TW202210806A - Magnetic extraction type biological sample collection method and system for water - Google Patents

Abstract

A biological sample collection method includes: arranging a magnetic extraction sample collecting device in a water tank unit or a sample water, with combining the magnetic extraction sample collecting device with the water tank unit; providing a ultra-sound generator in the sample water for generating ultra sound waves therein; transmitting a ultra sound wave to the sample water for shocking at least one material which is dropped in ultra-sound processed water; and utilizing the magnetic extraction sample collecting device to magnetically attract biological samples in the ultra-sound processed water to extract at least one attached biological sample.

Description

Magnetic suction type water biometric sample collection method and system

The present invention relates to a method and system for collecting biological samples from water bodies; in particular, it relates to a method and system for collecting biological samples from water bodies of a magnetic extraction type; more particularly, it relates to an ultrasonic type [ultrasound type] A method and system for collecting biological characteristic samples of water bodies.

For example, conventional magnetic bead-based biosensing methods and devices, such as the invention patent application "Excitation and Measurement Method for a Magnetic Biosensor" of US Patent Publication No. US-20090206825, discloses a digital magnetic sensor system. The digital magnetic sensor system includes at least one digital magnetic sensor element and a processor.

In connection with the above, the digital magnetic sensor element of the aforementioned US-20090206825 includes a magnetic element, a bit line and a word line, and the word line is oriented to be orthogonal to the bit line, and the A digital magnetic sensor element is used to sense the presence of a magnetic bead near a top surface. The processor communicates with the digital magnetic sensor element, and is used for executing program data, and when executing the program data, a method for sensing the presence of magnetic beads is generated.

Continuing from the above, when the processor of the aforementioned US-20090206825 executes the program data, the execution items include: measuring an initial state of the magnetic element of the digital magnetic sensor element; controlling to respectively provide a predetermined current pulse to the The bit line of the digital magnetic sensor element and each of the word lines, the current pulse can switch the magnetic element of the digital magnetic sensor element measuring a first state of the magnetic element of the digital magnetic sensor element after supplying the current pulse; and comparing the measurements between the first state and the initial state, and providing a comparison result.

Another conventional magnetic bead-based biosensing method and device therefor, such as the invention patent application "Biosensor Based on the Measurements of Clustering Dynamics of Magnetic Particles Using a Double Pass Setup" in US Patent Publication No. US-20160146798, which discloses A biosensor based on dynamic measurement of magnetic particle clusters using a dual-pass setting and an operation method thereof. The biosensor is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission.

Continuing from the above, the biosensor of the aforementioned US-20160146798 includes a plurality of magnetic particles, and is functionalized with the bioligands of the plurality of magnetic particles, so that it can detect a target analyte in a sample , and the biosensor can be implemented in a configuration of a magnetic disk and an optical pickup.

Another conventional magnetic bead-based biosensing method and device thereof, such as the invention patent application "Biomolecule Magnetic Sensor" of US Patent Publication No. US-20180067175, discloses a biomolecular magnetic sensor, and the biomolecular magnetic The sensor is used for sensing at least one biomolecule to be tested, and several nano-magnetic beads are attached to the biomolecule to be tested. The biomolecule magnetic sensor includes an adsorption sheet and a magnetic force line generator.

Based on the above, the adsorption sheet of the aforementioned US-20180067175 is used for attaching the nanomagnetic beads, and the magnetic field line generator is used for generating a plurality of first magnetic field lines, and at least one of the first magnetic field lines passes through the nanoparticle in a first direction. magnetic beads, so that the nano magnetic beads induce one of the first magnetic force lines to generate several second magnetic force lines. The magnetic line generator is located between the adsorption piece and at least one magnetic sensing element in the first direction, and the magnetic sensing element and the adsorption piece have a first offset and a second offset in different directions shift.

Based on the above, the magnetic sensing element of the aforementioned US-20180067175 is disposed on at least one of the second magnetic lines of force, and the magnetic sensing element senses a magnetic field component of at least one of the second magnetic lines of force in a second direction. The magnetic sensing element is disposed at a position where the magnetic field component of at least one of the second magnetic lines of force in the second direction is not zero, and the first direction and the second direction are different, and the magnetic sensing element and the adsorption piece are in The second direction has the second offset.

