TW202120676A - Microorganism or biomolecule collecting system and method thereof for environment - Google Patents

Abstract

A microorganism or biomolecule collecting method includes: combining a plurality of magnetic beads with a magnetically attractable carrier to form a magnetic bead-attached carrier; arranging the magnetically attractable carrier and magnetic beads thereof in an environment to collect a plurality of microorganism or biomolecule samples to form a plurality of microorganism or biomolecule-binding beads; releasing the plurality of microorganism or biomolecule-binding beads from the magnetically attractable carrier; and extracting the plurality of microorganism or biomolecule samples from the plurality of microorganism or biomolecule-binding beads.

Description

System and method for collecting microorganisms or biomolecules in environment

The present invention relates to a collection system and method for microorganisms or biomolecules in an environment; in particular, it relates to a collection system and methods for microorganisms or biomolecules in a portable environment.

For example, the conventional magnetic bead-type specimen separation technology and device, such as the invention patent of "magnetic bead-type specimen separation device" of the Republic of China Patent Publication No. TW-I296713, which discloses a magnetic bead-type specimen separation device . The magnetic bead sample separation device includes a body, a first reaction tank, a second reaction tank, a third reaction tank, a first micro flow channel and a second micro flow channel. The first reaction tank, the second reaction tank, the third reaction tank, the first micro flow channel and the second micro flow channel are arranged in the body.

In addition, the aforementioned No. TW-I296713 injects a mixed solution into the first reaction tank, and the mixed solution contains a plurality of magnetic beads and a sample extract, and the sample extract is bound to the magnetic beads. Inject a washing buffer [washing buffer] into the second reaction tank, and inject a separation buffer [elution buffer] into the third reaction tank and the third reaction tank, and the second reaction tank is located in the first reaction tank and Between the third reaction tank. The first micro flow channel is connected to the first reaction tank and the second reaction tank, and the second micro flow channel is connected to the second reaction tank and the third reaction tank.

In addition, the magnetic beads of No. TW-I296713 mentioned above are driven by a magnetic force to move from the first reaction tank to the second reaction chamber via the first microfluidic channel. Should be grooved so that the washing buffer cleans the magnetic beads. The magnetic beads are then driven by the magnetic force to move from the second reaction tank to the third reaction tank via the second microfluidic channel, so that the separation buffer can separate the magnetic beads and the sample extract.

However, the structure of the main body, the first reaction tank, the second reaction tank, the third reaction tank, the first micro flow channel and the second micro flow channel of the magnetic bead sample separation device of No. TW-I296713 is only simple It is only suitable for general magnetic bead sample separation technology, so it is not suitable for the collection technology of microorganisms or biomolecules in the environment.

Another conventional test-tube micro-magnetic bead immobilization technology and device for biomolecule experiments, such as the new patent of "test-tube micro-magnetic bead fixing device" in the Republic of China Patent Publication No. TW-M536587, which discloses a test-tube micro-magnetic bead Fixtures. The test tube type micro-magnetic bead fixing device includes an upper seat, a lower seat, a middle column, a ring magnet and two rings.

In addition, the upper base of No. TW-M536587 mentioned above is in the shape of a disc, and the outer ring of the upper base is provided with a plurality of fixing holes, and the fixing holes penetrate the upper base, and the fixing holes can be inserted separately A test tube, and an upper seat groove is provided on the bottom surface of the upper seat.

In addition, the lower seat of No. TW-M536587 mentioned above is in the shape of a disc, and the outer ring of the lower seat is provided with a plurality of fixing grooves, and the fixing hole corresponds to the fixing groove, and a plurality of the fixing grooves are available for The test tubes after being inserted are pressed against each other, and the top surface of the lower seat is provided with a lower seat groove, and the upper seat groove corresponds to the lower seat groove.

On the other hand, the center column of the aforementioned No. TW-M536587 is set between the upper seat and the lower seat, and the upper and lower end surfaces of the center column abut against the groove of the upper seat and the groove of the lower seat, respectively. The ring magnet is sleeved on the center column, and the two loops are sleeved on the center column, and are respectively located between the upper seat and the ring magnet, and between the lower seat and the ring magnet.

However, the structure of the upper seat, lower seat, center post, ring magnet and ring of the test tube type micro-magnetic bead fixing device of No. TW-M536587 mentioned above The manufacturing is only suitable for general biomolecule experiments with test-tube micro-magnetic beads immobilization technology, so it is not suitable for microbes or biomolecule collection technology in the environment.

Another conventional magnetic bead sample nucleic acid extraction technology and equipment, such as the new patent of "Magnetic Bead Nucleic Acid Extraction Equipment" in the Republic of China Patent Publication No. TW-M445583, which discloses a magnetic bead nucleic acid extraction equipment. The magnetic bead nucleic acid extraction equipment includes a first test tube cassette, a magnetic bead sample purification device, a detection test tube, and a detection device.

