TW202317062A - Oral tablet manufacturing apparatus and manufacturing method for manufacturing oral tablets with reduced tablet thickness by effectively controlling medicine powders and the number of colloid layers - Google Patents

Abstract

Disclosed are an oral tablet manufacturing apparatus and its manufacturing method. The apparatus includes a tablet manufacturing area, a micro control unit, and a material picking area. The tablet manufacturing area includes a tablet spraying device. The tablet spraying device has a roller and a piezoelectric nozzle. A medicine powder filling container is in communication with the piezoelectric nozzle. The medicine powder filling container contains a plurality of medicine powders, and the medicine powders are sprayed and printed through the piezoelectric nozzle. Then, the medicine powders are pressed and flattened by the rollers, so as to form a tablet from the medicine powders. The micro control unit is disposed in the piezoelectric nozzle. The micro control unit has a storage module and an execution control module. The storage module stores tablet spraying information. The execution control module controls the tablet spraying device through the tablet spraying information. The material picking area is used to collect the tablets.

Description

Oral tablet manufacturing equipment and manufacturing method thereof

The present invention relates to an oral tablet manufacturing equipment, especially to an oral tablet manufacturing equipment and its manufacturing method which can effectively control the number of layers of drug powder and colloid to reduce the thickness of the tablet.

By the way, the pills seen on the market are one of the most common types in medicine bags. The existing medicine pills are to put the mixed powder into the tablet press machine, slide down from the upper hopper, enter the powder chute and fall into a group In the ingot mould, the size of the space in the mold determines the volume and thickness of the tablet. After entering the mold, the powder will have a preliminary appearance according to the shape of the mold. The structure is loose, and the thickness is about the thickness of the final product. 2~3 times, and then the upper and lower molds squeeze each other, pressing the originally loose powder into a strong tablet that can withstand collisions, and finally the lower mold will push the tablet out of the mold. The appearance and size of the tablet can be determined by designing the shape of the mold, and through the manufacturing process of filling, extrusion, mold release and rotation of the machine, tens of thousands of the same tablet can be produced in a short period of time. This traditional medicine In the way of making ingots, it is not only necessary to mix the ingredients and proportions of the medicine first, and then make them in molds. Therefore, one kind of medicine ingot needs one kind of compression molding tool. Due to the loss of the compression molding tool, multiple sets must be prepared. The same compression molding tool also leads to high overall cost. When the production volume of special tablets is not high, the unit price of tablets cannot be reduced. Moreover, the volume formed by the thickness and area of conventional tablet production methods It is limited by the mold, and the volume of the tablet cannot be adjusted at any time according to the demand.

Therefore, how to solve the above-mentioned conventional problems and deficiencies is the direction that relevant manufacturers engaged in this industry want to study and improve.

Therefore, in order to effectively solve the above-mentioned problems, the main purpose of the present invention is to provide an oral tablet manufacturing equipment that can effectively control the number of layers of drug powder and colloid to reduce the thickness of the tablet.

The secondary purpose of this creation is to manufacture oral tablet manufacturing equipment that is fast and reduces mold development and manufacturing costs.

The secondary purpose of this creation is to provide a method for making oral tablets that can effectively control the number of powder and colloid layers to reduce the thickness of the tablet.

The secondary purpose of this creation is to manufacture an oral tablet manufacturing method that is fast and reduces mold development and manufacturing costs.

In order to achieve the above purpose, the present invention provides a kind of oral tablet manufacturing equipment, which includes a tablet manufacturing area, a micro-control unit and a material picking area, the tablet manufacturing area includes a tablet spraying device, the tablet spraying The device has a roller and a piezoelectric nozzle, a powder filling container is connected to the piezoelectric nozzle, the powder filling container contains a plurality of powders, and the powders are sprayed through the piezoelectric nozzle, and then passed through the roller Carry out powder pressing and flattening operations on the medicinal powder, so that the medicinal powder forms a tablet. The micro-control unit is arranged in the piezoelectric nozzle. The micro-control unit has a storage module and an execution control module. The storage module A tablet spraying message is stored, the execution control module controls the tablet spraying device through the tablet spraying message, and the picking area is used to collect the tablet.

