TW202211915A - Olfactory enrichment composition for soothing and calming the pets - Google Patents

Abstract

The invention relates to an olfactory enrichment composition for soothing and calming the pets, which contains at least two terpenoids compound. The terpenoids includes a first active ingredient sourced from iridoid-like structure compounds, and a second ingredient sourced from linear monoterpenoid or hemiterpenoid compounds. The weight percentage of the first active ingredient in the composition ranges from 0.01% to 3%; and the weight percentage of the second active ingredient in the composition ranges from 0.01% to 3%.

Description

Composition for soothing and calming pets by smell

The present invention relates to a composition for soothing and calming pets by enriching the olfactory senses of pets after being smelled by pets.

Nowadays, pets or companion animals are closely related to many people's lives, and changes in the environment can easily cause pressure and urgency for pets. For example, environmental changes, new pets, changing owners, noise and even weather changes may be sources of stress for pets , causing problem behavior in pets.

When pets face stress or stress, the behavior of their response is mainly dominated by the nervous system and endocrine system. More specifically, the pet's defensive behavior may be accompanied by changes in blood constancy. For example, stress often prompts the pet to release adrenocorticotropic hormone (ACTH), which in turn affects the adrenal gland's secretion of cortisol, resulting in abnormal pet behavior and growth. Growth retardation, disease occurrence, and even life-threatening in severe cases. On the other hand, in the case of pet groups, stressful behaviors often lead to aggressive fights between pets. Taking domestic cats as an example, when cats are in a state of stress, certain stressful behaviors, such as scratching their paws and abnormal defecation, often appear. In addition to threatening the pet’s health, these problematic behaviors may also bring health problems to the owners. Therefore, how to properly relieve the pressure of pets has become a common demand of pet owners.

In response to the above needs, a common approach today is to improve pet stress through environmental enrichment. The so-called environmental enrichment generally refers to any method of improving pet health by adjusting the environment, which essentially covers all the diverse environmental conditions accessible to pets' senses such as vision, hearing, temperature, smell, touch, etc., thereby improving pet behavior and improving pet behavior. The ability of pets to adapt to stressful and distressing situations.

For the physiological mechanism of pets, smell is an important sensory pathway. For example, the olfactory organs of the most common pet dogs and cats have a developed vomeronasal organ (VNO), which is responsible for capturing chemical information molecules in the environment. It is an indispensable part of the innate vigilance, defense, foraging, reproduction and other functions of pets. There are specific neuroreceptors distributed in the nose hoe. When a specific chemical message molecule binds to a specific receptor, it can initiate the transmission of nerve signals to the brain, and then the nerve signals are sent from the brain area to cause specific behavioral responses. Therefore, it is feasible to soothe and relieve the stress, anxiety, and urgency of the pet through the pet's olfactory pathway, so as to calm the pet and improve the behavior. To sum up, the previous cases are listed to further illustrate the development overview of this technical field.

U.S. Patent Publication No. US5709863 discloses a composition for preventing domestic cats from arbitrarily defecation and marking, which contains oleic acid (oleic acid), azelaic acid (azelaic acid), pimelic acid (pimelic acid), Palmitic acid and other ingredients, but limited by the low vapor pressure of fatty acids and poor water solubility, it is difficult to dissolve in the physiological environment, so it is difficult to exert the effect of stimulating VNO and activating receptors, so the above-mentioned active ingredients are contained in the composition. The concentration must be increased to more than 10% by weight.

US Published Patent Application No. US2011/0150822A1 discloses a composition in which squalene, linoleic acid and 1-docosanol are used as a pet olfactory enrichment formula , but still limited by the limitation of fatty acids, the concentration and amount of these components must be significantly increased to activate the target receptors.

European Patent Application for Invention Publication No. EP2954886A1 discloses an esterified fatty acid, which is used to solve the problem of free fatty acid diffusion and the limitation of high concentration, and claims that it can use less than 1% by weight of esterified fatty acid to generate and high concentration free fatty acid. fatty acid similar enrichment effect. However, esterified fatty acids still have the problems of low vapor pressure and poor water solubility, which still limit the activation effect of the receptor on VPO, so it is still difficult to exert its function.

