TW202211797A - Dinotefuran oil suspension, use and method for preparing same - Google Patents

Abstract

The invention provides a dinotefuran oil suspension, use and method for preparing the same. Except dinotefuran active substance, the oil suspension also contains at least one synergist of fatty alcohol ethoxylated propoxylate with the general formula RO-(EO)x-(PO)y-OH; wherein R is a C8~C20 alkyl group, EO is an ethyleneoxy group, PO is a propyleneoxy group, x is an integer from 1 to 20, and y is an integer from 1 to 20; the oil suspension containing dinotefuran active substance and the synergist prepared by in present invention greatly improves the insecticidal activity of dinotefuran, reduces the amount of active substance, and reduces the impact on the environment. The spray liquid containing the oil suspension agent has excellent physical and chemical properties without obvious emulsion layering. When it is used in plants and/or plant growth environment, it can enhance the penetration of the oil suspension agent at the application site and improve the application efficiency.

Description

DINOTEFURAN oil suspension agent, its use and preparation method

The invention relates to the field of pesticides, in particular to a Dartnam oil suspension agent and a preparation method and application thereof.

Dartnam, the third-generation nicotinic insecticide developed by Japan's Mitsui Chemicals, has a broad spectrum of insecticides and is a stimulant of nicotinic acetylcholine receptors, which affects the processes of insect central nervous system through spinal nerve transmission. Contact, with contact and stomach poisoning and excellent systemic penetration. Dartnam is very safe to mammals, birds and aquatic organisms, and has no phytotoxicity to crops. It can control various pests of Hemiptera, Lepidoptera, Coleoptera, Diptera, Hymenoptera, etc. It has a high control effect against lice, lichen striatellus, and night tail cicadas.

Although datnam has a strong control effect on various pests, datnam belongs to a class of insoluble active ingredients, the solubility in water at 25 ° C is only 40g/L, and the solubility in other medium and low polar solvents is not very high. Therefore, for Dartnam's poorly soluble active ingredient or the combination of Dartnam's poorly soluble active ingredient and other agricultural chemicals, it is generally selected to be prepared as a dispersible oil suspension agent to improve the utilization rate of the active substance, so as to achieve a synergistic effect. Among them, the dispersible oil suspension agent is a highly dispersed stable suspension system with a non-aqueous system as the dispersion medium, and is a formulation that uses a class of tested oils that can be used as synergists and does not pollute crops as a dilution carrier. Including vegetable oil and its derivatives or mineral oil, etc.

CN106359440A discloses Dartnam dispersible oil suspension agent, wherein the content of each component is: Dartnam 20-30%, octylphenol polyoxyethylene ether 4-6%, calcium dodecylbenzenesulfonate 4-6% %, phenethyl phenyl propyl phenol polyoxyethylene ether 4~6%, organic bentonite 0.8~1.2%, silica 0.8~1.2%, citric acid 0.1~0.5%, dihydrogenated tallow phthalamide 0.1~0.5%, Tris(2,4-di-tert-butylphenyl) phosphite 0.1~0.5%, 2-n-octyl-4-isothiazolin-3-one 0.1~0.5%, HT-508 organosilicon 0.1~0.5%, soybean oil 18~22%, and the balance is methyl oleate; this oil suspending agent solves the problems of oil separation, stratification, caking, high decomposition rate and chemical instability in Dartnam preparations. However, the control effect of the oil suspension agent on pests is still low, and it is difficult to give full play to the activity of Dartnam.

CN109169646A discloses a preparation method of datnam oil suspending agent, in order to solve the technical problems such as large particle size and low efficacy of datnam in the preparation obtained by the existing preparation process, causing mechanical impurities and the like, but the preparation method controls the milk by stirring The diameter of the droplets is low, the repetition rate of this method is low, and it is difficult to produce on a large scale.

CN101784184B discloses a compound with structural formula RO-(EO) _w- (PO) _x- (EO) _y (PO) _x -H as a synergist for neonicotinoid compounds, specifically acetamiprid, and in particular The composition under the condition of solvent combination has a certain effect of increasing the control effect, but the synergistic effect is still low.

To sum up, although the oil suspension containing Dartnam in the prior art has a synergistic effect than other formulations of Dartnam, it is still not very ideal. Therefore, it is very necessary to find a synergist suitable for the use of datnam oil suspending agent and further improve the activity of datnam.

In order to solve the technical problem of the synergistic effect of the datnam-containing suspending agent, the present invention finally found a stable and efficient datnam-containing oil suspending agent composition through numerous formulation experiments and bioassays. The substance is physicochemically stable, and especially has a particularly good insecticidal control effect.

To achieve this purpose, the present invention adopts the following technical solutions: In a first aspect, the present invention provides a Dartnam oil suspending agent, and the oil suspending agent includes the following components: Component A: Dart which is solid at room temperature South active substance; B component: at least one synergist of fatty alcohol ethoxylated propoxylate with general formula RO-(EO) _x- (PO) _y -OH, wherein R is C8~C20 Alkyl, EO is ethylideneoxy, PO is propylideneoxy, x is an integer of 1~20, y is an integer of 1~20; C component: nonionic surfactant and/or anionic surfactant agent; D component: any one or a combination of at least two of vegetable oil, vegetable oil ester or aromatic hydrocarbon solvent.

