd, 1 H), 3.67 (td, 1 H), 2.89-3.02 (m, 1 H), 2.73 (dd, 1 H), 2.00 (t, 3 H) 422.2 [M+H] + 96.4%
2524 (CD 3OD) δ 8.30-8.65 (m, 1 H), 8.03 (d, 0.3 H), 7.41-7.84 (m, 3.7 H), 7.17-7.32 (m, 2.5 H), 6.54-6.97 (m, 2.5 H), 4.36-4.78 (m, 1 H), 3.38-3.86 (m, 1 H), 2.97-3.28 (m, 1 H), 2.76-2.91 (m, 1 H) 448.2 [M+H] + N/A
基於細胞之苯丙胺酸通量檢定
藉由用編碼pLVX-Puro中具有R408W突變之人類PAH之慢病毒轉導A375細胞，然後用嘌呤黴素選擇，直至產生穩定的細胞株來製備表現R408W PAH之細胞。在添加化合物前一小時，將A375 R408W細胞以40,000細胞/孔之密度接種至DMEM + 10% FBS的96孔盤中。將化合物再懸浮於DMSO中，且進行2倍系列稀釋以產生10點劑量曲線。將總體積為100 µl之化合物添加至經鋪盤之細胞，且DMSO之最終濃度係0.5%。對各化合物進行重複測試。在添加化合物後，將細胞置於5% CO 2、37 oC組織培養培養箱中24小時。在培養期之後，添加20 µM墨喋呤及800 µM 13C9,15N-苯丙胺酸。在4小時之後，移除細胞培養基。對於每一孔，將10 µl之細胞培養基之等分試樣與200 µl萃取緩衝液（80%乙腈/20% H 2O）合併。藉由液相層析質譜來評估 13C-酪胺酸濃度之判定。
在前述檢定中測試本文所揭示之特定化合物，且判定其等具有根據以下分數之AC 50：(A)小於或等於0.500 µM、(B)大於0.500且小於1.000 µM、(C)大於或等於1.000且小於5.000 µM、(D)大於或等於5.000 µM、(E)不適配、及(NT)未測試，如下所示。在對化合物進行多次測試的情況下，記述測試之平均值。
實例# AC 50
600 B
601 D
602 A
603 C
604 D
605 B
606 A
607 D
608 C
609 D
610 A
611 C
612 A
613 C
614 A
615 C
616 B
617 D
618 A
619 C
620 C
621 D
622 B
623 C
624 C
625 C
626 C
627 E
628 A
629 C
630 A
631 C
632 A
633 D
634 A
635 C
636 A
637 C
638 A
639 C
640 B
641 D
642 B
643 D
644 A
645 C
646 C
647 D
648 A
649 D
650 C
651 C
652 A
653 D
654 A
655 C
656 A
657 D
658 C
659 C
660 B
661 D
662 A
663 C
664 D
665 A
666 B
667 D
668 D
669 A
670 A
671 D
672 D
673 B
674 C
675 D
676 A
677 D
678 C
679 D
680 A
681 D
682 B
683 D
684 B
685 D
686 A
687 C
688 A
689 D
690 A
691 D
692 A
693 D
694 A
695 D
696 A
697 D
698 C
699 A
700 A
701 C
702 A
703 C
704 A
705 C
706 A
707 E
708 A
709 E
710 A
711 D
712 A
713 D
714 A
715 D
716 A
717 B
718 A
719 D
720 A
721 D
722 A
723 C
724 A
725 D
726 B
727 C
728 A
729 D
730 A
731 D
732 D
733 A
734 D
735 A
736 A
737 C
738 A
739 C
740 D
741 A
742 D
743 A
744 A
745 C
746 A
747 D
748 A
749 D
750 A
751 D
752 A
753 C
754 A
755 D
756 A
757 C
758 A
759 C
760 C
761 C
762 A
763 C
764 B
765 C
766 A
767 D
768 A
769 D
770 A
771 C
772 A
773 B
774 A
775 D
776 A
777 D
778 D
779 B
780 A
781 C
782 A
783 C
784 A
785 C
786 A
787 C
788 A
789 C
790 D
791 A
792 A
793 B
794 A
795 C
796 A
797 D
798 A
799 D
800 B
801 D
802 A
803 D
804 A
805 C
806 B
807 D
808 D
809 B
810 A
811 C
812 B
813 D
814 A
815 D
816 D
817 A
818 D
819 A
820 A
821 D
822 A
823 C
824 D
825 A
826 A
827 D
828 A
829 D
830 A
831 C
832 A
833 D
834 B
835 D
836 A
837 D
838 A
839 C
840 B
841 C
842 A
843 C
844 A
845 D
846 A
847 D
848 A
849 E
850 A
851 D
852 B
853 E
854 A
855 D
856 A
857 E
858 A
859 E
860 A
861 E
862 A
863 E
864 A
865 E
866 E
867 A
868 D
869 B
870 D
871 A
872 D
873 B
874 D
875 A
876 D
877 A
878 D
879 A
880 D
881 A
882 D
883 A
884 B
885 E
886 A
887 D
888 D
889 B
890 D
891 A
892 A
893 E
894 A
895 D
896 A
897 D
898 A
899 E
900 A
901 D
902 A
903 C
904 D
905 A
906 A
907 D
908 C
909 A
910 B
911 D
912 A
913 D
914 B
915 D
916 A
917 E
918 A
919 D
920 E
921 A
922 A
923 D
924 A
925 D
926 A
927 D
928 A
929 D
930 D
931 A
932 A
933 D
934 B
935 D
936 A
937 D
938 A
939 D
940 B
941 D
942 A
943 D
944 B
945 D
946 A
947 D
948 A
949 C
950 A
951 C
952 B
953 C
954 A
955 D
956 D
957 A
958 A
959 C
960 B
961 C
962 A
963 D
964 A
965 D
966 B
967 D
968 C
969 A
970 D
971 B
972 A
973 D
974 C
975 A
976 A
977 D
978 C
979 A
980 A
981 C
982 A
983 D
984 B
985 C
986 C
987 B
988 A
989 C
990 B
991 E
992 B
993 E
994 A
995 E
996 A
997 A
998 E
999 E
1000 B
1001 E
1002 E
1003 B
1004 E
1005 A
1006 E
1007 B
1008 E
1009 B
1010 B
1011 E
1012 B
1013 D
1014 A
1015 D
1016 A
1017 D
1018 A
1019 D
1020 A
1021 C
1022 A
1023 D
1024 A
1025 C
1026 C
1027 A
1028 A
1029 C
1030 A
1031 D
1032 B
1033 C
1034 B
1035 D
1036 B
1037 D
1038 A
1039 D
1040 B
1041 D
1042 A
1043 D
1044 A
1045 E
1046 D
1047 A
1048 E
1049 B
1050 A
1051 D
1052 A
1053 C
1054 A
1055 C
1056 A
1057 D
1058 B
1059 D
1060 A
1061 E
1062 A
1063 E
1064 B
1065 C
1066 A
1067 D
1068 A
1069 C
1070 A
1071 D
1072 B
1073 C
1074 B
1075 E
1076 A
1077 E
1078 A
1079 E
1080 E
1081 A
1082 A
1083 E
1084 A
1085 C
1086 A
1087 E
1088 B
1089 D
1090 B
1091 D
1092 B
1093 C
1094 A
1095 D
1096 D
1097 B
1098 D
1099 B
1100 B
1101 D
1102 B
1103 D
1104 A
1105 C
1106 A
1107 C
1108 D
1109 A
1110 B
1111 D
1112 A
1113 C
1114 B
1115 E
1116 A
1117 D
1118 A
1119 D
1120 A
1121 C
1122 C
1123 A
1124 B
1125 C
1126 A
1127 C
1128 B
1129 C
1130 B
1131 C
1132 A
1133 C
1134 A
1135 C
1136 C
1137 B
1138 A
1139 C
1140 B
1141 E
1142 A
1143 E
1144 B
1145 E
1146 A
1147 E
1148 B
1149 C
1150 A
1151 E
1152 A
1153 E
1154 A
1155 E
1156 A
1157 E
1158 B
1159 E
1160 C
1161 B
1162 A
1163 E
1164 A
1165 C
1166 B
1167 E
1168 B
1169 D
1170 D
1171 B
1172 A
1173 E
1174 B
1175 C
1176 A
1177 E
1178 A
1179 E
1180 B
1181 E
1182 C
1183 B
1184 B
1185 C
1186 B
1187 C
1188 B
1189 C
1190 B
1191 C
1192 A
1193 C
1194 C
1195 B
1196 A
1197 C
1198 B
1199 C
1200 B
1201 B
1202 A
1203 C
1204 A
1205 D
1206 B
1207 D
1208 A
1209 D
1210 B
1211 E
1212 B
1213 E
1214 A
1215 D
1216 E
1217 A
1218 E
1219 B
1220 A
1221 C
1222 A
1223 C
1224 B
1225 C
1226 A
1227 B
1228 E
1229 B
1230 A
1231 C
1232 A
1233 C
1234 A
1235 C
1236 A
1237 C
1238 A
1239 C
1240 A
1241 C
1242 C
1243 C
1244 C
1245 B
1246 B
1247 C
1248 C
1249 A
1250 A
1251 B
1252 A
1253 C
1254 C
1255 A
1256 A
1257 C
1258 B
1259 C
1260 A
1261 E
1262 A
1263 E
1264 E
1265 A
1266 A
1267 E
1268 A
1269 E
1270 A
1271 E
1272 A
1273 E
1274 A
1275 A
1276 A
1277 A
1278 A
1279 E
1280 A
1281 C
1282 E
1283 B
1284 A
1285 C
1286 A
1287 B
1288 B
1289 A
1290 C
1291 B
1292 A
1293 C
1294 C
1295 A
1296 A
1297 C
1298 C
1299 A
1300 A
1301 D
1302 A
1303 C
1304 A
1305 C
1306 A
1307 C
1308 A
1309 C
1310 C
1311 B
1312 C
1313 B
1314 A
1315 C
1316 A
1317 C
1318 C
1319 A
1320 C
1321 A
1322 C
1323 A
1324 C
1325 A
1326 A
1327 E
1328 A
1329 D
1330 A
1331 C
1332 A
1333 C
1334 A
1335 D
1336 C
1337 B
1338 D
1339 A
1340 B
1341 C
1342 B
1343 C
1344 C
1345 C
1346 B
1347 C
1348 A
1349 D
1350 A
1351 D
1352 A
1353 D
1354 B
1355 C
1356 A
1357 D
1358 A
1359 C
1360 D
1361 B
1362 B
1363 D
1364 A
1365 D
1366 A
1367 C
1368 A
1369 C
1370 A
1371 E
1372 A
1373 C
1374 A
1375 D
1376 D
1377 A
1378 A
1379 D
1380 C
1381 B
1382 A
1383 D
1384 A
1385 E
1386 B
1387 E
1388 A
1389 D
1390 B
1391 C
1392 C
1393 A
1394 A
1395 D
1396 A
1397 C
1398 A
1399 C
1400 A
1401 C
1402 B
1403 E
1404 C
1405 A
1406 A
1407 D
1408 C
1409 A
1410 C
1411 A
1412 E
1413 B
1414 A
1415 C
1416 A
1417 C
1418 C
1419 B
1420 D
1421 A
1422 A
1423 D
1424 A
1425 C
1426 A
1427 D
1428 D
1429 A
1430 D
1431 A
1432 C
1433 A
1434 B
1435 C
1436 B
1437 C
1438 B
1439 D
1440 B
1441 D
1442 A
1443 C
1444 A
1445 C
1446 B
1447 D
1448 B
1449 C
1450 A
1451 D
1452 A
1453 D
1454 D
1455 A
1456 A
1457 C
1458 C
1459 A
1460 E
1461 B
1462 A
1463 C
1464 C
1465 A
1466 A
1467 C
1468 A
1469 D
1470 A
1471 C
1472 B
1473 C
1474 A
1475 C
1476 A
1477 C
1478 A
1479 C
1480 A
1481 C
1482 A
1483 C
1484 A
1485 C
1486 A
1487 D
1488 A
1489 C
1490 B
1491 C
1492 B
1493 C
1494 A
1495 D
1496 A
1497 C
1498 E
1499 B
1500 A
1501 D
1502 B
1503 D
1504 A
1505 D
1506 A
1507 D
1508 A
