CN114053150A - Oral tablet manufacturing equipment and manufacturing method thereof - Google Patents
Oral tablet manufacturing equipment and manufacturing method thereof Download PDFInfo
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- CN114053150A CN114053150A CN202111292658.0A CN202111292658A CN114053150A CN 114053150 A CN114053150 A CN 114053150A CN 202111292658 A CN202111292658 A CN 202111292658A CN 114053150 A CN114053150 A CN 114053150A
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- medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
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- Veterinary Medicine (AREA)
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Abstract
An oral medicine spindle manufacturing device and a manufacturing method thereof comprise a medicine spindle manufacturing area, a micro control unit and a material picking area, wherein the medicine spindle manufacturing area comprises a medicine spindle spraying device, the medicine spindle spraying device is provided with a roller and a piezoelectric type spray head, a medicine powder filling container is communicated with the piezoelectric type spray head and contains a plurality of medicine powder, the medicine powder is subjected to spraying and printing operation through the piezoelectric type spray head, the medicine powder is pressed and flattened through the roller to form a medicine spindle, the micro control unit is arranged in the piezoelectric type spray head and is provided with a piezoelectric type storage module and an execution control module, the storage module stores medicine spindle spraying information, the execution control module controls the medicine spindle spraying device through medicine spindle spraying, and the material picking area is used for collecting the medicine spindles.
Description
Technical Field
The invention relates to an oral tablet manufacturing device, in particular to an oral tablet manufacturing device and a manufacturing method thereof, which can effectively control the layer number of medicine powder and colloid so as to reduce the thickness of a tablet.
Background
At present, the medicine spindle seen in the market is one of the most common types in the medicine bag, the traditional medicine spindle is manufactured by the steps that mixed medicine powder enters a tablet pressing machine to slide down from a hopper above, enters a powder groove and falls into a group of tablet beating dies, the volume and the thickness of the tablet are determined by the size of a space in the die, the powder entering the die has a preliminary appearance according to the shape of the die, the structure is loose, the thickness is about 2-3 times of that of a final product, then the upper die and the lower die extrude each other, the original loose medicine powder is pressed into a firm tablet which can resist collision, and finally the lower die pushes the medicine spindle upwards out of the die. The appearance and size of the tablet can be determined by the shape of the designed mould, and tens of thousands of identical tablets can be manufactured in a short time through the manufacturing process of filling, extruding and demoulding rotation of a machine.
Therefore, there is a need in the art for a new solution to the above-mentioned problems.
Disclosure of Invention
The invention mainly aims to provide an oral tablet manufacturing device which can effectively control the layer number of medicinal powder and colloid so as to reduce the thickness of the tablet;
a secondary object of the present invention is to produce an oral tablet manufacturing apparatus that is fast and reduces the cost of die development;
the secondary purpose of the invention is to provide a manufacturing method of an oral tablet, which can effectively control the layer number of the medicine powder and the colloid so as to reduce the thickness of the tablet;
a secondary object of the present invention is to provide a method of manufacturing oral tablets that is fast and reduces the cost of development and manufacture of the molds.
In order to achieve the purpose, the technical scheme of the invention is as follows:
an oral tablet manufacturing apparatus comprising
A tablet manufacturing area, which comprises a tablet spraying device, wherein the tablet spraying device is provided with a roller and a piezoelectric type spray head, a medicine powder filling container is communicated with the piezoelectric type spray head, the medicine powder filling container contains a plurality of medicine powder, the medicine powder is subjected to spray printing operation through the piezoelectric type spray head, and the medicine powder is subjected to powder pressing and flattening operation through the roller so as to form a tablet by the medicine powder;
the micro control unit is arranged in the piezoelectric type spray head and is provided with a storage module and an execution control module, the storage module is used for storing a medicine ingot spraying message, and the execution control module controls the medicine ingot spraying device through the medicine ingot spraying message;
and a material picking area adjacent to the tablet manufacturing area for collecting the tablets.
Further, the tablet manufacturing area and the material picking area are positioned in a sealed cavity.
Furthermore, a colloid filling container is communicated with the piezoelectric type spray head, and the colloid filling container contains a colloid and carries out spray printing operation through the piezoelectric type spray head.
Furthermore, a transition area is adjacent to the material picking area, and the medicine ingots are conveyed to the transition area after being opened by a one-way valve body from the material picking area.
Further, the tablet spraying information comprises the components of the powder, the number of layers of the powder, the colloid component, the number of layers of the colloid and the area of the tablet.