In the present invention, the synergist of the general structure in the B component, a typical but non-limiting example is C8~C20 (for example, it can be C8, C9, C10, C11, C12, C13, C14, C15, C16, C18, C19 or C20) alkyl monohydric alcohol with 1~20 (for example, it can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 , 16, 18, 20) units of ethylideneoxy and 1~20 (for example, can be 1, 2, 3, 4, 5, 7, 8, 10, 12, 15, 16, 17, 18, 20 ) units of propylideneoxy block copolymerization to form an ester, such as C8H17-O-EO-PO-OH, _{C9H19 -} O-(EO) _2- (PO) ₃ -OH, _C11H23 -O-(EO) _4- (PO) ₅ -OH, _C13H27 -O-(EO) _5- (PO) ₇ -OH, _C14H29 - _O- (EO) _8- ( _PO ) ₈ -OH , C ₁₅ H ₃₁ -O-(EO) ₁₁ -(PO) ₁₃ -OH , C ₁₅ H ₃₁ -O-(EO) ₁₄ -(PO) ₁₃ -OH , C ₁₆ H ₃₃ -O-(EO ) ₁₉ -(PO) ₁₇ -OH or C ₁₆ H ₃₃ -O-(EO) ₂₀ -(PO) ₂₀ -OH, the monohydric alcohol of the C8~C20 alkyl group can be octanol, decanol, dodecane alcohol, tetradecanol, hexadecanol, heptadecanol, octadecanol or eicosanol.

In the present invention, by selecting fatty alcohol ethoxylated propoxylate with the general formula RO-(EO) _x- (PO) _y -OH as the synergist, the synergist can easily adhere to the plant surface and It has a certain dissolving effect on the waxy layer of plants, and enhances the absorption of droplet active substances by the stomata and cuticle of the plant epidermis, so that the oil suspension agent can effectively improve the activity of Dartnam, and significantly improve the oil suspension agent containing Dartnam. Insecticidal effect, reducing the use of Dartnam and reducing the impact on the environment.

As a preferred technical solution of the present invention, R in the general formula RO-(EO) _x- (PO) _y -OH of the B component is a C8-C14 alkyl group.

Preferably, in the general formula RO-(EO) _x- (PO) _y -OH, x is an integer of 2-16.

Preferably, y in the general formula RO-(EO) _x- (PO) _y -OH is an integer of 2-16.

Preferably, the nonionic surfactant is ethylene oxide-propylene oxide block copolymer, fatty alcohol polyoxyethylene ether, the polymerization reaction product of fatty alcohol and ethylene oxide and/or propylene oxide, Copolymers of methacrylic acid and methacrylate, alkyl glycosides, polyvinyl alcohol, polyvinyl pyrrolidone, alkyl ethoxylates, alkylaryl ethoxylates or the Tween series (polyoxyethylene sorbitan Monolaurate and a part of the mixture of polyoxyethylene bissorbitan monolaurate) any one or a combination of at least two, wherein typical but non-limiting combinations are: fatty alcohol polyoxyethylene ether and alkane Combinations of alkyl glycosides, combinations of polyvinyl alcohol and alkyl glycosides, combinations of polyvinyl pyrrolidone and alkyl ethoxylates, combinations of alkyl ethoxylates and alkyl glycosides, alkyl aryl ethoxylates and cyclic Combination of ethylene oxide-propylene oxide block copolymer, combination of ethylene oxide-propylene oxide block copolymer and alkyl glycoside, combination of fatty alcohol polyoxyethylene ether and polyvinylpyrrolidone, fatty alcohol polyoxyethylene A combination of vinyl ether and polyvinyl alcohol.

Preferably, the anionic surfactant is selected from lignosulfonate (Borresperse NA), succinate sulfonate, naphthalene sulfonate formaldehyde polycondensate, sulfate of tristyrylphenyl ethoxylate, Any one or a combination of at least two of the phosphates or polycarboxylates of tristyrene ethoxylates, wherein typical but non-limiting combinations are: a combination of lignosulfonate and succinate sulfonate, naphthalene Combination of sulfonate formaldehyde polycondensate and succinate sulfonate, combination of lignosulfonate and naphthalene sulfonate formaldehyde polycondensate, sulfate and succinate sulfonate of tristyrylphenyl ethoxylate A combination of tristyrylphenyl ethoxylate sulfate and polycarboxylate, a combination of lignosulfonate and polycarboxylate.

Preferably, the vegetable oil is selected from any one or a combination of at least two of soybean oil, corn oil, rapeseed oil, sunflower oil or peanut oil, wherein a typical but non-limiting combination is: soybean oil and corn oil. Combination, Combination of soybean oil and sunflower oil, Combination of rapeseed oil and corn oil, Combination of rapeseed oil and sunflower oil, Combination of peanut oil and corn oil, Combination of soybean oil and peanut oil.

Preferably, the vegetable oil ester is selected from methyl oleate, epoxidized soybean oil, ethyl laurate, methyl palmitate or methyl linoleate, etc. any one or a combination of at least two, wherein typical but not The limiting combinations are: methyl oleate and epoxidized soybean oil, methyl oleate and ethyl laurate, methyl palmitate and ethyl laurate, ethyl laurate and epoxidized Combination of soybean oil, combination of methyl palmitate and epoxidized soybean oil, combination of methyl linoleate and epoxidized soybean oil, combination of methyl oleate and methyl linoleate.

Preferably, the aromatic hydrocarbon solvent is selected from any one or at least two compositions of light aromatic hydrocarbon solvent, heavy aromatic hydrocarbon solvent, toluene, xylene, mixed trimethylbenzene, Solvesso100, Solvesso150, Solvesso200 or Solvesso200-ND, etc. Non-limiting combinations are: a combination of toluene and xylene, a combination of toluene and mesitylene, a combination of toluene and Solvesso 100, a combination of xylene and mesitylene, a combination of mesitylene and Solvesso 100, and a combination of mesitylene and Solvesso 150 A combination of Solvesso100 and Solvesso150, a combination of Solvesso200 and Solvesso150, a combination of Solvesso100 and Solvesso200-ND.

As a preferred technical solution of the present invention, the oil suspension agent further comprises component E: an additive.

Preferably, the additive is any one or a combination of at least two of emulsifiers, defoaming agents, preservatives, antioxidants, colorants or inert fillers, wherein typical but non-limiting combinations are: emulsifier and Combination of anti-foaming agent, combination of emulsifier and preservative, combination of anti-foaming agent and preservative, combination of antioxidant and coloring agent, combination of coloring agent and inert filler.