1509 D
1510 B
1511 C
1512 A
1513 C
1514 A
1515 D
1516 E
1517 A
1518 E
1519 A
1520 A
1521 C
1522 A
1523 D
1524 D
1525 B
1526 B
1527 D
1528 A
1529 C
1530 D
1531 A
1532 A
1533 D
1534 C
1535 B
1536 D
1537 B
1538 B
1539 D
1540 B
1541 C
1542 B
1543 C
1544 A
1545 C
1546 B
1547 D
1548 B
1549 C
1550 A
1551 C
1552 A
1553 E
1554 D
1555 C
1556 A
1557 C
1558 C
1559 A
1560 D
1561 A
1562 B
1563 C
1564 D
1565 A
1566 B
1567 C
1568 A
1569 D
1570 A
1571 C
1572 C
1573 B
1574 C
1575 A
1576 E
1577 B
1578 B
1579 D
1580 A
1581 D
1582 B
1583 D
1584 B
1585 D
1586 C
1587 A
1588 D
1589 B
1590 E
1591 B
1592 B
1593 C
1594 A
1595 D
1596 A
1597 D
1598 B
1599 D
1600 B
1601 E
1602 B
1603 E
1604 B
1605 D
1606 E
1607 B
1608 B
1609 D
1610 B
1611 E
1612 D
1613 A
1614 B
1615 E
1616 A
1617 D
1618 A
1619 C
1620 D
1621 A
1622 C
1623 A
1624 B
1625 D
1626 B
1627 D
1628 B
1629 E
1630 B
1631 E
1632 B
1633 E
1634 B
1635 E
1636 E
1637 A
1638 E
1639 B
1640 B
1641 D
1642 D
1643 B
1644 A
1645 D
1646 B
1647 D
1648 B
1649 D
1650 B
1651 E
1652 B
1653 D
1654 B
1655 E
1656 D
1657 B
1658 B
1659 E
1660 B
1661 E
1662 B
1663 D
1664 A
1665 C
1666 B
1667 D
1668 B
1669 D
1670 B
1671 E
1672 A
1673 D
1674 B
1675 E
1676 B
1677 D
1678 D
1679 A
1680 B
1681 E
1682 A
1683 E
1684 A
1685 E
1686 E
1687 B
1688 E
1689 A
1690 B
1691 D
1692 A
1693 C
1694 A
1695 D
1696 B
1697 E
1698 A
1699 D
1700 C
1701 B
1702 A
1703 E
1704 A
1705 E
1706 A
1707 D
1708 B
1709 D
1710 D
1711 B
1712 B
1713 D
1714 A
1715 E
1716 A
1717 D
1718 B
1719 C
1720 B
1721 E
1722 D
1723 B
1724 A
1725 E
1726 B
1727 E
1728 B
1729 D
1730 A
1731 D
1732 E
1733 A
1734 E
1735 A
1736 E
1737 B
1738 E
1739 A
1740 D
1741 B
1742 A
1743 C
1744 C
1745 D
1746 A
1747 D
1748 B
1749 E
1750 B
1751 D
1752 A
1753 E
1754 A
1755 D
1756 D
1757 A
1758 E
1759 B
1760 A
1761 E
1762 A
1763 C
1764 C
1765 B
1766 E
1767 A
1768 A
1769 C
1770 B
1771 D
1772 B
1773 D
1774 A
1775 D
1776 A
1777 D
1778 A
1779 E
1780 A
1781 D
1782 B
1783 E
1784 B
1785 E
1786 B
1787 C
1788 B
1789 D
1790 B
1791 D
1792 A
1793 E
1794 B
1795 D
1796 B
1797 E
1798 D
1799 B
1800 A
1801 E
1802 B
1803 D
1804 C
1805 A
1806 E
1807 B
1808 E
1809 A
1810 B
1811 E
1812 B
1813 E
1814 A
1815 D
1816 D
1817 A
1818 D
1819 A
1820 D
1821 A
1822 D
1823 B
1824 E
1825 B
1826 E
1827 B
1828 C
1829 A
1830 D
1831 B
1832 E
1833 B
1834 E
1835 B
1836 E
1837 B
1838 A
1839 D
1840 A
1841 D
1842 D
1843 A
1844 D
1845 A
1846 E
1847 A
1848 D
1849 A
1850 B
1851 C
1852 B
1853 C
1854 D
1855 A
1856 E
1857 B
1858 A
1859 E
1860 E
1861 A
1862 D
1863 A
1864 E
1865 A
1866 A
1867 E
1868 A
1869 D
1870 A
1871 D
1872 D
1873 B
1874 D
1875 A
1876 B
1877 D
1878 B
1879 E
1880 A
1881 D
1882 A
1883 E
1884 A
1885 D
1886 A
1887 D
1888 D
1889 A
1890 E
1891 A
1892 E
1893 A
1894 D
1895 A
1896 D
1897 B
1898 A
1899 C
1900 A
1901 D
1902 A
1903 E
1904 D
1905 A
1906 A
1907 D
1908 A
1909 C
1910 D
1911 A
1912 D
1913 A
1914 A
1915 D
1916 A
1917 D
1918 B
1919 E
1920 A
1921 E
1922 A
1923 D
1924 A
1925 D
1926 D
1927 A
1928 B
1929 E
1930 A
1931 D
1932 D
1933 B
1934 A
1935 E
1936 A
1937 C
1938 A
1939 C
1940 D
1941 A
1942 E
1943 A
1944 A
1945 C
1946 A
1947 E
1948 A
1949 C
1950 D
1951 A
1952 D
1953 A
1954 C
1955 A
1956 E
1957 B
1958 E
1959 A
1960 B
1961 D
1962 B
1963 D
1964 B
1965 D
1966 A
1967 D
1968 A
1969 D
1970 A
1971 D
1972 B
1973 D
1974 B
1975 D
1976 D
1977 B
1978 D
1979 A
1980 E
1981 B
1982 D
1983 A
1984 A
1985 D
1986 A
1987 C
1988 E
1989 B
1990 E
1991 B
1992 D
1993 A
1994 D
1995 A
1996 C
1997 B
1998 A
1999 D
2000 C
2001 D
2002 B
2003 D
2004 B
2005 D
2006 E
2007 A
2008 E
2009 A
2010 A
2011 D
2012 E
2013 A
2014 A
2015 C
2016 A
2017 D
2018 A
2019 D
2020 A
2021 D
2022 B
2023 D
2024 A
2025 E
2026 E
2027 B
2028 A
2029 D
2030 A
2031 C
2032 A
2033 D
2034 B
2035 D
2036 A
2037 D
2038 C
2039 A
2040 A
2041 C
2042 B
2043 C
2044 D
2045 B
2046 D
2047 B
2048 B
2049 D
2050 A
2051 D
2052 B
2053 D
2054 B
2055 D
2056 D
2057 A
2058 E
2059 B
2060 D
2061 B
2062 D
2063 A
2064 A
2065 E
2066 B
2067 D
2068 B
2069 D
2070 A
2071 D
2072 D
2073 B
2074 A
2075 C
2076 B
2077 D
2078 B
2079 E
2080 A
2081 D
2082 E
2083 A
2084 D
2085 A
2086 A
2087 D
2088 D
2089 A
2090 D
2091 A
2092 D
2093 A
2094 E
2095 A
2096 D
2097 B
2098 A
2099 E
2100 A
2101 E
2102 A
2103 E
2104 A
2105 E
2106 A
2107 E
2108 E
2109 B
2110 A
2111 E
2112 B
2113 D
2114 B
2115 C
2116 A
2117 C
2118 A
2119 C
2120 A
2121 C
2122 A
2123 C
2124 A
2125 C
2126 D
2127 A
2128 E
2129 A
2130 D
2131 A
2132 C
2133 A
2134 C
2135 A
2136 A
2137 D
2138 A
2139 E
2140 A
2141 E
2142 A
2143 E
2144 A
2145 E
2146 E
2147 A
2148 A
2149 D
2150 D
2151 A
2152 E
2153 A
2154 D
2155 A
2156 E
2157 B
2158 E
2159 B
2160 D
2161 A
2162 B
2163 D
2164 A
2165 D
2166 D
2167 A
2168 C
2169 A
2170 A
2171 D
2172 A
2173 C
2174 A
2175 D
2176 D
2177 B
2178 B
2179 D
2180 B
2181 D
2182 B
2183 D
2184 E
2185 A
2186 E
2187 A
2188 D
2189 B
2190 E
2191 B
2192 E
2193 A
2194 E
2195 A
2196 E
2197 B
2198 B
2199 E
2200 A
2201 D
2202 D
2203 A
2204 E
2205 A
2206 B
2207 D
2208 B
2209 E
2210 C
2211 E
2212 A
2213 D
2214 A
2215 E
2216 B
2217 E
2218 C
2219 D
2220 D
2221 C
2222 E
2223 C
2224 C
2225 A
2226 D
2227 B
2228 D
2229 A
2230 D
2231 A
2232 D
2233 A
2234 B
2235 D
2236 A
2237 D
2238 C
2239 A
2240 B
2241 D
2242 B
2243 D
2244 B
2245 D
2246 D
2247 A
2248 E
2249 A
2250 E
2251 A
2252 E
2253 A
2254 A
2255 C
2256 A
2257 D
2258 D
2259 B
2260 D
2261 B
2262 B
2263 D
2264 B
2265 D
2266 D
2267 A
2268 D
2269 A
2270 A
2271 D
2272 A
2273 D
2274 B
2275 D
2276 A
2277 D
2278 D
2279 A
2280 A
2281 D
2282 D
2283 A
2284 D
2285 A
2286 D
2287 A
2288 E
2289 A
2290 E
2291 C
2292 A
2293 D
2294 D
2295 B
2296 A
2297 D
2298 C
2299 A
2300 E
2301 B
2302 E
2303 A
2304 E
2305 B
2306 D
2307 A
2308 D
2309 B
2310 C
2311 A
2312 C
2313 A
2314 A
2315 E
2316 A
2317 E
2318 D
2319 A
2320 E
2321 A
2322 D
2323 B
2324 D
2325 A
2326 E
2327 C
2328 D
2329 C
2330 B
2331 D
2332 B
2333 D
2334 D
2335 B
2336 B
2337 E
2338 B
2339 D
2340 D
2341 B
2342 C
2343 D
2344 D
2345 B
2346 D
2347 B
2348 B
2349 E
2350 B
2351 E
2352 B
2353 E
2354 D
2355 B
2356 E
2357 B
2358 D
2359 B
2360 D
2361 A
2362 E
2363 B
2364 D
2365 C
2366 C
2367 E
2368 C
2369 D
2370 C
2371 E
2372 C
2373 E
2374 E
2375 E
2376 C
2377 C
2378 C
2379 E
2380 C
2381 D
2382 C
2383 E
2384 C
2385 D
2386 C
2387 E
2388 C
2389 E
2390 C
2391 E
2392 E
2393 C
2394 D
2395 C
2396 C
2397 E
2398 C
2399 C
2400 A
2401 C
2402 E
2403 C
2404 C
2405 D
2406 A
2407 E
2408 E
2409 C
2410 B
2411 E
2412 C
2413 E
2414 C
2415 C
2416 C
2417 C
2418 E
2419 C
2420 C
2421 C
2422 C
2423 E
2424 C
2425 E
2426 C
2427 D
2428 C
2429 C
2430 C
2431 C
2432 E
2433 C
2434 C
2435 D
2436 C
2437 D
2438 C
2439 E
2440 C
2441 E
2442 E
2443 C
2444 E
2445 C
2446 C
2447 D
2448 C
2449 D
2450 C
2451 D
2452 C
2453 E
2454 C
2455 C
2456 C
2457 E
2458 C
2459 E
2460 E
2461 C
2462 C
2463 E
2464 C
2465 D
2466 E
2467 C
2468 E
2469 C
2470 C
2471 D
2472 C
2473 E
2474 C
2475 D
2476 C
2477 E
2478 C
2479 E
2480 D
2481 C
2482 C
2483 E
2484 E
2485 C
2486 E
2487 C
2488 C
2489 E
2490 E