In addition, the first test tube cassette of the aforementioned No. TW-M445583 has a plurality of test tubes, and the test tubes are arranged adjacently, and the test tube is used for accommodating a plurality of magnetic beads and at least one specimen. The magnetic bead type specimen purification device is used to perform a separation process and an extraction process on the specimen. The magnetic bead type sample purification device includes a frame and a magnetic control device, and the frame carries the first test tube cassette, and the magnetic control device provides a magnetic force to drive the magnetic beads to move for the extraction process to obtain One extract.

In addition, the aforementioned detection test tube No. TW-M445583 is used to contain the extract, and the detection device includes an accommodating space, an ultraviolet light source and a sensing unit, and the accommodating space accommodates the extract Detection test tube. The ultraviolet light source outputs a light beam, and the light beam has a plurality of different wavelengths of ultraviolet light, and the light beam is projected to the detection test tube, and the sensing unit is arranged on the traveling path of the light beam to receive and pass the detection The beam of the extract in the test tube.

However, the structure of the first test tube cassette, magnetic bead sample purification device, detection test tube and detection device of the magnetic bead type nucleic acid extraction equipment of No. TW-M445583 mentioned above is only suitable for general biomolecule experiments. The microbead fixation technology is only, so it is not suitable for the collection technology of microorganisms or biomolecules in the environment.

Obviously, the aforementioned magnetic bead sample separation device No. TW-I296713 and the test tube type micro-magnetic bead fixing device No. TW-M536587 The magnetic bead-type nucleic acid extraction equipment with No. TW-M445583 must have a potential demand for further improvement of its overall technology.

The aforementioned inventions or new patents of Republic of China Patent No. TW-I296713, Announcement No. TW-M536587 and Announcement No. TW-M536587 are only a reference for the technical background of the present invention and illustrate the current state of technology development, and they are not intended to limit The scope of the invention.

In view of this, in order to meet the above-mentioned needs, the present invention provides a system and method for collecting microorganisms or biomolecules in the environment, which utilizes a magnetically attractable carrier to configure several magnetic beads to form a magnetic bead adsorption carrier, and the The magnetically attractable carrier and its magnetic beads are placed in an environment to collect samples of several microorganisms or biomolecules to form several microorganisms or biomolecules adsorbed magnetic beads, and several microorganisms or biomolecules are adsorbed from the magnetically attractable magnetic beads. The carrier is unloaded, and several microbes or biomolecule samples are subsequently taken out from several microbes or biomolecule adsorption magnetic beads, so as to improve the technical problems of microbes or biomolecule collection in the conventional environment.

The main purpose of the preferred embodiments of the present invention is to provide a system and method for collecting microorganisms or biomolecules in the environment, which utilizes a magnetically attractable carrier to configure a plurality of magnetic beads to form a magnetic bead adsorption carrier, and the magnetically attractable carrier The suction carrier and its magnetic beads are placed in an environment to collect several samples of microorganisms or biomolecules to form several microbes or biomolecules adsorbed magnetic beads, and several microbes or biomolecules adsorbed magnetic beads are unloaded from the magnetically attractable carrier Next, and then take out several samples of the microorganisms or biomolecules from the microbes or biomolecule adsorption magnetic beads, so as to achieve the purpose of collecting microorganisms or biomolecules from the environment.

In order to achieve the above objectives, the system for collecting microorganisms or biomolecules in the environment of a preferred embodiment of the present invention includes:

At least one magnetically attractable carrier, which has a magnetically attractable area; and

Several first magnetic beads, which are arranged on the magnetically attractable carrier Attracting area to form a first magnetic bead adsorption carrier;

The magnetically attractable carrier and its first magnetic beads are placed in an environment to collect samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecules adsorbed magnetic beads, and a plurality of the first microorganisms or The biomolecule adsorption magnetic beads are unloaded from the magnetically attractable carrier, and a plurality of the microorganisms or biomolecule samples are subsequently taken out from the plurality of the first microorganisms or the biomolecule adsorption magnetic beads.

In another preferred embodiment of the present invention, the system for collecting microorganisms or biomolecules in the environment includes:

At least one magnetically attractable carrier, which has a first magnetically attractable area and a second magnetically attractable area;

A plurality of first magnetic beads arranged in the first magnetically attractable area of the magnetically attractable carrier; and

A plurality of second magnetic beads arranged in the second magnetically attractable area of the magnetically attractable carrier, so that the first magnetic beads and the second magnetic beads form a first magnetic bead and a second magnetic bead adsorption carrier;

The magnetically attractable carrier, its first magnetic beads and its second magnetic beads are placed in an environment to collect several samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecule adsorption magnetic beads and a plurality of second magnetic beads. Two microorganisms or biomolecules adsorb the magnetic beads, and a plurality of the first microorganisms or biomolecules adsorbed magnetic beads and a plurality of the second microorganisms or biomolecules adsorbed magnetic beads are removed from the magnetically attractable carrier, and from the plurality of the magnetic beads The first microbe or biomolecule adsorption magnetic beads and a plurality of the second microbes or biomolecule adsorption magnetic beads are subsequently taken out of a plurality of samples of the microbes or biomolecules.