Another conventional ultrasonic biosensing method and system therefor, such as the invention patent application "Sensor System for Determining Concentration of Chemical and Biological Analyses" in US Patent Publication No. US-20100167412, which discloses a method for measuring chemical and biological Sensing systems for the concentration of biological analytes. The sensor system includes a disposable reagent delivery element, at least one light source, at least one light detector and an electronic circuit component, and an ultrasonic generator is embedded in the sensor system.

Continuing from the above, the disposable reagent delivery member of the aforementioned US-20100167412 is detachably assembled with a liquid handling unit, and the liquid handling unit can draw liquid back into the disposable reagent delivery member. The photodetector can generate an electronic signal response indicating light is generated through or from an interior space of the disposable reagent delivery member, and the electronic circuit components are used for processing, storage and send the electronic signal in response, and the electronic circuit component controls the light source.

Another conventional ultrasonic biosensing method and system thereof, such as the invention patent of "Biosensor and ultrasonic method of making a biosensor" of US Patent Publication No. US-7972866, which discloses a test strip for testing fluid samples and a method for manufacturing a biosensor.

Continuing from the above, the test strip for testing fluid samples of the aforementioned US-7972866 includes a sample cavity and an ultrasonic dispersion reagent layer. The sample chamber is configured to receive a fluid sample, and the ultrasonic dispersion test The agent layer is disposed on at least one surface of the sample cavity.

Continuing from the above, the method for manufacturing a biosensor of the aforementioned US-7972866 includes: providing a substrate, and the substrate has a sample receiving area, and the sample receiving area is used for receiving a sample; The liquid substance is dispensed on at least one surface of the sample receiving area; and an ultrasonic wave is used to vibrate the substrate, so that the liquid substance is quickly and uniformly dispersed on at least one surface of the sample receiving area.

Another conventional ultrasonic biosensing method and device, such as the invention patent application "Magnetic Biosensing Device and Biosensing Method" in Patent Publication No. TW-202024630 of the Republic of China, which discloses a magnetic biosensing device. The magnetic biological sensing device includes a flow channel, a magnetic sensor and an acoustic wave transmitter.

Continuing from the above, the magnetic sensor of the aforementioned No. TW-202024630 is correspondingly disposed in the flow channel, and the acoustic wave transmitter includes two acoustic wave generating units, and the flow channel is disposed between the two acoustic wave generating units. The acoustic wave transmitter is used for generating an ultrasonic standing wave in the flow channel, and the magnetic sensor corresponds to a node position of the ultrasonic standing wave.

However, the aforementioned US Patent Publication Nos. US-20090206825, US-20160146798, US-20180067175, US-20100167412, US Patent Publication US-7972866 and ROC Patent Publication No. TW-202024630 The biosensing method and its system are not suitable for application in water biometric sample collection technology, so there must be a potential demand for further improvement of the overall structure.

The aforementioned invention patents of US Patent Publication No. US-20090206825, US-20160146798, US-20180067175, US-20100167412, US Patent Publication US-7972866 and ROC Patent Publication No. TW-202024630 The patent application and the invention are only for reference of the technical background of the present invention and to illustrate the current state of technological development, and are not intended to limit the scope of the present invention.

In view of this, in order to meet the above-mentioned needs, the present invention provides a magnetic suction type water body biological characteristic sample collection method and system thereof, wherein a magnetic suction type biological sample collection device is arranged in a water body container unit or a water body to be collected samples, Combine an ultrasonic generating device with the water body to be collected, and use the ultrasonic generating device to ultrasonically vibrate at least one water body to be treated in the water body to be collected, and then use the magnetic suction biological sample collecting device to collect At least one ultrasonically treated water body of the water body to be collected is adsorbed and treated, so that the magnetic suction type biological sample collection device can collect at least one adsorbed biological sample, so as to improve the problems of conventional biological sensing methods and systems.

