TW202328126A - Isoxazoline compounds and their use as pest control agents - Google Patents

Abstract

The present invention discloses an isoxazoline compound of formula (I), wherein, R ¹, R ³, Cy, ring-Q, A, D, p and q are as defined in the detailed description. The present invention further discloses methods for preparation of compounds of formula (I) and use of the compounds of formula (I) as a pest control agent.

Description

Isoxazoline compounds and their use as pest control agents

The present invention relates to compounds of formula (I). More specifically, the present invention relates to isoxazoline compounds of formula (I) and methods for their preparation. The present invention further relates to the use of isoxazoline compounds of formula (I) as pest control agents.

Invertebrate pests, especially arthropods and nematodes, can damage growing and harvested crops, and insects can also attack wooden residential and commercial structures, causing huge economic losses to property. Therefore, there is a continuing need for new agents useful against invertebrate pests such as insects, arachnids and nematodes. Modern insecticides and acaricides currently available have to fulfill many requirements, eg with regard to degree of activity, long-lasting efficacy, breadth of insecticidal effect and other beneficial effects and their possible uses. Efforts have been made over the past few decades to develop selective insecticides that act only on specific biochemical modes of action in insects or mites, but otherwise in a manner different from The known insecticides exhibit their properties in an advantageous manner.

Isoxazoline compounds having insecticidal activity are known and described, for example, in PCT Patent Publication No. WO2008154528, PCT Patent Publication No. WO2009022746, PCT Patent Publication No. WO2009112275, PCT Patent Publication No. WO2010020522, PCT Patent Publication No. WO2012060317 And PCT Patent Publication No. WO2020018610. These documents disclose substituted isoxazoline rings and substituted aryl or heteroaryl rings linked through carbon-carbon bonds, while the present invention discloses substituted isoxazoline rings linked through carbon-nitrogen bonds rings and substituted heterocyclyl rings.

PCT Patent Publication No. WO2022003610 discloses isoindoline-carboxamide compounds, however, N-linked hetero-bicyclic groups are not disclosed.

There is a constant need for novel compounds that are more effective against invertebrate pests, are less toxic, are safer for the environment, and/or have different modes of action.

In view of the above facts, the present invention contemplates such compounds which meet or overcome the disadvantages associated with the prior art. It has now surprisingly been found that certain novel, insecticidally active isoxazoline rings bearing the isoindoline ring compounds which are the subject of the present invention have desirable properties as insecticides .

Accordingly, the present invention provides an isoxazoline compound of formula (I), or its agriculturally acceptable salts, stereoisomers, and diastereomers , enantiomers, tautomers, metal complexes, polymorphs or N-oxides. Formula (I) wherein, R ¹ , R ³ , Cy, ring Q, A, D, p and q are as defined in the detailed description below.

In one embodiment, the present invention provides a method for preparing a compound of formula (I) or an agriculturally acceptable salt thereof.

In another embodiment, the present invention provides a composition for controlling or preventing invertebrate pests, the composition comprising an effective amount of the compound of formula (I), its agriculturally acceptable salt, stereoisomer , diastereomers, enantiomers, tautomers, metal complexes, polymorphs or N-oxides, and at least one additional compound selected from the group consisting of surfactants and auxiliary agents Element.

In yet another embodiment, the composition further comprises at least one additional bioactive compatible compound selected from fungicides, insecticides, nematocides, acaricides, biopesticides, herbicides , plant growth regulators, antibiotics, fertilizers or nutrients.

In another embodiment, the present invention provides the compound of formula (I) and its agriculturally acceptable salts, stereoisomers, diastereomers, mirror isomers, tautomers, metal complexes , polymorphs or N-oxides, compositions or combinations thereof for the control of invertebrate pests in agricultural and horticultural crops and parasites on animals or in wooden residential and commercial structures.

In yet another embodiment, the present invention provides a method of combating an invertebrate pest comprising exposing the invertebrate pest, its habitat, breeding ground, food supply, plant, seed, soil, area, material or insect and acarid to The environment in which pests are growing or may grow, or the material, plant, seed, soil, surface or space to be protected from pest attack or infestation and a biologically effective amount of a compound of formula (I) or its salt, stereoisomeric Constructs, metal complexes, polymorphs, or N-oxides, compositions or combinations thereof.

definition:

Definitions provided herein for terms used in this specification are for illustrative purposes only and do not limit the scope of the present invention disclosed in this specification in any way.

As used herein, the terms "comprises, comprising", "includes, including", "has, having", "contains, containing", "characterized by" or any other variation thereof, to cover the non-exclusive inclusion, subject to any limitations expressly stated. For example, a composition, mixture, process, or method consisting of a list of elements is not necessarily limited to those elements, but may include elements not expressly listed or other elements inherent in such composition, mixture, process, or method.

The conjunction "consisting of" (consisting of) excludes any unspecified element, step or ingredient. If present in a claim item, it will render the claim item incapable of containing material other than that stated, except as impurities with which it is normally associated. When the phrase "consisting of" appears in a sentence in the body of a claim rather than immediately following the preamble, it restricts only the elements specified in that sentence; other Components are not excluded from the overall request item.

The conjunction phrase "consisting essentially of" (consisting essentially of) is used to define a composition or method comprising materials, steps, features, ingredients or elements, except for those disclosed in the context, these additional The materials, steps, features, components or elements do not materially affect the basic and novel characteristics of the claimed invention. The phrase "consisting essentially of" occupies the middle position between "comprising" and "consisting of".

Further, unless expressly stated to the contrary, "or" means an inclusive "or" rather than an exclusive "or". For example, a condition A "or" B is satisfied by any of the following: A is true (or exists), B is false (or does not exist), A is false (or does not exist), B is true (or exists ), and both A and B are true (or exist).

Likewise, the indefinite article "a" (a and an) preceding an element or component of the invention is intended not to limit the instance (ie, the number of occurrences) of that element or component. Thus, "a" (a or an) should be read to include one or at least one, and word forms of elements or components in the singular include the plural unless it is obvious that the number is meant in the singular.

The term "invertebrate pest" as used herein includes pests such as arthropods, gastropods and nematodes of economic importance. The term "arthropod" includes insects, mites, spiders, scorpions, centipedes, millipedes, bulb bugs and myriapods. The term "gastropod" includes snails, slugs and other Stylommatophora. The term "nematode" refers to living organisms of the Phylum Nematoda. The term "helminths" includes roundworms, heartworms, Nematoda, Tematoda, acanthocephala and cestoda.

The term "agronomic" refers to the production of field crops, such as for food, feed, and fiber, and includes corn, soybeans and other legumes, rice, grains (such as wheat, oats, barley, rye, rice, corn ), leafy vegetables (such as lettuce, kale and other canola crops), fruit vegetables (such as tomato, pepper, eggplant, cruciferous and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (such as pome fruit, stone fruit and citrus), small fruits (berries, cherries) and other specialty crops (e.g. rape, sunflower, olives).

The term "nonagronomic" refers to crops other than agricultural crops, such as horticultural crops (e.g., greenhouses, nurseries, or ornamentals that are not grown in fields), residential, agricultural, commercial and industrial structures, turf (e.g., sod farms, pastures, golf courses, lawns, sports fields, etc.), wood products, stored products, agroforestry and vegetation management, public health (i.e. humans) and animal health (e.g. domesticated animals (e.g. pets, livestock and poultry) and non-domesticated animals (e.g. animals)) applications.

Non-agronomic applications include the protection of animals from invertebrates by administering to the animal to be protected a parasiticidally effective (i.e. biologically effective) amount of a compound of the invention, usually in the form of a composition formulated for veterinary use. Infestation by parasitic pests. As referred to in the specification and claims of this case, the terms "parasiticidal" and "parasiticidally" mean the observable effect on invertebrate parasitic pests of protecting animals from pest infestation . A parasiticidal effect generally involves reducing the occurrence or activity of a target invertebrate parasitic pest. Such effects on pests include necrosis, death, stunted growth, reduced mobility or ability to remain on or in the host animal, reduced feeding and inhibited reproduction. These effects on invertebrate parasitic pests provide control (including prevention, reduction or elimination) of parasitic infestation or infection in animals.

The compounds of the invention may exist purely or in different possible isomeric forms or as optical isomers, for example stereoisomers or structural isomers. Various stereoisomers include enantiomers, diastereoisomers, chiral isomers, atropisomers, conformers, rotamers ( rotamers), tautomers, optical isomers, polymorphs, and geometric isomers. Any desired mixtures of these isomers are within the scope of the claims herein. Those of ordinary skill in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other isomer or when it is isolated from the other isomer . Furthermore, processes or methods or techniques for separating, concentrating and/or selectively preparing said isomers are known to those of ordinary skill in the art.

Definitions of various terms used in the specification will now be explained.

The term "enantiomerically enriched" refers to a chiral material with an enentiomeric ratio greater than 50:50 but less than 100:0.

As used herein, the term "aliphatic compound" or "aliphatic group" refers to an organic compound whose carbon atoms are connected in a straight chain, branched chain or non-aromatic ring.

The term "alkyl", whether used alone or in compound form (such as "alkylthio" or "haloalkyl" or -N(alkyl) or alkylcarbonylalkyl or alkylsulfonamido, Including linear or branched C ₁ to C ₁₂ alkyl, preferably C ₁ to C ₈ alkyl, most preferably C ₁ to C ₆ alkyl. Non-limiting examples of alkyl include methyl, Ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethyl Propyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl , 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2- Ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methyl Propyl or different isomers. If the alkyl group is at the end of the composite substituent, such as in an alkylcycloalkyl group, the initial part of the composite substituent, such as a cycloalkyl group, may be identically or differently replaced by the alkyl group and independently monosubstituted or polysubstituted. The same applies to composite substituents in which other groups, such as alkenyl, alkynyl, hydroxyl, halogen, carbonyl, carbonyloxy, etc., are terminally located.

_The term " _cyanoalkyl " _as used herein refers to _a Alkyl group") carbon atoms (as described above), of which 1 or 2, preferably 1 hydrogen atom is replaced by a nitrile (CN) group straight or branched chain alkyl. Non-limiting examples are nitrile methyl, 1-nitrile ethyl, 2-nitrile ethyl, 1-nitrile propyl, 2-nitrile propyl, 3-nitrile propyl, 1-nitrile butyl, 2-nitrile butyl , 3-nitrile butyl, 4-nitrile butyl, etc.

The term "alkenyl", whether used alone or in compound form, includes straight or branched C ₂ -C ₁₂ alkenes, more preferably C ₂ -C ₈ alkenes, most preferably C ₂ -C ₆ olefins. Non-limiting examples of alkenes include vinyl, 1-propenyl, 2-propenyl, 1-methylvinyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl- 1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl Alkenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl Alkenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl Base-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethane Base-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl Base-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl Base, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl -3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl , 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, l,l-dimethyl-3-butenyl , 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl -1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2 ,3-Dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1 -butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butene Base, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-Ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl and 1-ethyl-2-methyl-2-propenyl and different isomers . "Alkenyl" also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. Unless specifically defined elsewhere, this definition also applies to alkenyl as part of a composite substituent, eg haloalkenyl and the like.

The term "alkynyl", whether used alone or in compound form, includes straight or branched C ₂ -C ₁₂ alkynes, more preferably C ₂ -C ₈ alkynes, most preferably C ₂ -C ₆ alkyne. Non-limiting examples of alkynes include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl Alkynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2 -Methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 1-hexyne Base, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1- Methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl Alkynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, l,l-dimethyl-3-butane Alkynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl- 2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl and the different isomers. This definition also applies to alkynyl as part of a composite substituent, eg haloalkynyl, etc., unless specifically defined elsewhere. The term "alkynyl" may also include moieties consisting of multiple triple bonds, eg 2,5-hexadiynyl.

The term "cycloalkyl" refers to an alkyl group that is closed to form a ring. Non-limiting examples include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. This definition also applies to cycloalkyl groups as part of a composite substituent, eg cycloalkylalkyl etc., unless specifically defined elsewhere.

The term "cycloalkenyl" refers to an alkenyl group that is closed to form a ring including a monocyclic, partially unsaturated hydrocarbon group. Non-limiting examples include cyclopropenyl, cyclopentenyl, and cyclohexenyl. This definition also applies to cycloalkenyl as part of a composite substituent, eg cycloalkenylalkyl, etc., unless specifically defined elsewhere.

The term "cycloalkynyl" refers to an alkynyl group that is closed to form a ring including a monocyclic, partially unsaturated group. Non-limiting examples include cyclopropynyl, cyclopentynyl, and cyclohexynyl. This definition also applies to cycloalkenyl as part of a composite substituent, eg cycloalkynylalkyl, etc., unless specifically defined elsewhere.

The terms "cycloalkoxy", "cycloalkenyloxy" and the like are defined similarly. Non-limiting examples of cycloalkoxy include cyclopropoxy, cyclopentyloxy, and cyclohexyloxy. This definition also applies to cycloalkoxy as part of a composite substituent, eg cycloalkoxyalkyl, etc., unless specifically defined elsewhere.

As used herein, the term "cyanocycloalkyl" refers to a group that is closed to form a compound having 3 to 8 ("C ₃ -C ₈ -cyanoalkyl") or 1 to 4 ("C ₁ -C ₄ - cyanoalkyl") carbon atoms (as previously described), wherein 1 or 2 hydrogens in these groups, preferably 1 hydrogen atom is replaced by a nitrile (CN) group straight or branched Alkanes. Non-limiting examples are 1-cyanocyclopropyl, 2-cyanocyclopropyl, 1-cyanocyclobutyl, 2-cyanocyclobutyl, 3-cyanocyclobutyl, 1-cyanocyclobutyl, Pentyl, 2-cyanocyclopentyl, 3-cyclopentyl, 4-cyclopentyl, 1-cyanohexyl, 2-cyanohexyl, 3-cyanocyclohexyl, 4-cyanocyclohexyl and the like.

The term "alkoxy", whether used alone or as a compound, includes C ₁ to C ₁₂ alkoxy, preferably C ₁ to C ₈ alkoxy, most preferably C ₁ to C ₆ alkoxy. Examples of alkoxy groups include methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1- Dimethylethoxy, pentyloxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethyl Propoxy, Hexyloxy, 1,1-Dimethylpropoxy, 1,2-Dimethylpropoxy, 1-Methylpentyloxy, 2-Methylpentyloxy, 3-Methyl Pentyloxy, 4-methylpentyloxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2-methoxy, Ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentyloxy , 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexyloxy, 1, 1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentyloxy, 2-methylpentyloxy, 3-methylpentyloxy, 4-methylpentyloxy base, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3- Dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2 , 2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy and different isomers. Unless specifically defined elsewhere, this definition also applies to alkoxy as part of a composite substituent, eg haloalkoxy, alkynylalkoxy, and the like.

The term "alkoxyalkyl" denotes an alkoxy substitution on an alkyl group. _Non -limiting _{examples of " alkoxyalkyl " include CH3OCH2 , CH3OCH2CH2 , CH3CH2OCH2 , CH3CH2CH2CH2OCH2 ,} and _{CH3CH2OCH2CH 2} .

As used herein, the term "alkylthio" (or alkylsulfanyl (-S-alkyl)) refers to a straight or branched saturated alkyl group having 1 to 10 carbon atoms, preferably linked through a sulfur atom. 1 to 6 carbon atoms. The term "alkylthio" includes branched or straight chain alkylthio moieties such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2 -Dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3- Dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2- Ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio and 1-ethyl- Different isomers such as 2-methylpropylthio.

As used herein, the term "alkylsulfinyl" (alkylsulfinyl or alkylsulfoxyl (-S(=O)-alkyl)) refers to a straight-chain or branched saturated alkyl group having 1 to 10 carbon atoms (as described above said), preferably 1 to 6 carbon atoms (C ₁ -C ₆ -alkylsulfinyl), more preferably 1 to 3 carbon atoms bonded to the alkyl through the sulfur atom of the sulfinyl group any position of the base. Non-limiting examples of "alkylsulfinyl" include, but are not limited to, methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butane Sulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylsulfinyl, pentylsulfinyl, 1-methylsulfinyl Butyl butylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, propyldimethylsulfinyl, hexylsulfinyl, 1,1- Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 1-methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methyl Pentylsulfinyl, 4-methylpentylsulfinyl, 1,1-dimethylbutylsulfinyl, 1,2-dimethylbutylsulfinyl, 1,3- Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3-Dimethylbutylsulfinyl 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1,1,2-trimethylpropylsulfinyl, 1,2,2-trimethylpropyl Sulfinyl, 1-ethyl-1-methylpropylsulfinyl and 1-ethyl-2-methylpropylsulfinyl and different isomers. The term "arylsulfinyl" includes Ar-S(O), wherein Ar can be any carbocyclic or heterocyclic ring. Unless specifically defined elsewhere, this definition also applies to alkylsulfinyl groups as part of a composite substituent, eg haloalkylsulfinyl and the like.

As used herein, the term "alkylsulfonyl" (alkylsulfonyl) (-S(=O) ₂ -alkyl) refers to a linear or branched saturated alkyl group having 1 to 10 carbon atoms, preferably 1 to 6 carbon atoms (C ₁ -C ₆ -alkylsulfinyl), more preferably 1 to 3 carbon atoms are connected to any position of the alkyl group through the sulfur atom of the sulfonyl group. Non-limiting examples of "alkylsulfonyl" include, but are not limited to, methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2- Methylbutylsulfonyl, 3-methylbutylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylsulfonyl, hexylsulfonyl, 1,1-dimethyl Propylsulfonyl, 1,2-dimethylpropylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2 , 2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2- Ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl Acyl and 1-ethyl-2-methylpropylsulfonyl and different isomers. The term "arylsulfonyl" includes Ar-S(O) ₂ , wherein Ar can be any carbocyclic or heterocyclic ring. Unless specifically defined elsewhere, this definition also applies to alkylsulfonyl groups as part of a composite substituent, eg alkylsulfonylalkyl and the like.

The term "alkylthioalkyl" denotes an alkylthio substitution on an alkyl group. Representative examples of "alkylthioalkyl" include -CH ₂ SCH ₂ , -CH ₂ SCH ₂ CH ₂ , CH ₃ CH ₂ SCH ₂ , CH ₃ CH ₂ CH ₂ CH ₂ SCH ₂ , and CH ₃ CH ₂ SCH _{2 CH2} . "Alkylthioalkoxy" means an alkylthio substitution on an alkoxy group. The term "cycloalkylalkylamino" denotes cycloalkyl substitution on an alkylamine group.

The terms "alkoxyalkoxyalkyl", "alkylaminoalkyl", "dialkylaminoalkyl", "cycloalkylaminoalkyl" ( cycloalkylaminoalkyl), "cycloalkylaminocarbonyl" (cycloalkylaminocarbonyl), etc. are defined similarly to "alkylthioalkyl" or "cycloalkylalkylamino".

The term "halogen", whether used alone or in compound form (eg "haloalkyl"), includes fluorine, chlorine, bromine or iodine. In addition, when used in compound words such as "haloalkyl", said alkyl group may be partially or completely substituted by halogen atoms, and the halogen atoms may be the same or different. Non-limiting examples of "haloalkyl" include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichloro Fluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-tri Fluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl , pentafluoroethyl, 1,1-dichloro-2,2,2-trifluoroethyl and 1,1,1-trifluoropropyl-2-yl. Unless specifically defined elsewhere, this definition also applies to haloalkyl as part of a composite substituent, eg haloalkylaminoalkyl and the like.

The terms "haloalkenyl" and "haloalkynyl" are similarly defined except that alkenyl and alkynyl groups are present as part of a substituent instead of an alkyl group.

The term "haloalkoxy" refers to straight-chain or branched-chain alkoxy groups, wherein some or all of the hydrogen atoms in these groups may be replaced by the above-mentioned halogen atoms. Non-limiting examples of haloalkoxy include chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chloro Fluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1-bromoethoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2 -Difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro -2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy and l,l,l-trifluoroprop-2-oxyl. Unless specifically defined elsewhere, this definition also applies to haloalkoxy as part of a composite substituent, eg haloalkoxyalkyl and the like.

The term "haloalkylthio" refers to a straight-chain or branched alkylthio group in which some or all of the hydrogen atoms in these groups may be replaced by the above-mentioned halogen atoms. Non-limiting examples of haloalkylthio include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chloro Fluoromethylthio, dichlorofluoromethylthio, chlorodifluoromethylthio, 1-chloroethylthio, 1-bromoethylthio, 1-fluoroethylthio, 2-fluoroethylthio, 2,2 -Difluoroethylthio, 2,2,2-trifluoroethylthio, 2-chloro-2-fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2-dichloro -2-fluoroethylthio, 2,2,2-trichloroethylthio, pentafluoroethylthio and 1,1,1-trifluoroprop-2-ylthio. Unless specifically defined elsewhere, this definition also applies to haloalkylthio as part of a composite substituent, eg haloalkylthioalkyl and the like.

Non-limiting examples of "haloalkylsulfinyl" include CF ₃ S(O), CCl ₃ S(O), CF ₃ CH ₂ S(O), and CF ₃ CF ₂ S(O). Non-limiting examples of "haloalkylsulfonyl" include CF ₃ S(O) ₂ , CCl ₃ S(O) ₂ , CF ₃ CH ₂ S(O) ₂ , and CF ₃ CF ₂ S(O) ₂ .

Halocycloalkyl, Halocycloalkenyl, Alkylcycloalkyl, Cycloalkylalkyl, Cycloalkoxyalkyl, Alkylsulfinylalkyl, Alkylsulfonylalkyl, Haloalkylcarbonyl , cycloalkylcarbonyl, haloalkoxyalkyl, etc. are defined similarly to the above examples.

The term "hydroxy" refers to -OH, and amine refers to -NRR, where R can be H or any possible substituent, such as alkyl. Carbonyl means -C(O)-, carbonyloxy means -OC(O)-, sulfinyl means SO, and sulfonyl means S(O) ₂ .

The term "alkylcarbonyl" refers to an alkyl group bonded to the main chain through a carbonyl group (-CO-). Unless specifically defined elsewhere, this definition also applies to alkylcarbonyl as part of a composite substituent, eg cycloalkylalkylcarbonyl and the like.

The term "alkoxycarbonyl" refers to an alkoxy group bonded to the main chain through a carbonyl group (-CO-). Unless specifically defined elsewhere, this definition also applies to alkoxycarbonyl as part of a composite substituent, eg cycloalkylalkoxycarbonyl and the like.

The term "alkoxycarbonylalkylamino" denotes an alkoxycarbonyl substitution on an alkylamine group. "Alkylcarbonylalkylamino" means an alkylcarbonyl substitution on an alkylamino group. The terms "alkylthioalkoxycarbonyl", "cycloalkylalkylaminoalkyl", etc. are defined similarly.

Non-limiting examples of "alkylcarbonyl" include C(O) _CH3 , C(O) _{CH2CH2CH3 ,} and C( _O )CH( _CH3 ) ₂ . Non-limiting examples of "alkoxycarbonyl" include CH ₃ OC(=O), CH ₃ CH ₂ OC(=O), CH ₃ CH ₂ CH ₂ OC(=O), (CH ₃ ) ₂ CHOC(= O) and the different butoxy- or pentyloxycarbonyl isomers. Non-limiting examples of "alkylaminocarbonyl" include CH ₃ NHC(=O), CH ₃ CH ₂ NHC(=O), CH ₃ CH ₂ CH ₂ NHC(=O), (CH ₃ ) ₂ CHNHC( =O) and the different butylamino- or pentylaminocarbonyl isomers. Non-limiting examples of "dialkylaminocarbonyl" include (CH ₃ ) ₂ NC(=0), (CH ₃ CH ₂ ) ₂ NC(=0), CH ₃ CH ₂ (CH ₃ )NC(=0 ), CH ₃ CH ₂ CH ₂ (CH ₃ )NC(=O), and (CH ₃ ) ₂ CHN(CH ₃ )C(=O). Non-limiting examples of "alkoxyalkylcarbonyl" include CH ₃ OCH ₂ C(=O), CH ₃ OCH ₂ CH 2 C(=O), CH ₃ CH _{2 OCH 2 C} (=O), CH _{3 CH2CH2CH2OCH2C} ( ₌ 0) _{and CH3CH2OCH2CH2C (} = _{0 ) .} Non-limiting examples of "alkylthioalkylcarbonyl" include CH ₃ SCH ₂ C(=0), CH ₃ SCH ₂ CH ₂ C(=0), CH ₃ CH ₂ SCH ₂ C(=0), CH _{3 CH2CH2CH2SCH2C ( =} 0) and _{CH3CH2SCH2CH2C ( =} 0 _{) .} The terms "haloalkylsulfonylaminocarbonyl", "alkylsulfonylaminocarbonyl", "alkylthioalkoxycarbonyl", "alkoxycarbonylalkylamino" and the like are similarly defined . Non-limiting examples of "alkylaminoalkylcarbonyl" include CH ₃ NHCH ₂ C(=0 ₎ , CH ₃ NHCH ₂ CH ₂ C(=0), CH ₃ CH 2 NHCH ₂ C(=0), CH ₃ CH ₂ CH ₂ CH ₂ NHCH ₂ C(=0) and CH ₃ CH ₂ NHCH ₂ CH ₂ C(=0).

"Alkylamino", "dialkylamino" and the like are defined similarly to the above examples.

The term "hetero" in relation to rings refers to a ring having at least one ring atom other than carbon and which may contain 1 to 4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, assuming each ring Contains not more than four nitrogens, not more than two oxygens and not more than two sulfurs.

The term "aromatic" means that the Huckel rule is satisfied, and the term "non-aromatic" means that the Huckel rule is not satisfied.

The term "heterocycle" (heterocyclic or heterocyclic ring system) includes "aromatic heterocycle or heteroaryl bicycle ring system" and "nonaromatic heterocycle ring system" or Polycyclic or bicyclic (spiro, fused, bridged, non-fused) ring compounds, wherein the rings may be aromatic or non-aromatic, wherein the heterocyclic ring contains at least one member selected from N, O, S(O) _0-2 Heteroatoms, and/or carbon ring members of heterocycles may be substituted by C(=O), C(=S), C(=CR*R*) and C=NR*, and * represents an integer.

The term "non-aromatic heterocycle" (non-aromatic heterocycle or non-aromatic heterocyclic) refers to three to fifteen membered (preferably three to ten) members containing 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur Two-membered) saturated or partially unsaturated heterocycles: mono-, bi- or tricyclic heterocycles which, in addition to carbon ring members, contain one to three nitrogen atoms and/or one oxygen or sulfur atom or one or two oxygen atoms and/or sulfur atoms; if the ring contains more than one oxygen atom, they are not directly adjacent; non-limiting examples: oxiranyl, oxetanyl, aziridinyl (aziridinyl), azetidinyl (azetidinyl), thietanyl (thietanyl), 1-oxide thietanyl 1-oxide, 1,1-dioxide thietanyl (thietanyl 1,1-dioxide), 2-tetrahydrofuranyl (2-tetrahydrofuranyl), 3-tetrahydrofuranyl (3-tetrahydrofuranyl), 2-tetrahydrothienyl (2-tetrahydrothienyl), 3-tetrahydrofuranyl (3- tetrahydrothienyl), 1-pyrrolidinyl (1-pyrrolidinyl), 2-pyrrolidinyl (2-pyrrolidinyl), 3-pyrrolidinyl (3-pyrrolidinyl), 3-isoxazolidinyl (3-isoxazolidinyl), 4 -isoxazolidinyl (4-isoxazolidinyl), 5-isoxazolidinyl (5-isoxazolidinyl), 3-isothiazolidinyl (3-isothiazolidinyl), 4-isothiazolidinyl (4-isothiazolidinyl), 5 -isothiazolidinyl (5-isothiazolidinyl), 1-pyrazolidinyl (1-pyrazolidinyl), 3-pyrazolidinyl (3-pyrazolidinyl), 4-pyrazolidinyl (4-pyrazolidinyl), 5-pyridine 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl (2-thiazolidinyl), 4-thiazolidinyl (4-thiazolidinyl), 5-thiazolidinyl (5-thiazolidinyl), 1-imidazolidinyl (1-imidazolidinyl), 2-imidazolidinyl (2-imidazolidinyl), 4-imidazolidinyl (4-imidazolidinyl), 1,2,4-oxadiazolidin-3-yl (1,2,4-oxadiazolidin-3-yl), 1,2,4-oxadiazolidinyl Base-5-yl (1,2,4-oxadiazolidin-5-yl), 1,2,4-thiadiazolidin-3-yl (l,2,4-thiadiazolidin-3-yl), 1,2 ,4-Thiadiazolidin-5-yl (1,2,4-thiadiazolidin-5-yl), 1,2,4-triazolidin-1-yl (1,2,4-triazolidin-1-yl ), l,2,4-triazolidin-3-yl (l,2,4-triazolidin-3-yl), 1,3,4-oxadiazolin-2-yl (1,3,4- oxadiazolidin-2-yl), 1,3,4-thiadiazolidin-2-yl (1,3,4-thiadiazolidin-2-yl), 1,3,4-triazolidin-1-yl (1 ,3,4-triazolidin-1-yl), 1,3,4-triazolidin-2-yl (1,3,4-triazolidin-2-yl), 2,3-dihydrofuran-2-yl (2,3-dihydrofur-2-yl), 2,3-dihydrofuran-3-yl (2,3-dihydrofur-3-yl), 2,4-dihydrofuran-2-yl (2,4 -dihydrofur-2-yl), 2,4-dihydrofur-3-yl (2,4-dihydrofur-3-yl), 2,3-dihydrothiophen-2-yl (2,3-dihydrothien-2 -yl), 2,3-dihydrothiophen-3-yl (2,3-dihydrothien-3-yl), 2,4-dihydrothiophen-2-yl (2,4-dihydrothien-2-yl), 2,4-Dihydrothien-3-yl (2,4-dihydrothien-3-yl), pyrrolinyl (pyrrolinyl), 2-pyrrolin-2-yl (2-pyrrolin-2-yl), 2- Pyrrolin-3-yl (2-pyrrolin-3-yl), 3-pyrrolin-2-yl (3-pyrrolin-2-yl), 3-pyrrolin-3-yl (3-pyrrolin-3-yl ), 2-isoxazolin-3-yl (2-isoxazolin-3-yl), 3-isoxazolin-3-yl (3-isoxazolin-3-yl), 4-isoxazolin-3 -yl (4-isoxazolin-3-yl), 2-isoxazolin-4-yl (2-isoxazolin-4-yl), 3-isoxazolin-4-yl (3-isoxazolin-4-yl ), 4-isoxazolin-4-yl (4-isoxazolin-4-yl), 2-isoxazolin-5-yl (2-isoxazolin-5-yl), 3-isoxazolin-5 -yl (3-isoxazolin-5-yl), 4-isoxazolin-5-yl (4-isoxazolin-5-yl), 2-isothiazolin-3-yl (2-isothiazolin-3-yl) , 3-isothiazolin-3-yl (3-isothiazolin-3-yl), 4-isothiazolin-3-yl (4-isothiazolin-3-yl), 2-isothiazolin-4-yl (2 -isothiazolin-4-yl), 3-isothiazolin-4-yl (3-isothiazolin-4-yl), 4-isothiazolin-4-yl (4-isothiazolin-4-yl), 2-isothiazolin Lin-5-yl (2-isothiazolin-5-yl), 3-isothiazolin-5-yl (3-isothiazolin-5-yl), 4-isothiazolin-5-yl (4-isothiazolin-5- yl), 2,3-dihydropyrazol-1-yl (2,3-dihydropyrazol-1-yl), 2,3-dihydropyrazol-2-yl (2,3-dihydropyrazol-2-yl) , 2,3-dihydropyrazol-3-yl (2,3-dihydropyrazol-3-yl), 2,3-dihydropyrazol-4-yl (2,3-dihydropyrazol-4-yl), 2 ,3-dihydropyrazol-5-yl (2,3-dihydropyrazol-5-yl), 3,4-dihydropyrazol-1-yl (3,4-dihydropyrazol-1-yl), 3,4 -Dihydropyrazol-3-yl (3,4-dihydropyrazol-3-yl), 3,4-dihydropyrazol-4-yl (3,4-dihydropyrazol-4-yl), 3,4-dihydropyrazol-4-yl Hydropyrazole-5-yl (3,4-dihydropyrazol-5-yl), 4,5-dihydropyrazol-1-yl (4,5-dihydropyrazol-l-yl), 4,5-dihydropyrazole Azol-3-yl (4,5-dihydropyrazol-3-yl), 4,5-dihydropyrazol-4-yl (4,5-dihydropyrazol-4-yl), 4,5-dihydropyrazol-4-yl 5-yl (4,5-dihydropyrazol-5-yl), 2,3-dihydrooxazol-2-yl (2,3-dihydrooxazol-2-yl), 2,3-dihydrooxazol-3-yl (2,3-dihydrooxazol-3-yl), 2,3-dihydrooxazol-4-yl (2,3-dihydrooxazol-4-yl), 2,3-dihydrooxazol-5-yl ( 2,3-dihydrooxazol-5-yl), 3,4-dihydrooxazol-2-yl (3,4-dihydrooxazol-2-yl), 3,4-dihydrooxazol-3-yl (3, 4-dihydrooxazol-3-yl), 3,4-dihydrooxazol-4-yl (3,4-dihydrooxazol-4-yl), 3,4-dihydrooxazol-5-yl (3,4- dihydrooxazol-5-yl), 3,4-dihydrooxazol-2-yl (3,4-dihydrooxazol-2-yl), 3,4-dihydrooxazol-3-yl (3,4-dihydrooxazol- 3-yl), 3,4-dihydrooxazol-4-yl (3,4-dihydrooxazol-4-yl), piperidinyl (piperidinyl), 2-piperidinyl (2-piperidinyl), 3-piperidinyl 3-piperidinyl, 4-piperidinyl, pyrazinyl, morpholinyl, thiomorphlinyl, 1,3-dioxane-5 -yl (1,3-dioxan-5-yl), 2-tetrahydropyranyl (2-tetrahydropyranyl), 4-tetrahydropyranyl (4-tetrahydropyranyl), 2-tetrahydrothienyl (2-tetrahydrothienyl ), 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4-hexahydropyrimidinyl ), 5-hexahydropyrimidinyl (5-hexahydropyrimidinyl), 2-piperazinyl (2-piperazinyl) and cycloserines (cycloserines). Unless specifically defined elsewhere, this definition also applies to heterocyclyl as part of a composite substituent, eg heterocyclylalkyl and the like.

The term "heteroaryl" or "aromatic heterocycle" means a five- or six-membered, fully unsaturated monocyclic ring system containing 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur; if the ring contains more than one oxygen atoms, if they are not directly adjacent; five-membered heteroaryl groups containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom; five-membered heteroaryl groups, which may contain, in addition to carbon atoms, One to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom as ring members, such as (but not limited to): furyl (furyl), thienyl (thienyl), pyrrolyl (pyrrolyl), isoxazole isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, 1,2,4-oxadiazolyl (1 ,2,4-oxadiazolyl), 1,2,4-thiadiazolyl (1,2,4-thiadiazolyl), 1,2,4-triazolyl (1,2,4-triazolyl), 1,3 ,4-oxadiazolyl (1,3,4-oxadiazolyl), 1,3,4-thiadiazolyl (1,3,4-thiadiazolyl), 1,3,4-triazolyl (1,3 ,4-triazolyl), tetrazolyl; nitrogen-bonded five-membered heteroaryl containing one to four nitrogen atoms, or benzo-fused nitrogen-bonded five-membered heteroaryl containing one to three nitrogen atoms: Five-membered heteroaryl, which may contain, in addition to carbon atoms, one to four nitrogen atoms or one to three nitrogen atoms as ring members, of which two adjacent carbon ring members or one nitrogen and one adjacent carbon ring Members can be bridged by a group of but-1,3-diene-1,4-diyl, one or two carbon atoms can be replaced by nitrogen atoms, where these rings are connected to the main chain through one of the nitrogen ring members Above, non-limiting examples: 1-pyrrolyl (1-pyrrolyl), 1-pyrazolyl (1-pyrazolyl), 1,2,4-triazol-1-yl (1,2,4-triazol-1 -yl), 1-imidazolyl (1-imidazolyl), 1,2,3-triazol-1-yl (1,2,3-triazol-1-yl) and 1,3,4-triazole-1 -yl (1,3,4-triazol-1-yl).

Six-membered heteroaryl group containing one to four nitrogen atoms: In addition to carbon atoms, six-membered heteroaryl group containing one to three and one to four nitrogen atoms as ring members, such as (but not limited to): 2-pyridinyl (2-pyridinyl), 3-pyridinyl (3-pyridinyl), 4-pyridinyl (4-pyridinyl), 3-pyridazinyl (3-pyridazinyl), 4-pyridazinyl (4-pyridazinyl ), 2-pyrimidinyl (2-pyrimidinyl), 4-pyrimidinyl (4-pyrimidinyl), 5-pyrimidinyl (5-pyrimidinyl), 2-pyrazinyl (2-pyrazinyl), 1,3,5-tri Azin-2-yl (1,3,5-triazin-2-yl), 1,2,4-triazin-3-yl (1,2,4-triazin-3-yl) and 1,2,4 ,5-tetrazin-3-yl (1,2,4,5-tetrazin-3-yl); benzo-fused five-membered heteroaryl containing one to three nitrogen atoms or one nitrogen atom and one oxygen or sulfur atom Groups such as (but not limited to): indol-1-yl (indol-l-yl), indol-2-yl (indol-2-yl), indol-3-yl (indol-3-yl) , indol-4-yl (indol-4-yl), indol-5-yl (indol-5-yl), indol-6-yl (indol-6-yl), indol-7-yl ( indol-7-yl), benzimidazol-1-yl, benzimidazol-2-yl, benzimidazol-4-yl ), benzimidazol-5-yl, indazol-1-yl, indazol-3-yl, indazol-4- Indazol-4-yl, indazol-5-yl, indazol-6-yl, indazol-7-yl , Indazol-2-yl (indazol-2-yl), 1-benzofuran-2-yl (1-benzofuran-2-yl), l-benzofuran-3-yl (1-benzofuran-3- yl), 1-benzofuran-4-yl (1-benzofuran-4-yl), 1-benzofuran-5-yl (1-benzofuran-5-yl), 1-benzofuran-6-yl (1-benzofuran-6-yl), 1-benzofuran-7-yl (1-benzofuran-7-yl), 1-benzothiophen-2-yl (1-benzothiophen-2-yl), l- Benzothiophen-3-yl (1-benzothiophen-3-yl), l-benzothiophen-4-yl (l-benzothiophen-4-yl), 1-benzothiophen-5-yl (1-benzothiophen- 5-yl), l-benzothiophen-6-yl (1-benzothiophen-6-yl), l-benzothiophen-7-yl (1-benzothiophen-7-yl), 1,3-benzothiazole -2-yl (1,3-benzothiazol-2-yl), 1,3-benzothiazol-4-yl (1,3-benzothiazol-4-yl), 1,3-benzothiazol-5-yl (1,3-benzothiazol-5-yl), 1,3-benzothiazol-6-yl (1,3-benzothiazol-6-yl), 1,3-benzothiazol-7-yl (1,3 -benzothiazol-7-yl), 1,3-benzoxazol-2-yl (1,3-benzoxazol-2-yl), 1,3-benzoxazol-4-yl (1,3-benzoxazol -4-yl), 1,3-benzoxazol-5-yl (1,3-benzoxazol-5-yl), 1,3-benzoxazol-6-yl (1,3-benzoxazol-6 -yl) and 1,3-benzoxazol-7-yl (1,3-benzoxazol-7-yl); benzo-fused six-membered heteroaryl containing one to three nitrogen atoms, such as (but not limited to ): quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl (quinolin-5-yl), quinolin-6-yl (quinolin-6-yl), quinolin-7-yl (quinolin-7-yl), quinolin-8-yl (quinolin-8-yl), Isoquinolin-1-yl (isoquinolin-1-yl), isoquinolin-3-yl (isoquinolin-3-yl), isoquinolin-4-yl (isoquinolin-4-yl), isoquinolin-5 -yl (isoquinolin-5-yl), isoquinolin-6-yl (isoquinolin-6-yl), isoquinolin-7-yl (isoquinolin-7-yl) and isoquinolin-8-yl (isoquinolin- 8-yl). Unless specifically defined elsewhere, this definition also applies to heteroaryl as part of a composite substituent, eg heteroarylalkyl etc.

The term "trialkylsilyl" includes three branched and/or straight-chain alkyl groups attached to and through a silicon atom, such as trimethylsilyl, triethylsilyl, and t-butyl Base-dimethylsilyl. "Halotrialkylsilyl" means that at least one of the three alkyl groups is partially or completely substituted by the same or different halogen atoms. The term "alkoxytrialkylsilyl" means that at least one of the three alkyl groups is substituted by one or more alkoxy groups which may be the same or different. The term "trialkylsilyloxy" denotes a trialkylsilyl moiety linked through an oxygen.

The term "amide" refers to A-R'C=ONR''-B, wherein R' and R'' represent substituents, and A and B represent any groups.

The term "sulfamide" refers to A-R'C=SNR''-B, wherein R' and R'' represent substituents, and A and B represent any groups.

The total number of carbon atoms in a substituent is indicated by the prefix "C _i -C _j ", where i and j are numbers from 1 to 21. For example, C ₁ -C ₃ alkylsulfonyl means methylsulfonyl to propanesulfonyl; C ₂ alkoxyalkyl means CH ₃ OCH ₂ ; C ₃ alkoxyalkyl means for example CH ₃ CH(OCH ₃ ), CH ₃ OCH ₂ CH ₂ or CH ₃ CH ₂ OCH ₂ ; and C ₄ alkoxyalkyl means various isomers of an alkyl group substituted with an alkoxy group containing 4 carbon atoms in total, and examples include _{CH3CH2CH2OCH2 and CH3CH2OCH2CH2 . _ _ _ _} In the above description, when the compound of formula (I) consists of one or more heterocyclic rings, all substituents are attached to these rings through any available carbon or nitrogen by replacing hydrogen on said carbon or nitrogen.

When a compound is substituted by a substituent with a subscript indicating that the number of said substituents may exceed 1, said substituents (when they exceed 1) are independently selected from the defined substituents of the group. In addition, when the subscript m in (R) _m represents an integer ranging from, for example, 0 to 4, then the number of substituents may be selected from an integer ranging from 0 to 4, inclusive.

When a group contains a substituent which may be hydrogen, the group is considered unsubstituted when the substituent is considered hydrogen.

The embodiments herein and their various features and advantageous details are explained with reference to the non-limiting examples in the description. Descriptions of well-known components and processing techniques are omitted so as not to unnecessarily obscure the embodiments herein. The examples used herein are intended only to facilitate understanding of ways in which the embodiments herein may be practiced and to further enable those of ordinary skill in the art to practice the embodiments herein. Therefore, these examples should not be construed as limiting the scope of the embodiments herein.

The description of specific embodiments will fully reveal the general nature of the embodiments here, and others can easily modify and/or adapt them to specific embodiments for various applications by applying existing knowledge without departing from the general concept Therefore, such adaptations and modifications should and are intended to be understood within the meaning and range of equivalence of the disclosed embodiments. It is to be understood that the phraseology or terms used herein are for the purpose of description rather than limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those of ordinary skill in the art will recognize that the embodiments herein can be modified within the spirit and scope of the embodiments described implement.

Any discussion of documents, acts, materials, devices, objects, etc. in the specification is intended only to provide a background to the case. It should not be taken as an acknowledgment that any or all of these matters formed part of the prior art base or were common knowledge in the field relevant to this case as it existed anywhere before the priority date of this case.

Although the numerical values mentioned in the description and description/claims may constitute a key part of the present invention, any deviation from these numerical values shall still fall within the scope of the present invention if the deviation follows the same scientific principles as disclosed in the present invention. The compounds according to the invention may, if appropriate, exist as mixtures of the different possible isomeric forms, especially stereoisomers, for example E and Z, threo and erythro, and also optical isomers. But there are also tautomers if appropriate. Any desired mixtures of E and Z isomers, threo and erythro isomers and optical isomers and possible tautomeric forms are disclosed and claimed.

The term "pest" for the purposes herein includes, but is not limited to, fungi, stramenopiles (oomycetes), bacteria, nematodes, mites, ticks, insects and rodents. In addition, pests are animals that are harmful to humans or associated with humans (including crops, livestock and forestry).

The term "plants" is understood here to mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants may be plants obtainable by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including transgenic plants, and include plant breeders' rights protected and unprotected plant cultivation Variety.

For the purposes of the present invention, the term "plant" includes living organisms of the species exemplified by trees, shrubs, herbs, grasses, ferns and mosses, which normally grow in one place and absorb water and It needs substances and synthesizes nutrients in its leaves through photosynthesis.

Examples of "plants" for the purposes of the present invention include, but are not limited to, agricultural crops (such as wheat, rye, barley, triticale, oats or rice); sugar beets (such as sugar beet or fodder beet); fruits and fruit trees (such as pear fruit, drupe, or soft fruit (such as apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries); leguminous plants (such as lentils, peas, alfalfa or soybeans); oil plants (such as canola, mustard, olive, sunflower, coconut, cocoa beans, castor oil plants, oil palm, peanuts, or soybeans); cucurbits (such as squash, cucumber, or melon); fiber plants (such as cotton, flax, hemp, or jute) ; citrus fruits and citrus trees (such as oranges, lemons, grapefruits, or oranges); any garden plant; vegetables (such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, cucurbits, or peppers); laurel plants (such as avocado, cinnamon, or camphor); cucurbits; oleaginous plants; energy and raw material plants (such as cereals, corn, soybeans, other legumes, canola, sugar cane, or oil palm); tobacco; nuts; coffee ; tea; cocoa; bananas; pepper; vines (both table and brewing); hops; turf; sweet leaves (also known as Stevia); natural rubber plants or ornamental and forestry plants (e.g. Flowers, shrubs, broad-leaved or evergreen plants (such as conifers); and plant propagation material (such as seeds) and crop material of these plants.

Preferably, plants for the purposes of the present invention include, but are not limited to, cereals, corn, rice, soybeans and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any garden plant, Cucurbitaceae , oil-producing plants, tobacco, coffee, tea, cocoa, sugar beets, sugar cane, cotton, potatoes, tomatoes, onions, peppers and vegetables, ornamental plants, any flowering plants and other plants intended for human and animal use.

The term "plant parts" is understood to mean all parts and organs of above- and below-ground plants. For the purposes of the present invention, the term "plant part" includes, but is not limited to, cuttings, leaves, shoots, tubers, flowers, seeds, branches, roots (including taproots, lateral roots, root hairs, root tips, root caps, rhizomes ), branches, shoots, fruit, fruit bodies, bark, stem, buds, auxiliary buds, meristems, nodes and internodes.

The term "locus thereof" includes soil, surroundings of plants or plant parts and equipment or implements used before, during or after sowing/planting plants or plant parts.

The compound(s) of the present invention are applied to plants or plant material or their locus in compositions optionally containing other compatible compounds, including by techniques known to those of ordinary skill in the art, including but not Limited to spraying, coating, dipping, fumigating, impregnating, injecting and dusting.

The term "applied" means attached to a plant or plant part by physical or chemical (including dipping) means.

In one embodiment, the present invention provides a compound of formula (I), Formula (I) wherein, R ¹ is selected from the group consisting of: C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl and C ₃ - C ₆ -halocycloalkyl; Cy is selected from the group consisting of phenyl and C ₅ -C ₆ -heterocyclyl, which may be optionally substituted by one or more R ² groups; wherein , R ² is selected from the group consisting of hydrogen, halogen, nitrile, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ - C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl and C ₃ -C ₈ -cycloalkyl; ring Q represents a C ₅ -C ₆ -heterocyclyl, which can optionally be replaced by one or more Each R ³ group is substituted; R ³ is selected from the group consisting of hydrogen, halogen, nitrile, nitro, C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkenyl, C ₂ - C ₆ -alkynyl, C ₁ -C ₄ -haloalkyl, C ₂ -C ₄ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, C ₃ -C ₄ -cycloalkyl, C ₃ -C ₅ -heterocyclyl, -OC ₃ -C ₄ -heterocyclyl, SCN, SF ₅ , NR'R'', OR', S(O) _n R' and CR'=NR''; A is selected from The group consisting of: -CR ^a R ^b -and -C(=W)-; W represents O, S or NR ⁹ ; R ⁹ is selected from the group consisting of: hydrogen, halogen, nitrile, OR', C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl and C ₃ -C ₈ -cycloalkyl; R ^a and R ^b are independently selected from the group consisting of hydrogen, halogen, nitrile, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkene C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl and C ₃ -C ₈ -cycloalkyl; D is selected from the group consisting of: NR ⁵ R ⁶ , -N= S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), C ₆ -C ₁₀ -aryl and C ₃ -C ₁₀ -heterocyclyl; wherein, aryl and heterocyclyl can be optionally substituted by one or more R ^D groups; R ^D is selected from the group consisting of: halogen, CN, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₂ -C ₆ -Haloalkynyl, OR ⁴ , C ₁ -C ₆ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₆ -alkyl-C(=O)-R′′, NR 'R'', C ₁ -C ₆ -Alkyl-NR'R'', C(=O)-NR'R'', C ₁ -C ₆ -Alkyl-C(=O)-NR'R '', S(O) _n R'', C ₁ -C ₆ -alkyl-S(O) _n R'', CR'=NR'', C ₃ -C ₈ -cycloalkyl, C ₃ - C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl and Si(R′) ₃ ; R ⁴ is selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₃ -C ₈ -cycloalkyl, C(=O)- R'', C ₁ -C ₆ -alkyl-C(=O)-R'', C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl and C ₃ -C ₈ -heterocyclyl; wherein each R ⁴ group is optionally substituted with one or more groups selected from the group consisting of: halogen, CN, R'', OR'', SR '', N(R'R'') and Si(R') ₃ ; R ⁵ is selected from the group consisting of: C ₁ -C ₈ -alkyl, C ₁ -C ₈ -cyanoalkyl , C _{2 -C 8} -alkenyl, C ₂ -C 8 -alkynyl, C ₁ -C ₈ -haloalkyl, C ₂ -C ₈ -haloalkenyl, C ₂ -C ₈ -haloalkynyl, OR ^4. C ₁ -C ₈ -Alkyl-OR ⁴ , C(=O)-R'', C ₁ -C ₈ -Alkyl-C(=O)-R'', NR'R'', C ₁ -C ₆ -Alkyl-NR′R′′, C(=O)-NR′R′′, C ₁ -C ₈ -Alkyl-C(=O)-NR′R′′, C ₂ - C ₆ -alkenyl-C(=O)-N(R′R′′), C ₁ -C ₈ -alkyl-S(O) _n R ⁴ , S(O) _n R ⁴ , CR′=NR '', C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -nitrile cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl, C ₃ -C ₈ - Nitrile cycloalkyl-C ₁ -C ₈ -alkyl, C ₄ -C ₈ -cycloalkenyl, C ₄ -C ₈ -cycloalkynyl, bicyclic C ₅ -C ₁₂ -alkyl, bicyclic C ₇ -C ₁₂ -Alkenyl, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocycle Group-C ₁ -C ₆ -alkyl; wherein each group is optionally substituted by one or more R ^5a groups; R ^5a is selected from the group consisting of halogen, CN, C ₁ -C ₆ -Alkyl, C ₂ -C ₆ -Alkenyl, C ₂ -C ₆ -Alkynyl, C ₁ -C ₆ -Haloalkyl, C ₂ -C ₆ -Haloalkenyl, C ₂ -C ₆ -haloalkynyl, OR ⁴ , C ₁ -C ₆ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₆ -alkyl-C(=O)-R′′, NR′R′′, C ₁ -C ₆ -Alkyl-NR′R′′, C(=O)-NR′R′′, C ₁ -C ₆ -Alkyl-C(=O)-NR′ R'', S(O) _n R'', C ₁ -C ₆ -Alkyl-S(O) _n R'', CR'=NR'', C ₃ -C ₈ -Cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₆ -alkyl and Si(R') ₃ ; R ⁶ is selected from the group consisting of hydrogen, C ₁ -C ₈ -alkyl, C ₂ - C ₈ -alkenyl, C ₂ -C ₈ -alkynyl, C ₁ -C ₈ -haloalkyl, C ₂ -C ₈ -haloalkenyl, C ₂ -C ₈ -haloalkynyl, OR ⁴ , C ₁ -C ₆ -alkyl-OR ⁴ , C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl, Si(R′) ₃ and (C=O )-R''; or R ⁵ and R ⁶ substituents can form together with the atoms they are connected to -N=S(O) _0-1 R ^8a R ^8b group; or R ⁵ and R ⁶ substituents are connected to them Atoms or together with other atoms may form a three- to seven-membered ring selected from the group consisting of: C, N, O, S, and optionally contain 1 to 3 members selected from the group consisting of C (= O), C (= S), S (O) _0-2 and Si (R ') ₂ ring members of the group consisting of, the part of the three to seven member ring is selectively replaced by one or more R ⁷ group substitution; R ⁷ is selected from the group consisting of: halogen, nitrile, SCN, nitro, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, SF ₅ , OR ⁴ , C ₁ -C ₈ -alkyl-OR ^4. NR'R'', C ₁ -C ₈ -alkyl-NR'R'', Si(R') ₃ , (C=O)-R'', C ₁ -C ₈ -alkyl-( C=O)-R'', S(O) _n R'', C ₁ -C ₈ -alkyl-S(O) _n R'', CR'=NR'', C ₃ -C ₈ -ring Alkyl and C ₃ -C ₈ -cycloalkyl-C ₁ -C ₄ -alkyl; Or, two R ⁷ substituents can form a three- to six-membered ring with the atoms to which they are attached or with other atoms, and the other Atoms are selected from the group consisting of: C, N, O, S, and optionally contain 1 to 3 atoms selected from C(=O), C(=S), S(O) _0-2 and The ring member of the group consisting of Si(R') ₂ , the part of the three to six membered ring is optionally substituted by one or more groups selected from the group consisting of: halogen, CN, R'' , OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; R ^8a is selected from the group consisting of: C ₁ -C ₆ -alk C ₂ -C ₆ -alkenyl, C _{2 -C} 6 -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₃ -C ₈ -cycloalkyl, C ₁ -C ₆ -alkyl-C(=O)-R′′, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein each R ^8a group is selectively selected from one or more groups consisting of Substitution: Halogen, CN, R'', OR'', S(O) _0-2 R'', NR'R'', Si(R') ₃ , COOR' and CON(R') ₂ ; R ^8b is selected from the group consisting of: C ₁ -C ₆ -alkyl or C ₃ -C ₆ -cycloalkyl; or the R ^8a and R ^8b substituents and the atoms to which they are attached or together with other atoms may form a triple To a six-membered ring, the other atoms are selected from the group consisting of C, N, O, S, and optionally contain 1 to 3 atoms selected from C(=O), C(=S), S (O) _0-2 and Si(R') The ring member of the group consisting of ₂ , the part of the three to six membered ring is optionally substituted by one or more groups selected from the group consisting of: Halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; each of R ² , R ³ , R ⁴ , R ^5. The R ⁶ and R ⁷ groups can be optionally substituted by one or more groups consisting of: halogen, CN, R'', OR'', SR'', NR'R'' , Si(R') ₃ , COOR' and CONR'R'';R' is selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl and C ₃ -C ₈ -cycloalkyl; wherein, alkyl, alkenyl and cycloalkyl are optionally substituted by one or more halogens; R'' is selected from the following The group consisting of: hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₈ - Cycloalkyl, N(R') ₂ , OR', phenyl, benzyl and C ₃ -C ₈ -heterocyclyl; each R'' group may optionally be selected from the group consisting of Substitution by one or more groups: halogen, R', CN, OR', SR', N(R') ₂ , Si(R') ₃ , COOR' and CON(R') ₂ ; m and n represent integers 0, 1 or 2; p and q denote the integers 0, 1 or 2; provided that p and q cannot simultaneously denote the integer 0; or agriculturally acceptable salts, stereoisomers, diastereomers, enantiomers thereof Conformers, tautomers, metal complexes, polymorphs or N-oxides.