Preferably, the emulsifier is a reactant of alkylphenol with ethylene oxide and/or propylene oxide, ethoxylated nonylphenol, castor oil ethoxylate, polyalkoxylated alcohol mixture (Atlox 4894), alkyl calcium salts, calcium alkyl benzene sulfonates, sorbitan derivatives or polyethylene oxide-sorbitan fatty acid esters, any one or a combination of at least two of them, where typical But non-limiting combinations are: combination of ethoxylated nonylphenol and castor oil ethoxylate, combination of ethoxylated nonylphenol and alkyl calcium salt, ethoxylated nonylphenol Combinations with calcium alkyl benzene sulfonates, combinations of castor oil ethoxylates and calcium alkyl salts, combinations of calcium alkyl benzene sulfonates and sorbitan derivatives, calcium alkyl salts and sorbitan derivatives combination of things.

In the present invention, the type of the defoamer is not particularly limited, and the defoamer that is well known to those skilled in the art and commonly used for this purpose in agrochemical compositions can be used.

Preferably, the defoamer is an organosilicon defoamer, preferably a siloxane defoamer.

In the present invention, the types of the preservatives are also not particularly limited, and the preservatives commonly used for this purpose in agrochemical compositions well known to those skilled in the art can be used.

Preferably, the preservatives are Proxel series and/or Nipacide series preservatives.

In the present invention, the type of the antioxidant is also not particularly limited, and the antioxidant commonly used for this purpose in agrochemical compositions well known to those skilled in the art can be used.

Preferably, the antioxidant is 2,6-di-tert-butyl-4-methylphenol.

In the present invention, the type of the colorant is also not particularly limited, and the colorant commonly used for this purpose in agrochemical compositions well known to those skilled in the art can be used.

Preferably, the colorant is any one or a combination of at least two of titanium dioxide, zinc oxide, blue pigment or lightfast red BBN (PigmentRed BBN), wherein a typical but non-limiting combination is: titanium dioxide and zinc oxide. Combination, combination of bright red BBN and zinc oxide, combination of blue pigment and bright red BBN, combination of blue pigment and titanium dioxide, combination of bright red BBN and titanium dioxide, combination of blue pigment and zinc oxide.

In the present invention, the inert filler is not particularly limited, and the inert filler known to those skilled in the art and commonly used for this purpose in agrochemical compositions but not functioning as a thickener can be used.

Preferably, the inert filler is any one or a combination of at least two of urea, silicate, sulfate or oxide, wherein a typical but non-limiting combination is: a combination of urea and silicate, urea And the combination of sulfate, the combination of sulfate and silicate, the combination of sulfate and oxide, the combination of oxide and urea.

Preferably, the oil suspension agent further comprises F component: other pesticide actives.

In the oil suspension agent containing Dartnam provided by the invention, the insecticidal effect of the oil suspension agent can be further enhanced by adding other pesticide active substances without affecting the stability and insecticidal effect of the Dartnam.

The other pesticide actives described in the present invention can either be dissolved in the system of the oil suspending agent in molecular form, or can be suspended in the system of the oil suspending agent in the form of fine particles. The specific existence mode is related to the properties of the pesticide active substance itself, but it does not affect the suspension of Dartnam in the oil suspension agent system as fine particles, which can further enhance the control effect of the oil suspension agent on pests.

Preferably, the other pesticide actives are insecticides, such as chlorpyrifos, spirotetramat, alanycarb, aldicarb, aminocarb, Bendiocarb, benfuracarb, bufencarb, butocarboxim, fenobucarb, formetanate, isoprocarb, Methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, thiodicarb, bovis profenofos, propaphos, prothiofos, pyridaphenthion, pyridathion, sebufos, sulprofos, butyl ether tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, vamidothion, dimethoate , ethopropos, etrimfos, fenitrothion, fosthiazate, isoxathion, malathion, mecarbam, betaxel beta-cyfluthrin, ethofenprox, bifenthrin, cis-cypermethrin, clocythrin, cyfluthrin, cyhalothrin ), cyphenothrin, deltamethrin, fenpropathrin, fenpyrithrin, fenvalerate, flμmethrin, lambda xylon ( lambda-cyhalothrin), tefluthrin, acetamiprid, clothianidin ), dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam, acetonil ( acetoprole, ethiprole, fipronil, abamectin, avermectin, emamectin, ivermectin, milmetin (milbemectin), milbemycin, chromafenozide, halofenozide, methoxyfenozide, tebufenozide, diflubenzuron, flufen flufenoxuron, hexaflumuron, lufenuron, teflubenzuron, bifenazate or buprofezin, preferably pyrethroid activity such as beta-cyfluthrin, ethofenprox, bifenthrin, cis-cypermethrin, clocythrin, cypermethrin (cyfluthrin), cyhalothrin, cyphenothrin, deltamethrin, fenpropathrin, fenpyrithrin, fenvalerate, fenvalerate (flumethrin), lambda-cyhalothrin (lambda-cyhalothrin) or tefluthrin (tefluthrin).