The main purpose of the preferred embodiments of the present invention is to provide a magnetic suction type water body biological characteristic sample collection method and system, wherein a magnetic suction type biological sample collection device water body is arranged in a water body container unit or a sample to be collected, and the An ultrasonic generating device is combined with the water body to be collected, and the ultrasonic generating device is used to ultrasonically vibrate at least one water body to be treated in the water body to be collected, and then the magnetic suction biological sample collecting device is used to collect adsorption treatment At least one of the water bodies to be collected samples has been ultrasonically treated, so that the magnetic suction type biological sample collection device can collect at least one adsorbed biological sample, so as to achieve the purpose of improving the magnetic suction type water body biological characteristic sample collection.

In order to achieve the above purpose, the magnetic suction type water biometric sample collection system according to the preferred embodiment of the present invention includes:

a water body container unit for accommodating a water body to be sampled;

at least one magnetic suction type biological sample collection device, which is configured in the water body container unit or the water body to be sampled; and

at least one ultrasonic generating device, which is combined with the water body to be sampled;

wherein at least one water body to be treated of the sample water body to be collected is ultrasonically vibrated by the ultrasonic generating device, so that at least one shattered substance of the sample water body to be collected falls into at least one ultrasonically treated water body, and The magnetic suction type biological sample collection device is used to collect and adsorb at least one ultrasonically treated water body of the water body to be collected, so that the magnetic suction type biological sample collection device can collect and obtain at least one adsorbed biological sample.

The water body container unit of a preferred embodiment of the present invention is selected from an aquaculture tank unit, an aquarium display tank unit, a culture tank unit, an aquarium display tank unit or any combination thereof.

In a preferred embodiment of the present invention, the magnetically attractable biological sample collection device is selected from a magnetic bead chamber device, a magnetically attractable carrier combined with a magnetic bead device, a recirculating fluid body or any combination thereof.

The circulatable fluid body of the preferred embodiment of the present invention has a circulatable fluid region or a circulatable fluid channel.

The magnetic suction type biological sample collection device according to a preferred embodiment of the present invention is connected to the water body container unit via a conveying pipeline.

In the preferred embodiment of the present invention, the conveying pipeline has a valve device or a switching valve device.

In a preferred embodiment of the present invention, the conveying pipeline is combined with a gas conveying device.

In order to achieve the above purpose, the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention includes:

Disposing a magnetic suction biological sample collecting device in a water body container unit or a water body to be sampled, and combining the magnetic suction biological sample collecting device with the water body container unit or the water body to be sampled;

combining an ultrasonic generating device with the sample water body to be collected, so as to transmit an ultrasonic wave to the sample water body to be collected;

Ultrasonic vibration treatment using the ultrasonic generating device At least one water body to be treated of the water body to be sampled, so that at least one crushed substance of the water body to be collected sample falls into at least one ultrasonically treated water body; and

The magnetic suction type biological sample collecting device is used to collect and adsorb the ultrasonically treated water body of the water body to be sampled, so that the magnetic suction type biological sample collecting device can collect and obtain at least one adsorbed biological sample.

In a preferred embodiment of the present invention, the adsorbed biological sample is obtained from at least one adsorbed biological sample magnet, at least one adsorbed biological sample magnetic bead, or any combination thereof.

In a preferred embodiment of the present invention, the magnetic suction type biological sample collecting device is submerged in the ultrasonically treated water body of the water body container unit.

The magnetic suction type biological sample collection device according to the preferred embodiment of the present invention is connected to the water container unit through a conveying pipeline, so that the ultrasonically treated water body can be conveyed to the magnetic suction type biological sample collection device through the conveying pipeline .

In a preferred embodiment of the present invention, the conveying pipeline is combined with a gas conveying device, so as to use the gas conveying device to convey a bubble flow to the water container unit or the water body to be sampled through the conveying pipeline.

1: Water body container unit

10: Water body to be collected sample

11: Tissue debris

12: Bubble Stream

2: Magnetic suction type biological sample collection device

20: Magnetically attractable carrier

20a: Circulating fluid body

20b: Circulating fluid zone

201: Magnetically attractable area

21: Magnetic beads

22: Gas delivery device

23: Delivery pipeline

3: Ultrasonic generating device

31: Buoyancy device

Figure 1: A schematic diagram of a magnetic suction type water biometric sample collection system according to the first preferred embodiment of the present invention.

