TW202214569A - Composition and product thereof - Google Patents

Abstract

The invention relates to a composition and product thereof. The composition includes arecoline and acid. The pH value of the composition is low, and its irritation is weak. The use of the composition is convenient and it has wide range of application.

Description

Compositions and products thereof

The invention belongs to the technical field of chemical synthesis, and relates to a composition and its products.

Arecoline, chemical name "1,2,5,6-tetrahydro-1-methyl-3-picolinate methyl ester", oily liquid, has cholinergic effect. Arecoline is a compound with great application value, and its preparation method and application have always attracted people's attention.

A first aspect of the present invention provides a composition comprising arecoline and an acid.

In some embodiments, the acid is selected from at least one of the following: formic acid, acetic acid, propionic acid, butyric acid, isovaleric acid, 2-methylbutyric acid, valeric acid, 3-methylvaleric acid, 2-methylvaleric acid Base-2-pentenoic acid, trans-2-hexenoic acid, hexanoic acid, heptanoic acid, octanoic acid, 2-nonenoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, octadecanoic acid, peanut acid, benzoic acid, salicylic acid, oxalic acid, citric acid, sorbic acid, tartaric acid, adipic acid, hydrochloric acid, hydrobromic acid, glycine, alanine, valine, leucine, isoleucine, methyl Thiamine (methionine), phenylalanine, proline, tryptophan, serine, tyrosine, cysteine, methionine, aspartamine, glutamine, threonine , Aspartic acid, glutamic acid, lysine, arginine, histidine.

In some embodiments, the molar ratio of the arecoline to the acid is n; wherein, the value range of the n is 0<n≦10, preferably 0<n≦8, and more preferably 0<n≦6, more preferably 0<n≦5, still more preferably 0<n≦3, still more preferably 0<n≦2.

In some embodiments, the arecoline and the acid form an arecoline salt.

A second aspect of the present invention provides an betel nut-flavored product comprising the composition of the first aspect.

In some embodiments, the article is an aerosol-forming substrate for being nebulized to generate an aerosol for ingestion.

In some embodiments, the aerosol-forming substrate is a liquid phase for atomization to generate Aerosol.

In some embodiments, the aerosol-generating substrate is a solid phase configured to generate an aerosol for inhalation when heated below the ignition point.

In some embodiments, the article is a popping bead for use in an aerosol-generating article.

In some embodiments, the article is chewing gum.

The present invention will be further described with reference to the following examples.

Embodiment 1:

Embodiment 1 of the present invention provides a composition comprising arecoline and an acid.

In some embodiments, the acid is selected from at least one of the following: formic acid, acetic acid, propionic acid, butyric acid, isovaleric acid, 2-methylbutyric acid, valeric acid, 3-methylvaleric acid, 2-methylvaleric acid Base-2-pentenoic acid, trans-2-hexenoic acid, hexanoic acid, heptanoic acid, octanoic acid, 2-nonenoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, octadecanoic acid, peanut acid, benzoic acid, salicylic acid, oxalic acid, citric acid, sorbic acid, tartaric acid, adipic acid, hydrochloric acid, hydrobromic acid, glycine, alanine, valine, leucine, isoleucine, methyl Thiamine (methionine), phenylalanine, proline, tryptophan, serine, tyrosine, cysteine, methionine, aspartamine, glutamine, threonine , Aspartic acid, glutamic acid, lysine, arginine, histidine.

In some embodiments, the molar ratio of the arecoline to the acid is n; wherein, the value range of the n is 0<n≦10, preferably 0<n≦8, and more preferably 0<n≦6, more preferably 0<n≦5, still more preferably 0<n≦3, still more preferably 0<n≦2.

In some embodiments, the arecoline and the acid form an arecoline salt.

In this embodiment, the arecoline and the acid are stabilized in the composition in the form of the arecoline salt. The composition includes one or more of arecoline, acid, solvent, and arecoline salt.

During preparation, the arecoline and the acid in different molar ratios are weighed, and the composition is obtained by mixing and stirring.

The prepared composition has low pH value, weak irritation, convenient use and wide use range.

Embodiment 2:

The second embodiment of the present invention provides a use of the composition described in the first embodiment in preparing an aerosol-forming substrate.

In some embodiments, when preparing the aerosol-forming substrate, based on the total mass of the aerosol-forming substrate, the mass percentage of the arecoline is 0.01%-10%, preferably 0.2%-10%, More preferably, it is 1% to 10%, more preferably 1% to 5%, still more preferably 1% to 4%, still more preferably 1% to 3%, and still more preferably 1% to 2%.

In some embodiments, when preparing the aerosol-forming substrate, based on the total mass of the aerosol-forming substrate, the mass percentage of the acid is 0.01%-10%, preferably 0.2%-10%, and further It is preferably 1% to 10%, more preferably 1% to 5%, still more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, when preparing the aerosol-forming substrate, the item added to the composition includes a solvent.

In some embodiments, the solvent is selected from at least one of the following: 1,2-propanediol, 1,3-propanediol, glycerol, polyethylene glycol 200, polyethylene glycol 400, dipropylene glycol acetal, ethanol, water , Triethyl citrate, triacetin, caprylic acid glyceride, isopropyl alcohol, orange oil, lemon oil, peppermint oil, palm oil, peanut oil, corn oil, salad oil.

In some embodiments, the solvent includes glycerol, and the mass percentage of the glycerol is 0-90%.

In some embodiments, the solvent includes propylene glycol, and the mass percentage of the propylene glycol is 9% to 99.8%.

In some embodiments, when preparing the aerosol-forming substrate, the items added to the composition further include a cooling agent.

In some embodiments, the cooling agent is selected from at least one of the following: N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N,2,3-trimethyl-2 -Isopropylbutanamide, N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide.

In some embodiments, the item added to the composition further includes a fragrance.