In one embodiment, ring Q represents a C ₅ -C ₆ -heterocyclyl optionally substituted by one or more R ³ groups.

In a preferred embodiment, ring Q is selected from the group consisting of furanyl (furanyl), thienyl (thienyl), pyrrolyl (pyrrolyl), pyrazolyl (pyrazolyl), imidazolyl (imidazolyl) , pyridinyl (pyridinyl), pyrimidinyl (pyrimidinyl), pyrazinyl (pyrazinyl), pyridazinyl (pyridazinyl), which can be optionally substituted by one or more R ³ groups.

In a more preferred embodiment, ring Q is selected from the group consisting of thienyl (thienyl), pyridinyl (pyridinyl), pyrimidinyl (pyrimidinyl), pyrazinyl (pryazinyl) or pyridazinyl (pyridazinyl) ), which are optionally substituted by one or more ^R groups.

In a more preferred embodiment, ring Q is selected from the group consisting of thienyl (thienyl), pyrimidinyl (pyrimidinyl) or pyridinyl (pyridinyl), which can be optionally replaced by one or more R ³ groups are substituted.

In a more preferred embodiment, Snippets are selected from the group consisting of: and ; Wherein, * is the connection point (point of attachment) of oxazoline ring, # is the connection point of fragment-(A) _0-1 -D.

In one embodiment of the present invention, a compound of formula (I) is provided, wherein, A represents direct bond (direct bond), D represents NR ⁵ R ⁶ , -N=S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), phenyl or C ₃ -C ₈ -heterocyclyl; among them, phenyl and heterocyclyl Optionally substituted with one or more R ^D groups.

In one embodiment of the present invention, a compound of formula (I) is provided, wherein A represents C(=O), and D represents NR ⁵ R ⁶ or -N=S(O) _0-1 R ^8a R ^8b .

In one embodiment of the present invention, a compound of formula (I) is provided, wherein A represents CR ^a R ^b , D represents NR ⁵ R ⁶ , -N=S(O) _0-1 R ^8a R ^8b , OR ^4. S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), phenyl or C ₃ -C ₈ -heterocyclyl; among them, phenyl and heterocyclyl are optional is substituted with one or more R ^D groups.

In one embodiment of the present invention, a compound of formula (I) is provided, wherein the preferred -AD group is selected from the group consisting of: -N=S(O) _0-1 R ^8a R ^8b , -OR ⁴ , -S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), -S(O) _n C ₁ -C ₆ -alkyl-C(=O )-R'', -C(=O)NR ⁶ C ₁ -C ₈ -alkyl, -C(=O)NR ⁶ C ₃ -C ₆ -cycloalkyl, -C(=O)NR ⁶ CR '=NR'', -C(=O)NR ⁶ CR ^a R ^b C(=O)NR'R'', -C(=O)NR ⁶ CR ^a R ^b C(=O)OR', - C(=O)NR ⁶ C ₃ -C ₈ -heterocyclyl, -C(=O)NR ⁶ CR ^a R ^b C ₃ -C ₈ -heterocyclyl, -C(=O)NR ⁶ (CR ^a R ^b ) ₂ OR ⁴ , -C(=O)NR ⁶ (CR ^a R ^b ) ₂ S(O) _n R′′, -C(=O)NR ⁶ C ₃ -C ₈ -heterocyclyl-S (O) _n R'', -CR ^a R ^b NR ⁶ C(=O)R'' and CR ^a R ^b C ₃ -C ₈ -heterocyclyl; wherein, the heterocyclyl can be optionally replaced by one or Multiple R ^D groups are substituted.

In one embodiment of the present invention, a compound of formula (I) is provided, wherein Cy is phenyl.

In one embodiment, the present invention provides a compound of formula (Ia) or a salt thereof, Formula (Ia) wherein, the R ¹ substituent is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are selected from hydrogen or halogen; R ³ , A and D substituents are as defined above.

In one embodiment, the present invention provides a compound of formula (Ia-1) or a salt thereof, Formula (Ia-1) wherein, R ¹ substituent is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are selected from hydrogen or halogen; R ³ and D substituents are as defined above.

In one embodiment, the present invention provides a compound of formula (Ia-1-1) or a salt thereof, wherein A represents a direct bond, and D represents NR ⁵ R ⁶ .

In one embodiment, the present invention provides a compound of formula (Ia-1-2) or a salt thereof, wherein A represents a direct bond, and D represents N=S(O) _0-1 R ^8a R ^8b .

In one embodiment, the present invention provides a compound of formula (Ia-1-3) or a salt thereof, wherein A represents a direct bond, and D represents OR ⁴ .

In one embodiment, the present invention provides a compound of formula (Ia-1-4) or a salt thereof, wherein A represents a direct bond, and D represents S(O) _n R ⁵ .

In one embodiment, the present invention provides a compound of formula (Ia-1-5) or a salt thereof, wherein A represents a direct bond, and D represents -S(O) _0-1 R ^8a (=NR ^8a ).

In one embodiment, the present invention provides a compound of formula (Ia-1-6) or a salt thereof, wherein, A represents a direct bond, D represents C ₆ -C ₁₀ -aryl or C ₃ -C ₁₀ -hetero Ring base.

Among them, NR ⁵ R ⁶ , N=S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), C ₆ -C ₁₀ -aryl and C ₃ -C ₁₀ -heterocyclyl are as defined above.

In another embodiment, the present invention provides a compound of formula (Ia-2) or a salt thereof, Formula (Ia-2) wherein, the R ¹ substituent is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are selected from hydrogen or halogen; R ³ , R ⁵ , R ⁶ and W substituents is as defined above.

In one embodiment, the present invention provides a compound of formula (Ia-2-1) or a salt thereof, wherein A represents -C(=W)-, and D represents NR ⁵ R ⁶ .

In one embodiment, the present invention provides a compound of formula (Ia-2-2) or a salt thereof, wherein, A represents -C(=W)-, D represents -N=S(O) _0-1 R ^8a R ^8b .

In one embodiment, the present invention provides a compound of formula (Ia-2-3) or a salt thereof, wherein A represents -C(=W)-, and D represents OR ⁴ .

In one embodiment, the present invention provides a compound of formula (Ia-2-4) or a salt thereof, wherein A represents -C(=W)-, and D represents NR ⁶ S(O) _n R ⁵ .

In one embodiment, the present invention provides a compound of formula (Ia-2-5) or a salt thereof, wherein, A represents -C(=W)-, D represents C ₆ -C ₁₀ -aryl and C ₃ - C ₁₀ -heterocyclyl.

Among them, W, NR ⁵ R ⁶ , -N=S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , C ₆ -C ₁₀ -aryl and C ₃ -C ₁₀ - The heterocyclyl group is as defined above.

In a preferred embodiment, the present invention provides a compound of formula (Ia-2-1) or a salt thereof, Formula (Ia-2-1) wherein, R ¹ is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are independently selected from hydrogen or halogen; Ring Q is selected from the group consisting of Group: thienyl (thienyl), pyridinyl (pyridinyl), pyrimidinyl (pyrimidinyl), pyrazinyl (pyrazinyl) and thiazolyl (thiazolyl), which are optionally substituted by one or more ^R groups; R ³ is selected from the group consisting of halogen, nitrile, C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkenyl, C ₂ -C ₆ -alkynyl, C ₃ -C ₄ - Cycloalkyl and OR'; wherein, R ³ is optionally substituted by one or more halogen, OR' or nitrile; R ⁵ is selected from the group consisting of: C ₁ -C ₈ -alkyl , C ₁ -C ₈ -cyanoalkyl, C ₂ -C ₈ -alkenyl, C ₂ -C ₈ -alkynyl, C ₁ -C ₈ -haloalkyl, C ₂ -C ₈ -haloalkenyl, C ₂ -C ₈ -haloalkynyl, OR ⁴ , C ₁ -C ₈ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₈ -alkyl-C(=O)- R'', NR'R'', NR'-C(=O)-R', C ₁ -C ₆ -alkyl-NR'R'', C(=O)-NR'R'', C1 -C8-Alkyl-C(=O)-NR′R′′, C ₂ -C ₆ -alkenyl-C(=O)-N(R′R′′), C ₁ -C ₈ -Alkyl -S(O) _n R ⁴ , S(O) _n R ⁴ , CR′=NR′′, C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cyanocycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl, C ₃ -C ₈ -nitrile cycloalkyl-C ₁ -C ₈ -alkyl, C ₄ -C ₈ -cycloalkenyl, C ₄ -C ₈ -Cycloalkynyl, bicyclic C ₅ -C ₁₂ -alkyl, bicyclic C ₇ -C ₁₂ -alkenyl, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ - Alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein, R ⁵ is optionally selected from the group consisting of Substituted by one or more groups: halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; R ⁴ series selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₃ -C ₈ -cycloalkyl, C(=O)-R′′, C ₁ -C ₆ -alkyl-C(=O)-R′′, COOR′, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl and C ₃ -C ₈ -heterocyclyl; wherein each R ⁴ group is optionally replaced by Substituted by one or more groups selected from the group consisting of: halogen, CN, R'', OR'', SR'', N(R'R'') and Si(R') ₃ ; R ⁶ is selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, OR ⁴ , C ₁ -C ₄ -alkyl-OR ⁴ , C ₃ -C ₈ -cycloalkyl, C ₃ - C ₈ -cycloalkyl-C ₁ -C ₄ -alkyl, Si(R') ₃ and (C=O)-R''; wherein, R ⁶ can optionally be replaced by one or more halogen or nitrile substituents; R ⁵ and R ⁶ substituents can form three to seven membered rings with the atoms they are connected to or with other atoms, and the other atoms are selected from the group consisting of: C, N, O, S, and Optionally comprising 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O) _0-2 and Si(R') ₂ , the three to seven members Parts of the ring are optionally substituted by one or more R ⁷ groups; R ⁷ is selected from the group consisting of: halogen, nitrile, nitro, C ₁ -C ₆ -alkyl, C ₂ - C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, OR ⁴ , C ₁ -C ₈ -Alkyl-OR ⁴ , NR′R′′, C ₁ -C ₈ -Alkyl-NR′R′′, Si(R′) ₃ , (C=O)-R′′, C ₁ -C ₈ -Alkyl-(C=O)-R′′, S(O) _n R′′, C ₁ -C ₈ -Alkyl-S(O) _n R′′, CR′=NR′′ , C ₃ -C ₈ -cycloalkyl and C ₃ -C ₈ -cycloalkyl-C ₁ -C ₄ -alkyl; wherein, R ⁷ is optionally selected from one of the group consisting of Or multiple substitutions: halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; or, two R ^{The 7} substituent may form a three to six membered ring with the atom to which it is attached or with other atoms selected from the group consisting of: C, N, O, S, and optionally comprising 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O) _0-2 , and Si(R') ₂ , portions of the three to six membered rings are optional is substituted by one or more groups consisting of: halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; Alternatively, the R ⁵ and R ⁶ substituents and the atoms to which they are attached may together form a N=S(O) _0-1 R ^8a R ^8b group; R ^8a is selected from the group consisting of: C ₁ -C ₆ -Alkyl, C ₂ -C ₆ -Alkenyl, C ₂ -C ₆ -Alkynyl, C ₁ -C ₆ -Haloalkyl, C ₂ -C ₆ -Haloalkenyl, C ₃ -C ₈ -cycloalkyl, C ₁ -C ₆ -alkyl-C(=O)-R'', C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alk C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein each R ^8a group is optionally selected from the group consisting of One or more groups are substituted: halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CON(R') ₂ ; R ^8b is is selected from the group consisting of: C ₁ -C ₆ -alkyl and C ₃ -C ₆ -cycloalkyl; R' is selected from the group consisting of: hydrogen, C ₁ -C ₆ -alkyl , C ₂ -C ₆ -alkenyl and C ₃ -C ₈ -cycloalkyl; wherein, alkyl, alkenyl and cycloalkyl are optionally substituted by one or more halogens; R'' is selected from The group consisting of hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₈ -cycloalkyl, N(R ') ₂ , OR', phenyl, benzyl and C ₃ -C ₈ -heterocyclyl; each R'' group may be optionally substituted by one or more groups selected from the group consisting of : halogen, R', CN, OR', SR', N(R') ₂ , Si(R') ₃ , COOR' and CON(R') ₂ ; W is selected from the following groups: O, S or NR ⁹ ; or an agriculturally acceptable salt, stereoisomer, diastereomer, enantiomer, tautomer, metal complex, polymorph or N-oxide thereof.

In a preferred embodiment, the present invention provides a compound of formula (Ia-2-1a), Formula (Ia-2-1a) wherein, R ¹ , R ^2a , R ^2b , R ^2c , R ³ , R ⁴ , R ⁵ and W are as defined above in the detailed description.

In a more preferred embodiment, the present invention provides a compound of formula (Ia-2-1b), Formula (Ia-2-1b) wherein, A ¹ , A ² and A ³ represent C or N; provided that at least one of A ¹ , A ² and A ³ represents N; R ¹ , R ^2a , R ^2b , R ^2c , ^R3 , ^R4 , ^R5 and W are as defined in the above detailed description.

In yet another embodiment, the present invention provides a compound of formula (Ia-3), Formula (Ia-3) wherein, R ¹ substituent is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are selected from hydrogen or halogen; R ³ , R ^a , R ^b and D are such as as defined above.

In one embodiment, the present invention provides a compound of formula (Ia-3-1) or a salt thereof, wherein A represents -CR ^a R ^b -, and D represents NR ⁵ R ⁶ .

In one embodiment, the present invention provides a compound of formula (Ia-3-2) or a salt thereof, wherein, A represents -CR ^a R ^b -, D represents -N=S(O) _0-1 R ^8a R ^8b .

In one embodiment, the present invention provides a compound of formula (Ia-3-3) or a salt thereof, wherein A represents -CR ^a R ^b - and D represents OR ⁴ .

In one embodiment, the present invention provides a compound of formula (Ia-3-4) or a salt thereof, wherein A represents -CR ^a R ^b -, and D represents S(O) _n R ⁵ .

In one embodiment, the present invention provides a compound of formula (Ia-3-5) or a salt thereof, wherein, A represents -CR ^a R ^b -, D represents -S(O) _0-1 R ^8a (=NR ^8a ).

In one embodiment, the present invention provides a compound of formula (Ia-3-6) or a salt thereof, wherein, A represents -CR ^a R ^b -, D represents C ₆ -C ₁₀ -aryl and C ₃ -C ₁₀ -heterocyclyl.

Among them, W, R ^a , R ^b , NR ⁵ R ⁶ , -N=S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), C ₆ -C ₁₀ -aryl and C ₃ -C ₁₀ -heterocyclyl are as defined above.

In a preferred embodiment, R ¹ is selected from CH ₂ F, CHF ₂ , CF ₂ CH ₃ or CF ₃ . More preferably, CF ₃ .

In a preferred embodiment, R ^2a and R ^2c are halogen.

In a preferred embodiment, R ^2b is hydrogen or halogen.

In a preferred embodiment, R ³ is hydrogen or methyl. More preferably, methyl.

In a preferred embodiment, p and q represent the integer 1.

In a preferred embodiment, R ⁵ , R ⁶ or D is cycloalkyl or heterocycle; the above cycloalkyl or heterocycle is selected from C-1 to C-56:

In yet another embodiment, the present invention provides a compound of formula (A), Formula (A) wherein, Z is selected from the group consisting of: OH, NH ₂ , SH, X, CN and leaving group (leaving group); wherein, X represents halogen; R ¹ is selected from the group consisting of The group of: C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl and C ₃ -C ₆ -halocycloalkyl; Cy is selected from the following The group consisting of: phenyl and C ₅ -C ₆ -heterocyclyl, which is optionally substituted by one or more R ² groups; wherein R ² is selected from the group consisting of: hydrogen , Halogen, Nitrile, C ₁ -C ₆ -Alkyl, C ₂ -C ₆ -Alkenyl, C ₂ -C ₆ -Alkynyl, C ₁ -C ₆ -Haloalkyl, C ₂ -C ₆ -Halo Alkenyl and C ₃ -C ₈ -cycloalkyl; R ³ is selected from the group consisting of hydrogen, halogen, nitrile, nitro, C ₁ -C ₄ -alkyl, C ₂ -C ₄ - Alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₄ -haloalkyl, C ₂ -C ₄ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, C ₃ -C ₄ -cycloalkane radical, C ₃ -C ₅ -heterocyclyl, -OC ₃ -C ₄ -heterocyclyl, SCN, SF ₅ , NR′R′′, OR′, S(O) _n R′ and CR′=NR′ '; p and q represent the integers 0, 1 or 2; provided that p and q cannot simultaneously represent the integer 0; or an agriculturally acceptable salt, stereoisomer, diastereomer, enantiomer, enantiomer, or Isomers, metal complexes, polymorphs or N-oxides.

In one embodiment, the leaving group described in the compound of formula (A) is selected from: halides (such as fluorides, chlorides, bromides and iodides), esters, thioesters, phosphates, sulfates, Sulfinate, sulfonate, alkoxycarbonyloxy, aryloxycarbonyloxy, alkanesulfonyloxy, arenesulfonyloxy, alkyl-carbonyl Alkyl-carbonyloxy (e.g. acetoxy), arylcarbonyloxy, aryloxy, methoxy, N,O-dimethylhydroxylamine (N,O-dimethylhydroxylamino), phenyl xanthenyl (pixyl) and haloformates. In some cases, this leaving group is a sulfonate, such as para-toluenesulfonate (tosylate, -OTs), methanesulfonate (mesylate, -OMs), p-bromobenzene Sulfonyloxy (p-bromobenzenesulfonyloxy) (brosylate, -OBs) or trifluoromethanesulfonate (trifluoromethanesulfonate) (triflate, -OTf), etc. Preferably, halide, methoxyl, tosylate (-OTs), mesylate (-OMs) or trifluoromethanesulfonate (triflate, -OTf).

In a preferred embodiment of the present invention, the present invention provides a compound of formula (I), wherein R ⁵ is selected from the group consisting of: C ₁ -C ₈ -alkyl, C ₁ -C ₆ -Alkyl-OR ⁴ , C ₁ -C ₆ -Alkyl-S(O) _n R ⁴ , C ₁ -C ₆ -Alkyl-NR′R′′, C ₁ -C ₆ -Alkyl-C( =O)-R'', C ₁ -C ₆ -alkyl-C(=O)-NR'R'', CR'=NR'', C ₁ -C ₆ -cyanoalkyl, C ₃ - C ₈ -cycloalkyl, C ₃ -C ₈ -cyanocycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl, C ₃ -C ₈ -cyanocycloalkyl- C ₁ -C ₈ -alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein, R ⁵ can be optionally replaced by one or Multiple halogen or nitrile substitutions.

In a preferred embodiment of the present invention, a compound of formula (I) is provided, wherein R ⁶ is selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, OR ⁴ , C ₁ -C ₄ -alkyl-OR ⁴ , C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₄ -alkyl, Si(R′) ₃ and (C=O )-R''.

In one embodiment of the present invention, preferred aromatic/non-aromatic heterocyclic rings are selected from the group consisting of: pyridinyl (pyridinyl), pyrimidinyl (pyrimidinyl), pyrazinyl (pyrazinyl), pyridyl Pyridazinyl, 1,2,4-triazinyl (1,2,4-triazinyl), 1,3,5-triazinyl (1,3,5-triazinyl), furanyl (furanyl), Tetrahydrofuranyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl (1,2,3-triazolyl), 1,2,4-triazolyl (1,2,4-triazolyl), tetrazolyl (tetrazolyl), oxazolyl (oxazolyl), thiazolyl (thiazolyl), isoxazolyl (isoxazolyl), isothiazolyl (isothiazolyl), isoxazolidinyl (isoxazolidinyl), isoxazolidinyl (isoxazolidinyl), 4,5-dihydroisoxazolyl (4,5-dihydroisoxazolyl), 1,2,3-oxadiazolyl (1,2,3-oxadiazolyl), 1,2,4-oxadiazolyl (1,2,4-oxadiazolyl), 1,3,4-oxadiazolyl (1,3,4-oxadiazolyl), 1,2,3-thiadiazolyl (1,2,3-thiadiazolyl), 1,2,4-thiadiazolyl (1,2,4-thiadiazolyl) or 1,3,4-thiadiazolyl (1,3,4-thiadiazolyl), azetidinyl, thietanyl, 1-thietanyl 1-oxide, oxetanyl ), 4,5-dihydroisoxazolyl (4,5-dihydroisoxazolyl), pyrrolidinyl (pyrrolidinyl), pyrrolidinyl-2-one (pyrrolidinyl-2-one), 1-pyrrolidinyl-2,5 -Diketone (1-pyrrolidinyl-2,5-dione), 1-pyrrolidinyl-2-one (1-pyrrolidinyl-2-one), tetrahydropyranyl (tetrahydropyranyl), isoxazolidinyl-3- Ketone (isoxazolidinyl-3-one), imidazolidinyl-2-one (imidazolidinyl-2-one), 2-thioxothiazolidinyl-4-one (2-thioxothiazolidinyl-4-one), tetrahydrofuryl (tetrahydrofuryl) , tetrahydrothiopyranyl, piperidinyl, piperidinyl-2-one, piperidinyl-2,6-dione and morpholinyl (morpholinyl); each heterocyclic ring system is unsubstituted or substituted by a substituent independently selected from the group consisting of: nitrile, nitro, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ Alkylsulfinyl, C ₁ -C ₆ Haloalkylsulfinyl, C ₁ -C ₆ Alkylsulfinyl, C ₁ -C ₆ Haloalkylsulfinyl, Si(R′) ₃ , COOR' and CON(R'R'').

In one embodiment of the present invention, the compound of formula (I) is selected from: 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl))-N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -(2,2,2-Trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-(thiophen-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide); N-(cyclopropylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3, N -(2-Cylonitrile ethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- N-(2-cyanoethyl)-5-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl- 3-oxyisoxazolin-4-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-5,6-dihydro -4H-thieno[2,3-c]pyrrole-2-carboxamide); N-cyclobutyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl base)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclobutyl-5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -Propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-cyclopropyl-5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(tert-butyl)-5-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-Formamide (N-(tert-butyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5, 6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-N-isobutyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyclopropylethyl)-5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-formyl Amine (N-(1-cyclopropylethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro- 4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c] pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(2-methoxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (1-(trifluoromethyl)cyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(trifluoromethyl)cyclopropyl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(oxetan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide); N-cyclopentyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopentyl-5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-cyclohexyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclohexyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isoamyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiazol-2-ylmethyl)-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclopentylmethyl)-5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thiophene And[2,3-c]pyrrole-2-carboxamide (N-(cyclopentylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,2 -Trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide); (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6 -Dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3,3-difluoroazetidin-1-yl)methanone ((5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3,3-difluoroazetidin -1-yl)methanone); N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyanocyclopropyl)-5 -(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclopropyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyclopropylethyl)-5-(5-(3,5-dichloro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- Formamide (N-(1-cyclopropylethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H- thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-5,6 -Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2- methoxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-Formamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)- 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-Dihydroisoxazol-3-yl)-N-isobutyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ); N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-Formamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- carboxamide); N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- base)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-5,6-dihydro-4H-thieno[2,3- c] pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-5,6-dihydro- 4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-N-isopropoxy-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-( 5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -isopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ( N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c] pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl Base-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichlorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); N-(cyclopropylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopropylmethyl)-2-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(cyclobutylmethyl)-2 -(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide (N-(cyclobutylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(cyclopentylmethyl)-2-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ( N-(cyclopentylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); N-(1-cyanocyclobutyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclobutyl)-2-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N- (1-cyanocyclopentyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopentyl)-2-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(cyclobutylmethyl)-5-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide (N-(cyclobutylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclopentylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(tri Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopentylmethyl )-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2, 2-Difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-( 5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3- Pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ; 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1- Trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R) -2-Ethyl-3-oxyisoxazolidin-4-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-3-methyl-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl -N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5- Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-3-methyl Base-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5 -(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3- Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-ethyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2 ,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(cyanomethyl)-2-(5-(3,5-dichlorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-( cyanomethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophene -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5- (3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-2,3-dihydro-1H-pyrrole And[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl- 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-cyclopropyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N -cyclopropyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-(thietane-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ( 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)- 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -3-methyl-N-(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxy (2-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide); N-(2-cyanobut-2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl base)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanobutan -2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -(2-fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5 -(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pent-3-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(pentan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-allyl-2-(5-(3,5 -Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (N-allyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-N-(3,3-difluorocyclobutyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-methyl Amide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-difluorocyclobutyl)-3-methyl -5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl Base)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-3-methyl-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylthio )ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(prop-2-yn-1-yl))-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -3-methyl-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(tert-butyl)- 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(tert-butyl)-5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-propyl-5, 6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-3-methyl-N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-((1-cyanocyclopropyl )methyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-((1-cyanocyclopropyl)methyl)-5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxyl-2-(( 2,2,2-Trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-oxyl-2-((2,2,2-trifluoroethyl)amino )ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyanocyclobutyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N- (1-cyanocyclobutyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide); N-(1-cyanocyclopentyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1- cyanocyclopentyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-(oxetane-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-N-(thiophen-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-((R)-2-ethyl-3-oxyisoxazolidin-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2- ethyl-3-oxoisoxazolidin-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxyl-2-((2,2,2-trifluoroethyl base)amino)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-N-(oxetan-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formyl Amine (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-ylmethyl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-N-isoamyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5- (5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran- 2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide); N-cyclohexyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclohexyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbut-2-yl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(thien-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-methyl Amide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-N-(3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ( 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carba Amide (N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclopropylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -Formamide (N-(cyclopropylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(2-nitrile ethyl)-2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formyl Amine (N-(2-cyanoethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-cyclopentyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopentyl-5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5 -(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(5-methylhex-2-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(5-methylhexan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5 -Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbutyl)-5,6-dihydro-4H -Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (2-methylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylthio)ethyl)-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3 -methyl-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(prop-2-yn-1-yl)-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3 ,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-3-methyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(2-methoxyethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5 -Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3-methyl-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl -3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclopropylmethyl)-5-(5-(3,5-dichloro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)-5-(three Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide); N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 3-Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-3- Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N- (Nitrylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methanol N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5 -Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-propyl-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl -N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl Base)-4,5-dihydroisoxazol-3-yl)-N-(2-oxyl-2-((2,2,2-trifluoroethyl)amino))ethyl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-N-neopentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4- c] Pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-2, 3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N,3-dimethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5 -(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N,3-dimethyl-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide); N-(1-cyanocyclopropyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopropyl)-2- (5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ; N-cyclopropyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3 -Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclopropyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(tri Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formyl Amine (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -(2-Methoxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N- Cyclobutyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclobutyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N,3-dimethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N,3-dimethyl-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 3-Methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2- (5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-2,3-dihydro -1H-Pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-isopropyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-2, 3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan- 2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl Base)-4,5-dihydroisoxazol-3-yl)-N-(3,3-difluorocyclobutyl)-2,3-dihydro-1H-pyrrolo[3,4-c] Pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-difluorocyclobutyl)-2, 3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3- c] pyrrole-2-formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyanocyclobutyl)-5-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-formamide (N-(1-cyanocyclobutyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(4-methylthiazol-5-yl)ethyl)-5,6-dihydro -4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-(2-(4-methylthiazol-5-yl)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-pentyl-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-pentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyanocyclohexyl)-5-(5-(3,5 -Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide (N-(1-cyanocyclohexyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(three Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2- difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclobutylmethyl)-5-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- Formamide (N-(cyclobutylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro- 4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxyisoxazolin-4-yl)-3-methyl-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thiophene And[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6- dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-N-(2,2-difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2- (5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(pyridin-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridin-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ); N-((1-cyanocyclopropyl)methyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-((1-cyanocyclopropyl)methyl)-2-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N- (tert-butyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(tert-butyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(2-nitrile ethyl)-2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide (N-(2-cyanoethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-butyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-butyl-2-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2 -(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl base)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin- 3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutyl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3 ,3-dimethylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-butyl-5-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- Formamide (N-butyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H- thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3, 5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl Base) azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-formyl Amine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- Formamide (N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro- 4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxypyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1- methyl-2,5-dioxopyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-allyl-5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c] Pyrrole-2-carboxamide (N-allyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H- thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide); N-(2-cyclopentylethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2-cyclopentylethyl)-5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoroethyl)-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(2-fluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-butyl-5-(5-(3,5-dichlorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-methyl Amide (N-butyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide); N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-di Chlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazole-2- Base)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (1-((Difluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-N-(2-oxyl-2-((2,2,2-trifluoroethyl)amino))ethyl)-5,6-dihydro -4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-( 5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl) -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetane-3-ylmethyl base)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1 -Nitrocyclopropyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclopropyl)-5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3 ,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxypyrrole Alk-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide); N-(2-nitrileethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2-cyanoethyl)-5-(5-(3,5-dichlorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5 -Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pent-2-yl)-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-( pentan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(tri Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)-5,6-dihydro-4H-thieno[2,3- c] Pyrrole-2-formamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)- 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-methoxy-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5 -(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide); Azetidin-1-yl (5-(5-(3,5-dichloro-4-fluorophenyl))-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)methanone (azetidin-1-yl(5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol- 2-yl)methanone); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-(1-((Difluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-methan Amide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin- 3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -(2,2,2-Trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-(3-methyloxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyloxetan-3-yl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide); N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(tri Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopropylmethyl )-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-N-(2-methoxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoro Methyl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-Dihydroisoxazol-3-yl)-N-isobutyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1 -Methyl-2,5-dioxypyrrolidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5 -(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(1-cyclopropylethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1- cyclopropylethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-carboxamide); N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopropyl-5-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy Base-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-( 1-methyl-2,5-dioxypyrrolidinyl)-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methyl-2,5-dioxopyrolidin-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-((trifluoromethyl)sulfonyl)azetidine-3- base)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (1-methoxyprop-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxypropan-2-yl)-3-methyl-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide); N-cyclopentyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopentyl-5-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ; (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6 -Dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3,3-difluoroazetidin-1-yl)methanone ((5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3 ,3-difluoroazetidin-1-yl)methanone); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isopropoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ; 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1 -Methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5 -(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1,1 ,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide); N-(1-cyclopropylethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyclopropylethyl )-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3 -Methyl-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -(2,2-Difluoroethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide); N-(1-cyanocyclopropyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclopropyl) -5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- Methoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiazole- 2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (3,3-Dimethylbut-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutan-2-yl)-3-methyl-5, 6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclopentylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-Formamide (N-(cyclopentylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl- 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(2-(cyclopropylamino)-2-oxoethyl)-2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide (N-(2-(cyclopropylamino)-2-oxoethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(2-(isobutylamino)-2-oxyethyl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( isobutylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methylcyclopropyl)-5,6-dihydro-4H -Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-((1-cyanocyclopropyl)methyl Base)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methan N-((1-cyanocyclopropyl)methyl)-5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(cyclobutylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclobutylmethyl)-5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(pent-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(pentan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-(2-(isobutylamino)-2-oxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(isobutylamino)-2-oxoethyl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-((1-cyanocyclopropyl)methyl)-2-(5-(3,5-dichloro-4- Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Formamide (N-((1-cyanocyclopropyl)methyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(2-fluoropyrrolidin-1-yl)methyl Ketone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin -6-yl)(2-fluoropyrrolidin-1-yl)methanone); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-3-methyl-N-(thietane-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thietan-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(3-methylbut-2-yl)-5,6-dihydro-4H-thiophene And[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 3-methyl-N-(3-methylbutan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-di Chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran- 2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol -2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbut-2-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3 -dimethylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-2 ,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(4-methylthiazol-5-yl)ethyl)-5,6-dihydro-4H -Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-N-(2-(4-methylthiazol-5-yl)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran -3-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran-3-yl)methyl)-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide); N-(2-cyclopentylethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2 -cyclopentylethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H- thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-3-methyl-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-formyl Amine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiophen-2-ylmethyl)- 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methylpyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl -N-(1-methylpyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 1-(2-(5-(3,5-di Chlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Carbonyl)piperidine-4-carbonitrile (1-(2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carbonyl)piperidine-4-carbonitrile); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-Dihydroisoxazol-3-yl)-3-methyl-N-(thietane-3-yl)-5,6-dihydro-4H-thieno[2,3-c] Pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thietan-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-3-methyl-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c] Pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiophen-2-ylmethyl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-3-methyl-N-(pent-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-Formamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(pentan-3-yl)- 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-Dihydroisoxazol-3-yl)-3-methyl-N-(2-methylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -Formamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-methylbutyl)-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -Formamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran-2-yl)methyl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thiophene And[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl- N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-cyclobutyl-5-(5 -(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H- Thieno[2,3-c]pyrrole-2-carboxamide (N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(1-cyanocyclohexyl)-2-(5-(3,5-di Chlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Formamide (N-(1-cyanocyclohexyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide); N-(1-cyclopropylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N- (1-cyclopropylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-N-(2-(methylthio)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-2,3-dihydro-1H- pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-3-methyl-N-(3-methylbut-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ( 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(3-methylbutan-2-yl)-5,6- dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-isoamyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-(2-fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ; N-(1-cyano-1-cyclopropylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyano-1-cyclopropylethyl)- 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(1,1,1-trifluoro-3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ( 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4- c] Pyridine-6-formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-cyclobutyl-2-(5-(3,5-dichloro-4-fluorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-methyl Amide (N-cyclobutyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-N-isopropyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ; N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pent-3-yl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(pentan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-yl)(3-fluoropyrrolidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-fluoropyrrolidin-1-yl)methanone); 5-(5-(3,5-dichlorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbut-2-yl)-3-methyl-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-N-(3,3-dimethylbutan-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5 -(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-3-methyl-5,6 -Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-isopropyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(5-methylhex-2-yl)-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3 -methyl-N-(5-methylhexan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 5-(5-(3,5-dichloro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-pentyl-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N- pentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(4,4-difluoropiperidine- 1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridin-6-yl)(4,4-difluoropiperidin-1-yl)methanone); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-N-((3,3-difluorocyclohexyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((3,3-difluorocyclohexyl)methyl)- 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N- ((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); 2-(5-(3,5-dichloro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylamino)-2-oxylethyl)-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-(2-(methylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3, 5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] Pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone); N-allyl-2 -(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-di Chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxypropan-2-yl)-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(1-methoxypropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridin-6-yl)(piperidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(piperidin-1-yl)methanone); 2-(5-(3,5- Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-2,3-dihydro-1H-pyrrole And[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-neopentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(2-nitrile ethyl)-2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide (N-(2-cyanoethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-N-methyl-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl- N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(hept-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(heptan-2-yl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(but-3-yn-2-yl)-2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] Pyridine-6-carboxamide (N-(but-3-yn-2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); azetidine-1 -yl(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3 -Dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone (azetidin-1-yl(2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone); N-(cyclopentylmethyl)-2 -(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopentylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-cyclohexyl-2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (N-cyclohexyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-N-(3,3-dimethylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutan-2- yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3- Difluoropiperidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropiperidin-1-yl)methanone); N-(2-cyclopentylethyl)-2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide (N-(2-cyclopentylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- ((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-N-(1-methoxybut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxybutan-2-yl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl Base)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4- c] Pyridine-6-formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro-2H -thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichlorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylamino)-2-oxyethyl)-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -3-methyl-N-(2-(methylamino)-2-oxoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); N-(tert-butyl)- 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(tert-butyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4- Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(pyridin-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxypyrrolidin-3-yl )-2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide); N-(1-cyanocyclohexyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclohexyl)-5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide); N-cyclopentyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclopentyl-2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-pentyl-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-pentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3,5-di Chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone); (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-( 2-(Methylamino)-2-oxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylamino)-2-oxoethyl)-5,6- dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide); (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropiperidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin- 6-yl)(3,3-difluoropiperidin-1-yl)methanone); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-N-(2-methylbut-3-yn-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbut-3-yn -2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4-difluorobenzyl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-( 2,4-difluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrole And[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-(4-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-2-(trifluoromethyl)benzyl)-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(4-fluoro-2-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5 -(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylamino )-2-oxylethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-methyl Amide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(3,5-dimethylisoxazol-4 -yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(2 -oxyl-7-azaspiro[3. 5] Non-7-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(2-oxa-7-azaspiro[3. 5] nonan-7-yl)methanone); (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone (( 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-N-(2-methylallyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-methyl Amide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylallyl)-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-N-(1,1-tetrahydrodioxide-2H-thiopyran-4-yl))-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1, 1-dioxidotetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2- (5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-3 -(trifluoromethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-3-(trifluoromethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-N-(2-oxypiperidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxopiperidin-3-yl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-N-((3-ethyloxetan-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c] Pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((3-ethyloxetan- 3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl) -2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide); N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-propyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopropylmethyl)-2- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-(2,4,6-trifluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4,6-trifluorobenzyl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide); N-(2-(cyclopropylamino)-2-oxoethyl)-2-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- Formamide (N-(2-(cyclopropylamino)-2-oxoethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(three Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-di Fluoropyrrolidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropyrrolidin-1-yl)methanone); N-(1-cyanocyclopropyl)-2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopropyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbut-3-yn-2-yl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbut- 3-yn-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(but-3-yn-2-yl)-2-(5 -(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide (N-(but-3-yn-2-yl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(2-nitrile ethyl)-2-(5-(3,5-di Chlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4- c] Pyridine-6-formamide (N-(2-cyanoethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-N-(3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-N-(3,5-difluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ( 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,5-difluorobenzyl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-N-(2,2-difluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoropropyl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-N-(1,1,1-trifluoro-2-methylprop-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro -2-methylpropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-(trifluoromethyl)oxetane-3-yl)-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-(3-(trifluoromethyl)oxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-(trifluoromethyl Base)pent-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-(trifluoromethyl)pentan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(1-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide); (3-amino-3-(trifluoromethyl)azetidin-1-yl)(2-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-yl)methanone ((3-amino-3-(trifluoromethyl)azetidin-1-yl)(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone); 2-(5-(3,5-dichloro-4-fluorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-2-methylbutan-2-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-2-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide); tert-butyl-2-(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)-1-methylhydrazine-1-carboxylate (tert-butyl 2-(2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carbonyl)-1-methylhydrazine-1-carboxylate); N-(3-cyanopent-3-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-( 3-cyanopentan-3-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-N-(tert-amyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tert-pentyl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-N-(3-methyltetrahydrofuran-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyltetrahydrofuran-3-yl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-N-(1-methoxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formyl Amine (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxy-2-methylpropan-2-yl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4,4-trimethylpent-2-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (2,4,4-trimethylpentan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3,3-trifluoropropyl)-2,3-dihydro-1H -Pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (3,3,3-trifluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5 -(Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(1,1,1-trifluoro-3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5- (3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1-dioxytetrahydro-2H-thio pyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methyl ylallyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(2-methylallyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylcyclopropyl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(2-methylcyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichlorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-(trifluoromethyl)cyclopropyl)methyl)-2,3-dihydro-1H -Pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- ((1-(trifluoromethyl)cyclopropyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(1-cyclopropyl-2,2,2- Trifluoroethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyclopropyl-2,2,2-trifluoroethyl)-2-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2 -(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1, 1-trifluorobut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluorobutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-((1-(hydroxymethyl)cyclobutyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2 -(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-(hydroxymethyl)cyclobutyl)methyl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-N-((4,4-difluorocyclohexyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((4,4-difluorocyclohexyl )methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); Methyl-2-cyclopropyl-2-(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formamido)propionate (methyl 2-cyclopropyl-2-(2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamido ) propanoate); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (1-(Hydroxymethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(hydroxymethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-(2,2,2-Trifluoro-1-(pyridin-2-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formyl Amine (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoro-1-( pyridin-2-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); N-(2-cyanoprop-2-yl)-2-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrole And[3,4-c]pyridine-6-carboxamide (N-(2-cyanopropan-2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4- Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-isopropyl-1H-pyrazol-4-yl)methyl )-2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-((1-isopropyl-1H-pyrazol-4-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide); 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1- Methylcyclopropyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-methylcyclopropyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -Neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide); N- Cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5, 6-Dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide); 5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H -Thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide); 5-(5-(3,5-dichloro-4- Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H -Thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide); 2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(ethoxymethyl)-N-(prop-2-yn- 1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(ethoxymethyl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide); ethyl (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)(prop-2-yn-1-yl)carbamate (ethyl (2- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carbonyl)(prop-2-yn-1-yl)carbamate); N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thiocarbamide ( N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carbothioamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-N-(3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thioamide (2- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carbothioamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thiocarbamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carbothioamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -Dihydroisoxazol-3-yl)-N-(2-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(trifluoromethyl)cyclopropyl)-2 ,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-Dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 - Thiocarbamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbothioamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl Base)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-thioamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbothioamide); 2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(methoxymethyl)-N-(prop-2-yn-1-yl)-2,3 -Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-N-(methoxymethyl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3 -Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide); 5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2- Trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- carbothioamide); N-cyclopropyl-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- base)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-cyclopropyl-6-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(1-cyanocyclopropyl )-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7- Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(1-cyanocyclopropyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(cyclopropylmethyl)-6-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H- Pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(cyclopropylmethyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(cyanomethyl)-6-(5-(3,5-di Chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d ]pyrimidine-2-carboxamide (N-(cyanomethyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6 ,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(1-cyanocyclobutyl)-6-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2- Formamide (N-(1-cyanocyclobutyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7- dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-Dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2- Formamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)- 6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl Base)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)(3,3-difluoroazol Heterobutan-1-yl)methanone ((6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7 -dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)(3,3-difluoroazetidin-1-yl)methanone); 6-(5-(3,5-dichloro-4-fluorobenzene Base)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,3,3,3-pentafluoropropyl)-6,7- Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(1,1,3,3,3-pentafluoropropyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1, 3,4-oxadiazol-2-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-6 ,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(2-cyclopentylethyl)-6-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2- Formamide (N-(2-cyclopentylethyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7- dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(1-cyanocyclohexyl)-6-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide ( N-(1-cyanocyclohexyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H- pyrrolo[3,4-d]pyrimidine-2-carboxamide); N-(4-cyanotetrahydro-2H-pyran-4-yl)-6-(5-(3,5-dichloro-4- Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2 -Formamide (N-(4-cyanotetrahydro-2H-pyran-4-yl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-methyltetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H -pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-(4-methyltetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5-(3,5 -Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(trifluoromethyl)cyclopropyl) -6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-(2-(trifluoromethyl)cyclopropyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl )sulfonyl)azetidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-6,7-dihydro- 5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-6,7-dihydro-5H-pyrrolo[ 3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N- (1-((difluoromethyl)sulfonyl)azetidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); 6-(5-(3,5-di Chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy-6,7-dihydro-5H-pyrrolo [3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N -methoxy-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide); N'-benzoyl-5-(5-(3,5-dichloro-4-fluoro Phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- Carbohydrazine (N'-benzoyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carbohydrazide); N'-acetyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (N'-acetyl-5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carbohydrazide); N'-benzoyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (N'-benzoyl-5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carbohydrazide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N' -Nivalyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-pivaloyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); 5-(5-(3 ,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methylbenzoyl) -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N'-(4-methylbenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); 5-(5-(3 ,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3,5-difluorobenzoyl Base)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3,5-difluorobenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carbohydrazide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N'-(4-methoxybenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methoxybenzoyl)-3-methyl-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carbohydrazide); 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-3-methyl-N'-(5-methylthiophene-2-carbonyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N'-(5- methylthiophene-2-carbonyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); N'-(2-cyclopropylacetyl)-5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro- 4H-Thieno[2,3-c]pyrrole-2-carbohydrazine (N'-(2-cyclopropylacetyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); 5-(5-(3,5-di Chloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-isobutyryl-3-methyl-5,6-dihydro -4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N'-isobutyryl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); 5-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(2-fluorobenzoyl)-3-methyl-5, 6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N'-(2-fluorobenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); 5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3,5-difluorobenzyl Acyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3,5-difluorobenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); 5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methoxy (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methoxybenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide); and 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-5,6-di Hydrogen-4H-pyrrolo[3,4-d]thiazole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-methyl-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole-2-carboxamide).

The compounds of the invention may exist as one or more stereoisomers. Various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. Those of ordinary skill in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other isomer or when it is isolated from the other isomer . Furthermore, processes or methods or techniques for separating, concentrating and/or selectively preparing said isomers are known to those having ordinary skill in the art. The compounds of the present invention may exist as a mixture of stereoisomers, as individual stereoisomers, or in optically active forms.

In cases where the compound of formula (I) is or is capable of forming a cation, the anionic portion of the salt may be inorganic or organic. Alternatively, where the compound of formula (I) is or is capable of forming an anion, the cationic portion of the salt may be inorganic or organic. Examples of the inorganic anionic portion of a salt include, but are not limited to, chloride, bromide, iodide, fluoride, sulfate, phosphate, nitrate, nitrite, bicarbonate, and bisulfate. Examples of the organic anion portion of the salt include, but are not limited to: formates, alkanoates, carbonates, acetates, trifluoroacetates, trichloroacetates, propionates, glycolates, thiocyanates, Lactate, Succinate, Malate, Citrate, Benzoate, Cinnamate, Oxalate, Alkyl Sulfate, Alkyl Sulfonate, Aryl Sulfonate, Aryl Disulphonate salt, alkyl phosphonate, aryl phosphonate, aryl diphosphonate, p-toluene sulfonate and salicylate. Examples of inorganic cationic moieties of salts include, but are not limited to, alkali metals and alkaline earth metals. Examples of organic cationic moieties of salts include, but are not limited to, pyridine, methylamine, imidazole, benzimidazole, histidine, phosphazene, tetramethylammonium, tetrabutylammonium, choline, and trimethylamine.

Metal ions in metal complexes of compounds of formula (I), especially ions of elements of the second main group (especially calcium and magnesium), ions of elements of the third and fourth main groups (especially aluminum, tin and lead) and transition groups I to VIII (especially chromium, manganese, iron, cobalt, nickel, copper, zinc, etc.). Especially preferably, metal ions of the elements of the fourth period and the first to eighth transition groups. Here, metals can be present through their various valences which can be assumed.

In one embodiment, the present invention provides a compound of formula (I), its agriculturally acceptable salts, metal complexes, structural isomers, stereoisomers, diastereomers, mirror isomers , chiral isomers, atropisomers, conformational isomers, rotational isomers, tautomers, optical isomers, polymorphs, geometric isomers or N-oxides and Composition with excipients, inert carriers or any other essential ingredients such as surfactants, additives, solid diluents and liquid diluents. The salt of the compound of formula (I) is preferably a veterinary and/or agriculturally acceptable salt, preferably an agriculturally acceptable salt. They can be formed in customary manner, eg by reacting the compound with the acid of the anion in question, if the compound of formula (I) has a basic functionality.

The term "N-oxide" includes compounds of formula (I) having at least one tertiary nitrogen atom oxidized to an N-oxide moiety.

Compounds of formula (I), including all stereoisomers, N-oxides and salts thereof, usually exist in more than one form, so formula (I) includes all crystalline and non-crystalline forms represented by compounds of formula (I) form. Amorphous forms include solid examples, such as waxes and gums, and liquid examples, such as solutions and melts. Crystalline forms include embodiments that represent substantially single crystal types as well as embodiments that represent mixtures of polymorphs (ie, different crystal types). The term "polymorph" refers to a specific crystalline form of a compound that can crystallize through different crystalline forms having different molecular arrangements and/or conformations in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due to the presence or absence of co-crystallization water or other molecules, which can be weakly or strongly bound in the crystal lattice. Polymorphs may vary in chemical, physical, and biological properties, such as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspending properties, dissolution rate, and bioavailability. Those of ordinary skill in the art will appreciate that a polymorph of a compound represented by formula (I) is relative to another polymorph or the same polymorph as a compound represented by formula (I) Mixtures of substances that may exhibit beneficial effects (e.g., suitability for the preparation of useful formulations, improved biological properties). Preparation and isolation of specific polymorphs of compounds represented by formula (I) can be achieved by methods known to those of ordinary skill in the art, including, for example, crystallization using the chosen solvent and temperature.

In one embodiment, the present invention provides a method for preparing a compound of formula (I) or an agriculturally acceptable salt thereof.

The compounds of the invention defined by formula (I) and/or table (I) can be prepared by known means in a variety of ways as described in the following schemes. The compounds of the present invention can be prepared by the schemes shown below, wherein, unless otherwise stated, the definitions of the variables are as defined above for the compounds of formula (I).

General Synthetic Procedure

Process 1 :

Compounds of formula (II) can be prepared from compounds of formula (V) according to analogous methods described in PCT Patent Publication No. WO2010020522 and as shown in Scheme 1 .

In addition, the compound of formula (IV) can be prepared by reacting the compound of formula (V) with hydroxylamine and bromine in the presence of a base such as sodium bicarbonate (NaHCO ₃ ) and a solvent such as water/dichloromethane.

The isoxazoline compound of formula (II) can be obtained by reacting the compound of formula (IV) with the styrene compound of formula (III) in the presence of base (such as sodium bicarbonate (NaHCO ₃ )) and solvent ethyl acetate. preparation.

The compound of formula (Ia) can make the bromide of formula (II) iso- Prepared by reacting an oxazole compound with a compound of formula (VI).

Process 2 :

The compound of formula (VII) (wherein, X is Br or Cl) can be formulated in the presence of a base (such as triethylamine) in a solvent (such as tetrahydrofuran) according to a similar method described in PCT Patent Publication No. WO2010151317, with the formula Amine compounds of (VII) are converted to compounds of formula (IX) by treatment.

The compound of formula (IX) (wherein, L is Br) can pass through three (dibenzylideneacetone) dipalladium (0) (tris (dibenzylideneacetone) dipalladium (0)), phosphorus ligand (phosphine ligand) CyJohnPhos, In the presence of a base (such as sodium tert-butoxide), it is treated with an amine compound of formula (XII) to convert it into a compound of formula (XIII) (refer to PCT Patent Publication No. WO2018095260).

The compound of formula (IX) (wherein, L is Br) can be prepared according to the similar method described in PCT Patent Publication No. WO2018137644, through the atmosphere of carbon monoxide, with 1,3-bis(diphenylphosphino)propane (1, 3-bis (diphenylphosphino) propane), palladium acetate (palladium acetate), triethylamine treatment and converted into formula (X) compound.

Compounds of formula (XIX) can be prepared from compounds of formula (X) by deprotection of various protecting groups as described in PCT Patent Publication No. WO2008044027 and PCT Patent Publication No. WO2019015559.

The compound of formula (XV) can be prepared by hydrolyzing the compound of formula (X) in the presence of NaOH aqueous solution and tetrahydrofuran/methanol solvent.

The compound of formula (XI) can be passed through a suitable solvent (such as tetrahydrofuran) and at 0 ℃, make the compound of formula (X) or formula (XV) and reducing agent (for example lithium aluminum hydride (lithium aluminum hydride) or borane tetrahydrofuran aluminum Compound solution (borane tetrahydrofuran complex solution)) reaction prepared.

The compound of formula (XVII) (where LG is Br) can be prepared from the compound of formula (XI) in the presence of a brominating agent (such as phosphorus tribromide, tetrabromomethane) and triphenylphosphine in dichloromethane. Compounds of formula (XVII) (where LG is OMs) can be permeated through methanesulfonyl chloride, N , N -dimethylamino Prepared by reacting the compound of formula (XI) in the presence of pyridine ( N , N -dimethylamino pyridine) and triethylamine.

Compounds of formula (XIV), formula (XVI) and formula (XVIII) can be prepared by deprotection of protecting groups according to methods similar to those shown in step 10 of scheme 2.

Process 3 :

The compound of formula (IX) (wherein, L is Br) can be obtained by the presence of a coupling agent (such as palladium or copper catalyst) as described in PCT patent publication number WO2006082001, PCT patent publication number WO2017031918 or PCT patent publication number WO2019144969. , in the presence or absence of a ligand, in the presence of a base such as sodium tert-butoxide or N,N-dimethylformamide ( N , N dimethylformamide), treated with a compound of formula (XX) And converted to formula (XXI) compound.

Compounds of formula (XXII) can be prepared by deprotection of individual protecting groups according to similar methods as shown in step 10 of Scheme 2.

Process 4 :

Compounds of formula (XXIV) and formula (XXIII) can be prepared by reacting bromoisoxazole compounds of formula (II) with compounds of formula (XVIII) and formula (XIV) respectively according to a similar method as shown in step 3 of scheme 1 Prepared.

Compounds of formula (XXVb- d ) (wherein, LG is OMs, Br ) can be dissolved in a base (such as cesium carbonate (CS ₂ CO ₃ ) or potassium carbonate (K ₂ CO ₃ )), by treating the compound of formula (XIV) with -NR ⁵ R ⁶ , -OR ⁴ and -SR ⁴ .

Process 5 :

Compounds of formula (XXVI) can be prepared by reacting bromoisoxazole compounds of formula (II) with compounds of formula (XIX) according to a similar method as shown in step 3 of Scheme 1 .

The compound of formula (XXVII) can be prepared by hydrolyzing the compound of formula (XXVI) in the presence of NaOH aqueous solution and THF/methanol solvent.

The compound of formula (XVIII) is permeable to a coupling agent (such as 1-[bis(dimethylamino)methylene]-1H-1 in a solvent (such as N , N -dimethylformamide (DMF)). ,2,3-Triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5- b] in the presence of pyridinium 3-oxide hexafluorophosphate, HATU)) and a base (such as N , N -diisopropylethylamine (DIPEA)), the acidic compound of formula (XVII) and the amine compound of formula (XII) are reacted Prepared.

Depending on the nature of the substituents, the compounds of the formula (I) and their intermediates can exist in pure form or as different possible isomeric forms (eg stereoisomers or structural isomers). Various stereoisomers include enantiomers, diastereomers, chiral isomers, atropisomers, conformational isomers, rotamers, tautomers, optical isomers, Homogeneous polymorphs and geometric isomers.