As the preferred technical scheme of the present invention, the weight percent of each component of the oil suspension agent is: A component is 1~30%, for example, it can be 1%, 2%, 5%, 5.8%, 6%, 8.4%, 9.5%, 13.1%, 15%, 17%, 19.6%, 21.3%, 25% , 27.8%, 29% or 30%, preferably 5~25%. B component is 1~15%, for example, it can be 1%, 2%, 4.5%, 6%, 8.3%, 9%, 10%, 11.6%, 13%, 13.8%, 14.3% or 15%, preferably 2~10%. C component is 1~15%, for example, it can be 1%, 2%, 3%, 4.5%, 6%, 7%, 8%, 8.3%, 10%, 11.6%, 13%, 13.8%, 14.3% or 15%, preferably 2~8%. D component is 30~80%, for example, it can be 30%, 32%, 35%, 37%, 40%, 44%, 45%, 50%, 53%, 55%, 57%, 65%, 70%, 72%, 75%, 76% or 80%, preferably 40-70%. The E component is 0~20%, for example, it can be 0%, 1%, 2%, 5%, 7%, 8.8%, 10%, 11.2%, 13%, 14%, 15%, 16.2%, 17.4% , 18.5%, 19%, 19.6% or 20%, preferably 1~15%. F component is 0~30%, such as 0%, 1%, 2%, 5%, 7%, 8.6%, 10.4%, 12%, 14%, 15%, 16.4%, 17.9%, 19% , 20%, 21%, 23.1%, 25%, 28% or 30%, preferably 5~25%.

The oil suspension agent provided by the present invention can optimize the insecticidal effect of the Dartnam active substance by using a special synergist and the above-mentioned specific amount of each component, effectively improve the biological activity of the Dartnam oil suspension agent, and reduce the The dosage of Dartnam actives can achieve better control effect and reduce the pressure on the environment.

In the second aspect, the present invention provides a preparation method of the Dartnam oil suspending agent according to the first aspect, the preparation method is: the A component, the B component, the C component and the D component, And optional components E and F are stirred and mixed to obtain a mixture, and then the mixture is ground to obtain an oil suspension.

In the preparation method provided by the present invention, the components are mixed with each other in any order, so that the preparation process is simple and the processing cost is reduced.

As a preferred technical solution of the present invention, the grinding temperature is 10-60°C, such as 10°C, 15°C, 20°C, 25°C, 30°C, 35°C, 40°C, 45°C, 50°C, 55℃ or 60℃, preferably 15~45℃.

In the preparation method provided by the invention, the grinding temperature conditions are mild, the energy consumption in the production process is reduced, and the production cost is reduced.

Preferably, the grinding is such that the average particle size of the oil suspension agent is less than 8 μm, such as 0.4 μm, 0.8 μm, 1 μm, 2 μm, 3 μm, 3.4 μm, 5 μm, 6 μm, 7 μm, 7.8 μm or 8 μm , preferably 1 to 3 μm.

In the preparation method provided by the present invention, the oil suspension agent is ground to an average particle size of less than 8 μm,

Under the condition of normal temperature storage and/or hot storage, the oil suspension agent has a uniform system, good fluidity, can be kept stable for a long time, and is convenient for storage and use.

As a third-party manufacturer, the present invention provides a spray liquid comprising the Dartnam oil suspending agent as described in the first aspect.

The oil suspension provided by the present invention can be converted into a homogeneous spray liquid by dilution with water, and the spray liquid can be applied by conventional methods, for example, it can be applied by spraying, injecting, dripping or pouring.

The oil suspension agent of the present invention, when diluted with water, has neither obvious emulsion layering nor destructive flocculation, and has very stable and good physical and chemical properties.

In a fourth aspect, the present invention provides a use of the Dartnam oil suspension formulation as described in the first aspect for plants and/or plant growth environments.

When the oil suspending agent of the present invention is applied to plants, it can be absorbed by the plants in time, enhance the penetration of the oil suspending agent in the plant application site, improve the application efficiency, enhance the bioavailability of the active substance of datnam, reduce its dosage, and alleviate the environment pressure.

In a fifth aspect, the present invention provides the use of the Dartnam oil suspension agent according to the first aspect for controlling insects.

The oil suspension agent of the invention not only has good stability, but also can significantly improve the activity of the active ingredient datnam, and improve the control effect of the oil suspension agent on insects.

Preferably, the insects to be controlled are any one or a combination of at least two of Lepidopteran pests, Diptera pests, Hemipteran pests or Homoptera pests.