Fig. 2: A block diagram of the flow chart of the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention.

Figure 3: A schematic diagram of selecting the first magnetic suction type biological sample collection device for the magnetic suction type water biological characteristic sample collection system according to the preferred embodiment of the present invention.

Figure 4: The magnetic suction type water biological characteristic sample collection system according to the preferred embodiment of the present invention selects the second magnetic suction type biological sample collection device intention.

Fig. 5 is a schematic diagram of a magnetic suction type water biometric sample collection system according to the second preferred embodiment of the present invention.

In order to fully understand the present invention, preferred embodiments will be exemplified below and described in detail in conjunction with the accompanying drawings, which are not intended to limit the present invention.

First of all, the magnetic suction type water biometric sample collection method and system thereof according to the preferred embodiment of the present invention can be applied to various aquatic (or marine) biological restoration industries, various aquatic (or marine) biological seedling breeding industries, various aquatic (or marine) organisms Marine] biological seedlings or fish transportation industry, various aquatic (or marine) biological seedlings or adult sales, various aquatic (or marine) biological seedlings or adult display industry or related aquatic (or marine) biological seedling industries, However, it is not intended to limit the application scope of the present invention.

For example, the magnetic suction type water biometric sample collection method and system of the preferred embodiment of the present invention can be applied to the collection of seedlings or adult samples of various aquatic organisms, the collection of seedlings or adult samples of various aquatic organisms, various The collection of algae samples from freshwater or marine waters, the collection of various freshwater or marine cultured algae samples, or the collection of samples from various freshwater or seawater waters is not intended to limit the scope of application of the present invention.

FIG. 1 shows a schematic diagram of a magnetic suction type water biometric sample collection system according to a first preferred embodiment of the present invention. Referring to FIG. 1, for example, the magnetic suction type water biological sample collection system according to the first preferred embodiment of the present invention mainly includes a water body container unit 1, at least one magnetic suction type biological sample collection device 2 and at least one An ultrasonic generating device 3 .

Please refer to FIG. 1 again. For example, the water container unit 1 is used for accommodating a water body 10 to be collected and several aquatic organisms (not marked), and the water container unit 1 is selected from a culture water tank unit , an aquarium display tank unit, an aquaculture tank unit, an aquarium display tank unit or any combination thereof.

Please refer to FIG. 1 again. For example, the magnetic biological sample collection device 2 is arranged in the water container unit 1 or the appropriate position of the water body 10 to be sampled by appropriate technical means, and the magnetic biological sample collection device 2 The sample collection device 2 is selected from a magnetic bead chamber device, a magnetically attractable carrier combined with a magnetic bead device, a recirculating fluid body or any combination thereof.

Please refer to FIG. 1 again. For example, the ultrasonic generating device 3 is selected to generate ultrasonic waves of a predetermined frequency (for example: 25KHz to 200KHz), and output a predetermined power ultrasonic wave (for example: continuous or pulsed) Ultrasonic wave] to a predetermined time, and the ultrasonic generating device 3 is combined with the water body 10 to be sampled in the water body container unit 1 by appropriate technical means.

Referring to FIG. 1 again, for example, the magnetic suction type biological sample collection device 2 and the ultrasonic generating device 3 are selected and assembled by appropriate technical means to form a composite device assembly unit, and the composite device is assembled The unit can be selected from a single integral molding unit, a detachable assembly unit or other various forms of assembly units.

Please refer to FIG. 1 again, for example, when the predetermined frequency ultrasonic wave of the ultrasonic wave generating device 3 can be used to impact the inner wall surface material (not shown) of the water body container unit 1 and the water body 10 to be sampled The body surface bacteria (not shown), parasites (not shown) or tissue debris (tissue) 11 containing impurities (not shown) and aquatic products can also be cleaned at the same time.