According to the nature of the substituent, the formula (I) compound and its intermediate product mentioned in the general scheme can also exist in the form of one or more geometric isomers, depending on the relative position of the substituent (cis/trans (syn /anti) or cis/trans (cis/trans)). The present invention therefore equally relates to all cis/trans (syn/anti) (or cis/trans (cis/trans)) isomers and all possible cis/trans (syn/anti) (or cis/trans (cis/trans) mixture. The cis/trans (syn/anti) (or cis/trans) isomers can be separated according to usual methods known per se to those having ordinary skill in the art to which this application pertains.

In another embodiment, the present invention provides a method of preparing a compound of formula (I) or a salt thereof.

Compounds of formula (I) including their stereoisomers, salts and N-oxides and their precursors during synthesis can be prepared by the above methods. If individual compounds cannot be prepared via the above-mentioned routes, they can be prepared via other compounds derived from formula (I) or the respective precursors, or via conventional modifications of the synthetic routes described. For example, in individual cases certain compounds of formula (I) can advantageously be prepared by derivatizing other compounds of formula (I), for example by ester hydrolysis, amidation, esterification, ether cleavage, olefination, reduction, Oxidation, etc., or through routine modification of the synthetic route.

The reaction mixture is worked up in a customary manner, for example by mixing with water, separation of the phases and, if appropriate, chromatographic purification of the crude product. Some intermediates and final products were obtained as colorless or light colored viscous oils which were purified or freed of volatile components under reduced pressure and moderately elevated temperature. If intermediate and final products are obtained in solid form, they can also be purified by recrystallization or digestion.

If compound (I) alone cannot be prepared by the above-mentioned routes, it can be prepared by other compounds derived from formula (I). However, if the individual syntheses result in a mixture of isomers, separation is generally not required, since in some cases the individual isomers may be lost during work-up for use or during application (e.g. in the presence of light, free-radical generation, under the action of agents, acids or bases) for interconversion. This transformation can also take place after use, for example during phytotreatment in the treated plant, or in the harmful pest to be controlled.

In one embodiment, the present invention provides a composition for controlling or preventing invertebrate pests. The above-mentioned composition comprises a biologically effective amount of the compound of formula (I), its agriculturally acceptable salt, stereoisomer, diastereomer, mirror-image isomer, tautomer, metal complex , polymorphs or N-oxides, and at least one additional component selected from the group consisting of surfactants and auxiliary agents.

In another embodiment, the above composition further comprises at least one additional bioactive compatible compound selected from the group consisting of fungicides, insecticides, nematocides, acaricides, biopesticides, herbicides agents, plant growth regulators, antibiotics, fertilizers or nutrients.

In yet another embodiment, the present invention provides a compound of formula (I) or its N-oxide and salt can be converted into conventional types of agricultural chemical composition, such as: solution, emulsion, suspension, powder, powder, paste , granules, compressed preparations, capsules and mixtures thereof. Examples of composition types are suspensions (e.g. SC, OD, FS), emulsifiable concentrates (e.g. EC), emulsions (e.g. EW, EO, ES, ME), capsules (e.g. CS, ZC), pastes, lozenges, Wet powders or powders (such as WP, SP, WS, DP, DS), compressed preparations (such as BR, TB, DT), granules (such as WG, SG, GR, FG, GG, MG), insecticidal preparations ( eg LN) and gel formulations for the treatment of plant propagation material such as seeds (eg GF). These and other composition types are defined in "Catalogue of pesticide Formulation types and international coding system", Technical Monograph No. 2, 6 ^th Ed. May 2008, CropLife International".

The above compositions are prepared in a known manner, as described, for example, in Mollet and Grubemann, "Formulation technology, Wiley VCH, Weinheim, 2001"; or, in Knowles, "New developments in crop protection product Formulation, Agrow Reports DS243, T&F Informa, London, 2005” as described.

Examples of suitable auxiliaries are solvents, liquid carriers, solid carriers or extenders, surfactants, dispersants, emulsifiers, wetting agents, auxiliary agents, solubilizers, penetration enhancers, protective colloids, binders, thickeners Agents, moisturizers, insect repellents, attractants, feeding stimulants, expanders, fungicides, antifreeze agents, defoamers, colorants, thickeners and adhesives.

Suitable solvents and liquid carriers are water and organic solvents such as medium to high boiling mineral oil fractions such as kerosene, diesel oil; vegetable or animal oils; aliphatic, cyclic and aromatic hydrocarbons such as toluene, paraffin, tetralin, Alkylated naphthalene compounds; alcohols such as ethanol, propanol, butanol, benzyl alcohol, cyclohexanol; ethylene glycol; dimethylsulfoxide; ketones such as cyclohexanone; esters such as lactate , carbonates, fatty acid esters, gamma-butyrolactone; fatty acids; phosphates; amines; amides such as N-methylpyrrolidone, fatty acid dimethylamide; and mixtures thereof.

Suitable solid carriers or fillers are mineral earths such as silicates, silica gel, talc, kaolin, limestone, lime, chalk, clay, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide; polysaccharides, For example cellulose, starch; fertilizers such as ammonium sulphate, ammonium phosphate, ammonium nitrate, urea; products of plant origin such as cereal flour, bark flour, wood flour, nut shell flour and mixtures thereof.

Suitable surfactants are surface-active compounds such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes and mixtures thereof. Such surfactants can be used as emulsifiers, dispersants, solubilizers, wetting agents, penetration enhancers, protective colloids or adjuvants. Examples of surfactants are listed in “McCutcheon’s, Vol. 1: Emulsifiers & Detergents, McCutcheon’s Directories, Glen Rock, USA, 2008 (International or North American version)”.

Suitable anionic surfactants are alkali metal, alkaline earth metal or ammonium salts of sulfonates, sulfates, phosphates, carboxylates and mixtures thereof. Examples of sulfonates are alkylarylsulfonates, diphenylsulfonates, alpha-olefinsulfonates, lignosulfonates, sulfonates of fatty acids and oils, ethoxylated alkylphenols Sulfonates of sulfonates, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalene, sulfonates of decyl and tridecylbenzene, sulfonates of naphthalene and alkylnaphthalene, sulfonates sulfosuccinate or sulfosuccinamate. Examples of sulfates are the sulfates of fatty acids and oils, the sulfates of ethoxylated alkylphenols, the sulfates of alcohols, the sulfates of ethoxylated alcohols or the sulfates of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates and carboxylated alcohol or alkylphenol ethoxylates.

Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants and mixtures thereof. Examples of alkoxylates are compounds which have been alkoxylated with 1 to 50 equivalents, such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters. Ethylene oxide and/or propylene oxide can be used for the alkoxylation reaction, preferably ethylene oxide. Examples of N-substituted fatty acid amides are fatty acid glucosamides or fatty acid alkanolamides. Examples of esters are fatty acid esters, glycerides or monoglycerides. Examples of sugar-based surfactants are sorbitan, ethoxylated sorbitan, sucrose and glucose esters or alkyl polyglycosides. Examples of polymeric surfactants are homopolymers or copolymers of vinylpyrrolidone, vinyl alcohol or vinyl acetate.

Suitable cationic surfactants are quaternary surfactants, such as quaternary ammonium compounds with one or two hydrophobic groups, or salts of long chain primary amines. Suitable amphoteric surfactants are alkyl betaines and imidazolines. Suitable block polymers are block polymers of type A-B or A-B-A comprising polyethylene oxide and polypropylene oxide blocks, or type A-B-C comprising alkanols, polyethylene oxide and polypropylene oxide block polymers. Suitable polyelectrolytes are polyacids or bases. Examples of polyacids are alkali metal salts of polyacrylic acid or polyacid comb polymers. Examples of polybasic bases are polyvinyl amines or polyethylene amines.

Suitable adjuvants are compounds which themselves have negligible or even no pesticidal activity, which improve the biological performance of the compounds of formula (I) on the target. Examples of adjuvants are surfactants, mineral or vegetable oils and other auxiliaries. Further examples are set out in "Knowles, Adjuvants and added, Agrow Reports DS256, T&F Informa UK, 2006, Chapter 5".

Suitable thickeners are polysaccharides (eg Sanxian gum, carboxymethylcellulose), inorganic clays (organically modified or not), polycarboxylates and silicates. Suitable fungicides are bronopol and isothiazolinone derivatives, such as alkylisothiazolinones and benzisothiazolinones. Suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin. Suitable defoamers are silicones, long-chain alcohols and salts of fatty acids. Suitable colorants such as red, blue or green are low water soluble pigments and water soluble dyes. Examples are inorganic colorants (such as iron oxide, titanium oxide, iron hexanitrile) and organic colorants (such as alizarin, azo and phthalocyanine colorants). Suitable tackifiers or adhesives are polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, polyacrylates, biological or synthetic waxes and cellulose ethers.

The types of compositions and their preparation methods are as follows:

i) Water-soluble concentrates (SL, LS) 10-60 wt% of the compound of formula (I) (or its N-oxide or salt) and 5-15 wt% of wetting agent (such as alcohol alkoxylate) are dissolved in water added to 100 wt% and/ Or water-soluble solvents (such as alcohols). The active substance dissolves on dilution with water.

ii) Dispersible Concentrate (DC) 5-25 wt% of a compound of formula (I) (or its N-oxide or salt) and 1-10 wt% of a dispersant (such as polyvinylpyrrolidone) are dissolved in an organic solvent added to 100 wt% (such as ring Hexanone). Dilution with water gives a dispersion.

iii) Emulsifiable Concentrates (EC) 15-70 wt% of the compound of formula (I) (or its N-oxide or salt) and 5-10 wt% of emulsifiers (such as calcium dodecylbenzenesulfonate and ethoxylated castor oil) are dissolved In water-insoluble organic solvents (such as aromatic hydrocarbons) added to 100 wt%. Dilution with water gives an emulsifier.

iv) Emulsions (EW, EO, ES) 5-40 wt% of the compound of formula (I) (or its N-oxide or salt) and 1-10 wt% of emulsifiers (such as calcium dodecylbenzenesulfonate and ethoxylated castor oil) are dissolved In 20-40 wt% of water-insoluble organic solvents (such as aromatic hydrocarbons). Then, by using an emulsifier, the mixture was added to water up to 100 wt% to make it a uniform emulsion. Dilute with water to obtain an emulsion.

v) Suspensions (SC, OD, FS) Add 2-10 wt% of dispersant and wetting agent (such as sodium lignosulfonate and alcohol ethoxylate) to 20-60 wt% of the compound of formula (I) (or its N-oxide or salt) , 0.1-2 wt% thickener (such as Sanxian gum) and water added to 100 wt% are pulverized in a stirring ball mill to obtain a good active substance suspension. Dilution with water gives a stable suspension of the active substance. For FS-type compositions, add up to 40 wt% of binder (such as polyvinyl alcohol).

vi) Water Dispersible Granules and Water Soluble Granules (WG, SG) Add 50-80 wt% of the compound of formula (I) (or its N-oxide or salt) to 100 wt% of dispersant and wetting agent (such as sodium lignosulfonate and alcohol ethoxylate) Finely ground and prepared as water-dispersible or water-soluble granules by technical equipment (eg extrusion, spray tower, fluidized bed). Dilution with water gives a stable dispersion or solution of the active substance.

vii) Water Dispersible Powder and Water Soluble Powder (WP, SP, WS) 50-80 wt% of the compound of formula (I) (or its N-oxide or salt) is added with 1-5 wt% of dispersant (such as sodium lignosulfonate), 1-3 wt% of wetting agent (e.g. alcohol ethoxylate) and up to 100 wt% solid carrier (e.g. silica gel) in a rotor-stator mill. Dilution with water gives a stable dispersion or solution of the active substance.

viii) Gels (GW, GF) Add 3-10 wt% of dispersant (such as sodium lignosulfonate) and 1-5 wt% of thickener to 5-25 wt% of the compound of formula (I) (or its N-oxide or salt) (e.g. carboxymethyl cellulose) and water up to 100% by weight are pulverized in an agitating ball mill to obtain a good active substance suspension. Dilution with water gives a stable suspension of the active substance.

ix) Microemulsions (ME) 5-20 wt% of the compound of formula (I) (or its N-oxide or salt) is added to 5-30 wt% of the organic solvent mixture (such as fatty acid dimethylamide and cyclohexanone), 10-25 Surfactant mixture (eg alcohol ethoxylates and arylphenol ethoxylates) in wt % and water up to 100 % wt. The mixture was stirred for one hour to spontaneously generate a thermodynamically stable microemulsion.

x) Microcapsules (CS) Including 5-50 wt% of the compound of formula (I) (or its N-oxide or salt), 0-40 wt% of water-insoluble organic solvent (such as aromatic hydrocarbon) and 2-15 wt% of acrylic acid monomer (e.g. methyl methacrylate, methacrylic acid and di- or triacrylates) are dispersed into an aqueous solution of protective colloids (e.g. polyvinyl alcohol). Free radical polymerization leads to the formation of poly(meth)acrylate microcapsules. Alternatively, 5-50 wt% of the compound of formula (I) of the present invention, 0-40 wt% of water-insoluble organic solvents (such as aromatic hydrocarbons) and isocyanate monomers (such as diphenylene methyl-4,4'-diisocyanate) is dispersed into an aqueous solution of a protective colloid (e.g. polyvinyl alcohol). Addition of polyamines such as hexamethylenediamine leads to the formation of polyurea microcapsules. The amount of monomer is 1-10 wt%. Its weight percent is relative to the total CS composition.

xi) Dustable powders (DP, DS) 1-10 wt% of a compound of formula (I) (or N-oxide or salt thereof) is finely ground and intimately mixed with up to 100 wt% of a solid carrier such as finely divided kaolin.

xii) Particles (GR, FG) 0.5-30 wt% of a compound of formula (I) (or N-oxide or salt thereof) is finely ground and combined with a solid carrier (eg silicate) added to 100 wt%. Granulation is achieved by extrusion, spray drying or fluidized bed.

xiii) Ultra Low Volume Liquid (UL) 1-50 wt% of the compound of formula (I) (or N-oxide or salt thereof) is dissolved in an organic solvent (such as an aromatic hydrocarbon) added to 100 wt%.

Composition types i) to xiii) can optionally include further additives, such as 0.1-1 wt% bactericide, 5-15 wt% antifreeze, 0.1-1 wt% defoamer and 0.1-1 wt% 1 wt% coloring agent.

In another embodiment, the present invention provides an agricultural chemical composition comprising a compound of formula (I), which comprises 0.01-95% by weight, preferably 0.1-90%, more preferably 0.1-70 %, especially 10-60% active ingredients. The active ingredient is used in a purity (according to NMR spectrum) of 90% to 100%, preferably 95% to 100%.

For the treatment of plant propagation material, especially seeds, solutions (LS), suspoemulsions (SE), flowable concentrates (FS), powders for dry treatment ( DS), water dispersible powders (WS), water soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC) and gels (GF) for slurry processing. The composition has an active substance concentration of 0.01 to 60%, preferably 0.1 to 40%, by weight in the ready-to-use preparation after two to ten-fold dilution. Application can be done before or during sowing.

A method for applying the compound of formula (I) and its composition to plant propagation materials (especially seeds) respectively, which includes: dressing (dressing), coating (coating), granulating, dusting, soaking (soaking) and in-furrow application methods. Preferably, the compound of formula (I) or its composition is applied to the plant propagation material by methods that do not induce germination (for example, by seed dressing, granulation, coating and dusting).

When used for plant protection, the amount of active substance applied is, depending on the type of effect desired, from 0.001 to 2 kg per hectare, preferably from 0.005 to 2 kg per hectare, more preferably from 0.02 to 0.9 kg per hectare, Specifically 0.05 to 0.75 kg per hectare.

When treating plant propagation material such as seeds, e.g. by dusting, coating or drenching the seeds, 0.1 to 1000 g, preferably 1 to 1000 kg of plant propagation material, preferably seeds 1000 grams, more preferably 1 to 100 grams, and more preferably 5 to 100 grams of active ingredient is usually required.

When used to protect materials or store products, the amount of active substance used depends on the type of application and the desired effect. Usually the amount used for material protection is 0.001 g to 2 kg, preferably 0.005 g to 1 kg active substance/m3 of treated material.

Different types of oils, wetting agents, adjuvants, fertilizers or micronutrients and other insecticides (e.g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides) can be used as The premix is added to the active substance or composition containing the active substance, or, if appropriate, until just before use (tank mix). These agents may be mixed with the composition according to the present invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.

Users typically apply the compositions of the invention from a pre-dose device, knapsack sprayer, spray can, aircraft spray or irrigation system. Usually, the agrochemical composition is made of water, buffer and/or other auxiliaries to make the required application concentration, so as to obtain the ready-to-use spray liquid or the agrochemical composition of the present invention. Usually, 20 to 6000 liters, preferably 35 to 1000 liters, more preferably 50 to 500 liters of the ready-to-use spray liquid are applied per hectare of agriculturally useful area.

According to one embodiment, the individual components of the composition according to the invention, for example part of a kit or part of a binary or ternary mixture, can be mixed, if appropriate, by the user himself in a spray tank or other auxiliary equipment.

The compounds and compositions of the present invention are therefore useful agronomically for the protection of field crops from phytophagous invertebrate pests and non-agronomically for the protection of other horticultural crops and plants from phytophagous invertebrate pests. infringement. This application includes the protection of crops and other plants (ie agronomic and non-agronomic) that contain genetic material introduced through genetic engineering (ie gene transfer) or modified through mutagenesis to provide advantageous traits.

The compounds of the invention are characterized by good metabolism and/or soil residual patterns and exhibit activity in controlling a range of agronomic and non-agronomic invertebrate pests.

The compounds of the present invention are active ingredients with preventive and/or treatment value in the field of pest control, and can be used to control insecticide-resistant pests such as insects and mites even at low application rates, and are harmful to warm-blooded animals, fish and plants. It is well tolerated.

In the context of this specification, "invertebrate pest control" means inhibition of invertebrate pest development (including mortality) which results in a significant reduction in feeding or other injury or damage by the pest; related terms are similarly defined. As stated in the present specification, the term "invertebrate pest" includes economically important pests such as arthropods, gastropods and nematodes. The term "arthropod" includes insects, mites, spiders, scorpions, centipedes, millipedes, bulb bugs and myriapods.

The term "gastropod" includes snails, slugs and other stalks. The term "nematode" includes all worms such as roundworms, heartworms, herbivorous nematodes (Nematoda), trematodes (Tematoda), acanthocephala and tapeworms (Cestoda). Those of ordinary skill in the art will recognize that not all compounds are equally effective against all pests.

The compounds of the present invention show activity against economically important pests of agronomic, forest, greenhouse, nursery, ornamental, turfgrass, food and fiber, public and animal health, household and commercial structures, household and stored products. These pests include larvae of the order Lepidoptera, such as armyworms, cutworms, loopers, and heliothines (e.g., fall armyworm, Spodoptera fugiperda J. E. Smith), beet armyworm (beet armyworm, Spodoptera exigua Hubner), cabbage armyworm (black cutworm, Agrotis ipsilon Hufnagel), cabbage looper ( Trichoplusia ni Hubner), tobacco armyworm (tobacco budworm , Heliothis virescens Fabricius)); from borer, casebearer, webworm, coneworm, cabbageworm and roll Skeletonizers (for example, European corn borer ( Ostrinia nubilalis Hubner), navel orangeworm ( Amyelois transitella Walker), corn root webworm ( Crambus caliginosellus Clemens), grass bugs (sod worm, Herpetogrammalicarsisalis Walker); leafrollers, budworms, seed worms and fruit worms of the family Tortricidae (for example, codling moth , Cydia pomonella Linnaeus), grape berry moth ( Endopiza viteana Clemens), oriental fruit moth (Oriental fruit moth, Grapholita molesta Busck)); and many other economically important Lepidoptera (e.g. diamondback moth (diamondback moth, Plutella xylostella Linnaeus), pink bollworm (pink bollworm, Pectinophora gossypiella Saunders), gypsy moth ( Lymantria dispar Linnaeus)); nymphs (nymphs) and adults of the order Blattodea, including source From Blattellidae and cockroaches of the family Blattidae (e.g., oriental cockroach, Blatta orientalis Linnaeus), Asian cockroach ( Blatella asahinai Mizukubo), German cockroach (German cockroach, Blattella germanica Linnaeus), brownbanded cockroach (brownbanded cockroach, Supella longipalpa Fabricius), American cockroach (American cockroach, Periplaneta Americana Linnaeus), brown cockroach (brown cockroach, Periplaneta brunnea Burmeister), Madeira cockroach cockroach (Madeira cockroach, Leucophaea maderae Fabricius)); leaf-eating larvae and adults of the order Coleoptera, which includes species from the families Anthribidae, Bruchidae and Curculionidae. Weevil (e.g., boll weevil, Anthonomus grandis Boheman, rice water weevil, Lissorhoptrus oryzophilus Kuschel), grain weevil ( Sitophilus granaries Linnaeus), rice weevil , Sitophilus oryzae Linnaeus)); flea beetle, cucumber beetle, rootworm, leaf beetle, potato beetle and leafminers (e.g., Colorado potato beetle, Leptinotarsa decemlineara Say, western corn rootworm, Diabrotica virgifera virgifera LeConte); chafers from the Scaribaeidae family and other beetles (e.g., Japanese beetle, Popillia japonica Newman and European chafer, Rhizotrogus majalis Razoumowsky); from the carpet beetle of the family Dermestidae; from the carpet beetle wireworm from the family Elateridae; bark beetles from the family Scolytidae and flour beetles from the family Tenebrionidae. In addition, it includes: adults and larvae of the order Dermaptera, including earwigs from the family Forficulidae (e.g., European earwig, Forficula auricularia Linnaeus), black ground Centipedes (black earwig, Chelisoches morio Fabricius); adults and nymphs of the orders Hemiptera and Homoptera, such as plant bugs from the Miridae family, plant bugs from the cicada ( Cicadas from the family Cicadidae, leafhoppers from the family Cicadellidae (e.g. Empoasca spp.), from the family Fulgoroidae and from planthoppers (Delphacidae) Planthopper (planthopper) from family Psyllidae, psyllid from family Psyllidae, whitefly from family Aleyrodidae, aphid from family Aphididae , from phylloxera in the family Phylloxeridae, mealybug from the family Pseudococcidae, from the families Coccidae, Diaspididae and Margarodidae ) from the family Scale, from the lace bug from the Tingidae family, from the stink bug from the Pentatomidae family, from the stink bug from the Lygaeidae family Chinch bugs (for example, Blissus spp. ) and other seed bugs, spittlebugs from the family Cercopidae, spittlebugs from the family Cercopidae, Coreidae ) of the squash bug (squash bug) and the red bug (red bug) and cotton stainer (cotton stainer) derived from the star stinkbug (Pyrrhocoridae) family. Also includes adults and larvae of the order Acari (mite), such as spider mite and red mite of the family Tetranychidae (e.g., European red mite, Panonychus ulmi Koch), two spotted spider mite, Tetranychus urticae Koch, McDaniel mite, Tetranychus mcdanieli McGregor), flat mite of the family Tenuipalpidae (e.g., citrus short beard mite (citrus flat mite, Brevipalpus lewisi McGregor), rust mite and bud mite of the family Eriophyidae and other spider mites and mites important to the state of human and animal health, That is, dust mite of Epidermoptidae family, follicle mite of Demodicidae family, grain mite of Glycyphagidae family, hard tick ( Ticks of the family Ixodidae) (e.g., deer tick ( Ixodes scapularis Say), Australian paralysis tick ( Ixodes holocyclus Neumann), American dog tick ( Dermacentor variabilis Say), Star tick (lone star tick, Amblyomma americanum Linnaeus) and scab mite (scab mite, itch mite) of the families Psoroptidae, Pyemotidae and Sarcoptidae; Adults and larvae, which include grasshoppers, locusts, and crickets (e.g., migratory grasshoppers (e.g., Melanoplus sanguinipes Fabricius, M. differentialis Thomas) ), American grasshopper (for example, Schistocerca Americana Drury), desert locust (desert locust, Schistocerca gregaria Forskal), migratory locust (Locusta migratoria Linnaeus), house cricket (house cricket, Acheta domesticus Linnaeus ), mole cricket (mole cricket, Gryllotalpa spp. )); adults and larvae of Diptera (Diptera), which includes leafminer (leafminer), midge (midge), fruit fly (Tephritidae (Tephritidae) ), frit flies (e.g. Oscinella frit Linnaeus), soil maggots, house flies (e.g. Musca domestica Linnaeus), smaller Lesser house flies (eg, Fannia canicularis Linnaeus, F. femoralis Stein), stable flies (eg, Stomoxys calcitra ns Linnaeus) , face fly, horn fly, blow fly ( eg, Chi ysomya spp. , Phormia spp. ), and others Fly pests, horse flies (e.g. Tabanus spp. ), bot flies (e.g. Gastrophilus spp. , Oestrus spp. ) , cattle grub (e.g. Hypoderma spp. ), deer fly (e.g. Ch hrysops spp. ), ked (e.g. sheep lice flies ( Melophagus ovinus Linnaeus)) and other Brachycera suborders (Brachycera), mosquitoes (mosquitoes) (eg, Aedes spp. , Anopheles spp. ), Culex spp. ), black fly (e.g. Prosimulium spp. , Simulium spp. ), biting midge, sand fly, sciarid and Other Nematocera; adults and larvae of Thysanoptera, including onion thrips, Thrips tabaci Lindeman and other leaf-eating thrips; including membranes of ants of the family Formicidae Pests of the order Hymenoptera, such ants are red carpenter ant ( Camponotus ferrugineus Fabricius), black carpenter ant ( Camponotus pennsylvanicus De Geer), small yellow house ants (Pharaoh ant, Monomorium pharaonis Linnaeus), little fire ant, Wasmannia auropunctata Roger, fire ant, Solenopsis geminate Fabricius, red imported fire ant, Solenopsis invicta Buren, Argentine ant, Iridomyrmex humilis Mayr), crazy ant, Paratrechina longicornis Latreille, pavement ant, Tetramorium caespitum Linnaeus, cornfield ant, Lasius alienus Frster, and odorous house ant, Tapinoma sessile Say ; Honeybees (including carpenter bee), hornets, yellow jackets and wasps; pests of the order Isoptera, which include eastern subterranean termites, Reticulitermes flavipes Kollar), western subterranean termite (western subterranean termite, Reticulitermes hesperus Banks), Taiwan milk termite (Formosan subterranean termite, Coptotermes formosanus Shiraki), West Indian drywood termite (West Indian drywood termite, Incisitermes immigrans Snyder) and other economically Important termites; pests of the order Thysanura, such as silverfish, Lepisma saccharina Linnaeus and firebrat, Thermobia domestica Packard; pests of the order Mallophaga, and including head louse , Pediculus humanus capitis De Geer), body louse, Pediculus humanus Linnaeus, chicken body louse, Menacanthus stramineus Nitszch, dog biting louse, Trichodectes canis De Geer, fluff louse, Goniocotes gallinae De Geer), sheep body louse (sheep body louse, Bovicola ovis Schrank), short-nosed cattle louse, Haematopinus eurysternus Nitzsch, long-nosed cattle louse, Linognathus vituli Linnaeus) and other sucking and chewing parasitic lice that attack humans and animals; pests of the order Siphonoptera, including oriental rat flea, Xenopsylla cheopis Rothschild, cat flea, Ctenocephalides felis Bouche), dog flea (dog flea, Ctenocephalides canis Curtis), chicken flea (hen flea, Ceratophyllus gallinae Schrank), sticktight flea (sticktight flea, Echidnophaga gallinacea Westwood), human flea ( Pulex irritans Linnaeus) and Other fleas that afflict mammals and birds. Other arthropod pests covered include: spiders of the order Araneae such as brown recluse spiders (brown recluse spiders, Loxosceles reclusa Gertsch and Mulaik) and black widow spiders (black widow spiders ( Latrodectus mactans Fabricius) and gnatflies ( Scutigeromorpha), for example the common house centipede ( Scutigera coleoptrata Linnaeus). It is also effective against members of the class Nematodes, Taenia, Trematodes and Acanthocephala, members of which include Strongylida, Ascaridida, Oxyurida, Rhabditida, Economically important members of the orders Spirurida and Enoplida, such as, but not limited to, economically important agricultural pests (i.e. root knot nematodes of the genus Meloidogyne ) ), root rot nematodes (lesion nematodes of the genus Pratylenchus, stubby root nematodes of the genus Trichodorus, etc.) flukes, tapeworms and roundworms, such as Strongylus vulgaris in horses, Toxocara canis in dogs, Haemonchus contortus in sheep, Dirofilaria immitis in dogs Leidy), Anoplocephala perfoliata in horses, Fasciola hepatica Linnaeus in ruminants, etc.).

The compounds of the present invention exhibit particularly high activity against pests of the order Lepidoptera, such as Alabama argillacea Hbner, cotton leaf worm, Archips argyrospila Walker, fruit tree leaf worm roller), European leaf roller ( A. rosana Linnaeus, European leaf roller) and other roller moth species ( Archips species ), rice stem borer ( Chilo suppressalis Walker, rice stem borer), rice leaf roller ( Cnaphalocrosis medinalis Guenee , rice leaf roller), corn root web caterpillar ( Crambus caginosellus Clemens, corn root webworm), berry grass net caterpillar ( Crambus teterrellus Zincken, bluegrass webworm), codling moth ( Cydia pomonella Linnaeus, codling moth), Egyptian diamond ( Earias insulana Boisduval, spiny bollworm), spotted bollworm ( Earias vittella Fabricius, spotted bollworm), American bollworm ( Helicoveipa armigera Hύbner, American bollworm), corn earworm ( Helicoverpa zea Boddie, corn earworm), tobacco armyworm ( Heliothis virescens Fabricius , tobaccoco budworm), grass netting caterpillar ( Herpetogramma licarsisalis Walker, sod webworm), grape berry moth ( Lobesia botrana Denis and Schiffeπnύller, grape berry moth), red bollworm ( Pectinophora gossypiella Saunders, pink bollworm), citrus leaf miner Moth ( Phyllocnistis citrella Stainton, citrus leafminer), large white butterfly ( Pieris brassicae Linnaeus, large white butterfly), small white butterfly ( Pieris rapae Linnaeus, small white butterfly), diamondback moth ( Plutella xylostella Linnaeus, diamondback moth), beet armyworm ( S podoptera exigua Hubner, beet armyworm), cutworm ( Spodoptera litura Fabricius, tobacco cutworm, cluster caterpillar), fall armyworm ( Spodoptera frugiperda J.E. Smith, fall armyworm), cabbage looper ( Trichoplusia ni Hύbner, cabbage looper) and tomato spot Miner flies ( Tuta absoluta Meyrick, tomato leafminer).

The compounds of the present invention also have commercially significant activity against members of the order Homoptera, including: Acyrthosiphon pisum Harris (pea aphid), cowpea aphid ( Aphis craccivora Koch, cowpea aphid), black bean aphid ( Aphis fabae Scopoli, black bean aphid), cotton aphid ( Aphis gossypii Glover, cotton aphid, melon aphid), apple aphid ( Aphis pomi De Geer, apple aphid), rust spiral aphid ( Aphis spiraecola Patch, spirea aphid), potato aphid ( Aulacorthum solani Kaltenbach, foxglove aphid), strawberry aphid ( Chaetosiphon fragaefolii Cockerell, strawberry aphid), Russian wheat aphid ( Diuraphis noxia Kurdjumov/Mordvilko, Russian wheat aphid), rose apple aphid ( Dysaphis plantaginea Paaserini, rosy apple aphid), apple aphid ( Eriosoma lanigerum Hausmann, woolly apple aphid), peach aphid ( Hyalopterus pruni Geoffroy, mealy plum aphid), turnip aphid ( Lipaphis erysimi Kaltenbach, turnip aphid), wheat aphid ( Metopolophium dirrhodum Walker, cereal aphid), Macrosiphum euphorbiae Thomas, potato aphid, Myzus persicae Sulzer, peach-potato aphid, green peach aphid, Nasonovia ribisnigri Mosley, lettuce aphid, Pemphigus spp. ) (root aphid and gall aphid), corn leaf aphid ( Rhopalosiphum maidis Fitch, corn leaf aphid), grain aphid ( Rhopalosiphum padi Linnaeus, bird cherry-oat aphid), wheat bifurcation Aphids ( Schizaphis graminum Rondani, greenbug), Sitobion avenae Fabricius, English grain aphid, Therioaphis maculate Buckton, spotted alfalfa aphid, Toxoptera aurantii , Boyer de Fonscolombe, black citrus aphid) and brown citrus aphid ( Toxoptera citricida Kirkaldy, brown citrus aphid); Adelges spp. (adelgid); American hickory phylloxera ( Phylloxera devastatrix Pergande, pecan phylloxera); tobacco whitefly ( Bemisia tabaci Gennadius, tobaccoco whitefly, sweetpotato whitefly), silverleaf whitefly ( Bemisia argentifolii Bellows and Perring, silverleaf whitefly), citrus whitefly ( Dialeurodes citri Ashmead, citrus whitefly) and greenhouse whitefly ( Trialeurodes vaporariorum West wood, greenhouse whitefly) ; Potato leafhopper ( Empoasca fabae Harris, potato leafhopper), small brown planthopper ( Laodelphax striatellus Fallen, smaller brown planthopper), purple leafhopper ( Macrolestes quadrilineatus Forbes, aster leafhopper), green leafhopper ( Nephotettix cinticeps Uhler, green leafhop per) , Nephotettix nigropictus Stal, rice leafhopper), Brown ricehopper ( Nilaparvata lugens Stal, brown planthopper), Corn planthopper ( Peregrinus maidis Ashmead, corn planthopper), White-backed planthopper ( Sogatella furcifera Horvath, white-backed planthopper) , rice planthopper ( Sogatodes orizicola Muir, rice delphacid), apple white leafhopper ( Typhlocyba pomaria McAfee, white apple leafhopper), grape leafhopper ( Erythroneoura spp. ) (grape leafhopper (grape leafhopper)); periodical cicada ( Magicidada septendecim Linnaeus, periodic cicada); Icerya purchase Maskell (cottony cushion scale), Quadraspidiotus perniciosus Comstock (San Jose scale); Citrus mealybug ( Planococcus citri Risso, citrus mealybug); ( Pseudococcus spp. ) (other mealybug complexes); pear psyllid ( Cacopsylla pyricola Foerster, pear psylla), persimmon psyllid ( Trioza diospyri Ashmead, persimmon psylla).

The compounds of the present invention may also be active against members of the order Hemiptera, including: Acrosternum hilare Say, green stink bug, Anasa tristis De Geer, squash bug, Squash bug Blissus leucopterus leucopterus Say, chinch bug, Corythuca gossypii Fabricius, cotton lace bug, Cyrtopeltis modesta Distant, tomato bug, Dysdercus suturellus Herrich-Schffer, cotton stainer, brown bug Stink bug ( Euchistus servus Say, brown stink bug), one-spotted stink bug ( Euchistus variolarius Palisot de Beauvois, one-spotted stink bug), Graptόsthetus spp. (complex of wide-shielded stink bug), pine Leptoglossus corculus Say, leaf-footed pine seed bug, Lygus lineolaris Palisot de Beauvois, tarnished plant bug, Nezara viridula Linnaeus, southern green stink bug, Oebalus pugnax Fabricius, rice stink bug), Oncopeltus fasciatus Dallas, large milkweed bug, Pseudatomoscelis seriatus Reuter, cotton fleahopper.

Other insect orders controlled by the compounds of formula (I) of the present invention include: Thysanoptera (for example, Western flower thrips ( Frankliniella occidentalis Pergande, western flower thrips), citrus thrips ( Scirthothrήps citri Moulton, citrus thrips), soybean thrips ( Sericothrips variabilis Beach, soybean thrips) and onion thrips ( Thrips tabaci Lindeman, onion thrips)); and Coleoptera (e.g., potato beetle ( Leptinotarsa decemlineata Say, Colorado potato beetle), Mexican bean beetle ( Epilachna varivestis Mulsant, Mexican bean beetle) and nematodes of the genus Agriotes, Athous or Limonius).

In particular, the compounds of the formula (I), their N-oxides, their isomers, their polymorphs and their salts are particularly suitable for use effectively against insects from the order of Lepidoptera, such as: Small cutworm ( Agrotis ypsilon ), yellow cutworm ( Agrotis segetum ), cottonleaf moth ( Alabama argillacea ), bean moth ( Anticarsia gemmatalis ), apple nest moth ( Argyresthia conjugella ), owl moth ( Autographa gamma ) , Bupalus piniarius , Cacoecia murinana , Capua reticulana , Cheimatobia brumata , Chilo infuscatellus , Choristoneura fumiferana ), Western spruce aphid ( Choristoneura occidentalis ), American armyworm ( Cirphis unipuncta ), codling moth ( Cydia pomonella ), European pine caterpillar ( Dendrolimus pini ), melon borer ( Diaphania nitidalis ), giant corn borer ( Diatraea grandiosella ), cotton bollworm ( Earias insulana ), square cotton bollworm ( Earias vittella ), small corn borer ( Elasmopalpus lignosellus ), grape moth ( Eupoecilia ambiguella ), European pine moth ( Evetria bouliana ), grain cutworm ( Feltia subterranea ), Galleria mellonella , Grapholita funebrana , Grapholita molesta , Helicoverpa armigera , Helicoverpa virescens , Helicoverpa zea , Cutworm moth ( Hellula undalis ), gray skirt looper moth ( Hibernia defoliaria ), American white moth ( Hyphantria cunea ), apple nest moth ( Hyponomeuta malellus ), tomato borer moth ( Keiferia lycopersicella ), hemlock looper moth ( Lambdina fiscellaria ), beet armyworm ( Laphygma exigua ), coffee leafminer ( Leucoptera coffeeella ), spinner leafminer ( Leucoptera scitella ), spotted leafminer ( Lithocolletis blancardella ), grape berry tumbler ( Lobesia botrana ), yellow green tapered moth ( Loxostege sticticalis ), Leucinodes orbonalis , Lymantria dispar , Lymantria monacha , Lyonetia clerkella , Malacosoma neustria , Mamestra brassicae , Douglas fir moth ( Orgyia pseudotsugata ), European corn borer ( Ostrinia nubilalis ), winter armyworm ( Panolis flammea ), red bollworm ( Pectinophora gossypiella ), variegated cutworm ( Peridroma saucia ), and round palm moth ( Phalera bucephala ) , potato tuber moth ( Phthorimaea operculella ), orange miner moth ( Phyllocnistis citrella ), cabbage butterfly ( Pieris brassicae ), alfalfa green armyworm ( Plathypena scabra ), diamondback moth ( Plutella xylostella ), soybean armyworm ( Pseudoplusia includens ), pine moth Spodoptera frugiperda _ _ _ _ Spodoptera litura , Spodoptera exigua , Thaumatopoea pityocampa , Tortrix viridana , Trichoplusia ni , and Zeiraphera canadensis and beetles ( Coleoptera ) such as Agrilus sinuatus, Agriotes lineatus , Agriotes obscurus , Amphimallus solstitialis, Anisandrus dispar ), cotton boll weevil ( Anthonomus grandis ), apple flower weevil ( Anthonomus pomorum ), euphoridae flea beetle ( Aphthona euphoridae ), red-tailed click beetle ( Athous haemorrhoidalis ), linear hidden weevil ( Atomaria linearis ), large pine small Weevil ( Blastophagus piniperda ), canopy leaf moth ( Blitophaga undata ), broad bean weevil ( Bruchus rufimanus ), pea weevil ( Bruchus pisorum ), lentil weevil ( Bruchus lentis ), apple leafroll weevil ( Byctiscus betulae ), beet weevil ( Cassida nebulosa ) , Bean leaf beetle ( Cerotoma trifurcata ), golden beetle ( Cetonia aurata ), cabbage pod weevil ( Ceuthorrhynchus assimilis ), stem weevil ( Ceuthorrhynchus napi ), beet freckle beetle ( Chaetocnema tibialis ), tobacco wireworm ( Conoderus vespertinus ), Crioceris asparagi , Ctenicera ssp. , Diabrotica longicornis , Diabrotica semipunctata , Diabrotica undecimpunctata ), Brazilian leaf beetle ( Diabrotica speciosa ), corn root leaf beetle ( Diabrotica virgifera ), Mexican bean beetle (Epilachna varivestis ), tobacco flea beetle ( Epitrix hirtipennis ), cotton borer ( Eutinobothrus brasiliensis ), pine weevil ( Hylobius abietis ), Egyptian clover weevil ( Hypera brunneipennis ), clover leaf weevil ( Hypera postica ) , spruce weevil ( Ips typographus ), barbed mud worm ( Lema bilineata ), black horned mud worm ( Lema melanopus ), potato Beetle ( Leptinotarsa decemlineata ), sugar beet beetle ( Limonius californicus ), rice weevil ( Lissorhoptrus oryzophilus ), cotton nematode ( Melanotus communis ), rape beetle ( Meligethes aeneus ), beetle beetle ( Melolontha hippocastani ), western five Moongill beetle ( Melolontha melolontha ), rice weevil ( Oulema oryzae ), black vine weevil ( Ortiorrhynchus sulcatus ), strawberry root weevil ( Otiorrhynchus ovatus ), horseradish ape leaf beetle ( Phaedon cochleariae ), pear cut leaf weevil ( Phyllobius pyri ), Phyllotreta chrysocephala , Phyllophaga sp. , Phyllotreta horticola , Phyllotreta nemorum , Phyllotreta striolata , Japan Beetles ( Popillia japonica ), pea leaf weevils ( Sitona lineatus ) and grain weevils ( Sitophilus granaria ); flies, mosquitoes ( Diptera ) such as Aedes aegypti , Aedes albopictus , Aedes vexans , Anastrepha ludens , Anopheles maculipennis , Anopheles crucians , Anopheles albimanus , Anopheles gambiae gambiae ), Anopheles freeborni , Anopheles leucosphyrus , Anopheles minimus , Anopheles quadrimaculatus , Calliphora vicina , Ceratitis medfly ( Ceratitis capitata ), maggot fly ( Chrysomya bezziana ), American golden fly ( Chrysomya hominivorax ), rice golden fly ( Chrysomya macellaria ), deer fly ( Chrysops discalis ), yellow ocher fly ( Chrysops silacea ), Atlantic spotted fly ( Chrysops atlanticus ), Cochliomyia hominivorax , Contarinia sorghicola , Cordylobia anthropophaga , Culicoides furens , Culex pipiens , black beard Culex nigripalpus , Culex quinquefasciatus , Culex tarsalis , Culiseta inornata , Culiseta melanura , Dacus cucurbitae , Dacus oleae , Dasineura brassicae , Delia antique , Delia coarctata , Delia platura , cabbage field fly ( Delia radicum ), Dermatobia hominis , Yellow-bellied fly ( Fannia canicularis ), Three-spotted grass fly ( Geomyza Tripunctata ), Gasterophilus intestinalis , Glossina morsitans , Glossina barbata Glossina palpalis , Glossina fuscipes , Glossina tachinoides , Haematobia irritans , Haplodiplosis equestris , Hippelates spp . ( Hylemyia platura ), Hypoderma lineata , Leptoconops torrens , Liriomyza sativae , Liriomyza trifolii , Lucilia caprina , Lucilia copper fly ( Lucilia cuprina ), Lucilia sericata , Lycoria pectoralis , Mansonia titillanus , Mayetiola destructor , Musca autumnalis , Musca domestica ), Muscina stabulans , Oestrus ovis , Opomyza florum , Oscinella frit , Pegomya hysocyami , Phorbia antiqua , Cabbage fly ( Phorbia brassicae ), wheat fly ( Phorbia coarctata ), silver-footed sandfly ( Phlebotomus argentipes ), Colombian scaled mosquito ( Psorophora columbiae ), carrot stem fly ( Psila rosae ), heterochromatic scaled mosquito ( Psorophora discolor ), mixed black mosquito ( Prosimulium mixtum ), cherry fruit fly ( Rhagoletis cerasi ), apple fruit fly ( Rhagoletis pomonella ), red-tailed meat fly ( Sarcophaga haemorrhoidalis ), meat fly species ( Sarcophaga sp. ), gnat ( Simulium vittatum ), gnat fly ( Stomoxys calcitrans ), gadfly ( Tabanus bovinus ), black gadfly ( Tabanus atratus ), gadfly ( Tabanus lineola ), afly ( Tabanus similis ), common gadfly ( Tipula oleracea ) and European gadfly ( Tipula paludosa ); termites genus ( Isoptera ) such as European wood termite ( Calotermes flavicollis ), common termite ( Leucotermes flavipes ), golden heterotermes ( Heterotermes aureus ), yellow-breasted termite ( Reticulitermes flavipes ), southern termite ( Reticulitermes virginicus ) , Reticulitermes lucifugus , Reticulitermes santonensis , Reticulitermes grassei , Termes natalensis and Coptotermes formosanus ; cockroaches (Blattaria Blattodea )), such as Blattella germanica , Blattella asahinae , Periplaneta americana, Periplaneta japonica , Periplaneta brunnea , Periplaneta smoke fuligginosa ), Periplaneta australasiae , and Blatta orientalis ; ants, bees, wasps, sawflies ( Hymenoptera ), such as Athalia rosae , leafcutter ants ( Atta cephalotes ), Atta capiguara , Atta cephalotes tropical , Atta laevigata , Atta robusta , Atta sexdens ), Texas Leafcutter Ant ( Atta texana ) , Crematogaster spp . Kitchen ants ( Monomorium pharaonis ), tropical fire ants ( Solenopsis geminata ), red fire ants ( Solenopsis invicta ), black fire ants ( Solenopsis richteri ), California fire ants ( Solenopsis xyloni ), red harvest ants ( Pogonomyrmex barbatus ), California harvest ants ( Pogonomyrmex californicus ), Pheidole megacephala , Dasymutilla occidentalis , Bombus spp. , Vespula squamosa , Paravespula vulgaris , Paravespula pennsylvanica , German wasp ( Paravespula germanica ), white-faced wasp ( Dolichovespula maculata ), yellow-fronted wasp ( Vespa crabro ), ocher wasp ( Polistes rubiginosa ), Florida ants ( Camponotus floridanus ) and Argentine ants ( Linepithema humile ); crickets , grasshoppers, locusts ( Orthoptera ), such as house crickets ( Acheta domestica ), European mole crickets ( Gryllotalpa gryllotalpa ), migratory locusts ( Locusta migratoria ), double-banded grasshoppers ( Melanoplus bivittatus ), red-legged grasshoppers ( Melanoplus femurrubrum ), Mexican grasshopper ( Melanoplus mexicanus ), migratory grasshopper ( Melanoplus sanguinipes ), rocky mountain grasshopper ( Melanoplus spretus ), red-winged grasshopper ( Nomadacris septemfasciata ), American grasshopper ( Schistocerca americana ), desert locust ( Schistocerca gregaria ), Moroccan grasshopper ( Dociost aurus maroccanus ), Tachycines aynamorus , Oedaleus senegalensis , Zonozerus variegatus , Hieroglyphus daganensis , Kraussaria angulifera , Calliptamus italicus ), Chortoicetes terminifera and Locustana pardalina ; Araneid a, such as black widow spiders ( Latrodectus mactans ) and brown recluse spiders ( Loxosceles reclusa ); fleas ( Siphonaptera ) , such as Ctenocephalides felis , Ctenocephalides canis , Xenopsylla cheopis , Pulex irritans , Tunga penetrans , and Nosopsyllus fasciatus ; Silverfish ( silverfish ) and housefish ( firebrat , Thysanura ) such as silverfish ( Lepismodes inquilinus ) and housefish ( Thermobia domestica ); centipedes ( Chilopoda ) such as Mediterranean sea gnat ( Scutigera oleoptrata ); millipede ( Diplopoda ), e.g. Narceus spp .; earwigs ( Dermaptera ), e.g. forficula auricularia ; lice ( Phthiraptera ) , such as Pediculus humanus capitis , Pediculus humanus corporis , Pthirus pubis , Haematopinus eurysternus , Haematopinus suis , Linognathus vituli , cattle Bird lice ( Bovicola bovis ), chicken lice ( Menopon allinae ), large chicken lice ( Menacanthus stramineus ) and small short-nosed cow lice ( Solenopotes capillatus ); of the order Collembola ( springtails ), e.g. Onychiurus ssp. ).

The compounds of formula (I) according to the present invention are suitable for controlling nematodes: plant parasitic nematodes, such as root knot nematodes (root knot nematodes ), northern root knot nematodes ( Meloidogyne hapla ), southern root knot nematodes ( Meloidogyne incognita ), Javan root knot nematodes Meloidogyne javanica and other Meloidogyne species; cyst-forming nematodes , Globodera rostochiensis and other Globodera species; wheat cyst nematodes ( Heterodera avenae ), soybean cyst nematode ( Heterodera glycines ), sugar beet cyst nematode ( Heterodera schachtii ), clover cyst nematode ( Heterodera trifolii ) and other cyst nematode ( Heterodera ) species; seed gall nematodes ( Seed gall nematodes ), grain Anguina species; Stem and foliar nematodes, Aphelenchoides species; Sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species species; Pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; Ring nematodes, Criconema species, Criconemella ) species, Criconemoides species, Mesocriconema species; Stem and bulb nematodes, Ditylenchus destructor , Ditylenchus dipsaci and other Ditylenchus species Ditylenchus species; Awl nematodes, Dolichodorus species; Spiral nematodes , Helicotylenchus multicinctus and other Helicotylenchus species; Sheath nematodes ( Sheath and sheathoid nematodes ), Hemicycliophora species and Hemicriconemoides species; Rice root nematodes ( Hirshmanniella ) species; Lance nematodes , Crown nematodes ( Hoploaimus ) species; Rhizoid false rootknot nematodes , Nacobbus species; Needle nematodes , Longidorus elongatus and other Longidorus species; Lesion nematodes ), Pratylenchus neglectus , Pratylenchus penetrans , Pratylenchus curvitatus , Pratylenchus goodeyi , and other Pratylenchus species; Burrowing nematodes, Radopholus similis and other Radopholus species; Reniform nematodes, Rotylenchus robustus and other Rotylenchus species; Scutellonema species; Stubby root nematodes, Trichodorus primitivus and other Trichodorus species, Paratrichodorus species; Dwarf root nematodes Stunt nematodes , tobacco dwarf nematodes ( Tylenchorhynchus claytoni ), adventitious dwarf nematodes ( Tylenchorhynchus dubius ) and other dwarf nematodes ( Tylenchorhynchus ) species; Tylenchulus species; Dagger nematodes , Xiphinema species; and other plant parasitic nematode species.

The compounds of formula (I) and salts thereof of the present invention are also effective for controlling arachnids ( arachnids ) (Arachnoidea ( Arachnoidea )), such as the order Acarina ( Acarina ), such as the secret beak tick family ( Argasidae ), Tick family ( Ixodidae ) and Sarcoptidae , such as Amblyomma americanum , Amblyomma variegatum , Argas persicus , Boophilus annulatus , Boophilus annulatus ( Boophilus decoloratus ), Boophilus microplus , Dermacentor silvarum , Hyalomma truncatum , Ixodes ricinus , Ixodes rubicundus , Ornithodorus moubata ), Otobius megnini , Dermanyssus gallinae , Psoroptes ovis , Rhipicephalus appendiculatus , Rhipicephalus evertsi , scabies mite ( Sarcoptes scabiei ); and Eriophyidae spp. , such as Aculus schlechtendali , Phylcoptrata oleivora , and Eriophyes sheldoni ; Tarsonemidae spp. , such as cyclamen ( Phytonemus pallidus ) and polyphagotarsonemus latus ( Polyphagotarsonemus latus ); fine beard mite ( Tenuipalpidae spp. ), such as purple pseudonych ( Brevipalpus phoenicis ); spider mite ( Tetranychidae spp. ), For example Tetranychus cinnabarinus , Tetranychus kanzawai , Tetranychus pacificus , Tetranychus telarius , Tetranychus urticae , Apple spider mite ( Panonychus ulmi ) , Panonychus citri and Oligonychus pratensis .

In one embodiment of the present invention, the present invention provides a compound of formula (I), which is useful for controlling insects selected from the group consisting of sucking or piercing insects, for example from the orders Thysanoptera, Diptera and Semiptera. Insects of the order Hemiptera, especially the following species: Thysanoptera: tobacco brown thrips ( Frankliniella fusca ), alfalfa thrips ( Frankliniella occidentalis ), flower thrips ( Frankliniella tritici ), orange thrips ( Scirtothrips citri ) , Thrips oryzae , Thrips palmi and Thrips tabaci ; Diptera: Aedes aegypti, Aedes albopictus, Aedes albopictus Aedes vexans , Anastrepha ludens , Anopheles maculipennis , Anopheles crucians , Anopheles albimanus , Anopheles gambiae , Anopheles freeborni , Anopheles leucosphyrus , Anopheles minimus , Anopheles quadrimaculatus , Calliphora vicina , Ceratitis capitata , Chrysomya bezziana , Chrysomya hominivorax , Chrysomya macellaria , Chrysops discalis , Chrysops silacea , Chrysops atlanticus , Cochliomyia hominivorax , Contarinia sorghicola , Cordylobia anthropophaga , Culicoides furens , Culex pipiens , Culex black bearded nigripalpus ), Culex quinquefasciatus , Culex tarsalis , Culiseta inornata , Culiseta melanura , Dacus cucurbitae , Bactrocera oleifera ( Dacus oleae ), Brassica gall fly ( Dasineura brassicae ), Onion field fly ( Delia antique ), Corn field fly ( Delia coarctata ), Gray field fly ( Delia platura ), Cabbage field fly ( Delia radicum ) , Dermatobia hominis , Fannia canicularis , Geomyza Tripunctata , Gasterophilus intestinalis , Glossina morsitans , Glossina palpalis ), Glossina fuscipes , Glossina tachinoides , Haematobia irritans , Haplodiplosis equestris , Hippelates spp. , Hylemyia platura , Hypoderma lineata , Leptoconops torrens , Liriomyza sativae , Liriomyza trifolii , Lucilia caprina , Lucilia cuprina , Lucilia sericata , Lycoria pectoralis , Mansonia titillanus , Mayetiola destructor , Musca autumnalis , Musca domestica , rot Muscina stabulans , Oestrus ovis , Opomyza florum , Oscinella frit , Pegomya hysocyami , Phorbia antiqua , Phorbia brassicae ), wheat fly ( Phorbia coarctata ), silver-footed sandfly ( Phlebotomus argentipes ), Colombian scaled mosquito ( Psorophora columbiae ), carrot fly ( Psila rosae ), heterochromatic scaled mosquito ( Psorophora discolor ), mixed black mosquito ( Prosimulium mixtum ) , cherry fruit fly ( Rhagoletis cerasi ), apple fruit fly ( Rhagoletis pomonella ), red-tailed meat fly ( Sarcophaga haemorrhoidalis ), meat fly species ( Sarcophaga spp. ), band gnat ( Simulium vittatum ), thorn fly ( Stomoxys calcitrans ), gadfly ( Tabanus bovinus ), black fly ( Tabanus atratus ), barbed horsefly ( Tabanus lineola ), pseudobara fly ( Tabanus similis ), common mosquito ( Tipula oleracea ) and European giant mosquito ( Tipula paludosa ); Hemiptera, especially Aphids : Acyrthosiphon onobrychis , Adelges laricis, Aphidula nasturtii , Aphis fabae , Aphis forbesi , Aphis pomi , Aphis gossypii , Aphis grossulariae , Aphis schneideri , Aphis spiraecola , Aphis sambuci , Pea aphid ( Acyrthosiphon pisum ), potato aphid Aulacorthum solani , Brachycaudus cardui , Brachycaudus helichrysi , Brachycaudus persicae , Brachycaudus prunicola, Brevicoryne brassicae Aphid ( Capitophorus horni ), Cerosipha gossypii , Strawberry capillary aphid ( Chaetosiphon fragaefolii ), Cryptomyzus ribis , Dreyfusia nordmannianae , Spruce aphid ( Dreyfusia piceae ), phylloxera ( Dysaphis radicola ), green potato aphid ( Dysaulacorthum pseudosolani ), apple pink aphid ( Dysaphis plantaginea ), pear aphid ( Dysaphis pyri ), broad bean leafhopper ( Empoasca fabae ), plum tailed aphid ( Hyalopterus pruni ), Hyperomyzus lactucae , Macrosiphum avenae , Macrosiphum euphorbiae , Macrosiphon rosae , Megoura viciae , Melanaphis pyrarius , Metopolophium dirhodum , Myzodes persicae , Myzus ascalonicus , Myzus cerasi , Myzus variants , Artemisia Aphid ( Nasonovia ribis-nigri ), brown rice lice ( Nilaparvata lugens ), pemphigus bursarius , sugarcane planthopper ( Perkinsiella saccharicida ), hop wart aphid ( Phorodon humuli ), apple psyllid ( Psylla mali ), Psylla piri , Rhopalomyzus ascalonicus , Rhopalosiphum maidis , Rhopalosiphum padi , Rhopalosiphum insertum , Mala Sappaphis mala , Sappaphis mali , Schizaphis graminum , Schizoneura lanuginosa , Sitobion avenae , Greenhouse whitefly ( Trialeurodes vaporariorum ) , large orange aphid ( Toxoptera aurantiiiand ) and grape phylloxera ( Viteus vitifolii ).