International Patent Cooperation Treaty (PCT) application published patent No. WO2013/043879Al discloses a pheromone-like molecule (interomone) derived from the mammary gland of female rabbits, named "2-methyl-2-butenal" (2- methylbut-2-enal), used in various compositions as a chemical signaling molecule for cross-species communication to modulate vertebrate behavior. However, there is a lack of evidence in the disclosure that this composition has an olfactory enriching effect.

On the other hand, among pet smell enrichment methods, aromatherapy is gradually gaining importance, such as essential oils. For example, essential oils derived from plants such as basil, valerian, clary sage, vetiver, rosemary, etc. have been shown to be effective in both humans and pets It has the effect of calming emotions and relieving stress, and there are many related products on the market. However, due to physiological differences between humans and pets, some of the aforementioned essential oils have specific compounds that are toxic to pets, such as benzene rings, benzyl alcohol, pinene, and terpineol (terpineol), cineole (cineole), (camphor), phenols (phenols), limonene (limonene) and cyclic monoterpene alcohol (cyclic monoterpene), even the competent authority has warned that some essential oils may be harmful to pets cause harm.

In view of the above-mentioned situations and needs, how to achieve effective soothing, calming, soothing and calming effects through appropriate chemical signal molecules through the pet's olfactory pathway has become a common need for pet owners to be met.

According to the above object, the present invention proposes a composition for soothing and calming pets through application by the sense of smell of pets, which comprises at least two terpenoids, wherein one of the two terpenoids has an iridoid-like structure the first active ingredient, and the other is the second active ingredient having a linear structure monoterpene or semiterpene; in this composition, the weight percentage of the first active ingredient ranges from 0.01% to 3%, the second active ingredient The weight percentage ranges from 0.01% to 3%.

According to the above purpose, according to a preferred embodiment of the present invention, in the aforementioned composition, the weight percentage of the first active ingredient ranges from 0.05% to 1%, and the weight percentage of the second active ingredient ranges from 0.05% to 1%. %.

According to the above purpose, according to a preferred embodiment of the present invention, in the aforementioned composition, the first active ingredient is selected from the group consisting of dihydroactinidiolide, nepetalactone, 2,3-cyclolactone 2,3-cyclopentenopyridine, nepetalic acid, valerenic acid, dihydronepetalactone, actinidine, dolicholactone and mixtures thereof formed groups.

According to the above purpose, according to a preferred embodiment of the present invention, in the aforementioned composition, the second active ingredient is selected from neryl acetate, linalyl acetate, vetiver acetate (vetiver acetate), linalool (linalool), citral (citral), nerol (nerol), geranyl acetate (geranyl acetate), angelic acid (angelic acid), isovaleric acid (isovaleric acid), glycerol A group consisting of tiglic acid and mixtures thereof.

According to the above purpose, according to a preferred embodiment of the present invention, it further comprises a solvent, and in the composition, the weight percentage of the solvent ranges from 50% to 99%.

According to the above purpose, according to a preferred embodiment of the present invention, it further comprises a co-solvent, and in the composition, the weight percentage of the co-solvent ranges from 3% to 20%.

According to the above purpose, according to a preferred embodiment of the present invention, it further comprises an antioxidant. In the composition, the weight percentage of the antioxidant ranges from 0.001% to 3%.

According to the above purpose, according to a preferred embodiment of the present invention, it further comprises an antimicrobial agent, and in the composition, the weight percentage of the antimicrobial agent ranges from 0.01% to 5%.

In order to make the purpose, technical features and advantages of the present invention more understandable to those in the relevant technical field and to implement the present invention, the technical features and embodiments of the present invention are specifically explained here in conjunction with the accompanying drawings, and listed The preferred embodiment is further described. The drawings contrasted in the following text are schematic representations related to the features of the present invention, and do not and do not need to be completely drawn according to the actual situation. And the technical contents that are well-known to those skilled in the art related to the embodiments are not described again.