2491 C
2492 E
2493 C
2494 C
2495 E
2496 C
2497 E
2498 E
2499 C
2500 E
2501 C
2502 C
2503 D
2504 D
2505 C
2506 C
2507 E
2508 E
2509 C
2510 C
2511 D
2512 C
2513 E
2514 E
2515 C
2516 C
2517 D
2518 E
2519 C
2520 E
2521 C
2522 E
2523 C
2524 B
另外，以C、D、或E之AC 50測試了以下化合物：
化合物 AC 50
1-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-3-(1,3-噻唑-2-基)丙-1-酮之4S及4R鏡像異構物 C、E
3-(5-甲基-1,3,4-噻二唑-2-基)-1-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]丙-1-酮之4S及4R鏡像異構物 D、E
5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、C
2-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-{4-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-{4-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
二甲基({3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)胺之4S及4R鏡像異構物 C、E
5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R之鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
1-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-2-{吡唑并[1,5-a]吡啶-3-基}乙-1-酮之4S及4R鏡像異構物 C、D
5-環丙烷羰基-4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
1-[4-{吡唑并[1,5-a]吡啶-2-基}-3H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-2-(1,3,4-噻二唑-2-基)乙-1-酮之4S及4R鏡像異構物 C、E
1-甲基-4-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}哌𠯤之4S及4R鏡像異構物 D、E
4-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 C、E
2-{4-環丙基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H,8H-咪唑并[4,5-c]氮呯-5-羰基]-1,3-㗁唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H,8H-咪唑并[4,5-c]氮呯-5-羰基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 D、E
5-[(1R)-2,2-二氟環丙烷羰基]-4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
5-[(1S)-2,2-二氟環丙烷羰基]-4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
4-氟-1-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}哌啶之4S及4R鏡像異構物 C、E
N,N-二甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-胺之4S及4R鏡像異構物 C、E
2-(3-氟吖呾-1基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
N-環丙基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-胺之4S及4R鏡像異構物 C、E
2-(甲氧基甲基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-噻唑之4S及4R鏡像異構物 C、D
2-(甲氧基甲基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
5'-(4-甲基-1,3-㗁唑-5-羰基)-4'-{吡唑并[1,5-a]吡啶-2-基}-1',4',5',6'-四氫螺[環丙烷-1,7'-咪唑并[4,5-c]吡啶]之4'S及4'R鏡像異構物 C、E
N-(2-甲氧基乙基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-胺之4S及4R鏡像異構物 D、D
二甲基({5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}甲基)胺之4S及4R鏡像異構物 D、E
3-(二氟甲基)-1-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、D
2-(甲氧基甲基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
5-(二氟甲基)-1-甲基-4-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、C
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}-5-(三氟甲基)吡啶之4S及4R鏡像異構物 C、D
2-(1H-吡唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吖呾-1-基}吡啶之4S及4R鏡像異構物 C、E
1-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
2-(2-氟丙-2-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吖呾-1-羧酸甲基酯之4S及4R鏡像異構物 D、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑-1-基}吡啶之4S及4R鏡像異構物 C、E
2-[1-(2,2-二氟乙基)-1H-吡唑-4-基]-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(3,3-二氟環丁基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-(2,2,2-三氟乙基)吖呾之4S及4R鏡像異構物 D、E
2-{5-氯-4-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑-1-基}吡啶之4S及4R鏡像異構物 C、D
2-(1H-吡唑-3-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-4-羧醯胺之4S及4R鏡像異構物 C、E
(1R)-1-{4-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
5-[4-{3-溴吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-4-甲腈之4S及4R鏡像異構物 C、C
(1S)-1-{4-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
2-[4-{3-溴吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
5-氯-4-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、C
5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 D、E
4-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 D、E
1-甲基-3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 D、E
1-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑-3-胺之4S及4R鏡像異構物 D、E
5-氯-4-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-(2,2,2-三氟乙基)-1H-吡唑之4S及4R鏡像異構物 C、E
(1S)-1-{5-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-(二氟甲基)-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
4-乙基-3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4H-1,2,4-三唑之4S及4R鏡像異構物 C、E
2-{5-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-(三氟甲基)-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 E、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,2-㗁唑-3-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,2-㗁唑-5-基}丙-2-醇之4S及4R鏡像異構物 D、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,2,4-㗁二唑-3-基}丙-2-醇之4S及4R鏡像異構物 D、E
(1S)-1-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-甲基-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
2-{3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,2,4-㗁二唑-5-基}丙-2-醇之4S及4R鏡像異構物 D、E
(1S)-1-[4-(二氟甲基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基]乙-1-醇之4S及4R鏡像異構物 C、E
4-(二氟甲基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
5-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-(二氟甲基)-1,3-㗁唑之4S及4R鏡像異構物 C、E
5-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-(三氟甲基)-1,3-㗁唑之4S及4R鏡像異構物 E、E
4-(二氟甲基)-5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-[4-(二氟甲基)-5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基]丙-2-醇之4S及4R鏡像異構物 D、E
5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-(三氟甲基)-1,3-㗁唑之4S及4R鏡像異構物 E、E
1-(二氟甲基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、E
2-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-(三氟甲基)-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 E、E
2-{5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-4-基)-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-3-基)-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
4-(二氟甲基)-5-[4-{6-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-咪唑-5-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-(二氟甲基)-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基]丙-2-醇之4S及4R鏡像異構物 E、E
2-(1-甲基-1H-咪唑-5-基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-4-基)-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-3-基)-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-(三氟甲基)-1H-吡唑之4S及4R鏡像異構物 E、E
2-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-(三氟甲基)-1H-吡唑之4S及4R鏡像異構物 E、E
2-[4-(二氟甲基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基]吡啶之4S及4R鏡像異構物 C、E
4-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 C、E
1-甲基-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 E、E
5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-(丙-2-基)-1H-吡唑之4S及4R鏡像異構物 E、E
1-環丙基-5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 E、E
4-(二氟甲基)-2-(1-甲基-1H-吡唑-3-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 D、E
4-(二氟甲基)-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-2-(1-甲基-1H-吡唑-3-基)-1,3-㗁唑之4S及4R鏡像異構物 D、E
4-(二氟甲基)-2-(1-甲基-1H-吡唑-3-基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
4-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 C、D