A method for manufacturing an oral tablet comprises the following steps:
s1: providing a tablet spraying device with a roller and a piezoelectric type spray head;
s2: filling a plurality of medicinal powders and a colloid into a medicinal powder filling container and a colloid filling container respectively, and communicating the medicinal powder filling container and the colloid filling container with the piezoelectric type spray head;
s3: providing a micro control unit with a storage module and an execution control module, wherein the execution control module controls the medicine spindle spraying device through a medicine spindle spraying message in the storage module so as to enable the medicine powder and the colloid to carry out spraying and printing operation through the piezoelectric type spray head, and then, the roller carries out powder pressing and leveling operation on the medicine powder and the colloid;
s4: repeatedly and continuously spraying, pressing and flattening the medicinal powder and the colloid to form a medicinal tablet.
Further, the medicinal powder at least comprises chloral hydrate and benzodiazepine
Quasi-drugs, zopiclone, azoles and azetidine and excipient.
Further, the medicinal powder at least comprises phenytoin, carbamazepine, lamotrigine, valproic acid, clonazepam, oxcarbazepine, lenoda, tolatae, medicinal atropa, pardon cartap and excipient.
Further, the medicinal powder at least comprises sildenafil, tadalafil, microcrystalline cellulose, croscarmellose sodium, nitroglycerin and an excipient.
Further, the excipient may be one of microcrystalline cellulose, calcium phosphate polyvinylpyrrolidone, guar gum, sodium stearate, xylitol, sodium gluconate, magnesium metaaluminate, maltose, mannitol, microcrystalline cellulose, polyvinyl acetate, sorbitol, or a combination thereof.
The invention adopting the technical scheme can bring the following beneficial effects:
1. the layer number of the medicinal powder and the colloid can be effectively controlled to reduce the thickness of the medicinal tablet;
2. the manufacturing is fast and the cost of developing and manufacturing the die is reduced.
Drawings
FIG. 1 is a schematic perspective view of a first embodiment of an apparatus for manufacturing an oral tablet according to the present invention;
FIG. 2 is a schematic perspective view of another embodiment of an apparatus for manufacturing an oral tablet according to the present invention;
FIG. 3A is a block diagram of an apparatus for manufacturing oral tablets according to a first embodiment of the present invention;
FIG. 3B is a block diagram of a piezoelectric showerhead according to the present invention;
FIG. 3C is a schematic view of a piezoelectric showerhead according to the present invention;
FIG. 4 is a block diagram of an apparatus for manufacturing oral tablets according to a second embodiment of the present invention;
FIG. 5 is a flow chart of the steps of the method of making an oral tablet of the present invention.
In the figure, 1-oral tablet manufacturing equipment, 10-tablet manufacturing area, 100-tablet spraying device, 101-roller, 102-piezoelectric type spray head, 103-powder filling container, 104-colloid filling container, 11-micro control unit, 110-storage module, 111-execution control module, 12-material picking area, 13-transition area, 14-one-way valve body, 15-fan filtering module, 16-central control unit and S1-S4-steps.
Detailed Description
Referring to fig. 1, fig. 2, fig. 3A, fig. 3B, and fig. 3C, which are a schematic perspective view and a block diagram of a first embodiment of an oral tablet manufacturing apparatus according to the present invention and a schematic block diagram of a piezoelectric nozzle, as shown in the figure, an oral tablet manufacturing apparatus 1 includes a tablet manufacturing area 10, a micro control unit 11, and a material picking area 12, the tablet manufacturing area 10 includes a tablet spraying apparatus 100, the tablet spraying apparatus 100 includes a roller 101 and a piezoelectric nozzle 102, a powder filling container 103 is connected to the piezoelectric nozzle 102, the powder filling container 103 contains a plurality of powder, the powder is sprayed and printed by the piezoelectric nozzle 102, the powder is pressed and leveled by the roller 101 to form a tablet from the powder, and the tablet spraying apparatus 100 further includes a colloid filling container 104, the colloid filling container 104 is also connected to the piezoelectric nozzle 102, and the colloid filling container 104 contains a colloid and performs a spray printing operation through the piezoelectric nozzle 102, in other words, the piezoelectric nozzle 102 repeatedly and alternately sprays the powder and the colloid during the operation, so that the stacked powder and colloid form the tablet.
The micro control unit 11 is disposed in the piezoelectric nozzle 102, the micro control unit 11 has a storage module 110 and an execution control module 111, the storage module 110 is used to store a tablet spraying message, and the execution control module 111 controls the tablet spraying device 100 through the tablet spraying message, wherein the tablet spraying message includes powder components, the number of layers of powder, colloid components, the number of layers, the area of the tablet, and the like.
The aforementioned material picking area 12 is adjacent to the tablet manufacturing area 10, the material picking area 12 is used for collecting the tablets, and the tablet manufacturing area 10 and the material picking area 12 are located in a sealed cavity, so as to prevent the tablet manufacturing area 10 and the material picking area 12 from being contaminated from the outside.