In some embodiments, the fragrance is selected from at least one of: nerol, trans-2-hexenol, linalool, benzyl alcohol, 1-hexanol, leaf alcohol, alpha-terpineol, incense maltol, beta-phenethyl alcohol, linalool oxide, geraniol, isoamyl alcohol, octanol, hexanol, decyl alcohol, cinnamyl alcohol, heptanol, eugenol, maltol, ethyl maltol, thyme Phenol, isoeugenol, 2-methylbutyric acid, malic acid, n-valeric acid, n-hexanoic acid, edible acetic acid, n-octanoic acid, strawberry acid, butyric acid, citric acid, propionic acid, 3-methylvaleric acid, isopentyl acid, isoamyl acetate, amyl formate, geranyl formate, butyl formate, benzyl formate, folate formate, gamma-decalactone, butyl-nononolactone, gamma-caprylactone, gamma-enantholactone , gamma-undecalactone, butyl-dodecalactone, benzaldehyde, strawberry aldehyde, cinnamaldehyde, furfural, citral, acetaldehyde, 3-methylthiopropanal, natural 3-mercapto-2-methylpentanal Aldehyde, isobutyraldehyde, trans-2-octenal, trans-2-nonenal, trans-2-decenal, trans,trans-2,4-heptadienal, 2,5-dimethyl Pyrazine, 2-Acetylfuran, 2-ethyl-3(5 or 6)-dimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-trimethylpyrazine Pyrazine, 2-Acetylpyrazine, Acetophenone, β-Ionone, Trakelenone No. 2 (Firmenich), Butanedione, M-Ionone, Acetoin (Acetyl Methyl alcohol), acetoin (acetyl methyl alcohol), methyl heptenone, vanillin, ethyl vanillin, dihydrocoumarin, raspberry ketone, anisole, methyl cedar ether, methyl alcohol Alkyl-2-methyl-3-furyl disulfide, oil of wintergreen, oil of clove buds, oil of tenfold orange, rosewood oil, geranium oil, oil of bitter almond, oil of clove basil, ethyl vanillin, dimethicone Hydrocoumarin, Raspberry Ketone, Rich Vanillin, Turmeric Extract, Peruvian Extract, Oak Extract, Espresso Supercritical Extract (Water Soluble), Cocoa Extract, Coffee Tincture, Duhuo Tincture, Pandan extract, vanilla extract, labdanum extract, iris oil or extract, jasmine extract, tree moss extract (amber), tamarind extract, zimbabwe extract, tobacco essential oil, burley Extract, flue-cured tobacco pure oil A, flue-cured tobacco butt incense extract, sun-cured tobacco butt incense extract.

It should be noted that the flavoring agent is not limited to the substances listed above, and all flavoring agents complying with the FEMA code and the CAS code can be applied.

In some embodiments, the articles added to the composition do not contain nicotine and/or nicotine salts.

Embodiment three:

The third embodiment of the present invention provides an aerosol-forming substrate, and the aerosol-forming substrate includes the composition and the solvent described in the first embodiment.

In some embodiments, based on the total mass of the aerosol-forming substrate, the mass percentage of the arecoline is 0.01%-10%, preferably 0.2%-10%, more preferably 1%-10%, further preferably It is 1% to 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, the mass percentage of the acid is 0.01%-10%, preferably 0.2%-10%, more preferably 1%-10%, further preferably 1%-5%, further preferably 1% % to 4%, more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, the solvent is selected from at least one of the following: 1,2-propanediol, 1,3-propanediol, glycerol, polyethylene glycol 200, polyethylene glycol 400, dipropylene glycol acetal, ethanol, water , Triethyl citrate, triacetin, caprylic acid glyceride, isopropyl alcohol, orange oil, lemon oil, peppermint oil, palm oil, peanut oil, corn oil, salad oil.

In some embodiments, the solvent includes glycerol, and the mass percentage of glycerol in the aerosol-forming substrate is 0-90%.

In some embodiments, the solvent includes propylene glycol, and the mass percentage of propylene glycol in the aerosol-forming substrate is 9% to 99.8%.

In some embodiments, the aerosol-forming substrate further includes a cooling agent.

In some embodiments, the cooling agent is selected from at least one of the following: N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N,2,3-trimethyl-2 -Isopropylbutanamide, N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide.

In some embodiments, the aerosol-forming substrate further includes a fragrance.

In some embodiments, the fragrance is selected from at least one of: nerol, trans-2-hexenol, linalool, benzyl alcohol, 1-hexanol, leaf alcohol, alpha-terpineol, incense maltol, beta-phenethyl alcohol, linalool oxide, geraniol, isoamyl alcohol, octanol, hexanol, decyl alcohol, cinnamyl alcohol, heptanol, eugenol, maltol, ethyl maltol, thyme Phenol, isoeugenol, 2-methylbutyric acid, malic acid, n-valeric acid, n-hexanoic acid, edible acetic acid, n-octanoic acid, strawberry acid, butyric acid, citric acid, propionic acid, 3-methylvaleric acid, isopentyl acid, isoamyl acetate, amyl formate, geranyl formate, butyl formate, benzyl formate, folate formate, gamma-decalactone, butyl-nononolactone, gamma-caprylactone, gamma-enantholactone , gamma-undecalactone, butyl-dodecalactone, benzaldehyde, strawberry aldehyde, cinnamaldehyde, furfural, citral, acetaldehyde, 3-methylthiopropanal, natural 3-mercapto-2-methylpentanal Aldehyde, isobutyraldehyde, trans-2-octenal, trans-2-nonenal, trans-2-decenal, trans,trans-2,4-heptadienal, 2,5-dimethyl Pyrazine, 2-Acetylfuran, 2-ethyl-3(5 or 6)-dimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-trimethylpyrazine Pyrazine, 2-Acetylpyrazine, Acetophenone, β-Ionone, Trakelenone No. 2 (Firmenich), Butanedione, M-Ionone, Acetoin (Acetyl Methyl alcohol), acetoin (acetyl methyl alcohol), methyl heptenone, vanillin, ethyl vanillin, dihydrocoumarin, raspberry ketone, anisole, methyl cedar ether, methyl alcohol Alkyl-2-methyl-3-furyl disulfide, oil of wintergreen, oil of clove buds, oil of tenfold orange, rosewood oil, geranium oil, oil of bitter almond, oil of clove basil, ethyl vanillin, dimethicone Hydrocoumarin, Raspberry Ketone, Rich Vanillin, Turmeric Extract, Peruvian Extract, Oak Extract, Espresso Supercritical Extract (Water Soluble), Cocoa Extract, Coffee Tincture, Duhuo Tincture, Pandan extract, vanilla extract, labdanum extract, iris oil or extract, jasmine extract, tree moss extract (amber), tamarind extract, zimbabwe extract, tobacco essential oil, burley Extract, flue-cured tobacco pure oil A, flue-cured tobacco butt incense extract, sun-cured tobacco butt incense extract.