The magnetically attractable carrier of the preferred embodiment of the present invention is selected from a rod, a sheet, a sphere, an ellipsoid, a block, or any combination thereof.

In a preferred embodiment of the present invention, the first magnetic bead or the second magnetic bead is selected from a magnetic bead with a chemically modified surface.

The surface of the first magnetic bead or the second magnetic bead in the preferred embodiment of the present invention can adsorb different microorganisms or biological molecules.

In order to achieve the above objective, the method for collecting microorganisms or biomolecules in the environment of a preferred embodiment of the present invention includes:

Use a magnetically attractable carrier to configure a plurality of first magnetic beads to form a first magnetic bead adsorption carrier;

Placing the magnetically attractable carrier and its first magnetic beads in an environment to collect several samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecules adsorbing magnetic beads;

Removing a plurality of the first microbe or biomolecule adsorbed magnetic beads from the magnetically attractable carrier; and

A plurality of samples of the microorganisms or biomolecules are subsequently taken out from a plurality of the first microorganisms or biomolecule adsorption magnetic beads.

The method for collecting microorganisms or biomolecules in the environment according to another preferred embodiment of the present invention includes:

Using a magnetically attractable carrier to configure a plurality of first magnetic beads and a plurality of second magnetic beads, so that the first magnetic beads and the second magnetic beads form a first magnetic bead and a second magnetic bead adsorption carrier;

The magnetically attractable carrier, its first magnetic beads and its second magnetic beads are placed in an environment to collect samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecule adsorption magnetic beads and a plurality of second magnetic beads. Microbe or biomolecule adsorption magnetic beads;

Removing a plurality of the first microbe or biomolecule adsorption magnetic beads and a plurality of the second microbe or biomolecule adsorption magnetic beads from the magnetically attractable carrier; and

A plurality of samples of the microorganisms or biomolecules are subsequently taken out from a plurality of the first microorganisms or biomolecules adsorbed magnetic beads and a plurality of the second microorganisms or biomolecules adsorbed magnetic beads.

The magnetically attractable carrier of the preferred embodiment of the present invention is selected from a rod Body, one piece, one sphere, one ellipsoid, one piece or any combination thereof.

In a preferred embodiment of the present invention, the first magnetic bead or the second magnetic bead is selected from a magnetic bead with a chemically modified surface.

The surface of the first magnetic bead or the second magnetic bead in the preferred embodiment of the present invention can adsorb different microorganisms or biological molecules.

1‧‧‧Magnetic-attractable carrier

10‧‧‧Magnetic area

1a‧‧‧Magnetic-attractable carrier

11‧‧‧The first magnetically attractable area

12‧‧‧Second magnetically attractable area

2‧‧‧Magnetic beads

2a‧‧‧The first magnetic bead

2b‧‧‧Second magnetic bead

3‧‧‧DNA

Figure 1: A schematic diagram of the collection system for microorganisms or biomolecules in the environment according to the first preferred embodiment of the present invention.

Figure 2: The flow block diagram of the method for collecting microorganisms or biomolecules in the environment according to the first preferred embodiment of the present invention.

Figure 3: A schematic diagram of the collection system of microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention.

Figure 4: A flow block diagram of a method for collecting microorganisms or biomolecules in an environment according to a second preferred embodiment of the present invention.

In order to fully understand the present invention, preferred embodiments are exemplified below and described in detail with the accompanying drawings, and they are not intended to limit the present invention.

First of all, the system and method for collecting microorganisms or biomolecules in the environment of the preferred embodiment of the present invention can be applied to various water areas (for example: freshwater waters, estuarine waters, intertidal zones or ocean waters) or ecosystems for collecting microorganisms or biomolecules. Or water quality inspection operations, various aquatic (or marine) biological seedling breeding industry or related aquatic (or marine) biological seedling industry, but it is not used to limit the scope of application of the present invention.

For example, the collection system and method for microorganisms or biomolecules in the environment of the preferred embodiment of the present invention adopts the technical term "microorganism" to define viruses, bacteria, fungus, or other microorganisms; the present invention The microorganisms or organisms in the environment of the preferred embodiment The molecular collection system and its method use the technical term "biomolecule" to define DNA, RNA, protein or other biological molecules, such as biological macromolecules, but it is not intended to limit the scope of application of the present invention.