In one embodiment, the compound of formula (I) of the present invention can be used to control: diamondback moth (diamondback moth) (Plutella xylostella ( Plutella xylostella )); Cotton bollworm (cotton bollworm) ( Helicoverpa armigera ); fall armyworm ( Spodoptera frugiperdd )); cutworm (Tobacco cutworm); cluster caterpillar; Fabricius ( Spodoptera litura )); western flower thrips ( western flower thrips) ( Frankliniella occidentalis ); potato leafhopper ( Empoasca fabae ); cotton melon aphid ( Aphis gossypii ); green green peach aphid ( Myzus persicae ); sweet potato whitefly ( Bemisia tabaci ); and brown planthopper Stal ( Nilaparvata lugens ).

In one embodiment, the present invention provides a composition comprising an effective amount of a compound of formula (I) and at least one additional bioactive compatible compound selected from the group consisting of fungicides, insecticides, nematocides, Acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers and nutrients. The compounds used in the compositions and combinations with compounds of formula (I) are also referred to as active compatible compounds.

Known and reported fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics and nutrients can be combined with at least one compound of formula (I) according to the invention. For example, fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, Fertilizers and nutrients may be combined with at least one compound of formula (I) according to the invention.

Fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers and nutrients reported in PCT Patent Publication No. WO2016156129 and/or PCT Patent Publication No. WO2017153200 by reference is incorporated herein as a non-limiting example in combination with at least one compound of formula (I) according to the invention.

In particular, the compounds of the present invention may be mixed with at least one additional biologically active compatible compound (mixing pair), which includes, but is not limited to, insecticides, fungicides, nematocides, bactericides, acaricides, growth regulators ( such as rooting stimulants, chemical fungicides, semiochemicals, repellents, attractants, pheromones, feeding stimulants, other bioactive compounds) or entomopathogenic bacteria, viruses or fungi to form a multi-component pesticide , providing a wider range of agricultural uses.

Examples of such biologically active compounds or agents/mixture pairs with which the compound of formula (I) of the present invention can be combined/formulated are disclosed in PCT Patent Publication No. WO2019072906A1 (pages 27 to 37).

In one embodiment, biological agents for use in admixture with the compounds of the invention include Bacillus thuringiensis, Bacillus thuringiensis delta endotoxin, and naturally occurring and genetically modified viral insecticides, It includes members of the family Baculoviridae as well as entomophagous fungi.

In some cases, resistance management will be especially beneficial in combination with other invertebrate pest control compounds, or agents with similar control spectrum but different modes of action. Accordingly, the compositions of the present invention may further comprise a biologically effective amount of at least one additional invertebrate pest control compound or agent having a similar control range but a different mode of action. Contacting plants or plant loci genetically modified to express plant protection compounds (eg proteins) with a biologically effective amount of a compound of the invention may also provide broader plant protection and facilitate resistance management.

In one embodiment of the present invention, the biologically effective amount of the compound of formula (I) in the composition is by weight, relative to 0.1% to 99% of the total weight of the composition, preferably by weight , 5% to 50% relative to the total weight of the composition.

The present invention also provides a method of controlling an invertebrate pest, the method comprising: allowing the invertebrate pest, its habitat, breeding ground, food supply, plant, seed, soil, area, material, or the invertebrate pest that is growing or likely to A growing environment, or a material, plant, seed, soil, surface or space to be protected from pest attack or infestation and a biologically effective amount of a compound of formula (I), its agriculturally acceptable salt, stereoisomeric Conformers, diastereomers, enantiomers, tautomers, metal complexes, polymorphs, or N-oxides, compositions, or combinations thereof.

Control of invertebrate pests and protection of agronomic, horticultural and specialty crops, animal and human health by applying an effective amount of one or more compounds of the present invention to the pest environment (including agronomic and/or non-agronomic crop infestation) , Apply to the area to be protected, or directly to the pests to be controlled. Accordingly, the present invention further includes methods of controlling foliar and soil invertebrates and protecting agronomic and/or nonagronomic crops, the method comprising administering an invertebrate or an environmentally and biologically effective amount of one or A plurality of compounds of the invention are contacted, or with a composition comprising at least one such compound, or comprising at least one such compound and an effective amount of at least one additional biologically active compound or agent. A preferred method of contact is by spraying. Alternatively, granular compositions comprising a compound of the invention may be applied to plant foliage or to the soil. The compounds of the invention may also be produced by contacting the plants with a composition comprising the compounds of the invention applied as a soil drench of a liquid formulation, a granular formulation applied to the soil, a nursery box treatment or by dipping of transplants. Plant uptake for efficient delivery. Other methods of exposure include via direct and residual sprays, air sprays, gels, seed coatings, microencapsulation, systemic absorption, baits, ear tags, boluses, nebulizers, fumigants, aerosols, dusts, and many others or administer the compound or composition of the present invention.

The compounds of the invention may be incorporated into baits that are consumed by invertebrate pests or used in devices such as traps, bait stations and the like. Granules or baits containing 0.01%-5% active ingredient, 0.05%-10% humectant, and 40%-99% vegetable powder, which can be used at very low application rates, especially by ingestion rather than by direct Effective control of soil insects at contact lethal doses of the active ingredient. The compounds of the invention may be used in their pure form, but most commonly they will be in formulations comprising one or more compounds with suitable carriers, diluents and surfactants, and possibly in combination with food products depending on the intended end use. Preferred methods of application include spraying an aqueous dispersion of the compound or a refined oil solution. Combinations with spray oils, spray oil concentrates, spreading agents, adhesives, adjuvants, other solvents and synergists such as piperonyl butoxide often enhance compound efficacy.

The rate of application required for effective control (i.e. "biologically effective amount") should be considered in terms of the species of invertebrate to be controlled, the life cycle of the pest, its life stage, its size, location, season , host crop or animal, feeding behaviour, mating behaviour, ambient humidity, temperature and the like. Under normal circumstances, an application rate of about 0.01 kg to 2 kg of active ingredient per hectare is sufficient to control pests in agroecosystems, but as little as 0.0001 kg per hectare may be sufficient or as much as 8 kg per hectare may be required of. For non-agronomic applications, effective application rates should be in the range of about 1.0 mg/m2 to 50 mg/m2, but as little as 0.1 mg/m2 may be sufficient or as much as 150 mg/m2 Meters may be required. The biologically effective amount required for the desired degree of invertebrate pest control can be readily determined by one of ordinary skill in the art.

The term "animal pest" includes arthropods, gastropods and nematodes. According to the present invention, preferred animal pests are arthropods, preferably insects and arachnids, especially insects. Insects, which are especially associated with crops, are often referred to as crop insect pests.

Animal pests (i.e. arthropods, gastropods and nematodes), plants, the soil or water on which the plants grow can be treated with the compound of formula (I), its N-oxide And salt, or the composition contacting that comprises formula (I) compound, its N-oxide and salt. The term "contact" as used herein includes direct contact (application of the compound/composition directly to the animal pest or plant, usually to the leaves, stems or roots of the plant) and indirect contact (application of the compound/composition to the animal pest or plant location).

The compound of the present invention or the pesticidal composition comprising said compound can be used to protect growing plants/crops from animal pests (especially Insecta, Acaridae or Arachnida) attack or infestation. The term "crop" refers to both growing and harvested crops.

The compounds according to the invention are also suitable for combating or controlling animal pests. Accordingly, the present invention also relates to a method for combating or controlling animal pests, comprising: causing the animal pest, its habitat, breeding ground, or food supply, or crops, plants, plant propagation material (such as seeds), or animals Contact of the soil, or area, material or environment where a pest is growing or likely to grow, with a pesticidally effective amount of a compound of the invention.

In one embodiment, the present invention provides a method for protecting crops from attack or infestation by invertebrate pests, the method comprising: reacting the crops with a biologically effective amount of the compound or composition of the present invention, its isomer substances, polymorphs, N-oxides or salts.

The compound of the present invention per se or in the form of a composition is protected from insecticidal attack by applying an insecticidally effective amount of the active compound to insects or plants, plant propagation material (such as seeds, soil, surfaces, materials or Space). The above-mentioned application can be carried out before and after the plants, plant propagation material (eg seeds, soil, surface, material or space) have been infested by insects.

In one embodiment, the present invention provides a method for protecting seeds from soil insects and protecting seedling roots and shoots from soil and foliage insects, the method comprising: prior to sowing and/or germination, exposing the seeds to The compound or composition of the present invention, its N-oxide or salt is contacted.

Furthermore, the present invention provides a method for treating or protecting animals from infestation or infection by parasites, the method comprising: administering a biologically effective amount of the compound or composition of the present invention, its isomers, polymorphs The crystalline form, N-oxide or veterinarily acceptable salt is administered orally, topically or parenterally to the animal.

For the treatment of agricultural crops, the application rate (application effective dose) of the compound of the present invention may be in the range of 1 gram of active ingredient (g a.i.) to 5000 grams of active ingredient (g a.i.) per hectare of agricultural or horticultural crops, preferably 25 grams to 600 grams per hectare, more preferably 50 grams to 500 grams per hectare.

The compounds and compositions of the present invention are especially suitable for controlling a large number of insects on various cultivated plants such as cereals, root crops, oil crops, vegetables, spices, ornamentals such as durum and other wheat seeds, barley , oats, rye, corn (feed corn and sugar corn/sweet corn and common corn), soybeans, oil crops, cruciferous plants, cotton, sunflowers, bananas, rice, rape, radish rape, sugar beet, fodder beet, eggplant , potatoes, grasses, lawns, turf, forage grasses, tomatoes, leeks, pumpkin/squash, cabbage, iceberg lettuce, peppers, cucumbers, melons, Brassica species, melons, Beans, peas, garlic, onions, carrots, tubers such as potatoes, sugar cane, tobacco, grapes, petunia, geranium/pelargoniums, pansies and impatiens.

In particular, the compounds or compositions of the present invention can be used to protect agricultural crops such as cereals, corn, rice, soybeans and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any horticultural plants, Cucurbitaceae , oily plants, tobacco, coffee, tea, cocoa, sugar beet, sugar cane, cotton, potato, tomato, onion, pepper and other vegetables and ornamental plants.

The compounds of the present invention are effective both through contact (through soil, glass, walls, mosquito nets, carpets, plant parts or animal parts) and ingestion (baits or plant parts).

The compounds of the invention are also useful against non-crop invertebrate pests such as ants, termites, wasps, flies, mosquitoes, crickets or cockroaches. For use against said non-crop pests, the compounds of the invention are preferably used in bait compositions.

The term "non-crop insect pest" as used herein refers to pests of particular relevance to non-crop targets, such as ants, termites, wasps, flies, ticks, mosquitoes, crickets or cockroaches.

Baits can be liquid, solid or semi-solid formulations (eg gels). Solid baits can be formed into various shapes and forms suitable for individual application, such as granules, blocks, sticks, discs. Liquid baits can be filled in various devices such as open containers, sprinklers, droplet sources or evaporation sources to ensure proper application. Gels can be based on aqueous or oily bases and can be formulated to specific needs in terms of viscosity, water retention or aging characteristics.

The bait used in the composition is a product that is sufficiently attractive to induce insects such as ants, termites, wasps, flies, mosquitoes, crickets, etc. or cockroaches to eat the bait. Attraction can be manipulated by the use of feeding stimulants or sex pheromones. Food stimulants are selected from, for example, but not limited to, animal and/or vegetable proteins (meat meal, fish meal or blood meal, insect parts, egg yolk), fats and oils from animal and/or vegetable origin, or mono-organic sugars, Oligo- or polyorganic sugars, especially selected from sucrose, lactose, fructose, dextrose, glucose, starch, pectin or even molasses or honey. Fresh or decayed parts of fruits, crops, plants, animals, insects or specific parts thereof may also be used as feeding stimulants. Known pheromones are more insect specific. Specific pheromones are described in the literature and known to those skilled in the art.

When used in bait compositions, the typical content of the active ingredient is 0.001% to 15% by weight, ideally 0.001% to 5% by weight of active compound.

Formulations of the compounds of the invention in the form of aerosols (for example in spray cans), oil sprays or pump sprays are highly suitable for the non-professional user for controlling pests such as flies, fleas, ticks, mosquitos or cockroaches. The aerosol formulation is preferably composed of the following: active compound; solvent, such as low-carbon alcohol (such as methanol, ethanol, propanol, butanol), ketone (such as acetone, methyl ethyl ketone), with a temperature of about 50 ° C to 250 Paraffin hydrocarbons (such as kerosene), dimethylformamide, N-methylpyrrolidone, dimethylsulfoxide, aromatic hydrocarbons (such as toluene, xylene), water in the boiling point range of ℃; in addition, additives ( For example emulsifiers such as sorbitan monooleate, oleyl ethoxylates with 3 to 7 moles of ethylene oxide, fatty alcohol ethoxylates, perfume oils (e.g. essential oils), medium-carbon fatty acids esters with lower alcohols, aromatic carbonyl compounds); when appropriate, stabilizers (such as sodium benzoate), amphoteric surfactants, low-carbon epoxides, triethyl orthoformate; and when necessary, propellants (such as propane, butane, nitrogen, compressed air, dimethyl ether, carbon dioxide, nitrous oxide, or mixtures of these gases).

Oil spray formulations differ from aerosol formulations in that no propellant is used. When used in spray compositions, the content of the active ingredient is 0.001% to 80% by weight, preferably 0.01% to 50% by weight, most preferably 0.01% to 15% by weight of the active compound.

The compounds of the present invention and their respective compositions can also be used in mosquito coils and fumigation coils, chimneys, evaporator panels or long-term evaporators as well as moth papers, moth mats or other heat-independent evaporator systems.

The method of controlling infectious diseases transmitted by insects (such as malaria, dengue and yellow fever, lymphatic filariasis and leishmaniasis) using compounds of formula (I) and their respective compositions also includes treatment sheds Houses and housing surfaces, air spraying and impregnating curtains, tents, linen, mosquito nets, fly traps or the like. Insecticidal compositions for application to fibers, fabrics, knits, nonwovens, netting materials or foils and tarpaulins preferably comprise insecticides, optionally repellents and at least one adhesive the mixture. Suitable repellents are for example N,N -diethyl-m-toluamide (DEET), N,N -diethylphenylacetamide (DEPA), 1-(3-cyclohex-1-yl -Carbonyl)-2-methylpiperazine, (2-hydroxymethylcyclohexyl)acetolactone, 2-ethyl-1,3-hexanediol, indalone, methyl neodecylamide (MNDA), pyrethroids not used for insect control (such as {(+/-)-3-allyl-2-methyl-4-oxocyclopent-2-(+ )-alkenyl-(+)-trans-chrysanthemate (Esbiothrin)), repellents derived from or identical to plant extracts (e.g. limonene, eugenol, (+)-eucanol(1) (( +)-Eucamalol (1)), (-)-1-epi-eucamalol ((-)-l-epi-eucamalol)), or repellents derived from crude plant extracts of plants (e.g. limonamine (Eucalyptus maculata), Vitex rotundifolia, Palmarosa (Cymbopogan martinii), Lemongrass (Cymbopogan citratus), Citronella (Cymopogan nartdus)). Suitable binders are selected from, for example, polymers and copolymers of vinyl esters of aliphatic acids such as vinyl acetate and vinyl versatate, acrylates and methacrylates of alcohols such as acrylic acid butyl ester, 2-ethylhexyl ester and methyl acrylate), mono- and dienically unsaturated hydrocarbons (such as styrene) and aliphatic dienes (such as butadiene).

Impregnation of curtains and mosquito nets is generally carried out by dipping the fabric material in an emulsion or dispersion or spraying the emulsion or dispersion onto the net.

The compounds and mixtures of the present invention and their compositions can be used for the protection of wooden materials such as trees, wooden fences, sleepers, frames, works of art, etc. and buildings, and also for the protection of construction materials, furniture, leather, fibers, vinyl products , wires and cables, etc. from ants and/or termites, and to control ants and termites that cause damage to crops or humans (such as when pests invade houses and public facilities). The compounds of the present invention are not only applied to the surrounding soil surface or subfloor soil for the protection of wooden materials, but also to wood products (e.g. subfloor concrete surfaces, niche posts, beams, plywood, furniture, etc.), wood products (e.g. particleboard , half board, etc.) and vinyl products (such as coated wires, vinyl sheets, thermal insulation materials (such as foamed styrene), etc.).

In the case of application against ants that harm crops or humans, the compound of the present invention is applied to crops or surrounding soil, or directly to ant nests and the like.

seed treatment

The invention further provides a seed comprising a compound of the invention, especially the seed in an amount of about 0.0001% to about 1% by weight of the seed before treatment.

The compounds of the invention are also suitable for the treatment of seed for the protection of the seed from pests, especially soil-dwelling insect and acarid pests, and the roots and shoots of the resulting plants from soil and foliar pests.

The compounds of the invention are especially useful for protecting the seed from soil pests and the roots (white grubs, termites, nematodes) and shoots of the resulting plants from soil pests and foliar insects. It is preferred to protect the roots and shoots of the resulting plants. It is even more preferred to protect the shoots of the resulting plants from piercing-sucking insects, most preferably from aphids, jassids, thrips and whiteflies.

Accordingly, the present invention includes a method for protecting seeds from insects, especially soil insects, and seedling roots and shoots of the seeds from insects, especially soil and foliar insects, the method comprising: The seed is contacted with a compound of the invention prior to sowing the seed and/or after pregermination of the seed. Especially preferred is a method of protecting plant roots and shoots; more preferred is a method of protecting plant shoots from piercing and sucking insects; most preferred is a method of protecting plants The buds are free from aphid attack.

The term "seed" covers all kinds of seeds and plant propagules, including but not limited to true seeds, seed pieces, suckers, corms, bulbs, fruits, tubers, grains, cuttings, cuttings and the like, and In a preferred embodiment it is a real seed.

The term "seed treatment" includes all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dusting, seed soaking and seed pelleting.

The invention also includes seeds coated with or containing active compounds. These seeds can be coated with a seed coating composition comprising the compound of the present invention. For example, the seed coating composition is reported in European Patent No. EP3165092, European Patent No. EP3158864, PCT Patent Publication No. WO2016198644, PCT Patent Publication No. WO2016039623, PCT Patent Publication No. WO2015192923, Canadian Patent No. Patent Publication No. US2004237395, PCT Patent Publication No. WO2011028115, European Patent No. EP2229808, PCT Patent Publication No. WO2007067042, European Patent No. EP1795071, European Patent No. EP1273219, PCT Patent Publication No. WO200178507, European Patent No. EP1247436, Dutch Patent No. NL101 2918 and Canadian patents No. CA2083415.

The phrase "coated with and/or containing" generally means that the active ingredient is mostly on the surface of the propagation product at the time of application, although a greater or lesser portion of the ingredient may penetrate into the propagation product, depending on the method of application. When the propagation product is (re)planted, it can absorb the active ingredient and water.

Suitable seeds are e.g. seeds of cereals, root crops, oil crops, vegetables, spices, ornamental plants, e.g. durum wheat and other wheat, barley, oats, rye, corn (fodder corn and sugar corn/sweet corn and common corn) ), soybeans, oil plants, cruciferous plants, cotton, sunflower, banana, rice, rapeseed, turnip rape, sugar beet, fodder beet, eggplant, potato, grass, lawn, turf, fodder grass, tomato, leek, pumpkin/ Pumpkins, cabbage, iceberg lettuce, peppers, cucumbers, melons, Brassicas, melons, beans, peas, garlic, onions, carrots, tubers (e.g. potatoes), sugar cane, tobacco, grapes, petunia, geranium/ Seeds of geranium, pansies and impatiens.

In addition, the compounds according to the invention can also be used for the treatment of seeds from plants which have been bred (including genetically engineered) to be tolerant to the action of herbicides or fungicides or insecticides.

For example, the compounds of the present invention can be used for the treatment of seeds from plants for herbicidal activity selected from the group consisting of sulfonylureas, imidazolinones, glufosinate-ammonium or glyphosate-isopropylammonium and similar active substances. (See, e.g., European Patent No. EP242236, European Patent No. EP242246) (PCT Patent Publication No. WO92/00377) (European Patent No. EP257993, U.S. Patent Publication No. US5013659), or in genetically modified crop plants (such as cotton ), which have the ability to produce Bacillus thuringiensis toxin (Bt toxin) and make these plants resistant to certain pests (European Patent No. EP142924, European Patent No. EP193259).

Furthermore, the compounds according to the invention can be used for the treatment of seeds from plants which have modified properties compared to existing plants, which can be produced, for example, by conventional breeding methods and/or by generating mutants, or by recombinant procedures. For example, many cases have been described for the purpose of modifying starch synthesized in plants (e.g. PCT Patent Publication No. WO92/11376, PCT Patent Publication No. WO92/14827, PCT Patent Publication No. Recombinant modification of crop plants for the purpose of breeding crop plants (PCT Patent Publication No. WO91/13972).

Seed treatment application of the compounds according to the invention is carried out by spraying or sowing the plants before sowing and before emergence of the plants.

Compositions particularly suitable for seed treatment are, for example: A. Water Soluble Concentrates (SL, LS) B. Emulsions (EW, EO, ES) C. Suspensions (SC, OD, FS) D. Water Dispersible Granules and Water Soluble Granules (WG, SG) E. Water dispersible powder and water soluble powder (WP, SP, WS) F. Gel formulation (GF) G. Dustable powders (DP, DS)

Conventional seed treatment formulations include, for example, flowable concentrates (FS), solutions (LS), powders (DS) for dry treatments, water-dispersible powders (WS) for slurry treatments, water-soluble powders (SS) ) and emulsions (ES and EC) and gel formulations (GF). These formulations can be applied to seed diluted or undiluted. It can be applied directly to the seeds before sowing, or after they have germinated.

In one embodiment, the FS formulation is used for seed treatment. Typically, FS formulations may comprise 1-800 g/l of active ingredient, 1-200 g/l of surfactant, 0 to 200 g/l of antifreeze, 0 to 400 g/l of binder, 0 to 200 g /l of pigment and up to 1 liter of solvent, preferably water.

Other preferred FS formulations of the compounds of the invention for seed treatment comprise 0.1 to 80% by weight (1 to 800 g/l) of active ingredient, 0.1 to 20% by weight (1 to 200 g/l) of at least A surfactant, such as 0.05 to 5% by weight of a wetting agent and 0.5 to 15% by weight of a dispersant, up to 5 to 20% by weight (such as 5 to 20% by weight) of an antifreeze agent, 1 to 15% by weight (such as 1 to 15% by weight) of pigments and/or dyes, 0 to 40% by weight (e.g. 1 to 40% by weight) of binders (adhesives/adhesives), optionally up to 5% by weight (e.g. 0.1 to 5% by weight ), optionally 0.1 to 2% by weight of defoamers and optionally preservatives (such as biocides, antioxidants, etc., for example, in an amount of 0.01 to 1% by weight) and added to 100% by weight filler/carrier.

Seed treatment formulations may additionally contain binders and, optionally, colorants.

Binders may be added to improve the adhesion of the treated active material to the seed. Suitable binders are homopolymers and copolymers from alkylene oxides such as ethylene oxide or propylene oxide, ethylene-vinyl acetate copolymers, homopolymers and copolymers of acrylic acid, polyvinylamine, poly Acrylamide and polyvinylpyrimidine, polysaccharides (such as cellulose, cellulose and starch), homopolymers and copolymers of polyolefins (such as olefin/maleic anhydride copolymers, polyurethanes, polyesters, homopolymers of polystyrene substances and copolymers).

Optionally, coloring agents can also be included in the formulation. Colorants or dyes suitable for seed treatment formulations are Rhodamine B, C.I. Pigment Red 1 12, C.I. Solvent Red 1, Pigment Blue 15:4, Pigment Blue 15:3, Pigment Blue 15:2, Pigment Blue 15:1, Pigment Blue 80, Pigment Yellow 1, Pigment Yellow 13, Pigment Red 1 12, Pigment Red 48:2, Pigment Red 48:1, Pigment Red 57:1, Pigment Red 53:1, Pigment Orange 43, Pigment Orange 34, Pigment Orange 5, Pigment Green 36, Pigment Green 7, Pigment White 6, Pigment Brown 25, Basic Violet 10, Basic Violet 49, Acid Red 51, Acid Red 52, Acid Red 14, Acid Blue 9, Acid Yellow 23, Basic Red 10, Basic Red 108.

An example of a gelling agent is carrageenan ( ^Satiagel® ).

In seed treatment, the application rate of the compound of the present invention is generally 0.1 g to 10 kg per 100 kg of seeds, preferably 1 g to 5 kg per 100 kg of seeds, more preferably 1 g to 1000 g per 100 kg of seeds, especially It is 1 gram to 200 grams per 100 kilograms of seeds. Accordingly, the present invention also provides seed comprising a compound of formula (I) or an agriculturally acceptable salt of formula (I) as defined herein. The amount of the compound of formula (I) or its agriculturally acceptable salt is usually 0.1 g to 10 kg per 100 kg of seeds, preferably 1 g to 5 kg per 100 kg of seeds, especially 1 g to 1000 g per 100 kg of seeds .

animal health

The present invention also provides agricultural and/or veterinary compositions comprising at least one compound of formula (I).

In one embodiment, the present invention provides a compound of formula (I), an agronomically acceptable salt, an isomer/structural isomer, a stereoisomer, a diastereomer, a mirror image, a mutual Use of variants, metal complexes, polymorphs or N-oxide compositions or combinations thereof for combating invertebrate pests in crops and/or horticultural crops or parasites in animals.

The compounds of formula (I), their N-oxides and/or their veterinarily acceptable salts are also especially suitable for combating parasites in and on animals.

The present invention also provides a composition comprising a parasiticidally effective amount of at least one compound of formula (I), an N-oxide or a veterinarily acceptable salt thereof and an acceptable carrier, for use in controlling animals Parasites in the body and on animals.

The present invention also provides a method for treating, controlling, preventing and protecting animals from parasitic infestation and infestation, the method comprising administering or administering to the animal a parasiticidally effective amount of one of The compound of the present invention or a composition comprising the compound.

The present invention also provides a process for the preparation of a composition for treating, controlling, preventing or protecting animals from parasitic infestation or infestation, the composition comprising a parasiticidally effective amount of a compound of the present invention or comprising the The composition of the compound.

The activity of compounds against agricultural pests does not indicate their suitability for controlling endoparasites and ectoparasites in and on animals, which requires, for example, low non-emetic doses (in the case of oral application), metabolism in animals Compatibility, low toxicity and safe handling. It has surprisingly been found that the compounds according to the invention are suitable for combating endoparasites and ectoparasites in and on animals.

The compounds of the invention and compositions comprising the same are preferably used for the control and prevention of infestations and infestations of animals including warm-blooded animals (including humans) and fish. It is suitable, for example, for the control and prevention of infestation and infection of mammals such as cattle, sheep, swine, camels, deer, horses, pigs, poultry, rabbits, goats, dogs and cats, buffaloes , donkeys, yellow deer, and reindeer; and fur animals, such as mink, chinchilla, and raccoon; birds, such as chicken, geese, turkey, and duck; and fish, such as freshwater and saltwater fish, such as trout, carp, and eel.

The compounds of the invention and compositions comprising them are preferably used for the control and prevention of infestations and infections of domestic animals such as dogs or felines.

Infestations of warm-blooded animals and fish include, but are not limited to, lice, biting lice, ticks, nose worms, ticks, biting flies, moss flies, flies, myiasis larvae, chiggers, gnats, mosquitoes and fleas.

The compounds according to the invention and compositions comprising them are suitable for the systemic and/or non-systemic control of ectoparasites and/or endoparasites. It is active against all or part of the stages of development.

The compounds of the invention are especially useful against ectoparasites.

The compounds of the present invention are especially useful against parasites of the following orders and species, respectively: fleas ( Siphonaptera ), such as Ctenocephalides felis , Ctenocephalides cams , Indian rats Fleas ( Xenopsylla cheopis ), human fleas ( Pulex irritans ), latent fleas ( Tunga penetrans ) and striped rat fleas ( Nosopsyllus fasciatus ), cockroaches ( Blattaria Blattodea ), e.g. German cockroaches ( Blattella germanica ), Asian Cockroaches ( Blattella asahinae ), American cockroaches ( Periplaneta americana ), Japanese cockroaches ( Periplaneta japonica ), brown cockroaches ( Periplaneta brunnea ), black-breasted cockroaches ( Peroplaneta fuligginosa ), Australian cockroaches ( Periplaneta australasiae ) and oriental cockroaches ( Blatta orientalis ), flies, mosquitoes (Diptera), e.g. Aedes aegypti, Aedes albopictus , Aedes vexans , Anastrepha ludens , Anopheles maculipennis , Anopheles crucians , Anopheles albimanus , Anopheles gambiae , Anopheles freeborni , Anopheles leucosphyrus , Anopheles minimus , Anopheles quadrimaculatus , Calliphora vicina , Chrysomya bezziana , Chrysomya hominivorax , Chrysomya macellaria , Chrysops discalis , Chrysops silacea , Chrysops atlanticus , Cochliomyia hominivorax , Cordylobia anthropophaga , Culicoides furens , five-banded Culex pipiens , Culex nigripalpus , Culex quinquefasciatus , Culex tarsalis , Culiseta inornata , Culiseta melanura , horsefly ( Dermatobia hominis ), Fannia canicularis , Gasterophilus intestinalis , Glossina morsitans , Glossina palpalis , Glossina fuscipes , Glossina palpalis ( Glossina tachinoides ), Haematobia irritans , Haplodiplosis equestris , Hippelates spp. , Hypoderma lineata , Leptoconops torrens , Lucilia goatia ( Lucilia caprina ), Lucilia cuprina , Lucilia sericata , Lycoria pectoralis , Mansonia spp. , Musca domestica , rot fly ( Muscina stabulans ), sheep-nosed fly ( Oestrus ovis ), silver-footed sandfly ( Phlebotomus argentipes ), black rice field scaled mosquito ( Psorophora columbiae ), discolored scaled mosquito ( Psorophora discolor ), mixed gnat ( Prosimulium mixtum ), red-tailed white-tailed fly ( Sarcophaga haemorrhoidalis ), Sarcophaga sp. , spider gnat ( Simulium vittatum ), thorn fly ( Stomoxys calcitrans ), gadfly ( Tabanus bovinus ), black horsefly ( Tabanus atratus ), slender horsefly ( Tabanus lineola ) and zebra fly ( Tabanus similis ), lice ( Phthiraptera ) such as Pediculus humanus capitis , Pediculus humanus corporis , Pthirus pubis , cattle lice ( Haematopinus eurysternus ), pig lice ( Haematopinus suis ), Linognathus vituli , Bovicola bovis , Menopon gallinae , Menacanthus stramineus , Solenopotes capillatus , ticks and parasitoids Mites ( Parasitiformes ): Ticks (suborder Ixodida ) such as Ixodes scapularis, Ixodes holocyclus , Ixodes pacificus , brown Canine Tick ( Rhiphicephalus sanguineus ), Ann's Rocky Mountain Tick ( Dermacentor andersoni ), Dog Tick ( Dermacentor variabilis ), American Flower Tick ( Amblyomma americanum ), Gulf Ear Tick ( Ambryommama culatum ), Rodent Tick ( Ornithodorus hermsi ), relapsing fever ticks ( Ornithodorus turicata ) and parasitic mites ( Mesostigmata ), such as Ornithonyssus bacoti and Dermanyssus gallinae , Radiant mites ( Actinedida ) ( Prostigmata ) and Acaridida ( Astigmata ), e.g. Acarapis spp. , Cheyletiella spp. ), Ornithocheyletia spp. , Myobia spp. , Psorergates spp. , Demodex spp. , Trombicula spp. , Yak Listrophorus spp. , Acarus spp. , Tyrophagus spp. , Caloglyphus spp. , Hypodectes spp. ( Pterolichus spp. ), Psoroptes spp. , Chorioptes spp. , Otodectes spp. , Sarcoptes spp. , Notoedres spp. , Knemidocoptes spp. , Cytodites spp. and Laminosioptes spp. , stink bugs ( Heteropterida ): temperate bedbugs ( Cimex lectularius ), tropical bedbugs ( Cimex hemipterus ), Reduvius senilis , Triatoma spp. , Rhodnius ssp. , Panstrongylus ssp. and Arilus critatus , Liceida ( Anoplurida ), such as Haematopinus spp. , Linognathus spp. , Pediculus spp. , Phtirus spp. , and Solenopotes spp. , Mallophagida ( Arnblycerina and Ischnocerina ), such as Trimenopon spp. , Menopon spp. , Trinoton spp. ), Bovicola spp. , Werneckiella spp. , Lepikentron spp., Trichodectes spp. and Felicola spp .

Roundworms Nematoda : Wipeworms and Trichinosis ( Trichosyringida ), such as Trichinellidae ( Trichinella spp. ), (Trichinidae ( Trichuridae )), Trichuris spp. , Capillaria spp. , Rhabditida , e.g. Rhabditis spp ., Strongyloides spp. , Helicophalobus spp. , Strongylidae , e.g. Strongylus spp. , Ancylostoma spp. , Necator americanus , Bunostomum spp. ) ( Hookworm ), Trichostrongylus spp. , Haemonchus contortus . , Ostertagia spp. , Cooperia spp. , Nematodirus spp. , Dictyocaulus spp. , Cyathostoma spp. , Oesophagostomum spp. , Stephanurus dentatus , Pantocephala ( Ollulanus spp. ), Chabertia spp. , Stephanurus dentatus , Syngamus trachea , Ancylostoma spp. , Uncinaria spp . Globocephalus spp. , Necator spp. , Metastrongylus spp. , Muellerius capillaris , Protostrongylus spp . Blood nematodes ( Angiostrongylus spp. ), Parelaphosstrongylus spp. ( Parelaphosstrongylus spp. ), cat lungworm ( Aleurostrongylus abstrusus ) and kidney nematode ( Dioctophyma renale ), gastrointestinal roundworms ( Ascaridida ), e.g. human roundworm ( Ascaris lumbricoides ), Ascaris suum , Ascaridia galli , Parascaris equorum , Enterobius vermicularis ( Threadworm ), Toxocara canis , Toxascaris leonine ), Skrjabinema spp. and Oxyuris equi , Camallanida , e.g. Dracunculus medinensis ( Guinea worm ), From the order of Spirurida , e.g. Thelazia spp. , Wuchereria spp. , Brugia spp. , Onchocerca spp . Dirofilaria spp. , Dipetalonema spp. , Setaria spp. , Elaeophora spp. , Spirocerca lupi and horse stomach worms Habronema spp. , hookworms ( Acanthocephala ), such as Acanthocephalus spp. , Macracanthorhynchus hirudinaceus and Oncicola spp. ), Planarians ( Plathelminthes ): Flukes ( Trematoda ), eg Faciola spp. , Fascioloides magna , Paragonimus Paragonimus spp. , Dicrocoelium spp. , Fasciolopsis buski , Clonorchis sinensis , Schistosoma spp. , Schistosoma trichotillosum Trichobilharzia spp. , Alaria alata , Paragonimus spp. , Nanocyetes spp. , Cercomeromorpha , especially barworms ( Cestoda , Tapeworms ), such as Diphyllobothrium spp. , Tenia spp. , Echinococcus spp. , Dipylidium caninum, Multiceps spp. ), Hymenolepis spp. , Mesocestoides spp. , Vampirolepis spp. , Moniezia spp. Anoplocephala spp. ), Sirometra spp. , Anoplocephala spp. , and Hymenolepis spp. .

The compounds of formula (I) and compositions comprising them are especially useful for controlling pests of the orders Diptera, Fleas and Ticks.

In one embodiment, the present invention provides a use of a compound of formula (I) and a composition comprising the compound for combating mosquitoes.

In one embodiment, the present invention provides a use of a compound of formula (I) and a composition comprising the compound for combating flies.

In one embodiment, the present invention provides a use of a compound of formula (I) and a composition comprising the compound for combating fleas.

The use of the compound of formula (I) and the composition comprising the compound, which is used to fight against ticks, is also another embodiment of the present invention.

The compounds according to the invention are also particularly useful against endoparasites (Ascaris nematodes, hookworms and planarians).

In one embodiment, administration of the compounds of the invention can be done prophylactically as well as therapeutically.

In another embodiment, the administration of the compound of the invention is carried out directly or in a suitable formulation, either orally, topically/transdermally or parenterally.

For oral administration to warm-blooded animals, the compounds of the invention may be formulated as animal feeds, animal feed premixes, animal feed concentrates, pills, solutions, pastes, suspensions, drenches, gels, lozenges Doses, Boluses and Capsules. Alternatively, the compounds of the present invention can be administered to animals in the drinking water of the animals. For oral administration, the selected dosage form should provide the animal with 0.01 mg to 100 mg of the compound of the present invention per kilogram of animal body weight per day, preferably 0.5 mg to 100 mg of the compound of the present invention per kilogram of animal body weight per day.

Alternatively, compounds of the invention may be administered to animals parenterally, eg, by intrarumen, intramuscular, intravenous or subcutaneous injection. The compounds of the present invention can be dispersed or dissolved in a physiologically acceptable carrier for subcutaneous injection. Alternatively, the compounds of the invention may be formulated as implants for subcutaneous administration. Additionally, the compounds of the present invention can be administered to animals transdermally. For parenteral administration, the selected dosage form should provide the animal with 0.01 mg to 100 mg of the compound of the present invention per kilogram of animal body weight per day.

The compounds of the invention may also be in the form of dips, powders, powders, loops, wafers, sprays, shampoos, drop-and-pour formulations and in the form of ointments or oil-in-water or water-in-oil emulsions. applied to animals. For surface application, dips and sprays generally contain from 0.5 ppm to 5000 ppm and preferably from 1 ppm to 3000 ppm of the compound of the invention. Additionally, the compounds of the invention may be formulated as ear tags for use in animals, especially quadrupeds such as cattle and sheep.

Suitable formulations are: solutions such as oral solutions, concentrates for oral administration after dilution, solutions for application on the skin or in body cavities, pour-on formulations, gels; emulsions and suspensions for oral or transdermal administration. liquids; semisolid preparations; formulations in which the active compound is formulated in an ointment base or in an oil-in-water or water-in-oil emulsion base; solid preparations such as powders, premixes or concentrates, granules, pellets, tablets elixirs, boluses, capsules; aerosols and inhalants, and shaped articles containing active compounds.

Compositions suitable for injection are prepared by dissolving the active ingredient in a suitable solvent and optionally adding other ingredients such as acids, bases, buffer salts, preservatives and solubilizers.

The solution is sterile filtered and aseptically filled.

Suitable solvents are physiologically tolerated solvents, such as water; alkanols, such as ethanol, butanol, benzyl alcohol, glycerol, propylene glycol, polyethylene glycol; N-methyl-pyrrolidone; 2-pyrrolidone and mixtures thereof.

The active compounds can optionally be dissolved in physiologically tolerable vegetable or synthetic oils suitable for injection.

Suitable solubilizers are solvents which facilitate the dissolution of the active compound in the main solvent or prevent its precipitation. Examples are polyvinylpyrrolidone, polyvinyl alcohol, polyoxyethylated castor oil and polyoxyethylated sorbitan esters.

Suitable preservatives are benzyl alcohol, chlorobutanol, parabens and n-butanol.

Oral solutions are administered directly. Concentrates are administered orally after pre-diluted to the concentration used. Oral solutions and concentrates are prepared according to the prior art and as described above for injection solutions, and sterile procedures are not necessary.

Solutions for use on the skin are dripped, spread, wiped, sprayed or sprayed on.

Solutions for application to the skin are prepared according to the prior art and as described above for injection solutions, sterile procedures not being necessary.

Other suitable solvents are polypropylene glycol; phenylethyl alcohol; phenoxyethanol; esters such as ethyl or butyl acetate, benzyl benzoate; ethers such as alkyl glycol ethers (such as dipropylene glycol monomethyl ether) ; ketones such as acetone, methyl ethyl ketone; aromatic hydrocarbons; vegetable and synthetic oils; dimethylformamide; dimethylacetamide; diethylene glycol monoethyl ether (transcutol); solketal); propylene carbonate and mixtures thereof.

It is advantageous to add thickeners during preparation. Suitable thickeners are inorganic thickeners such as bentonite, colloidal silicic acid, aluminum monostearate; organic thickeners such as cellulose derivatives, polyvinyl alcohol and its copolymers, acrylates and methacrylic acid ester.

The gel is applied or spread on the skin or introduced into a body cavity. Gels are prepared by treating solutions prepared as described for injectable solutions with sufficient thickening agent formed from a clear material having an ointment-like consistency. The thickeners used are those listed above.

Pour-on formulations are poured or sprayed on a defined area of the skin and the active compound penetrates the skin and acts systemically. Pour-on formulations are prepared by dissolving, suspending or emulsifying the active compound in a suitable skin compatible solvent or solvent mixture. Where appropriate, other auxiliaries are added, such as coloring agents, bioabsorption-promoting substances, antioxidants, light stabilizers, adhesives.

Suitable solvents are, for example, water; alkanols; glycols; polyethylene glycols; polypropylene glycols; glycerol; aromatic alcohols such as benzyl alcohol, phenylethyl alcohol, phenoxyethanol; Benzyl benzoate; ethers, such as alkanediol alkyl ethers (such as dipropylene glycol monomethyl ether, diethylene glycol monobutyl ether); ketones, such as acetone, methyl ethyl ketone; cyclic carbonates, such as carbonic acid Propylene glycol esters, ethylene carbonate; aromatic and/or aliphatic hydrocarbons; vegetable or synthetic oils; DMF; dimethylacetamide; N-alkylpyrrolidones such as methylpyrrolidone, N-butyl N-ylpyrrolidone or N-octylpyrrolidone; N-methylpyrrolidone; 2-pyrrolidone; 2,2-dimethyl-4-oxy-methylene-1,3-dioxolane Or glycerol formal.

Suitable colorants are all colorants which are approved for use in animals and which are soluble or suspendable.

Suitable absorption-promoting substances are, for example, dimethylsulfene; spreading oils, such as isopropyl myristate, dipropylene glycol nonanoate, silicone oils and their copolymers with polyethers, fatty acid esters, Triglycerides, Fatty Alcohols.

Suitable antioxidants are sulfites or pyrosulfites (eg potassium metabisulfite), ascorbic acid, butylated hydroxytoluene, butylated hydroxyanisole, tocopherol.

A suitable light stabilizer is, for example, 2-phenylbenzimidazole-5-sulfonic acid (novantisolic acid). Suitable binders are eg cellulose derivatives, starch derivatives, polyacrylates, natural polymers, eg alginates, gelatin. Emulsions can be administered orally, transdermally, or by injection. Emulsions are either water-in-oil or oil-in-water.

This is achieved by dissolving the active compound in a hydrophobic phase or in a hydrophilic phase with the aid of suitable emulsifiers and, if appropriate, other auxiliaries (such as colorants, absorption-promoting substances, preservatives, antioxidants, light stabilizers, viscosity Reinforcing substances) are prepared by homogenizing it with other phase solvents.

Suitable hydrophobic phases (oils) are:

Liquid paraffin; silicone oil; natural vegetable oils such as sesame oil, almond oil, castor oil; synthetic triglycerides such as caprylic/capric acid with vegetable fatty acids of chain length C ₁ -C ₁₂ or other specially selected natural fatty acids Mixtures of diglycerides and triglycerides; mixtures of partial glycerides of saturated or unsaturated fatty acids which may also contain hydroxyl groups; monoglycerides and diglycerides of Cs-do fatty acids; fatty acid esters such as ethyl stearate, hexanoate Di-n-butyl diacid, hexyl laurate, dipropylene glycol nonanoate; esters of branched chain fatty acids of medium chain length with saturated fatty alcohols of chain length C ₁₆ -C ₁₈ ; isopropyl myristate; palm Isopropyl Acid; Caprylate/Caprate of Saturated Fatty Alcohol with Chain Length C ₁₂ -C ₁₈ ; Isopropyl Stearate; Oleyl Oleate; Decyl Oleate; Ethyl Oleate; Ethyl Lactate Esters; waxy fatty acid esters, such as synthetic duck tail fat, dibutyl phthalate, diisopropyl adipate and ester mixtures related to the latter; fatty alcohols, such as isotridecanol, 2 - octyldodecanol, cetylstearyl alcohol, oleyl alcohol; and fatty acids, such as oleic acid; and mixtures thereof. Suitable hydrophilic phases are: water, alcohols (eg propylene glycol, glycerol, sorbitol) and mixtures thereof.

Suitable emulsifiers are: Nonionic surfactants such as polyethoxylated castor oil, polyethoxylated sorbitan monooleate, sorbitan monostearate, monostearic acid Glycerides, polyoxyethyl stearate, alkylphenol polyglycol ethers; amphoteric surfactants such as disodium N-lauryl-p-iminodipropionate or lecithin.

Suitable anionic surfactants are, for example: sodium lauryl sulfate, fatty alcohol ether sulfate, mono/dialkyl polyethylene glycol ether orthophosphate monoethanolamine salt; suitable cationic active surfactants are: decachloride Hexaalkyltrimethylammonium.

Suitable further auxiliaries are: substances that increase viscosity and stabilize emulsions, such as carboxymethylcellulose, methylcellulose and other cellulose and starch derivatives, polyacrylates, alginates, gelatin, gum arabic ), polyvinylpyrrolidone, polyvinyl alcohol, copolymers of methyl vinyl ether and maleic anhydride, polyethylene glycol, waxes, colloidal silicic acid or mixtures of the mentioned substances.

Suspensions can be administered orally or topically/transdermally. They are prepared by suspending the active compounds in suspending agents, if appropriate by adding further auxiliaries such as wetting agents, colorants, bioabsorption-promoting substances, preservatives, antioxidants, light stabilizers.

Liquid suspensions are all homogeneous solvents and solvent mixtures.

Suitable wetting agents (dispersants) are the emulsifiers listed above.

Other auxiliaries which may be mentioned are those listed above.

Semisolid formulations can be administered orally or topically/transdermally. It differs from the aforementioned suspensions and emulsions only in that it has a higher viscosity.

To prepare solid preparations, the active compound is mixed with suitable excipients (via addition of auxiliaries where appropriate) and brought into the desired form.

Suitable excipients are all solid inert substances which are physiologically tolerable. Excipients used are inorganic or organic substances. Inorganic substances are, for example, sodium chloride, carbonates (eg calcium carbonate), bicarbonates, aluminum oxides, titanium oxides, silicic acid, clays, precipitated or colloidal silicas or phosphates. Organic substances are, for example, sugars, cellulose, food and feedstuffs (eg milk powder, animal meal, cereal meal and cereal shavings), starch.

Suitable auxiliaries are the preservatives, antioxidants and/or colorants already mentioned above.

Other suitable auxiliaries are lubricants and glidants, such as magnesium stearate, stearic acid, talc, bentonite; disintegration-promoting substances, such as starch or cross-linked polyvinylpyrrolidone; binders, such as starch, gelatin or linear polyvinylpyrrolidone; and anhydrous binders such as microcrystalline cellulose.

In general, "parasiticidally effective amount" means the amount of active ingredient required to achieve an observable effect on growth, including necrosis, death, delay, prevention and removal, destruction or otherwise reduction of the target Effects on the emergence and activity of living organisms. The parasiticidally effective amount of the various compounds/compositions used in the present invention may vary. The composition of a parasiticidally effective amount will also vary depending on prevailing conditions such as desired parasiticidal effect and duration, target species, mode of application, and the like. Compositions useful in the present invention generally contain from about 0.001% to 95% of a compound of the present invention.

In general, it is appropriate to administer the compounds of the present invention in a total amount of 0.5 mg/kg to 100 mg/kg per day, preferably 1 mg/kg to 50 mg/kg per day. The ready-to-use preparations contain 10 ppm to 80% by weight, preferably 0.1% to 65% by weight, more preferably 1% to 50% by weight, most preferably 5% by weight Up to 40% of compounds acting on parasites, preferably on ectoparasites. The preparations diluted before use contain the ectoparasite-acting compound in a concentration of 0.5% to 90% by weight, preferably 1% to 50% by weight. In addition, the formulations contain the anti-endoparasitic agents of the invention in a concentration of 10 ppm to 2% by weight, preferably 0.05% to 0.9% by weight, especially preferably 0.005% to 0.25% by weight. compound.

In a preferred embodiment, the compositions comprising the compounds of the invention are applied transdermally/topically.

In another embodiment, the surface application is in the form of shaped articles containing the compound, such as loops, discs, ear tags, strips and adhesive strips and foils for fixing on body parts.

It is generally advisable to apply a solid formulation releasing a total amount of 10 mg to 300 mg, preferably 20 mg to 200 mg, most preferably 25 mg to 160 mg, of the compound of the invention per kg body weight of the animal treated over a period of three weeks. thing.

In the preparation of shaped articles, thermoplastic and flexible plastics as well as elastomers and thermoplastic elastomers are used. Suitable plastics and elastomers are polyethylene resins, polyurethanes, polyacrylates, epoxy resins, cellulose, cellulose derivatives, polyamides and polyesters which are well compatible with the compounds of the invention. A detailed list of plastics and elastomers and the preparation procedures for shaped articles are listed in, for example, PCT Patent Publication No. WO2003086075.

Positive crop response:

The compounds of the present invention are not only effective in controlling insect and acarid pests, but also exhibit positive crop responses such as plant growth promoting effects (e.g. enhanced root growth and increased resistance to drought, high salinity, high temperature, cold, frost or light radiation receptivity), increased flowering, improved nutrient utilization (such as increased nitrogen assimilation), improved plant product quality, increased productive tiller (tiller) number, enhanced resistance to fungi, insects and pests, etc., thereby increasing Yield.

Without further elaboration, it is believed that anyone having ordinary skill in the art using the preceding description can utilize the present invention to its fullest extent. Therefore, the following examples should be construed as illustrative only and not limiting the present invention in any way.