It should be noted that the flavoring agent is not limited to the substances listed above, and all flavoring agents complying with the FEMA code and the CAS code can be applied.

In some embodiments, the aerosol-forming matrix is free of nicotine and/or nicotine salts.

Example 1:

The aerosol-forming base was prepared according to the following formula: propylene glycol 566.6 g, glycerol 400 g, benzoic acid 16.7 g, arecoline 16.7 g.

Preparation method: weigh the benzoic acid and arecoline of the above formula weight, add them to propylene glycol under stirring, add glycerin of the formula amount, stir and filter, and then bottle.

Example 2:

The aerosol-forming base was prepared according to the following formula: propylene glycol 569.8 g, glycerol 400 g, benzoic acid 13.5 g, arecoline 16.7 g.

Preparation method: weigh the benzoic acid and arecoline of the above formula weight, add them to propylene glycol under stirring, add glycerin of the formula amount, stir and filter, and then bottle.

Example 3:

The aerosol-forming base was prepared according to the following formula: propylene glycol 570.8 g, glycerol 400 g, benzoic acid 12.5 g, arecoline 16.7 g.

Preparation method: weigh the benzoic acid and arecoline of the above formula weight, add them to propylene glycol under stirring, add glycerin of the formula amount, stir and filter, and then bottle.

Comparative Example 1:

The aerosol-forming base was prepared according to the following formula: 583.3 g of propylene glycol, 400 g of glycerol, and 16.7 g of arecoline.

Preparation method: weigh arecoline in the above formula weight, add it to propylene glycol under stirring, add glycerin in the formula amount, stir and filter, and then bottle.

The pH value test was carried out on the aerosol-forming substrates prepared in Examples 1-3 and Comparative Example 1; at the same time, the aerosol-forming substrates prepared in Examples 1-3 and Comparative Example 1 were subjected to multiple smoking in terms of irritation. Inhalation judgment, the judging standard is: the total score is 10 points, 1-5 points for weak stimulation, 6-7 points for moderate stimulation, 8-10 points for strong stimulation; the average score is taken.

The test results are shown in the following table: Numbering formula pH stimulus score Example 1 Propylene glycol 566.6g, glycerin 400g, benzoic acid 16.7g, arecoline 16.7g 6.1 4 Example 2 Propylene glycol 569.8g, glycerin 400g, benzoic acid 13.5g, arecoline 16.7g 6.5 5 Example 3 Propylene glycol 570.8g, glycerin 400g, benzoic acid 12.5g, arecoline 16.7g 6.7 6 Comparative Example 1 Propylene Glycol 583.3g, Glycerin 400g, Arecoline 16.7g 9.4 9

It can be seen from the above test results that the pH value of the aerosol-forming substrate with benzoic acid is lower than that of the aerosol-forming substrate prepared in Comparative Example 1.

In addition, after the aerosol-forming substrate is atomized into an aerosol, the smoker can ingest arecoline, which is less irritating and can produce a similar effect of chewing betel nut.

Embodiment four:

Embodiment 4 of the present invention provides an aerosol generating system, including an atomizing device and the aerosol-forming substrate described in Embodiment 3;

The atomizing device is configured to atomize the aerosol-forming substrate to form an aerosol.

In some embodiments, the atomizing device is a heated atomizing device.

In some embodiments, the nebulizing device is an ultrasonic nebulizing device.

In some embodiments, the aerosol-forming base includes arecoline, benzoic acid, glycerol, and propylene glycol.

In some embodiments, the aerosol-forming matrix includes arecoline, benzoic acid, glycerol, and water.

In some embodiments, the aerosol-forming base includes arecoline, benzoic acid, and palm oil.

In some embodiments, the oscillation frequency of the ultrasonic atomizing device is greater than 1 MHz.

In some embodiments, the atomizing device is an air-compressed atomizing device or a press-type atomizing device.

In some embodiments, the aerosol-forming matrix includes arecoline, benzoic acid, and water.

In some embodiments, the aerosol-forming matrix includes arecoline, benzoic acid, glycerol, and water.

In some embodiments, the aerosol-forming base includes arecoline, benzoic acid, and palm oil.

Embodiment five:

The fifth embodiment of the present invention provides a use of the composition described in the first embodiment in the manufacture of an aerosol-generating product.

Among others, the aerosol-generating article is intended to be heated to generate an aerosol for ingestion.

In some embodiments, when manufacturing the aerosol-generating product, based on the total mass of the raw materials of the aerosol-generating product, the mass percentage of the arecoline is 0.01% to 10%, preferably 0.2% to 10%. %, more preferably 1% to 10%, still more preferably 1% to 5%, still more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, when manufacturing the aerosol-generating product, based on the total mass of the raw materials of the aerosol-generating product, the mass percentage of the acid is 0.01%-10%, preferably 0.2%-10% , more preferably 1% to 10%, still more preferably 1% to 5%, still more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, when making the aerosol-generating article, the items added to the composition include aerosols, binders, and vegetable fibers.

In some embodiments, the nebulizer is selected from at least one of the following: 1,2-propanediol, 1,3-propanediol, glycerol, polyethylene glycol 200, polyethylene glycol 400, dipropylene glycol acetal, ethanol , water, triethyl citrate, triacetin, caprylic glyceride, isopropyl alcohol, orange oil, lemon oil, peppermint oil, palm oil, peanut oil, corn oil, salad oil.