FIG. 2 shows a block diagram of the flow chart of the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention, which is correspondingly applicable to the magnetic suction type water body biometric sample collection system of FIG. 1 . Referring to Figures 1 and 2, the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention includes step S1: First, for example, by appropriate technical means [such as: automated, semi-automated or Manual method] Dispose the magnetic suction type biological sample collection device 2 in the water container unit 1 or its to-be-collected The sample water body 10 is collected, and the magnetic suction biological sample collection device 2 is combined with the water body container unit 1 or the sample water body 10 to be collected by appropriate technical means (eg, fixed type or movable type).

Please refer to Figures 1 and 2 again, the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention includes step S2: using appropriate technical means (for example: automated, semi-automated or manual) The ultrasonic generating device 3 is combined with the water body 10 to be sampled in the water container unit 1 , so as to properly transmit an ultrasonic wave to the water body 10 to be sampled in the water container unit 1 .

Please refer to Figures 1 and 2 again, the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention includes step S3: Next, for example, using appropriate technical means [such as: automatic method, semi-automatic method or manual method] use the ultrasonic generating device 3 to perform ultrasonic vibration treatment of at least one water body to be treated in the water body 10 to be collected sample, so that at least one shattered substance of the water body 10 to be collected sample falls into at least one of the water bodies that have been collected. Ultrasonic treatment of water bodies.

Please refer to Figures 1 and 2 again, the magnetic suction type water biometric sample collection method according to the preferred embodiment of the present invention includes step S4: Next, for example, using appropriate technical means [such as: automatic method, semi-automatic method Or manual method] use the magnetic suction type biological sample collection device 2 to collect and adsorb the ultrasonically treated water body of the water body 10 to be collected from the water body container unit 1, so as to facilitate the magnetic suction type biological sample collection device 2 to collect at least An adsorbed biological sample.

Referring to Figures 1 and 2 again, for example, the adsorbed biological sample is obtained from at least one adsorbed biological sample magnet, at least one adsorbed biological sample magnetic bead, or any combination thereof. In addition, the magnetic suction type biological sample collection device 2 can optionally be submerged in the ultrasonically treated water body of the water body container unit 1 .

Please refer to Figures 1 and 2 again, for example, the magnetic attraction The biological sample collecting device 2 of the type 2 can be optionally submerged in the water body 10 to be collected sample or the water body that has been ultrasonically treated, which is arranged in the water body container unit 1 to a predetermined sampling depth and a predetermined sampling position; similarly, the ultrasonic generating device 3. It can be selected to be properly submerged in the water body 10 to be sampled or the water that has been ultrasonically treated and set in the water body container unit 1 to a predetermined sampling depth and a predetermined sampling position.

Referring to Figures 1 and 2 again, for example, the adsorbed biological sample of the magnetic suction biological sample collection device 2 includes the water body container unit generated by the ultrasonic shock or vibration treatment performed by the ultrasonic generator 3 1. The material on the inner wall, the surface bacteria, parasites or tissue debris 11 containing impurities and aquatic products in the water body 10 to be sampled.

FIG. 3 shows a schematic diagram of selecting the first magnetic biological sample collection device for the magnetic suction type water biological characteristic sample collection system according to the preferred embodiment of the present invention, which is correspondingly applicable to the magnetic suction type biological sample collection device of FIG. 1 . Please refer to FIG. 3, for example, the magnetic suction type water biological characteristic sample collection system of the preferred embodiment of the present invention selects a first magnetic suction type biological sample collection device, and the first magnetic suction type biological sample The collection device includes at least one or several magnetically attractable carriers 20 and several magnetic beads 21, and optionally includes a magnetic bead removal device (not shown), a sample dissolution device [ not shown] or a device with a similar function.

Please refer to FIG. 3 again, for example, the magnetically attractable carrier 20 has at least one or several magnetically attractable regions 201 , and at least one or several of the magnetically attractable regions 201 correspond to several of the magnetic beads twenty one. In another preferred embodiment of the present invention, the magnetically attractable carrier 20 is selected from a rod, a piece, a sphere, an ellipsoid (rugby ball), a piece, an object of any geometric shape or any combination thereof.