Chemical example:

Process 6 :

The following examples illustrate, but are not limited to, the manner and method of preparing the compounds of the invention and include the best mode contemplated by the inventors for carrying out the invention.

process 6 :

step 1 : N-(2,4- Dimethoxybenzyl )-N-( C -2- alkyne -1- base ) C -2- alkyne -1- amine (N-(2,4-dimethoxybenzyl)-N-(prop-2-yn-1-yl)prop-2-yn-1-amine) (3) Synthesis

To (2,4-dimethoxyphenyl)methanamine (5.45 mL, 35.9 mmol) in tetrahydrofuran (100.0 mL) at 0 °C over a period of about 1 hour ) and triethylamine (20.01 mL, 144 mmol) was added dropwise to bromoprop-1-yne (16.42 mL, 144 mmol). The reaction mixture was stirred at 25 °C for 16 hours. The reaction mixture was quenched with water (200.0 mL) and then extracted with ethyl acetate (3 x 300.0 mL). The combined organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting crude material was purified by column chromatography on silica gel to give N-(2,4-dimethoxybenzyl)-N-(prop-2-yn-1- base) prop-2-yn-1-amine (N-(2,4-dimethoxybenzyl)-N-(prop-2-yn-1-yl)prop-2-yn-1-amine) (5.5 g, 22.61 mmol, yield 63.0%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.14 (d, J = 8.1 Hz, 1H), 6.52 (d, J = 2.2 Hz, 1H), 6.49 (dd, J = 8.3, 2.4 Hz, 1H ), 3.74 (d, J = 2.4 Hz, 6H), 3.50 (s, 2H), 3.30 (d, J = 2.4 Hz, 4H), 3.16 (t, J = 2.3 Hz, 2H); ESI MS (m/ z) 244.05 (M+1)

step 2 : 2-(2,4- Dimethoxybenzyl )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- ethyl carboxylate (Ethyl 2-(2,4-dimethoxybenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylate) (5)

N-(2,4-dimethoxybenzyl)-N-(prop-2-yn-1-yl)prop-2-yn-1-amine (7.5 g, 30.8 mmol) and ethyl carbonocyanidate (4.58 g, 46.2 mmol) in an ice-cold solution was flushed with nitrogen and degassed for 10 minutes, and chlorine (1,5-cyclooctadiene) (penta Chloro(1,5-cycloctadiene)(pentamethylcyclopentadienyl)ruthenium(II) (0.117 g, 0.308 mmol). The reaction mixture was allowed to stir for 1 h at 0 °C. The reaction mixture was quenched with water (100 mL) and then extracted with ethyl acetate (3 x 300.0 mL). The combined organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained crude material was purified by silica gel column chromatography to obtain 2-(2,4-dimethoxybenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c] Ethyl 2-(2,4-dimethoxybenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylate (4.5 g, 13.14 mmol, yield rate of 42.6%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.55 (s, 1H), 7.95 (s, 1H), 7.23 (d, J = 8.1 Hz, 1H), 6.55 (d, J = 2.4 Hz, 1H ), 6.50 (dd, J = 8.3, 2.4 Hz, 1H), 4.31 (q, J = 7.1 Hz, 2H), 3.92 (d, J = 5.6 Hz, 4H), 3.79 (s, 2H), 3.77 (s , 3H), 3.75 (s, 3H), 1.31 (t, J = 7.1 Hz, 3H); ESI MS (m/z) 342.9 (M+1)

step 3 : 2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- ethyl carboxylate -2,2,2- Ethyl trifluoroacetate (Ethyl 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylate 2,2,2-trifluoroacetate) (6)

2-(2,4-Dimethoxybenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid in trifluoroacetic acid (30 mL) A solution of ethyl ester (4.5 g, 13.14 mmol) was stirred under microwave irradiation at 140 °C for 60 min. The reaction mixture was cooled to 25 °C and concentrated under reduced pressure to give crude material which was dissolved in dichloromethane and water. The aqueous layer was separated and washed with dichloromethane. The aqueous layer was evaporated under reduced pressure to give ethyl 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylate-2,2,2-trifluoroacetate ( Ethyl 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylate 2,2,2-trifluoroacetate) (2.4 g, 7.84 mmol, 59.6% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.69 (s, 2H), 8.75-8.72 (m, 1H), 8.14-8.12 (m, 1H), 4.64 (d, J = 12.0 Hz, 4H) , 4.35 (q, J = 7.1 Hz, 2H), 1.33 (t, J = 7.1 Hz, 3H); ESI MS (m/z) 192.9 (M+1).

step 4 : Ethyl -2-(5-(3,5- Dichlorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- Carboxylate (ethyl 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carboxylate) (8) Synthesis

2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid ethyl ester-2,2 in butan-1-ol (65.0 mL), Ethyl 2-trifluoroacetate (6.3 g, 21.71 mmol) and 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole A solution of (3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole) (8.67 g, 23.88 mmol) was added dropwise to N , N -diisopropylethylamine ( N , N -Diisopropylethylamine) (11.37 mL, 65.1 mmol). The reaction mixture was heated to 80 °C for 16 hours. The reaction mixture was cooled to 25 °C and concentrated under reduced pressure to obtain crude material, which was purified by silica gel column chromatography to obtain ethyl-2-(5-(3,5-dichlorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid Salt (ethyl 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-carboxylate) (3.5 g, 7.38 mmol, yield 34.0%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.70 (s, 1H), 8.08 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d, J = 1.7 Hz, 2H ), 4.72 (d, J = 13.4 Hz, 4H), 4.37-4.30 (t, 2H), 4.11 (d, J = 17.1 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 1.34-1.30 (q, 3H); ESI MS (m/z) 473.5

step 5 : 2-(5-(3,5- Dichlorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- carboxylic acid (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxylic acid) (9) Synthesis

To ethyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) in tetrahydrofuran (40 mL) - A solution of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylate (4.0 g, 8.43 mmol) was added to lithium hydroxide monohydrate in water (1.06 g, 25.3 mmol). The reaction mixture was stirred at 25 °C for 16 hours. The combined organic layers were separated, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid (2-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid) (2.9 g, 6.50 mmol, 77% yield) . ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 6.17 (s, 1H), 5.56 (s, 1H), 5.30-5.28 (m, 1H), 5.12 (d, J = 1.8 Hz, 2H), 2.23 (d, J = 5.5 Hz, 4H), 1.57 (dd, J = 48.9, 17.1 Hz, 2H); ESI MS (m/z) 446.2

step 6 : 2-(5-(3,5- Dichlorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N-(1,1,1- Trifluoropropane -2- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- Formamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) (11) Synthesis

To 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid (0.2 g, 0.448 mmol), triethylamine (0.187 mL, 1.345 mmol) and 1,1,1-tri A solution of 1,1,1-trifluoropropan-2-amine (0.076 g, 0.672 mmol) was added to a solution of 1-1-propanephosphonic acid cyclic anhydride (1-1-propanephosphonic acid cyclic anhydride) ( 0.428 g, 0.672 mmol) (50% in ethyl acetate (EtOAc)). The reaction mixture was stirred at 25 °C for 16 hours. The reaction mixture was quenched with water and extracted three times with ethyl acetate, the combined organic layers were separated, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give crude material. The obtained crude material was purified by silica gel column chromatography to obtain 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxane Azol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) (0.097 g, 0.179 mmol, 40.0% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.12 (d, J = 9.3 Hz, 1H), 8.67 (s, 1H), 8.08 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.86-4.74 (m, 5H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 1.39 (d , J = 7.1 Hz, 3H), ESI MS (m/z) 540.40

Process 7 :

step 1 : Thiophene -2- methyl carboxylate (methyl thiophene-2-carboxylate) (13) Synthesis

Thiophene - 2 -carboxylic acid (thiophene-2-carboxylic acid) (5 g, 39.0 mmol) and sodium carbonate (8.27 g, 78 mmol) was added dropwise to methyl iodide (3.66 mL, 58.5 mmol). The reaction mixture was stirred at 25 °C for 16 hours. The resulting reaction mixture was dissolved in ethyl acetate (100 mL). The organic layer was washed with water (3 x 120 mL) and aqueous _NaHCO3 (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl thiophene-2-carboxylate (4.5 g, 31.7 mmol, 81% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.94 (dd, 6.4Hz,1H), 7.80 (dd, 6.4Hz,1H), 7.21 (m,1H), 3.80 (s, 3H).

step 2 : 4,5- pair ( Chloromethyl ) Thiophene -2- methyl carboxylate (methyl 4,5-bis(chloromethyl)thiophene-2-carboxylate carboxylate) (14) Synthesis

To a stirred solution of zinc chloride ( _2.88 g, 21.1 mmol) in chloromethyl methyl ether (chloromethyl methyl ether) (17.63 mL, 232 mmol) was added dropwise to chloromethyl Thiophene-2-carboxylate methyl ester (3 g, 21.1 mmol) in methyl ether (1.6 mL, 21.1 mmol). After complete addition, the resulting reaction mixture was stirred at 25 °C for 15 minutes. Next, the reaction mixture was stirred at 60 °C for 1 hour. Then, the reaction mixture was cooled and poured into ice water (100 mL), and extracted with ethyl acetate (2 x 100 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the product 4,5-bis(chloromethyl)thiophene-2-carboxylic acid methyl ester (methyl 4,5-bis(chloromethyl)thiophene-2- carboxylate carboxylate) (3 g, 21.1 mmol, yield 59%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.76 (s,1H), 5.12 (s, 2H), 4.83 (s, 2H), 3.82 (s, 3H).

step 3 : 5-(2,4- Dimethoxybenzyl )-5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- methyl carboxylate (methyl 5-(2,4-dimethoxybenzyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate) (15) Synthesis

To a stirred solution of methyl 4,5-bis(chloromethyl)thiophene-2-carboxylate (2 g, 8.36 mmol) in tetrahydrofuran (15 mL) was added dropwise in triethyl ether under _N2 atmosphere with stirring. ( _2,4 -dimethoxyphenyl)methanamine (1.27 mL, 8.3 mmol) in amine (Et3N) (3.50 mL, 25.0 mmol). After complete addition, the resulting reaction mixture was stirred for an additional 16 h at 25 °C. Then, excess THF was removed under reduced pressure, the residue was the reaction mixture and water (20 mL), and extracted with ethyl acetate (2 x 30 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude compound, which was purified by column chromatography to obtain 5-(2,4-dimethoxybenzyl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid methyl ester (methyl 5-(2,4-dimethoxybenzyl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxylate) (1 g, 3.0 mmol, 36% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.50 (s,1H), 7.25 (s,1H), 6.57-6.64 (m,2H),4.55 (s, 2H), 3.91 (m,2H) , 3.81 (s, 3H), 3.74 (S, 6H).

step 4 :methyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Carboxylate -2,2,2- Trifluoroacetate (methyl 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate 2,2,2-trifluoroacetate) (16) Synthesis

In a 20 mL biotage vial, 5-(2,4-dimethoxybenzyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- Methyl carboxylate (2.5 g, 7.5 mmol) was dissolved in trifluoroacetic acid (15 mL). The reaction mixture was irradiated for 50 min at 140 °C. Next, the reaction mixture was concentrated and diluted with 20 mL of water. The aqueous phase was washed with dichloromethane (3 x 20 mL). The aqueous layer was concentrated to give methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate-2,2,2-trifluoroacetate (methyl 5, 6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate 2,2,2-trifluoroacetate) (1 g, 3.0 mmol, 36% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.00 (s,1H), 7.76 (s,1H), 4.02 (s, 2H), 3.92 (s, 2H), 3.89(s, 2H), 3.85 (s, 3H), 3.83 (s, 3H), 3.80 (s, 3H).

step 5 :methyl -5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Carboxylate (methyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxylate) (18) Synthesis

With continuous stirring, methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate-2,2, To a stirred solution of 2-trifluoroacetate salt (0.73 g, 2.6 mmol) was added N , N -diisopropylethylamine (1.35 mL, 7.8 mmol). The reaction mixture was stirred for an additional 16 hours at 77 °C. The reaction mixture was concentrated under reduced pressure, and the crude product was purified by column chromatography to give methyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-( Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate (methyl 5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxylate) (0.63 g, 2.6 mmol, 50% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.76 (d, J = 6.4 Hz, 2H), 7.67 (s, 1H), 4.59 (s, 2H), 4.47 (s, 2H), 4.07 (d , J = 16.9 Hz, 2H), 3.80 (s, 3H), ESI MS (m/z) 482.35 (M) ⁺ .

step 6 : 5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- carboxylic acid (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxylic acid) (19) Synthesis

Under stirring, methyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro Isoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate (2.9 g, 6.0 mmol) and sodium hydroxide (0.48 g, 12.0 mmol) was added methanol (3.0 mL) and sodium hydroxide (0.48 g, 12.0 mmol) in water (15.0 mL). The desired product was extracted by using 10% methanol in dichloromethane solution, the combined organic layers were separated, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c] Pyrrole-2-carboxylic acid (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxylic acid) (2.20 g, 4.7 mmol, 78% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 13.12 (s,1H),7.76 (d, J = 6.4 Hz, 2H), 7.60 (s, 1H), 4.59 (s, 2H), 4.47 (s , 2H), 4.07 (d, J = 16.9 Hz, 2H), ESI MS (m/z) 470.80 (M) ⁺ .

step 7 : 5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N- Ethyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide) (20) Synthesis

5-(5-(3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5- Dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid (350 mg, 0.74mmol), azabenzene hexafluorophosphate Ethylamine ( 101 mg , 2.24 mmol). Then, the reaction mixture was stirred at 25 °C for 16 hours. In 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-di After the hydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid was consumed, the reaction mixture was diluted with cold water (20 mL) and allowed to stir for 20 minutes. The resulting precipitate was filtered, washed with hexane and dried under reduced pressure. The crude compound was dissolved in dimethylsulfoxide (3 mL) and purified by preparative HPLC to give 5-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) (170 mg, 0.34 mmol, yield 46%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.45 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.57 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.27-3.20 (m, 2H), 1.09 (t, J = 7.2 Hz , 3H), ESI MS (m/z) 495.90 (M) ⁺ .

Process 8 :

step 1 : 3- Methylthiophene -2- methyl carboxylate (methyl 3-methylthiophene-2-carboxylate) (22) Synthesis

To 3-methylthiophene-2-carboxylic acid (3-methylthiophene-2-carboxylic acid) (10 g, 70.3 mmol) in N , N -dimethylformamide (70 mL) during about 5 minutes ) and sodium carbonate (14.91 g, 141 mmol) was added dropwise to methyl iodide (6.60 mL, 106 mmol). The reaction mixture was stirred at 25 °C for 16 hours. The resulting reaction mixture was dissolved in ethyl acetate (200 mL). The organic layer was washed with water (2 x 100 mL) and aqueous NaHCO ₃ (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 3-methylthiophene-2-carboxylate (methyl 3- methylthiophene-2-carboxylate) (10 g, 64.0 mmol, yield 91%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.76 (d, J=4.8Hz,1H), 7.06 (d, J=4.8Hz,1H), 3.77 (s, 3H), 2.43 (s, 3H ).

step 2 : 4,5- pair ( Chloromethyl ) Thiophene -2- methyl carboxylate (methyl 4,5-bis(chloromethyl)thiophene-2-carboxylate carboxylate) (23) Synthesis

A stirred solution of zinc chloride (8.72 g, 64.0 mmol) in _chloromethyl methyl ether (53.5 mL, 704 mmol) was added dropwise to chloromethyl methyl ether (4.86 mL , 64.0 mmol) in 3-methylthiophene-2-carboxylate (methyl 3-methylthiophene-2-carboxylate) (10 g, 64.0 mmol). After complete addition, the resulting reaction mixture was stirred at 25 °C for 15 minutes. Next, the reaction mixture was stirred at 60 °C for 1 hour and cooled to 25 °C. The reaction mixture was poured into ice water (200 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the product 4,5-bis(chloromethyl)thiophene-2-carboxylic acid methyl ester (methyl 4,5-bis(chloromethyl)thiophene-2- carboxylate carboxylate) (7.5 g, 35.2 mmol, 89% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 5.12 (s, 2H), 4.81 (s, 2H), 3.79 (s, 3H), 2.49 (s, 3H).

step 3 : 5-(2,4- Dimethoxybenzyl )-3- methyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- methyl carboxylate (methyl 5-(2,4-dimethoxybenzyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate) (24) Synthesis

Under _N2 atmosphere, 4,5-bis(chloromethyl)-3-methylthiophene-2-carboxylic acid methyl ester (8.00 g, 31.6 mmol) and triethylamine (Et ₃ N) (17.62 mL, 126 mmol) was added dropwise to a stirred solution of (2,4-dimethoxyphenyl)methanamine (9.61 mL, 63.2 mmol). After complete addition, the resulting reaction mixture was stirred for an additional 16 h at 25 °C. Excess tetrahydrofuran was removed under reduced pressure and diluted with water (20 mL) and extracted with ethyl acetate (2 x 20 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a crude residue which was purified by column chromatography to give 5-(2,4-dimethoxybenzyl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid methyl ester (methyl 5-(2,4-dimethoxybenzyl)-3-methyl-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate) (7 g, 31.6 mmol, 64% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.20 (d, J=8.0Hz,1H), 6.58-6.53 (m, 2H), 6.64 (s, 2H), 4.81 (s, 2H), 3.91 (m, 2H), 3.81 (s, 3H), 3.74 (S, 6H), 2.49 (s, 3H), ESI MS (m/z) 482.80 (M) ⁺ .

step 4 :methyl -3- methyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Carboxylate -2,2,2- Trifluoroacetate (methyl 3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate 2,2,2-trifluoroacetate) (25) Synthesis

In a 20 mL biomarker vial, 5-(2,4-dimethoxybenzyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 - Methyl carboxylate (2 g, 5.76 mmol) was dissolved in trifluoroacetic acid (10 mL). The reaction mixture was irradiated and stirred in the microwave at 140 °C for 50 minutes. Then, the reaction mixture was concentrated, diluted with 20 mL of water and washed with dichloromethane (3 x 30 mL). The aqueous layer was concentrated to give methyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate-2,2,2-trifluoroacetic acid salt (methyl 3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate 2,2,2-trifluoroacetate) (1.2 g, 5.7 mmol, 70% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.00 (s,1H), 4.56(s, 2H), 4.35 (s, 2H), 3.79(s, 3H), 3.85 (s, 3H), 2.49 (s, 3H).

step 5 :methyl -5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-3- methyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Carboxylate (methyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxylate) (26) Synthesis

To methyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid in butan-1-ol (20 mL) at 25 °C Salt-2,2,2-trifluoroacetate (1.16 g, 3.9 mmol) and 3-bromo-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- Stirred solution of 4,5-dihydroisoxazole (3-bromo-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole) (1.5 g, 3.9 mmol) Add N,N-diisopropylethylamine (2 mL, 11.8 mmol). Next, the reaction mixture was stirred at 77 °C for 16 hours. The reaction mixture was concentrated under reduced pressure, and the crude residue was purified by column chromatography to give methyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(tri Fluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate (methyl 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxylate) (0.5 g, 3.94 mmol, 26% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.00 (s, 1H), 7.89 (d, 6.4 Hz, 1H), 7.76 (d, 6.4 Hz, 1H), 4.61 (s, 2H), 4.47 ( s, 2H), 4.07 (d, J = 16.9 Hz, 2H), 3.80 (s, 3H), 2.90 (s, 3H).

step 6 : 5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-3- methyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- carboxylic acid (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxylic acid) (27) Synthesis

Methyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- A stirred solution of 3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylate (2 g, 4.0 mmol) was added in water (10 mL) in methanol (10 mL) and lithium hydroxide monohydrate (0.67 g, 16.0 mmol). The resulting reaction mixture was stirred at 25 °C for 16 hours. After completion of the reaction, the reaction mixture was evaporated under reduced pressure, and the resulting crude product was dissolved in water and acidified with 2 M HCl. The desired product was extracted three times with 10% methanol in dichloromethane, the combined organic layers were separated, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 5-(5-(3,5-dichloro-4 -Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxylic acid (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5, 6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid) (1.5 g, 3.10 mmol, 77% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 13.10 (s,1H),7.76 (d, J = 1.6 Hz, 2H), 4.60 (s, 2H), 4.45 (s, 2H), 4.07 (d , J = 16.9 Hz, 2H), 2.31 (s, 3H), ESI MS (m/z) 482.80 (M) ⁺ .

step 7 : 5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N- Ethyl -5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide) (28) Synthesis

5-(5-(3,5-dichloro-4-fluorophenyl) -5- (trifluoromethyl) -4,5- Dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid (0.517 mL, 0.5 mmol), hexafluoro To a stirred solution of phosphate azabenzotriazole tetramethylurea (HATU) (295 mg, 0.77 mmol) and N,N-diisopropylethylamine (0.36 mL, 2.0 mmol) was added ethylamine (101 mg, 2.2 mmol). Then, the reaction mixture was stirred at 25 °C for 16 hours. In 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl- After 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid was consumed, the reaction mixture was diluted with cold water (20 mL) and allowed to stir for another 20 minutes. The resulting precipitate was filtered, washed with hexane and dried under reduced pressure. The crude compound was dissolved in dimethylsulfoxide (3 mL) and purified by preparative HPLC column chromatography to give 5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carboxamide) (118 mg, 0.52 mmol, 46% yield). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.92 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.59 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H), 3.24-3.17 (m, 2H), 2.27 (d, J = 15.0 Hz, 3H), 1.08 (t , J = 7.2 Hz, 3H), ESI MS (m/z) 409.40 (M) ⁺ .

Process 9 :

step 1 : 2-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N-( C -2- alkyne -1- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2 ,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) (30)

Add 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid (2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid)(2.01 g, 4.33 mmol), C- A stirred solution of 2-yn-1-amine (0.555 mL, 8.66 mmol) and N , N -diisopropylethylamine (DIPEA) (3.03 mL, 17.32 mmol) was added propanephosphonic acid anhydride (50 % solution in ethyl acetate) (6.16 mL, 8.66 mmol). The resulting reaction mixture was heated to 25 °C and stirred for 2 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain crude material, which was purified by Combi Flash ^® column chromatography to obtain 2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) (1.68 g, 3.35 mmol, yield 77%). ¹ H-NMR (400 MHz, DMSO-D6) δ 9.12 (t, J = 6.0 Hz, 1H), 8.64 (d, J = 0.7 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.73 (s, 4H), 4.12-3.97 (m, 4H), 3.07 (t, J = 2.4 Hz, 1H) ESI MS (m/z) 500.40 (M-1).

step 2 : Ethyl -(2-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- Carbonyl )( C -2- alkyne -1- base ) Urethane (ethyl (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carbonyl)(prop-2-yn-1-yl)carbamate) (31)

2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) in N , N -dimethylformamide (4 mL) at 0 °C )-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine - To a stirred solution of 6-formamide (330 mg, 0.658 mmol) was added NaH (52.7 mg, 1.317 mmol). The reaction mixture was stirred for 30 minutes, then ethyl carbonochloridate (0.125 mL, 1.317 mmol) was added dropwise at 0 °C. The resulting reaction mixture was stirred at 25 °C for 16 hours. After completion of the reaction, the reaction mixture was quenched with water and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained crude material was purified by preparative high performance liquid chromatography to obtain ethyl-(2-(5-(3,5-dichloro-4-fluorophenyl)-5- (Trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)(propane-2 -Alkyn-1-yl)carbamate (ethyl (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2 ,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)(prop-2-yn-1-yl)carbamate) (140 mg, 0.244 mmol, yield 37.1%). ¹ H-NMR (400 MHz, DMSO-D6) δ 8.57 (s, 1H), 7.80-7.77 (m, 3H), 4.72 (s, 4H), 4.50 (d, J = 2.4 Hz, 2H), 4.13- 3.91 (m, 4H), 3.25 (t, J = 2.3 Hz, 1H), 0.82 (t, J = 7.2 Hz, 3H). ESI MS (m/z) 572.40 (M-1).

Scheme 10 : Synthesis of pyrrolopyridine thioamide derivatives (thioamide derivative of pyrrolo pyridine)

step 1 : 2-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N-(3- Butyl methyl -2- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- Formamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) (32)

2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid (2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxylic acid)(0.35 g, 0.754 mmol), 3- To a stirred solution of methylbutan-2-amine (0.099 g, 1.131 mmol) and DIPEA (0.658 mL, 3.77 mmol) was added propanephosphonic acid anhydride (1.073 mL, 1.508 mmol). The resulting reaction mixture was heated to 25 °C and stirred for 2 hours. After completion of the reaction, the reaction mixture was quenched with water and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain crude material, which was purified by silica gel column chromatography to obtain 2-(5-(3,5-dichloro-4- Fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbut-2-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-(3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) (230 mg, 0.431 mmol, 57.2% yield). ¹ H-NMR (400 MHz, DMSO-D6) δ 8.63 (s, 1H), 8.36 (d, J = 9.2 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H) , 4.72 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.8 Hz, 1H), 3.84-3.79 (m, 1H), 1.80 (q, J = 6.7 Hz, 1H), 1.12 (d, J = 6.7 Hz, 3H), 0.86 (dd, J = 9.0, 6.9 Hz, 6H). ESI MS (m/z) 532.50 (M-1).

step 2 : 2-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N-(3- Butyl methyl -2- base )-2,3- Dihydro -1H- pyrrolo [3,4-c] pyridine -6- Thiocarbamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbothioamide) (33)

2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-N-(3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (0.230 g , 0.431 mmol) was added to the stirred solution of Lawesson reagent (0.349 g, 0.862 mmol). The reaction mixture was stirred at 105 °C for 16 hours. After completion of the reaction, the reaction mixture was cooled to 25 °C, diluted with water and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give crude material which was purified by preparative HPLC column chromatography to give 2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbut-2-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-thiocarbamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbothioamide) (135 mg, 0.246 mmol, yield rate of 57.0%). ¹ H-NMR (400 MHz, DMSO-D6) δ 10.48 (d, J = 8.9 Hz, 1H), 8.60 (s, 1H), 8.43 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H) , 4.73 (s, 4H), 4.51-4.46 (m, 1H), 4.05 (dd, J = 44.3, 17.1 Hz, 2H), 2.08-2.01 (m, 1H), 1.20 (d, J = 6.7 Hz, 3H ), 0.90 (dd, J = 11.9, 6.7 Hz, 6H). ESI MS (m/z) 549.05.

Step 11 : Synthesis of Thienopyrrole Thienoamide Derivatives (thioamide derivative of thieno pyrrole)

example 1 : N - Cyclopropyl -5-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-5,6- Dihydro -4H- Thieno [2,3-c] pyrrole -2- Thiocarbamide ( N -cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carbothioamide) (35) Synthesis

N -cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 in toluene (15 mL) at 25 °C ,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ( N -cyclopropyl-5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) (400 mg, 0.787 mmol) was added to a stirred solution of Lowe's reagent (637 mg, 1.57 mmol). The reaction mixture was stirred at 100 °C for 16 hours. After completion of the reaction, toluene was removed under reduced pressure, and the resulting reaction was quenched with water (15 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were washed with brine solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give crude material which was purified by prep-purification to give N -cyclopropyl as a solid -5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-thiocarbamide ( N -cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide) (234 mg, 0.446 mmol, 56.7% yield). ¹ H-NMR (400 MHz, DMSO-D6) δ 9.95 (d, J = 5.2 Hz, 1H), 7.75 (d, J = 6.1 Hz, 2H), 7.52 (s, 1H), 4.51 (d, J = 49.2 Hz, 4H), 4.01 (dd, J = 48.0, 17.1 Hz, 2H), 3.36-3.32 (m, 1H), 0.86-0.74 (m, 4H), ESI MS (m/z) 524 (M+1 ).

Scheme 12 : Synthesis of pyrrolo pyrimidine derivatives

step 1 : (E)-3-(( Dimethylamino ) methylene )-4- oxypyrrolidine -1- tert-butyl carboxylate (tert-butyl (E)-3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate) (37)

At 75 °C, tert-butyl 3-oxopyrrolidine-1-carboxylate (tert-butyl 3-oxopyrrolidine-1-carboxylate) (25 g, 135 mmol) and 1 , a solution of 1-dimethoxy- N , N -dimethylmethanamine (1,1-dimethoxy- N , N -dimethylmethanamine) (53.8 mL, 405 mmol) was stirred for 16 hours. After completion of the reaction, the reaction mixture was cooled to 25° C. and concentrated under reduced pressure to obtain crude material which was triturated with hexane. The resulting solid was filtered, washed with hexane and dried under reduced pressure to obtain (E)-3-((dimethylamino)methylene)-4-oxypyrrolidine-1-carboxylate as a solid tert-butyl (E)-3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (22 g, 92 mmol, 67.8% yield). ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 7.30 (s, 1H), 4.54 (d, J = 17.4 Hz, 2H), 3.83 (d, J = 19.6 Hz, 2H), 3.09 (s, 6H) , 1.49-1.45 (m, 9H). ESI MS (m/z) 240.55.

step 2 : 2-( Methylthio )-5,7- Dihydro -6H- pyrrolo [3,4-d] pyrimidine -6- tert-butyl carboxylate (tert-butyl 2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate) (38)

To a stirred solution of methylcarbamimidothioate sulfate (58.7 g, 312 mmol) in ethanol (335 mL) was added sodium ethoxide (21.24 g, 312 mmol) at 0 °C. mmol) and stirred for 10 minutes. (E)-tert-butyl 3-((dimethylamino)methylene)-4-oxypyrrolidine-1-carboxylate (25 g, 104 mmol) was added to the above solution. The resulting reaction mixture was heated at 75 °C for 16 hours. After completing the reaction, the reaction mixture was concentrated under reduced pressure. Water was added to the residue, and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain a crude product, which was purified by silica gel column chromatography to obtain 2-(methylthio)-5,7-di Hydrogen-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester (tert-butyl 2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine- 6-carboxylate) (16.5 g, 61.7 mmol, 59.3% yield). ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.42 (d, J = 18.1 Hz, 1H), 4.65-4.58 (m, 4H), 2.57 (d, J = 3.4 Hz, 3H), 1.51-1.48 ( m, 9H). ESI MS (m/z) 267.55.

step 3 : 2-( Methylthio )-6,7- Dihydro -5H- pyrrolo [3,4-d] pyrimidine (2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine) (39)

2-(Methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl in dichloromethane (26 mL) at 0 °C A stirred solution of the ester (13.00 g, 48.6 mmol) was added dropwise to a solution of trifluoroacetic acid (37.5 mL, 486 mmol) in dichloromethane (26 mL). The resulting reaction mixture was stirred at 25 °C for 4 hours. After completing the reaction, the reaction mixture was concentrated under reduced pressure to obtain a residue. Toluene:methanol (1:1) was added to the residue and concentrated under reduced pressure. Repeat the above process three times to obtain crude 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine (2-(methylthio)-6,7-dihydro- 5H-pyrrolo[3,4-d]pyrimidine), the 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine was used directly in the next step. ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.53 (d, J = 38.9 Hz, 1H), 4.72 (d, J = 11.7 Hz, 2H), 4.62 (s, 2H), 2.62-2.49 (m, 3H). ESI MS (m/z) 167.60.

step 4 : 5-(3,5- Dichlorophenyl )-3-(2-( Methylthio )-5,7- Dihydro -6H- pyrrolo [3,4-d] pyrimidine -6- base )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole (5-(3,5-dichlorophenyl)-3-(2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazole) (40)

To 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,2,2-trifluoroacetate (2-(methylthio)-6,7 -dihydro-5H-pyrrolo[3,4-d]pyrimidine 2,2,2-trifluoroacetate) (14 g, 49.8 mmol) was added to N -ethyldiisopropylamine ( 34.7 mL, 199 mmol) and 3-bromo-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (3-bromo -5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole) (15.17 g, 39.8 mmol). The resulting reaction mixture was stirred at 80 °C for 16 hours. After completing the reaction, the reaction mixture was concentrated under reduced pressure to obtain a crude product, which was purified by silica gel column chromatography to obtain 5-(3,5-dichlorophenyl)- 3-(2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-5-(trifluoromethyl)-4,5-di Hydroisoxazole ((5-(3,5-dichlorophenyl)-3-(2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-5- (trifluoromethyl)-4,5-dihydroisoxazole)) (12 g, 49.8 mmol, 51.6% yield). ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.46 (s, 1H), 7.58-7.56 (m, 2H), 4.65 (dd, J = 14.5, 13.8 Hz, 2H), 4.59 (t, J = 1.8 Hz, 2H), 3.86 (d, J = 16.1 Hz, 1H), 3.45 (d, J = 16.1 Hz, 1H), 2.58 (d, J = 5.1 Hz, 3H). ESI MS (m/z) 466.30 ( M-1).

step 5 : 5-(3,5- Dichlorophenyl )-3-(2-( Methylsulfonyl )-5,7- Dihydro -6H- pyrrolo [3,4-d] pyrimidine -6- base )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole (5-(3,5-dichlorophenyl)-3-(2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazole) (41)

5-(3,5-dichlorophenyl)-3-(2-(methylthio)-5,7-dihydro-6H-pyrrole in dichloromethane (120 mL) at 0 °C A stirred solution of [3,4-d]pyrimidin-6-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (11.8 g, 25.3 mmol) was added m-chloroperoxybenzoic acid (meta-Chloroperoxybenzoic acid, mCPBA) (12.07 g, 45.5 mmol). The resulting reaction mixture was stirred at 25 °C for 2 hours. After completion of the reaction, the reaction mixture was quenched with aqueous NaHCO ₃ and Na ₂ S ₂ O ₃ , and then extracted twice with dichloromethane. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give crude material which was triturated with hexane. The solid was filtered to obtain 5-(3,5-dichlorophenyl)-3-(2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4- d] pyrimidin-6-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (5-(3,5-dichlorophenyl)-3-(2-(methylsulfonyl)-5,7 -dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole) (10.30 g, 20.63 mmol, 82% yield). ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.85 (s, 1H), 7.57 (d, J = 6.1 Hz, 2H), 4.84-4.80 (m, 4H), 3.89 (d, J = 16.4 Hz, 1H), 3.49 (d, J = 16.1 Hz, 1H), 3.38 (d, J = 5.6 Hz, 3H). ESI MS (m/z) 498.30 (M-1).

step 6 : 6-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-6,7- Dihydro -5H- pyrrolo [3,4-d] pyrimidine -2- Formaldehyde (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d ]pyrimidine-2-carbonitrile) (42)

Add 5-(3,5-dichlorophenyl)-3-(2-(methylsulfonyl)-5,7-dihydro-6H-pyrrole in acetonitrile (100 mL) at 0 °C A stirred solution of [3,4-d]pyrimidin-6-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (12.0 g, 24.06 mmol) was added dropwise to acetonitrile (20 mL ) solution of tetrabutylammonium cyanide (7.75 g, 28.9 mmol). The resulting reaction mixture was stirred at 0 °C for 1 h. After completion of the reaction, the reaction mixture was quenched with water, and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain and purified by silica gel column chromatography to obtain 6-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carbonitrile (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d ]pyrimidine-2-carbonitrile) (8.80 g, 6.05 mmol, 80% yield). ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.80 (s, 1H), 7.57-7.52 (m, 2H), 4.82 (d, J = 2.2 Hz, 2H), 4.76 (d, J = 2.0 Hz, 2H), 3.89 (d, J = 16.1 Hz, 1H), 3.48 (d, J = 16.1 Hz, 1H). ESI MS (m/z) 445.85.

step 7 : 6-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-6,7- Dihydro -5H- pyrrolo [3,4-d] pyrimidine -2- carboxylic acid (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d ]pyrimidine-2-carboxylic acid) (43)

To a stirred solution of sodium hydroxide (7.18 g, 180 mmol) in water (136 mL) was added 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carbonitrile (8.8 g, 19.95 mmol). The resulting reaction mixture was stirred at 60 °C for 6 hours. After completion of the reaction, the reaction mixture was cooled to 25 °C and acidified with 10% HCl solution. The precipitate was filtered, washed twice with water and concentrated under reduced pressure to obtain 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-Dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxylic acid (6-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxylic acid) (8.20 g , 6.05 mmol, yield 80%). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 13.31-13.93 (1H), 8.93 (s, 1H), 7.77 (dd, J = 10.1, 6.4 Hz, 2H), 4.73-4.35 (m, 4H) , 4.16-3.98 (m, 2H). ESI MS (m/z) 464.55 (M+1).

step 8 : 6-(5-(3,5- Dichloro -4- Fluorophenyl )-5-( Trifluoromethyl )-4,5- Dihydroisoxazole -3- base )-N-(2,2- Difluoroethyl )-6,7- Dihydro -5H- pyrrolo [3,4-d] pyrimidine -2- Formamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-6,7-dihydro -5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) (44)

At 0 °C, to 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) A stirred solution of -6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxylic acid (0.250 g, 0.537 mmol) was added dropwise to N -ethyl acetate (4 mL) Diisopropylamine (0.282 mL, 1.612 mmol), 3,3-difluoroazetidine hydrochloride (3,3-difluoroazetidine hydrochloride) (0.104 g, 0.806 mmol) and 1-propanephosphonic acid cyclic anhydride ( 0.640 mL, 1.075 mmol). The resulting reaction mixture was stirred at 25 °C for 1 h. After completion of the reaction, the reaction mixture was diluted with water and extracted twice with dichloromethane. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain crude material, which was purified by preparative high performance liquid chromatography to give 6-(5-(3,5 -Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-6, 7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) (0.120 mg, 0.226 mmol, yield 42.0 %). ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.92 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.88 (t, J = 12.4 Hz, 2H), 4.73 (d, J = 5.2 Hz, 4H), 4.52 (t, J = 12.5 Hz, 2H), 4.08 (dd, J = 45.8, 17.1 Hz, 2H). ESI MS (m/z) 539.95.

Scheme 13 : Synthesis of Pyrrolo thiazol derivatives

The following compounds of the invention (Table 1) were obtained using methods similar to those described in the schemes above or in the Examples.