In some embodiments, when manufacturing the aerosol-generating product, based on the total mass of the raw materials of the aerosol-generating product, the mass percentage of the atomizing agent is 5% to 30%, preferably 10% to 30%. 30%, more preferably 10% to 25%, still more preferably 15% to 25%.

In some embodiments, the binder is selected from at least one of the following: carboxymethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl alcohol, rosin, xanthan gum, gum arabic, guar gum, chitosan Sugar, pectin, locust bean gum, starch, sodium alginate, shellac.

In some embodiments, when manufacturing the aerosol-generating product, based on the total mass of the raw materials of the aerosol-generating product, the mass percentage of the binder is 1%-20%, preferably 1%-15% %, more preferably 1% to 10%, still more preferably 3% to 10%, still more preferably 5% to 10%.

In some embodiments, the plant fiber is selected from at least one of the following: betel nut fiber, wood pulp fiber, hemp pulp fiber, cotton pulp fiber, bagasse pulp fiber, bamboo pulp fiber, coconut pulp fiber.

In some embodiments, when manufacturing the aerosol-generating product, based on the total mass of the raw materials of the aerosol-generating product, the mass percentage of the plant fiber is 40% to 80%, preferably 40% to 70%. %, more preferably 50% to 70%, still more preferably 50% to 65%, still more preferably 50% to 60%.

In some embodiments, the item added to the composition further includes a fragrance.

In some embodiments, the fragrance is selected from at least one of: nerol, trans-2-hexenol, linalool, benzyl alcohol, 1-hexanol, leaf alcohol, alpha-terpineol, incense maltol, beta-phenethyl alcohol, linalool oxide, geraniol, isoamyl alcohol, octanol, hexanol, decyl alcohol, cinnamyl alcohol, heptanol, eugenol, maltol, ethyl maltol, thyme Phenol, isoeugenol, 2-methylbutyric acid, malic acid, n-valeric acid, n-hexanoic acid, edible acetic acid, n-octanoic acid, strawberry acid, butyric acid, citric acid, propionic acid, 3-methylvaleric acid, isopentyl acid, isoamyl acetate, amyl formate, geranyl formate, butyl formate, benzyl formate, folate formate, gamma-decalactone, butyl-nononolactone, gamma-caprylactone, gamma-enantholactone , gamma-undecalactone, butyl-dodecalactone, benzaldehyde, strawberry aldehyde, cinnamaldehyde, furfural, citral, acetaldehyde, 3-methylthiopropanal, natural 3-mercapto-2-methylpentanal Aldehyde, isobutyraldehyde, trans-2-octenal, trans-2-nonenal, trans-2-decenal, trans,trans-2,4-heptadienal, 2,5-dimethyl Pyrazine, 2-Acetylfuran, 2-ethyl-3(5 or 6)-dimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-trimethylpyrazine Pyrazine, 2-Acetylpyrazine, Acetophenone, β-Ionone, Trakelenone No. 2 (Firmenich), Butanedione, M-Ionone, Acetoin (Acetyl Methyl alcohol), acetoin (acetyl methyl alcohol), methyl heptenone, vanillin, ethyl vanillin, dihydrocoumarin, raspberry ketone, anisole, methyl cedar ether, methyl alcohol Alkyl-2-methyl-3-furyl disulfide, oil of wintergreen, oil of clove buds, oil of tenfold orange, rosewood oil, geranium oil, oil of bitter almond, oil of clove basil, ethyl vanillin, dimethicone Hydrocoumarin, Raspberry Ketone, Rich Vanillin, Turmeric Extract, Peruvian Extract, Oak Extract, Espresso Supercritical Extract (Water Soluble), Cocoa Extract, Coffee Tincture, Duhuo Tincture, Pandan extract, vanilla extract, labdanum extract, iris oil or extract, jasmine extract, tree moss extract (amber), tamarind extract, zimbabwe extract, tobacco essential oil, burley Extract, flue-cured tobacco pure oil A, flue-cured tobacco butt incense extract, sun-cured tobacco butt incense extract.

It should be noted that the flavoring agent is not limited to the substances listed above, and all flavoring agents complying with the FEMA code and the CAS code can be applied.

In some embodiments, the articles added to the composition do not contain tobacco components.

In some embodiments, the method of making the aerosol-generating article includes one of a papermaking method, a dry-laid papermaking method, a thick stock method, and a rolling method.

Embodiment six:

Embodiment 6 of the present invention provides an aerosol-generating product, the raw materials of which include the composition described in Embodiment 1, an atomizing agent, an adhesive, and a plant fiber.

Among others, the aerosol-generating article is intended to be heated to generate an aerosol for ingestion.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the arecoline is 0.01% to 10%, preferably 0.2% to 10%, more preferably 1% to 10%, further preferably 1% ∼5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the acid is 0.01% to 10%, preferably 0.2% to 10%, more preferably 1% to 10%, and further preferably 1% to 10%. 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, the nebulizer is selected from at least one of the following: 1,2-propanediol, 1,3-propanediol, glycerol, polyethylene glycol 200, polyethylene glycol 400, dipropylene glycol acetal, ethanol , water, triethyl citrate, triacetin, caprylic glyceride, isopropyl alcohol, orange oil, lemon oil, peppermint oil, palm oil, peanut oil, corn oil, salad oil.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the atomizing agent is 5%-30%, preferably 10%-30%, more preferably 10%-25%, further preferably 15% % to 25%.

In some embodiments, the binder is selected from at least one of the following: carboxymethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl alcohol, rosin, xanthan gum, gum arabic, guar gum, shell Polysaccharides, pectin, locust bean gum, starch, sodium alginate, shellac.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the binder is 1%-20%, preferably 1%-15%, more preferably 1%-10%, further preferably 3% ~10%, more preferably 5% to 10%.

In some embodiments, the plant fiber is selected from at least one of the following: betel nut fiber, wood pulp fiber, hemp pulp fiber, cotton pulp fiber, bagasse pulp fiber, bamboo pulp fiber, coconut pulp fiber.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the plant fiber is 40%-80%, preferably 40%-70%, more preferably 50%-70%, further preferably 50% to 65%, more preferably 50 to 60%.

