TW202123954A - Composition for maintaining or improving daily life activity amount, or for preventing or suppressing decrease in daily life activity amount - Google Patents

Abstract

The purpose of the present invention is to provide: a composition for maintaining or improving a daily life activity amount, or for preventing or suppressing any decrease in a daily life activity amount; a method for maintaining or improving a daily life activity amount, or for preventing or suppressing any decrease in a daily life activity amount; and a use of one or more sesamins for maintaining or improving a daily life activity amount, or for preventing or suppressing any decrease in a daily life activity amount. The present invention relates to a composition that includes one or more sesamins and that is for maintaining or improving a daily life activity amount, or for preventing or suppressing any decrease in a daily life activity amount.

Description

Composition for maintenance, prevention of decrease, suppression of decrease or improvement of living activity level

The present invention relates to a composition for maintaining, preventing, inhibiting, or improving the amount of living activity. In addition, the present invention relates to a method for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity, and the use of one or more sesamins for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity.

In recent years, how to improve living habits in countries around the world, including Japan, has become an important issue. In addition, for countries with a high proportion of elderly people in the population structure, such as Japan, extending healthy life expectancy has also become an important issue. Under such circumstances, Japan promotes continuous exercise to prevent diseases (civilization diseases) caused by lifestyle habits, and to increase muscle strength to prolong healthy life. Furthermore, in recent years, those who have low psychological barriers to start exercising and can easily take the first step have also recommended increasing the amount of physical activity in their daily lives. For example, some people recommend walking or housework during commuting or school as activities that most people can easily perform in their daily lives.

Here, according to the "Guidelines for Health Promotion Exercise 2006" issued by the Ministry of Health, Labour and Welfare of Japan, physical activity means "all behaviors that consume more energy than when staying still" and are defined as sports and life activities. By. Life activity is defined as "something other than exercise during physical activity." In addition, the intensity of physical activity is multiplied by the time spent on the activity, which is expressed as the amount of physical activity.

In addition, according to the Health and Labor White Paper (2014 edition) issued by the Ministry of Health, Labour and Welfare of Japan, healthy life span is defined as "a period during which one can live without restrictions on daily life due to health problems"; those who can live without care The period of life is synonymous with the period of unrestricted life activities. Therefore, with age, the possibility of obstacles in life activities will increase. For example, Non-Patent Document 1 discloses that with age, the amount of life activity decreases. Non-Patent Document 3 discloses that the higher the amount of physical activity, the longer the healthy life span. Therefore, in an aging society, it is required to maintain physical activity through exercise and maintenance of life activity, and to extend the healthy life span.

In addition, the amount of physical activity of a person can be measured with the number of steps as a basic indicator. For example, in animal experiments, the mainstream is to measure the number of movement by infrared rays, or measure the movement distance by telemetry. However, the assessment of the amount of life activity that does not include exercise also requires low-intensity activity assessment. In recent years, some people have developed a measurement method that uses a built-in activity meter in a three-axis acceleration sensor as a measurement method of human life activity. By using this measurement method, low-intensity activities can also be accurately measured, so it can be used as an indicator to more accurately measure the amount of life activity. Using this measurement method, it has been confirmed that the amount of human life activity decreases with age (Non-Patent Document 1). [Prior Technical Literature] [Non-Patent Literature]

[Non-Patent Document 1] Kumagai Akizo, Tanaka Shigeho, Kishimoto Hiroho et al. Investigation of the amount of physical activity using the built-in activity of the three-axis acceleration sensor, the investigation of static behavior (Sedentary Behavior) and the epidemiology of physical activity Application of Research. Sports Epidemiology Research 2015; 17(2): 90-103. [Non-Patent Document 2] Takada S, Kinugawa S, Matsushima S, et al. Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes. Exp Physiol. 2015 Nov 1; 100 (11): 1319-1330 [Non-Patent Document 3] Leskinen T, Stenholm S, Aalto V, et al. Physical activity level as a predictor of healthy and chronic disease-free life expectancy between ages 50 and 75. Age Ageing 2018 May 1; 47(3)423 -429

[The problem to be solved by the invention]

It was confirmed in Non-Patent Document 2 that sesamin can inhibit the decrease in endurance when an exercise stress test is performed on rats fed a high-fat diet. However, no one has reported that sesamin can prevent the decrease in the amount of life activity during physical activity, rather than the decrease in the amount of exercise, and help maintain the amount of life activity. That is, it is not known that sesamins such as sesamin have the function of maintaining the amount of living activity. In particular, it has not been reported that sesamin, such as sesamin, contributes to the maintenance of the decrease in the amount of living activity associated with aging.

