TW202337470A - 用於縮減肝臟體積之瑞美替隆 - Google Patents

用於縮減肝臟體積之瑞美替隆 Download PDF

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Publication number
TW202337470A
TW202337470A TW111136510A TW111136510A TW202337470A TW 202337470 A TW202337470 A TW 202337470A TW 111136510 A TW111136510 A TW 111136510A TW 111136510 A TW111136510 A TW 111136510A TW 202337470 A TW202337470 A TW 202337470A
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TW
Taiwan
Prior art keywords
remetron
liver
less
prodrug
individual
Prior art date
Application number
TW111136510A
Other languages
English (en)
Chinese (zh)
Inventor
苪貝卡 陶柏
Original Assignee
美商瑪德瑞高製藥公司
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Application filed by 美商瑪德瑞高製藥公司 filed Critical 美商瑪德瑞高製藥公司
Publication of TW202337470A publication Critical patent/TW202337470A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW111136510A 2021-09-27 2022-09-27 用於縮減肝臟體積之瑞美替隆 TW202337470A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163248634P 2021-09-27 2021-09-27
US63/248,634 2021-09-27

Publications (1)

Publication Number Publication Date
TW202337470A true TW202337470A (zh) 2023-10-01

Family

ID=83900064

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111136510A TW202337470A (zh) 2021-09-27 2022-09-27 用於縮減肝臟體積之瑞美替隆

Country Status (13)

Country Link
US (2) US20240408102A1 (enExample)
EP (2) EP4578499A3 (enExample)
JP (1) JP2024536126A (enExample)
KR (1) KR20240073926A (enExample)
CN (1) CN118251221A (enExample)
AR (1) AR127165A1 (enExample)
AU (1) AU2022348966A1 (enExample)
CA (1) CA3233319A1 (enExample)
CL (1) CL2024000886A1 (enExample)
IL (1) IL311670A (enExample)
MX (1) MX2024003967A (enExample)
TW (1) TW202337470A (enExample)
WO (1) WO2023049491A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024251233A1 (zh) * 2023-06-08 2024-12-12 成都微芯药业有限公司 PPAR全激动剂联合THR-β激动剂在抗代谢相关疾病中的用途
JP2026521649A (ja) * 2023-06-22 2026-06-30 マドリガル ファーマシューティカルズ インコーポレイテッド THR-βアゴニストを用いて肝障害を治療するためのバイオマーカーおよび関連する使用
KR20260000642A (ko) * 2024-06-25 2026-01-05 연세대학교 산학협력단 Usp10 억제제를 유효성분으로 포함하는, 간섬유증 또는 간섬유증 관련 질환의 예방 또는 치료용 조성물
WO2026107045A1 (en) * 2024-11-12 2026-05-21 Madrigal Pharmaceuticals, Inc. Resmetirom for use in treating cardiomyopathy and/or related heart failure and portal hypertension

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE480524T1 (de) 2005-07-21 2010-09-15 Hoffmann La Roche Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten
US8076334B2 (en) 2007-09-20 2011-12-13 Hoffmann-La Roche Inc. Prodrugs of thyroid hormone analogs
ES2795450T3 (es) 2012-09-17 2020-11-23 Madrigal Pharmaceuticals Inc Procedimiento para sintetizar análogos de hormonas tiroideas y polimorfos de los mismos
MX394463B (es) 2016-10-18 2025-03-19 Madrigal Pharmaceuticals Inc Métodos para tratar trastornos del hígado o trastornos lipídicos con un agonista de thr-beta.
TW202615431A (zh) 2018-07-02 2026-04-16 美商瑪德瑞高製藥公司 2-(3,5-二氯-4-((5-異丙基-6-側氧基-1,6-二氫噠嗪-3-基)氧)苯基)-3,5-二側氧基-2,3,4,5-四氫-1,2,4-三嗪-6-腈之固體型式
CA3111025C (en) * 2018-09-06 2023-10-31 Galmed Research And Development Ltd Combination therapy for the treatment of liver disease
EP4775207A2 (en) 2018-12-05 2026-07-15 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
CA3195960A1 (en) 2020-10-23 2022-04-28 Madrigal Pharmaceuticals, Inc. Process for the preparation of 6-(4-nitro-phenoxy)-2h-pyridazin-3-one and 6-(4-amino-phenoxy)-2h-pyridazin-3-one derivatives as intermediates of thyroid hormone analogues

Also Published As

Publication number Publication date
US20260069598A1 (en) 2026-03-12
IL311670A (en) 2024-05-01
JP2024536126A (ja) 2024-10-04
MX2024003967A (es) 2024-06-03
US12661361B2 (en) 2026-06-23
AU2022348966A1 (en) 2024-04-11
US20240408102A1 (en) 2024-12-12
CN118251221A (zh) 2024-06-25
EP4408428A1 (en) 2024-08-07
CL2024000886A1 (es) 2024-08-30
KR20240073926A (ko) 2024-05-27
WO2023049491A1 (en) 2023-03-30
AR127165A1 (es) 2023-12-27
CA3233319A1 (en) 2023-03-30
EP4578499A2 (en) 2025-07-02
EP4578499A3 (en) 2025-09-17

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