In one embodiment, the tablet manufacturing area and material picking area are located in a sealed cavity.

In one embodiment, there is further a glue filling container connected to the piezoelectric nozzle, the glue filling container contains a glue and the printing operation is performed through the piezoelectric nozzle.

In one embodiment, there is further a transition area adjacent to the picking area, and the tablet is delivered to the transition area after being opened by a one-way valve body from the picking area.

In one embodiment, the tablet spraying information includes drug powder composition, drug powder layer number, colloid composition, colloid layer number and tablet area.

In order to achieve the above-mentioned purpose, the present invention provides a kind of oral tablet manufacturing method, adopts the oral tablet manufacturing equipment as aforementioned embodiment, it is characterized in that comprising the following steps: S1: Provide a tablet spraying device with a roller and a piezoelectric nozzle; S2: filling a plurality of powders and a colloid into a powder filling container and a colloid filling container respectively, and connecting the powder filling container and the colloid filling container to the piezoelectric nozzle; S3: Provide a micro-control unit with a storage module and an execution control module, the execution control module controls the tablet spraying device through a tablet spraying message in the storage module, so that the powder and colloid Use the piezoelectric nozzle to perform printing operations, and then use the roller to perform powder pressing and flattening operations on the powders and colloids; S4: Repeatedly spraying, pressing and flattening the medicinal powder and colloid to form a tablet.

In one embodiment, the medicinal powder contains at least chloral hydrate, benzodiazepines, zopiclone, zolpidem and excipients.

In one embodiment, the medicated powder at least contains phenytoin, carbamazepine, lamotrigine, valproic acid, clonazepam, oxcarbazepine, Lumina, Topamate, Zhenmanian, Xiepiyi and excipients.

In one embodiment, the medicinal powder contains at least sildenafil, tadalafil, microcrystalline cellulose, croscarmellose sodium, nitroglycerin and excipients.

In one embodiment, the excipients can be microcrystalline cellulose, calcium phosphate polyvinylpyrrolidone, Guanhua bean gum, sodium fumarate stearate, xylitol, sodium gluconate, magnesium metaaluminate, One or a combination of maltose, mannitol, microcrystalline cellulose, polyvinyl acetate, and sorbitol.

With the design of this system of the present invention, through the structural design of the piezoelectric nozzle of the tablet spraying device, the number of control powder and colloid layers can be effectively reduced to reduce the thickness of the tablet, and at the same time, it can achieve faster manufacturing and reduce the production cost of mold development .

The above-mentioned purpose of the present invention and its structural and functional characteristics will be described based on the preferred embodiments of the accompanying drawings.

In the following, for the composition and technical content of the oral tablet manufacturing equipment and its manufacturing method of the present invention, etc., enumerate various applicable examples and describe in detail with reference to the accompanying drawings; however, the present invention is certainly not limited The examples, drawings, or detailed descriptions listed here are just for reference.

Furthermore, those who are familiar with this technology should also understand that the listed embodiments and accompanying drawings are only for reference and description, and are not used to limit the present invention; they can be easily implemented based on these records. Inventions completed through modification or alteration are also considered within the scope of not departing from the spirit and intent of the present invention, and of course such inventions are also included in the scope of the patent application of the present invention.

In addition, the directional terms mentioned in the following embodiments, such as "upper", "lower", "left", "right", "front", "rear", etc., are only referring to the directions attached to the drawings. Therefore, the used directional terms are used to illustrate rather than limit the present invention; moreover, in the following embodiments, the same or similar components will use the same or similar component numbers.