The present invention aims to provide a composition for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity. In addition, the present invention aims at a method for maintaining, preventing, reducing, suppressing, or improving the amount of living activity, and the use of one or more sesamins for maintaining, preventing, preventing, suppressing, or improving the amount of living activity. [Means to solve the problem]

In order to solve the above-mentioned problems, the inventors of the present case have devoted themselves to research. By using the built-in activity meter of the three-axis acceleration sensor shown in Non-Patent Document 1, the activity level of rats was measured without exercise burden. Primitives have the function of maintaining the amount of physical activity other than exercise, that is, the amount of life activity. In addition, the inventors of the present application found that sesamin is useful for preventing or maintaining the decrease in the amount of living activity due to aging.

The present invention relates to a composition for maintaining, preventing decrease, suppressing decrease, or improving the following living activity level. [1] A composition for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity, which contains one or more kinds of sesamin. [2] The composition according to the above [1], wherein one or more types of sesamin are sesamin and/or episesamin. [3] The composition according to the above [1] or [2], wherein one or more of the sesamins are episesamin. [4] The composition as described in any one of [1] to [3] above, which is used to prevent or suppress the decrease in the amount of life activity that accompanies aging, improve the amount of life activity that accompanies aging, Prevent or suppress the increase in inactive time associated with aging, and improve the increase in inactive time associated with aging. [5] The composition according to any one of [1] to [4] above, which is a composition for oral administration. [6] The composition according to the above [5], wherein the composition for oral administration is a food or drink, a medicine, a quasi-drug, or a feed. [7] The composition according to [6], wherein the above-mentioned food and drink are foods for specific health use, foods with nutritional functions, or foods with functional labeling. [8] A method for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity, which administers one or more kinds of sesamin. [9] The use of one or more kinds of sesamin, which is used to maintain, prevent decrease, suppress decrease or improve the amount of living activity. [Effects of Invention]

According to the present invention, it is possible to provide a composition for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity. Furthermore, according to the present invention, it is possible to provide a method for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity. Furthermore, according to the present invention, it is possible to provide the use of one or more sesamins for the maintenance of living activity level, prevention of decrease, suppression of decrease, or improvement. If one or more types of sesamin are taken, the effect of maintaining, preventing decrease, suppressing decrease or improving the amount of living activity can be obtained. In addition, if one or more of sesamin is taken, it can prevent or suppress the decrease in the amount of living activity that accompanies aging, improve the amount of living activity that accompanies aging, or prevent, suppress, or improve the decline in life activity that accompanies aging. The increase in inactive time. The sesamin used in the present invention is an ingredient that has been taken in the form of food since ancient times, and it is also advantageous in terms of high safety and sustainable ingestion.

[The form of implementing the invention]

The composition system for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity of the present invention contains one or more kinds of sesamin. Sesamin is one of the main lignan compounds in sesame, and contains about 0.5 to 1.0% by weight in sesame. Long-term intake of synthetic compounds is not good based on unpredictable side effects. On the other hand, sesamin, which can ensure safety, is suitable for long-term intake.

In the present invention, physical activity, exercise, and life activity have the same meaning as the definitions of physical activity, exercise, and life activity in the "Health Promotion Guide 2006" issued by the Ministry of Health, Labour and Welfare of Japan. In other words, physical activity refers to all behaviors that consume more energy than when remaining still, and life activity refers to all activities other than exercise. In addition, exercise refers to those who are planned or deliberately performed for the purpose of maintaining or improving physical strength, for example. The amount of living activity can be measured with a built-in activity meter (Actimarker manufactured by Panasonic) for humans, for example. For animals, it can be measured using a three-axis acceleration sensor built-in activity meter (nanotag manufactured by KISSEI COMTEC Co., Ltd.) without applying exercise such as treadmills.