In some embodiments, the feedstock further includes a fragrance.

In some embodiments, the fragrance is selected from at least one of: nerol, trans-2-hexenol, linalool, benzyl alcohol, 1-hexanol, leaf alcohol, alpha-terpineol, incense maltol, beta-phenethyl alcohol, linalool oxide, geraniol, isoamyl alcohol, octanol, hexanol, decyl alcohol, cinnamyl alcohol, heptanol, eugenol, maltol, ethyl maltol, thyme Phenol, isoeugenol, 2-methylbutyric acid, malic acid, n-valeric acid, n-hexanoic acid, edible acetic acid, n-octanoic acid, strawberry acid, butyric acid, citric acid, propionic acid, 3-methylvaleric acid, isopentyl acid, isoamyl acetate, amyl formate, geranyl formate, butyl formate, benzyl formate, folate formate, gamma-decalactone, butyl-nononolactone, gamma-caprylactone, gamma-enantholactone , gamma-undecalactone, butyl-dodecalactone, benzaldehyde, strawberry aldehyde, cinnamaldehyde, furfural, citral, acetaldehyde, 3-methylthiopropanal, natural 3-mercapto-2-methylpentanal Aldehyde, isobutyraldehyde, trans-2-octenal, trans-2-nonenal, trans-2-decenal, trans,trans-2,4-heptadienal, 2,5-dimethyl Pyrazine, 2-Acetylfuran, 2-ethyl-3(5 or 6)-dimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-trimethylpyrazine Pyrazine, 2-Acetylpyrazine, Acetophenone, β-Ionone, Trakelenone No. 2 (Firmenich), Butanedione, M-Ionone, Acetoin (Acetyl Methyl alcohol), acetoin (acetyl methyl alcohol), methyl heptenone, vanillin, ethyl vanillin, dihydrocoumarin, raspberry ketone, anisole, methyl cedar ether, methyl alcohol Alkyl-2-methyl-3-furyl disulfide, oil of wintergreen, oil of clove buds, oil of tenfold orange, rosewood oil, geranium oil, oil of bitter almond, oil of clove basil, ethyl vanillin, dimethicone Hydrocoumarin, Raspberry Ketone, Rich Vanillin, Turmeric Extract, Peruvian Extract, Oak Extract, Espresso Supercritical Extract (Water Soluble), Cocoa Extract, Coffee Tincture, Duhuo Tincture, Pandan extract, vanilla extract, labdanum extract, iris oil or extract, jasmine extract, tree moss extract (amber), tamarind extract, zimbabwe extract, tobacco essential oil, burley Extract, flue-cured tobacco pure oil A, flue-cured tobacco butt incense extract, sun-cured tobacco butt incense extract.

It should be noted that the flavoring agent is not limited to the substances listed above, and all flavoring agents complying with the FEMA code and the CAS code can be applied.

In some embodiments, the feedstock does not contain tobacco components.

Example 1:

To prepare heat not burn cigarettes, follow these steps:

Step 1: Preparation of the sheet substrate. Select the solid residue of betel nut extract, soak it in water, the water temperature is 60～80 ℃, the soaking time is 0.5～2h, filter, and then the filtered solid is beaten to obtain a slurry, and the slurry is weighed in parts by weight 50～70 parts, 3-10 parts of solid binder, mix evenly, send the mixed slurry to a paper machine for molding, and dry to a moisture content of about 10-15% to obtain a sheet base;

Wherein, the solid binder can be carboxymethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl alcohol, rosin, xanthan gum, gum arabic, guar gum, chitosan, pectin, locust bean gum, starch , one or more of sodium alginate and shellac.

Step 2: Prepare a coating solution. Weigh 1 to 50 parts of benzoic acid, 1 to 50 parts of arecoline, 2 to 20 parts of spice, and 40 to 80 parts of atomizing agent by weight, and mix them evenly to obtain a coating solution;

Wherein, the atomizing agent is a mixture of glycerol and propylene glycol, and the mixing ratio is 3-5:1.

Step 3: Coating the sheet substrate. Weigh the coating solution obtained in step 2 according to 25% to 40% of the weight of the sheet base obtained in step 1, spray the coating solution on the sheet base, and stand for 40 to 60 hours under constant temperature and humidity conditions to obtain a plant containing the composition. flakes;

Step 4: Preparation of heat-not-burn cigarettes. The plant flakes obtained in step 3 are made into cigarette sticks according to the size, and the cigarette sticks are connected with the filter tip to obtain heat-not-burn cigarettes containing the composition.

The heat-not-burn cigarettes prepared by the above preparation method are smoked with ordinary heat-not-burn cigarettes (the aerosol generating device and its heating method are not particularly limited, and resistance heating, electromagnetic heating, infrared radiation heating, etc. etc.) and sensory quality evaluation: the heat-not-burn cigarettes prepared by the above preparation method can ingest arecoline and produce similar effects of chewing betel nut, with lower irritation.

Embodiment 7:

Embodiment 7 of the present invention provides a use of the composition described in Embodiment 1 in preparing a liquid composition for explosive beads; wherein, the explosive beads include a frangible shell and the liquid composition, and the liquid composition disposed within the frangible housing.

In some embodiments, based on the total mass of the liquid composition, the mass percentage of the arecoline is 0.01% to 10%, preferably 0.2% to 10%, more preferably 1% to 10%, further preferably 1% to 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, based on the total mass of the liquid composition, the mass percentage of the acid is 0.01%-10%, preferably 0.2%-10%, more preferably 1%-10%, further preferably 1% % to 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, when the liquid composition is prepared, the items added to the composition include an atomizing agent.

In some embodiments, the nebulizer is selected from at least one of the following: 1,2-propanediol, 1,3-propanediol, glycerol, polyethylene glycol 200, polyethylene glycol 400, dipropylene glycol acetal, ethanol , water, triethyl citrate, triacetin, caprylic glyceride, isopropyl alcohol, orange oil, lemon oil, peppermint oil, palm oil, peanut oil, corn oil, salad oil.