Please refer to Figures 1, 2, 3A, 3B, and 3C, which are the three-dimensional schematic diagram and block diagram of the first embodiment of the oral tablet manufacturing equipment of the present invention and the block diagram and schematic diagram of the piezoelectric nozzle. As shown in the figure, a Oral tablet manufacturing equipment 1 comprises a tablet manufacturing area 10, a micro-control unit 11 and a material picking area 12, the tablet manufacturing area 10 includes a tablet spraying device 100, and the tablet spraying device 100 has a Roller 101 and a piezoelectric nozzle 102, a powder filling container 103 connected to the piezoelectric nozzle 102, the powder filling container 103 holds a plurality of powders, and the powders are sprayed through the piezoelectric nozzle 102, and then The powders are compressed and flattened through the roller 101, so that the powders are formed into a tablet. In addition, the tablet spraying device 100 further has a colloid filling container 104, which is also connected to the colloid filling container 104. The piezoelectric nozzle 102, the colloid filling container 104 holds a colloid and performs printing operations through the piezoelectric nozzle 102. In other words, the piezoelectric nozzle 102 sprays powder repeatedly and alternately during operation. and colloid, so that the drug powder and colloid after lamination form the tablet.

The micro-control unit 11 is arranged in the piezoelectric spray head 102, the micro-control unit 11 has a storage module 110 and an execution control module 111, the storage module 110 is used to store a tablet spraying message, the The execution control module 111 controls the tablet spraying device 100 through the tablet spraying information. Ingot area, etc.

The aforementioned ingot manufacturing area 12 is adjacent to the ingot manufacturing area 10, the ingot manufacturing area 12 is used to collect the ingots, the ingot manufacturing area 10 and the ingot manufacturing area 12 are in a sealed cavity, and Prevent the tablet manufacturing area 10 and the picking area 12 from external pollution.

It should be noted that the oral medicine tablet manufacturing equipment 1 firstly fills the medicine powder in the medicine powder filling container 103 during the manufacture of the medicine medicine tablet, wherein if the medicine medicine tablet is a hypnotic medicine, the medicine powder composition at least contains chloral hydrate , benzodiazepines, zopiclone, zolpidem and excipients, if the tablets are antiepileptic drugs, the powder ingredients contain at least phenytoin, carbamazepine, lamotrigine, valproic acid , clonazepam, oxcarbazepine, Lemingda, Tuotai, Zhenwandian, Xidianyi and excipients, if the tablet is a cardiovascular drug, its powder ingredients contain at least sildenafil, Tadalafil, microcrystalline cellulose, croscarmellose sodium, nitroglycerin and excipients, wherein the excipients can be microcrystalline cellulose, calcium phosphate polyvinylpyrrolidone, Guanhua bean gum, Corydalis corydalis One of sodium stearate, xylitol, sodium gluconate, magnesium metaaluminate, maltose, mannitol, microcrystalline cellulose, polyvinyl acetate, sorbitol or a combination thereof, in addition, the colloid is filled in the colloid The container 104 is filled.

In addition, it should be noted that the oral medicine manufacturing equipment of the present invention further has a fan filter module 15, which is used to form a negative pressure inside the tablet manufacturing area 10, the material reducing area and the transition area 13, and can Blow off and clean the dust inside. In addition, the present invention also has a central control unit 16, which is used to control the overall operation of the oral medicine custom manufacturing equipment 1.

Therefore, when the medicine powder filling container 103 is filled with medicine powder and the colloid filling container 104 is filled with colloid, the tablet spraying device 100 can be controlled by the micro-control unit 11 to spray the medicine powder, and the execution control module The group 111 controls the tablet spraying device 100 through the tablet spraying information. Therefore, the execution control module 111 not only controls the spraying amount of the powder, but also controls the spraying amount of the colloid at the same time, and makes the powder and the colloid Repeated and alternate spraying, so that the layered drug powder and colloid form the tablet, and then complete the tablet with a specified number of layers and thickness on the tablet manufacturing area 10, thereby achieving effective control of the drug powder and colloid layer In order to reduce the thickness of the tablet, it can also achieve faster manufacturing and reduce the production cost of mold development.