The life activities in the present invention are not particularly limited. For example, humans may include housework, work, and/or childcare activities. As far as animals are concerned, the amount of activity measured under the condition of no exercise is equivalent to the so-called living activity amount of human beings.

Furthermore, in the present invention, the amount of life activity can be measured by the amount of life activity and/or the time of life activity. That is, the maintenance, prevention of reduction, inhibition of reduction or improvement of the amount of living activity refers to the maintenance, prevention of reduction, inhibition of reduction or improvement of the amount of living activity and/or life activity time. In addition, since the decrease (decrease) of life activity time will lead to the increase of inactive time, the maintenance, prevention of decrease, suppression of decrease or improvement of life activity amount in the present invention also includes prevention, suppression or improvement of increase of inactivity time. In addition, the inactive time mentioned in this manual refers to the time during which no physical activity is performed, that is, the time during which sleep or static behavior remains static.

The maintenance, prevention of decrease, suppression of decrease or improvement of the above-mentioned living activity level is preferably to prevent or restrain the decrease of living activity level, improve the reduced living activity level, prevent or inhibit the increase of inactive time, or improve the increased inactive time.

Furthermore, the maintenance, prevention, reduction, suppression, or improvement of the above-mentioned living activity level is preferably to prevent or inhibit the reduction in living activity level accompanying aging, to improve the reduction in living activity level accompanying aging, and to prevent or inhibit aging. Increase in inactive time due to growth, improve the inactive time that increases with age. In addition, the term “age increase” in the present invention refers to the changes that occur with the increase of age after the age of about 40 years old and above.

(Sesamin) In the present invention, sesamins refer to the general term for compounds including sesamin and its analogs. Sesamin is one of the main lignan compounds contained in sesame. As the sesamin analogs, in addition to episesamin, for example, dioxabicyclo[3.3.0]octane derivatives described in JP 4-9331 A can be cited. Regarding one or more types of sesamin, one type of compound may be used alone, or two or more types may be used. Specific examples of sesamin include sesamin, episesamin, sesame lignan, episesame lignan, sesamol, sesalin, etc., and these stereoisomers or racemates can be used alone or in combination. . Moreover, sesamin metabolites (such as those described in JP 2001-139579 A), as long as they can show the effects of the present invention, are also sesamin analogs included in the sesamin class of the present invention, and can Used in the present invention. In the present invention, one or more types of sesamin may preferably use sesamin and/or episesamin, more preferably use sesamin and episesamin, or episesamin, and even more preferably use episesamin . When using sesamin and episesamin, these ratios are not particularly limited. For example, sesamin: episesamin (weight ratio) is preferably 1:0.1 to 1:9, more preferably 1:0.3 to 1:3, More preferably, it is 1:0.5 to 1:2.

The sesamin used in the present invention is not subject to any restriction on its form or production method. For example, in the case of sesamin, sesamin extracted from sesame oil (referred to as a sesamin extract or purified product) by a known method (for example, the method described in Japanese Patent Application Laid-Open No. 4-9331) can be used. Moreover, you may use a commercially available sesame oil (liquid form) as it is. However, when sesame oil is used, it is possible to be evaluated as the characteristic flavor of sesame oil as poor sensory; therefore, it is advisable to use a tasteless and odorless sesamin extract (or purified sesamin) extracted from sesame oil. In addition, when sesame oil is used, since the content of sesamin is low, if a suitable amount of sesamin is to be mixed, the volume per unit of the formulated composition will become too large, which may cause ingestion problems. In particular, when the formulation is formed into oral administration, the formulation (tablet, capsule, etc.) is too large and ingestion problems occur. Therefore, it is also preferable to use a sesamin extract (or a purified sesamin) derived from sesame oil from the viewpoint that the intake can be reduced. In the present invention, one or more kinds of sesamins that have been purified or separated can also be used. Sesamins can also be obtained by synthesis. As the method, for example, sesamin and episesamin can be synthesized by the method of Beroza et al. (J. Am. Chem. Soc., 78, 1242 (1956)). The metabolites of sesamin and episesamin can be synthesized by the method of Urata et al. (Chem. Pharm. Bull. (Tokyo), 56 (11) 1611-2 (2008)).