Aiming at the needs of pets soothing and calming, the present invention discloses a composition, wherein active ingredients are combined with its solvent, co-solvent, antioxidants, antimicrobials and other ingredients to achieve the effect of relieving pet's emotions and stress. Compared with the prior art, the required active ingredient concentration of the composition proposed by the present invention is lower, and under the condition of lower concentration, the pet can smell the pet to achieve the pet's soothing effect.

More specifically, the present invention discloses a composition for soothing and calming pets through smell, the main active ingredient of which comprises at least two terpenoids, wherein one of the two terpenoids is a cycloalkene The first active ingredient is an iridoid-like structure, and the other is a second active ingredient having a linear monoterpenoid or hemiterpenoid. Among the ingredients contained in the composition, the weight percentage of the first active ingredient in the composition ranges from 0.01% to 3%, and the weight percentage of the second active ingredient ranges from 0.01% to 3%.

According to a preferred embodiment of the present invention, in the composition proposed by the present invention, the weight percentage of the first active ingredient ranges from 0.05% to 1%, and the weight percentage of the second active ingredient ranges from 0.05% to 1%. .

According to a preferred embodiment of the present invention, in the composition proposed by the present invention, the first active ingredient is selected from dihydroactinidiolide, nepetalactone, 2,3-cyclopentane Compounds such as 2,3-cyclopentenopyridine, nepetalic acid, valerenic acid, dihydronepetalactone, actinidine, dolicholactone, and The group consisting of mixtures of the foregoing compounds.

According to a preferred embodiment of the present invention, in the composition proposed by the present invention, the second active ingredient is selected from neryl acetate, linalyl acetate, vetiver acetate ( vetiver acetate, linalool, citral, nerol, geranyl acetate, angelic acid, isovaleric acid, chamomile flower Compounds such as tiglic acid, and the group consisting of mixtures of the foregoing.

According to a preferred embodiment of the present invention, the composition of the present invention further comprises a solvent, and its weight percentage is generally in the range of 50% to 99%; but in the implementation of the present invention, its weight percentage is in the range of 70% The effect is better when it reaches 90%. As for the type of solvent, it depends on the selection of the first active ingredient and the second active ingredient. The principle of selection is that the solvent must be able to easily dissolve the first active ingredient and the second active ingredient, so as to achieve the aforementioned first active ingredient and The weight percent concentration of the second active ingredient is not substantially limited in the present invention. However, the composition according to the present invention is designed to be administered through the olfactory route of pets. Therefore, considering the absorption effect of the pet nose hoe, the ideal solvent should have good water solubility or polarity, and be suitable for spray and spray application. method and apparatus. Based on the foregoing considerations, the present invention proposes that specific options for the solvent contained in the composition include, but are not limited to, ethanol, isopropanol (IPA), n-propanol (n-propanol), butanol (butaonl), and mixtures of the foregoing solvents formed groups.

Based on the fact that the composition proposed by the present invention must rely on the active ingredients contained in it to exert its effect, the composition of the present invention may further comprise a cosolvent, whose weight percentage is generally in the range of 3% to 20%; When invented, it is more effective when its weight percentage ranges from 5% to 15%. As for the types of co-solvents, it depends on the selection of the first active ingredient and the second active ingredient. The principle of selection is that the co-solvent must be able to sufficiently prolong the loading of the first active ingredient and the second active ingredient in the composition at room temperature. time, and promote the effect of spray/spray application, so the present invention is not limited in essence. However, as the compositions according to the present invention are designed to be administered by the pet olfactory route, ideal co-solvents need to have lower vapor pressure properties (relative to the solvent) and not be toxic to specific species of pets. In light of the foregoing considerations, the present invention proposes that specific options for the co-solvent contained in the composition include, but are not limited to, glycol compounds, however, for practical applications, ethylene glycol, propylene glycol, Toxic concerns for pets, so ideal co-solvent options are relatively long chain diethylene glycol, dipropylene glycol, triethylene glycol, tripropylene glycol (tripropylene glycol), diethylene glycol ethyl ether (ethyl carbitol), diethylene glycol butyl ether (butyl carbitol), and the group consisting of mixtures of the foregoing co-solvents.