Among them, the Lepidoptera pests can be Earias insulana, Pieris rapae Linnaeus, Herpetogramma licarsisalis Walker, Spodopterafugiperda, Fall Armyworm (Spodoptera frugiperda), Inferior (Rachiplusia nu), Pseudoplusia includens, Sesamia inferens, Cnaphalocrocis medinalis Guenee, Maruca testulalis, Cirphisunipuncta, Tomato Tuta absoluta, Trichoplusia ni, Sesamianonagrioides, Trichoplusia ni, Anticarsiagemmatalis, Grapholitha molesta, Potato Tuber moth (Phthorimaeaoperculella), wheat moth (Sitotroga cerealella), cotton bollworm (Earias vittella Fabricius), cotton brown banded moth (Adoxophyes orana), cotton bollworm (Pectinophoragossypiella Saunders), cotton bollworm (Heliothis armigera), cotton Alabama argi llacea, Lymantriamonacha, Cydia pomonella, Pandemis heparana, Lobesia botrana, Spagaranothis pilleriana ), Endopiza vriteana Clemens, Scirpophaga incertulas, Spodopteraexigua Hübner, Spodopteraritura, Ephestiaelutella, Heliothis virescens , Epinotia aporema, Tineolabisselliell a), Indian valley butterfly (Plodia interpunctella) or corn borer (Ostrinianubilalis Hübner); Diptera pests can be Aedes aegypti, Liriomyza brassicae, Sarcophaga haemorrhoidalis, Glossina morsi tans, Phorbiaantiqua, Ceratitis capitata), cabbage fly (Delia radicum), melon fly (Dacuscucurbi tae), horse fly (Tabanus lineola), red head fly (Calliphora vricina), carrot fly (Psila rosae), orange fruit fly (Bactrocera dorsalis), Culicoides furens, Aedes vexans, Rhagoletis mendax, Chrysomya spp., Chrysops discalis, Phorbia brassicae, Si todiplosis mosellana, Liriomyza trifolii, Rhagoletis pomonella, Hippelates, Bactrocera zonata, Pegomya hysocyami, Pegomya betae, Lucilia cuprina or Culexquinquefasciatus; Hemipteran and Homopteran pests can be the white-backed planthopper (Sogatellafurcifera Horvrath), the greenhouse whitefly (Trialeurodes vaporariorum), the blowing scale insect (Ieryapurchasi Maskell), the blowing scale insect (Iceryapurchasi), the soybean aphid (Aphis glycines), Rice planthopper (rice planthopper), rice brown planthopper (Nilaparvata lugens), cabbage aphid (Brevicoryne brassicae), tobacco whitefly (Bemisia tabaci), citrus psyllid (Diaphorina citri), Nephotettix nigropictus, red wax Ceroplastesrubens, Aonidiella aurantii, Laodelphax striatellus, Aphis craccivrora Koch, Macrosiphum avenae, Aphispomi, Psylla mali ), peach aphid (Brachycaudus persicae), green peach aphid (Myzuspersicae Sulzer), pea aphid (Acyrthisiphon pisum Harris), greenhouse whitefly (Trialeurodesvaporariorum), tobacco whitefly (Bemisia tabaci Gennadius), leafhopper (Empoasca spp.), corn Flower-winged planthopper (Peregrinus maidis), corn wax cicada (Peregrinus maidisAshmead), corn aphid (Rhopalosiphum maidis) or vertical rice planthopper (Sogatodes orizicola Muir); Typical but non-limiting combinations are: the combination of Peregrinus maidis Ashmead and Ieryapurchasi Maskell, the combination of Rhagoletis pomonella and Epinotia aporema, the grape leaf roller (Sparganothis pilleriana) and pear worm (Grapholitha molesta), Spodoptera frugiperda (Sesamia inferens) and cabbage white butterfly (Pieris rapae Linnaeus), Sogatodes orizicola Muir and Tobacco budworm ( Combination of Heliothisvirescens, Liriomyza brassicae and Horsefly (Tabanus lineola), Phorbia brassicae and Calligraphy (Chrysomya spp.), Lucilia cuprina and Tobacco bud A combination of the noctuid moth (Heliothis virescens).

Preferably, the oil suspension agent is suitable for preventing and controlling tobacco whitefly, brown planthopper, aphids, scale insects, thrips, rice leaf rollers, trichillalis, red spider, Spodoptera litura, cabbage caterpillars, diamondback moth, sugar beet. Spodoptera frugiperda, yellow-striped flea beetle or green leafhopper, preferably for the control of brown planthopper and/or Spodoptera litura.

Compared with the prior art, the present invention at least has the following beneficial effects: (1) Compared with the existing oil suspending agent, the oil suspension agent provided by the present invention further improves the insecticidal activity of Dartnam, and the control effect of the three-day application is increased to more than 93%, which makes the insecticidal activity of Dartnam more effective. The ability has been further optimized to reduce the use of Dartnam actives and reduce the impact on the environment; (2) The synergist used in the oil suspension agent provided by the present invention does not affect the conventional physical and chemical properties of the oil suspension agent, and still exhibits excellent stability, and is especially suitable for the stability of preparations containing datnam actives; (3) The oil suspension agent provided by the present invention has neither obvious emulsion layering nor destructive flocculation when the oil suspension agent is diluted with water, meets the requirements of the CAPIC standard, and has very stable and good physical and chemical properties. nature; (4) The oil suspending agent provided by the present invention significantly improves the activity of the datnam, can meet the needs of insect control, and can also be applied to plants and/or plant growth environments to enhance the penetration of the oil suspending agent at the application site. , improve the application efficiency; (5) The preparation method of the oil suspension agent provided by the present invention is simple, easy to operate, and beneficial to industrialized large-scale production.

In order to facilitate the understanding of the present invention, examples of the present invention are as follows. It should be understood by those skilled in the art that the embodiments are only for helping the understanding of the present invention, and should not be regarded as a specific limitation of the present invention. 1. Synergist

The general formula of the B component synergist in the oil suspension agent of the present invention is a fatty alcohol ethoxylated propoxylate of RO-(EO) _x -(PO) _y -OH, and the following are the specific synergists : Synergist A: wherein R is a straight-chain C10 alkyl group, x is 5, y is 5, and the chemical formula is: C ₁₀ H ₂₁ -O-(EO) ₅ -(PO) ₅ -OH; Synergist B: wherein R is a straight-chain C12 alkyl group, x is 10, y is 5, the chemical formula is: C ₁₂ H ₂₅ -O-(EO) ₁₀ -(PO) ₅ -OH; Synergist C: wherein R is a straight-chain C16 Alkyl, x is 16, y is 8, the chemical formula is: C ₁₆ H ₃₃ -O-(EO) ₁₆ -(PO) ₈ -OH; Synergist D: wherein R is a straight-chain C12 alkyl group, and x is 4 , y is 16, the chemical formula is: C ₁₂ H ₂₅ -O-(EO) ₄ -(PO) ₁₆ -OH; Synergist E: wherein R is a linear C14 alkyl group, x is 2, y is 10, the chemical formula As: _C14H29 - _O- (EO) _2- (PO) ₁₀ -OH. 2. Example

Example 1

This embodiment provides a Dartnam 10% OD oil suspending agent, and the quality content of its components is as follows: Dartnam 10% Synergist A 10% Styryl phenol polyoxyethylene ether 10% Calcium dodecylbenzenesulfonate 4% Polycarboxylate 2% Silicone oil 1% Attapulgite 2% Soybean oil supplement 100%

Preparation method: mixing the above substances in any order under stirring at room temperature, stirring evenly to obtain a suspension, and subjecting the suspension to primary coarse grinding and secondary fine grinding of a sand mill at 40 ° C to obtain the average particle size of the suspended particles 2μm datnam oil suspension.