Sesamin is a compound that is contained in natural products or food and drink and has edible experience. Therefore, based on the safety point of view, it has been determined that sesamin is not too problematic even if it is taken daily, for example. According to the present invention, it is possible to provide a composition for maintaining, preventing, suppressing, or improving the amount of living activity containing a highly safe substance as an active ingredient.

The composition of the present invention can be applied to either therapeutic use (medical use) or non-therapeutic use (non-medical use). Non-treatment refers to the concept that does not include medical behavior, that is, the operation, treatment, or diagnosis of the human body. The composition of the present invention can be made into the form of food and drink, medicine, quasi-drug, feed, etc. The composition of the present invention can be used for the maintenance, prevention of decrease, suppression of decrease or improvement of the diet, medicine, quasi-drug, feed, etc., or it can be used as a blending with these items. Materials or preparations, etc. The composition of the present invention can be provided in the form of a preparation for one example, but is not limited to this form. The preparation can also be provided directly as a composition or as a composition containing the preparation. The composition of the present invention may be any of a composition for oral administration and a composition for parenteral administration, and is preferably a composition for oral administration. Examples of the composition for oral administration include food and beverages, oral pharmaceuticals, quasi-drugs, and feeds, preferably foods and beverages or oral pharmaceuticals, and more preferably foods and beverages.

As long as the composition of the present invention does not impair the effects of the present invention, in addition to one or more types of sesamin, any additives and optional components may be contained. These additives and components can be selected according to the form of the composition, etc., and can be used generally for foods, beverages, pharmaceuticals, quasi-drugs, feeds, and the like. When the composition of the present invention is intended to be made into food, drink, medicine, quasi-drug, feed, etc., the production method is not particularly limited, and it can be produced by a general method.

For example, when the composition of the present invention is intended to be made into food and beverage products, one or more sesamin-based ingredients (such as food materials, food additives to be used according to needs, etc.) can be blended with ingredients that can be used in food and beverage products. Into a variety of food and beverages. Foods and beverages are not particularly limited, and examples thereof include general foods and beverages, health foods, supplementary health foods, health drinks, functional foods, foods for specific health use, foods for patients, and the like. The above-mentioned health foods, health supplement foods, functional foods, foods for specific health use, etc. can be, for example, fine granules, lozenges, granules, powders, capsules, chewing lozenges, dry syrups, syrups, liquids, and beverages. , Liquid food and other preparation forms.

When the composition of the present invention is intended to be made into a pharmaceutical or quasi-drug, for example, one or more sesamin compounds can be blended with pharmacologically acceptable carriers, additives added as required, etc., to form various agents Shaped medicines or quasi-drugs. Such carriers, additives, etc. may be pharmacologically acceptable as long as they can be used in pharmaceuticals or quasi-drugs, and examples include excipients, binders, disintegrants, lubricants, antioxidants, and colorants. One kind or two or more kinds. The form of administration (ingestion) of pharmaceuticals or quasi-drugs includes oral or parenteral (transdermal, transmucosal, enteral, injection, etc.) administration forms. When the composition of the present invention is intended to be made into a medicine or a quasi-drug, it is preferably made into a medicine or a quasi-drug for oral administration. The dosage form for oral administration includes liquid, lozenge, powder, fine granule, granule, dragee, capsule, suspension, emulsion, chewable lozenge and the like. The medicine can also be a medicine for non-human animals.

When the composition of the present invention is intended to be used as feed, it is only necessary to blend one or more kinds of sesamin in the feed. The feed also contains feed additives. The feed may include, for example, domestic animal feed for cattle, pigs, chickens, sheep, horses, etc.; feed for small animals such as rabbits, rats, mice, etc.; pet food for dogs, cats, and birds.