Table 1 Compound number Compound name analyze data 1 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.45 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.57 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.27-3.20 (m, 2H), 1.09 (t, J = 7.2 Hz , 3H); LCMS: 495.9+ 2 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.08 (t, J = 6.3 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.72 (s, 1H), 4.62 (s, 2H ), 4.49 (s, 2H), 4.09-4.01 (m, 3H), 3.95 (d, J = 16.8 Hz, 1H); LCMS:549.85 3 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(sulfur heterocyclic Butane-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.02 (d, J = 7.9 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.63 (s, 1H), 5.14 (td, J = 16.8, 8.7 Hz, 1H), 4.60 (s, 2H), 4.48 (s, 2H), 4.10-4.05 (m, 1H), 3.95 (d, J = 16.8 Hz, 1H), 3.49 (t, J = 9.2 Hz, 2H), 3.23 (td, J = 8.0, 1.2 Hz, 2H); LCMS:539.7 4 N-(cyclopropylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.55 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.62 (s, 1H), 4.60 (s, 2H ), 4.48 (s, 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.09 (t, J = 6.3 Hz, 2H), 1.02-0.95 (m , 1H), 0.44-0.40 (m, 2H), 0.22-0.18 (m, 2H) ; LCMS:521.75 5 N-(2-nitrile ethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2-cyanoethyl)-5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.84 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.61 (s, 1H), 4.61 (s, 2H ), 4.49 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 3.45 (q, J = 6.2 Hz, 2H), 2.76-2.72 (m , 2H); LCMS:521.05 6 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R) -2-Ethyl-3-oxyisoxazolin-4-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl) -5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.02 (d, J = 8.3 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.66 (s, 1H), 4.99 (q, J = 8.8 Hz, 1H), 4.61-4.55 (m, 3H), 4.49 (s, 2H), 4.09-3.93 (m, 3H), 3.60-3.45 (m, 2H), 1.14 (t, J = 7.2 Hz, 3H); LCMS: 580.7 7 N-cyclobutyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-cyclobutyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.59 (d, J = 7.6 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.63 (s, 1H), 4.59 (s, 2H ), 4.48 (s, 2H), 4.38-4.28 (m, 1H), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 2.22-2.15 (m, 2H) , 2.07-1.97 (m, 2H), 1.69-1.60 (m, 2H); LCMS:495.9 8 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.43 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.59 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.16 (q, J = 6.6 Hz, 2H), 1.50 (td, J = 14.5, 7.2 Hz, 2H), 0.86 (q, J = 7.2 Hz, 3H); LCMS:509.85 9 N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.44 (d, J = 4.0 Hz, 1H), 7.75 (d, J = 6.4 Hz, 2H), 7.56 (s, 1H), 4.59 (s, 2H ), 4.46 (s, 2H), 4.06 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 2.77 (qd, J = 7.4, 3.7 Hz, 1H), 0.68 (td , J = 7.0, 4.8 Hz, 2H), 0.55-0.51 (m, 2H); LCMS: 507.85 10 N-(tert-butyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(tert-butyl)-5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (d, J = 6.4 Hz, 3H), 7.68 (s, 1H), 4.58 (s, 2H), 4.46 (s, 2H), 4.07 (d , J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 1.32 (d, J = 13.8 Hz, 9H); LCMS:523.9 11 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.32 (t, J = 6.4 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.70 (s, 1H), 4.60 (s, 2H ), 4.48 (s, 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.05 (d, J = 6.7 Hz, 2H), 0.85 (d, J = 14.7 Hz, 9H); LCMS:537.9 12 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.22 (d, J = 7.8 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.63 (s, 1H), 4.53 (d, J = 47.2 Hz, 4H), 4.09-3.93 (m, 3H), 1.13 (d, J = 6.6 Hz, 6H); LCMS:510.7 13 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isobutyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.44 (t, J = 5.9 Hz, 1H), 7.75 (t, J = 5.7 Hz, 2H), 7.63 (d, J = 7.3 Hz, 1H), 4.66-4.47 (m, 4H), 4.07 (d, J = 16.9 Hz, 1H), 3.97-3.88 (m, 1H), 3.03 (t, J = 6.4 Hz, 2H), 1.84-1.74 (m, 1H) , 0.86 (d, J = 6.8 Hz, 6H); LCMS:523.9 14 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-isopropoxy-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 11.46 (s, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.52 (s, 1H), 4.54 (d, J = 55.3 Hz, 4H ), 4.12-4.05 (m, 2H), 3.95 (d, J = 16.9 Hz, 1H), 1.22-1.17 (m, 6H); LCMS:528.05 15 N-(1-cyclopropylethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyclopropylethyl)-5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.33 (d, J = 8.3 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.66 (s, 1H), 4.54 (d, J = 46.5 Hz, 4H), 4.08 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 16.9 Hz, 1H), 3.38 (dd, J = 14.9, 8.1 Hz, 1H), 1.19 (d, J = 6.8 Hz, 3H), 0.96-0.91 (m, 1H), 0.45-0.41 (m, 1H), 0.39-0.33 (m, 1H), 0.28-0.23 (m, 1H), 0.20-0.15 (m, 1H );LCMS:536.05 16 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(propan-2 -yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.94 (t, J = 5.5 Hz, 1H), 7.79-7.75 (m, 2H), 7.62 (s, 1H), 4.54 (d, J = 49.6 Hz , 4H), 4.09-3.93 (m, 4H), 3.15 (t, J = 2.6 Hz, 1H); LCMS:506.25 17 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.43 (q, J = 4.3 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.54 (s, 1H), 4.53 (d, J = 49.4 Hz, 4H), 4.06 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 2.74 (d, J = 4.6 Hz, 3H); LCMS: 506.25 18 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( Methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.61 (t, J = 5.6 Hz, 1H), 7.77-7.74 (m, 2H), 7.58 (s, 1H), 4.54 (d, J = 48.4 Hz , 4H), 4.07 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.40 (dd, J = 13.6, 6.2 Hz, 2H), 2.60 (q, J = 7.1 Hz , 2H), 2.06 (d, J = 13.7 Hz, 3H); LCMS:541.7 19 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl Cyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.64 (s, 1H), 7.75 (d, J = 6.1 Hz, 2H), 7.55 (s, 1H), 4.58 (s, 2H), 4.45 (s , 2H), 4.06 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 1.34 (d, J = 5.9 Hz, 3H), 0.71-0.65 (m, 2H), 0.64 -0.57 (m, 2H); LCMS:521.95 20 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methyl Oxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.53 (t, J = 5.3 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.62 (s, 1H), 4.60 (s, 2H ), 4.47 (s, 2H), 4.01 (dd, J = 46.9, 17.0 Hz, 2H), 3.44-3.41 (m, 2H), 3.39-3.34 (m, 2H), 3.25 (s, 3H); LCMS: 525.6 twenty one 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( Trifluoromethyl)cyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(trifluoromethyl)cyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.16 (s, 1H), 7.75 (d, J = 6.4 Hz, 2H), 7.70 (d, J = 11.6 Hz, 1H), 4.60 (s, 2H ), 4.47 (s, 2H), 4.09-4.05 (m, 1H), 3.95 (d, J = 17.1 Hz, 1H), 1.36-1.25 (m, 2H), 1.19-1.11 (m, 2H); LCMS: 575.85 twenty two 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxoheterocycle Butane-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.10 (d, J = 6.6 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.69 (s, 1H), 4.95 (td, J = 13.8, 6.7 Hz, 1H), 4.75 (t, J = 7.0 Hz, 2H), 4.60 (s, 2H), 4.55 (t, J = 6.5 Hz, 2H), 4.49 (s, 2H), 4.07 (d , J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H); LCMS: 523.75 twenty three 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran- 2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.55 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.64 (d, J = 8.6 Hz, 1H), 4.59 (s, 2H), 4.47 (s, 2H), 4.09-4.03 (m, 1H), 3.97-3.85 (m, 2H), 3.80-3.73 (m, 1H), 3.61 (dd, J = 14.3, 7.5 Hz, 1H), 3.26 (t, J = 5.9 Hz, 2H), 1.92-1.74 (m, 3H), 1.58-1.50 (m, 1H); LCMS:551.7 twenty four N-cyclopentyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopentyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.26 (d, J = 7.1 Hz, 1H), 7.77-7.74 (m, 2H), 7.65 (d, J = 3.9 Hz, 1H), 4.59 (s , 2H), 4.47 (s, 2H), 4.17-4.05 (m, 2H), 3.95 (d, J = 16.9 Hz, 1H), 1.87-1.82 (m, 2H), 1.71-1.63 (m, 2H), 1.56-1.44 (m, 4H); LCMS:535.75 25 N-cyclohexyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-cyclohexyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.19 (d, J = 7.8 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.65 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.67 (t, J = 3.5 Hz, 1H), 1.89-1.70 (m , 4H), 1.59 (d, J = 12.0 Hz, 1H), 1.32-1.22 (m, 4H), 1.14-1.06 (m, 1H); LCMS:549.85 26 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro -2H-pyran-4-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.47 (t, J = 5.9 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.62 (s, 1H), 4.53 (d, J = 48.9 Hz, 4H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.85-3.81 (m, 2H), 3.24 (dd, J = 11.6, 9.9 Hz , 2H), 3.10 (t, J = 6.2 Hz, 2H), 1.79-1.68 (m, 1H), 1.56 (d, J = 12.7 Hz, 2H), 1.16 (ddd, J = 24.8, 12.0, 4.3 Hz, 2H); LCMS:566.1 27 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isoamyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.40 (t, J = 5.6 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.58 (s, 1H), 4.53 (d, J = 48.9 Hz, 4H), 4.09-4.01 (m, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.22 (dd, J = 13.9, 6.4 Hz, 2H), 1.64-1.54 (m, 1H) , 1.41-1.32 (m, 2H), 0.92-0.87 (m, 6H); LCMS:538.85 28 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiazole-2 -ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.39 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.72 (d, J = 3.2 Hz, 1H), 7.67 (s, 1H), 7.62 (d, J = 3.4 Hz, 1H), 4.71 (d, J = 6.1 Hz, 2H), 4.55 (d, J = 49.6 Hz, 4H), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H); LCMS:565.5 29 N-(cyclopentylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopentylmethyl)-5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.45 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.61 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.97-3.93 (m, 1H), 3.15-3.11 (m, 2H), 2.13-2.06 (m, 1H), 1.68- 1.43 (m, 6H), 1.21 (dt, J = 18.5, 6.5 Hz, 2H); LCMS:549.95 30 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro -2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.52 (t, J = 5.7 Hz, 1H), 7.77-7.74 (m, 2H), 7.64 (d, J = 9.3 Hz, 1H), 4.59 (s , 2H), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.88-3.82 (m, 1H), 3.40-3.34 (m, 1H), 3.28-3.15 (m, 3H), 1.76 (d, J = 3.4 Hz, 1H), 1.57 (d, J = 12.7 Hz, 1H), 1.46-1.39 (m, 3H), 1.22-1.09 (m , 1H); LCMS:565.5 31 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2,2,2-Trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.57 (t, J = 6.2 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.61 (s, 2H), 4.43 (d, J = 17.9 Hz, 2H), 4.09-3.94 (m, 4H), 2.31 (s, 3H); LCMS:563.9 32 (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H- Thieno[2,3-c]pyrrol-2-yl)(3,3-difluoroazetidin-1-yl)methanone ((5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3,3-difluoroazetidin-1-yl)methanone ) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 7.43 (s, 1H), 4.97-4.48 (m , 8H), 4.09 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H); LCMS:525.7 33 N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.44 (d, J = 3.9 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 7.56 (s, 1H), 4.59 (s, 2H), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 2.77 (qd, J = 7.4, 3.6 Hz, 1H), 0.68 (td, J = 7.1, 4.7 Hz, 2H), 0.55-0.51 (m, 2H); LCMS:491.05 34 N-(1-cyanocyclopropyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclopropyl)-5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.33 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.59-7.58 (m, 3H), 4.62 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 1.55 (dd, J = 8.2, 5.5 Hz, 2H), 1.25 (dd, J = 8.2, 5.5 Hz, 2H); LCMS: 515.8 35 N-(1-cyclopropylethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyclopropylethyl)-5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.32 (d, J = 8.3 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.66 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 3.43-3.35 (m , 1H), 1.22-1.13 (m, 3H), 0.99-0.90 (m, 1H), 0.47-0.41 (m, 1H), 0.39-0.32 (m, 1H), 0.26 (td, J = 9.2, 5.1 Hz , 1H), 0.17 (td, J = 9.2, 5.0 Hz, 1H); LCMS:518.35 36 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-ethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.45 (t, J = 5.5 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58-7.57 (m, 3H), 4.60 (s , 2H), 4.48 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 3.27-3.20 (m, 2H), 1.09 (t, J = 7.2 Hz, 3H); LCMS:478.25 37 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio) Ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.60 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (s, 3H), 4.60 (s, 2H ), 4.48 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.40 (dd, J = 13.3, 6.2 Hz, 2H), 2.61 (t , J = 7.0 Hz, 2H), 2.08 (s, 3H); LCMS: 523.95 38 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.53 (t, J = 5.5 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.62 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 3.44-3.35 (m , 4H), 3.25 (s, 3H); LCMS:508.35 39 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.93 (t, J = 5.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.62 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.61 (s, 2H), 4.48 (s, 2H), 4.10-3.92 (m, 4H), 3.14 (t, J = 2.4 Hz, 1H); LCMS:488.25 40 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isobutyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.44 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.63 (s, 1H), 7.58 (d, J = 2.0 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 3.03 (t, J = 6.4 Hz, 2H), 1.78 (td, J = 13.6, 6.8 Hz, 1H), 0.86 (d, J = 6.6 Hz, 6H); LCMS:506.35 41 N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.20 (t, J = 5.5 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.63 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.62 (s, 2H), 4.49 (s, 2H), 4.30 (d, J = 5.6 Hz, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H); LCMS:488.95 42 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.41 (t, J = 5.7 Hz, 1H), 7.75 (t, J = 1.8 Hz, 1H), 7.59-7.58 (m, 3H), 4.60 (s , 2H), 4.48 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.17 (q, J = 6.6 Hz, 2H), 1.50 (td , J = 14.4, 7.2 Hz, 2H), 0.87 (t, J = 7.5 Hz, 3H); LCMS:493.05 43 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.5 Hz, 2H), 7.55 (s, 1H ), 4.59 (s, 2H), 4.46 (s, 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 1.33 (s, 3H), 0.72-0.69 (m, 2H), 0.64-0.57 (m, 2H); LCMS: 505.1 44 N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.54 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.62 (s, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 3.09 (t, J = 6.3 Hz, 2H), 1.02-0.95 (m, 1H), 0.44-0.40 (m, 2H), 0.22-0.18 (m, 2H); LCMS:505.05 45 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.32 (t, J = 6.4 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.70 (s, 1H), 7.59 (d, J = 1.8 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.05 (d, J = 6.7 Hz, 2H), 0.87 (s, 9H); LCMS:521.3 46 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy-5,6 -Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3- yl)-N-isopropoxy-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 11.40 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 7.52 (s, 1H ), 4.61 (s, 2H), 4.47 (s, 2H), 4.12-4.09 (m, 1H), 4.07-4.03 (m, 1H), 3.94 (d, J = 17.1 Hz, 1H), 1.18 (dd, J = 20.9, 14.8 Hz, 6H); LCMS: 509.15 47 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.21 (d, J = 7.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.63 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.59 (s, 2H), 4.48 (s, 2H), 4.10-3.92 (m, 3H), 1.13 (d, J = 6.6 Hz, 6H); LCMS:493.0 48 N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5, 6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (q, J = 2.0 Hz, 2H), 7.68 (s, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.94 (d, J = 16.8 Hz, 1H), 1.34 (s, 9H); LCMS:507.2 49 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-tri Fluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.09 (t, J = 6.4 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.72 (s, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.62 (s, 2H), 4.50 (s, 2H), 4.10-4.01 (m, 3H), 3.95 (d, J = 17.1 Hz, 1H); LCMS:533.0 50 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.42 (q, J = 4.3 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 7.53 (s, 1H), 4.60 (s, 2H), 4.47 (s, 2H), 4.09-4.05 (m, 1H), 3.94 (d, J = 17.1 Hz, 1H), 2.73 (t, J = 4.9 Hz , 3H); LCMS:463.8 51 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.75 (q, J = 4.7 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 2.81 (d, J = 4.9 Hz, 3H); LCMS:458.85 52 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-tri Fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.33 (t, J = 6.7 Hz, 1H), 8.70 (s, 1H), 8.11 (s, 1H), 7.78 (t, J = 2.0 Hz, 1H ), 7.62 (d, J = 1.7 Hz, 2H), 4.76 (s, 4H), 4.15-3.99 (m, 4H); LCMS:526.90 53 N-(cyclopropylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopropylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.81 (t, J = 6.0 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 2.0 Hz, 2H), 4.73 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.16 (t, J = 6.6 Hz, 2H), 1.09-1.02 (m, 1H), 0.43-0.38 (m, 2H), 0.25-0.22 (m, 2H); LCMS:498.90 54 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.12 (t, J = 6.0 Hz, 1H), 8.64 (s, 1H), 8.05 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.13-4.01 (m, 4H), 3.07 (t, J = 2.4 Hz, 1H); LCMS:483.05 55 N-(cyclobutylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclobutylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.73 (t, J = 6.2 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.75 (d, J = 21.5 Hz, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 3.33 (d, J = 6.6 Hz, 2H), 2.55 (q, J = 7.4 Hz, 1H), 1.99-1.91 (m, 2H), 1.84-1.77 (m, 2H), 1.74-1.65 (m, 2H) ;LCMS:512.95 56 N-(cyclopentylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopentylmethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.75 (t, J = 6.2 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.22 (t, J = 6.7 Hz, 2H), 2.20-2.13 (m, 1H), 1.67-1.42 (m, 6H), 1.29-1.19 (m, 2H); LCMS:527.00 57 N-(1-cyanocyclobutyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclobutyl)-2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.65 (s, 1H), 8.67 (s, 1H), 8.05 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d , J = 1.7 Hz, 2H), 4.74 (s, 4H), 4.12 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 2.69-2.63 (m, 2H), 2.59 -2.51 (m, 2H), 2.08-1.96 (m, 2H); LCMS:523.95 58 N-(1-cyanocyclopentyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopentyl)-2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.13 (s, 1H), 8.66 (d, J = 0.6 Hz, 1H), 8.07 (d, J = 0.6 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.60 (d, J = 1.8 Hz, 2H), 4.74 (s, 4H), 4.12 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 2.32-2.29 (m, 4H), 1.78-1.71 (m, 4H); LCMS:537.95 59 N-(cyclobutylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5, 6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclobutylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.42 (t, J = 5.8 Hz, 1H), 7.78-7.75 (m, 1H), 7.64-7.60 (m, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.60 (s, 2H), 4.44 (d, J = 28.7 Hz, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.24 (t, J = 6.4 Hz, 2H), 2.46 (t, J = 7.2 Hz, 1H), 2.00-1.92 (m, 2H), 1.87-1.76 (m, 2H), 1.72-1.63 (m, 2H); LCMS:518.0 60 N-(cyclopentylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopentylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.44 (t, J = 5.8 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.65-7.61 (m, 1H), 7.58 (d , J = 1.8 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.94 (d, J = 16.8 Hz, 1H), 3.13 (dd , J = 6.9, 6.0 Hz, 2H), 2.15-2.04 (m, 1H), 1.69-1.60 (m, 2H), 1.59-1.43 (m, 4H), 1.22 (dt, J = 18.5, 6.6 Hz, 2H );LCMS:532.0 61 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl base)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.86 (t, J = 6.0 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.67 (s, 1H), 7.58 (d, J = 1.8 Hz, 2H), 6.09 (tt, J = 55.8, 3.9 Hz, 1H), 4.61 (s, 2H), 4.49 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d , J = 17.1 Hz, 1H), 3.63 (tdd, J = 15.8, 5.8, 4.1 Hz, 2H); LCMS:513.85 62 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3 ,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.07 (t, J = 6.3 Hz, 1H), 7.77 (t, J = 1.8 Hz, 1H), 7.72 (s, 1H), 7.59 (d, J = 1.8 Hz, 2H), 4.62 (s, 2H), 4.50 (s, 2H), 4.15-4.06 (m, 3H), 3.95 (d, J = 16.8 Hz, 1H); LCMS:581.9 63 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-tri Fluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.84 (d, J = 8.6 Hz, 1H), 7.77 (q, J = 1.8 Hz, 2H), 7.59 (d, J = 1.8 Hz, 2H), 4.77 (dt, J = 23.1, 7.5 Hz, 1H), 4.62 (s, 2H), 4.50-4.42 (m, 2H), 4.09 (dd, J = 17.0, 1.4 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 1.34 (d, J = 7.0 Hz, 3H); LCMS:545.9 64 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethane Base-3-oxyisoxazolidin-4-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-5,6-dihydro-4H -thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.02 (d, J = 8.3 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.66 (s, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.99 (q, J = 9.0 Hz, 1H), 4.62-4.55 (m, 3H), 4.50 (s, 2H), 4.10-4.01 (m, 2H), 3.95 (d, J = 16.8 Hz, 1H), 3.58-3.47 (m, 2H), 1.14 (t, J = 7.0 Hz, 3H); LCMS:562.9 65 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(1,1,1-trifluoroprop-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1,1,1-trifluoropropan-2-yl)-5,6 -dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.50 (d, J = 8.9 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.76 (td, J = 15.6, 7.6 Hz, 1H ), 4.61 (s, 2H), 4.45 (s, 2H), 4.10-4.06 (m, 1H), 3.97 (d, J = 17.1 Hz, 1H), 2.30 (d, J = 11.9 Hz, 3H), 1.32 (d, J = 7.3 Hz, 3H); LCMS: 577.25 66 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -Difluoroethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.28 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 6.09 (tt, J = 56.1, 4.0 Hz, 1H ), 4.60 (s, 2H), 4.45 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.60 (tdd, J = 15.5, 5.7, 4.2 Hz, 2H), 2.31 (s, 3H); LCMS:546.0 67 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3 -Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.92 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.59 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H), 3.24-3.17 (m, 2H), 2.27 (d, J = 15.0 Hz, 3H), 1.08 (t , J = 7.2 Hz, 3H); LCMS:509.4 68 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-propyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.76 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.24 (dd, J = 13.9, 6.4 Hz, 2H), 1.53 (td, J = 14.5, 7.3 Hz, 2H), 0.86 (t, J = 7.5 Hz, 3H); LCMS:487.10 69 N-(cyanomethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyanomethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.45 (t, J = 6.0 Hz, 1H), 8.67 (s, 1H), 8.09 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.74 (s, 4H), 4.29 (d, J = 5.9 Hz, 2H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H); LCMS:484.0 70 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thietane-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.45 (d, J = 8.6 Hz, 1H), 8.66 (d, J = 9.0 Hz, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d, J = 1.5 Hz, 2H), 5.24 (td, J = 17.5, 8.7 Hz, 1H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H ), 3.98 (d, J = 16.9 Hz, 1H), 3.66 (t, J = 9.2 Hz, 2H), 3.17 (t, J = 8.6 Hz, 2H); LCMS:516.95 71 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-ethyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.78 (t, J = 6.0 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.6 Hz, 2H), 4.72 (s, 4H), 4.13-4.07 (m, 1H), 3.98 (d, J = 17.1 Hz, 1H), 3.34-3.30 (m, 2H) , 1.11 (t, J = 7.1 Hz, 3H); LCMS:472.75 72 N-cyclopropyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclopropyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.71 (d, J = 5.1 Hz, 1H), 8.60 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.71 (s, 4H), 4.04 (dd, J = 43.3, 17.1 Hz, 2H), 2.90 (td, J = 11.4, 4.8 Hz, 1H), 0.71-0.66 (m, 4H); LCMS:502.7 73 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(sulfur heterocyclic Butane-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thietan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.45 (d, J = 8.6 Hz, 1H), 8.65 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 5.24 (dd, J = 17.2, 8.9 Hz, 1H), 4.72 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.66 (t , J = 9.0 Hz, 2H), 3.17 (t, J = 8.6 Hz, 2H); LCMS:535.0 74 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,3,3,3-pentafluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.28 (t, J = 6.7 Hz, 1H), 8.68 (s, 1H), 8.09 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.74 (s, 4H), 4.18-3.98 (m, 4H); LCMS:594.30 75 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,3,3,3-pentafluoropropyl)-5, 6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.56 (s, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.61 (s, 2H), 4.45 (s, 2H), 4.09-3.94 (m, 4H), 2.29 (d, J = 14.1 Hz, 3H); LCMS:613.2 76 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethane Base-3-oxyisoxazolidin-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2,3-dihydro-1H -pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.26 (d, J = 8.6 Hz, 1H), 8.67 (s, 1H), 8.06 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 5.05 (dd, J = 19.0, 8.7 Hz, 1H), 4.74 (s, 4H), 4.55 (t, J = 8.6 Hz, 1H), 4.20 (dd , J = 10.8, 8.1 Hz, 1H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.60-3.46 (m, 2H), 1.19-1.11 (m, 3H); LCMS: 558.50 77 N-(2-cyanobut-2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanobutan-2-yl)-2-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.78 (s, 1H), 8.66 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.74 (s , 4H), 4.11 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H), 2.13 (dt, J = 21.2, 7.4 Hz, 1H), 1.98 (dt, J = 21.0, 7.4 Hz, 1H), 1.67 (s, 3H), 0.99 (t, J = 7.5 Hz, 3H); LCMS:543.45 78 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl) Methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.65-8.62 (m, 2H), 8.04 (s, 1H), 7.76 (t, J = 1.7 Hz, 1H), 7.60 (d, J = 1.2 Hz , 2H), 4.72 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.01-3.95 (m, 2H), 3.77 (q, J = 7.1 Hz, 1H), 3.62 (q, J = 7.3 Hz, 1H), 3.42-3.32 (m, 2H), 1.92-1.75 (m, 3H), 1.61-1.53 (m, 1H); LCMS:529.0 79 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoroethyl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(2-fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.91 (t, J = 6.0 Hz, 1H), 8.64 (s, 1H), 8.05 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.60 (t, J = 5.1 Hz, 1H), 4.49 (t, J = 5.3 Hz, 1H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.60 (dq, J = 25.5, 5.5 Hz, 2H); LCMS:491.0 80 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pent-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(pentan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.62 (s, 1H), 8.30 (d, J = 9.3 Hz, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.5 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.80-3.74 (m , 1H), 1.59-1.46 (m, 4H), 0.82 (t, J = 7.5 Hz, 6H); LCMS:515.05 81 N-allyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-allyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.90 (t, J = 6.1 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 5.93-5.84 (m, 1H), 5.15-5.04 (m, 2H), 4.73 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H) , 3.99 (d, J = 16.9 Hz, 1H), 3.93-3.90 (m, 2H); LCMS:484.45 82 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3 -Difluorocyclobutyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-difluorocyclobutyl)-3-methyl-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.36 (d, J = 6.6 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.60 (s, 2H), 4.45 (s, 2H ), 4.23-4.15 (m, 1H), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.95-2.85 (m, 2H), 2.79-2.65 (m, 2H), 2.30 (s, 3H); LCMS:572.0 83 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl- 3-Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.94 (t, J = 5.8 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.01 (t, J = 6.4 Hz, 2H), 2.27 (d, J = 15.0 Hz, 3H), 1.85-1.75 (m, 1H), 0.86 (d, J = 6.7 Hz, 6H); LCMS:538.25 84 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -Neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.89 (t, J = 6.3 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.08 (d, J = 17.1 Hz, 1H), 3.97 (d, J = 17.1 Hz, 1H), 3.03 (d, J = 6.7 Hz, 2H), 2.30 (s, 3H), 0.87 (s, 9H ); LCMS:552.2 85 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H), 3.38 (dd, J = 13.8, 6.1 Hz, 2H), 2.61 (t, J = 7.0 Hz, 2H ), 2.30 (s, 3H), 2.07 (s, 3H); LCMS:556.15 86 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.38 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.60 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.98-3.94 (m, 3H), 3.10 (t, J = 2.3 Hz, 1H), 2.30 (s, 3H); LCMS:520.25 87 N-(tert-butyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(tert-butyl)-5-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.75 (d, J = 6.4 Hz, 2H), 7.33 (s, 1H), 4.50 (d, J = 60.6 Hz, 4H), 4.02 (dd, J = 44.1, 17.0 Hz, 2H), 2.25 (s, 3H), 1.33 (s, 9H); LCMS:538.25 88 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -Propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.91 (t, J = 5.6 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.59 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.14 (q, J = 6.7 Hz, 2H), 2.28 (s, 3H), 1.49 (td, J = 14.4, 7.3 Hz, 2H), 0.86 (t, J = 7.5 Hz, 3H); LCMS:524.2 89 N-((1-cyanocyclopropyl)methyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-((1-cyanocyclopropyl)methyl)-5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.88 (t, J = 6.1 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.68 (s, 1H), 4.61 (s, 2H ), 4.50 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.38 (d, J = 5.9 Hz, 2H), 1.23-1.16 (m , 2H), 1.14-1.08 (m, 2H); LCMS:547.0 90 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2- Oxy-2-((2,2,2)-trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-formyl Amine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2 ,2-trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.81 (t, J = 6.0 Hz, 1H), 8.61 (t, J = 6.4 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.65 (s, 1H), 4.61 (s, 2H), 4.49 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.98-3.86 (m, 5H); LCMS:606.95 91 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2-oxyl-2-((2,2,2-trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-Formamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-oxo -2-((2,2,2-trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.58 (t, J = 6.5 Hz, 1H), 8.10 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.60 (s, 2H), 4.45 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.98-3.86 (m, 5H), 2.33 (s, 3H); LCMS:621.0 92 N-(1-cyanocyclobutyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclobutyl)-2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.65 (s, 1H), 8.67 (s, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.74 (s , 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H), 2.68-2.53 (m, 4H), 2.03 (t, J = 8.4 Hz, 2H); LCMS :541.95 93 N-(1-cyanocyclopentyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopentyl)-2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.12 (s, 1H), 8.66 (s, 1H), 8.07 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.73 (s , 4H), 4.11 (d, J = 16.8 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 2.30 (t, J = 7.2 Hz, 4H), 1.78-1.71 (m, 4H); LCMS :555.95 94 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxoheterocycle Butane-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.45 (d, J = 7.1 Hz, 1H), 8.66 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 5.03 (q, J = 7.3 Hz, 1H), 4.73-4.66 (m, 8H), 4.10 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H); LCMS:519.0 95 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophene-2 -ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.36 (t, J = 6.4 Hz, 1H), 8.63 (d, J = 0.6 Hz, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 7.35 (dd, J = 5.0, 1.4 Hz, 1H), 7.00 (q, J = 1.5 Hz, 1H), 6.93 (dd, J = 5.2, 3.4 Hz, 1H), 4.72 (s , 4H), 4.63 (d, J = 6.1 Hz, 2H), 4.10 (d, J = 16.8 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H); LCMS:559.0 96 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R) -2-Ethyl-3-oxyisoxazolidin-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.26 (d, J = 8.3 Hz, 1H), 8.67 (d, J = 4.9 Hz, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 5.05 (q, J = 9.4 Hz, 1H), 4.73 (s, 4H), 4.55 (t, J = 8.6 Hz, 1H), 4.20 (dd, J = 10.6, 7.9 Hz, 1H ), 4.12-4.08 (m, 1H), 4.00 (d, J = 16.9 Hz, 1H), 3.58-3.46 (m, 2H), 1.14 (t, J = 7.1 Hz, 3H); LCMS:575.35 97 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2- Oxy-2-((2,2,2)-trifluoroethyl)amino)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formyl Amine (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2 ,2-trifluoroethyl)amino)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.94 (t, J = 6.0 Hz, 1H), 8.66 (s, 1H), 8.62 (t, J = 6.5 Hz, 1H), 8.05 (s, 1H ), 7.78 (d, J = 6.4 Hz, 2H), 4.73 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.02-3.87 (m, 5H); LCMS:601.35 98 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxoheterocycle Butane-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.03 (t, J = 6.1 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.62-4.58 (m, 2H), 4.34 (t, J = 6.1 Hz, 2H), 4.10 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.8 Hz , 1H), 3.56 (t, J = 6.4 Hz, 2H), 3.21-3.14 (m, 1H); LCMS:533.0 99 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isoamyl-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.39 (t, J = 5.6 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.7 Hz, 3H), 4.60 (s, 2H), 4.47 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.22 (dd, J = 13.9, 6.4 Hz, 2H ), 1.64-1.54 (m, 1H), 1.38 (q, J = 7.2 Hz, 2H), 0.88 (d, J = 6.8 Hz, 6H); LCMS:520.0 100 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyridine Fyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.51 (t, J = 5.9 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.65 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.10-4.01 (m, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.85 (dd, J = 10.9, 2.1 Hz, 1H), 3.40-3.34 (m, 2H), 3.28-3.15 (m, 2H), 1.75 (s, 1H), 1.57 (d, J = 12.7 Hz, 1H), 1.41 (d, J = 18.1 Hz, 3H), 1.18-1.10 (m, 1H); LCMS:548.0 101 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyridine Fyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.51 (t, J = 5.9 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.65 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.10-4.01 (m, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.85 (dd, J = 10.9, 2.1 Hz, 1H), 3.40-3.34 (m, 2H), 3.28-3.15 (m, 2H), 1.75 (s, 1H), 1.57 (d, J = 12.7 Hz, 1H), 1.41 (d, J = 18.1 Hz, 3H), 1.18-1.10 (m, 1H); LCMS:532.0 102 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.11 (d, J = 8.6 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.69 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (dd, J = 17.0, 2.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.75 (dt , J = 22.1, 6.9 Hz, 1H), 1.71 (td, J = 13.6, 6.7 Hz, 1H), 1.07 (d, J = 6.6 Hz, 3H), 0.86 (q, J = 3.3 Hz, 6H); LCMS :520.0 103 5-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(thietan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.02 (d, J = 7.8 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.63 (s, 1H), 7.58 (d, J = 1.5 Hz, 2H), 5.14 (td, J = 16.8, 8.4 Hz, 1H), 4.60 (s, 2H), 4.49 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d , J = 16.9 Hz, 1H), 3.49 (t, J = 9.2 Hz, 2H), 3.25-3.21 (m, 2H); LCMS:521.95 104 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyl Butyl-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.36 (d, J = 9.2 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.8 Hz, 1H), 3.84-3.79 (m, 1H), 1.80 (q, J = 6.7 Hz , 1H), 1.12 (d, J = 6.7 Hz, 3H), 0.86 (dd, J = 9.0, 6.9 Hz, 6H); LCMS:533.05 105 N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyanomethyl)-5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.59 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.61 (s, 2H), 4.46 (s, 2H ), 4.22 (d, J = 5.6 Hz, 2H), 4.09-4.03 (m, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.31 (d, J = 15.4 Hz, 3H); LCMS:520.95 106 N-(cyclopropylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.99 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 16.9 Hz, 1H), 3.07 (t, J = 6.2 Hz, 2H), 2.29-2.27 (m, 3H), 1.06-0.97 (m, 1H), 0.43-0.38 (m, 2H), 0.22-0.18 (m, 2H); LCMS:536.0 107 N-(2-cyanoethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanoethyl)-2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.11 (t, J = 6.1 Hz, 1H), 8.66 (s, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.73 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.54 (q, J = 6.4 Hz, 2H), 2.81-2.75 (m , 2H); LCMS:516.55 108 N-cyclopentyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopentyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.26 (d, J = 7.3 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.65 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.59 (s, 2H), 4.48 (s, 2H), 4.17-4.06 (m, 2H), 3.94 (d, J = 17.1 Hz, 1H), 1.88-1.82 (m, 2H) , 1.68-1.62 (m, 2H), 1.56-1.44 (m, 4H); LCMS:518.0 109 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(5-methylhexyl-2 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(5-methylhexan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.14 (d, J = 8.3 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.64 (s, 1H), 7.58 (d, J = 1.5 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (dd, J = 16.9, 1.7 Hz, 1H), 3.97-3.85 (m, 2H), 1.52-1.39 (m, 3H), 1.22-1.10 (m, 5H), 0.84-0.80 (m, 6H); LCMS:548.05 110 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbutyl) -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-N-(2-methylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.40 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.62 (s, 1H), 7.58 (d, J = 2.0 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.17-3.11 (m , 1H), 3.01 (dt, J = 13.0, 5.7 Hz, 1H), 1.59 (dt, J = 19.5, 6.8 Hz, 1H), 1.43-1.33 (m, 1H), 1.14-1.04 (m, 1H), 0.89-0.83 (m, 6H); LCMS:520.0 111 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2, 2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.57 (t, J = 6.2 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.61 (s, 2H), 4.46 (s, 2H), 4.10-3.94 (m, 4H), 2.31 (s, 3H); LCMS:545.95 112 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2- (Methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylthio)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (t, J = 5.7 Hz, 1H), 7.77 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.38 (dd, J = 13.6, 6.3 Hz, 2H ), 2.63-2.58 (m, 2H), 2.30 (s, 3H), 2.07 (d, J = 5.8 Hz, 3H); LCMS:537.95 113 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(propane- 2-Alkyn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(prop-2-yn-1-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.39 (t, J = 5.5 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.60 (s, 2H), 4.45 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.97-3.93 (m, 3H), 3.11 (t, J = 2.4 Hz, 1H), 2.30 (s , 3H); LCMS:502.85 114 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.93 (t, J = 5.5 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 3.43-3.40 (m, 2H), 3.35 (t , J = 5.3 Hz, 2H), 3.25 (s, 3H), 2.29 (s, 3H); LCMS:522.15 115 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3-methyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-ethyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.93 (t, J = 5.5 Hz, 1H), 7.77 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.24-3.17 (m, 2H), 2.28 (s , 3H), 1.08 (t, J = 7.2 Hz, 3H); LCMS:492.2 116 N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 3-Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopropylmethyl)-5-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (t, J = 5.8 Hz, 1H), 7.77 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.5 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.07 (t, J = 6.3 Hz, 2H), 2.29-2.27 (m, 3H), 1.03-0.97 (m, 1H), 0.43-0.38 (m, 2H), 0.20 (td, J = 5.3, 3.9 Hz, 2H); LCMS:518.1 117 N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3- Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(tert-butyl)-5-(5-(3,5-dichlorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.77 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 7.35 (s, 1H), 4.58 (s, 2H ), 4.43 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.25 (s, 3H), 1.33 (s, 9H); LCMS:520.25 118 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.94 (t, J = 5.8 Hz, 1H), 7.77 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.01 (t, J = 6.4 Hz, 2H), 2.29 (s, 3H), 1.83-1.77 (m, 1H), 0.86 (d, J = 6.7 Hz, 6H); LCMS:520.2 119 N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-cyclopropyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (d, J = 4.0 Hz, 1H), 7.78-7.76 (m, 1H), 7.58 (d, J = 1.5 Hz, 2H), 4.58 (s , 2H), 4.43 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 2.75 (qd, J = 7.4, 3.7 Hz, 1H), 2.26 (s, 3H), 0.70-0.61 (m, 2H), 0.59-0.48 (m, 2H); LCMS:504.15 120 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methyl Oxyethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.91 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 16.9 Hz, 1H), 3.43-3.40 (m, 2H), 3.35 (q, J = 5.4 Hz, 2H), 3.25 (s , 3H), 2.29 (s, 3H); LCMS:540.2 121 N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3 -Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyanomethyl)-5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.59 (t, J = 5.4 Hz, 1H), 7.76 (s, 1H), 7.58 (s, 2H), 4.61 (s, 2H), 4.46 (s , 2H), 4.22 (d, J = 5.4 Hz, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 2.33 (s, 3H); LCMS:503.3 122 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-propyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-3-methyl-N-propyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.92 (t, J = 5.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.08 (d, J = 17.1 Hz, 1H), 3.93 (t, J = 17.1 Hz, 1H), 3.84-3.80 (m, 1H), 3.14 (q, J = 6.6 Hz, 2H), 2.28 (s , 3H), 1.49 (td, J = 14.5, 7.2 Hz, 2H), 0.86 (t, J = 7.5 Hz, 3H); LCMS:506.2 123 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxyl-2 -((2,2,2-Trifluoroethyl)amino))ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2- (5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.94 (t, J = 6.0 Hz, 1H), 8.66 (s, 1H), 8.62 (t, J = 6.2 Hz, 1H), 8.05 (s, 1H ), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d, J = 1.7 Hz, 2H), 4.74 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 4.01-3.87 (m , 5H); LCMS:584.30 124 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-neopentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.64 (s, 1H), 8.56 (t, J = 6.6 Hz, 1H), 8.05 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.15 (d, J = 6.8 Hz, 2H), 0.88 (s, 9H); LCMS:515.0 125 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(1-methylcyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.82 (s, 1H), 8.58 (s, 1H), 8.01 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.60 (d , J = 1.7 Hz, 2H), 4.71 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.98 (d, J = 16.9 Hz, 1H), 1.35 (s, 3H), 0.78-0.75 (m, 2H), 0.61 (dd, J = 6.7, 4.8 Hz, 2H); LCMS: 126 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N,3-dimethyl Base-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N,3-dimethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.85 (q, J = 4.4 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.58 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.71 (d, J = 4.6 Hz, 3H), 2.29 (s, 3H); LCMS:495.85 127 N-(1-cyanocyclopropyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopropyl)-2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.71 (s, 1H), 8.64 (s, 1H), 8.07 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.60 (d , J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 1.55-1.48 (m, 2H), 1.38 -1.30 (m, 2H); LCMS:510.10 128 N-cyclopropyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclopropyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.71 (d, J = 5.1 Hz, 1H), 8.60 (s, 1H), 8.02 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 2.90 (td, J = 11.5, 4.7 Hz, 1H), 0.71-0.66 (m, 4H); LCMS:485.20 129 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isobutyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.74 (t, J = 6.2 Hz, 1H), 8.63 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.12 (t, J = 6.6 Hz, 2H), 1.91-1.81 (m, 1H), 0.86 (d, J = 6.6 Hz, 6H); LCMS:501.20 130 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.67 (d, J = 6.1 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.46 (d, J = 2.7 Hz, 4H), 3.25 (s, 3H); LCMS:503.0 131 N-cyclobutyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclobutyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.90 (d, J = 8.3 Hz, 1H), 8.63 (s, 1H), 8.01 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.44 (q, J = 8.4 Hz, 1H), 4.11 (d, J = 17.1 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 2.19-2.13 (m, 4H), 1.68-1.60 (m, 2H); LCMS:498.95 132 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N,3-dimethyl-5, 6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-N,3-dimethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.84 (q, J = 4.4 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58-7.55 (m, 2H), 4.51 (d , J = 59.9 Hz, 4H), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 2.71 (d, J = 4.6 Hz, 3H), 2.33-2.25 (m , 3H); LCMS:478.75 133 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-neopentyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.89 (t, J = 6.4 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.5 Hz, 2H), 4.52 (d, J = 58.1 Hz, 4H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.03 (d, J = 6.4 Hz, 2H), 2.30 ( s, 3H), 0.87 (s, 9H); LCMS:534.25 134 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-2,3- Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-N-isopropyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.61 (s, 1H), 8.44 (d, J = 8.3 Hz, 1H), 8.03 (s, 1H), 7.76 (s, 1H), 7.60 (s , 2H), 4.72 (s, 4H), 4.15-4.06 (m, 2H), 3.98 (d, J = 16.9 Hz, 1H), 1.18 (d, J = 6.6 Hz, 6H); LCMS:487.0 135 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio) Ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.88 (t, J = 6.0 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.49 (dd, J = 13.7, 6.4 Hz, 2H), 2.65 (t, J = 7.0 Hz, 2H), 2.08 (s, 3H); LCMS:518.90 136 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3 ,3-pentafluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.28 (t, J = 6.7 Hz, 1H), 8.68 (s, 1H), 8.09 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.74 (s, 4H), 4.18-4.09 (m, 3H), 3.99 (d, J = 17.1 Hz, 1H); LCMS:576.35 137 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-tri Fluoroprop-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.12 (d, J = 9.3 Hz, 1H), 8.67 (s, 1H), 8.08 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.86-4.74 (m, 5H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 1.39 (d , J = 7.1 Hz, 3H); LCMS:540.40 138 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-difluorocyclo Butyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(3,3-difluorocyclobutyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.29 (d, J = 7.6 Hz, 1H), 8.65 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.38-4.27 (m, 1H), 4.11 (d, J = 17.1 Hz, 1H), 3.98 (d, J = 17.1 Hz , 1H), 2.93-2.84 (m, 4H); LCMS:535.40 139 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,3,3,3-pentafluoropropyl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.07 (t, J = 6.4 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.72 (s, 1H), 4.55 (d, J = 49.2 Hz, 4H), 4.15-4.05 (m, 3H), 3.96 (d, J = 16.8 Hz, 1H); LCMS:599.25 140 N-(1-cyanocyclobutyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclobutyl)-5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.27 (s, 1H), 7.78 (dd, J = 14.8, 5.7 Hz, 2H), 7.71 (d, J = 8.3 Hz, 1H), 4.56 (d , J = 49.8 Hz, 4H), 4.08 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H), 2.68-2.61 (m, 2H), 2.46-2.41 (m, 2H) , 2.11-1.96 (m, 2H); LCMS:546.4 141 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( 4-methylthiazol-5-yl)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(4-methylthiazol-5-yl)ethyl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.80 (s, 1H), 8.63 (t, J = 5.8 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.55 (s, 1H ), 4.54 (d, J = 49.2 Hz, 4H), 4.06 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 3.41-3.35 (m, 2H), 2.99 (t , J = 6.9 Hz, 2H), 2.33-2.29 (m, 3H); LCMS:592.3 142 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-pentyl-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-pentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.43 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.59 (s, 1H), 4.67-4.40 (m , 4H), 4.09-4.01 (m, 1H), 3.95 (d, J = 16.8 Hz, 1H), 3.19 (q, J = 6.6 Hz, 2H), 1.52-1.45 (m, 2H), 1.34-1.19 ( m, 4H), 0.90-0.80 (m, 3H); LCMS:537.35 143 N-(1-cyanocyclohexyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclohexyl)-5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.59 (s, 1H), 7.76 (t, J = 3.1 Hz, 3H), 4.62 (s, 2H), 4.49 (s, 2H), 4.08 (d , J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.29 (d, J = 13.2 Hz, 2H), 1.77-1.69 (m, 4H), 1.60-1.44 (m, 3H) , 1.28 (dd, J = 23.2, 11.0 Hz, 1H); LCMS:575.5 144 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -Difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.85 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.67 (s, 1H), 6.09 (tt, J = 55.9, 3.9 Hz, 1H), 4.61 (s, 2H), 4.49 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.68-3.58 (m, 2H); LCMS: 530.35 145 N-(cyclobutylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclobutylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.42 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.60 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 3.24 (t, J = 6.4 Hz, 2H), 2.46 (t, J = 7.5 Hz, 1H), 2.00-1.92 (m, 2H), 1.84-1.77 (m, 2H), 1.72-1.63 (m, 2H); LCMS:536.45 146 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R) -2-Ethyl-3-oxyisoxazolin-4-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-formyl Amine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((R)-2-ethyl-3-oxoisoxazolidin -4-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.46 (d, J = 8.3 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.96 (dd, J = 18.8, 8.8 Hz, 1H ), 4.61-4.53 (m, 3H), 4.45 (s, 2H), 4.09-4.03 (m, 2H), 3.96 (d, J = 16.6 Hz, 1H), 3.57-3.46 (m, 2H), 2.31 ( s, 3H), 1.13 (t, J = 7.1 Hz, 3H); LCMS:594.3 147 5-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thiophene And[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6- dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.93 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (t, J = 1.8 Hz, 3H), 7.40 (s, 1H ), 4.60 (s, 2H), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H); LCMS:449.0 148 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl base)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.06 (t, J = 6.2 Hz, 1H), 8.66 (s, 1H), 8.07 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 6.13 (tt, J = 56.0, 4.1 Hz, 1H), 4.73 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d , J = 17.1 Hz, 1H), 3.75-3.65 (m, 2H); LCMS:508.85 149 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridin-2-ylmethyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(pyridin-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.37 (t, J = 6.0 Hz, 1H), 8.68 (s, 1H), 8.52 (dq, J = 4.9, 0.9 Hz, 1H), 8.10 (d , J = 19.6 Hz, 1H), 7.77-7.60 (m, 4H), 7.31-7.25 (m, 2H), 4.74-4.61 (m, 6H), 4.06 (dd, J = 49.2, 17.1 Hz, 2H); LCMS:535.90 150 N-((1-cyanocyclopropyl)methyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-((1-cyanocyclopropyl)methyl)-2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.17 (t, J = 6.6 Hz, 1H), 8.68 (s, 1H), 8.08 (s, 1H), 7.77 (t, J = 1.8 Hz, 1H ), 7.61 (d, J = 1.7 Hz, 2H), 4.74 (s, 4H), 4.06 (dd, J = 49.5, 17.0 Hz, 2H), 3.45 (d, J = 6.4 Hz, 2H), 1.23-1.14 (m, 4H); LCMS:523.90 151 N-(tert-butyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2, 3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(tert-butyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.60 (d, J = 7.8 Hz, 1H), 8.01 (t, J = 6.7 Hz, 2H), 7.77 (t, J = 1.8 Hz, 1H), 7.61-7.59 (m, 2H), 4.76 (d, J = 28.4 Hz, 4H), 4.06 (dd, J = 49.4, 16.9 Hz, 2H), 1.41-1.23 (m, 9H); LCMS:500.95 152 N-(2-nitrile ethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanoethyl)-2-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.10 (t, J = 6.2 Hz, 1H), 8.65 (d, J = 2.9 Hz, 1H), 8.06 (d, J = 3.9 Hz, 1H), 7.76 (q, J = 1.7 Hz, 1H), 7.61-7.54 (m, 2H), 4.73 (s, 4H), 4.05 (dd, J = 49.5, 17.0 Hz, 2H), 3.54 (q, J = 6.4 Hz , 2H), 2.84-2.77 (m, 2H); LCMS:497.45 153 N-butyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-butyl-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.74 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 3.28 (q, J = 6.8 Hz, 2H), 1.54-1.47 (m, 2H), 1.29 (td, J = 14.8, 7.4 Hz, 2H), 0.88 (t, J = 7.5 Hz, 3H); LCMS:500.90 154 (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone ) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.62 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.59 (d, J = 1.7 Hz, 2H ), 4.98 (t, J = 12.3 Hz, 2H), 4.72 (s, 4H), 4.50 (t, J = 12.7 Hz, 2H), 4.04 (dd, J = 48.5, 17.0 Hz, 2H); LCMS:520.35 155 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl base)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.69 (d, J = 7.6 Hz, 1H), 8.65 (s, 1H), 8.02 (s, 1H), 7.74 (t, J = 1.8 Hz, 1H ), 7.58-7.56 (m, 2H), 4.94-4.87 (m, 1H), 4.71 (s, 4H), 4.45-4.37 (m, 4H), 4.10-3.94 (m, 2H); LCMS:631.25 156 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl base)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.59 (d, J = 7.3 Hz, 1H), 8.64 (s, 1H), 8.01 (s, 1H), 7.73 (t, J = 1.8 Hz, 1H ), 7.57 (d, J = 1.7 Hz, 2H), 7.12 (t, J = 52.3 Hz, 1H), 4.87-4.70 (m, 5H), 4.34-4.23 (m, 4H), 4.09-3.93 (m, 2H); LCMS:613.25 157 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3 -Dimethylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.38 (t, J = 5.6 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.56 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.06 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.25-3.19 (m, 2H), 1.44-1.40 (m, 2H) , 0.90 (s, 9H); LCMS:552.45 158 N-Butyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5 ,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-butyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.41 (t, J = 5.6 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.59 (s, 1H), 4.59 (s, 2H ), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 3.20 (dd, J = 12.7, 6.8 Hz, 2H), 1.50-1.43 (m, 2H), 1.35-1.25 (m, 2H), 0.88 (t, J = 7.3 Hz, 3H); LCMS:524.4 159 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro -4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.93 (s, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.59 (s, 1H), 7.40 (s, 1H), 4.59 (s , 2H), 4.47 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H); LCMS:467.4 160 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( (Trifluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.13 (d, J = 7.3 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.64 (s, 1H), 4.87-4.78 (m , 1H), 4.61 (s, 2H), 4.47 (t, J = 8.1 Hz, 4H), 4.29 (t, J = 6.9 Hz, 2H), 4.10-4.05 (m, 1H), 3.96 (d, J = 16.8 Hz, 1H); LCMS:654.8 161 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 ,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.84 (d, J = 8.6 Hz, 1H), 7.78-7.75 (m, 3H), 4.76 (td, J = 15.5, 7.5 Hz, 1H), 4.61 (s, 2H), 4.49 (s, 2H), 4.08 (dd, J = 17.0, 1.4 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 1.34 (d, J = 7.0 Hz, 3H) ;LCMS:563.85 162 N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyanomethyl)-5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.20 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.63 (s, 1H), 4.62 (s, 2H ), 4.49 (s, 2H), 4.30 (d, J = 5.5 Hz, 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H); LCMS:508.8 163 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl Base-2,5-dioxypyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-5,6- dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (d, J = 4.0 Hz, 1H), 7.75 (d, J = 6.1 Hz, 2H), 4.58 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.75 (qd, J = 7.4, 3.7 Hz, 1H), 2.26 (s, 3H), 0.66 (td , J = 7.2, 4.6 Hz, 2H), 0.54-0.51 (m, 2H); LCMS:578.8 164 N-allyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-allyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.66 (t, J = 5.9 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.63 (s, 1H), 7.58 (d, J = 2.0 Hz, 2H), 5.91-5.81 (m, 1H), 5.15 (dq, J = 17.3, 1.8 Hz, 1H), 5.08 (dq, J = 10.3, 1.5 Hz, 1H), 4.60 (s, 2H) , 4.48 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 3.86-3.84 (m, 2H); LCMS:489.85 165 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.12 (t, J = 5.9 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.62 (s, 1H), 7.58 (d, J = 2.0 Hz, 2H), 7.38 (dd, J = 5.1, 1.2 Hz, 1H), 7.00 (dd, J = 3.3, 1.1 Hz, 1H), 6.95 (dd, J = 5.1, 3.4 Hz, 1H), 4.59 (t, J = 5.9 Hz, 4H), 4.48 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H); LCMS:545.35 166 N-(2-cyclopentylethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2-cyclopentylethyl)-5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.41 (t, J = 5.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 3H), 4.60 (s, 2H), 4.47 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.21 (dd, J = 13.8, 6.2 Hz, 2H ), 1.79-1.71 (m, 3H), 1.60-1.43 (m, 6H), 1.09-1.06 (m, 2H); LCMS:545.45 167 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoroethyl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(2-fluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.70 (t, J = 5.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.64 (s, 1H), 7.58 (d, J = 2.0 Hz, 2H), 4.61-4.55 (m, 3H), 4.49-4.43 (m, 3H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.52 (dq, J = 26.9, 5.2 Hz, 2H); LCMS: 495.4 168 N-butyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-di Hydrogen-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-butyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol- 3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.41 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 2.4 Hz, 3H), 4.60 (s, 2H), 4.47 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 3.20 (dd, J = 12.7, 6.8 Hz, 2H ), 1.50-1.43 (m, 2H), 1.35-1.25 (m, 2H), 0.88 (t, J = 7.3 Hz, 3H); LCMS:505.4 169 N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6- Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.59 (d, J = 7.8 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.63 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.60 (s, 2H), 4.48 (s, 2H), 4.33 (td, J = 16.2, 8.2 Hz, 1H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d , J = 17.1 Hz, 1H), 2.22-2.15 (m, 2H), 2.07-1.97 (m, 2H), 1.71-1.60 (m, 2H); LCMS:503.4 170 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1 ,3,4-oxadiazol-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-5,6- dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.21 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.65 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.62 (d, J = 5.9 Hz, 4H), 4.49 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 2.46 (s, 3H); LCMS:546.35 171 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl base)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.11 (d, J = 6.8 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.66 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 7.15 (t, J = 52.3 Hz, 1H), 4.76 (td, J = 14.4, 6.4 Hz, 1H), 4.61 (s, 2H), 4.50 (s, 2H), 4.33 (t , J = 8.1 Hz, 2H), 4.21-4.17 (m, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H); LCMS:619.5 172 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxyl-2 -((2,2,2-Trifluoroethyl)amino)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl) -5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.81 (t, J = 6.0 Hz, 1H), 8.61 (t, J = 6.4 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.65 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.64 (d, J = 23.2 Hz, 2H), 4.50 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.97-3.86 (m, 5H); LCMS:589.4 173 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl) Methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.84 (t, J = 5.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.61 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 5.74 (s, 1H), 4.61 (s, 2H), 4.49 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H ), 3.45 (q, J = 6.2 Hz, 2H), 2.75 (t, J = 6.4 Hz, 2H); LCMS:533.95 174 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxoheterocycle Butane-3-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetan-3-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.58 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.59 (s, 1H), 4.61 (dd, J = 7.8, 6.1 Hz, 4H), 4.47 (s, 2H), 4.31 (t, J = 6.0 Hz, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H ), 3.49 (t, J = 6.4 Hz, 2H), 3.15-3.08 (m, 1H); LCMS:557.2 175 N-(1-cyanocyclopropyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclopropyl)-5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (d, J = 4.0 Hz, 1H), 7.75 (d, J = 6.1 Hz, 2H), 4.58 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.75 (qd, J = 7.4, 3.7 Hz, 1H), 2.26 (s, 3H), 0.66 (td , J = 7.2, 4.6 Hz, 2H), 0.54-0.51 (m, 2H); LCMS:532.85 176 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2, 5-Dioxypyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.14 (d, J = 7.8 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58-7.56 (m, 3H), 4.62 (dd , J = 12.5, 9.0 Hz, 3H), 4.49 (s, 2H), 4.08 (q, J = 5.6 Hz, 1H), 3.94 (d, J = 16.9 Hz, 1H), 3.16 (d, J = 5.4 Hz , 0H), 3.01 (dd, J = 17.6, 9.3 Hz, 1H), 2.87 (s, 3H), 2.63 (dd, J = 17.7, 5.0 Hz, 1H); LCMS:560.9 177 N-(2-nitrile ethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2-cyanoethyl)-5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.84 (t, J = 5.5 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d, J = 10.3 Hz, 3H), 4.61 (s, 2H), 4.49 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.45 (q, J = 6.2 Hz, 2H), 2.75 (t, J = 6.4 Hz, 2H); LCMS: 502.9 178 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pent-2-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-N-(pentan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.39 (t, J = 5.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 3H), 4.59 (s, 2H), 4.47 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.94 (d, J = 17.1 Hz, 1H), 3.22 (dd, J = 13.9, 6.1 Hz, 2H ), 1.64-1.54 (m, 1H), 1.38 (q, J = 7.1 Hz, 2H), 0.89-0.84 (m, 6H); LCMS:519.45 179 5-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(oxetane-3 -yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(oxetan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.10 (d, J = 6.6 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.69 (s, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.95 (td, J = 13.9, 6.7 Hz, 1H), 4.75 (t, J = 7.0 Hz, 2H), 4.61 (s, 2H), 4.55 (t, J = 6.5 Hz, 2H ), 4.50 (s, 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H); LCMS:505.4 180 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-methoxy-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 11.74 (s, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.48 (s, 1H), 4.54 (d, J = 56.5 Hz, 4H ), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.72-3.65 (m, 3H); LCMS:497.8 181 Azetidin-1-yl(5-(5-(3,5-dichloro-4-fluorophenyl))-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)methanone (azetidin-1-yl(5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)methanone) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.77-7.72 (m, 2H), 7.32 (d, J = 15.0 Hz, 1H), 4.53 (d, J = 59.0 Hz, 6H), 4.17-3.93 (m, 4H), 2.33-2.26 (m, 2H); LCMS:507.85 182 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophene-2 -ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.12 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.63 (t, J = 6.9 Hz, 1H), 7.41-7.36 (m, 1H), 7.00 (q, J = 1.5 Hz, 1H), 6.95 (dd, J = 5.2, 3.4 Hz, 1H), 4.59 (t, J = 5.5 Hz, 4H), 4.47-4.41 (m, 2H), 4.09-4.05 (m, 1H), 3.95 (d, J = 17.1 Hz, 1H); LCMS:563.8 183 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( (Difluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-5 ,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.16-9.10 (m, 1H), 7.82-7.71 (m, 2H), 7.69-7.61 (m, 1H), 7.29-6.99 (m, 1H), 4.76 (td, J = 14.4, 6.6 Hz, 1H), 4.55 (d, J = 44.3 Hz, 4H), 4.39-4.27 (m, 2H), 4.25-4.13 (m, 2H), 4.07 (d, J = 16.8 Hz, 1H), 4.01-3.93 (m, 1H); LCMS:636.75 184 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5- Methyl-1,3,4-oxadiazol-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl )methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.21 (t, J = 5.8 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.65 (s, 1H), 4.62 (d, J = 5.8 Hz, 4H), 4.49 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 2.88 (s, 1H), 2.72 (d, J = 0.6 Hz, 1H), 2.46 (d, J = 4.0 Hz, 3H); LCMS:563.85 185 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.32 (t, J = 6.7 Hz, 1H), 8.68 (s, 1H), 8.09 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.73 (s, 4H), 4.13-3.98 (m, 4H); LCMS:544.40 186 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyl Oxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyloxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.27 (s, 1H), 8.64 (s, 1H), 8.01 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.72 (d , J = 6.4 Hz, 6H), 4.35 (d, J = 6.6 Hz, 2H), 4.10 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.4 Hz, 1H), 1.59 (s, 3H );LCMS:532.40 187 N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.81 (t, J = 6.1 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H), 3.16 (t, J = 6.5 Hz, 2H), 1.09-1.01 (m , 1H), 0.43-0.38 (m, 2H), 0.25-0.22 (m, 2H); LCMS:516.40 188 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(propan-2 -Alkyn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.12 (t, J = 6.0 Hz, 1H), 8.64 (d, J = 0.7 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.73 (s, 4H), 4.12-3.97 (m, 4H), 3.07 (t, J = 2.4 Hz, 1H); LCMS:500.40 189 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methyl Oxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methoxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.68 (d, J = 5.4 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.46 (t, J = 1.5 Hz, 4H), 3.25 (s, 3H );LCMS:520.45 190 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.75 (q, J = 4.7 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 2.81 (d, J = 4.9 Hz, 3H); LCMS:476.45 191 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( (Difluoromethyl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-2 ,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.62 (d, J = 7.3 Hz, 1H), 8.67 (d, J = 0.6 Hz, 1H), 8.05 (d, J = 0.6 Hz, 1H), 7.78 (d, J = 6.4 Hz, 2H), 7.15 (t, J = 52.4 Hz, 1H), 4.91-4.81 (m, 1H), 4.73 (s, 4H), 4.36 (t, J = 7.2 Hz, 2H ), 4.29 (t, J = 8.1 Hz, 2H), 4.12-4.07 (m, 1H), 3.99 (d, J = 17.1 Hz, 1H); LCMS:631.25 192 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isobutyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.74 (t, J = 6.1 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.12 (t, J = 6.6 Hz, 2H), 1.91-1.81 (m , 1H), 0.89-0.85 (m, 6H); LCMS:518.45 193 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2, 5-dioxypyrrolidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.45 (d, J = 8.6 Hz, 1H), 8.66 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.92-4.86 (m, 1H), 4.73 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz , 1H), 3.00 (dd, J = 17.4, 9.3 Hz, 1H), 2.86 (s, 3H), 2.66-2.60 (m, 1H); LCMS:555.95 194 N-(1-cyclopropylethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyclopropylethyl)-2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.58 (d, J = 8.8 Hz, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.40 (td, J = 15.4, 6.6 Hz, 1H), 1.23 (d, J = 6.6 Hz, 3H), 1.13-1.04 (m, 1H), 0.48-0.42 (m, 1H), 0.38-0.32 (m, 1H), 0.28- 0.17 (m, 2H); LCMS:512.95 195 N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.01 (d, J = 4.0 Hz, 1H), 7.75 (d, J = 6.1 Hz, 2H), 4.58 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.75 (qd, J = 7.4, 3.7 Hz, 1H), 2.26 (s, 3H), 0.66 (td , J = 7.2, 4.6 Hz, 2H), 0.54-0.51 (m, 2H); LCMS:521.85 196 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy- 3-Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 11.26 (s, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.07 (d , J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.66 (s, 3H), 2.29 (s, 3H); LCMS:511.85 197 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(1-methyl-2,5-dioxypyrrolidinyl)-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ( 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methyl-2,5-dioxopyrrolidin -3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.51 (d, J = 7.9 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.66-4.61 (m, 3H), 4.45 (s , 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H), 2.98 (q, J = 8.9 Hz, 1H), 2.86 (s, 3H), 2.60 (dd , J = 17.4, 5.2 Hz, 1H), 2.30 (s, 3H); LCMS:502.9 198 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-formyl Amine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-((trifluoromethyl)sulfonyl )azetidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.69 (d, J = 7.0 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.84-4.77 (m, 1H), 4.61 (s , 2H), 4.42 (q, J = 7.6 Hz, 4H), 4.30 (t, J = 6.9 Hz, 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H ), 2.32 (s, 3H); LCMS:668.85 199 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxypropane- 2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxypropan-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (t, J = 2.0 Hz, 1H), 7.70 (d, J = 8.1 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.13-4.06 (m, 2H), 3.96 (d, J = 17.1 Hz, 1H), 3.37 (dd, J = 9.5, 6.4 Hz, 1H), 3.25 (dd, J = 8.9, 6.5 Hz, 4H), 2.27 (s, 3H), 1.13-1.09 (m, 3H); LCMS:536.45 200 N-cyclopentyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-cyclopentyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.83 (d, J = 7.3 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.15-4.06 (m, 2H), 3.95 (d, J = 17.1 Hz, 1H), 2.26 (s, 3H), 1.87-1.80 (m, 2H) , 1.71-1.62 (m, 2H), 1.54-1.45 (m, 4H); LCMS:531.95 201 (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6- Dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3,3-difluoroazetidin-1-yl)methanone ((5-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)(3, 3-difluoroazetidin-1-yl)methanone) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.62-4.53 (m, 6H), 4.46 (s , 2H), 4.08 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 2.30 (s, 3H); LCMS:539.9 202 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropoxy-3-methanol Base-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-isopropoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 10.99 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.60 (s, 2H ), 4.45 (s, 2H), 4.10-3.93 (m, 3H), 2.28 (s, 3H), 1.22-1.16 (m, 6H); LCMS:521.9 203 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1- Methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.14 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.58 (s, 2H ), 4.43 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 2.25 (s, 3H), 1.33 (s, 3H), 0.71-0.65 (m, 2H), 0.62-0.55 (m, 2H); LCMS:517.9 204 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1, 1,1-trifluoroprop-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.51 (d, J = 8.9 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.76 (td, J = 15.5, 7.5 Hz, 1H), 4.61 (s, 2H), 4.46 (s, 2H), 4.09 (d, J = 17.4 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H ), 2.28 (s, 3H), 1.32 (d, J = 7.0 Hz, 3H); LCMS:559.9 205 N-(1-cyclopropylethyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyclopropylethyl)-5-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.84 (d, J = 8.6 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 16.8 Hz, 1H), 3.37 (td, J = 15.2, 6.8 Hz, 1H ), 2.28 (s, 3H), 1.18 (d, J = 6.7 Hz, 3H), 1.01-0.92 (m, 1H), 0.47-0.40 (m, 1H), 0.39-0.32 (m, 1H), 0.27 ( td, J = 9.2, 5.1 Hz, 1H), 0.17 (td, J = 9.2, 5.2 Hz, 1H); LCMS:531.95 206 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiazole- 2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.83 (t, J = 5.8 Hz, 1H), 7.77 (t, J = 1.8 Hz, 1H), 7.72 (d, J = 3.4 Hz, 1H), 7.62 (d, J = 3.4 Hz, 1H), 7.59 (d, J = 1.8 Hz, 2H), 4.68 (d, J = 6.1 Hz, 2H), 4.61 (s, 2H), 4.46 (s, 2H), 4.10-4.06 (m, 1H), 3.96 (d, J = 16.8 Hz, 1H), 2.34 (s, 3H); LCMS:560.85 207 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl Base)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.28 (t, J = 6.0 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 6.09 (tt, J = 56.0, 4.0 Hz, 1H), 4.61 (s, 2H), 4.45 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H ), 3.60 (tdd, J = 15.6, 5.8, 4.2 Hz, 2H), 2.31 (s, 3H); LCMS:527.85 208 N-(1-cyanocyclopropyl)-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclopropyl)-5-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.88 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.61 (s, 2H ), 4.45 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 2.30 (s, 3H), 1.52 (dd, J = 8.2, 5.5 Hz , 2H), 1.24 (dd, J = 8.2, 5.7 Hz, 2H); LCMS:528.9 209 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy-3-methyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-N-methoxy-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 11.26 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.8 Hz, 2H), 4.60 (s, 2H ), 4.45 (s, 2H), 4.08 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.67 (s, 3H), 2.29 (s, 3H); LCMS:493.9 210 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiazol-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.83 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.72 (d, J = 3.4 Hz, 1H), 7.62 (d, J = 3.4 Hz, 1H), 4.68 (d, J = 5.8 Hz, 2H), 4.61 (s, 2H), 4.46 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.97 (d, J = 17.1 Hz, 1H), 2.33 (d, J = 9.2 Hz, 3H); LCMS:578.45 211 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3 -Dimethylbut-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutan-2-yl)-3-methyl-5,6-dihydro- 4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (d, J = 6.1 Hz, 2H), 7.57 (d, J = 9.2 Hz, 1H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.08 (dd, J = 17.0, 2.0 Hz, 1H), 3.97 (d, J = 17.1 Hz, 1H), 3.91-3.85 (m, 1H), 2.28 (s, 3H), 1.05 (d, J = 6.7 Hz, 3H), 0.89 (d, J = 15.0 Hz, 9H); LCMS:565.6 212 N-(cyclopentylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclopentylmethyl)-5-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.95 (t, J = 5.8 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.58 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.12 (dd, J = 7.0, 5.8 Hz, 2H), 2.30 (d, J = 15.0 Hz, 3H ), 2.10 (td, J = 14.7, 7.4 Hz, 1H), 1.68-1.43 (m, 6H), 1.26-1.18 (m, 2H); LCMS:565.55 213 N-(2-(cyclopropylamino)-2-oxyethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-(cyclopropylamino)-2-oxoethyl)- 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.76 (t, J = 5.7 Hz, 1H), 8.63 (s, 1H), 8.02 (t, J = 4.0 Hz, 2H), 7.74 (t, J = 1.8 Hz, 1H), 7.57 (d, J = 1.8 Hz, 2H), 4.70 (s, 4H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.83 (d, J = 5.8 Hz, 2H), 2.63-2.57 (m, 1H), 0.58 (td, J = 7.0, 4.9 Hz, 2H), 0.39-0.35 (m, 2H); LCMS:541.90 214 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(isobutylamine Base)-2-oxylethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(isobutylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.81 (t, J = 5.8 Hz, 1H), 8.63 (s, 1H), 8.02-7.90 (m, 2H), 7.74-7.57 (m, 3H) , 4.70 (s, 4H), 4.11-3.88 (m, 4H), 2.87 (t, J = 6.3 Hz, 2H), 1.70-1.60 (m, 1H), 0.96-0.79 (m, 6H); LCMS:557.95 215 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methylcyclopropyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.13 (s, 1H), 7.75 (d, J = 6.4 Hz, 2H), 4.57 (s, 2H), 4.42 (s, 2H), 4.06 (d , J = 16.9 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 2.25 (s, 3H), 1.33 (s, 3H), 0.71-0.68 (m, 2H), 0.62-0.55 (m, 2H); LCMS:535.85 216 N-((1-cyanocyclopropyl)methyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-((1-cyanocyclopropyl)methyl )-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.37 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.61 (s, 2H), 4.46 (s, 2H ), 4.08 (d, J = 17.1 Hz, 1H), 3.97 (d, J = 17.1 Hz, 1H), 3.35 (d, J = 6.1 Hz, 2H), 2.32 (s, 3H), 1.22-1.13 (m , 2H), 1.08 (dd, J = 7.5, 5.0 Hz, 2H); LCMS:560.9 217 N-(cyclobutylmethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(cyclobutylmethyl)-5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.92 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.58 (s, 2H), 4.43 (s, 2H ), 4.01 (dd, J = 43.4, 17.0 Hz, 2H), 3.23-3.20 (m, 2H), 2.53-2.51 (m, 1H), 2.27 (s, 3H), 1.99-1.90 (m, 2H), 1.83-1.75 (m, 2H), 1.73-1.64 (m, 2H); LCMS:550.0 218 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(pent-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(pentan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (d, J = 6.4 Hz, 2H), 7.58 (d, J = 8.8 Hz, 1H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.08 (d, J = 16.9 Hz, 1H), 3.97 (d, J = 17.1 Hz, 1H), 3.70-3.65 (m, 1H), 2.27 (s, 3H), 1.56-1.37 (m, 4H) , 0.88-0.82 (m, 6H); LCMS:552.0 219 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( Isobutylamino)-2-oxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(isobutylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.83 (t, J = 5.7 Hz, 1H), 8.66 (s, 1H), 8.05 (s, 1H), 7.93 (t, J = 5.7 Hz, 1H ), 7.78 (d, J = 6.4 Hz, 2H), 4.73 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.02-3.85 (m, 3H), 2.90 (t, J = 6.4 Hz , 2H), 1.71-1.64 (m, 1H), 0.83 (d, J = 6.6 Hz, 6H); LCMS:576.05 220 N-((1-cyanocyclopropyl)methyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-di Hydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-((1-cyanocyclopropyl)methyl)-2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.16 (t, J = 6.5 Hz, 1H), 8.67 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.73 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.44 (d, J = 6.6 Hz, 2H), 1.22-1.13 (m , 4H); LCMS:541.95 221 (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridin-6-yl)(2-fluoropyrrolidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(2-fluoropyrrolidin-1-yl)methanone) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.61 (s, 1H), 7.82-7.78 (m, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.60 (d, J = 1.7 Hz , 2H), 5.43-5.26 (m, 1H), 4.71 (d, J = 3.2 Hz, 4H), 4.11 (d, J = 16.9 Hz, 1H), 4.01-3.52 (m, 5H), 2.20-2.01 ( m, 2H); LCMS:517.0 222 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(Thietane-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thietan-3-yl)-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.55 (d, J = 7.9 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 5.13 (td, J = 17.1, 8.3 Hz, 1H ), 4.60 (s, 2H), 4.44 (s, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.52 (t, J = 9.2 Hz, 2H ), 3.22-3.18 (m, 2H), 2.29 (s, 3H); LCMS:554.35 223 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(3-Methylbut-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(3-methylbutan-2-yl)-5,6-dihydro-4H-thieno[2 ,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.76 (d, J = 6.1 Hz, 2H), 7.68 (d, J = 8.6 Hz, 1H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.08 (d, J = 17.1 Hz, 1H), 3.97 (d, J = 17.1 Hz, 1H), 3.74 (dd, J = 15.3, 7.0 Hz, 1H), 2.27 (s, 3H), 1.72 (td , J = 13.6, 6.8 Hz, 1H), 1.07 (d, J = 6.7 Hz, 3H), 0.87 (d, J = 6.7 Hz, 6H); LCMS:552.45 224 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran-2-yl)methyl)- 5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.88 (t, J = 5.8 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 16.8 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.85 (dd, J = 10.5, 2.3 Hz, 1H), 3.41-3.34 (m, 1H), 3.24 -3.16 (m, 2H), 2.28 (s, 3H), 1.76 (s, 1H), 1.57 (d, J = 12.8 Hz, 1H), 1.45-1.39 (m, 3H), 1.22-1.10 (m, 1H ); LCMS:580.5 225 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1 ,3,4-oxadiazol-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formamide (2-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.55 (t, J = 6.1 Hz, 1H), 8.77 (s, 1H), 8.18 (d, J = 10.8 Hz, 1H), 7.89-7.86 (m , 1H), 7.71 (d, J = 1.7 Hz, 2H), 4.94-4.76 (m, 6H), 4.16 (dd, J = 49.8, 17.0 Hz, 2H); LCMS:540.50 226 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethyl But-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.65 (d, J = 3.7 Hz, 1H), 8.19-8.05 (m, 2H), 7.78 (d, J = 4.4 Hz, 1H), 7.62 (d , J = 5.4 Hz, 2H), 4.75 (s, 4H), 4.15-3.91 (m, 3H), 1.12 (d, J = 6.8 Hz, 3H), 0.91 (s, 9H); LCMS:528.55 227 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(thiophen-2-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 9.37 (t, J = 6.2 Hz, 1H), 8.64 (s, 1H), 8.07 (s, 1H), 7.79-7.76 (m, 1H), 7.61 (d, J = 2.0 Hz, 2H), 7.36 (dd, J = 5.0, 1.3 Hz, 1H), 7.01-6.93 (m, 2H), 4.82-4.63 (m, 6H), 4.06 (dd, J = 49.6 , 17.1 Hz, 2H); LCMS:540.45 228 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2-(4-methylthiazol-5-yl)ethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(4-methylthiazol-5-yl)ethyl) -5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.80 (s, 1H), 8.04 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.59 (s, 2H ), 4.44 (s, 2H), 4.06 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.37 (dd, J = 12.6, 6.7 Hz, 2H), 2.30 (s , 3H), 2.25 (s, 3H); LCMS:607.0 229 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -((tetrahydrofuran-3-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran-3-yl)methyl)-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.05 (t, J = 5.9 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H ), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 16.9 Hz, 1H), 3.75-3.57 (m, 3H), 3.44 (dd, J = 8.4, 5.3 Hz, 1H), 3.18 (td, J = 13.1, 7.2 Hz, 2H), 2.46-2.41 (m, 1H), 2.28 (s, 3H), 1.95-1.87 (m, 1H), 1.57 (dt, J = 19.8, 6.2 Hz, 1H );LCMS:566.0 230 N-(2-cyclopentylethyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(2-cyclopentylethyl)-5-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 7.91 (t, J = 5.7 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.51 (d, J = 60.2 Hz, 3H), 4.01 (dd, J = 43.5, 17.1 Hz, 2H), 3.18 (dd, J = 14.2, 6.1 Hz, 2H), 2.28 (s, 3H), 1.77 (t, J = 6.4 Hz, 3H), 1.58-1.45 (m, 6H), 1.07 (d, J = 3.9 Hz, 2H); LCMS:578.8 231 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carboxamide) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.61 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.37 (dd, J = 5.1, 1.2 Hz, 1H ), 6.99-6.94 (m, 2H), 4.59-4.54 (m, 4H), 4.44 (s, 2H), 4.02 (dd, J = 43.4, 17.0 Hz, 2H), 2.31 (s, 3H); LCMS: 577.75 232 1-(2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro- 1H-pyrrolo[3,4-c]pyridine-6-carbonyl)piperidine-4-carbonitrile (1-(2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)piperidine-4-carbonitrile) ¹ H-NMR(400 MHz, DMSO- d ₆ ) δ 8.57 (s, 1H), 7.78-7.76 (m, 1H), 7.61-7.59 (m, 3H), 4.69 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.01-3.90 (m, 2H), 3.52-3.36 (m, 2H), 3.28-3.12 (m, 2H), 1.99-1.65 (m, 4H); LCMS: 539.75 233 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(1-methylpyrrolidin-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(1-methylpyrrolidin-3-yl)-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.01 (d, J = 7.1 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.58 (s, 2H), 4.43 (s, 2H ), 4.31-4.26 (m, 1H), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 2.68 (dd, J = 9.3, 7.3 Hz, 1H), 2.56 LCMS : 563.25 234 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thia Cyclobutan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thietan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide ) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 7.52-7.49 (m, 2H), 7.41 (t, J = 1.8 Hz, 1H), 6.11 (d, J = 8.1 Hz, 1H), 5.36 (td, J = 16.4, 8.2 Hz, 1H), 4.69-4.65 (m, 2H), 4.46 (t, J = 3.1 Hz, 2H), 3.86 (d, J = 16.1 Hz, 1H), 3.47-3.37 (m, 5H ), 2.43-2.39 (m, 3H); LCMS: 560.55 235 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiophene- 2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(thiophen-2-ylmethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 7.49 (d, J = 1.5 Hz, 2H), 7.41 (t, J = 1.8 Hz, 1H), 7.25 (d, J = 1.2 Hz, 0H), 7.04 (dd, J = 3.4, 1.2 Hz, 1H), 7.00-6.96 (m, 1H), 6.04 (t, J = 5.3 Hz, 1H), 4.77 (d, J = 5.1 Hz, 2H), 4.64 (d, J = 3.2 Hz, 2H), 4.46 (t, J = 2.9 Hz, 2H), 3.85 (d, J = 16.1 Hz, 1H), 3.45 (d, J = 16.1 Hz, 1H), 2.42 (d, J = 5.9 Hz, 3H); LCMS: 534 236 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(pentyl- 3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-3-methyl-N-(pentan-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 7.49 (d, J = 1.5 Hz, 2H), 7.41 (t, J = 1.8 Hz, 1H), 5.41 (d, J = 8.8 Hz, 1H), 4.64 (d, J = 3.2 Hz, 2H), 4.46 (t, J = 2.9 Hz, 2H), 3.97-3.91 (m, 1H), 3.86 (d, J = 16.1 Hz, 1H), 3.46 (d, J = 16.1 Hz, 1H), 2.40 (s, 3H), 1.69-1.61 (m, 2H), 1.53-1.42 (m, 2H), 0.96 (q, J = 7.5 Hz, 6H); LCMS: 535.85 237 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2- Methylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-methylbutyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.91 (t, J = 5.9 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 2.0 Hz, 2H), 4.51 (d, J = 58.9 Hz, 4H), 4.02 (dd, J = 49.9, 17.1 Hz, 2H), 3.21-2.97 (m, 2H), 2.32-2.28 (m, 3H), 1.59 (dd, J = 12.5, 6.8 Hz, 1H), 1.40-1.34 (m, 1H), 1.13-1.06 (m, 1H), 0.89-0.83 (m, 6H); LCMS: 549.9 238 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran -2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydrofuran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.93 (t, J = 5.7 Hz, 1H), 7.77 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.52 (d, J = 60.4 Hz, 4H), 4.10-3.96 (m, 2H), 3.94-3.91 (m, 1H), 3.78-3.73 (m, 1H), 3.61 (q, J = 7.3 Hz, 1H) , 3.26-3.21 (m, 2H), 2.32-2.29 (m, 3H), 1.90-1.76 (m, 3H), 1.60-1.53 (m, 1H); LCMS: 563.25 239 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrafluoromethyl) Hydrogen-2H-pyran-2-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran-2-yl)methyl)-5,6-dihydro-4H- thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.89 (t, J = 5.7 Hz, 1H), 7.78 (t, J = 2.0 Hz, 1H), 7.60 (d, J = 1.7 Hz, 2H), 4.53 (d, J = 60.6 Hz, 4H), 4.04 (dd, J = 50.0, 17.0 Hz, 2H), 3.89-3.86 (m, 1H), 3.43-3.36 (m, 1H), 3.27-3.18 (m, 2H), 2.32 (d, J = 11.2 Hz, 3H), 1.78 (s, 1H), 1.59 (d, J = 12.7 Hz, 1H), 1.45-1.34 (m, 3H), 1.23-1.11 (m, 1H ); LCMS: 517.95 240 N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-formamide (N-cyclobutyl-5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.14 (d, J = 7.6 Hz, 1H), 7.77 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.52 (d, J = 61.4 Hz, 4H), 4.32 (q, J = 8.2 Hz, 1H), 4.01 (dd, J = 50.1, 16.9 Hz, 2H), 2.27 (s, 3H), 2.20-2.13 (m , 2H), 2.06-2.01 (m, 2H), 1.67-1.60 (m, 2H), 1.15 (s, 1H); LCMS: 534 241 N-(1-cyanocyclohexyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclohexyl)-2-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.78 (s, 1H), 8.66 (s, 1H), 8.08 (s, 1H), 7.76 (d, J = 1.7 Hz, 1H), 7.60 (s , 2H), 4.74 (s, 4H), 4.12 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 2.35 (d, J = 12.7 Hz, 2H), 1.83 (t , J = 10.8 Hz, 2H), 1.72-1.68 (m, 2H), 1.62-1.50 (m, 2H), 1.34-1.22 (m, 2H); LCMS: 552.15 242 N-(1-cyclopropylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyclopropylethyl)-2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.59 (d, J = 8.8 Hz, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.05 (dd, J = 43.3, 16.9 Hz, 2H), 3.43-3.37 (m, 1H), 1.23 (d, J = 6.8 Hz, 3H), 1.11-1.05 (m, 1H), 0.47-0.41 (m, 1H), 0.38-0.32 (m, 1H), 0.27-0.18 (m, 2H); LCMS: 531 243 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( Methylthio)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylthio)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.89 (t, J = 6.1 Hz, 1H), 8.63 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.49 (dd, J = 13.7, 6.4 Hz, 2H), 2.67-2.64 (m, 2H), 2.10 (d, J = 18.3 Hz, 3H); LCMS: 536.95 244 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(3- Methylbut-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(3-methylbutan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.76 (t, J = 1.8 Hz, 1H), 7.67 (d, J = 8.6 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.59 (s, 2H), 4.44 (s, 2H), 4.02 (dd, J = 49.9, 17.1 Hz, 2H), 3.74 (d, J = 8.6 Hz, 1H), 2.27 (s, 3H), 1.71 (t , J = 6.7 Hz, 1H), 1.07 (d, J = 6.6 Hz, 3H), 0.87 (d, J = 6.8 Hz, 6H); LCMS: 548.2 245 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isoamyl- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isopentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.73 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.02 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.05 (dd, J = 42.7, 17.0 Hz, 2H), 3.33 (s, 1H), 3.28 (s, 1H), 1.62-1.52 (m, 1H), 1.42 (q, J = 7.1 Hz, 2H), 0.88 (d, J = 6.6 Hz, 6H); LCMS: 533 246 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoro Ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-fluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.92 (t, J = 6.0 Hz, 1H), 8.64 (d, J = 0.7 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.73 (s, 4H), 4.60 (t, J = 5.3 Hz, 1H), 4.49 (t, J = 5.1 Hz, 1H), 4.05 (dd, J = 43.0, 16.9 Hz, 2H ), 3.60 (dq, J = 25.6, 5.5 Hz, 2H); LCMS: 508.95 247 N-(1-cyano-1-cyclopropylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5- Dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyano-1-cyclopropylethyl)-2 -(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine -6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.79 (s, 1H), 8.67 (s, 1H), 8.09 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.74 (s , 4H), 4.11 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 1.70-1.61 (m, 4H), 0.67-0.62 (m, 3H), 0.55-0.49 ( m, 1H); LCMS: 556.15 248 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 ,1-trifluoro-3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.88 (d, J = 10.0 Hz, 1H), 8.69 (s, 1H), 8.09 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.74 (s, 4H), 4.55 (td, J = 17.2, 8.7 Hz, 1H), 4.11 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 2.33-2.28 (m, 1H), 0.99 (d, J = 6.6 Hz, 3H), 0.94 (d, J = 6.6 Hz, 3H); LCMS: 587 249 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -Difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.06 (t, J = 6.4 Hz, 1H), 8.66 (s, 1H), 8.07 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 6.29-5.98 (m, 1H), 4.73 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.70 (tdd, J = 15.3, 6.2, 4.2 Hz, 2H); LCMS: 527.05 250 N-cyclobutyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclobutyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.90 (d, J = 8.6 Hz, 1H), 8.63 (s, 1H), 8.01 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.71 (s, 4H), 4.44 (q, J = 8.4 Hz, 1H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 2.19-2.13 (m , 4H), 1.68-1.60 (m, 2H); LCMS: 517.05 251 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-isopropyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (s, 1H), 8.43 (d, J = 8.3 Hz, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.13-4.08 (m, 2H), 3.99 (d, J = 17.1 Hz, 1H), 1.18 (d, J = 6.4 Hz, 6H); LCMS: 505.1 252 N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.90 (t, J = 6.0 Hz, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 5.88 (dq, J = 22.4, 5.2 Hz, 1H), 5.14-5.04 (m, 2H), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.91 (t, J = 5.5 Hz, 2H); LCMS: 503.05 253 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(penta-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pentan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.29 (d, J = 9.2 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.8 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.77 (dd, J = 14.2, 5.0 Hz, 1H), 1.59-1.46 (m, 4H), 0.82 (t, J = 7.3 Hz, 6H); LCMS: 535.2 254 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-fluoropyrrolidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-fluoropyrrolidin-1-yl)methanone ) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.61 (s, 1H), 7.81 (d, J = 9.3 Hz, 1H), 7.77 (d, J = 6.4 Hz, 2H), 5.43-5.26 (m , 1H), 4.71 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.94-3.52 (m, 4H), 2.18-2.04 (m, 2H); LCMS: 535.05 255 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethyl But-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutan-2-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.76 (t, J = 1.8 Hz, 1H), 7.58-7.55 (m, 3H), 4.52 (d, J = 58.4 Hz, 4H), 4.09 (dd , J = 17.1, 2.0 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.91-3.85 (m, 1H), 2.30 (d, J = 15.6 Hz, 3H), 1.05 (d, J = 6.8 Hz, 3H), 0.88 (s, 9H); LCMS: 505.9 256 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isopropyl-3-methyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5- dihydroisoxazol-3-yl)-N-isopropyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.77-7.73 (m, 2H), 7.58 (d, J = 2.0 Hz, 2H), 4.51 (d, J = 60.4 Hz, 4H), 4.08 (d , J = 17.1 Hz, 1H), 4.02-3.93 (m, 2H), 2.27 (s, 3H), 1.13 (d, J = 6.6 Hz, 6H); LCMS: 563.5 257 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(5- Methylhex-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(5-methylhexan-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.76 (t, J = 1.8 Hz, 1H), 7.69 (d, J = 8.6 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.51 (d, J = 59.9 Hz, 4H), 4.08 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.87 (t, J = 6.5 Hz, 1H), 2.27 ( s, 3H), 1.53-1.40 (m, 3H), 1.17 (t, J = 7.5 Hz, 2H), 1.13-1.09 (m, 3H), 0.84 (d, J = 6.6 Hz, 6H); LCMS: 559.15 258 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-pentyl- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol -3-yl)-3-methyl-N-pentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.91 (t, J = 5.7 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.51 (d, J = 59.9 Hz, 4H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.9 Hz, 1H), 3.17 (q, J = 6.6 Hz, 2H), 2.28 ( s, 3H), 1.51-1.44 (m, 2H), 1.32-1.22 (m, 4H), 0.86 (t, J = 7.0 Hz, 3H); LCMS: 560.05 259 (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridin-6-yl)(4,4-difluoropiperidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(4,4-difluoropiperidin-1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.59 (s, 1H), 7.77 (s, 1H), 7.66 (s, 1H), 7.59 (s, 2H), 4.70 (s, 4H), 4.05 (dd, J = 49.0, 16.8 Hz, 2H), 3.74 (d, J = 5.1 Hz, 2H), 3.49 (s, 2H), 2.03 (d, J = 22.5 Hz, 4H); LCMS: 549.2 260 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((3,3-difluoro Cyclohexyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-N-((3,3-difluorocyclohexyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.91 (t, J = 6.4 Hz, 1H), 8.63 (s, 1H), 8.03 (s, 1H), 7.77 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.22 (td, J = 13.4, 6.6 Hz, 2H), 1.98 (s, 3H), 1.70 (dd, J = 35.6, 13.1 Hz, 3H), 1.53-1.34 (m, 2H), 1.02 (t, J = 11.5 Hz, 1H) ; LCMS: 577 261 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrafluoromethyl) Hydrogen-2H-pyran-4-yl)methyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5 -dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydro-4H- thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 7.49 (d, J = 1.5 Hz, 2H), 7.41 (t, J = 1.8 Hz, 1H), 5.82 (t, J = 6.0 Hz, 1H), 4.64 (d, J = 3.2 Hz, 2H), 4.47-4.44 (m, 2H), 3.99 (dd, J = 11.2, 3.4 Hz, 2H), 3.86 (d, J = 16.1 Hz, 1H), 3.48-3.35 ( m, 3H), 3.32 (t, J = 6.4 Hz, 2H), 2.40 (s, 3H), 1.89-1.84 (m, 1H), 1.67-1.64 (m, 2H), 1.37 (ddd, J = 25.2, 12.0, 4.4 Hz, 2H); LCMS: 535.15 262 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylamino) -2-oxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.88 (t, J = 5.9 Hz, 1H), 8.66 (s, 1H), 8.04 (s, 1H), 7.87 (d, J = 4.4 Hz, 1H ), 7.77 (t, J = 2.0 Hz, 1H), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.05 (dd, J = 49.6, 16.9 Hz, 2H), 3.88 (d , J = 5.9 Hz, 2H), 2.59 (d, J = 4.6 Hz, 3H); LCMS: 517.4 263 (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone((2-(5-(3,5-dichlorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone ) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.58 (s, 1H), 7.78-7.76 (m, 1H), 7.65-7.59 (m, 3H), 4.70 (s, 4H), 4.54-4.34 ( m, 1H), 4.11 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.76 (dd, J = 108.7, 13.1 Hz, 1H), 3.18-2.87 (m, 2H ), 2.66-2.60 (m, 1H), 1.96 (d, J = 13.7 Hz, 1H), 1.66-1.45 (m, 3H); LCMS: 580.7 264 N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-allyl-2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.57 (d, J = 10.5 Hz, 1H), 7.77 (dd, J = 6.1, 1.7 Hz, 2H), 7.60 (d, J = 8.1 Hz, 1H ), 5.88-5.74 (m, 1H), 5.27-5.08 (m, 2H), 4.69 (s, 4H), 4.12-3.85 (m, 4H), 2.90 (d, J = 29.8 Hz, 3H); LCMS: 516.65 265 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl Oxypropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxypropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (d, J = 0.7 Hz, 1H), 8.47 (d, J = 8.8 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.72 (s, 4H), 4.20 (dt, J = 14.8, 6.4 Hz, 1H), 4.12-3.97 (m, 2H), 3.43 (dd, J = 9.5, 6.4 Hz, 1H) , 3.35-3.33 (m, 1H), 3.25 (s, 3H), 1.16-1.14 (m, 3H); LCMS: 536.4 266 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(piperidin-1-yl)methanone ((2-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(piperidin-1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.56 (d, J = 1.0 Hz, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.56 (s, 1H), 4.68 (s, 4H ), 4.12-3.97 (m, 2H), 3.59 (t, J = 5.3 Hz, 2H), 3.27 (t, J = 5.4 Hz, 2H), 1.57 (dd, J = 21.6, 4.0 Hz, 4H), 1.44 (s, 2H); LCMS: 532.45 267 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-neopentyl- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-neopentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.64 (s, 1H), 8.57 (t, J = 6.7 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.16-3.14 (m, 2H), 0.88 (s, 9H); LCMS : 534.4 268 N-(2-cyanoethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanoethyl)-2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.59 (d, J = 1.7 Hz, 1H), 7.77 (d, J = 6.1 Hz, 2H), 7.63 (d, J = 22.0 Hz, 1H), 4.73 (d, J = 19.6 Hz, 4H), 4.05 (dd, J = 42.4, 17.0 Hz, 2H), 3.67 (dt, J = 37.4, 6.7 Hz, 2H), 3.01 (d, J = 15.2 Hz, 3H ), 2.91-2.84 (m, 2H); LCMS: 529.95 269 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl- N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.56 (d, J = 8.6 Hz, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.55 (d, J = 3.4 Hz, 1H), 4.68 (s, 4H), 4.10 (dd, J = 17.0, 3.1 Hz, 1H), 4.01-3.97 (m, 1H), 3.29 (d, J = 7.6 Hz, 1H), 3.15 (d, J = 7.6 Hz , 1H), 2.96 (s, 1H), 2.86 (s, 1H), 2.06-1.99 (m, 1H), 1.88-1.81 (m, 1H), 0.90 (d, J = 6.8 Hz, 3H), 0.67 ( d, J = 6.6 Hz, 3H); LCMS: 531 270 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(heptyl-2 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(heptan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (s, 1H), 8.41 (d, J = 8.8 Hz, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.03-3.96 (m, 2H), 1.58-1.43 (m, 2H), 1.23 (d, J = 5.1 Hz, 6H) , 1.14 (d, J = 6.6 Hz, 3H), 0.86-0.80 (m, 3H); LCMS: 562.6 271 N-(but-3-yn-2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(but-3-yn-2-yl)-2- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.96 (d, J = 8.6 Hz, 1H), 8.65 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.86-4.81 (m, 1H), 4.76 (d, J = 26.4 Hz, 4H), 4.05 (dd, J = 43.3, 16.9 Hz, 2H), 3.18-3.18 (m, 1H), 1.42 (d, J = 7.1 Hz, 3H); LCMS: 514.95 272 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro -2H-pyran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydro-2H-pyran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.57 (t, J = 6.0 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.05 (dd, J = 42.8, 16.9 Hz, 2H), 3.89-3.85 (m, 1H), 3.46-3.37 (m, 2H), 3.26 (dd, J = 13.2, 7.3 Hz, 2H), 1.74 (d, J = 2.7 Hz, 1H), 1.57 (d, J = 12.7 Hz, 1H), 1.44 (s, 3H), 1.22-1.14 (m, 1H); LCMS: 561.2 273 Azetidin-1-yl(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone (azetidin-1-yl(2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.52 (s, 1H), 8.06 (s, 1H), 7.57 (d, J = 6.1 Hz, 2H), 4.74-4.69 (m, 6H), 4.25 ( dd, J = 8.3, 7.3 Hz, 2H), 3.92-3.87 (m, 1H), 3.47 (d, J = 16.1 Hz, 1H), 2.40-2.32 (m, 2H); LCMS: 502.65 274 N-(cyclopentylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopentylmethyl)-2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.77 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H) , 4.72 (s, 4H), 4.05 (dd, J = 42.8, 16.9 Hz, 2H), 3.22 (t, J = 6.8 Hz, 2H), 2.16 (t, J = 7.3 Hz, 1H), 1.65-1.47 ( m, 6H), 1.27-1.21 (m, 2H); LCMS: 546.45 275 N-cyclohexyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclohexyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.48 (d, J = 0.7 Hz, 1H), 8.15 (s, 1H), 7.90 (d, J = 8.3 Hz, 1H), 7.57 (d, J = 5.9 Hz, 2H), 4.74 (d, J = 6.1 Hz, 4H), 3.98-3.87 (m, 2H), 3.47 (d, J = 16.1 Hz, 1H), 2.04-1.99 (m, 2H), 1.77 ( dt, J = 13.2, 3.9 Hz, 2H), 1.68-1.63 (m, 1H), 1.48-1.22 (m, 5H); LCMS: 544.7 276 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3 -Dimethylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3-dimethylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c ]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.16 (d, J = 10.0 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H), 3.93-3.85 (m, 1H), 1.14-1.09 (m, 3H) , 0.94-0.89 (m, 9H); LCMS: 546.85 277 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropiperidin-1-yl)methanone ((2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropiperidin- 1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.60 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.65 (d, J = 18.3 Hz, 1H), 4.70 (s, 4H ), 4.10 (d, J = 17.1 Hz, 1H), 4.02-3.94 (m, 2H), 3.87 (t, J = 11.6 Hz, 1H), 3.67 (t, J = 5.3 Hz, 1H), 3.41 (t , J = 5.0 Hz, 1H), 2.11-2.06 (m, 2H), 1.68 (dd, J = 15.5, 11.6 Hz, 2H); LCMS: 567 278 N-(2-cyclopentylethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyclopentylethyl)-2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.75 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.71 (s, 4H), 4.12-3.97 (m, 2H), 3.28 (d, J = 6.4 Hz, 2H), 1.79-1.73 (m, 3H), 1.59-1.41 (m, 6H), 1.18- 1.05 (m, 2H); LCMS: 558.7 279 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran- 2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.66-8.63 (m, 2H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.02-3.95 (m, 2H), 3.79-3.74 (m, 1H), 3.61 (dd, J = 14.4, 7.6 Hz, 1H), 3.41-3.34 (m, 2H ), 1.90-1.76 (m, 3H), 1.61-1.54 (m, 1H); LCMS: 546.95 280 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-propyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.77 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.29-3.22 (m, 2H), 1.53 (td, J = 14.6, 7.3 Hz, 2H), 0.85 (t, J = 7.3 Hz, 3H); LCMS: 504.95 281 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl Oxybut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxybutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.39 (d, J = 9.3 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.12-3.97 (m, 3H), 3.45 (dd, J = 9.8, 6.1 Hz, 1H), 3.37 (t, J = 4.8 Hz, 1H), 3.24 (s, 3H) , 1.63-1.47 (m, 2H), 0.85 (q, J = 7.6 Hz, 3H); LCMS: 549 282 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro- 2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.66 (d, J = 8.6 Hz, 1H), 8.63 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.85-3.80 (m, 1H), 2.73 (t, J = 11.7 Hz , 2H), 2.62 (d, J = 13.9 Hz, 2H), 2.03 (dd, J = 13.2, 3.2 Hz, 2H), 1.80-1.70 (m, 2H); LCMS: 563 283 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2- (Methylamino)-2-oxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5-(3,5- dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylamino)-2-oxoethyl)-5,6-dihydro-4H-thieno[2, 3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.99 (t, J = 5.7 Hz, 1H), 7.81 (t, J = 4.4 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.58 (d, J = 1.7 Hz, 2H), 4.61 (s, 2H), 4.45 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 17.1 Hz, 1H), 3.77 (d, J = 5.6 Hz, 2H), 2.59 (d, J = 4.4 Hz, 3H), 2.33 (s, 3H); LCMS: 589.15 284 N-(tert-butyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(tert-butyl)-2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.60 (s, 1H), 8.02 (s, 2H), 7.77 (d, J = 6.1 Hz, 2H), 4.71 (s, 4H), 4.05 (dd , J = 43.0, 17.1 Hz, 2H), 1.40 (s, 9H); LCMS: 519 285 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridine-3 -ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.45 (t, J = 6.4 Hz, 1H), 8.65 (s, 1H), 8.54 (d, J = 1.5 Hz, 1H), 8.43 (d, J = 3.4 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 7.71 (d, J = 7.8 Hz, 1H), 7.32 (dd, J = 7.7, 4.8 Hz, 1H ), 4.72 (s, 4H), 4.50 (d, J = 6.4 Hz, 2H), 4.10 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H); LCMS: 553.9 286 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl Base-2,5-dioxypyrrolidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl-2,5-dioxopyrrolidin-3-yl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.45 (d, J = 8.8 Hz, 1H), 8.66 (d, J = 0.7 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.91-4.86 (m, 1H), 4.76 (d, J = 21.0 Hz, 4H), 4.12-3.97 (m, 2H), 3.00 (dd, J = 17.4, 9.3 Hz, 1H) , 2.86 (s, 3H), 2.62 (dd, J = 17.5, 5.3 Hz, 1H); LCMS: 573.9 287 N-(1-cyanocyclohexyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (N-(1-cyanocyclohexyl)-5-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole- 2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.30 (s, 1H), 7.76 (d, J = 6.1 Hz, 2H), 5.74 (s, 0H), 4.53 (d, J = 61.4 Hz, 4H ), 4.08 (d, J = 16.9 Hz, 1H), 3.97 (d, J = 16.9 Hz, 1H), 2.31 (d, J = 6.6 Hz, 3H), 2.23 (d, J = 13.7 Hz, 2H), 1.81 (t, J = 10.0 Hz, 2H), 1.67-1.63 (m, 2H), 1.53-1.45 (m, 3H), 1.32 (dd, J = 11.9, 9.7 Hz, 1H); LCMS: 553 288 N-cyclopentyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-cyclopentyl-2-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.61 (s, 1H), 8.51 (d, J = 8.1 Hz, 1H), 8.02 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.75 (d, J = 28.1 Hz, 4H), 4.23 (td, J = 14.5, 7.3 Hz, 1H), 4.12-4.06 (m, 1H), 3.99 (d, J = 16.9 Hz, 1H), 1.91 -1.83 (m, 2H), 1.72-1.52 (m, 6H); LCMS: 530.7 289 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-pentyl-2 ,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazol-3-yl)-N-pentyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.49 (s, 1H), 8.15 (s, 1H), 8.00 (t, J = 5.9 Hz, 1H), 7.57 (d, J = 5.9 Hz, 2H) , 4.75 (d, J = 5.6 Hz, 4H), 3.92-3.87 (m, 1H), 3.49-3.44 (m, 3H), 1.65 (q, J = 7.2 Hz, 2H), 1.39-1.34 (m, 4H ), 0.93-0.89 (m, 3H); LCMS: 534.45 290 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro- 2H-pyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (t, J = 4.2 Hz, 2H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.72 (s, 4H ), 4.12-3.97 (m, 3H), 3.85 (dd, J = 8.2, 3.1 Hz, 2H), 3.41-3.34 (m, 2H), 1.71-1.62 (m, 4H); LCMS: 546.95 291 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoroazetidin-1-yl)methanone ((2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3 -difluoroazetidin-1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.04 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 4.98 (t, J = 12.5 Hz, 2H ), 4.72 (s, 4H), 4.50 (t, J = 12.6 Hz, 2H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H); LCMS: 538.95 292 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -(2-(methylamino)-2-oxyethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide (5-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-(2-(methylamino)-2-oxoethyl)-5, 6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 7.99 (t, J = 5.9 Hz, 1H), 7.81 (d, J = 4.4 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.60 (s, 2H), 4.45 (s, 2H), 4.07 (d, J = 16.9 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.77 (d, J = 5.6 Hz, 2H), 2.59 (d, J = 4.6 Hz, 3H), 2.33 (s, 3H); LCMS: 555.7 293 (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H- Pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropiperidin-1-yl)methanone ((2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl )-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropiperidin-1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.59 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.64 (d, J = 17.9 Hz, 1H), 7.60 (d, J = 1.7 Hz, 2H), 4.70 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.01-3.94 (m, 2H), 3.87 (t, J = 12.0 Hz, 1H), 3.67 (t , J = 5.3 Hz, 1H), 3.41 (s, 1H), 2.14-2.04 (m, 2H), 1.69 (t, J = 7.7 Hz, 2H); LCMS: 548.95 294 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methyl ylbut-3-yn-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbut-3-yn-2-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (d, J = 0.7 Hz, 1H), 8.33 (s, 1H), 8.04 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H ), 4.76 (d, J = 25.9 Hz, 4H), 4.12-4.06 (m, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.20 (s, 1H), 1.64 (s, 6H); LCMS : 529.1 295 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4 -Difluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4-difluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.31 (t, J = 6.2 Hz, 1H), 8.65 (d, J = 0.5 Hz, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 7.37 (td, J = 8.7, 6.8 Hz, 1H), 7.22-7.17 (m, 1H), 7.02 (tt, J = 8.6, 1.3 Hz, 1H), 4.72 (s, 4H) , 4.50 (d, J = 6.1 Hz, 2H), 4.10 (d, J = 16.9 Hz, 1H), 4.02-3.97 (m, 1H); LCMS: 588.95 296 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-( Trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.49 (t, J = 6.4 Hz, 1H), 8.66 (s, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 7.67 (d, J = 8.1 Hz, 2H), 7.51 (d, J = 8.1 Hz, 2H), 4.73 (s, 4H), 4.57 (d, J = 6.4 Hz, 2H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H); LCMS: 621.2 297 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro -2-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-2-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.43 (t, J = 6.2 Hz, 1H), 8.68 (s, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 7.67-7.60 (m, 1H), 7.51-7.46 (m, 2H), 4.78 (d, J = 34.7 Hz, 4H), 4.65 (d, J = 5.9 Hz, 2H), 4.13-4.07 (m, 1H), 4.00 (d, J = 17.1 Hz, 1H); LCMS: 639.2 298 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( Methylamino)-2-oxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(methylamino)-2-oxoethyl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.87 (t, J = 5.9 Hz, 1H), 8.66 (s, 1H), 8.05 (s, 1H), 7.86 (d, J = 4.6 Hz, 1H ), 7.78 (d, J = 6.4 Hz, 2H), 4.76 (d, J = 25.9 Hz, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.89-3.85 (m, 2H), 2.59 (d, J = 4.6 Hz, 3H); LCMS: 535.8 299 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( 3,5-Dimethylisoxazol-4-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-2, 3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.87 (t, J = 6.2 Hz, 1H), 8.62 (s, 1H), 8.02 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.03-3.97 (m, 1H), 3.40-3.35 (m, 2H), 2.56 (t, J = 6.8 Hz, 2H) , 2.21 (s, 3H), 2.13 (s, 3H); LCMS: 587.85 300 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(2-oxyl-7-azaspiro[3.5]non-7-yl)methanone ((2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl) (2-oxa-7-azaspiro[3.5]nonan-7-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.56 (d, J = 0.7 Hz, 1H), 7.77 (d, J = 6.1 Hz, 2H), 7.56 (s, 1H), 4.69 (s, 4H ), 4.32 (dd, J = 17.9, 5.9 Hz, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.02-3.98 (m, 1H), 3.55 (t, J = 5.6 Hz, 2H), 3.24 (t, J = 5.4 Hz, 2H), 1.82 (t, J = 5.5 Hz, 2H), 1.74 (t, J = 5.5 Hz, 2H); LCMS: 573 301 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl)piperidin-1-yl)methanone ((2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl )piperidin-1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.58 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.62 (d, J = 22.3 Hz, 1H), 4.69 (s, 4H ), 4.54-4.34 (m, 1H), 4.10 (d, J = 17.0 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.62 (d, J = 13.7 Hz, 1H), 3.18-2.87 (m, 2H), 2.61 (d, J = 11.0 Hz, 1H), 1.96 (d, J = 12.7 Hz, 1H), 1.66-1.46 (m, 3H); LCMS: 599.05 302 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methyl ylallyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylallyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.89 (t, J = 6.4 Hz, 1H), 8.64 (d, J = 0.7 Hz, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.76-4.72 (m, 6H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H), 3.84 (d, J = 6.1 Hz, 2H ), 1.69 (s, 3H); LCMS: 517 303 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 -Tetrahydrodioxide-2H-thiopyran-4-yl))-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2,3-dihydro -1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.88 (d, J = 8.6 Hz, 1H), 8.64 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.24-4.15 (m, 1H), 4.10 (d, J = 16.9 Hz, 1H), 4.03-3.97 (m, 1H), 3.36 (d, J = 3.7 Hz, 2H) , 3.07 (d, J = 12.2 Hz, 2H), 2.19 (q, J = 11.9 Hz, 2H), 2.07-1.98 (m, 2H); LCMS: 595.05 304 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro -3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.51 (t, J = 6.5 Hz, 1H), 8.65 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.2 Hz, 2H ), 7.73-7.67 (m, 2H), 7.47-7.42 (m, 1H), 4.72 (s, 4H), 4.52 (d, J = 6.4 Hz, 2H), 4.10 (d, J = 17.1 Hz, 1H) , 3.99 (d, J = 16.9 Hz, 1H); LCMS: 638.9 305 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro -3-(trifluoromethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-fluoro-3-(trifluoromethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.48 (t, J = 6.4 Hz, 1H), 8.65 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.2 Hz, 2H ), 7.50-7.37 (m, 3H), 4.72 (s, 4H), 4.49 (d, J = 6.4 Hz, 2H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz , 1H); LCMS: 654.9 306 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2- Oxypiperidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxopiperidin-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.84 (d, J = 7.6 Hz, 1H), 8.64 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 7.68 (s, 1H), 4.73 (s, 4H), 4.34-4.28 (m, 1H), 4.12-3.97 (m, 2H), 3.16 (d, J = 5.4 Hz, 2H), 2.19-2.14 ( m, 1H), 1.82-1.74 (m, 3H); LCMS: 559.5 307 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((3- Ethyloxetan-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((3-ethyloxetan-3-yl)methyl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.99 (t, J = 6.5 Hz, 1H), 8.65 (s, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.0 Hz, 2H ), 4.73 (s, 4H), 4.44 (d, J = 5.9 Hz, 2H), 4.21 (d, J = 5.9 Hz, 2H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.51 (d, J = 6.6 Hz, 2H), 1.61 (q, J = 7.3 Hz, 2H), 0.90 (t, J = 7.3 Hz, 3H); LCMS: 561.1 308 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( 3,5-Dimethyl-1H-pyrazol-1-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(3,5-dimethyl-1H-pyrazol-1-yl )ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (s, 1H), 8.42 (t, J = 6.0 Hz, 1H), 8.13 (s, 1H), 7.57 (d, J = 6.1 Hz, 2H) , 5.79 (s, 1H), 4.74 (d, J = 4.2 Hz, 4H), 4.20 (t, J = 5.9 Hz, 2H), 3.91-3.83 (m, 3H), 3.46 (d, J = 16.1 Hz, 1H), 2.23 (s, 3H), 2.18 (s, 3H); LCMS: 585 309 N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-N-propyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(cyclopropylmethyl)-2-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-propyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide ) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.55 (d, J = 4.6 Hz, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.55 (s, 1H), 4.69 (s, 4H ), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.46 (t, J = 7.5 Hz, 1H), 3.33 (s, 1H), 3.25 (t, J = 7.6 Hz, 1H), 3.11 (d, J = 6.8 Hz, 1H), 1.67-1.47 (m, 2H), 1.22-0.94 (m, 1H), 0.92-0.82 (m, 2H), 0.64 (t, J = 7.3 Hz, 1H), 0.50-0.46 (m, 1H), 0.40-0.35 (m, 1H), 0.31-0.27 (m, 1H), 0.02 (q, J = 5.0 Hz, 1H); LCMS: 558.55 310 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4 ,6-trifluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4,6-trifluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.09 (t, J = 5.7 Hz, 1H), 8.61 (s, 1H), 8.02 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H ), 7.14 (t, J = 8.7 Hz, 2H), 4.71 (s, 4H), 4.51 (d, J = 5.6 Hz, 2H), 4.12-3.97 (m, 2H); LCMS: 607.05 311 N-(2-(cyclopropylamino)-2-oxyethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-Dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-(cyclopropylamino)-2 -oxoethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.79 (t, J = 5.7 Hz, 1H), 8.66 (s, 1H), 8.05 (d, J = 5.8 Hz, 2H), 7.78 (d, J = 6.4 Hz, 2H), 4.73 (s, 4H), 4.05 (dd, J = 42.8, 17.1 Hz, 2H), 3.86 (d, J = 5.8 Hz, 2H), 2.63-2.60 (m, 1H), 0.60 (td, J = 7.0, 4.8 Hz, 2H), 0.42-0.38 (m, 2H); LCMS: 559.45 312 (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-di Hydrogen-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropyrrolidin-1-yl)methanone ((2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)(3,3-difluoropyrrolidin- 1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (s, 1H), 7.85 (d, J = 21.3 Hz, 1H), 7.77 (d, J = 6.4 Hz, 2H), 4.75-4.70 (m , 4H), 4.19 (t, J = 13.0 Hz, 1H), 4.12-4.06 (m, 1H), 4.02-3.89 (m, 3H), 3.75 (t, J = 7.5 Hz, 1H), 2.46-2.39 ( m, 2H); LCMS: 553.15 313 N-(1-cyanocyclopropyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyanocyclopropyl)-2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.71 (s, 1H), 8.64 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.73 (s , 4H), 4.12-3.97 (m, 2H), 1.54 (dd, J = 8.3, 5.5 Hz, 2H), 1.32 (dd, J = 8.4, 5.7 Hz, 2H); LCMS: 528.1 314 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbutan-3 -Alkyn-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylbut-3-yn-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (d, J = 1.0 Hz, 1H), 8.33 (s, 1H), 8.04 (d, J = 0.7 Hz, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d, J = 1.7 Hz, 2H) , 4.73 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.20 (s, 1H), 1.64 (s, 6H), ; LCMS: 511 315 N-(but-3-yn-2-yl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(but-3-yn-2-yl)-2-(5-( 3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.95 (d, J = 8.6 Hz, 1H), 8.64 (s, 1H), 8.04 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.87-4.81 (m, 1H), 4.76 (d, J = 24.9 Hz, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.98 (d , J = 17.1 Hz, 1H), 3.17 (d, J = 2.7 Hz, 1H), 1.42 (d, J = 6.8 Hz, 3H), ; LCMS: 497.2 316 N-(2-nitrile ethyl)-2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanoethyl)-2-(5-(3,5-dichlorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.59 (d, J = 1.7 Hz, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.63 (d, J = 22.5 Hz, 3H) , 4.70 (s, 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.67 (dt, J = 37.3, 6.8 Hz, 2H), 3.01 (d, J = 15.2 Hz, 3H), 2.91-2.84 (m, 2H), ; LCMS: 512 317 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.63 (s, 1H), 8.37 (d, J = 9.5 Hz, 1H), 8.03 (s, 1H), 7.77 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.5 Hz, 2H), 4.72 (s, 4H), 4.05 (dd, J = 49.2, 17.1 Hz, 2H), 3.86-3.77 (m, 1H), 1.79 (td, J = 13.6, 6.7 Hz, 1H), 1.13-1.08 (m, 3H), 0.92-0.84 (m, 6H); LCMS: 515.1 318 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,5-difluorobenzene Methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-(3,5-difluorobenzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.49 (t, J = 6.1 Hz, 1H), 8.66 (s, 1H), 8.05 (s, 1H), 7.77 (s, 1H), 7.60 (s , 2H), 7.08 (t, J = 9.3 Hz, 1H), 7.00 (d, J = 6.4 Hz, 2H), 4.73 (s, 4H), 4.49 (d, J = 6.1 Hz, 2H), 4.05 (dd , J = 49.4, 17.0 Hz, 2H); LCMS: 571.2 319 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -Difluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.97 (t, J = 6.7 Hz, 1H), 8.66 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.73 (s, 4H), 4.13-3.98 (m, 2H), 3.75 (td, J = 13.9, 6.7 Hz, 2H), 1.60 (t, J = 19.1 Hz, 3H); LCMS: 540.84 320 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 ,1-trifluoro-2-methylprop-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.64 (s, 1H), 8.33 (s, 1H), 8.06 (s, 1H), 7.77 (d, J = 6.1 Hz, 2H), 4.73 (s , 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 1.65 (s, 6H); LCMS: 573.15 321 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-( Trifluoromethyl)oxetan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3, 5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-(trifluoromethyl)oxetan-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.95 (s, 1H), 8.71 (d, J = 0.7 Hz, 1H), 8.07 (s, 1H), 7.80 (d, J = 6.1 Hz, 2H ), 4.94 (d, J = 7.8 Hz, 2H), 4.74 (d, J = 8.3 Hz, 6H), 4.13 (d, J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H); LCMS: 587.05 322 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-( Trifluoromethyl)pent-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-(trifluoromethyl)pentan-3-yl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.65 (s, 1H), 8.17 (s, 1H), 8.07 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 4.73 (s , 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 2.23 (td, J = 14.5, 7.0 Hz, 2H), 2.02 (td, J = 14.4, 7.0 Hz, 2H), 0.91 (t, J = 7.2 Hz, 6H); LCMS: 600.85 323 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( Trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.45 (s, 1H), 8.64 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.72 (s , 4H), 4.05 (dd, J = 43.7, 16.8 Hz, 2H), 1.32-1.28 (m, 2H), 1.18 (s, 2H); LCMS: 570.8 324 (3-amino-3-(trifluoromethyl)azetidin-1-yl)(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro Methyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone ((3-amino -3-(trifluoromethyl)azetidin-1-yl)(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.55-8.73 (1H), 7.95-8.09 (1H), 7.68-7.88 (2H), 4.61-4.83 (5H), 4.36-4.51 (1H), 4.05 -4.25 (2H), 3.87-4.04 (2H), 2.74-2.85 (2H); LCMS: 586.15 325 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 , 1-trifluoro-2-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-formamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-2-methylbutan-2-yl)-2,3 -dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, MeOD) δ 8.59 (d, J = 1.0 Hz, 1H), 8.08 (d, J = 0.7 Hz, 1H), 7.72 (d, J = 6.1 Hz, 2H), 4.78 (s , 4H), 4.11 (d, J = 16.9 Hz, 1H), 3.85 (d, J = 16.9 Hz, 1H), 2.46 (d, J = 6.8 Hz, 1H), 1.85 (s, 1H), 1.65 (s , 3H), 0.99 (t, J = 7.5 Hz, 3H); LCMS: 586.8 326 tert-butyl-2-(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)-1-methylhydrazine-1-carboxylate (tert-butyl 2-(2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl) -1-methylhydrazine-1-carboxylate) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.49 (s, 1H), 8.63 (s, 1H), 8.04 (s, 1H), 7.74 (d, J = 6.1 Hz, 2H), 4.74 (s , 4H), 4.09-3.88 (m, 2H), 1.51-1.25 (m, 9H); LCMS: 589.95 327 N-(3-cyanopent-3-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(3-cyanopentan-3-yl)-2-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (s, 1H), 8.09 (s, 1H), 8.03 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 4.72 (s , 4H), 4.05 (dd, J = 42.2, 16.8 Hz, 2H), 2.15 (q, J = 7.0 Hz, 2H), 1.85 (dd, J = 13.4, 7.3 Hz, 2H), 0.92 (t, J = 7.3 Hz, 6H); LCMS: 556.6 328 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(tert-amyl )-2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-(tert-pentyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.60 (d, J = 0.7 Hz, 1H), 8.02 (s, 1H), 7.92 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H ), 4.71 (s, 4H), 4.05 (dd, J = 42.3, 16.9 Hz, 2H), 1.78 (q, J = 7.5 Hz, 2H), 1.34 (s, 6H), 0.80 (t, J = 7.5 Hz , 3H); LCMS: 533.2 329 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyl Tetrahydrofuran-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyltetrahydrofuran-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.62 (d, J = 0.7 Hz, 1H), 8.50 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.12-3.97 (m, 3H), 3.81-3.77 (m, 2H), 3.62 (d, J = 8.8 Hz, 1H), 2.44 (dd, J = 12.8, 7.0 Hz, 1H), 1.98-1.91 (m, 1H), 1.47 (s, 3H); LCMS: 547.05 330 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methyl Oxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-methoxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrrolo[ 3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.60 (d, J = 0.6 Hz, 1H), 8.13 (s, 1H), 8.02 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 17.1 Hz, 1H), 3.44 (s, 2H), 3.31 (s, 3H), 1.37 (s , 6H); LCMS: 549.1 331 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4 ,4-trimethylpent-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,4,4-trimethylpentan-2-yl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.59 (s, 1H), 8.04 (d, J = 9.2 Hz, 2H), 7.77 (d, J = 6.1 Hz, 2H), 4.71 (s, 4H ), 4.10 (d, J = 17.1 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 1.81 (s, 2H), 1.45 (s, 6H), 0.93 (d, J = 14.4 Hz, 9H ); LCMS: 576.45 332 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3,3-tri Fluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N-(3,3,3-trifluoropropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.99 (t, J = 6.1 Hz, 1H), 8.64 (s, 1H), 8.05 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.11 (d, J = 17.1 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 3.54 (q, J = 6.7 Hz, 2H), 2.63-2.53 (m, 2H); LCMS: 540.75 333 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-tri Fluoro-3-methylbut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3 ,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.88 (d, J = 10.0 Hz, 1H), 8.69 (s, 1H), 8.09 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.74 (s, 4H), 4.55 (q, J = 8.6 Hz, 1H), 4.06 (dd, J = 49.3, 17.0 Hz, 2H), 2.30 (q , J = 6.8 Hz, 1H), 0.99 (d, J = 6.6 Hz, 3H), 0.94 (d, J = 6.6 Hz, 3H); LCMS: 568.5 334 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1-dioxide tetra Hydrogen-2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-pyrrolo[3,4- c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.88 (d, J = 8.3 Hz, 1H), 8.63 (s, 1H), 8.03 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.72 (s, 4H), 4.22-4.18 (m, 1H), 4.11 (d, J = 16.9 Hz, 1H), 3.98 (d, J = 16.9 Hz , 1H), 3.07 (d, J = 12.5 Hz, 2H), 2.23-2.14 (m, 2H), 2.06 (d, J = 12.0 Hz, 2H), 1.25-1.21 (m, 1H); LCMS: 576.95 335 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylallyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(2-methylallyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.90 (t, J = 6.5 Hz, 1H), 8.64 (s, 1H), 8.04 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H ), 7.60 (d, J = 1.6 Hz, 2H), 4.76-4.73 (m, 6H), 4.05 (dd, J = 49.0, 17.0 Hz, 2H), 3.84 (d, J = 6.4 Hz, 2H), 1.69 (s, 3H); LCMS: 498.45 336 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-methylcyclopropyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5 -dihydroisoxazol-3-yl)-N-(2-methylcyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.68 (d, J = 4.9 Hz, 1H), 8.60 (d, J = 10.3 Hz, 1H), 8.01 (s, 1H), 7.76 (t, J = 1.8 Hz, 1H), 7.60 (d, J = 1.5 Hz, 2H), 4.71 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H), 2.59 (dd, J = 7.8, 4.4 Hz, 1H), 1.05-0.94 (m, 4H), 0.85-0.80 (m, 1H), 0.49-0.45 (m, 1H); LCMS: 498.5 337 2-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-(trifluoromethyl base)cyclopropyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-(trifluoromethyl)cyclopropyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.87 (t, J = 6.5 Hz, 1H), 8.65 (s, 1H), 8.05 (s, 1H), 7.77 (t, J = 1.8 Hz, 1H ), 7.60 (d, J = 1.7 Hz, 2H), 4.73 (s, 4H), 4.05 (dd, J = 49.2, 17.1 Hz, 2H), 3.61 (d, J = 6.6 Hz, 2H), 0.96-0.88 (m, 4H); LCMS: 566.65 338 N-(1-cyclopropyl-2,2,2-trifluoroethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(1-cyclopropyl-2, 2,2-trifluoroethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo [3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.28 (d, J = 9.5 Hz, 1H), 8.69 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.74 (s, 4H), 4.13-3.98 (m, 3H), 1.43 (tt, J = 13.0, 4.9 Hz, 1H), 0.71-0.65 (m, 1H), 0.59 (td, J = 9.8, 5.0 Hz, 1H), 0.53-0.46 (m, 1H), 0.22 (td, J = 9.9, 4.6 Hz, 1H); LCMS: 584.8 339 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 ,1-trifluorobut-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,1-trifluorobutan-2-yl)-2,3-dihydro-1H-pyrrolo[3, 4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.07 (d, J = 9.5 Hz, 1H), 8.68 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.74-4.59 (m, 5H), 4.06 (dd, J = 43.3, 17.0 Hz, 2H), 1.94-1.75 (m, 2H), 0.88 (t, J = 7.3 Hz, 3H); LCMS: 572.4 340 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1- (Hydroxymethyl)cyclobutyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-(hydroxymethyl)cyclobutyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4 -c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.80 (t, J = 6.3 Hz, 1H), 8.63 (s, 1H), 8.06 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.80 (t, J = 5.7 Hz, 1H), 4.72 (s, 4H), 4.10 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.8 Hz, 1H), 3.41 (dd, J = 13.0, 6.0 Hz, 4H), 1.83-1.66 (m, 6H); LCMS: 560.65 341 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((4, 4-difluorocyclohexyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((4,4-difluorocyclohexyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c] pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.85 (t, J = 6.2 Hz, 1H), 8.63 (s, 1H), 8.03 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.72 (s, 4H), 4.10 (d, J = 16.9 Hz, 1H), 3.99 (d, J = 17.1 Hz, 1H), 3.21 (t, J = 6.5 Hz, 2H), 1.97 (t, J = 9.9 Hz, 2H), 1.81-1.67 (m, 5H), 1.24-1.18 (m, 2H); LCMS: 594.5 342 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( 1-Methyl-1H-pyrazol-4-)yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(1-methyl-1H-pyrazol-4-yl)ethyl)- 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.68 (d, J = 8.6 Hz, 1H), 8.61 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 7.61 (s, 1H), 7.37 (s, 1H), 5.14-5.10 (m, 1H), 4.72 (s, 4H), 4.12-3.97 (m, 2H), 3.76 (s, 3H), 1.47 ( d, J = 6.7 Hz, 3H); LCMS: 570.5 343 Methyl-2-cyclopropyl-2-(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamido)propionate (methyl 2-cyclopropyl-2-(2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamido )propanoate) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.65 (s, 1H), 8.54 (s, 1H), 8.01 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.73 (d , J = 5.1 Hz, 4H), 4.10 (d, J = 16.9 Hz, 1H), 4.00 (d, J = 16.9 Hz, 1H), 3.59 (s, 3H), 1.49-1.42 (m, 1H), 1.36 (s, 3H), 0.51-0.38 (m, 4H); LCMS: 588.8 344 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( Hydroxymethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-(hydroxymethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.71 (s, 1H), 8.60 (s, 1H), 8.02 (s, 1H), 7.77 (d, J = 6.1 Hz, 2H), 4.71 (t , J = 5.7 Hz, 5H), 4.12-4.06 (m, 1H), 3.99 (d, J = 16.9 Hz, 1H), 3.50 (d, J = 5.6 Hz, 2H), 0.77 (s, 4H); LCMS : 532.5 345 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 , 2-trifluoro-1-(pyridin-2-yl)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5- (3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoro-1-(pyridin-2-yl)ethyl )-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.49 (dd, J = 9.2, 1.8 Hz, 1H), 8.74-8.71 (m, 2H), 8.16 (s, 1H), 7.94 (td, J = 7.7, 1.7 Hz, 1H), 7.82 (d, J = 7.6 Hz, 1H), 7.78 (d, J = 6.1 Hz, 2H), 7.51 (ddd, J = 7.6, 4.8, 1.0 Hz, 1H), 6.21 ( q, J = 8.0 Hz, 1H), 4.75 (d, J = 8.9 Hz, 4H), 4.11 (dd, J = 17.1, 1.2 Hz, 1H), 4.00 (dd, J = 17.1, 2.1 Hz, 1H); LCMS: 621.65 346 N-(2-cyanopropan-2-yl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (N-(2-cyanopropan-2-yl)-2-(5 -(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6- carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.90 (s, 1H), 8.66 (s, 1H), 8.08 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.74 (s , 4H), 4.11 (d, J = 17.1 Hz, 1H), 4.00 (d, J = 16.8 Hz, 1H), 1.70 (d, J = 14.4 Hz, 6H); LCMS: 529.65 347 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1- Isopropyl-1H-pyrazol-4-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3 ,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-isopropyl-1H-pyrazol-4-yl)methyl)-2,3- dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.02 (t, J = 6.1 Hz, 1H), 8.62 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 7.64 (s, 1H), 7.35 (s, 1H), 4.72 (s, 4H), 4.45-4.38 (m, 1H), 4.31 (d, J = 6.1 Hz, 2H), 4.05 (dd, J = 42.9, 17.0 Hz, 2H), 1.35 (d, J = 6.4 Hz, 6H); LCMS: 584.45 348 2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-methylcyclopropane Base) methyl) -2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl) -4,5-dihydroisoxazol-3-yl)-N-((1-methylcyclopropyl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.68-8.64 (m, 2H), 8.04 (s, 1H), 7.76 (t, J = 2.0 Hz, 1H), 7.60 (d, J = 1.7 Hz , 2H), 4.73 (s, 4H), 4.13-3.97 (m, 2H), 3.21 (d, J = 6.4 Hz, 2H), 1.02 (s, 3H), 0.49 (dd, J = 5.5, 4.0 Hz, 2H), 0.23 (dd, J = 5.7, 4.0 Hz, 2H); LCMS: 512.6 349 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N -Neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N-neopentyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.76 (t, J = 6.0 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.51 (d, J = 55.3 Hz, 4H), 4.10-3.93 (m, 2H), 3.65-3.57 (m, 2H), 2.26 (t, J = 14.8 Hz, 3H), 1.00-0.93 (m, 9H); LCMS: 525.35 350 N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (N-cyclopropyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.95 (d, J = 5.2 Hz, 1H), 7.75 (d, J = 6.1 Hz, 2H), 7.52 (s, 1H), 4.51 (d, J = 49.2 Hz, 4H), 4.01 (dd, J = 48.0, 17.1 Hz, 2H), 3.36-3.32 (m, 1H), 0.86-0.74 (m, 4H); LCMS: 547.85 351 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl- 3-Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-isobutyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.85 (t, J = 5.4 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.57 (s, 2H), 4.43 (s, 2H ), 4.07 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 17.1 Hz, 1H), 3.48 (dd, J = 6.8, 5.6 Hz, 2H), 2.23 (t, J = 23.2 Hz, 3H ), 2.13-2.03 (m, 1H), 0.91 (dd, J = 15.9, 6.8 Hz, 6H); LCMS: 568 352 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -Difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2-difluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide ) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.38 (t, J = 5.5 Hz, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.63 (s, 1H), 6.27 (tt, J = 55.8, 4.1 Hz, 1H), 4.53 (d, J = 46.5 Hz, 4H), 4.18-4.05 (m, 3H), 3.95 (d, J = 17.1 Hz, 1H); LCMS: 565.9 353 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(ethoxy Methyl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(ethoxymethyl)-N-(prop-2-yn-1-yl)-2, 3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.59 (s, 1H), 7.74 (d, J = 6.4 Hz, 2H), 7.66 (s, 1H), 4.94 (s, 2H), 4.72 (d , J = 5.5 Hz, 4H), 4.31 (d, J = 2.4 Hz, 2H), 4.07 (d, J = 16.8 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 1.03 (s, 3H ) 3.37 (d, J = 16.5 Hz, 2H), 3.05 (s, 1H), ; LCMS: 558.6 354 Ethyl(2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3 -Dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)(prop-2-yn-1-yl)carbamate (ethyl (2-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbonyl)(prop-2 -yn-1-yl)carbamate) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.57 (s, 1H), 7.80-7.77 (m, 3H), 4.72 (s, 4H), 4.50 (d, J = 2.4 Hz, 2H), 4.13 -3.91 (m, 4H), 3.25 (t, J = 2.3 Hz, 1H), 0.82 (t, J = 7.2 Hz, 3H); LCMS: 572.4 355 N-(cyclopropylmethyl)-2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thiocarbamide (N-(cyclopropylmethyl)-2-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.86 (t, J = 5.8 Hz, 1H), 8.61 (s, 1H), 8.47 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.73 (s, 4H), 4.05 (dd, J = 44.9, 17.1 Hz, 2H), 3.62 (t, J = 6.4 Hz, 2H), 1.31-1.22 (m, 1H), 0.48-0.44 (m, 2H), 0.35-0.31 (m, 2H); LCMS: 533.05 356 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methyl Butyl-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thioamide (2-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3-methylbutan-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.48 (d, J = 8.9 Hz, 1H), 8.60 (s, 1H), 8.43 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.73 (s, 4H), 4.51-4.46 (m, 1H), 4.05 (dd, J = 44.3, 17.1 Hz, 2H), 2.08-2.01 (m, 1H), 1.20 (d, J = 6.7 Hz, 3H), 0.90 (dd, J = 11.9, 6.7 Hz, 6H); LCMS: 549.05 357 2-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridine-3 -ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thiocarbamide (2-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 11.41 (t, J = 6.1 Hz, 1H), 8.62-8.59 (m, 2H), 8.45 (dd, J = 5.2, 2.1 Hz, 2H), 7.79 -7.74 (m, 3H), 7.34 (ddd, J = 7.8, 4.7, 0.8 Hz, 1H), 5.02 (d, J = 6.4 Hz, 2H), 4.73 (s, 4H), 4.12-4.06 (m, 1H ), 3.99 (d, J = 16.8 Hz, 1H); LCMS: 569.4 358 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( Trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.11 (d, J = 5.5 Hz, 1H), 8.63 (s, 1H), 8.05 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H ), 4.72 (s, 4H), 4.05 (dd, J = 43.9, 17.0 Hz, 2H), 2.21-2.19 (m, 1H), 1.39-1.33 (m, 1H), 1.21-1.16 (m, 1H); LCMS: 571.15 359 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 -Difluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thiocarbamide ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 11.03 (t, J = 6.1 Hz, 1H), 8.64 (d, J = 0.6 Hz, 1H), 8.48 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 6.36 (tt, J = 55.9, 4.3 Hz, 1H), 4.74 (s, 4H), 4.30-4.20 (m, 2H), 4.10 (d, J = 16.8 Hz, 1H), 3.99 (d, J = 16.8 Hz, 1H); LCMS: 542.35 360 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-thioamide (2-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine- 6-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 11.12 (t, J = 6.6 Hz, 1H), 8.65 (s, 1H), 8.47 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H ), 4.74 (s, 4H), 4.72-4.65 (m, 2H), 4.05 (dd, J = 44.5, 17.0 Hz, 2H); LCMS: 560.3 361 2-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(methoxy Methyl)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide (2-(5-( 3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(methoxymethyl)-N-(prop-2-yn-1-yl)-2, 3-dihydro-1H-pyrrolo[3,4-c]pyridine-6-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.60 (s, 1H), 7.74 (d, J = 6.1 Hz, 2H), 7.67 (s, 1H), 4.90 (s, 2H), 4.72 (d , J = 5.2 Hz, 4H), 4.31 (d, J = 2.4 Hz, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.95 (d, J = 16.8 Hz, 1H), 3.15-3.11 (m , 3H), 3.04-3.06 (1H); LCMS: 544.4 362 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3 -Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-ethyl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.81 (t, J = 5.3 Hz, 1H), 7.76 (d, J = 6.4 Hz, 2H), 4.50 (d, J = 58.4 Hz, 4H), 4.02 (dd, J = 43.6, 17.0 Hz, 2H), 3.69-3.62 (m, 2H), 2.22 (s, 3H), 1.20 (t, J = 7.2 Hz, 3H); LCMS: 524 363 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-thiocarbamide (5-(5-(3,5-dichloro-4 -fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole -2-carbothioamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.50 (s, 1H), 7.76 (d, J = 6.1 Hz, 2H), 7.67 (s, 1H), 4.68-4.59 (m, 4H), 4.48 (s, 2H), 4.01 (dd, J = 46.6, 17.0 Hz, 2H); LCMS: 566.33 364 N-cyclopropyl-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)- 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-formamide (N-cyclopropyl-6-(5-(3,5-dichloro-4-fluorophenyl)-5-( trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.89-8.86 (m, 2H), 7.76 (dd, J = 14.9, 6.4 Hz, 2H), 4.72 (s, 4H), 4.14 (d, J = 17.1 Hz, 1H), 4.01 (d, J = 17.1 Hz, 1H), 2.92-2.85 (m, 1H), 0.72-0.62 (m, 4H); LCMS: 503.4 365 N-(1-cyanocyclopropyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(1-cyanocyclopropyl)-6-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.86 (s, 1H), 8.94 (s, 1H), 7.79-7.75 (m, 2H), 4.74 (s, 4H), 4.15 (d, J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H), 1.56 (dd, J = 8.3, 5.4 Hz, 2H), 1.31 (dd, J = 8.4, 5.7 Hz, 2H); LCMS: 528.4 366 N-(cyclopropylmethyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3 -yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(cyclopropylmethyl)-6-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.97-8.92 (m, 2H), 7.78 (d, J = 6.1 Hz, 2H), 4.73 (s, 4H), 4.15 (d, J = 17.1 Hz , 1H), 4.02 (d, J = 17.1 Hz, 1H), 3.15 (t, J = 6.5 Hz, 2H), 1.08-1.01 (m, 1H), 0.43-0.39 (m, 2H), 0.25-0.22 ( m, 2H); LCMS: 517.45 367 N-(cyanomethyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3- Base)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(cyanomethyl)-6-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.59 (t, J = 5.9 Hz, 1H), 8.96 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.74 (s, 4H ), 4.31 (d, J = 5.9 Hz, 2H), 4.15 (d, J = 17.1 Hz, 1H), 4.06-4.00 (m, 1H); LCMS: 502.35 368 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2 ,2-trifluoroethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2,2,2-trifluoroethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.46 (t, J = 6.6 Hz, 1H), 8.96 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.75 (s, 4H ), 4.17-4.00 (m, 4H); LCMS: 545.9 369 (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-di Hydrogen-5H-pyrrolo[3,4-d]pyrimidin-2-yl)(3,3-difluoroazetidin-1-yl)methanone ((6-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)(3,3 -difluoroazetidin-1-yl)methanone) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.92 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.88 (t, J = 12.4 Hz, 2H), 4.73 (d, J = 5.2 Hz, 4H), 4.52 (t, J = 12.5 Hz, 2H), 4.14 (d, J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H); LCMS: 539.95 370 N-(1-cyanocyclobutyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(1-cyanocyclobutyl)-6-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.82 (s, 1H), 8.95 (s, 1H), 7.79 (d, J = 6.4 Hz, 2H), 4.75 (s, 4H), 4.15 (d , J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H), 2.70-2.63 (m, 2H), 2.57-2.51 (m, 2H), 2.08-1.97 (m, 2H); LCMS: 544.9 371 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1 ,3,3,3-pentafluoropropyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1,1,3,3,3-pentafluoropropyl)-6,7-dihydro-5H-pyrrolo[3 ,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.43 (t, J = 6.7 Hz, 1H), 8.96 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.75 (s, 4H ), 4.17-4.00 (m, 4H); LCMS: 595.3 372 6-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5- Methyl-1,3,4-oxadiazol-2-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((5-methyl-1,3,4-oxadiazol-2-yl )methyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.59 (t, J = 6.0 Hz, 1H), 8.95 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.74 (s, 4H ), 4.66 (d, J = 5.9 Hz, 2H), 4.15 (d, J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H), 2.45 (s, 3H); LCMS: 559.35 373 N-(2-cyclopentylethyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole -3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(2-cyclopentylethyl)-6-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, CHLOROFORM-D) δ 8.77 (s, 1H), 7.97 (s, 1H), 7.58 (d, J = 6.1 Hz, 2H), 4.78 (dd, J = 11.6, 1.8 Hz, 4H), 3.89 (d, J = 16.4 Hz, 1H), 3.56-3.46 (m, 3H), 1.87-1.80 (m, 3H), 1.67 (q, J = 7.2 Hz, 3H), 1.56-1.52 (m , 3H), 1.17-1.14 (m, 2H); LCMS: 561.3 374 N-(1-cyanocyclohexyl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole- 3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(1-cyanocyclohexyl)-6-(5-(3,5-dichloro -4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.01 (s, 1H), 8.94 (s, 1H), 7.79 (d, J = 6.1 Hz, 2H), 4.74 (s, 4H), 4.15 (d , J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H), 2.34 (d, J = 13.2 Hz, 2H), 1.83-1.77 (m, 2H), 1.73-1.68 (m, 2H) , 1.62-1.46 (m, 3H), 1.31-1.22 (m, 1H); LCMS: 570.4 375 N-(4-cyanotetrahydro-2H-pyran-4-yl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (N-(4-cyanotetrahydro-2H-pyran -4-yl)-6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-6,7-dihydro-5H-pyrrolo[ 3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.29 (s, 1H), 8.96 (s, 1H), 7.79 (d, J = 6.1 Hz, 2H), 4.75 (s, 4H), 4.15 (d , J = 17.1 Hz, 1H), 4.03 (d, J = 17.1 Hz, 1H), 3.87 (dt, J = 12.3, 3.9 Hz, 2H), 3.60-3.55 (m, 2H), 2.37-2.32 (m, 2H), 2.07-2.00 (m, 2H); LCMS: 573 376 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-methyl Tetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(4-methyltetrahydro-2H-pyran-4-yl)-6,7-dihydro-5H-pyrrolo[ 3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 8.91 (s, 1H), 8.18 (s, 1H), 7.78 (d, J = 6.4 Hz, 2H), 4.73 (s, 4H), 4.14 (d , J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H), 3.63 (dt, J = 11.8, 4.4 Hz, 2H), 3.51 (t, J = 9.7 Hz, 2H), 2.19 (d , J = 13.9 Hz, 2H), 1.64-1.57 (m, 2H), 1.41 (s, 3H); LCMS: 561.45 377 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-( Trifluoromethyl)cyclopropyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-(trifluoromethyl)cyclopropyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2 -carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.25 (d, J = 5.4 Hz, 1H), 8.92 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.73 (d, J = 4.6 Hz, 4H), 4.14 (d, J = 17.1 Hz, 1H), 4.01 (d, J = 17.1 Hz, 1H), 2.22-2.18 (m, 1H), 1.37-1.32 (m, 1H), 1.24 -1.19 (m, 1H); LCMS: 571.35 378 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( (Trifluoromethyl)sulfonyl)azetidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((trifluoromethyl)sulfonyl)azetidin-3-yl)-6 ,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.82 (d, J = 7.6 Hz, 1H), 8.96 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.96-4.88 (m , 1H), 4.74 (d, J = 4.9 Hz, 4H), 4.45 (t, J = 7.5 Hz, 4H), 4.15 (d, J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H ); LCMS: 650.3 379 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-( (Difluoromethyl)sulfonyl)azetidin-3-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-( 5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(1-((difluoromethyl)sulfonyl)azetidin-3-yl)-6 ,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.74 (d, J = 7.3 Hz, 1H), 8.95 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 7.16 (t, J = 52.3 Hz, 1H), 4.89-4.73 (m, 5H), 4.36-4.28 (m, 4H), 4.15 (d, J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H); LCMS : 632.3 380 6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methoxy- 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide (6-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4 ,5-dihydroisoxazol-3-yl)-N-methoxy-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carboxamide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 12.16 (s, 1H), 8.90 (s, 1H), 7.78 (d, J = 6.1 Hz, 2H), 4.72 (s, 4H), 4.14 (d , J = 17.1 Hz, 1H), 4.02 (d, J = 17.1 Hz, 1H), 3.70 (s, 3H); LCMS: 493.4 381 N'-benzoyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (N'-benzoyl-5-(5-(3,5-dichloro-4-fluorophenyl)- 5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.51 (d, J = 11.5 Hz, 2H), 7.89 (d, J = 7.3 Hz, 2H), 7.78-7.73 (m, 3H), 7.58 (d , J = 7.6 Hz, 1H), 7.51 (t, J = 7.5 Hz, 2H), 4.64 (s, 2H), 4.52 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d , J = 16.9 Hz, 1H), 1.22 (s, 1H); LCMS:586.7 382 N'-Acetyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (N'-acetyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5 -(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.28 (s, 1H), 9.85 (s, 1H), 8.00 (s, 0H), 7.89 (d, J = 6.4 Hz, 0H), 7.76 (d , J = 6.4 Hz, 2H), 7.66 (s, 1H), 4.62 (s, 2H), 4.51 (d, J = 14.7 Hz, 2H), 4.07 (d, J = 17.1 Hz, 1H), 3.95 (d , J = 17.1 Hz, 1H), 1.91 (d, J = 14.7 Hz, 3H); LCMS:522.75 383 N'-benzoyl-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl )-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (N'-benzoyl-5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.47 (s, 1H), 10.05 (s, 1H), 7.91-7.89 (m, 2H), 7.77 (d, J = 6.4 Hz, 2H), 7.59 (t, J = 7.5 Hz, 1H), 7.51 (t, J = 7.3 Hz, 2H), 4.55 (d, J = 58.7 Hz, 4H), 4.03 (dd, J = 43.5, 17.1 Hz, 2H), 2.37 (s, 3H); LCMS: 601 384 5-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-pivalyl -5,6-Dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl)-N'-pivaloyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.23 (s, 1H), 9.54 (s, 1H), 7.76 (d, J = 6.4 Hz, 2H), 7.67 (s, 1H), 4.56 (d , J = 49.6 Hz, 4H), 4.07 (d, J = 16.9 Hz, 1H), 3.95 (d, J = 16.6 Hz, 1H), 1.16 (s, 9H); LCMS:568.2 385 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4- Tolyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl) -5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methylbenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.49 (s, 1H), 10.42 (s, 1H), 7.81-7.73 (m, 5H), 7.31 (d, J = 8.1 Hz, 2H), 4.64 (s, 2H), 4.52 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d, J = 16.9 Hz, 1H), 2.37 (s, 3H); LCMS: 600.95 386 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3, 5-difluorobenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide (5-(5-(3,5 -dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3,5-difluorobenzoyl)-3-methyl-5,6-dihydro-4H-thieno[ 2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.68 (s, 1H), 10.17 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.60-7.52 (m, 3H), 4.63 (s, 2H), 4.48 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.97 (d, J = 16.8 Hz, 1H), 2.36 (s, 3H); LCMS:636.5 387 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4- Methoxybenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methoxybenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3 -c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.32 (s, 1H), 9.97 (s, 1H), 7.88 (d, J = 9.0 Hz, 2H), 7.77 (d, J = 6.1 Hz, 2H ), 7.04 (d, J = 9.0 Hz, 2H), 4.63 (s, 2H), 4.48 (s, 2H), 4.03 (dd, J = 43.8, 17.1 Hz, 2H), 3.84 (d, J = 13.7 Hz , 3H), 2.36 (s, 3H); LCMS:632.95 388 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N '-(5-methylthiophene-2-carbonyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide (5-(5-(3,5- dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-N'-(5-methylthiophene-2-carbonyl)-5,6-dihydro-4H-thieno [2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.37 (s, 1H), 10.00 (s, 1H), 7.77 (d, J = 6.4 Hz, 2H), 7.66 (d, J = 3.7 Hz, 1H ), 6.89 (d, J = 2.7 Hz, 1H), 4.62 (s, 2H), 4.47 (s, 2H), 4.02 (dd, J = 43.5, 16.9 Hz, 2H), 2.35 (s, 3H); LCMS :620.9 389 N'-(2-cyclopropylacetyl)-5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroiso Oxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (N'-(2-cyclopropylacetyl)-5- (5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3-methyl-5,6-dihydro-4H-thieno[2,3- c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.84 (s, 1H), 9.76 (s, 1H), 7.76 (d, J = 6.1 Hz, 2H), 4.61 (s, 2H), 4.46 (s , 2H), 4.02 (dd, J = 43.9, 17.0 Hz, 2H), 2.67-2.65 (m, 1H), 2.32 (s, 4H), 2.07 (d, J = 6.8 Hz, 2H), 0.97 (d, J = 8.3 Hz, 1H), 0.45 (dd, J = 12.2, 5.6 Hz, 2H), 0.17 (d, J = 5.1 Hz, 2H); LCMS:580.4 390 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-isobutyryl- 3-Methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl)-5- (trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-isobutyryl-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 9.79 (d, J = 10.3 Hz, 2H), 7.76 (d, J = 6.4 Hz, 2H), 4.53 (d, J = 59.2 Hz, 4H), 4.02 (dd, J = 44.0, 17.1 Hz, 2H), 2.66 (d, J = 2.0 Hz, 1H), 2.32 (s, 4H), 1.05 (d, J = 6.6 Hz, 6H); LCMS:566.9 391 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(2- Fluorobenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide (5-(5-(3,5-dichloro- 4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(2-fluorobenzoyl)-3-methyl-5,6-dihydro-4H-thieno[2,3-c ]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.30 (s, 1H), 10.13 (s, 1H), 7.77 (d, J = 6.1 Hz, 2H), 7.67-7.59 (m, 2H), 7.35 -7.30 (m, 2H), 4.55 (d, J = 60.4 Hz, 4H), 4.10-3.99 (m, 2H), 2.36 (s, 3H); LCMS:618.75 392 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3, 5-difluorobenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4- fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(3,5-difluorobenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2 -carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.72 (s, 1H), 10.66 (s, 1H), 7.79 (d, J = 6.1 Hz, 2H), 7.75 (s, 1H), 7.61 (d , J = 5.6 Hz, 2H), 7.58-7.55 (m, 1H), 4.66-4.54 (m, 4H), 4.10 (d, J = 17.4 Hz, 1H), 3.98 (d, J = 17.1 Hz, 1H) ; LCMS: 622.75 393 5-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4- Methoxybenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazine (5-(5-(3,5-dichloro-4-fluorophenyl )-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(4-methoxybenzoyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carbohydrazide) ¹ H-NMR (400 MHz, DMSO- d ₆ ) δ 10.45 (s, 1H), 10.35 (s, 1H), 7.88 (d, J = 8.9 Hz, 2H), 7.77 (d, J = 6.1 Hz, 2H ), 7.73 (s, 1H), 7.04 (d, J = 9.2 Hz, 2H), 4.64 (s, 2H), 4.52 (s, 2H), 4.08 (d, J = 17.1 Hz, 1H), 3.96 (d , J = 17.1 Hz, 1H), 3.82 (s, 3H); LCMS:616.85 394 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-methyl-5,6-di Hydrogen-4H-pyrrolo[3,4-d]thiazole-2-carboxamide (5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl) -N-methyl-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole-2-carboxamide) LCMS:464.01 * Compound names were generated using Chemdraw Professional 19.1