In some embodiments, based on the total mass of the liquid composition, the mass percentage of the atomizing agent is 5% to 30%, preferably 10% to 30%, more preferably 10% to 25%, further preferably 15% to 25%.

In some embodiments, the item added to the composition further includes a fragrance.

In some embodiments, the fragrance is selected from at least one of: nerol, trans-2-hexenol, linalool, benzyl alcohol, 1-hexanol, leaf alcohol, alpha-terpineol, incense maltol, beta-phenethyl alcohol, linalool oxide, geraniol, isoamyl alcohol, octanol, hexanol, decyl alcohol, cinnamyl alcohol, heptanol, eugenol, maltol, ethyl maltol, thyme Phenol, isoeugenol, 2-methylbutyric acid, malic acid, n-valeric acid, n-hexanoic acid, edible acetic acid, n-octanoic acid, strawberry acid, butyric acid, citric acid, propionic acid, 3-methylvaleric acid, isopentyl acid, isoamyl acetate, amyl formate, geranyl formate, butyl formate, benzyl formate, folate formate, gamma-decalactone, butyl-nononolactone, gamma-caprylactone, gamma-enantholactone , gamma-undecalactone, butyl-dodecalactone, benzaldehyde, strawberry aldehyde, cinnamaldehyde, furfural, citral, acetaldehyde, 3-methylthiopropanal, natural 3-mercapto-2-methylpentanal Aldehyde, isobutyraldehyde, trans-2-octenal, trans-2-nonenal, trans-2-decenal, trans,trans-2,4-heptadienal, 2,5-dimethyl Pyrazine, 2-Acetylfuran, 2-ethyl-3(5 or 6)-dimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-trimethylpyrazine Pyrazine, 2-Acetylpyrazine, Acetophenone, β-Ionone, Trakelenone No. 2 (Firmenich), Butanedione, M-Ionone, Acetoin (Acetyl Methyl alcohol), acetoin (acetyl methyl alcohol), methyl heptenone, vanillin, ethyl vanillin, dihydrocoumarin, raspberry ketone, anisole, methyl cedar ether, methyl alcohol Alkyl-2-methyl-3-furyl disulfide, oil of wintergreen, oil of clove bud, oil of tenfold sweet orange, rosewood oil, geranium oil, oil of bitter almond, oil of clove basil, ethyl vanillin, dimethicone Hydrocoumarin, Raspberry Ketone, Rich Vanillin, Turmeric Extract, Peruvian Extract, Oak Extract, Espresso Supercritical Extract (Water Soluble), Cocoa Extract, Coffee Tincture, Duhuo Tincture, Pandan extract, vanilla extract, labdanum extract, iris oil or extract, jasmine extract, tree moss extract (amber), tamarind extract, zimbabwe extract, tobacco essential oil, burley Extract, flue-cured tobacco pure oil A, flue-cured tobacco butt incense extract, sun-cured tobacco butt incense extract.

It should be noted that the flavoring agent is not limited to the substances listed above, and all flavoring agents complying with the FEMA code and the CAS code can be applied.

In some embodiments, the articles added to the composition do not contain nicotine and/or nicotine salts.

In some embodiments, the explosive beads are embedded in an aerosol-generating article.

In some embodiments, the raw material of the aerosol-generating article does not contain tobacco components.

Embodiment eight:

The eighth embodiment of the present invention provides an explosive bead, comprising a frangible shell and a liquid composition, and the liquid composition is arranged in the frangible shell;

Wherein, the liquid composition includes the composition described in Embodiment 1 and an atomizing agent.

In some embodiments, based on the total mass of the liquid composition, the mass percentage of the arecoline is 0.01% to 10%, preferably 0.2% to 0%, more preferably 1% to 10%, further preferably 1% to 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, based on the total mass of the liquid composition, the mass percentage of the acid is 0.01%-10%, preferably 0.2%-10%, more preferably 1%-10%, further preferably 1% % to 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, the nebulizer is selected from at least one of the following: 1,2-propanediol, 1,3-propanediol, glycerol, polyethylene glycol 200, polyethylene glycol 400, dipropylene glycol acetal, ethanol , water, triethyl citrate, triacetin, caprylic glyceride, isopropyl alcohol, orange oil, lemon oil, peppermint oil, palm oil, peanut oil, corn oil, salad oil.

In some embodiments, based on the total mass of the liquid composition, the mass percentage of the atomizing agent is 5% to 30%, preferably 10% to 30%, more preferably 10% to 25%, further preferably 15% to 25%.

In some embodiments, the liquid composition further includes a fragrance.

In some embodiments, the fragrance is selected from at least one of: nerol, trans-2-hexenol, linalool, benzyl alcohol, 1-hexanol, leaf alcohol, alpha-terpineol, incense maltol, beta-phenethyl alcohol, linalool oxide, geraniol, isoamyl alcohol, octanol, hexanol, decyl alcohol, cinnamyl alcohol, heptanol, eugenol, maltol, ethyl maltol, thyme Phenol, isoeugenol, 2-methylbutyric acid, malic acid, n-valeric acid, n-hexanoic acid, edible acetic acid, n-octanoic acid, strawberry acid, butyric acid, citric acid, propionic acid, 3-methylvaleric acid, isopentyl acid, isoamyl acetate, amyl formate, geranyl formate, butyl formate, benzyl formate, folate formate, gamma-decalactone, butyl-nononolactone, gamma-caprylactone, gamma-enantholactone , gamma-undecalactone, butyl-dodecalactone, benzaldehyde, strawberry aldehyde, cinnamaldehyde, furfural, citral, acetaldehyde, 3-methylthiopropanal, natural 3-mercapto-2-methylpentanal Aldehyde, isobutyraldehyde, trans-2-octenal, trans-2-nonenal, trans-2-decenal, trans,trans-2,4-heptadienal, 2,5-dimethyl Pyrazine, 2-Acetylfuran, 2-ethyl-3(5 or 6)-dimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-trimethylpyrazine Pyrazine, 2-Acetylpyrazine, Acetophenone, β-Ionone, Trakelenone No. 2 (Firmenich), Butanedione, M-Ionone, Acetoin (Acetyl Methyl alcohol), acetoin (acetyl methyl alcohol), methyl heptenone, vanillin, ethyl vanillin, dihydrocoumarin, raspberry ketone, anisole, methyl cedar ether, methyl alcohol Alkyl-2-methyl-3-furyl disulfide, oil of wintergreen, oil of clove bud, oil of tenfold sweet orange, rosewood oil, geranium oil, oil of bitter almond, oil of clove basil, ethyl vanillin, dimethicone Hydrocoumarin, Raspberry Ketone, Rich Vanillin, Turmeric Extract, Peruvian Extract, Oak Extract, Espresso Supercritical Extract (Water Soluble), Cocoa Extract, Coffee Tincture, Duhuo Tincture, Pandan extract, vanilla extract, labdanum extract, iris oil or extract, jasmine extract, tree moss extract (amber), tamarind extract, zimbabwe extract, tobacco essential oil, burley Extract, flue-cured tobacco pure oil A, flue-cured tobacco butt incense extract, sun-cured tobacco butt incense extract.

