TW202302579A - 用作sting 激動劑的新型化合物及其用途 - Google Patents
用作sting 激動劑的新型化合物及其用途 Download PDFInfo
- Publication number
- TW202302579A TW202302579A TW111112050A TW111112050A TW202302579A TW 202302579 A TW202302579 A TW 202302579A TW 111112050 A TW111112050 A TW 111112050A TW 111112050 A TW111112050 A TW 111112050A TW 202302579 A TW202302579 A TW 202302579A
- Authority
- TW
- Taiwan
- Prior art keywords
- oxy
- methyl
- propoxy
- thiophen
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/CN2021/083783 | 2021-03-30 | ||
| CN2021083783 | 2021-03-30 | ||
| CN2021090945 | 2021-04-29 | ||
| WOPCT/CN2021/090945 | 2021-04-29 | ||
| WOPCT/CN2021/128942 | 2021-05-11 | ||
| WOPCT/CN2021/111479 | 2021-08-09 | ||
| CN2021111479 | 2021-08-09 | ||
| CN2021128942 | 2021-11-05 | ||
| WOPCT/CN2021/130097 | 2021-11-11 | ||
| CN2021130097 | 2021-11-11 | ||
| WOPCT/CN2021/138806 | 2021-12-16 | ||
| CN2021138806 | 2021-12-16 | ||
| CN2021143043 | 2021-12-30 | ||
| WOPCT/CN2021/143043 | 2021-12-30 | ||
| WOPCT/CN2022/071548 | 2022-01-12 | ||
| CN2022071548 | 2022-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202302579A true TW202302579A (zh) | 2023-01-16 |
Family
ID=83457956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW111112050A TW202302579A (zh) | 2021-03-30 | 2022-03-29 | 用作sting 激動劑的新型化合物及其用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240116909A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP4313962B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2024511832A (cg-RX-API-DMAC10.html) |
| CN (1) | CN117203194A (cg-RX-API-DMAC10.html) |
| AR (1) | AR125608A1 (cg-RX-API-DMAC10.html) |
| TW (1) | TW202302579A (cg-RX-API-DMAC10.html) |
| UY (1) | UY39705A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2022206725A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250108123A1 (en) * | 2021-12-17 | 2025-04-03 | Jacobio Pharmaceuticals Co., Ltd. | Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof |
| WO2024032782A1 (en) * | 2022-08-12 | 2024-02-15 | Jacobio Pharmaceuticals Co.Ltd. | Vaccine adjuvants and uses thereof |
| TW202615010A (zh) * | 2024-06-24 | 2026-04-16 | 大陸商北京加科思新藥研發有限公司 | 藥物連接子、其偶聯物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10793557B2 (en) | 2018-04-03 | 2020-10-06 | Merck Sharp & Dohme Corp. | Sting agonist compounds |
| US11702430B2 (en) * | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
| DK4004002T3 (da) * | 2019-07-22 | 2024-09-30 | Lupin Ltd | Makrocykliske forbindelser som sting-agonister samt fremgangsmåder og anvendelser dermed |
-
2022
- 2022-03-29 US US18/284,897 patent/US20240116909A1/en active Pending
- 2022-03-29 EP EP22778907.0A patent/EP4313962B1/en active Active
- 2022-03-29 UY UY0001039705A patent/UY39705A/es unknown
- 2022-03-29 CN CN202280023908.7A patent/CN117203194A/zh active Pending
- 2022-03-29 TW TW111112050A patent/TW202302579A/zh unknown
- 2022-03-29 WO PCT/CN2022/083557 patent/WO2022206725A1/en not_active Ceased
- 2022-03-29 JP JP2023560282A patent/JP2024511832A/ja active Pending
- 2022-03-29 AR ARP220100748A patent/AR125608A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR125608A1 (es) | 2023-08-02 |
| EP4313962B1 (en) | 2026-07-22 |
| CN117203194A (zh) | 2023-12-08 |
| EP4313962A4 (en) | 2025-02-26 |
| UY39705A (es) | 2022-10-31 |
| JP2024511832A (ja) | 2024-03-15 |
| WO2022206725A1 (en) | 2022-10-06 |
| EP4313962A1 (en) | 2024-02-07 |
| US20240116909A1 (en) | 2024-04-11 |
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