5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-二甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
4-(二氟甲基)-2-(1-甲基-1H-吡唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 E、E
5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-(丙-2-基)-1H-吡唑之4S及4R鏡像異構物 E、E
3-三級丁基-1-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、C
3-三級丁基-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-吡唑之4S及4R鏡像異構物 C、D
3-三級丁基-1-甲基-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、D
1-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}-4-甲基哌𠯤之4S及4R鏡像異構物 C、E
1,3-二甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-吡唑之4S及4R鏡像異構物 E、E
3-三級丁基-5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-吡唑之4S及4R鏡像異構物 C、D
4-(二氟甲基)-2-(1-甲基-1H-咪唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 E、E
2-{3-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑-1-基}吡啶之4S及4R鏡像異構物 C、C
2-{3-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑-1-基}吡啶之4S及4R鏡像異構物 C、D
1-甲基-4-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}哌𠯤之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-咪唑-5-基)-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-咪唑-5-基)-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[-4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-(1-甲基-1H-咪唑-5-基)-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
1-(二氟甲基)-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-吡唑之4S及4R鏡像異構物 C、E
2-甲基-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(2-氟丙-2-基)-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-{5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、D
3-(二氟甲基)-5-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
3-環丙基-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
3-(二氟甲基)-1-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
1-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、D
1-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-3-(三氟甲基)-1H-1,2,4-三唑之4S及4R鏡像異構物 C、D
3-(二氟甲基)-5-[4-{6-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
4-(2,2-二氟乙基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
3-環丙基-1-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
1,3-二甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
2-{5-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-咪唑-5-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-[4-{6-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 D、E
2-三級丁基-5-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
4-(二氟甲基)-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-{5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、C
2-{5-[4-{6-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-(2-氟丙-2-基)-5-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-{5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、C
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-甲基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1-甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 C、C
2-甲基-5-[4-[6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-環丙基-5-[4-[6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-[6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-[6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-環丙基-5-[4-{5-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-(1-甲基-1H-吡唑-4-基)-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-環丙基-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-環丙基-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-3-環丙基-1-甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-二甲基-1H-1,2,4-三唑之4S及4R鏡像異構物 D、E
3-(二氟甲基)-1-甲基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
1,3-二甲基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、D
2-(1-甲基-1H-吡唑-3-基)-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-甲基-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、C
2-{5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、D
5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、C
2-甲基-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-(2-氟丙-2-基)-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
5-[4-{5-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
5-[4-[6-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-(2-氟丙-2-基)-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 D、E
2-三級丁基-5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{4-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
(1S)-1-{4-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
(1R)-1-{4-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
2-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-{5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 D、E
2-三級丁基-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-甲基-5-[4-{6-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{6-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 D、E
5-[4-[5-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、D
5-[4-{6-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
(1R)-1-{5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-4-甲基-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、D
2-{5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{4-甲基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、C
(1R)-1-{4-甲基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
2-{5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-(1,5-二甲基-1H-吡唑-4-基)-5-[4-{3-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
(1S)-1-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
1-甲基-3-(三氟甲基)-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1H-1,2,4-三唑之4S及4R鏡像異構物 C、E
(1R)-1-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}乙-1-醇之4S及4R鏡像異構物 C、E
2-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-環丙基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-5-{吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
5-{吡唑并[1,5-a]吡啶-3-羰基}-4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-{5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、D
1-甲基-4-{3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}-1H-吡唑之4S及4R鏡像異構物 C、C
4-{3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基} 啉之4S及4R鏡像異構物 C、D
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(丙-2-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-{5-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}丙-2-醇之4S及4R鏡像異構物 C、E
2-{5-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-(丙-2-基)-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、C
2-環丙基-5-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-[1-(三氟甲基)-1H-吡唑-4-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-(3,3-二氟環丁基)-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(3,3-二氟環丁基)-5-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-環丙基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-咪唑-5-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-咪唑-5-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(3,3-二氟環丁基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-(3,3-二氟環丁基)-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-環丙基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-環丙基-5-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-咪唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(3,3-二氟環丁基)-5-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-環丙基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