It should be noted that the flavoring agent is not limited to the substances listed above, and all flavoring agents complying with the FEMA code and the CAS code can be applied.

In some embodiments, the liquid composition does not contain nicotine and/or nicotine salts.

Embodiment nine:

The ninth embodiment of the present invention provides an aerosol-generating product, including the explosive beads described in the eighth embodiment.

In some embodiments, the raw material of the aerosol-generating article does not contain tobacco components.

In this embodiment, the aerosol-generating article may be prepared using a papermaking method, a dry-laid method, a thick stock method, or a rolling method. Specifically, for the raw materials of the aerosol-generating product and the preparation steps thereof, reference may be made to the contents described in the foregoing embodiments.

Explosive beads can be implanted into the filter section (not limited to this position) of HNB cigarettes through the filter rod embedding technology (not limited to this technology), and when in use, the smoker can squeeze the explosive beads to ingest betel nut Substances such as alkalis.

It should be noted that, in this embodiment, there are no special restrictions on the components of the fragile shell and the preparation process thereof, as well as the preparation process of the explosive beads, and techniques well-known to those with ordinary knowledge in the technical field to which the present invention pertains can be used, namely Can.

Example 1:

The liquid composition in the popped beads was prepared according to the following formula: benzoic acid 5wt%, arecoline 5wt%, caprylic acid glyceride 80wt%, menthol 10wt%.

Preparation method: weigh benzoic acid and arecoline according to the weight of the above formula, add caprylic acid glyceride and menthol under stirring, and make after mixing.

The explosive beads containing Example 1 were implanted into heat-not-burn cigarettes, and the heat-not-burn cigarettes containing no explosive beads were smoked and evaluated for sensory quality: the heat-not-burn cigarettes containing the explosive beads of Example 1 could Arecoline is ingested and produces a similar effect to chewing betel nut with less irritation.

Embodiment ten:

The tenth embodiment of the present invention provides a use of the composition described in the first embodiment in the manufacture of chewing gum.

In some embodiments, when manufacturing the chewing gum, based on the total mass of the raw materials of the chewing gum, the mass percentage of the arecoline is 0.01%-1%, preferably 0.01%-0.8%, more preferably 0.01% % to 0.6%, more preferably 0.01% to 0.5%, still more preferably 0.05% to 0.5%, still more preferably 0.1% to 0.5%, still more preferably 0.2% to 0.5%.

In some embodiments, when manufacturing the chewing gum, based on the total mass of the raw materials of the chewing gum, the mass percentage of the acid is 0.01%-1%, preferably 0.01%-0.8%, more preferably 0.01% ~0.6%, more preferably 0.01% to 0.5%, still more preferably 0.05% to 0.5%, still more preferably 0.1% to 0.5%, still more preferably 0.2% to 0.5%.

In some embodiments, when the chewing gum is manufactured, the item added to the composition includes a gum base.

In some embodiments, when manufacturing the chewing gum, based on the total mass of the raw materials of the chewing gum, the mass percentage of the gum base is 20%-75%, preferably 20%-70%, more preferably 20% % to 60%, more preferably 20% to 50%, still more preferably 25% to 50%, still more preferably 30% to 50%, still more preferably 35% to 50%, still more preferably 35% to 45%.

In some embodiments, the items added to the composition further include a sweetener.

In some embodiments, the sweetener is selected from at least one of the following: white sugar, rock sugar, sucrose, maltose, corn syrup, glucose syrup, fructose, maltodextrin, polydextrose, xylitol, sorbitol , Maltitol, Erythritol, Aspartame, Acesulfame K, Sucralose, Stevioside, Neotame.

In some embodiments, when manufacturing the chewing gum, based on the total mass of the raw materials of the chewing gum, the mass percentage of the sweetener is 20%-75%, preferably 20%-70%, more preferably 20% to 60%, more preferably 20% to 50%, more preferably 25% to 50%, still more preferably 25% to 40%, still more preferably 25% to 35%, still more preferably 30% to 35% .

In some embodiments, the items added to the composition further include filler materials.

In some embodiments, the filler material is selected from at least one of: sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, dicalcium phosphate, sodium dihydrogen phosphate.

In some embodiments, when manufacturing the chewing gum, based on the total mass of the raw materials of the chewing gum, the mass percentage of the filler material is 0.03%-23%, preferably 0.03%-20%, more preferably 0.03% % to 15%, more preferably 0.03% to 10%, more preferably 0.5% to 10%, still more preferably 1% to 10%, still more preferably 1.5% to 10%, further preferably 2% to 8%, More preferably, it is 2% to 6%.

In some embodiments, the items added to the composition further include flavoring agents.

In some embodiments, the flavoring agent is selected from at least one of the following: mint, spearmint, cinnamon, borneol, essence.