As described herein, compounds of formula (I) have been shown to exert insecticidal activity against a variety of insects that attack important agricultural crops. The activity of the compounds of the invention is assessed by as described in the following assays:

Biological example:

example A : Tomato Moth ( Helicoverpa armigera )

Use the diet incorporation method, in which the required amount of test compound is weighed out and dissolved in a test tube containing a solvent solution. Place the tubes in a vortex at 2000 rpm for 90 min for proper mixing. When the temperature in the bioassay vessel is approximately 50 °C, add the semi-synthetic feed to this solution. Stir compound and feed well for proper mixing and allow to cool for 30 minutes. The solidified feed was cut into aliquots, and each aliquot was transferred to one of the cells of the bioassay tray. Release a single starved third instar larva into each cell of the bioassay tray and cover the assay tray with a lid. The bioassay trays were then maintained under laboratory conditions at a temperature of 25 °C and a relative humidity of 70%. Dead, moribund and surviving larvae were recorded 96 hours after larval release. The calculated percent mortality was obtained by combining the percent mortality of dead and dying larvae and comparing it to one of the untreated ones. The following compounds were reported as having a mortality rate greater than or equal to 70% at 300 ppm: 1, 2, 4, 5, 7, 8, 9, 11, 12, 13, 15, 16, 17, 20, 22, 28, 36, 38, 39, 42, 45, 47, 49, 50, 54, 65, 67, 69, 72, 73, 75, 76, 80, 82, 83, 84, 85, 86, 88, 90, 94, 95, 96, 97, 98, 104, 105, 106, 107, 115, 116, 118, 126, 133, 134, 137, 139, 144, 145, 149, 150, 152, 161, 162, 172, 174, 185, 187, 188, 190, 192, 193, 194, 195, 197, 198, 205, 210, 216, 218, 220, 225, 240, 242, 243, 245, 246, 249, 250, 251, 252, 253, 254, 264, 265, 266, 267, 268, 269, 271, 276, 277, 280, 281, 282, 285, 286, 288, 290, 294, 295, 296, 297, 298, 301, 302, 303, 304, 305, 306, 307, 309, 310, 311, 312, 319, 322, 324, 327, 332, 334, 336, 338, 339, 341, 342, 345, 348, 350, 352, 353, 354, 355, 356, 358, 359, 361, 362, 363 and 369.

example B : Spodoptera litura ( Spodoptera litura )

The feed incorporation method is used, in which the required amount of the test compound is weighed and dissolved in a test tube containing a solvent solution. Place the tubes in a vortex at 2000 rpm for 90 min for proper mixing. When the temperature in the bioassay vessel is approximately 50 °C, add the semi-synthetic feed to this solution. Stir compound and feed well for proper mixing and allow to cool for 30 minutes. The solidified feed was cut into aliquots, and each aliquot was transferred to one of the cells of the bioassay tray. Release a single starved third instar larva into each cell of the bioassay tray and cover the assay tray with a lid. The bioassay trays were then maintained under laboratory conditions at a temperature of 25 °C and a relative humidity of 70%. Dead, moribund and surviving larvae were recorded 96 hours after larval release. The calculated percent mortality was obtained by combining the percent mortality of dead and dying larvae and comparing it to one of the untreated ones. The following compounds were reported as having a mortality rate greater than or equal to 70% at 300 ppm: 1, 2, 4, 7, 9, 11, 12, 13, 15, 16, 17, 31, 33, 36, 39, 45, 53, 54, 61, 63, 65, 67, 68, 69, 70, 71, 72, 73, 75, 76, 79, 80, 81, 82, 83, 84, 85, 86, 88, 89, 90, 91, 94, 95, 96, 97, 104, 105, 106, 107, 108, 112, 115, 116, 118, 119, 120, 121, 123, 125, 126, 127, 128, 129, 133, 134, 135, 137, 139, 144, 145, 146, 148, 149, 150, 152, 153, 161, 162, 169, 172, 184, 185, 187, 188, 190, 192, 193, 194, 195, 197, 198, 204, 210, 213, 216, 217, 218, 220, 221, 223, 225, 227, 228, 229, 237, 242, 243, 244, 245, 246, 247, 249, 250, 251, 252, 253, 254, 256, 262, 264, 266, 267, 268, 269, 271, 277, 280, 281, 282, 283, 285, 286, 288, 290, 292, 293, 294, 295, 296, 297, 298, 301, 302, 303, 304, 305, 306, 309, 310, 311, 312, 315, 316, 317, 318, 319, 321, 324, 327, 329, 332, 334, 336, 337, 339, 341, 342, 345, 348, 352, 353, 354, 355, 356, 357, 358, 359, 361 and 377.

example C : diamondback moth ( Plutella xylostella )

Tests are performed using the leaf dip method, in which the desired amount of compound is weighed and dissolved in a test tube containing a solvent solution. The tubes were placed in a vortex at 2000 rpm for 90 minutes for proper mixing and then diluted to the desired assay concentration with 0.01% Triton-X solution. Immerse cabbage leaves in the compound solution for 10 s, dry in the shade for 20 min, and transfer to the cells of the bioassay tray. Release a single starved second instar larvae into each cell of the bioassay tray and cover the assay tray with a lid. The bioassay trays were then maintained under laboratory conditions at a temperature of 25 °C and a relative humidity of 70%. Dead, moribund and surviving larvae were recorded 72 hours after larval release. The calculated percent mortality was obtained by combining the percent mortality of dead and dying larvae and comparing it to one of the untreated ones. The following compounds were reported as having a mortality rate greater than or equal to 70% at 300 ppm: 1, 2, 3, 4, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28, 29, 30, 31, 33, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 100, 101, 102, 103, 104, 105, 106, 107, 108, 111, 112, 113, 114, 115, 116, 118, 119, 120, 121, 122, 123, 125, 126, 127, 128, 129, 133, 134, 135, 137, 139, 140, 141, 142, 144, 145, 146, 147, 149, 150, 152, 153, 158, 159, 160, 161, 162, 163, 164, 167, 168, 169, 170, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 205, 208, 210, 211, 213, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 228, 229, 231, 233, 236, 237, 240, 241, 242, 243, 244, 245, 246, 247, 249, 250, 251, 252, 253, 254, 256, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 276, 277, 280, 281, 283, 284, 285, 286, 288, 290, 291, 292, 293, 294, 295, 296, 297, 298, 301, 302, 303, 304, 305, 306, 308, 309, 310, 312, 314, 315, 316, 317, 318, 319, 321, 322, 324, 326, 327, 329, 332, 333, 335, 336, 337, 338, 339, 340, 341, 342, 345, 346, 348, 350, 352, 353, 354, 355, 356, 357, 358, 359, 360 and 362.

example D. : Brown rice lice ( Nilaparvata lugens )

Tests are performed using the seedling dip method, in which the desired amount of compound is weighed and dissolved in a test tube containing a solvent solution. The tubes were placed in a vortex at 2000 rpm for 90 minutes for proper mixing and then diluted to the desired assay concentration with 0.01% Triton-X solution. Rice (paddy) seedlings were immersed in the compound solution for 10 seconds, dried in the shade for 20 minutes, and then the seedlings were placed in glass test tubes and the roots were kept in water. Fifteen third-instar nymphs were released into each test tube and the tubes were stored in a plant growth chamber at 25 °C and 75% relative humidity. Dead, moribund and surviving nymphs were recorded 72 hours after nymph release. The calculated percent mortality was obtained by combining the percent mortality of dead and dying nymphs and comparing it to one of the untreated ones. The following compounds were reported as having a mortality rate greater than or equal to 70% at 300 ppm: 199, 200, 202, 203, 204, 205, 210, 211, 212, 213, 214, 215, and 228.

While the invention has been described in terms of certain preferred embodiments, other embodiments will be apparent to those of ordinary skill in the art to which the subject matter pertains in view of the specification. It will be apparent to those of ordinary skill in the art that various modifications in the materials and methods can be made without departing from the scope of the invention.

Claims (23)

A compound of formula (I), Formula (I) wherein, R ¹ is selected from the group consisting of: C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl and C ₃ - C ₆ -halocycloalkyl; Cy is selected from the group consisting of phenyl and C ₅ -C ₆ -heterocyclyl, which may be optionally substituted by one or more R ² groups; wherein , R ² is selected from the group consisting of hydrogen, halogen, nitrile, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ - C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl and C ₃ -C ₈ -cycloalkyl; ring Q represents a C ₅ -C ₆ -heterocyclyl, which can optionally be replaced by one or more Each R ³ group is substituted; R ³ is selected from the group consisting of hydrogen, halogen, nitrile, nitro, C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkenyl, C ₂ - C ₆ -alkynyl, C ₁ -C ₄ -haloalkyl, C ₂ -C ₄ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, C ₃ -C ₄ -cycloalkyl, C ₃ -C ₅ -heterocyclyl, -OC ₃ -C ₄ -heterocyclyl, SCN, SF ₅ , NR'R'', OR', S(O) _n R' and CR'=NR''; A is selected from The group consisting of: -CR ^a R ^b -and -C(=W)-; W is selected from the following group: O, S or NR ⁹ ; R ⁹ is selected from the group consisting of: hydrogen , halogen, nitrile, OR', C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl and C ₃ -C ₈ -cycloalkyl; R ^a and R ^b are independently selected from the group consisting of hydrogen, halogen, nitrile, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl and C ₃ -C ₈ -cycloalkyl; D is selected from the group consisting of: NR ⁵ R ⁶ , -N=S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), C ₆ -C ₁₀ -Aryl and C ₃ -C ₁₀ -heterocyclyl; wherein, the aryl and the heterocyclyl are optionally substituted by one or more R ^D groups; R ^D is selected from the group consisting of Groups: Halogen, CN, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -halogen Alkenyl, C ₂ -C ₆ -haloalkynyl, OR ⁴ , C ₁ -C ₆ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₆ -alkyl-C(= O)-R'', NR'R'', C ₁ -C ₆ -alkyl-NR'R'', C(=O)-NR'R'', C ₁ -C ₆ -alkyl-C (=O)-NR′R′′, S(O) _n R′′, C ₁ -C ₆ -alkyl-S(O) _n R′′, CR′=NR′′, C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl and Si(R') ₃ ; R ⁴ is selected from the group consisting of hydrogen, C ₁ -C ₆ -Alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₃ -C ₈ -cycloalkane radical, C(=O)-R′′, C ₁ -C ₆ -alkyl-C(=O)-R′′, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl and C ₃ -C ₈ -heterocyclyl; wherein each R ⁴ group is optionally substituted by one or more groups selected from the group consisting of: halogen, CN, R '', OR'', SR'', N(R'R'') and Si(R') ₃ ; R ⁵ is selected from the group consisting of: C ₁ -C ₈ -alkyl, C ₁ -C ₈ -cyanoalkyl, C ₂ -C ₈ -alkenyl, C ₂ -C ₈ -alkynyl, C ₁ -C ₈ -haloalkyl, C ₂ -C ₈ -haloalkenyl, C ₂ - C ₈ -haloalkynyl, OR ⁴ , C ₁ -C ₈ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₈ -alkyl-C(=O)-R′′ , NR′R′′, C ₁ -C ₆ -Alkyl-NR′R′′, C(=O)-NR′R′′, C ₁ -C ₈ -Alkyl-C(=O)-NR 'R'', C ₂ -C ₆ -alkenyl-C(=O)-N(R'R''), C ₁ -C ₈ -alkyl-S(O) _n R ⁴ , S(O) _n R ⁴ , CR′=NR′′, C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -nitrile cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alk C ₃ -C ₈ -cyanocycloalkyl-C ₁ -C ₈ -alkyl, C ₄ -C ₈ -cycloalkenyl, C ₄ -C ₈ -cycloalkynyl, bicyclic C ₅ -C ₁₂ - Alkyl, bicyclic C ₇ -C ₁₂ -alkenyl, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein each group is optionally substituted by one or more R ^5a groups; R ^5a is selected from the group consisting of Groups: halogen, CN, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ - Haloalkenyl, C ₂ -C ₆ -haloalkynyl, OR ⁴ , C ₁ -C ₆ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₆ -alkyl-C( =O)-R'', NR'R'', C ₁ -C ₆ -Alkyl-NR'R'', C(=O)-NR'R'', C ₁ -C ₆ -Alkyl- C(=O)-NR′R′′, S(O) _n R′′, C ₁ -C ₆ -alkyl-S(O) _n R′′, CR′=NR′′, C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₆ -alkyl and Si(R') ₃ ; R ⁶ is selected from the group consisting of hydrogen, C ₁ -C ₈ -Alkyl, C ₂ -C ₈ -alkenyl, C ₂ -C ₈ -alkynyl, C ₁ -C ₈ -haloalkyl, C ₂ -C ₈ -haloalkenyl, C ₂ -C ₈ -halogenyl Alkynyl, OR ⁴ , C ₁ -C ₆ -alkyl-OR ⁴ , C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl, Si(R ') ₃ and (C=O)-R''; or the R ⁵ and R ⁶ substituents and the atoms to which they are attached or together with other atoms may form a three to seven membered ring selected from the group consisting of Group: C, N, O, S, and optionally includes 1 to 3 selected from the group consisting of C(=O), C(=S), S(O) _0-2 and Si(R′) ₂ The ring members of the group (ring members), the part of the three to seven membered ring is selectively substituted by one or more R ⁷ groups; R ⁷ is selected from the group consisting of: halogen, nitrile , SCN, Nitro, C ₁ -C ₆ -Alkyl, C ₂ -C ₆ -Alkenyl, C ₂ -C ₆ -Alkynyl, C ₁ -C ₆ -Haloalkyl, C ₂ -C ₆ -Halo Alkenyl, C ₂ -C ₆ -haloalkynyl, SF ₅ , OR ⁴ , C ₁ -C ₈ -alkyl-OR ⁴ , NR′R′′, C ₁ -C ₈ -alkyl-NR′R′ ′, Si(R′) ₃ , (C=O)-R′′, C ₁ -C ₈ -alkyl-(C=O)-R′′, S(O) _n R′′, C ₁ - C ₈ -Alkyl-S(O) _n R'', CR'=NR'', C ₃ -C ₈ -cycloalkyl and C ₃ -C ₈ -cycloalkyl-C ₁ -C ₄ -alkyl or, two R ⁷ substituents can form a three- to six-membered ring together with the atoms to which they are attached or with other atoms selected from the group consisting of C, N, O, S, and selected optionally comprising 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O) _0-2 and Si(R') ₂ , the three to six membered ring A portion of is optionally substituted with one or more groups selected from the group consisting of halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; or, R ⁵ and R ⁶ substituents and the atoms connected to them can form together -N=S(O) _0-1 R ^8a R ^8b group; R ^8a is selected from the following The group formed by: C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -halogenyl Alkenyl, C ₃ -C ₈ -cycloalkyl, C ₁ -C ₆ -alkyl-C(=O)-R′′, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl- C ₁ -C ₆ -alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein each R ^8a group is optionally Substituted by one or more groups selected from the group consisting of: Halogen, CN, R'', OR'', S(O) _0-2 R'', NR'R'', Si(R') ₃ , COOR' and CON(R') ₂ ; R ^8b is selected from the group consisting of: C ₁ -C ₆ -alkyl or C ₃ -C ₆ -cycloalkyl; or R ^8a and R ^8b substituents Atoms attached thereto or together with other atoms may form a three to six membered ring selected from the group consisting of: C, N, O, S, and optionally contain 1 to 3 members selected from Ring members of the group consisting of C(=O), C(=S), S(O) _0-2 , and Si(R') ₂ , portions of the three- to six-membered rings can be selectively selected Substituted by one or more groups consisting of: halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; each R ² , R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ groups may be optionally substituted by one or more groups selected from the group consisting of: halogen, CN, R′′, OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R'';R' is selected from the group consisting of hydrogen, C ₁ -C ₆ - Alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl and C ₃ -C ₈ -cycloalkyl; wherein the alkyl, the alkenyl and the cycloalkyl are optionally Substituted by one or more halogens; R'' is selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₈ -cycloalkyl, N(R′) ₂ , OR′, phenyl, benzyl and C ₃ -C ₈ -heterocyclyl; each R The '' group can be optionally substituted by one or more groups selected from the group consisting of: halogen, R', CN, OR', SR', N(R') ₂ , Si(R') ₃ , COOR' and CON(R') ₂ ; m and n represent integers 0, 1 or 2; p and q represent integers 0, 1 or 2; provided that p and q cannot represent integers 0 at the same time; or are agriculturally acceptable Salts, stereoisomers, diastereomers, enantiomers, tautomers, metal complexes, polymorphs or N-oxides of . The compound of formula (I) as claimed in item 1, wherein, the Snippets are selected from the group consisting of: , . The compound of formula (I) as claimed in item 1 or 2, wherein, the compound of formula (I) is represented by a compound of formula (la); Formula (la) wherein, the R ¹ substituent is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are hydrogen or halogen, and A and D are as defined in Claim 1. The compound of formula (I) as described in Claim 1, 2 or 3, wherein A represents -C(=W)-, wherein W is as defined in Claim 1. The formula (I) compound as described in claim item 1 or 2 or 3, wherein, A represents bond (bond), and this formula (Ia-1) or its salt, Formula (Ia-1) wherein, the R ¹ substituent is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are hydrogen or halogen, and the R ³ and D substituents are as described in Claim 1 definition. The compound of formula (I) as described in claim 1 or 2 or 3, wherein, A represents -C(=W)-, and the compound of formula (I) is represented by a compound of formula (la-2); Formula (la-2) wherein, R ¹ , R ^2a , R ^2b , R ^2c , R ³ , W and D are as defined in Claim 1. The compound of formula (I) as described in Claim 6, wherein, A represents -C(=W)-, D represents NR ⁵ R ⁶ , and the compound of formula (I) is represented by a compound of formula (la-2-1) ; Formula (la-2-1) wherein, R ¹ is C ₁ -C ₆ -haloalkyl; R ^2a , R ^2b and R ^2c are selected from hydrogen or halogen; Ring Q is selected from the group consisting of: Thienyl (thienyl), pyridinyl (pyridinyl), pyrimidinyl (pyrimidinyl), pyrazinyl (pryazinyl) or thiazolyl (thiazolyl), which is optionally substituted by one or more ^R3 groups; ^R3 is selected from the group consisting of: halogen, nitrile, C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkenyl, C ₂ -C ₆ -alkynyl, C ₃ -C ₄ -cycloalkane and OR'; wherein, R ³ is optionally substituted by one or more halogen, OR' or nitrile; R ⁵ is selected from the group consisting of: C ₁ -C ₈ -alkyl, C ₁ -C ₈ -cyanoalkyl, C ₂ -C ₈ -alkenyl, C ₂ -C ₈ -alkynyl, C ₁ -C ₈ -haloalkyl, C ₂ -C ₈ -haloalkenyl, C ₂ -C ₈ -haloalkynyl, OR ⁴ , C ₁ -C ₈ -alkyl-OR ⁴ , C(=O)-R′′, C ₁ -C ₈ -alkyl-C(=O)-R′ ', NR'R'', NR'-C(=O)-R', C ₁ -C ₆ -alkyl-NR'R'', C(=O)-NR'R'', C ₁ - C ₈ -Alkyl-C(=O)-NR′R′′, C ₂ -C ₆ -Alkenyl-C(=O)-N(R′R′′), C ₁ -C ₈ -Alkyl -S(O) _n R ⁴ , S(O) _n R ⁴ , CR′=NR′′, C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cyanocycloalkyl, C ₃ -C ₈ -cycloalkyl-C ₁ -C ₈ -alkyl, C ₃ -C ₈ -nitrile cycloalkyl-C ₁ -C ₈ -alkyl, C ₄ -C ₈ -cycloalkenyl, C ₄ -C ₈ -Cycloalkynyl, bicyclic C ₅ -C ₁₂ -alkyl, bicyclic C ₇ -C ₁₂ -alkenyl, C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ - Alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein, R ⁵ can be optionally selected from one or Multiple group substitutions: halogen, CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; R ⁴ is selected from the following The group formed by: hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₃ -C ₈ -cycloalkyl, C(=O)-R′′, C ₁ -C ₆ -alkyl-C(=O)-R′′, COOR′, C ₆ - C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl and C ₃ -C ₈ -heterocyclyl; wherein each R ⁴ group is optionally selected from Substituted by one or more groups: halogen, CN, R'', OR'', SR'', N(R'R'') and Si(R') ₃ ; R ⁶ is selected from the following Group of constituents: hydrogen, C ₁ -C ₆ -alkyl, OR ⁴ , C ₁ -C ₄ -alkyl-OR ⁴ , C ₃ -C ₈ -cycloalkyl, C ₃ -C ₈ -cycloalkyl -C ₁ -C ₄ -Alkyl, Si(R') ₃ and (C=O)-R''; wherein, R ⁶ is optionally substituted by one or more halogen or nitrile groups; R ⁵ and The R ^substituent and the atom to which it is attached or together with other atoms may form a three to seven membered ring selected from the group consisting of: C, N, O, S, and optionally comprising 1 to 3 ring members selected from the group consisting of C(=O), C(=S), S(O) _0-2 and Si(R') ₂ , part of the three to seven membered ring is optional is substituted by one or more R ⁷ groups; R ⁷ is selected from the group consisting of halogen, nitrile, nitro, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, OR ⁴ , C ₁ -C ₈ -alkyl -OR ⁴ , NR′R′′, C ₁ -C ₈ -alkyl-NR′R′′, Si(R′) ₃ , (C=O)-R′′, C ₁ -C ₈ -alkyl -(C=O)-R'', S(O) _n R'', C ₁ -C ₈ -alkyl-S(O) _n R'', CR'=NR'' and C ₃ -C ₈ -cycloalkyl C ₃ -C ₈ -cycloalkyl; wherein the R ⁷ group is optionally substituted by one or more groups selected from the group consisting of: halogen, CN, R'', OR'',SR'',NR'R'',Si(R') ₃ , COOR' and CONR'R''; or, two R ⁷ substituents can form three to A six-membered ring, the other atoms are selected from the group consisting of C, N, O, S, and optionally contain 1 to 3 atoms selected from the group consisting of C(=O), C(=S), S( Ring members of the group consisting of O) _0-2 and Si(R') ₂ , part of the three to six membered rings may be optionally substituted by one or more groups selected from the group consisting of: halogen , CN, R'', OR'', SR'', NR'R'', Si(R') ₃ , COOR' and CONR'R''; or, the substituents R ⁵ and R ⁶ are connected to The atoms may together form a N=S(O) _0-1 R ^8a R ^8b group; R ^8a is selected from the group consisting of: C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl, C ₃ -C ₈ -cycloalkyl, C ₁ -C ₆ -alkyl-C( =O)-R'', C ₆ -C ₁₀ -aryl, C ₆ -C ₁₀ -aryl-C ₁ -C ₆ -alkyl, C ₃ -C ₈ -heterocyclyl and C ₃ -C ₈ -heterocyclyl-C ₁ -C ₆ -alkyl; wherein each R ^8a group is optionally substituted by one or more groups selected from the group consisting of: halogen, CN, R′′, OR '', SR'', NR'R'', Si(R') ₃ , COOR' and CON(R') ₂ ; R ^8b is selected from the group consisting of: C ₁ -C ₆ -alkyl and C ₃ -C ₆ -cycloalkyl; R' is selected from the group consisting of hydrogen, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl and C ₃ -C ₈ -cyclo Alkyl; wherein, the alkyl, the alkenyl and the cycloalkyl are optionally substituted by one or more halogens; R'' is selected from the group consisting of hydrogen, C ₁ -C ₆ -Alkyl, C ₂ -C ₆ -alkenyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₈ -cycloalkyl, N(R′) ₂ , OR′, phenyl, benzyl and C ₃ -C ₈ -heterocyclyl; each R'' group is optionally substituted by one or more groups selected from the group consisting of: halogen, R', CN, OR', SR', N(R') ₂ , Si(R') ₃ , COOR' and CON(R') ₂ ; W is selected from the group consisting of O, S and NR ⁹ ; or an agriculturally acceptable salt thereof , stereoisomer, diastereomer, enantiomer, tautomer, metal complex, polymorph or N-oxide. The compound of formula (I) as described in claim 1, wherein A represents -CR ^a R ^b -, wherein R ^a and R ^b are as defined in claim 1. The compound of formula (I) as described in any one of claims 2 to 8, wherein D is selected from the group consisting of: NR ⁵ R ⁶ , -N=S(O) _0-1 R ^8a R ^8b , OR ⁴ , S(O) _n R ⁵ , —S(O) _0-1 R ^8a (=NR ^8a ), phenyl and C ₃ -C ₈ -heterocyclyl. The compound of formula (I) as claimed in claim 1 or 2, wherein -AD group is selected from the group consisting of: -N=S(O) _0-1 R ^8a R ^8b , -OR ⁴ , -S(O) _n R ⁵ , -S(O) _0-1 R ^8a (=NR ^8a ), -S(O) _n C ₁ -C ₆ -alkyl-C(=O)-R′′, -C(=O)NR ⁶ C ₁ -C ₈ -alkyl, -C(=O)NR ⁶ C ₃ -C ₆ -cycloalkyl, -C(=O)NR ⁶ CR′=NR′′, -C(=O)NR ⁶ CR ^a R ^b C(=O)NR′R′′, -C(=O)NR ⁶ CR ^a R ^b C(=O)OR′, -C(=O)NR ⁶ C ₃ -C ₈ -heterocyclyl-C(=O)NR ⁶ CR ^a R ^b C ₃ -C ₈ -heterocyclyl, -C(=O)NR ⁶ (CR ^a R ^b ) ₂ OR ⁴ , -C(=O)NR ⁶ (CR ^a R ^b ) ₂ S(O) _n R′′, -C(=O)NR ₆ C ₃ -C ₈ -heterocyclyl-S(O) _n R′′ , -CR ^a R ^b -NR ⁶ C(=O)R'' and -CR ^a R ^b C ₃ -C ₈ -heterocyclic group; wherein, the cyclic group can be optionally replaced by one or more groups The group R ^D is substituted; wherein, R ¹ , R ² , R ³ , R ^a , R ^b , R ⁴ , R ⁵ , R ⁶ , R ⁸ , R′, R′′ and R ^D are as defined in Claim 1 . A composition comprising the compound of formula (I) as described in Claim 1 or its agronomically acceptable salt, stereoisomer, diastereoisomer, mirror-image isomer, tautomer, metalloisomer compounds, polymorphs or N-oxides and at least one additional component selected from the group consisting of surfactants and auxiliary agents. The composition as claimed in claim 11, wherein the composition further comprises at least one biologically active compatible compound selected from the group consisting of fungicides, insecticides, nematicides, and acaricides , biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers or nutrients. The composition as claimed in item 11, wherein the compound of formula (I) is from 0.1% to 99% by weight relative to the total weight of the composition. A combination comprising a biologically effective amount of one of the compounds of formula (I) as claimed in claim 1 and at least one additional bioactive compatible compound selected from the group consisting of fungicides, insecticides, nematocides, Acaricides, biopesticides, herbicides, plant growth regulators, antibiotics, fertilizers and nutrients. A method of controlling insect and acarid pests, comprising causing insect and acarid pests, their habitats, breeding grounds, food supplies, plants, seeds, soil, areas, materials, or conditions in which insect and acarid pests are growing or likely to grow Environment, or protected from pest attack or infection material, plant, seed, soil, surface or space with a biologically effective amount of the compound of formula (I) as described in claim item 1, 11 or 14, its Agronomically acceptable salts, stereoisomers, diastereomers, enantiomers, tautomers, polymorphs, metal complexes, N-oxides, compositions or combinations thereof . A method for protecting crops from insect and acarid attack or infection, comprising: making the crops with the compound of formula (I) as described in claim 1, 11 or 14, its agronomically acceptable salt, stereoisomer Species, diastereomers, enantiomers, tautomers, polymorphs, metal complexes, N-oxides, compositions, or combinations thereof. The method as claimed in claim 15 or 16, wherein the method comprises: applying an effective dosage of the compound of formula (I) to agricultural or horticultural crops, the effective dosage is 1 gram of active ingredient (gai) to 5000 g of active ingredient. A method for protecting seeds, plants and plant parts from soil insects and protecting seedling roots and shoots from soil and foliar insects, comprising: before sowing and/or after pre-germination, exposing the seeds to Compounds of formula (I) described in 1, 11 or 14, their agronomically acceptable salts, stereoisomers, diastereomers, mirror isomers, tautomers, polymorphs, metal Complexes, N-oxides, compositions or combinations thereof. A use of a compound of formula (I) as described in Claim 1, 11 or 14, its salt, metal complex, N-oxide, isomer, homogeneous polymorph, composition or combination thereof, which is For the control of insect and mite pests in crops, horticultural crops, household and vector control, and parasites in animals. Use of the compound of formula (I) as described in claim item 19, wherein the crops are cereals, corn, sorghum, pearl millet (bajra), rice, soybeans, oilseeds and other leguminous plants, fruits and fruit trees, grapes, nuts And nut trees, citrus and citrus trees, any horticultural plants, cucurbits, oleaginous plants, tobacco, coffee, tea, cocoa, beets, sugar cane, cotton, potatoes, tomatoes, onions, peppers, other vegetables and ornamentals. A seed comprising a compound of formula (I) as described in Claim 1, 11 or 14, a salt thereof, a metal complex, an N-oxide, an isomer, a polymorph, a composition or a combination thereof, wherein The amount of the compound of formula (I) in the seed is from about 0.0001% to about 1% by weight. A method for preparing a compound of formula (I) as described in claim 1, wherein the method comprises the following steps: according to the reaction scheme shown below, making the compound of formula (II) and the compound of formula (VI) in a suitable reagent And react under the presence of solvent, to obtain formula (Ia) compound: Wherein, X, R ¹ , R ² , R ³ , A, D, p and q are as defined in Claim 1. A compound of formula (A), Formula (A) wherein, Z is selected from the group consisting of: OH, NH ₂ , SH, X, CN and leaving group (leaving group); X represents halogen; R ¹ is selected from the group consisting of Groups: C ₁ -C ₆ -alkyl, C ₁ -C ₆ -haloalkyl, C ₃ -C ₆ -cycloalkyl and C ₃ -C ₆ -halocycloalkyl; Cy is selected from the group consisting of Group: phenyl and C ₅ -C ₆ -heterocyclyl, which is optionally substituted by one or more R ² groups; wherein, R ² is selected from the group consisting of: hydrogen, halogen , nitrile, C ₁ -C ₆ -alkyl, C ₂ -C ₆ -alkenyl, C ₂ -C ₆ -alkynyl, C ₁ -C ₆ -haloalkyl, C ₂ -C ₆ -haloalkenyl and C ₃ -C ₈ -cycloalkyl; R ³ is selected from the group consisting of hydrogen, halogen, nitrile, nitro, C ₁ -C ₄ -alkyl, C ₂ -C ₄ -alkenyl , C ₂ -C ₆ -alkynyl, C _{1 -C} 4 -haloalkyl, C ₂ -C ₄ -haloalkenyl, C ₂ -C ₆ -haloalkynyl, C ₃ -C ₄ -cycloalkyl, C ₃ -C ₅ -heterocyclyl, -OC ₃ -C ₄ -heterocyclyl, SCN, SF ₅ , NR′R′′, OR′, S(O) _n R′ and CR′=NR′′; p and q represent the integers 0, 1 or 2; provided that p and q cannot simultaneously represent the integer 0; or agriculturally acceptable salts, stereoisomers, diastereomers, enantiomers, tautomers thereof compounds, metal complexes, polymorphs or N-oxides.