Referring to FIG. 3 again, for example, the magnetic beads 21 can be properly adsorbed and disposed on the magnetically attractable area 201 of the magnetically attractable carrier 20 . Other In addition, the magnetic bead 21 is selected to be made of an appropriate material (eg, triiron tetroxide or other magnetic materials), and the magnetic bead 21 is selected to have a diameter of an appropriate size, and the magnetic bead 21 has an appropriate appearance and shape, such as: irregular surface.

Please refer to Fig. 3 again, for example, the magnetic bead 21 (shown in the schematic frame of Fig. 3) can be selected from a magnetic bead with a chemically modified surface, and the chemically modified surface of the magnetic bead 21 is appropriately selected It has various functional groups such as amine, carboxyl or hydroxyl. In this way, the surface of the magnetic beads 21 can adsorb different microorganisms or biomolecules, but it is not intended to limit the application scope of the present invention.

FIG. 4 shows a schematic diagram of selecting a second magnetic biological sample collection device in the magnetic suction type water biological sample collection system according to the preferred embodiment of the present invention, which is correspondingly applicable to the first magnetic suction biological sample collection in FIG. 3 device. Please refer to FIG. 4 , for example, the magnetic suction type water biological characteristic sample collection system according to the preferred embodiment of the present invention selects a second magnetic suction type biological sample collection device, and the second magnetic suction type biological sample The collection device includes at least one or more fluid-circulating bodies 20a and a plurality of magnetic beads 21, and optionally includes a magnetic bead removal device (not shown), a sample dissolution device [not shown] or a device with a similar function.

Please refer to FIG. 4 again, for example, the circulatable fluid body 20a has at least one or more circulatable fluid regions 20b or at least one or more circulatable fluid passages, and at least one or more Each of the recirculatable fluid regions 20b or recirculatable fluid channels corresponds to several of the magnetic beads 21 .

Referring to FIG. 4 again, for example, the at least one or more circulatable fluid regions 20b or at least one or more circulatable fluid channels can be selectively arranged on the outer surface and side end surface of the circulatable fluid body 20a , inner wall surface, interior or other suitable positions, but it is not intended to limit the scope of the present invention.

Referring to FIG. 4 again, for example, the recirculatable fluid body 20a of another preferred embodiment of the present invention is selected from a bottle, a box, a tube, a cavity, a sphere, a An ellipsoid (rugby ball), a floating ball, a buoy, a container body that can be placed in water (eg: closed or semi-open container body) or any combination thereof.

Referring to FIG. 4 again, for example, the circulatable fluid region 20b or the circulatable fluid channel of the circulatable fluid body 20a can be optionally configured with at least one or several magnetically attractable regions or a similar magnetic attraction It is a functional device so as to magnetically attract several magnetic beads 21 randomly or regularly, but it is not intended to limit the scope of the present invention.

Please refer to FIG. 4 again, for example, in the system setting, the recirculatable fluid body 20a can be selected from a floatable recirculating fluid main body, a movable recirculating fluid main body or a fixed recirculating fluid main body , but it is not intended to limit the scope of the present invention.

Please refer to FIG. 4 again, for example, the circulatable fluid body 20a can be optionally configured with at least one or more chambers, at least one or more fluid inlets or fluid inlets. The input pipe and at least one or more fluid outlets or fluid output pipes are not intended to limit the scope of the present invention.

FIG. 5 shows a schematic diagram of a magnetic suction type water biometric sample collection system according to a second preferred embodiment of the present invention. Referring to FIG. 5, compared to the first embodiment, the magnetic suction type water biometric sample collection system according to the second preferred embodiment of the present invention further includes a gas conveying device 22 and a conveying pipeline 23, and the conveying The pipeline 23 is combined with the gas delivery device 22, so as to use the gas delivery device 22 to deliver a bubble flow 12 to the water container unit 1 or the water body to be sampled through the delivery pipeline 23, so that the water container unit 1 is to be collected A circulating water flow is generated in the sample water body, and the circulating water flow is guided through the interior of the magnetic suction type biological sample collecting device 2 . In addition, the conveying pipeline 23 has a valve device (not shown) or a Switching valve device (not shown).