The content of sesamins contained in the composition of the present invention is not particularly limited, and can be set according to the form and the like. The total content of sesamin in the composition of the present invention, for example, is preferably 0.001% by weight or more in the composition, more preferably 0.01% by weight or more, still more preferably 0.05% by weight or more; and more preferably 10 % By weight or less, more preferably 5% by weight or less. In the same state, the total content of sesamin in the composition is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, and still more preferably 0.05 to 5% by weight. The above total content, if two or more sesamin compounds are contained, is their total content.

The composition of the present invention is preferably taken orally (orally administered). The dosage of the composition of the present invention (also called the intake amount) is not particularly limited. The dosage of the composition of the present invention may be such an amount as to obtain the effect of maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity, and it may be appropriately set according to the dosage form, the method of administration, the weight of the subject, etc. That's it.

In the same state, when humans (adults) are taken orally to ingest or administer the composition of the present invention, the total dosage of sesamin is based on 60 kg of body weight per day, preferably 0.5 mg or more, More preferably, it is 1 mg or more, still more preferably 3 mg or more; more preferably, it is 200 mg or less, more preferably 100 mg or less, and still more preferably 80 mg or less. In the same state, the total dosage of sesamin, if it is a human (adult), is based on a daily weight of 60 kg, preferably 0.5 to 200 mg, more preferably 1 to 100 mg, and even more preferably 3 to 80 mg . It is preferable to divide the above-mentioned amount into one or more times a day, for example, once or several times a day (for example, 2 to 3 times) to be ingested or administered. In the same state, it is preferable to allow humans to orally ingest or to administer the above-mentioned amount of sesamin. In the same state, the composition of the present invention can be used to allow humans to ingest or administer the above-mentioned amount of sesamin at a daily weight of 60 kg per day. The above-mentioned total dosage, if two or more sesamin compounds are used, is their total amount. In the same state, it is preferable to allow humans (adults) to take orally or administer the total dosage of sesamin and episesamin, based on 60 kg of body weight per day, preferably 0.5 to 200 mg, more preferably 1 to 100 mg, more preferably 3 to 80 mg of sesamin and/or episesamin.

The composition of the present invention is preferably continuously ingested or administered. Sesamin can be expected to improve the above-mentioned effects through continuous ingestion or administration. In the same state, it is preferable that the composition of the present invention is continuously ingested or administered for more than 1 week, more preferably more than 4 weeks, still more preferably more than 8 weeks, particularly preferably more than 12 weeks.

The subject to which the composition of the present invention is ingested or administered (also referred to as the subject of administration) is not particularly limited, and can be ingested by humans and animals other than humans. Examples of animals other than humans include economic animals, pets, and laboratory animals. Specifically, economic animals refer to livestock such as cattle, horses, pigs, goats and sheep, poultry such as chickens, ducks, Japanese quail, turkeys, and ostriches, as well as yellowtail, trevally, red sea bream, horse mackerel, carp, etc. Rainbow trout, eels and other fishes have industrial needs for raising animals. Pets refer to so-called play animals and companion animals such as dogs, cats, marmosets, birds, and hamsters; experimental animals refer to mice, rats, guinea pigs, beagles, mini pigs, common macaques, and crab-eating macaques. Animals for research in the fields of biology, agronomy and pharmacy.

The subject of administration of the composition of the present invention is preferably humans or non-human mammals, and more preferably humans. In the same state, the subjects of administration include those who need or desire maintenance of living activity level, prevention of reduction, suppression of reduction, or improvement. Such subjects may include, for example, middle-aged and elderly people, subjects who need or desire the maintenance, prevention, reduction, suppression, or improvement of the amount of life activity and/or life activity time, subjects who are aware of decreased vitality or energy in carrying out life activities, etc. . The middle-aged person may be, for example, a person over 40 years old. The middle-aged person includes the concept of the senior person. In the same state, among the middle-aged and elderly, the target is preferably the elderly. The elderly may be, for example, people over 60 years old or over 65 years old. The composition of the present invention can also be used for healthy persons for the purpose of preventing, for example, preventing or improving symptoms or diseases that are expected to be prevented or improved by the maintenance of living activity level and/or living activity time, prevention of reduction, suppression of reduction or improvement.