Based on the preservation of the active ingredients contained in the composition proposed by the present invention, the composition of the present invention may further comprise an antioxidant (antioixdant), whose weight percentage is generally in the range of 0.001% to 3%; but in the implementation of the present invention, its weight percentage A range of 0.01% to 1% is ideal. As for the types of antioxidants, there is no restriction, and the main thing is that they do not affect the efficacy of active ingredients and are safe. Specific options include but are not limited to dibutylhydroxytoluene (BHT), butylhydroxymethoxybenzene (BHA), and the aforementioned antioxidants. A group consisting of mixtures of oxidizing agents.

Based on the preservation of the active ingredients contained in the composition of the present invention, the composition of the present invention may further comprise an antimicrobial agent, the weight percentage of which is generally in the range of 0.01% to 5%; but in the implementation of the present invention, its The effect is ideal when the weight percentage ranges from 0.05% to 1%. As for the selection of types, in accordance with the characteristics of the active ingredients, formulations, dosage forms, etc. of the composition of the present invention, the ideal antimicrobial agent is short-chain fatty acids, and specific options include but are not limited to acetic acid (acetic acid), propanoic acid (propanoic acid) acid), lactic acid, pyruvic acid, succinic acid, butyric acid and valeric acid.

Since the composition proposed in the present invention is applied by pet's sense of smell, the preferred embodiment is to prepare it as a spray and use it as a spray, for example, it is used with a spray bottle, a spray device, and a heating device. The scope of application is mainly based on where the pet is located. It can also be applied locally to places where pets have problem behaviors. If domestic cats are used as an example, the composition can be diffused in the air of the place where pets are located through a heating device and a sprayer, and it can also be applied locally by spraying.

In order to further illustrate the embodiments and effects of the composition proposed by the present invention, the following examples are given to illustrate.

Example 1

According to the composition proposed by the present invention, three formulas are listed: A formula, B formula, and C formula are exemplified, and the solvent and co-solvent that do not contain active ingredients are used as control formulas, a total of four groups of formulas, and their specific components are as follows. Show. Element Recipe (w/w)% A formula B formula C formula Control formula Dihydrokiwifruit lactone 0.7% - - - nepetalactone - 0.4% - - 2,3-Cyclopentenepyridine - - 0.5% - neryl acetate 0.7% - - - Agaryl acetate - 0.8% - - Vetiver acetate - - 0.7% - BHT 0.3% 0.3% 0.3% - isopropyl alcohol 67.3% - - 70% Ethanol - 67.7% - - Butanol - - 67.5% - glycerin 30% - - 30% Dipropylene glycol - 30% - - Tris[extensive]ethylene glycol - - 30% - acetic acid 1.0% - - - propionic acid - 0.8% - - Lactic acid - - 1.0% - total 100% 100% 100% 100%

Example 2

Topical Application to Equipment: Evaluation of the effect of spraying the compositions of the present invention with a sprayer on specific equipment on modulating the behavior of domestic cats.

The experiment of this example was conducted after the consent of the domestic cat owners, and the behavior of the domestic cat scratching its claws was used as the observation index. First, the two groups of cat scratching boards were sprayed with formula A and the control formula respectively for treatment, and then the two groups of cat scratching boards treated with different sprays were placed adjacent to each other in a closed room. Next, 21 domestic cats (11 male cats and 10 female cats) ranging in age from 11 months to 7 years old were brought into this room and observed for 2 hours. The number of times the cat scratches the two groups of cat scratching boards. The recorded results showed that the total number of times of 21 domestic cat scratch pads sprayed with the control formula was 41; The total number of times is only 3 times. Statistical analysis of this test data showed that the difference in scratching and grinding between the two groups (formula A and control formula) was statistically significant, that is, the treatment and application of formula A could significantly reduce the scratching and grinding behavior of domestic cats.