Example 2

This embodiment provides a Dartnam 5% OD oil suspending agent, and the quality content of its components is as follows: Dartnam 5% Synergist B 5% Lignosulfonate 2% Castor Oil Ethoxylates 8% Calcium dodecylbenzenesulfonate 8% Silicone oil 1% Silica 3% Methyl oleate supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Example 3

This embodiment provides a Dartnam 30% OD oil suspending agent, and the quality content of its components is as follows: Dartnam 30% Synergist C 15% Naphthalene sulfonate formaldehyde polycondensate 5% Acrylic copolymer 3% Sodium dodecylbenzenesulfonate 15% Silicone oil 1% Diatomaceous earth 2% Solvesso 200    Top up 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Example 4

This embodiment provides a Dartnam oil suspending agent of 10% Dartnam and 5% OD of Taos Pine, and the quality content of its components is as follows: Dartnam 10% Taosson 5% Synergist D 8% Lignosulfonate 3% Tristyrylphenyl ethoxylate sulfate 2% Tween 80 8% Calcium dodecylbenzenesulfonate 5% Silicone oil 1% Fumed silica 1.5% Solvesso 150ND 25% Epoxidized soybean oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Example 5

This embodiment provides an oil suspending agent of 8% datnam and 8% OD of etherethrin, and the quality content of its components is as follows: Dartnam 8% Ethermethrin 8% Synergist E 6% Naphthalene sulfonate formaldehyde polycondensate 2% Fatty alcohol ethoxy ether 4% Castor Oil Ethoxylates 10% Calcium dodecylbenzenesulfonate 4% Silicone Oil 1% Silica 2% Solvesso 200ND 30% Corn oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Example 6

This embodiment provides an oil suspension concentrate of 25% datnam and 5% OD of kung fu chrysanthemum, and the quality content of its components is as follows: Dartnam 25% Kung Fu pyrethroid 5% Synergist B 12% Naphthalene sulfonate formaldehyde polycondensate 3% Succinate sulfonate 3% Castor Oil Ethoxylates 10% Tween 20 5% Silicone oil 1% Attapulgite 2% Mixed trimethylbenzene 20% Ethyl Palmitate Make up 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Example 7

The present embodiment provides a kind of oil suspension agent of Dartnam 5% and bifenthrin 25% OD, and the quality content of its components is as follows: Dartnam 5% Bifenthrin 25% Synergist A 8% Lignosulfonate 3% Polycarboxylate 4% Castor Oil Ethoxylates 8% Calcium dodecylbenzenesulfonate 8% Silicone oil 1% Silica 2% Epoxidized soybean oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1. 3. Comparative ratio

Comparative Example 1

This comparative example provides a Dartnam 10% OD oil suspension, the quality content of which is as follows: Dartnam 10% Styryl phenol polyoxyethylene ether 10% Calcium dodecylbenzenesulfonate 4% Polycarboxylate 2% Silicone oil 1% Attapulgite 2% Soybean oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 2

This comparative example provides a Dartnam 5% OD oil suspending agent, and the quality content of its components is as follows: Dartnam 5% Lignosulfonate 2% Castor Oil Ethoxylates 8% Calcium dodecylbenzenesulfonate 8% Silicone oil 1% Silica 3% Methyl oleate supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 3

This comparative example provides a Dartnam 30% OD oil suspension, the quality content of its components is as follows: Dartnam 30% Naphthalene sulfonate formaldehyde polycondensate 5% Acrylic copolymer 3% Sodium dodecylbenzenesulfonate 15% Silicone oil 1% Diatomaceous earth 2% Solvesso 200     Top-up 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 4

This comparative example provides an oil suspension of Dartnam 10% and Taosson 5% OD, the quality content of which is as follows: Dartnam 10% Taosson 5% Lignosulfonate 3% Tristyrylphenyl ethoxylate sulfate 2% Tween 80 8% Calcium dodecylbenzenesulfonate 5% Silicone oil 1% Fumed silica 1.5% Solvesso 150ND 25% Epoxidized soybean oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 5

This comparative example provides an oil suspension of datnam 8% and etherethrin 8% OD, and the quality content of its components is as follows: Dartnam 8% Ethermethrin 8% Naphthalene sulfonate formaldehyde polycondensate 2% Fatty alcohol ethoxy ether 4% Castor Oil Ethoxylates 10% Calcium dodecylbenzenesulfonate 4% Silicone oil 1% Silica 2% Solvesso 200ND 30% Corn oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 6

This comparative example provides an oil suspension of Dartnam 25% and Kungfu 5% OD, and the quality contents of the components are as follows: Dartnam 25% Kung Fu pyrethroid 5% Naphthalene sulfonate formaldehyde polycondensate 3% Succinate sulfonate 3% Castor Oil Ethoxylates 10% Tween 20 5% Silicone oil 1% Attapulgite 2% Mixed trimethylbenzene 20% Ethyl Palmitate Make up 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 7

This comparative example provides an oil suspension of Dartnam 5% and Bifenthrin 25% OD, and the quality contents of the components are as follows: Dartnam 5% Bifenthrin 25% Lignosulfonate 3% Polycarboxylate 4% Castor Oil Ethoxylates 8% Calcium dodecylbenzenesulfonate 8% Silicone oil 1% Silica 2% Epoxidized soybean oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1.