N,N-二甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-羧醯胺之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-3H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3-苯并㗁唑之4S及4R鏡像異構物 C、E
({3-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)二甲胺之4S及4R鏡像異構物 C、E
2-{5-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-N,N-二甲基-1,3,4-㗁二唑-2-羧醯胺之4S及4R鏡像異構物 C、E
N,N-二甲基-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-羧醯胺之4S及4R鏡像異構物 C、E
二甲基({3-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)胺之4S及4R鏡像異構物 C、E
5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1-甲基-1H-吡唑-3-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
({3-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)二甲胺之4S及4R鏡像異構物 C、E
({3-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)二甲胺之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
4-{3-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基} 啉之4S及4R鏡像異構物 C、E
4-{3-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基} 啉之4S及4R鏡像異構物 C、E
3-氟-2-{5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 D、E
4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
4-{3-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基} 啉之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
4-{7-氯吡唑并[1,5-a]吡啶-2-基}-5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、D
5-{6-甲氧基吡唑并[1,5-a]吡啶-3-羰基}-4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
({3-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)二甲胺之4S及4R鏡像異構物 C、E
({3-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)二甲胺之4S及4R鏡像異構物 C、D
4-{3-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基} 啉之4S及4R鏡像異構物 D、E
4-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 D、E
4-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 C、E
4-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-4-基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
4-{7-氟吡唑并[1,5-a]吡啶-2-基}-5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
2-甲基-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3-苯并㗁唑之4S及4R鏡像異構物 D、E
2-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶之4S及4R鏡像異構物 C、D
2-[5-{6-甲基吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-4-基]-7-(三氟甲基)吡唑并[1,5-a]吡啶之4S及4R鏡像異構物 C、E
7-(二氟甲基)-2-[5-{6-甲基吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-4-基]吡唑并[1,5-a]吡啶之4S及4R鏡像異構物 C、E
5-{6-環丙基吡唑并[1,5-a]吡啶-3-羰基}-4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-5-{6-甲氧基吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、D
2-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-[1-(三氟甲基)-1H-吡唑-4-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-N,N-二甲基-1,3,4-㗁二唑-2-羧醯胺之4S及4R鏡像異構物 C、E
N,N-二甲基-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-羧醯胺之4S及4R鏡像異構物 C、E
2-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶之4S及4R鏡像異構物 C、E
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
5-{6-環丙基吡唑并[1,5-a]吡啶-3-羰基}-4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、D
4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-5-{6-甲氧基吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、D
2-[4-[4-(三氟甲氧基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-[1-(三氟甲基)-1H-吡唑-4-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
7-(二氟甲基)-2-[5-{吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-4-基]吡唑并[1,5-a]吡啶之4S及4R鏡像異構物 C、E
5-[6-(甲氧基甲基)吡唑并[1,5-a]吡啶-3-羰基]-4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
({3-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}甲基)二甲胺之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3-苯并㗁唑之4S及4R鏡像異構物 D、D
4-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 D、E
2-(1-甲基-1H-吡唑-4-基)-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-甲基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-甲基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
4-{3-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}-1-甲基-1H-吡唑之4S及4R鏡像異構物 C、D
2-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶之4S及4R鏡像異構物 C、C
2-(二氟甲基)-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-環丙基-5-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
7-甲基-2-[5-{6-甲基吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-4-基]吡唑并[1,5-a]吡啶之4S及4R鏡像異構物 C、D
3-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-N,N-二甲基吡唑并[1,5-a]吡啶-6-胺之4S及4R鏡像異構物 C、D
5-[6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-羰基]-4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 C、E
4-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基} 啉之4S及4R鏡像異構物 D、E
2-(二氟甲基)-5-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(二氟甲基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
7-氯-2-[5-{6-甲基吡唑并[1,5-a]吡啶-3-羰基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-4-基]吡唑并[1,5-a]吡啶之4S及4R鏡像異構物 C、D
2-三級丁基-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶-5-胺之4S及4R鏡像異構物 C、E
5-[6-(2-甲氧基乙基)吡唑并[1,5-a]吡啶-3-羰基]-4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R之鏡像異構物 D、E
2-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
3-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-N,N-二甲基吡唑并[1,5-a]吡啶-6-胺之4S及4R鏡像異構物 C、E
(2-{3-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}乙基)二甲胺之4S及4R鏡像異構物 C、E
二甲基(2-{3-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}乙基)胺之4S及4R鏡像異構物 C、E
2-環丁基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-環丁基-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
6-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]吡啶-3-胺之4S及4R鏡像異構物 D、E
3-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-N,N-二甲基吡唑并[1,5-a]吡啶-6-胺之4S及4R鏡像異構物 C、E
2-環丁基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶-5-胺之4S及4R鏡像異構物 D、E
2-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶-5-胺之4S及4R鏡像異構物 D、E
2-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶-5-胺之4S及4R鏡像異構物 D、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-噻唑之4S及4R鏡像異構物 C、E
6-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]吡啶-3-胺之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(1-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
二甲基(2-{3-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}乙基)胺之4S及4R鏡像異構物 D、E
二甲基(2-{3-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]吡唑并[1,5-a]吡啶-6-基}乙基)胺之4S及4R鏡像異構物 C、D
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-環丁基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-環丁基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-環丁基-5-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-三級丁基-5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-[4-{7-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(三氟甲基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-三級丁基-5-[4-[7-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、D