Example 3

Environmental Spray Application: The effect of spraying a composition of the present invention into the environment on domestic cat behavior was assessed.

The experiment of this example was conducted with the consent of domestic cat owners, and 63 domestic cats with one or more of the following behaviors were recruited to participate in the experiment: abnormal defecation (random urination), scratching, aggression, depression, loss of appetite, pacing Step, yell. The aforementioned 63 domestic cats with problematic behavior were equally divided into 3 groups for the following experiments:

Group A: The test subjects were 21 domestic cats not administered any composition, and the owners were asked to continuously observe the behavior of the aforementioned domestic cats within one week.

Group B: The test subjects were 21 domestic cats with the aforementioned problem behaviors. The cats were exposed to the control formula spray (the dose of 2 ml of the composition was applied within 8 hours per day) for one week. The owners continued to observe the behavior of the cats over the course of a week.

Group C: The test subjects were 21 domestic cats with the aforementioned problem behaviors, and the cats were exposed to the spray of formula B (the dose was 2 ml of the composition within 8 hours per day) for one week. During this period, please The owners continued to observe the behavior of the cats over the course of a week.

The trial was blinded, ie the owners of the domestic cats did not know which composition was used during the trial. When evaluating the effect, the owner was simply asked if he noticed the improvement in the cat's behavior during the one-week trial period. The owner only had to answer "yes" or "no".

  Group A Group B Group C Yes 2 1 18 no 19 20 3 improvement rate 9.50% 4.70% 85.70%

The results listed in the table above show that in the group (group B) sprayed with the composition of the present invention, the vast majority of owners noticed a significant improvement in the behavior of domestic cats.

It can be seen from the above examples that in terms of the concentration of active ingredients, the composition proposed by the present invention is significantly lower than the concentration of active molecules used in the prior art by 10 times. Achieving the effect of soothing and calming pets is sufficient to demonstrate the effect of the present invention. In addition, since the active ingredients in the composition formula proposed by the present invention are simple, safe, and have low active concentration (the expected effect can be achieved under low concentration conditions), it also achieves the reduction of product manufacturing costs, thereby enhancing additional benefits.

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Claims (8)

A composition for soothing and calming pets through smell, comprising at least two terpenoids, wherein one of the two terpenoids is a first active ingredient having an iridoid-like structure, and the other It is a second active ingredient with a linear structure of monoterpene or semiterpenoid. In the composition, the weight percentage of the first active ingredient ranges from 0.01% to 3%, and the weight percentage of the second active ingredient ranges from 0.01%. % to 3%. The composition of claim 1, wherein in the composition, the weight percentage of the first active ingredient ranges from 0.05% to 1%, and the weight percentage of the second active ingredient ranges from 0.05% to 1%. . The composition of claim 1, wherein the first active ingredient is selected from dihydroactinidiolide, nepetalactone, 2,3-cyclopentenopyridine ), nepetalic acid, valerenic acid, dihydronepetalactone, actinidine, dolicholactone and mixtures thereof. The composition of claim 1, wherein the second active ingredient is selected from neryl acetate, linalyl acetate, vetiver acetate, linalool ( linalool, citral, nerol, geranyl acetate, angelic acid, isovaleric acid, tiglic acid and mixtures thereof formed groups. The composition of claim 1, further comprising a solvent, and in the composition, the weight percentage of the solvent ranges from 50% to 99%. The composition of claim 1, further comprising a co-solvent, and in the composition, the weight percentage of the co-solvent ranges from 3% to 20%. The composition of claim 1, further comprising an antioxidant, and in the composition, the weight percentage of the antioxidant ranges from 0.001% to 3%. The composition of claim 1, further comprising an antimicrobial agent, and in the composition, the weight percentage of the antimicrobial agent ranges from 0.01% to 5%.