Comparative Example 8

This comparative example utilizes the prior art formula (CN106359440A Example 1) to provide a 20% OD suspending agent for Dartnam oil, and the quality content of its components is as follows: Dartnam 20% Octylphenol polyoxyethylene ether 4% Calcium dodecylbenzenesulfonate 4% Styrene phenyl propyl phenol polyoxyethylene ether 6% Silicone bentonite 0.8% Silica 0.8% Citric acid 0.1% Dihydrogenated tallow phthalamide 0.1% Tris(2,4-di-tert-butylphenyl) phosphite 0.1% 2-n-Octyl-4-isothiazolin-3-one 0.1% HT-508 Silicone 0.1% Soybean Oil 18% Methyl oleate supplement 100%

Preparation method: add octylphenol polyoxyethylene ether, calcium dodecylbenzenesulfonate and phenethyl phenylpropylphenol polyoxyethylene ether to soybean oil and methyl oleate, mix and disperse evenly, and shear at high speed Add Dartnam's original medicine under stirring, add organic bentonite, white carbon black and HT-508 organosilicon, mix, grind to a particle size of about 2μm, add citric acid, dihydrogenated tallow phthalamide, and tris-phosphite. (2,4-di-tert-butylphenyl) ester, 2-n-octyl-4-isothiazolin-3-one, to obtain Dartnam dispersible oil suspension.

Comparative Example 9

This comparative example uses the prior art formula (CN109169646A embodiment 3) to provide a Dartnam 10% OD oil suspension agent, and the quality content of its components is as follows: Dartnam 10% Distilled water 8% Styryl phenol polyoxyethylene ether 10% Alkylbenzene sulfonate 4% Polycarboxylate 2% Attapulgite 2% Soybean oil supplement 100%

Preparation: (1) Mix the Dartnam and the solvent, and heat to 58°C under stirring at 500 rpm, so that the Dartnam is completely dissolved in distilled water; add styryl phenol polyoxyethylene ether and polycarboxylate and continue to stir to obtain Dart. South water agent; (2) Mix alkylbenzene sulfonate, attapulgite and soybean oil, and mechanically stir at 700 rpm until uniform to obtain a mixed oil; (3) With high-speed stirring at 10000rpm, the Dartnam water agent in step (1) was added dropwise to the mixed oil agent in step (2) at a linear speed of 50m/min to obtain a suspension containing 10% Dartnam dispersible oil. agent.

Comparative Example 10

This comparative example adopts the "synergizer I" in the prior art (CN101784184B, Example 1, trade name: Newco 12308LY), to provide a datnam oil suspending agent, and the quality content of its components is as follows: Dartnam 10% Newco 12308LY 10% Styryl phenol polyoxyethylene ether 10% Calcium dodecylbenzenesulfonate 4% Polycarboxylate 2% Silicone oil 1% Attapulgite 2% Soybean oil supplement 100%

Its preparation method refers to the preparation method of the oil suspension agent in Example 1. 4. Physical and chemical performance test

The dispersion stability test was carried out for the samples of the above examples 1-7. 5ml of the samples were added to a 250ml graduated cylinder containing standard water to dilute, and the standard water was used to make up to the 250ml scale line. In a water bath, observe the dilutions for 0.5 hours, 24 hours, and 24.5 hours (refer to CIPACMT180 method). The results of dispersion stability test are shown in Table 1. Table 1 sample Dispersion stability 0.5 hours 24 hours 24.5 hours Example 1 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml Example 2 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml Example 3 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml Example 4 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml Example 5 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml Example 6 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml Example 7 No grease, no sediment No grease, no sediment after redispersion Grease less than 0.5ml

As can be seen from Table 1, after the Dartnam oil suspension agent provided in Examples 1 to 7 of the present invention is diluted with water, there is no emulsion layering phenomenon and no destructive flocculation effect. The 24.5-hour test results show that it has good dispersion stability, meets the requirements of the CAPIC standard, and has very stable and good physical and chemical properties. 5. Biological activity test

The samples of the above Examples 1-7 and Comparative Examples 1-10 were respectively diluted with water to obtain an aqueous solution containing 10 mg/l (10 ppm) of datnam for use.

Test organisms:

3rd instar nymphs of brown planthopper. The adults were collected from the experimental field of the Academy of Agricultural Sciences in 2017, and were reared indoors with susceptible rice varieties for one year.

experiment method:

Using the rice stem dipping method. Dip the 10cm-long rhizomes (with some roots) in the medicinal solution for 30s, take them out and let them dry until there is no clear water on the stems, put them in an open cup with water, and seal the upper part with parafilm. Dipping in water was used as a control. Pick 3-instar N. lugens nymphs and put them in an open cup, with 7-14 heads per cup. The test temperature is 26±1℃, and the light L:D=16:8h. Check the number of live insects at 24h and 72h respectively. Each sample was repeated 3 times, and the average value was taken.

X 100%

X 100% Calculation method of drug effect:

X 100%

X 100%

The control effect on brown planthopper nymphs is shown in Table 2. Table 2 sample Dartnam Concentration (mg/L) Before medicine 1 day after the drug 3 days after the drug Average number of bugs Average number of bugs Decrease rate % Control effect% Average number of bugs Decrease rate % Control effect% Clear water control 0 10.00 9.33 6.70 - 9.00 10.00 - Example 1 10 11.33 4.33 61.78 59.04 0.67 94.09 93.43 Example 2 10 10.67 4.67 56.23 53.09 0.67 93.72 93.02 Example 3 10 12.00 4.67 61.08 58.29 0.67 94.42 93.80 Example 4 10 11.67 3.67 68.55 66.29 0.33 97.17 96.86 Example 5 10 9.33 3.00 67.85 65.54 0.33 96.46 96.07 Example 6 10 10.33 3.33 67.76 65.45 0.33 96.81 96.45 Example 7 10 12.00 4.00 66.67 64.27 0.33 97.25 96.94 Comparative Example 1 10 11.33 7.33 35.30 30.66 4.00 64.70 60.77 Comparative Example 2 10 11.67 7.67 34.28 29.56 4.00 65.72 61.92 Comparative Example 3 10 11.00 7.33 33.36 28.58 3.67 66.64 62.93 Comparative Example 4 10 10.00 5.67 43.30 39.23 2.67 73.30 70.33 Comparative Example 5 10 11.67 6.67 42.84 38.74 3.00 74.29 71.44 Comparative Example 6 10 9.33 5.33 42.87 38.77 2.33 75.03 72.25 Comparative Example 7 10 8.67 5.00 42.33 38.19 2.33 73.13 70.14 Comparative Example 8 10 12.33 8.33 32.44 27.59 4.36 64.64 60.71 Comparative Example 9 10 13.00 8.67 33.31 28.52 4.67 64.08 60.09 Comparative Example 10 10 11.33 5.73 49.43 45.79 2.00 82.35 80.39