Embodiment eleven:

Embodiment 11 of the present invention provides a chewing gum, the raw materials of which include the composition described in Embodiment 1 and a gum base.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the arecoline is 0.01% to 10%, preferably 0.2% to 10%, more preferably 1% to 10%, further preferably 1% ∼5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the acid is 0.01% to 10%, preferably 0.2% to 10%, more preferably 1% to 10%, and further preferably 1% to 10%. 5%, more preferably 1% to 4%, still more preferably 1% to 3%, still more preferably 1% to 2%.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the gum base is 20%-75%, preferably 20%-70%, more preferably 20%-60%, further preferably 20% ~50%, more preferably 25% to 50%, still more preferably 30% to 50%, still more preferably 35% to 50%, still more preferably 35% to 45%.

In some embodiments, the feedstock further includes a sweetener.

In some embodiments, the sweetener is selected from at least one of the following: white sugar, rock sugar, sucrose, maltose, corn syrup, glucose syrup, fructose, maltodextrin, polydextrose, xylitol, sorbitol , Maltitol, Erythritol, Aspartame, Acesulfame K, Sucralose, Stevioside, Neotame.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the sweetener is 20%-75%, preferably 20%-70%, more preferably 20%-60%, further preferably 20% % to 50%, more preferably 25% to 50%, still more preferably 25% to 40%, still more preferably 25% to 35%, still more preferably 30% to 35%.

In some embodiments, the feedstock further includes filler material.

In some embodiments, the filler material is selected from at least one of: sodium carbonate, sodium bicarbonate, potassium carbonate, calcium carbonate, dicalcium phosphate, sodium dihydrogen phosphate.

In some embodiments, based on the total mass of the raw materials, the mass percentage of the filler material is 0.03%-23%, preferably 0.03%-20%, more preferably 0.03%-15%, further preferably 0.03% ~10%, more preferably 0.5% to 10%, still more preferably 1% to 10%, still more preferably 1.5% to 10%, still more preferably 2% to 8%, still more preferably 2% to 6%.

In some embodiments, the feedstock further includes a flavoring agent.

In some embodiments, the flavoring agent is selected from at least one of the following: mint, spearmint, cinnamon, borneol, essence.

Example 1:

The chewing gum was prepared according to the following formula: gum base 54wt%, powdered sugar 23wt%, glucose syrup 14wt%, potassium carbonate 4wt%, mint flavoring agent 3wt%, menthol 1wt%, benzoic acid 0.5%, arecoline 0.5%.

Preparation method: heat the gum base to 70-105°C, put it into a mixer and stir, add powdered sugar, and let the temperature drop to 60-80°C, then add buffer pair, additives, glucose syrup, benzoic acid and arecoline, and finally Rolled and formed into finished products.

Example 2:

Prepare xylitol chewing gum according to the following formula: gum base 54wt%, xylitol 23wt%, non-sucrose 14wt%, potassium carbonate 4wt%, mint flavor 3wt%, menthol 1wt%, benzoic acid 0.5%, arecoline 0.5% .

Preparation method: heat the gum base to 70-105°C, put it into a mixer and stir, add xylitol and non-sucrose, and let the temperature drop to 60-80°C, then add buffer pair, additives, benzoic acid and arecoline, and finally. Rolled and formed into finished products.

Eating and sensory quality evaluation of the chewing gum prepared by the above preparation method and ordinary chewing gum: the chewing gum prepared by the above preparation method can produce a similar effect of chewing betel nut, with low irritation and better taste. Since the chewing gum does not contain lime powder and cellulose, the problems of abrasion and irritation of the oral mucosa and inducing oral diseases that exist when chewing betel nut are avoided.

This written description uses the embodiments to disclose the invention, including the best mode, and also to enable those of ordinary skill in the art to which the invention pertains to make and use the invention. The patentable scope of the invention is defined by the scope of the patent application, and may include other examples that occur to those skilled in the art to which this invention pertains. Such other embodiments do not differ if such other embodiments have structural elements that do not differ from the literal language of the claimed scope, or if such other embodiments include equivalent structural elements with insubstantial differences from the literal languages of the claimed scope Examples are intended to be within the scope of the claimed scope. To the extent that it does not create inconsistency, all citations referenced herein are incorporated herein by reference.

none

Claims (10)

A composition wherein the composition comprises arecoline and an acid. The composition of claim 1, wherein the acid is selected from at least one of the following: formic acid, acetic acid, propionic acid, butyric acid, isovaleric acid, 2-methylbutanoic acid, valeric acid, 3-methylpentanoic acid acid, 2-methyl-2-pentenoic acid, trans-2-hexenoic acid, caproic acid, heptanoic acid, octanoic acid, 2-nonenoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, Octadeic acid, arachidic acid, benzoic acid, salicylic acid, oxalic acid, citric acid, sorbic acid, tartaric acid, adipic acid, hydrochloric acid, hydrobromic acid, glycine, alanine, valine, leucine, iso Leucine, methionine (methionine), phenylalanine, proline, tryptophan, serine, tyrosine, cysteine, methionine, aspartamine, glutamine Amine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine. The composition according to any one of claims 1 to 2, wherein the molar ratio of the arecoline to the acid is n; wherein, the value range of the n is 0<n≦10, preferably 0<n≦8, more preferably 0<n≦6, still more preferably 0<n≦5, still more preferably 0<n≦3, still more preferably 0<n≦2. The composition of any one of claims 1 to 3, wherein the arecoline and the acid form an arecoline salt. A betel nut-flavored product, wherein the product comprises the composition of any one of claims 1 to 4. The article of manufacture of claim 5, wherein the article is an aerosol-forming substrate for being nebulized to generate an aerosol for ingestion. The product according to claim 6, wherein the aerosol-forming substrate is a liquid phase, and is used for any one of a heating atomization device, an ultrasonic atomization device, an air-compressed atomization device, and a press-type atomization device. Nebulized to generate an aerosol. The article of claim 6, wherein the aerosol-generating substrate is a solid phase configured to generate an aerosol for inhalation when heated below the ignition point. The article of claim 5, wherein the article is a bead for use in an aerosol-generating article. The article of manufacture of claim 5, wherein the article is chewing gum.