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶-5-胺之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-(1-甲基-1H-吡唑-3-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、D
2-(1,5-二甲基-1H-吡唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、D
2-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 D、E
2-甲基-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-噻二唑之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-甲基-1,3,4-噻二唑之4S及4R鏡像異構物 C、E
2-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-苯并噻唑之4S及4R鏡像異構物 C、E
5-環丙烷羰基-4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 D、E
2-氟-6-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}嘧啶之4S及4R鏡像異構物 D、D
2-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}嘧啶之4S及4R鏡像異構物 D、E
2-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
4-環丙基-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、D
4-環丙基-2-(1-甲基-1H-吡唑-4-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑之4S及4R鏡像異構物 C、D
5-環丁烷羰基-4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 D、E
5-環丁烷羰基-4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶之4S及4R鏡像異構物 D、E
5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-2-(1-甲基-1H-吡唑-3-基)-1,3-㗁唑之4S及4R鏡像異構物 C、E
5-(三氟甲基)-2-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]吡啶之4S及4R鏡像異構物 C、E
5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-2-(1-甲基-1H-吡唑-4-基)-1,3-㗁唑之4S及4R鏡像異構物 C、D
5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-2-(1-甲基-1H-吡唑-4-基)-1,3-㗁唑之4S及4R鏡像異構物 C、E
2-[4-[4-(二氟甲氧基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、E
4-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、D
4-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、D
2-(1-甲基環丙基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、E
4-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 E、E
4-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、D
3-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嗒𠯤之4S及4R鏡像異構物 C、E
3-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嗒𠯤之4S及4R鏡像異構物 C、E
3-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嗒𠯤之4S及4R鏡像異構物 C、E
3-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嗒𠯤之4S及4R鏡像異構物 C、E
3-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-[4-{4-甲氧基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-甲基-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(1-甲基環丙基)-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(2-氟丙-2-基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(2-氟丙-2-基)-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(2-氟丙-2-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(3,3-二氟環丁基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(3,3-二氟環丁基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
3-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嗒𠯤之4S及4R鏡像異構物 C、E
3-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嗒𠯤之4S及4R鏡像異構物 C、E
4-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1-甲基-1H-吡唑之4S及4R鏡像異構物 C、E
2-[4-[4-(丙-2-基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]嘧啶之4S及4R鏡像異構物 E、E
2-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(1-甲基環丙基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(2-氟丙-2-基)-5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(3,3-二氟環丁基)-5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(3,3-二氟環丁基)-5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-(3,3-二氟環丁基)-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(3,3-二氟環丁基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(丙-2-基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}嘧啶之4S及4R鏡像異構物 C、E
2-{5-[4-{7-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、E
2-{5-[4-{7-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、D
3-{5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
3-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-甲基-3-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3-㗁唑-2-基}吡𠯤之4S及4R鏡像異構物 C、D
1-甲基-4-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1H-吡唑之4S及4R鏡像異構物 D、E
2-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(3,3-二氟環丁基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-{5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡𠯤之4S及4R鏡像異構物 C、E
3-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
3-{5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
3-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}-2-甲基吡啶之4S及4R鏡像異構物 C、C
1-甲基-4-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1H-吡唑之4S及4R鏡像異構物 C、E
2-(2-氟丙-2-基)-5-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
3-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-氟-3-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-(3-甲基-1H-吡唑-4-基)-5-[4-{4-甲基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{4-氟吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基]-5-(3-甲基-1H-吡唑-4-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-氟-3-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
3-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}-2-氟吡啶之4S及4R鏡像異構物 C、D
2-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(2-氟丙-2-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(2-氟丙-2-基)-5-[4-[4-(丙-2-基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
2-[4-{4-氯吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(2-氟丙-2-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
3-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}-2-氟吡啶之4S及4R鏡像異構物 C、D
2-[4-[4-(丙-2-基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]吡𠯤之4S及4R鏡像異構物 D、E
2-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-5-(丙-2-基)-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(丙-2-基)-5-[4-[4-(丙-2-基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 D、E
2-(1,1-二氟乙基)-5-[4-[7-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑之4S及4R鏡像異構物 C、E
3-氟-2-{5-[4-[4-(三氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-[4-(二氟甲基)吡唑并[1,5-a]吡啶-2-基]-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}-3-氟吡啶之4S及4R鏡像異構物 C、E
2-{5-[4-{4-環丙基吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}-3-氟吡啶之4S及4R鏡像異構物 C、D
2-氟-6-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、E
5-氟-2-{5-[4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-基]-1,3,4-㗁二唑-2-基}吡啶之4S及4R鏡像異構物 C、D
2-[2-(3-氟吖呾-1-基)乙基]-5-(4-{吡唑并[1,5-a]吡啶-2-基}-1H,4H,5H,6H,7H-咪唑并[4,5-c]吡啶-5-羰基)-1,3,4-㗁二唑 D
現在已經全面描述了本文提供之方法、化合物及物質組成物，所屬技術領域中具有通常知識者將理解，在不影響本文提供之方法、化合物及組成物或其任何實施例之範疇的情況下，可以在廣泛及等效的條件、配方及其他參數範圍內進行相同的操作。
本文所引用之所有專利、專利申請案、及出版物之全文皆以引用方式完全併入本文中。
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Claims (96)

  1. 一種式 I之化合物： I或其醫藥上可接受之鹽，其中： m係1或2； R 1係 ； x係0至5； 各R a獨立地係鹵基、C 1-6烷基、C 3-6環烷基、C 1-6鹵烷基、C 1-6烷氧基、或C 1-6鹵烷氧基； R 2係C 1-4烷基、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、或可選地經取代之雜芳基； R 3係H或C 1-6烷基； R 4係H或C 1-6烷基； 或R 3及R 4與其等所附接之原子一起形成C 3-6環烷基； R 5係H或D； R 5A係H或D； L係鍵、羰基、可選地經取代之C 1-6伸烷基、可選地經取代之C 1-6伸烷基羰基、可選地經取代之C 2-6伸烯基羰基、可選地經取代之C 1-6鹵伸烷基羰基、或可選地經取代之-C(O)NR b(C 1-6伸烷基)-，其中該羰基之碳原子係連接至式 I中之N；且 R b係H或C 1-6烷基。
