TW202237844A - Ｒｎａ製造 - Google Patents
Ｒｎａ製造 Download PDFInfo
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- TW202237844A TW202237844A TW110145636A TW110145636A TW202237844A TW 202237844 A TW202237844 A TW 202237844A TW 110145636 A TW110145636 A TW 110145636A TW 110145636 A TW110145636 A TW 110145636A TW 202237844 A TW202237844 A TW 202237844A
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- rna
- triphosphate
- functional
- utp
- gtp
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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| AU2022282559A1 (en) * | 2021-05-26 | 2024-01-04 | Etherna Immunotherapies Nv | Method to reduce double stranded rna by-product formation |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| WO2023025404A1 (en) | 2021-08-24 | 2023-03-02 | BioNTech SE | In vitro transcription technologies |
| JP2026506504A (ja) * | 2023-02-01 | 2026-02-25 | ジェンスクリプト ユーエスエー インク | インビトロ転写方法及びそのための化合物 |
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| WO2025170909A1 (en) * | 2024-02-05 | 2025-08-14 | The Broad Institute, Inc. | Nucleic acids with region-specific modifications and methods of making the same |
| WO2025223684A1 (en) * | 2024-04-23 | 2025-10-30 | BioNTech SE | Methods and compositions for stimulating immune response |
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| WO1995008626A1 (en) | 1993-09-20 | 1995-03-30 | The Regents Of The University Of Colorado | Strategy for the production of rna from immobilized templates |
| US7074596B2 (en) | 2002-03-25 | 2006-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse mRNA cap analogues |
| US8304529B2 (en) | 2006-07-28 | 2012-11-06 | Life Technologies Corporation | Dinucleotide MRNA cap analogs |
| CN104072561B (zh) | 2007-06-19 | 2017-12-22 | 路易斯安那州州立大学及农业机械学院管理委员会 | 信使rna帽的抗‑反向硫代磷酸类似物的合成和用途 |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| DE102008061522A1 (de) | 2008-12-10 | 2010-06-17 | Biontech Ag | Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2013059475A1 (en) | 2011-10-18 | 2013-04-25 | Life Technologies Corporation | Alkynyl-derivatized cap analogs, preparation and uses thereof |
| EP3155129B1 (en) * | 2014-06-10 | 2019-01-16 | CureVac AG | Method for enhancing rna production |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| CN120842296A (zh) | 2015-09-21 | 2025-10-28 | 垂林克生物技术有限公司 | 用于合成5’-加帽rna的组合物和方法 |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| CN116144626A (zh) | 2016-01-13 | 2023-05-23 | 新英格兰生物实验室公司 | T7 rna聚合酶的热稳定变体 |
| US10337051B2 (en) * | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| US10960070B2 (en) | 2016-10-25 | 2021-03-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion coronavirus spike proteins and their use |
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