TW202322866A - 使用交流電場治療患者時減少電感覺 - Google Patents
使用交流電場治療患者時減少電感覺 Download PDFInfo
- Publication number
- TW202322866A TW202322866A TW111137075A TW111137075A TW202322866A TW 202322866 A TW202322866 A TW 202322866A TW 111137075 A TW111137075 A TW 111137075A TW 111137075 A TW111137075 A TW 111137075A TW 202322866 A TW202322866 A TW 202322866A
- Authority
- TW
- Taiwan
- Prior art keywords
- electrode element
- electrical signal
- during
- patient
- electrode
- Prior art date
Links
- 230000005684 electric field Effects 0.000 title claims abstract description 113
- 230000035807 sensation Effects 0.000 claims abstract description 54
- 238000000034 method Methods 0.000 claims description 72
- 210000004126 nerve fiber Anatomy 0.000 claims description 39
- 230000036982 action potential Effects 0.000 claims description 15
- 230000006870 function Effects 0.000 claims description 8
- 230000008499 blood brain barrier function Effects 0.000 claims description 7
- 208000035824 paresthesia Diseases 0.000 claims description 7
- 230000003213 activating effect Effects 0.000 claims description 6
- 210000001218 blood-brain barrier Anatomy 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 5
- 230000035699 permeability Effects 0.000 claims description 5
- 206010028347 Muscle twitching Diseases 0.000 claims description 4
- 230000008602 contraction Effects 0.000 claims description 4
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims description 4
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- 208000014674 injury Diseases 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 230000000259 anti-tumor effect Effects 0.000 claims description 2
- 230000002459 sustained effect Effects 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 10
- 210000002569 neuron Anatomy 0.000 abstract description 6
- 238000013459 approach Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 2
- 230000008447 perception Effects 0.000 description 8
- 238000003491 array Methods 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 101800001718 Amyloid-beta protein Proteins 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000005017 glioblastoma Diseases 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/323—Interference currents, i.e. treatment by several currents summed in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163250675P | 2021-09-30 | 2021-09-30 | |
| US63/250,675 | 2021-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202322866A true TW202322866A (zh) | 2023-06-16 |
Family
ID=83692679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111137075A TW202322866A (zh) | 2021-09-30 | 2022-09-29 | 使用交流電場治療患者時減少電感覺 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230098801A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4408516A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2024533777A (cg-RX-API-DMAC7.html) |
| CN (1) | CN118043105A (cg-RX-API-DMAC7.html) |
| TW (1) | TW202322866A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2023053044A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240027008A (ko) * | 2021-06-30 | 2024-02-29 | 노보큐어 게엠베하 | 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용 |
| US12599765B2 (en) | 2021-12-14 | 2026-04-14 | Novocure Gmbh | Shifting of transducer array to reduce skin irritation |
| JP2024545019A (ja) | 2021-12-30 | 2024-12-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択 |
| CA3255022A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS |
| IL314392A (en) | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN121925295A (zh) * | 2023-09-29 | 2026-04-24 | 诺沃库勒有限责任公司 | 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000056395A1 (en) * | 1999-03-25 | 2000-09-28 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US7146210B2 (en) * | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7805201B2 (en) * | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US11752329B2 (en) * | 2018-07-01 | 2023-09-12 | Presidio Medical, Inc. | Systems and methods for nerve conduction block |
| JP6974671B2 (ja) * | 2018-08-23 | 2021-12-01 | ノボキュア ゲーエムベーハー | 血液脳関門の透過性を向上させるための交流電界の使用 |
| US11160977B2 (en) * | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| CN112930209B (zh) * | 2018-10-15 | 2024-10-15 | 诺沃库勒有限责任公司 | 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields)的装置和方法 |
-
2022
- 2022-09-29 TW TW111137075A patent/TW202322866A/zh unknown
- 2022-09-29 WO PCT/IB2022/059265 patent/WO2023053044A1/en not_active Ceased
- 2022-09-29 US US17/955,656 patent/US20230098801A1/en active Pending
- 2022-09-29 JP JP2024519394A patent/JP2024533777A/ja active Pending
- 2022-09-29 CN CN202280065962.8A patent/CN118043105A/zh active Pending
- 2022-09-29 EP EP22790040.4A patent/EP4408516A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230098801A1 (en) | 2023-03-30 |
| WO2023053044A1 (en) | 2023-04-06 |
| CN118043105A (zh) | 2024-05-14 |
| JP2024533777A (ja) | 2024-09-12 |
| EP4408516A1 (en) | 2024-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW202322866A (zh) | 使用交流電場治療患者時減少電感覺 | |
| CN110893261A (zh) | 具有降低能量的交错多触点神经调制治疗 | |
| EP2209518B1 (en) | Onset-mitigating high-frequency nerve block | |
| JP7710117B2 (ja) | トランスデューサアレイをペアリングすることによる交流電場を用いた被験者の治療および電気感覚の軽減 | |
| US9008791B2 (en) | Electrode system for transcutaneous nerve and/or muscle stimulation | |
| US20230414955A1 (en) | Closed-Loop Technique to Reduce Electrosensation While Treating a Subject Using Alternating Electric Fields | |
| EP3897818B1 (en) | Nerve stimulation system | |
| TW202333820A (zh) | 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺 | |
| TW202428320A (zh) | 透過增加波形的斜坡上升部分的步階數量減少使用交流電場治療受試者時的電感覺 | |
| TW202434331A (zh) | 透過確保在交流波形的相反相位期間發生振幅連續增加來減少施加交變電場期間的電感應 | |
| JP2026511465A (ja) | 電場の振幅を徐々に増加させることによる、回転交流電場を使用して被験者を治療するときの電気感覚の低減 | |
| JP2025533795A (ja) | 選択された電極素子を非アクティブ化することによる、交流電場を用いた被験者の治療に伴う電気感覚の軽減 | |
| JP2025533032A (ja) | ランプアップ特性を制御することによる交流電場を用いた被験者の治療における電気感覚の軽減 | |
| HK40117777A (en) | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together | |
| HK40117777B (en) | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together | |
| HK40118170A (en) | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together | |
| TW202528013A (zh) | 使用振幅和頻率的交錯變化來改善交變電場治療期間的電感覺 | |
| WO2024050557A2 (en) | Treatment of tissue using electrical stimulation pulses based on non-canceled electrical output | |
| HK40061274A (en) | Kilohertz e-tns stimulation |