  2. 如請求項1之化合物或其醫藥上可接受之鹽，其中R 5A係D。
  3. 如請求項1之化合物或其醫藥上可接受之鹽，其中R 5A係H。
  4. 如請求項1之化合物，其中該化合物具有式 I-A： I-A諸如 I-A-1或 I-A-2、或其醫藥上可接受之鹽。
  5. 如請求項1之化合物，其中該化合物具有式 I-B： I-B諸如 I-B-1或 I-B-2、或其醫藥上可接受之鹽。
  6. 如請求項1之化合物，其中該化合物具有式 I-C： I-C諸如 I-C-1或 I-C-2、或其醫藥上可接受之鹽。
  7. 如請求項1之化合物，其中該化合物具有式 I-D： I-D諸如 I-D-1或 I-D-2、或其醫藥上可接受之鹽。
  8. 如請求項1之化合物，其中該化合物具有式 I-E： I-E諸如 I-E-1或 I-E-2、或其醫藥上可接受之鹽。
  9. 如請求項1至4中任一項之化合物或其醫藥上可接受之鹽，其中L係鍵、-C(O)-、-C(O)CH 2-、-C(O)CH 2CH 2-、-C(O)CH 2CH 2CH 2-、 -C(O)CF 2-、-C(O)CHF-、-C(O)C(CH 3) 2-、-C(O)CH=CH-、 、-C(O)NHCH 2-、-CH 2-、或-CH 2CH 2-。
  10. 如請求項9之化合物或其醫藥上可接受之鹽，其中L係鍵、-C(O)-、-C(O)CH 2-、或-C(O)CF 2-。
  11. 如請求項1至3及9至10中任一項之化合物或其醫藥上可接受之鹽，其中R 3及R 4各自係氫。
  12. 如請求項1至11中任一項之化合物或其醫藥上可接受之鹽，其中m係1。
  13. 如請求項1至11中任一項之化合物或其醫藥上可接受之鹽，其中m係2。
  14. 如請求項1至13中任一項之化合物或其醫藥上可接受之鹽，其中x係0或1。
  15. 如請求項1至14中任一項之化合物或其醫藥上可接受之鹽，其中R 1係 、 、 、 、 、或 。
  16. 如請求項1至15中任一項之化合物或其醫藥上可接受之鹽，其中R a係鹵基，諸如F、Br、或Cl。
  17. 如請求項1至15中任一項之化合物或其醫藥上可接受之鹽，其中R a係C 1-6烷基，諸如甲基、乙基、或異丙基。
  18. 如請求項1至15中任一項之化合物或其醫藥上可接受之鹽，其中R a係C 1-6烷氧基，諸如甲氧基或乙氧基。
  19. 如請求項1至15中任一項之化合物或其醫藥上可接受之鹽，其中R a係C 1-6鹵烷基，諸如CF 3或CHF 2。
  20. 如請求項1至15中任一項之化合物或其醫藥上可接受之鹽，其中R a係C 1-6鹵烷氧基，諸如OCF 3或OCHF 2。
  21. 如請求項1至15中任一項之化合物或其醫藥上可接受之鹽，其中R a係C 3-6環烷基，諸如環丙基。
  22. 如請求項1至21中任一項之化合物或其醫藥上可接受之鹽，其中R 5係D。
  23. 如請求項1至21中任一項之化合物或其醫藥上可接受之鹽，其中R 5係H。
  24. 如請求項1至23中任一項之化合物或其醫藥上可接受之鹽，其中R 2係可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、或可選地經取代之雜芳基。
  25. 如請求項24之化合物或其醫藥上可接受之鹽，其中R 2係環戊基、環丁基、環丙基、環己基、吖呾基、苯基、吡唑基、㗁唑基、噻唑基、三唑基、㗁二唑基、吡啶基、嘧啶基、吡唑并[1,5-a]吡啶基、吲唑基、噻二唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2-b]嗒𠯤基、苯硫基、異㗁唑基、異噻唑基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、苯并[c]異㗁唑基、苯并[d]異噻唑基、呋喃基、吡𠯤基、或喹啉基，其中之各者可選地經取代。
  26. 如請求項24之化合物或其醫藥上可接受之鹽，其中R 2係環戊基、環丁基、環丙基、環己基、吖呾基、苯基、吡唑基、㗁唑基、噻唑基、三唑基、㗁二唑基、吡啶基、嘧啶基、吡唑并[1,5-a]吡啶基、吲唑基、噻二唑基、咪唑[1,5-a]吡啶基、吡咯并[1,2]嗒𠯤基、苯硫基、異㗁唑基、異噻唑基、苯并[d]噻唑基、苯并[d]咪唑基、苯并[d]㗁唑基、苯并[d]異㗁唑基、苯并[c]異㗁唑基、苯并[d]異噻唑基、呋喃基、吡𠯤基、或喹啉基，其中之各者未經取代。
  27. 如請求項24之化合物或其醫藥上可接受之鹽，其中R 2係吖呾-1-基、吖呾-3-基、吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、1,2,4-三唑-1-基、1,2,4-三唑-3-基、1,2,4-三唑-5-基、1,2,3-三唑-5-基、1,3,4-㗁二唑-2-基、1,2,4-㗁二唑-3-基、1,2,4-㗁二唑-5-基、吡唑并[1,5-a]吡啶-3-基、吲唑-3-基、噻唑-2-基、噻唑-4-基、噻唑-5-基、㗁唑-2-基、㗁唑-4-基、㗁唑-5-基、1,3,4-噻二唑-2-基、吡啶-1-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、嘧啶-2-基、咪唑[1,5-a]吡啶-1-基、吡咯并[1,2-b]嗒𠯤-5-基、吡咯并[1,2-b]嗒𠯤-6-基、苯硫-2-基、異㗁唑-3-基、異㗁唑-4-基、異㗁唑-5-基、苯并[d]噻唑-2-基、苯并[d]噻唑-3-基、苯并[d]咪唑-2-基、苯并[d]㗁唑-2-基、苯并[d]異㗁唑-3-基、苯并[d]異噻唑-3-基、呋喃-3-基、異噻唑-3-基、異噻唑-4-基、異噻唑-5-基、吡𠯤-2-基、苯并[c]異㗁唑-3-基、或喹啉-3-基，其中之各者可選地經取代。
  28. 如請求項24、25、及27中任一項之化合物或其醫藥上可接受之鹽，其中R 2經下列中之一或多者取代： C 1-6烷基，諸如甲基、乙基、丙基、異丙基、或三級丁基； 可選地經取代之C 2-6烯基，諸如CH=CH 2、CH=CHC(CH 3) 2OH、或CH=CH-環丙基； 鹵基，諸如Br、Cl、或F； CN； C 1-6氰烷基，諸如C(CH 3) 2CN； C 1-6鹵烷基，諸如CF 3、CHF 2、CH 2F、CH(CH 3)F、CH 2CF 3、C(CH 3) 2F、C(CH 3)F 2、或CH 2CHF 2； OH； 可選地經取代之C 3-8環烷基，諸如可選地經取代之環丙基、可選地經取代之環丁基、可選地經取代之環戊基、或可選地經取代之環己基； 可選地經取代之C 3-8環烷基(伸烷基)，諸如可選地經取代之環丙基(伸烷基)或可選地經取代之環丁基(伸烷基)； 可選地經取代之C 3-8環烯基，諸如可選地經取代之環己烯基； 可選地經取代之芳基，諸如可選地經取代之苯基； 可選地經取代之芳基(伸烷基)，諸如可選地經取代之苄基； 可選地經取代之雜芳基，諸如可選地經取代之吡唑基、可選地經取代之咪唑基、可選地經取代之吡啶基、可選地經取代之嘧啶基、可選地經取代之吡𠯤基、或可選地經取代之嗒𠯤基； 可選地經取代之雜環基，諸如可選地經取代之吖呾基、可選地經取代之哌啶基、可選地經取代之哌𠯤基、可選地經取代之吡咯啶基、可選地經取代之 啉基、或可選地經取代之6-氮雜螺[2.5]辛-6-基； 可選地經取代之雜環基(伸烷基)，諸如可選地經取代之 啉基(伸烷基)、哌啶基(伸烷基)、可選地經取代之哌𠯤基(伸烷基)、或可選地經取代之吖呾基(伸烷基)； C 1-6羥基烷基，諸如C(CH 3) 2OH、CH(CH 3)OH、C(CH 3) 2CH 2OH、CH 2C(CH 3) 2OH、或CH(CH 2CH 3)OH； C 1-6鹵烷氧基，諸如OCF 3、OCH 2CF 3、或OCH 2CH 2CF 3； C 1-6鹵烷氧基(伸烷基)，諸如CH 2OCF 3； C 1-6烷氧基，諸如甲氧基或乙氧基； C 1-6烷氧基(伸烷基)，諸如C(CH 3) 2OCH 3、CH 2OCH 3、或(CH 2) 2OCH 3； C 1-6氘化烷氧基(伸烷基)，諸如CH 2OCD 3； C 1-6烷基羰基，諸如C(=O)CH 3或CH 2C(=O)CH 3； C 3-8環烷基磺醯基，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基； C 1-6烷基磺醯基，諸如甲磺醯基、乙磺醯基、或丙磺醯基； C 1-6烷基磺醯基(伸烷基)，諸如C(CH 3) 2SO 2CH 3； (CR vR x) pNR yR z，其中R v及R x獨立地係H或C 1-6烷基；R y及R z獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6羥基烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、或C(O)OC 1- 6烷基；且p係0、1、2、或3，諸如NH 2、NH環丙基、NHCH 3、N(CH 3) 2、CH 2N(CH 3) 2、(CH 2) 2N(CH 3) 2、CH 2N(CH 3)(CH 2CH 3)、C(CH 3) 2NH(CH 3)、C(CH 3) 2N(CH 3) 2、CH 2N(CH 3)環丁基、或CH 2N(CH 3)(C(O)O三級丁基)；及 C(O)NR y2R z2，其中R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基，諸如C(O)N(CH 3) 2或C(O)NH環丙基。
  29. 如請求項24之化合物或其醫藥上可接受之鹽，其中R 2係雜環基，其可選地經鹵基、C 1-6鹵烷基、或可選地經取代之雜芳基中之一或多者取代。
  30. 如請求項24之化合物或其醫藥上可接受之鹽，其中R 2係C 3-8環烷基，其可選地經鹵基、C 1-6烷基、C 1-6鹵烷基、或OH中之一或多者取代。
  31. 如請求項30之化合物或其醫藥上可接受之鹽，其中R 2係未經取代之環丙基、未經取代之環丁基、未經取代之環戊基、未經取代之環己基、 、 、 、 、 、 、或 。
  32. 如請求項24之化合物或其醫藥上可接受之鹽，其中R 2係芳基，其可選地經鹵基或C 1-6烷氧基中之一或多者取代。
  33. 如請求項25之化合物或其醫藥上可接受之鹽，其中R 2係可選地經取代之吡啶基、可選地經取代之嘧啶基、或可選地經取代之吡𠯤基。
  34. 如請求項33之化合物或其醫藥上可接受之鹽，其中該吡啶基、該嘧啶基、或該吡𠯤基經下列中之一或多者取代：鹵基、C 1-6鹵烷基、氰基、或NR yR z，其中R y及R z獨立地係H或C 1-6烷基。
  35. 如請求項24、25、及27中任一項之化合物或其醫藥上可接受之鹽，其中R 2係雜芳基，其經C 1-6烷基、C 1-6氰烷基、C 1-6鹵烷基、或C 1-6羥基烷基中之一或多者取代。
  36. 如請求項35之化合物或其醫藥上可接受之鹽，其中R 2經甲基、乙基、異丙基、三級丁基、C(CH 3) 2CN、CH(CH 3)OH、C(CH 3) 2OH、C(CH 3) 2CH 2OH、CH(CH 2CH 3)OH、CH 2C(CH 3) 2OH、CH 2F、CHF 2、CF 3、CH 2CF 3、CH 2CHF 2、CH(CH 3)F、C(CH 3)F 2、或C(CH 3) 2F取代。
  37. 如請求項24、25、及27中任一項之化合物或其醫藥上可接受之鹽，其中R 2係雜芳基，其經C 3-8環烷基取代，諸如環丙基、環丁基、環戊基、或環己基，其中該C 3-8環烷基可選地經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；OH；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；或C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基。
  38. 如請求項37之化合物或其醫藥上可接受之鹽，其中R 2經 、 、 、 、 、 、 、或 取代。
  39. 如請求項24、25、及27中任一項之化合物或其醫藥上可接受之鹽，其中R 2係雜芳基，其經芳基取代，諸如苯基，其中該芳基可選地經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；或C 3-8環烷基，諸如環丙基、環丁基、或環戊基。
  40. 如請求項39之化合物或其醫藥上可接受之鹽，其中R 2經 、 、 、 、 、 、 、 、 、 、 、 、或 取代。
  41. 如請求項28之化合物或其醫藥上可接受之鹽，其中R 2係雜芳基，其經可選地經取代之雜芳基取代，其中該可選取代係下列中之一或多者： 鹵基，諸如F、Cl、或Br； C 1-6鹵烷基，諸如CF 3、CH 2CHF 2、CH 2CF 3、或CHF 2； C 1-6烷基，諸如甲基、乙基、丙基、或異丙基； C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基； C 1-6鹵烷氧基，諸如OCF 3； C 3-8環烷基，諸如環丙基、環丁基、或環戊基；或 C 3-8環烷基磺醯基，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。
  42. 如請求項41之化合物或其醫藥上可接受之鹽，其中R 2經吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、嘧啶-2-基、嘧啶-4-基、嘧啶-5-基、吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、吡𠯤-5-基、咪唑-4-基、咪唑-5-基、嗒𠯤-3-基、或嗒𠯤-4-基取代，其中之各者可選地經取代。
  43. 如請求項42之化合物或其醫藥上可接受之鹽，其中R 2經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。
  44. 如請求項42之化合物或其醫藥上可接受之鹽，其中R 2經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。
  45. 如請求項24、25、或27中任一項之化合物或其醫藥上可接受之鹽，其中R 2係雜芳基，其經下列取代：可選地經取代之雜環基，諸如可選地經取代之吖呾基、可選地經取代之吡咯啶基、可選地經取代之哌啶基、可選地經取代之哌𠯤基、可選地經取代之 啉基、或可選地經取代之6-氮雜螺[2.5]辛-6-基；或可選地經取代之雜環基(伸烷基)，其中該可選取代係下列中之一或多者： 鹵基，諸如F、Cl、或Br； OH； C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2； C 1-6烷基，諸如甲基、乙基、或丙基； C 1-6羥基烷基，諸如C(CH 3) 2OH或CH(CH 3)OH； C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基； C(O)O(C 1-6烷基)，諸如C(O)O甲基、C(O)O乙基、C(O)O丙基、或C(O)O三級丁基；或 C 3-8環烷基，諸如環丙基、環丁基、或環戊基。
  46. 如請求項45之化合物或其醫藥上可接受之鹽，其中R 2經 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 取代。