Please refer to Fig. 4, which is a block diagram of the second embodiment of the oral tablet manufacturing equipment of the present invention, and the corresponding relationship between the components of the oral tablet manufacturing equipment and the aforementioned oral tablet manufacturing equipment is the same as that of the aforementioned oral tablet manufacturing equipment, Therefore, it will not be repeated here, but the main difference between this oral tablet manufacturing equipment and the aforementioned is that the oral tablet manufacturing equipment 1 further has a transition area 13, which is adjacent to the picking area 12, and A one-way valve body 14 is arranged between the transition zone 13 and the material reduction zone, and the tablet is conveyed to the transition zone 13 after being opened by the pick-up zone 12 through the one-way valve body 14 to complete the tablet collection work.

Please refer to Fig. 5, which is a flow chart of the steps of the oral tablet manufacturing method of the present invention. As shown in the figure, a kind of oral tablet manufacturing method includes:

S1: Provide a tablet spraying device 100 with a roller and a piezoelectric spray head; Firstly, a tablet spraying device 100 is provided, and a roller 101 and a piezoelectric spray head 102 are arranged in the tablet spraying device 100 .

S2: filling a plurality of powders and a colloid into a powder filling container and a colloid filling container respectively, and connecting the powder filling container and the colloid filling container to the piezoelectric nozzle; A powder filling container 103 and a colloid filling container 104 are provided, and the powder filling container 103 and the colloid filling container 104 are connected to the piezoelectric nozzle 102 of the tablet spraying device 100, and the powder filling container 103 holds a plurality of powders, The gel filling container 104 holds a gel.

S3: Provide a micro-control unit with a storage module and an execution control module, the execution control module controls the tablet spraying device through a tablet spraying message in the storage module, so that the powder and colloid Use the piezoelectric nozzle to perform printing operations, and then use the roller to perform powder pressing and flattening operations on the powders and colloids; The piezoelectric spray head 102 is provided with a micro-control unit 11. The micro-control unit 11 has a storage module 110 and an execution control module 111. The micro-control unit 11 controls the powder spraying device to spray the powder. The execution control module 111 controls the tablet spraying device 100 through a tablet spraying message. Therefore, the execution control module 111 not only controls the spraying amount of the powder, but also controls the spraying amount of the colloid at the same time, so that the The medicinal powder and colloid are sprayed and printed through the piezoelectric nozzle 102 , and then the aforementioned roller 101 is used to press and flatten the medicinal powder and colloid.

S4: Repeatedly spraying, pressing and flattening the medicinal powder and colloid to form a tablet. The drug powder and colloid are sprayed repeatedly and alternately, so that the layered drug powder and colloid form the tablet, and then the drug tablet with the specified number of layers and thickness is completed on the tablet manufacturing area 10 . In this way, through the oral tablet manufacturing method of the present invention, the number of layers of drug powder and colloid can be effectively controlled to reduce the thickness of the tablet, and at the same time, it can achieve faster manufacturing and reduce the manufacturing cost of mold development.

In summary, the present invention has the following advantages compared to the prior art: 1. It can effectively control the number of powder and colloid layers to reduce the thickness of the tablet; 2. Fast manufacturing and reduced mold development and manufacturing costs.

1: Oral tablet manufacturing equipment 10: Tablet manufacturing area 100: Tablet spraying device 101:Roller 102: Piezoelectric nozzle 103: Powder filling container 104: Colloid filled container 11: Micro control unit 110: storage module 111:Executing the control module 12: Picking area 13: Transition zone 14: One-way valve body 15: Fan filter module 16: Central control unit S1～S4: steps

Figure 1 is a three-dimensional schematic view of the first embodiment of the oral tablet manufacturing equipment of the present invention; Fig. 2 is another perspective schematic diagram of the first embodiment of the oral tablet manufacturing equipment of the present invention; Fig. 3A is a block diagram of the first embodiment of the oral tablet manufacturing equipment of the present invention; Figure 3B is a block diagram of the piezoelectric nozzle of the present invention; Figure 3C is a schematic diagram of the piezoelectric nozzle of the present invention; Fig. 4 is a block diagram of the second embodiment of the oral tablet manufacturing equipment of the present invention; Fig. 5 is a flow chart of the steps of the oral tablet manufacturing method of the present invention.