Please refer to FIG. 5 again, for example, the ultrasonic generating device 3 has a buoyancy device 31 or other devices that provide buoyancy, and the buoyancy device 31 is combined with the ultrasonic generating device 3 by appropriate technical means, In order to float the ultrasonic generating device 3 in the water container unit 1 or the water body to be collected.

The aforementioned preferred embodiment is only an example of the present invention and its technical features, and the technology of this embodiment can still be implemented in various substantially equivalent modifications and/or alternative ways; therefore, the scope of the right of the present invention is subject to the appended patent application The scope defined by the scope shall prevail. The copyright in this case is restricted to be used for the purposes of the ROC patent application.

1: Water body container unit

10: Water body to be collected sample

11: Tissue debris

2: Magnetic suction type biological sample collection device

3: Ultrasonic generating device

Claims (10)

A magnetic suction type water biometric sample collection system, comprising: a water body container unit for accommodating a water body to be sampled; at least one magnetic suction-type biological sample collection device, which is disposed in the water body container unit or the water body to be sampled; and at least one ultrasonic generating device, which is combined with the water body to be sampled; wherein at least one water body to be treated of the sample water body to be collected is ultrasonically vibrated by the ultrasonic generating device, so that at least one shattered substance of the sample water body to be collected falls into at least one ultrasonically treated water body, and The magnetic suction type biological sample collection device is used to collect and adsorb at least one ultrasonically treated water body of the water body to be collected, so that the magnetic suction type biological sample collection device can collect and obtain at least one adsorbed biological sample. According to the magnetic suction type water biological feature sample collection system described in item 1 of the scope of application, wherein the magnetic suction type biological sample collection device is selected from a magnetic bead chamber device, a magnetically attractable carrier combined with a magnetic bead device, a Circulating fluid body or any combination thereof. According to the magnetic suction type water biological characteristic sample collection system described in item 1 of the scope of application, wherein the magnetic suction biological sample collection device is connected to the water body container unit through a conveying pipeline. According to the magnetic suction type water biological feature sample collection system described in item 3 of the patent application scope, the conveying pipeline has a valve device or a switching valve device. According to the magnetic suction type water biological feature sample collection system described in item 3 of the application scope, the conveying pipeline is combined with a gas conveying device. A magnetic suction type water biological feature sample collection method, comprising: Disposing a magnetic suction biological sample collecting device in a water body container unit or a water body to be sampled, and combining the magnetic suction biological sample collecting device with the water body container unit or the water body to be sampled; combining an ultrasonic generating device with the sample water body to be collected, so as to transmit an ultrasonic wave to the sample water body to be collected; Utilize the ultrasonic generating device to ultrasonically vibrate at least one water body to be treated in the water body to be sampled, so that at least one shattered substance of the water body to be collected sample falls into at least one ultrasonically treated water body; and The magnetic suction type biological sample collection device is used to collect and adsorb the ultrasonically treated water body of the water body to be collected, so that the magnetic suction type biological sample collection device can collect and obtain at least one adsorbed biological sample. According to the magnetic suction type water biometric sample collection method described in item 6 of the claimed scope, the adsorbed biological sample is obtained from at least one adsorbed biological sample magnet, at least one adsorbed biological sample magnetic bead, or any combination thereof. According to the magnetic suction type water biological characteristic sample collection method described in item 6 of the patent application scope, the magnetic suction type biological sample collection device is immersed in the ultrasonically treated water body of the water body container unit. According to the magnetic suction type water biological characteristic sample collection method described in item 6 of the scope of the application, wherein the magnetic suction type biological sample collection device is connected to the water body container unit through a conveying pipeline, so that the ultrasonically treated water body can pass through the water body. The conveying pipeline is conveyed to the magnetic suction type biological sample collection device. According to the magnetic suction type water biometric sample collection method described in item 9 of the scope of application, wherein the conveying pipeline is combined with a gas conveying device, so as to use the gas conveying device to convey a bubble flow to the water container through the conveying pipeline unit or water body to be sampled.

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