As can be seen from Table 2, it can be seen from the synthesis of Examples 1 to 7 and Comparative Examples 1 to 9 that the Dartnam oil suspending agent provided in the embodiment of the present invention contains the general formula RO-(EO) _x- (PO) _y- The fatty alcohol ethoxylated propoxylate of OH is used as a synergist to enhance the activity of Dartnam oil suspending agent, enhance the insecticidal effect, and has excellent control effect on rice brown planthopper nymphs. Among them, 1 day after administration Its control effect on the brown planthopper can reach more than 53%, and the control effect after 3 days of administration can reach more than 93%; and the comparative examples 1 to 9 do not contain synergists, and the control effect on the brown planthopper when administered for 1 day. The highest was only 38.77%, and the highest control effect was only 72.25% after three days of administration, and the control effect on N. lugens was not good.

As can be seen from Table 2, it can be seen from the combination of Example 1 and Comparative Example 10 that although Comparative Example 10 contains a synergist, its control effect on N. lugens is only 49.43% when it is administered for 1 day, and the control effect after three days of administration is only 49.43%. It is also only 80.39%, while the control effect after 1 day and 3 days of administration in Example 1 is 59.09% and 93.43%, respectively, indicating that Example 1 adopts RO-(EO) _x- (PO) _y -OH. Fatty alcohol ethoxylated propoxylate as a synergist, compared with the Newco 12308LY synergist used in Comparative Example 10, can enhance the activity of datnam better, significantly improve the biological activity of datnam, Enhanced insecticidal effect.

To sum up, in the present invention, by adding a fatty alcohol ethoxylated propoxylate with the general formula RO-(EO) _x- (PO) _y -OH as a synergist in the Dartnam oil suspending agent, it is significantly The activity of Dartnam is improved, and the insecticidal control effect is enhanced. The control effect of three days of application can reach more than 93%, which can reduce the usage of pesticide active substances and relieve environmental pressure. The process is simple, the large-scale production is easy, the production cost is reduced, and the method has great economic value.

The applicant declares that the present invention illustrates the datnam-containing oil suspension agent of the present invention and its preparation method and use through the above-mentioned examples, but the present invention is not limited to the above-mentioned examples, that is, it does not mean that the present invention must rely on the above-mentioned examples. Examples can be implemented. Those skilled in the art should understand that any improvement of the present invention, the equivalent replacement of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

none

Claims (10)

A Dartnam oil suspending agent, characterized in that the oil suspending agent comprises the following components: A component: a solid Dartnam active at room temperature; B component: at least one of the general formula is RO-( Synergist for fatty alcohol ethoxylated propoxylates of EO) _x -(PO) _y -OH, wherein R is a C8~C20 alkyl group, EO is ethylideneoxy, and PO is propylidene oxide base, x is an integer of 1~20, y is an integer of 1~20; C component: nonionic surfactant and/or anionic surfactant; D component: any of vegetable oil, vegetable oil ester or aromatic hydrocarbon solvent one or a combination of at least two. The oil suspension agent according to claim 1, wherein R in the general formula RO-(EO) _x- (PO) _y -OH of the B component is a C8-C14 alkyl group; preferably , x in the general formula RO-(EO) _x- (PO) _y -OH is an integer from 2 to 16; Preferably, in the general formula RO-(EO) _x- (PO) _y -OH y is an integer from 2 to 16. The oil suspension agent according to claim 1 or 2, characterized in that, the oil suspension agent further comprises component E: additives; Preferably, the additive is any one or a combination of at least two of an emulsifier, a defoamer, a preservative, an antioxidant, a colorant or an inert filler; Preferably, the oil suspension agent further comprises F component: other pesticide actives; Preferably, the other pesticide actives are insecticides, preferably pyrethroid insecticides. The oil suspending agent according to any one of claims 1 to 3, characterized in that the oil suspending agent comprises the following components by weight: Component A: 1-30%; Component B: 1-15% %; C component: 1~15%; D component: 30~80%; E component: 0~20%; F component: 0~30%. The oil suspension agent according to claim 4, wherein the weight percentage of the A component is 5 to 25%; Preferably, the weight percentage of the B component is 2 to 10%; Preferably, the weight percent of the C component is 2~8%; Preferably, the weight percentage of the D component is 40-70%; Preferably, the weight percent of the E component is 1 to 15%; Preferably, the weight percentage of the F component is 5-25%. The preparation method of the Dartnam oil suspending agent according to any one of claims 1 to 5, wherein the preparation method is: the A component, the B component, the C component and the D component, and The optional components E and F are stirred and mixed to obtain a mixture, and then the mixture is ground to obtain an oil suspension. The preparation method according to claim 6, wherein the grinding temperature is 10 to 60 °C, preferably 15 to 45 °C; Preferably, the grinding is performed until the average particle size of the oil suspension agent is less than 8 μm, preferably 1-3 μm. A spray liquid, characterized in that, the spray liquid comprises the Dartnam oil suspension agent according to any one of claims 1 to 5. Use of the Dartnam oil suspension concentrate according to any one of claims 1 to 5 for plants and/or plant growth environments. The use of the Dartnam oil suspension agent according to any one of claims 1 to 5 for controlling insects; preferably, the insects to be controlled are Lepidoptera pests, Diptera pests, Hemiptera pests or the same Any one or a combination of at least two of the insect pests of the order Hemiptera is preferably a pest of the order Hemiptera, more preferably the brown planthopper.