Specifically, the manufacturing apparatus 1 for manufacturing an oral tablet fills the powder into the powder filling container 103 when manufacturing the tablet, wherein the tablet is for sleeping, and the powder component at least comprises chloral hydrate and benzodiazepine
The compound medicine, zopiclone, azolidine and excipient, if the tablet is for anti-epileptic, the powder components at least include phenytoin, carbamazepine, lamotrigine, valproic acid, clonazepam, oxcarbazepine, latadine, tutin, atrophide, pardon, and excipient, if the tablet is for cardiovascular medicine, the powder components at least include sildenafil, tadalafil, microcrystalline cellulose, croscarmellose sodium, nitroglycerin, and excipient, wherein the excipient may be one or a combination of microcrystalline cellulose, calcium phosphate polyvinylpyrrolidone, guava gum, sodium stearate, xylitol, sodium gluconate, magnesium metaaluminate, maltose, mannitol, microcrystalline cellulose, polyvinyl acetate, and sorbitol, and the colloid is filled in a colloid filling container 104.
In addition, it should be noted that the oral dosing and manufacturing equipment of the present invention further comprises a fan filter module 15 for forming a negative pressure inside the tablet manufacturing area 10, the material reduction area and the transition area 13, and blowing off and cleaning the dust inside the tablet manufacturing area. In addition, the present invention further has a central control unit 16 for controlling the overall operation of the oral dosing and manufacturing apparatus 1.
Therefore, when the powder filling container 103 is filled with powder and the colloid filling container 104 is filled with colloid, the micro control unit 11 controls the tablet spraying device 100 to spray powder, and the execution control module 111 controls the tablet spraying device 100 through the tablet spraying message, so that the execution control module 111 not only controls the spraying amount of the powder, but also controls the spraying amount of the colloid, and makes the powder and the colloid repeatedly and alternately spray, so that the stacked powder and colloid form the tablet, and further completes the tablets with specified number of layers and thickness on the tablet manufacturing area 10, thereby effectively controlling the number of layers of the powder and colloid to reduce the thickness of the tablets, and further achieving the purpose of manufacturing more quickly and reducing the manufacturing cost of mold development.
Please refer to fig. 4, which is a block diagram of a second embodiment of an apparatus for manufacturing oral drug tablets according to the present invention, wherein the corresponding relationship between some components of the apparatus for manufacturing oral drug tablets is the same as the apparatus for manufacturing oral drug tablets, so that the detailed description is omitted herein, except that the apparatus for manufacturing oral drug tablets has a transition region 13, the transition region 13 is adjacent to the material picking region 12, a one-way valve 14 is disposed between the transition region 13 and the material reducing region, and the drug tablets are transported from the material picking region 12 to the transition region 13 after being opened by the one-way valve 14 to complete the operation of picking up the drug tablets.
Referring to fig. 5, which is a flow chart illustrating steps of a method for manufacturing an oral tablet according to the present invention, a method for manufacturing an oral tablet includes:
s1: providing a tablet spraying device 100 with a roller and a piezoelectric type nozzle;
firstly, a tablet spraying device 100 is provided, and a roller 101 and a piezoelectric nozzle 102 are disposed in the tablet spraying device 100.
S2: filling a plurality of medicinal powders and a colloid into a medicinal powder filling container and a colloid filling container respectively, and communicating the medicinal powder filling container and the colloid filling container with the piezoelectric type spray head;
a powder filling container 103 and a colloid filling container 104 are provided, the powder filling container 103 and the colloid filling container 104 are communicated with the piezoelectric nozzle 102 of the tablet spraying device 100, the powder filling container 103 contains a plurality of powder, and the colloid filling container 104 contains a colloid.
S3: providing a micro control unit with a storage module and an execution control module, wherein the execution control module controls the medicine spindle spraying device through a medicine spindle spraying message in the storage module so as to enable the medicine powder and the colloid to carry out spraying and printing operation through the piezoelectric type spray head, and then, the roller carries out powder pressing and leveling operation on the medicine powder and the colloid;
the piezoelectric type spray nozzle 102 is internally provided with a micro control unit 11, the micro control unit 11 is provided with a storage module 110 and an execution control module 111, the micro control unit 11 controls the powder spraying device to spray powder, and the execution control module 111 controls the powder spraying device 100 through a powder spray message, so that the execution control module 111 not only controls the spraying amount of the powder, but also controls the spraying amount of the colloid, the powder and the colloid are subjected to spray printing operation through the piezoelectric type spray nozzle 102, and the powder and the colloid are subjected to powder pressing and leveling operation through the roller 101.
S4: repeatedly and continuously spraying, pressing and flattening the medicinal powder and the colloid to form a medicinal tablet. The powder and the colloid are alternately sprayed repeatedly to form the stacked powder and colloid into the tablet, and the tablet with the specified number of layers and thickness is manufactured in the tablet manufacturing area 10.