The composition of the present invention is attached with a mark of the function exerted by the maintenance, prevention of decrease, suppression of decrease or improvement of life activity amount and/or life activity time. As such a mark, you can add, for example, the choice of "maintain or increase the amount of life activity that decreases with age", "maintain or extend the time of life activity that decreases with age", "inhibit, prevent, shorten or improve Increase in inactive time with age", "maintain or increase the amount of living activities such as walking in daily life", "maintain or increase the amount of life activities such as leisure or work activities, etc.", " One or more function indications in the group consisting of "supporting active life", "inhibiting the decrease in the ability of daily living, preventing the decrease, maintaining, improving or enhancing the ability of daily living" and "maintaining independent living activities" . In the same aspect of the present invention, the composition of the present invention is preferably a food or beverage with the above-mentioned label. In addition, the above-mentioned mark may be used for the purpose of obtaining the above-mentioned function.

The present invention also includes the following methods: A method for maintaining, preventing, inhibiting, or improving the amount of life activity and/or life activity time, which is to administer one or more of sesamin.

The present invention also includes the following uses: The use of one or more types of sesamin is used to maintain, prevent decrease, suppress decrease or improve life activity amount and/or life activity time. The above methods and uses can be therapeutic methods or uses, or non-therapeutic methods or uses. By administering one or more kinds of sesamin to a subject, the maintenance, prevention of decrease, suppression of decrease or improvement of life activity amount and/or life activity time can be achieved.

In the above method and use, the sesamins and their preferred aspects are the same as the above-mentioned composition of the present invention. As one or more types of sesamin compounds, one type of sesamin compounds may be used, or two or more types may be used. In the above-mentioned method and use, it is preferable to administer (ingest) one or more sesamins to the subject once or more once a day, for example, once to several times a day (for example, 2 to 3 times). In the above methods and uses, it is preferable to administer (ingest) sesamin orally. The above-mentioned use is preferably for humans or non-human mammals, and more preferably for humans.

In the above method and use, it is sufficient to use one or more kinds of sesamin in an amount (also called an effective amount) that can obtain the desired effect. The preferred dosage or target of the sesamin is the same as the above-mentioned composition of the present invention. Sesamin can be administered directly or in a composition containing it. For example, the composition of the present invention described above can be used.

The present invention also includes the use of more than one type of sesamin, which is used to manufacture the composition of the present invention. In addition, all academic documents and patent documents described in this specification are included in this specification for reference. [Example]

Hereinafter, the present invention will be explained more specifically based on examples. A series of animal experiments comply with the Japanese Animal Care and Management Act and other related laws and regulations, and are implemented based on the plan approved by the agency chief after review by the animal experiment committee in the society. In addition, the present invention is not limited to these embodiments.

<Example 1: The effect of the sesamin/episesamin mixture (1:1) on inhibiting the decrease in the amount of living activity (in vivo test)> In this experiment, it was carried out under the condition of no exercise load, so all the activities measured by the study are equivalent to the so-called living activities of human beings. The general feed group and the feed group containing sesamin and episesamin are divided into groups in a way that the amount of living activity is equal. The measurement of the amount of living activity uses an accelerometer nanotag (manufactured by KISSEI COMTEC Co., Ltd.). For a 14-month-old Slc: SD male rat, under isoflurane anesthesia, an accelerometer was implanted under the skin of the neck, and after confirming recovery, the amount of activity during the active period (light-off time) was measured for 3 days. For the measurement of the amount of living activity, the number of vibrations above a certain intensity is continuously measured, and the total number of vibrations is used as the amount of living activity. This is divided into general feed (AIN-93M, manufactured by CLEA Japan) or feed containing 0.1% by weight of sesamin and episesamin mixture (sesamin: episesamin (weight ratio) = 1:1) The group of (test food) (each 8 animals/group) was allowed to take each feed (test food) for 8 months. The group that consumes general feed is called the general feed group for the elderly (general feed group), and the group that consumes the feed containing 0.1% by weight of sesamin and episesamin is called the feed group containing sesamin and episesamin for the elderly (contains sesamin and episesamin). Table sesamin feed group). In addition, the feed containing sesamin and episesamin, in which the total content of sesamin and episesamin is 0.1% by weight, is a mixture of sesamin and episesamin (sesamin: episesamin (weight ratio) )=1: 1). The life activity level during the active period was measured at the time points of 17 months and 22 months old for 1 week. In order to grasp the animal's health status, the food intake and body weight were measured regularly; rats that were judged to be difficult to continue the test were given appropriate euthanasia and excluded from the analysis. The final analysis targets are 4 old-age general feed groups and 6 old-age feed groups containing sesamin and episesamin.

