TW202339711A - 預防或治療心血管疾病的高穿透性的阿司匹靈和其他非類固醇抗發炎藥的前藥 - Google Patents
預防或治療心血管疾病的高穿透性的阿司匹靈和其他非類固醇抗發炎藥的前藥 Download PDFInfo
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
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- A—HUMAN NECESSITIES
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| WOPCT/CN2022/072270 | 2022-01-17 | ||
| CN2022072270 | 2022-01-17 |
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| TW202339711A true TW202339711A (zh) | 2023-10-16 |
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| TW112101788A TW202339711A (zh) | 2022-01-17 | 2023-01-16 | 預防或治療心血管疾病的高穿透性的阿司匹靈和其他非類固醇抗發炎藥的前藥 |
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| EP (1) | EP4465993A4 (enExample) |
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| CA (1) | CA3252370A1 (enExample) |
| IL (1) | IL314290A (enExample) |
| TW (1) | TW202339711A (enExample) |
| WO (1) | WO2023134732A1 (enExample) |
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| CN118373749A (zh) * | 2024-04-29 | 2024-07-23 | 四川施成收生态科技有限公司 | 一种含有2-羟基苯甲酸-2-（二乙氨基）乙酯结构的化合物制备及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH399486A (fr) * | 1962-10-02 | 1965-09-30 | Biosedra Lab | Procédé de préparation de nouvelles salicylamides |
| CA2656858C (en) * | 2006-07-09 | 2016-01-19 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of acetylsalicylic acid |
| CN101500983B (zh) * | 2006-07-26 | 2015-09-16 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性二氟尼柳及相关化合物的前药 |
| CN111012914A (zh) * | 2012-01-18 | 2020-04-17 | 苏州泰飞尔医药有限公司 | 治疗肺部疾病的高穿透力前药组合物和医药组合物 |
| CN112521305B (zh) * | 2013-03-15 | 2023-04-25 | 苏州泰飞尔医药有限公司 | 治疗帕金森疾病的新型高穿透力药物及其药物组合物 |
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- 2023-01-12 JP JP2024542395A patent/JP2025504447A/ja active Pending
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- 2023-01-12 EP EP23740073.4A patent/EP4465993A4/en active Pending
- 2023-01-16 TW TW112101788A patent/TW202339711A/zh unknown
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| JP2025504447A (ja) | 2025-02-12 |
| US20250099491A1 (en) | 2025-03-27 |
| WO2023134732A1 (en) | 2023-07-20 |
| EP4465993A4 (en) | 2026-01-07 |
| KR20250005055A (ko) | 2025-01-09 |
| WO2023134732A9 (en) | 2024-08-08 |
| EP4465993A1 (en) | 2024-11-27 |
| AU2023206720A1 (en) | 2024-08-29 |
| IL314290A (en) | 2024-09-01 |
| CN118632699A (zh) | 2024-09-10 |
| CA3252370A1 (en) | 2023-07-20 |
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