Therefore, the method for manufacturing the oral tablet can effectively control the layer number of the medicinal powder and the colloid so as to reduce the thickness of the tablet, and can also achieve the purposes of faster manufacturing and reduction of the manufacturing cost of die development.
Claims (10)
1. An oral medicine tablet manufacturing device is characterized by comprising
A tablet manufacturing area, which comprises a tablet spraying device, wherein the tablet spraying device is provided with a roller and a piezoelectric type spray head, a medicine powder filling container is communicated with the piezoelectric type spray head, the medicine powder filling container contains a plurality of medicine powder, the medicine powder is subjected to spray printing operation through the piezoelectric type spray head, and the medicine powder is subjected to powder pressing and flattening operation through the roller so as to form a tablet by the medicine powder;
the micro control unit is arranged in the piezoelectric type spray head and is provided with a storage module and an execution control module, the storage module is used for storing a medicine ingot spraying message, and the execution control module controls the medicine ingot spraying device through the medicine ingot spraying message;
and a material picking area adjacent to the tablet manufacturing area for collecting the tablets.
2. An apparatus for manufacturing an oral tablet according to claim 1, wherein: the tablet manufacturing area and the material picking area are positioned in a sealed cavity.
3. An apparatus for manufacturing an oral tablet according to claim 1, wherein: and a colloid filling container is communicated with the piezoelectric type spray head, and the colloid filling container holds a colloid and carries out spray printing operation through the piezoelectric type spray head.
4. An apparatus for manufacturing an oral tablet according to claim 1, wherein: and a transition area is adjacent to the material picking area, and the medicine ingot is conveyed to the transition area after being opened by a one-way valve body from the material picking area.
5. An apparatus for manufacturing an oral tablet according to claim 1, wherein: the tablet spraying information comprises the components of the medicinal powder, the number of layers of the medicinal powder, the components of the colloid, the number of layers of the colloid and the area of the tablet.
6. An oral tablet manufacturing method using the oral tablet manufacturing apparatus according to any one of claims 1 to 4, characterized by comprising the steps of:
s1: providing a tablet spraying device with a roller and a piezoelectric type spray head;
s2: filling a plurality of medicinal powders and a colloid into a medicinal powder filling container and a colloid filling container respectively, and communicating the medicinal powder filling container and the colloid filling container with the piezoelectric type spray head;
s3: providing a micro control unit with a storage module and an execution control module, wherein the execution control module controls the medicine spindle spraying device through a medicine spindle spraying message in the storage module so as to enable the medicine powder and the colloid to carry out spraying and printing operation through the piezoelectric type spray head, and then, the roller carries out powder pressing and leveling operation on the medicine powder and the colloid;
s4: repeatedly and continuously spraying, pressing and flattening the medicinal powder and the colloid to form a medicinal tablet.
7. The method of manufacturing an oral tablet according to claim 6, wherein: the medicinal powder at least contains chloral hydrate and benzodiazepine
Quasi-drugs, zopiclone, azoles and azetidine and excipient.
8. The method of manufacturing an oral tablet according to claim 6, wherein: the medicinal powder at least comprises phenytoin, carbamazepine, lamotrigine, valproic acid, clonazepam, oxcarbazepine, lengda, tutin, medicinal material of intractable subvolume, pardon and excipient.
9. The method of manufacturing an oral tablet according to claim 6, wherein: the medicinal powder at least comprises sildenafil, tadalafil, microcrystalline cellulose, croscarmellose sodium, nitroglycerin and excipient.
10. A method of manufacturing an oral tablet according to any one of claims 7 to 9, characterized in that: the excipient can be one of microcrystalline cellulose, calcium phosphate polyvinylpyrrolidone, GUANHUADOU, rhizoma corydalis sodium stearate, xylitol, sodium gluconate, magnesium metaaluminate, maltose, mannitol, microcrystalline cellulose, polyvinyl acetate, and sorbitol, or their combination.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111292658.0A CN114053150A (en) | 2021-11-03 | 2021-11-03 | Oral tablet manufacturing equipment and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111292658.0A CN114053150A (en) | 2021-11-03 | 2021-11-03 | Oral tablet manufacturing equipment and manufacturing method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN114053150A true CN114053150A (en) | 2022-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111292658.0A Pending CN114053150A (en) | 2021-11-03 | 2021-11-03 | Oral tablet manufacturing equipment and manufacturing method thereof |
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| Country | Link |
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| CN (1) | CN114053150A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2032691B1 (en) * | 2022-08-05 | 2024-02-09 | Taiwan Mercury Medical Corp | Compound gel manufacturing equipment |
-
2021
- 2021-11-03 CN CN202111292658.0A patent/CN114053150A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2032691B1 (en) * | 2022-08-05 | 2024-02-09 | Taiwan Mercury Medical Corp | Compound gel manufacturing equipment |
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