  47. 如請求項1至23中任一項之化合物或其醫藥上可接受之鹽，其中R 2係： 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 ； 其中： R 6及R 7獨立地係H、CN、C 1-6烷基、C 1-6鹵烷基、C 1-6氰烷基、C 1-6羥基烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 1-6氘化烷氧基(伸烷基)、鹵基、(CR vR x) pNR yR z、C(O)NR y2R z2、C 1-6烷基羰基、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之芳基、可選地經取代之雜芳基、可選地經取代之C 2-6烯基；可選地經取代之C 3-8環烯基；可選地經取代之C 3-8環烷基(伸烷基)；可選地經取代之芳基(伸烷基)；可選地經取代之雜環基(伸烷基)；或C 1-6烷基磺醯基； R 8係H、C 1-6烷基、C 1-6鹵烷基、C 1-6烷氧基、C 1-6烷基羰基、C 1-6羥基烷基、(CR vR x) pNR yR z 、可選地經取代之C 3-8環烷基、可選地經取代之芳基、可選地經取代之雜芳基、或可選地經取代之C 3-8環烷基(伸烷基)； R v及R x獨立地係H或C 1-6烷基； R y及R z獨立地係H、C 1-6烷基、C 1-6烷氧基(伸烷基)、或C 3-6環烷基； R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基；且 p係0、1、2、或3。
  48. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 6、R 7、及R 8各自係H。
  49. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 6係C 1-6烷基，諸如甲基、乙基、異丙基、或三級丁基；C 1-6鹵烷基，諸如CF 3、CHF 2、CH 2F、CH 2CF 3、CH(CH 3)F、C(CH 3)F 2、或C(CH 3) 2F；C 1-6氰烷基，諸如C(CH 3) 2CN；或C 1-6羥基烷基，諸如C(CH 3) 2OH、CH(CH 3)OH、CH(CH 2CH 3)OH、CH 2C(CH 3) 2OH、或C(CH 3) 2CH 2OH。
  50. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 6係C 3-6環烷基，諸如環丙基、環丁基、環戊基、或環己基，其可選地經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；OH；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；或C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基。
  51. 如請求項50之化合物或其醫藥上可接受之鹽，其中R 6係 、 、 、 、 、 、 、或 。
  52. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 6係芳基，諸如苯基，其可選地經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；或C 3-6環烷基，諸如環丙基、環丁基、或環戊基。
  53. 如請求項52之化合物或其醫藥上可接受之鹽，其中R 6係 、 、 、 、 、 、 、 、 、 、 、 、或 。
  54. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 6係雜芳基，諸如吡啶基、吡唑基、吡𠯤基、嗒𠯤基、咪唑基、或嘧啶基，其可選地經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、CH 2CHF 2、或CHF 2；C 1-6烷基，諸如甲基、乙基、丙基、或異丙基；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；C 1-6鹵烷氧基，諸如OCF 3；C 3-6環烷基，諸如環丙基、環丁基、或環戊基；或C 3-6環烷基磺醯基，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。
  55. 如請求項54之化合物或其醫藥上可接受之鹽，其中該雜芳基係吡唑-1-基、吡唑-3-基、吡唑-4-基、吡唑-5-基、吡啶-2-基、吡啶-3-基、吡啶-4-基、咪唑-4-基、咪唑-5-基、嘧啶-2-基、嘧啶-4-基、嘧啶-5-基、吡𠯤-2-基、吡𠯤-3-基、吡𠯤-4-基、吡𠯤-5-基、嗒𠯤-3-基、或嗒𠯤-4-基，其中之各者可選地經取代。
  56. 如請求項55之化合物或其醫藥上可接受之鹽，其中R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
  57. 如請求項55之化合物或其醫藥上可接受之鹽，其中R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
  58. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 6係：雜環基，諸如吖呾基、吡咯啶基、哌啶基、哌𠯤基、或 啉基；或雜環基(伸烷基)，其中該雜環基及該雜環基(伸烷基)各自可選地經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；C 1-6羥基烷基，諸如C(CH 3) 2OH；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；C(O)O(C 1-6烷基)，諸如C(O)O甲基、C(O)O乙基、C(O)O丙基、或C(O)O三級丁基；或C 3-6環烷基，諸如環丙基、環丁基、或環戊基。
  59. 如請求項58之化合物或其醫藥上可接受之鹽，其中R 6係 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、或 。
  60. 如請求項47至59中任一項之化合物或其醫藥上可接受之鹽，其中R 7係：H；CN；C 1-6烷基，諸如甲基；C 1-6鹵烷基，諸如CF 3、CH 2F、CHF 2、CF 2(CH 3)、或CH 2CHF 2；鹵基，諸如Br或Cl；C 3-8環烷基，諸如環丙基；苯基；或吡啶基。
  61. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 2係： 其中： R 6係：H；C 1-6烷基，諸如甲基或三級丁基；C 1-6鹵烷基，諸如C(CH 3) 2F；C 1-6氰烷基，諸如C(CH 3) 2CN；C 1-6羥基烷基，諸如C(CH 3) 2OH或CH(CH 3)OH；可選地經取代之C 3-6環烷基，諸如 或 ；可選地經取代之雜芳基，諸如 、 、 、 、 、 、或 ；且 R 7係：H；CN；C 1-6烷基，諸如甲基；C 1-6鹵烷基，諸如CHF 2或CF 3；鹵基，諸如Br或Cl；或C 3-6環烷基，諸如環丙基。
  62. 如請求項61之化合物或其醫藥上可接受之鹽，其中該可選地經取代之雜芳基經一或多個C 1-6烷基取代，諸如甲基、乙基、或異丙基。
  63. 如請求項61之化合物或其醫藥上可接受之鹽，其中該可選地經取代之C 3-6環烷基經一或多個OH取代。
  64. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 2係： 其中： R 6係：H；C 1-6烷基，諸如三級丁基；C 1-6鹵烷基，諸如C(CH 3) 2F或C(CH 3)F 2；C 1-6羥基烷基，諸如C(CH 3) 2OH或CH(CH 3)OH；且 R 7係H。
  65. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 2係： 其中： R 6係：H；C 1-6烷基，諸如甲基、異丙基、或三級丁基；C 1-6鹵烷基，諸如CF 3、CHF 2、C(CH 3)F 2、或C(CH 3) 2F；C 1-6羥基烷基，諸如C(CH 3) 2OH或CH(CH 3)OH；可選地經取代之C 3-6環烷基，諸如 、 、 、或 ；可選地經取代之芳基，諸如 、 、 、 、 、 、或 ；可選地經取代之雜環基，諸如 或 ；或可選地經取代之雜芳基，諸如 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 。
  66. 如請求項65之化合物或其醫藥上可接受之鹽，其中該可選地經取代之雜芳基經下列中之一或多者取代：C 1-6烷基，諸如甲基、乙基、或異丙基；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；鹵基，諸如F；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；C 3-6環烷基，諸如環丙基或環丁基；或C 3-6環烷基磺醯基，諸如環丙基磺醯基、環丁基磺醯基、或環戊基磺醯基。
  67. 如請求項65之化合物或其醫藥上可接受之鹽，其中該可選地經取代之C 3-6環烷基及該可選地經取代之雜環基各自經下列中之一或多者取代：鹵基，諸如F；或C 1-6烷基，諸如甲基。
  68. 如請求項65之化合物或其醫藥上可接受之鹽，其中該可選地經取代之芳基經下列中之一或多者取代：鹵基，諸如F；C 1-6烷基，諸如甲基；或C 1-6鹵烷基，諸如CF 3。
  69. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 2係： 、 、或 其中： R 6及R 7獨立地係：H；鹵基，諸如Cl；C 1-6烷基，諸如甲基；C 1-6鹵烷基，諸如CHF 2或CF 3；或NR yR z，諸如NH 2；且 R 8係：H；C 1-6烷基，諸如甲基或異丙基；C 1-6鹵烷基，諸如CHF 2、CH 2CF 3、或CF 3；C 3-6環烷基，諸如環丙基；或雜芳基，諸如吡啶基。
  70. 如請求項47之化合物或其醫藥上可接受之鹽，其中R 2係： 其中： R 6係：H；C 1-6烷基，諸如甲基；鹵基，諸如Cl；C 1-6鹵烷基，諸如CHF 2或CF 3；或C 3-6環烷基，諸如環丙基；且 R 8係：H；或C 1-6烷基，諸如甲基。
  71. 如請求項70之化合物或其醫藥上可接受之鹽，其中R 6及R 7中之至少一者係H。
  72. 如請求項1至23中任一項之化合物或其醫藥上可接受之鹽，其中R 2係： 、 、 、 、 、或 其中： W係S或NR 15； W 1係S、O、或NR 15； R 10、R 11、R 12、R 13、及R 14獨立地係H、C 1-6烷基、C 1-6鹵烷基、C 1-6烷氧基、C 1-6烷氧基(伸烷基)、C 1-6羥基烷基、C 1-6鹵烷氧基、C 1-6鹵烷氧基(伸烷基)、C 2-6烯基、CN、鹵基、(CR vR x) pNR yR z、C(O)NR y2R z2、可選地經取代之C 3-8環烷基、可選地經取代之雜環基、可選地經取代之雜環基(伸烷基)、可選地經取代之芳基、或可選地經取代之雜芳基； R v及R x獨立地係H或C 1-6烷基； R y及R z獨立地係H、C 1-6烷基、C 3-6環烷基、C 1-6羥基烷基、C 1-6鹵烷基、C 1-6烷氧基(伸烷基)、或C(O)OC 1- 6烷基； R y2及R z2獨立地係H、C 1-6烷基、或C 3-6環烷基； p係0、1、2、或3；且 R 15係H或C 1-6烷基。
  73. 如請求項72之化合物或其醫藥上可接受之鹽，其中R 10、R 11、R 12、R 13、及R 14各自係H。
  74. 如請求項72之化合物或其醫藥上可接受之鹽，其中R 10、R 11、R 12、及R 13各自係H。
  75. 如請求項72之化合物或其醫藥上可接受之鹽，其中R 2係： 其中： R 10、R 11、R 12、R 13、及R 14獨立地係：H；C 1-6烷基，諸如甲基；C 3-6環烷基，諸如環丙基；C 1-6烷氧基，諸如甲氧基；C 1-6烷氧基(伸烷基)，諸如CH 2OCH 3或(CH 2) 2OCH 3；可選地經取代之雜環基，諸如 、 、 、或 ；可選地經取代之雜環基(伸烷基)，諸如 或 ；可選地經取代之雜芳基，諸如 、 、 、 、 、 、 、 、 、 、 、 、 、或 ；或(CR vR x) pNR yR z，諸如N(CH 3) 2、CH 2N(CH 3) 2、或CH 2CH 2N(CH 3) 2； R v及R x獨立地係H或C 1-6烷基； R y及R z獨立地係：H；C 1-6烷基，諸如甲基或乙基；C 3-6環烷基，諸如環丁基；或C(O)OC 1- 6烷基，諸如C(O)O-三級丁基；且 p係0、1、2、或3。
  76. 如請求項75之化合物或其醫藥上可接受之鹽，其中該可選地經取代之雜環基及該可選地經取代之雜環基(伸烷基)各自經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；C 1-6烷基，諸如甲基、乙基、或丙基；OH；C 1-6羥基烷基，諸如C(CH 3) 2OH；C 1-6烷氧基，諸如甲氧基、乙氧基、或丙氧基；或C 3-6環烷基，諸如環丙基、環丁基、或環戊基。
  77. 如請求項75之化合物或其醫藥上可接受之鹽，其中該可選地經取代之雜環基係 。
  78. 如請求項75之化合物或其醫藥上可接受之鹽，其中該可選地經取代之雜芳基經下列中之一或多者取代：鹵基，諸如F、Cl、或Br；C 1-6鹵烷基，諸如CF 3、CH 2CF 3、或CHF 2；或C 1-6烷基，諸如甲基、乙基、丙基、或異丙基。
  79. 如請求項78之化合物或其醫藥上可接受之鹽，其中該可選地經取代之雜芳基係經一個甲基取代之吡唑基。
  80. 如請求項75至79中任一項之化合物或其醫藥上可接受之鹽，其中R 10、R 13、及R 14各自係氫。
  81. 如請求項75至79中任一項之化合物或其醫藥上可接受之鹽，其中R 10、R 11、R 13、及R 14各自係氫。
  82. 如請求項1至81中任一項之化合物，其係S-鏡像異構物或其醫藥上可接受之鹽。
  83. 如請求項1之化合物，其係表1中之化合物或其醫藥上可接受之鹽。
  84. 如請求項83之化合物，其係S-鏡像異構物或其醫藥上可接受之鹽。
  85. 一種醫藥組成物，其包含如請求項1至84中任一項之化合物或其醫藥上可接受之鹽、及醫藥上可接受之賦形劑。
  86. 如請求項85之醫藥組成物，其進一步包含額外治療劑。
  87. 一種用於穩定突變PAH蛋白之方法，其包含使該蛋白質與如請求項1至84中任一項之化合物或其醫藥上可接受之鹽接觸。
  88. 如請求項87之方法，其中該突變PAH蛋白含有至少一個R408W、R261Q、R243Q、Y414C、L48S、A403V、I65T、R241C、L348V、R408Q、或V388M突變。
  89. 如請求項87之方法，其中該突變PAH蛋白含有至少一個R408W、Y414C、I65T、F39L、R408Q、L348V、R261Q、A300S、或L48S突變。
  90. 如請求項87之方法，其中該突變PAH蛋白含有至少一個R408W突變。
  91. 如請求項87之方法，其中該突變PAH蛋白含有兩個R408W突變。
  92. 一種用於降低罹患苯酮尿症之對象之血液苯丙胺酸濃度之方法，其包含投予如請求項1至84中任一項之化合物或其醫藥上可接受之鹽。
  93. 如請求項92之方法，其中該血液苯丙胺酸濃度係降低至小於或等於約600 µM之濃度。
  94. 如請求項93之方法，其中該血液苯丙胺酸濃度係降低至小於或等於約360 µM之濃度。
  95. 如請求項92至94中任一項之方法，其中該對象在投予該化合物前具有大於約600 µM之血液苯丙胺酸濃度。
  96. 如請求項92至94中任一項之方法，其中該對象在投予該化合物前具有大於約1200 µM之血液苯丙胺酸濃度。
TW112107402A 2022-02-28 2023-03-01 可用於穩定苯丙胺酸羥化酶突變之化合物及方法 TW202342486A (zh)

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