1: Oral tablet manufacturing equipment

10: Tablet manufacturing area

100: Tablet spraying device

101:Roller

102: Piezoelectric nozzle

103: Powder filling container

104: Colloid filled container

11: Micro control unit

12: Picking area

Claims (10)

A kind of oral tablet manufacturing equipment comprises: A tablet manufacturing area, which includes a tablet spraying device, the tablet spraying device has a roller and a piezoelectric nozzle, a powder filling container is connected to the piezoelectric nozzle, the powder filling container holds a plurality of powders, and The powders are sprayed and printed through the piezoelectric nozzle, and the powders are pressed and flattened by the roller, so that the powders are formed into a tablet; A micro-control unit, which is installed in the piezoelectric nozzle, the micro-control unit has a storage module and an execution control module, the storage module is used to store a tablet spraying information, the execution control module controlling the tablet spraying device through the tablet spraying information; and A material picking area is adjacent to the ingot manufacturing area, and the material picking area is used to collect the ingots. The oral tablet manufacturing equipment according to claim 1, wherein the tablet manufacturing area and the picking area are located in a sealed cavity. The oral tablet manufacturing equipment as described in Claim 1 further has a colloid filling container connected to the piezoelectric nozzle, and the colloid filling container contains a colloid and performs printing operations through the piezoelectric nozzle. The oral tablet manufacturing equipment as described in claim 1 further has a transition area adjacent to the picking area, and the tablet is conveyed to the transition area after being opened by a one-way valve body from the picking area . The tablet manufacturing equipment for oral administration as described in claim 1, wherein the tablet spraying information includes drug powder composition, drug powder layer number, colloid composition, colloid layer number and tablet area. A method for manufacturing oral tablets, using the oral tablet manufacturing equipment as described in any one of claims 1 to 4, characterized in that it includes the following steps: S1: Provide a tablet spraying device with a roller and a piezoelectric nozzle; S2: filling a plurality of powders and a colloid into a powder filling container and a colloid filling container respectively, and connecting the powder filling container and the colloid filling container to the piezoelectric nozzle; S3: Provide a micro-control unit with a storage module and an execution control module, the execution control module controls the tablet spraying device through a tablet spraying message in the storage module, so that the powder and colloid Use the piezoelectric nozzle to perform printing operations, and then use the roller to perform powder pressing and flattening operations on the powders and colloids; S4: Repeatedly spraying, pressing and flattening the medicinal powder and colloid to form a tablet. The manufacturing method of oral tablets as described in Claim 6, wherein the powder contains at least chloral hydrate, benzodiazepines, zopiclone, zolpidem and excipients. The method for manufacturing oral tablets as described in claim 6, wherein the powder contains at least phenytoin, carbamazepine, lamotrigine, valproic acid, clonazepam, oxcarbazepine, Lemingda, and Topate , Town stubborn Dian, She epilepsy easy and excipients. The manufacturing method of oral tablets as claimed in item 6, wherein the powder contains at least sildenafil, tadalafil, microcrystalline cellulose, croscarmellose sodium, nitroglycerin and excipients. The oral tablet manufacturing method as described in claim items 7 to 9, wherein the excipients can be microcrystalline cellulose, calcium phosphate polyvinylpyrrolidone, Guanhua bean gum, sodium fumarate stearate, xylitol, One or a combination of sodium gluconate, magnesium metaaluminate, maltose, mannitol, microcrystalline cellulose, polyvinyl acetate, sorbitol.

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