Fig. 1 shows the change in the relative amount of living activity when the amount of living activity before the start of the test food is set to 1. In the graph of Figure 1, ● is the general feed group for the elderly, and ▲ is the feed group containing sesamin and episesamin for the elderly (*: p<0.05, compared to the general feed group for the elderly, repeated measures two-way ANOVA) . The lower the displayed value, the lower the activity. As shown in Figure 1, for the general feed group, the amount of life activity decreases with age. On the other hand, the feed group containing sesamin and episesamin can inhibit the decrease in the amount of living activity associated with aging. As a result of repeated analysis, an interaction can be seen between the test food and time ( p=0.014). At 22 months of age, compared with the general feed group, the living activity of the feed group containing sesamin and episesamin was significantly higher (Bonferoni test, p=0.023).

<Example 2: The effect of inhibiting the decrease in living activity level by administering sesamin or episesamin alone (in vivo test)> Example 2 is a test for exploring which of sesamin or episesamin is more helpful in inhibiting the decrease in life activity. The basic operation is implemented in accordance with Example 1. The 14-month-old Slc: SD male rats are divided into general feed (CE-2, manufactured by CLEA Japan Co., Ltd.) or feed containing 0.1% sesamin or episesamin in a way that equalizes their activity levels. Groups (3 animals/group) were allowed to take each feed (test food) for 1 month. The life activity level during the active period was measured at the 16-month-old time point after 1 month of ingestion of the test food. The final analysis targets are 2 general feed groups, 3 sesamin-containing feed groups, and 3 episesamin-containing feed groups. Table 1 shows the amount of living activity of each group after taking the test food for 1 month when the amount of living activity before the start of the test food is set to 1 hour. The lower the value, the lower the amount of life activity. As shown in Table 1, for the general feed group, the amount of living activity decreased. On the other hand, the feed group containing sesamin and the feed group containing episesamin, compared with the general feed group, can suppress the decrease in the amount of life activity caused by aging. Regarding the feed group containing episesamin, no reduction in the amount of life activity due to age increase is seen.

The above indirectly indicates that sesamin and episesamin can inhibit the decrease in life activity caused by aging, and can maintain life activity, prevent the decrease in life activity, inhibit the decrease in life activity, or improve life activity; it is obvious that The effect is stronger with episesamin.

[Figure 1] is a graph showing the effect of sesamin and episesamin mixture (sesamin: episesamin (weight ratio=1:1)) on the amount of living activity.

Claims (9)

A composition for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity, which contains one or more kinds of sesamin. Such as the composition of claim 1, wherein one or more kinds of sesamin are sesamin and/or episesamin. Such as the composition of claim 1 or 2, wherein one or more of sesamin is episesamin. Such as the composition of any one of claims 1 to 3, which is used to prevent or suppress the decrease in the amount of living activity that accompanies aging, improve the amount of living activity that accompanies aging, and prevent or suppress the decline in life activity that accompanies aging. The increase in the inactive time of life, the improvement of the inactive time that increases with age. The composition according to any one of claims 1 to 4 is a composition for oral administration. Such as the composition of claim 5, wherein the aforementioned composition for oral administration is a food or drink, a medicine, a quasi-drug, or a feed. Such as the composition of claim 6, wherein the aforementioned foods and beverages are foods for specific health use, foods with nutritional functions, or foods with functional labeling. A method for maintaining, preventing decrease, suppressing decrease, or improving the amount of living activity, which is to administer more than one type of sesamin. The use of one or more kinds of sesamins is used to maintain, prevent decrease, inhibit decrease or improve the amount of living activity.

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