Fig. 1 shows a schematic diagram of the collection system of microorganisms or biomolecules in the environment according to the first preferred embodiment of the present invention. Please refer to Figure 1. For example, the collection system for microorganisms or biomolecules in the environment of the first preferred embodiment of the present invention includes at least one or several magnetically attractable carriers 1 and several magnetic carriers. Magnetic beads 2 to form a portable collection system for microorganisms or biomolecules, and optionally include a magnetic bead removal device (not shown), a sample dissolution device (not shown) or a similar function的装置。 The device.

Please refer to Figure 1 again. For example, the magnetically attractable carrier 1 has at least one or more magnetically attractable regions 10, and at least one or more of the magnetically attractable regions 10 corresponds to a plurality of the magnetic beads. 2. The magnetically attractable carrier 1 of another preferred embodiment of the present invention is selected from a rod, a piece, a sphere, an ellipsoid (football), a block, an object of any geometric shape, or any combination thereof.

Please refer to FIG. 1 again. For example, the magnetic beads 2 can be appropriately adsorbed and arranged in the magnetically attractable area 10 of the magnetically attractable carrier 1. In addition, the magnetic bead 2 is selected to be made of a suitable material (for example: ferroferric oxide or other magnetic materials), and the magnetic bead 2 is selected to have a diameter of a suitable size and size, and the magnetic bead 2 has a suitable appearance shape, for example: Irregular surface.

Please refer to Figure 1 again. For example, the magnetic bead 2 [shown in the schematic frame of Figure 1] can be selected from a magnetic bead with a chemically modified surface, and the chemically modified surface of the magnetic bead 2 is appropriately selected It has various functional groups, such as amino, carboxyl or hydroxyl. In this way, the surface of the magnetic beads 2 can adsorb different microorganisms or biomolecules, but it is not used to limit the scope of application of the present invention.

Figure 2 discloses the microenvironment of the first preferred embodiment of the present invention The flow block diagram of the biological or biomolecule collection method corresponds to the microbes or biomolecule collection system in the environment of Figure 1. Please refer to Figures 1 and 2, the method for collecting microorganisms or biomolecules in the environment according to the first preferred embodiment of the present invention includes step S1: First, for example, using appropriate technical means (such as magnetic attraction) The magnetically attractable area 10 of the magnetically attractable carrier 1 is configured with a plurality of the magnetic beads 2 to form a magnetic bead adsorption carrier (that is, the magnetic bead has adsorbed carrier).

Please refer to Figures 1 and 2, the method for collecting microorganisms or biomolecules in the environment of the first preferred embodiment of the present invention includes step S2: Then, for example, the magnetically attractable carrier 1 and its magnetic beads 2 Collect several microorganisms or biomolecule samples in an environment (for example, microorganism or biomolecule sampling operation environment) by appropriate technical means to form several microorganisms or biomolecule adsorption magnetic beads.

Please refer to Figures 1 and 2 again. The method for collecting microorganisms or biomolecules in the environment of the first preferred embodiment of the present invention includes step S3: Then, for example, a plurality of the microorganisms or biomolecules are adsorbed to magnetic beads. Appropriate technical means (e.g., using a magnetic base removal device or a magnetic ring removal device for magnetic operation) are released from the magnetically attractable area 10 of the magnetically attractable carrier 1 (releasing).

Please refer to Figures 1 and 2 again. The method for collecting microorganisms or biomolecules in the environment of the first preferred embodiment of the present invention includes step S4: Then, for example, by appropriate technical means (such as: using a lysis solution, washing Liquid and return solution method] A plurality of microbes or biomolecule samples are subsequently taken out from a plurality of the first microorganisms or biomolecule adsorption magnetic beads.

Please refer to Figures 1 and 2, the method for collecting microorganisms or biomolecules in the environment of the first preferred embodiment of the present invention can choose to use a magnetic bead removal tube, a magnetic bead removal bucket, and a magnetic bead removal method. The chamber or any combination thereof, and it can be selected from an automatic device, a semi-automatic device or a manual device.

Fig. 3 shows a schematic diagram of the collection system of microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention. Please refer to Figure 3. For example, compared to the first embodiment, the system for collecting microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention includes a magnetically attractable carrier 1a and a plurality of first magnetic beads 2a and several second magnetic beads 2b to form a portable microorganism or biomolecule collection system.

Please refer to Figure 3 again. For example, the magnetically attractable carrier 1a has at least one or more first magnetically attractable regions 11 and at least one or more second magnetically attractable regions 12, and at least one or A plurality of the first magnetically attractable regions 11 corresponds to a plurality of the first magnetic beads 2a, and at least one or a plurality of the second magnetically attractable regions 12 corresponds to a plurality of the second magnetic beads 2b.

Please refer to Figure 3 again. For example, the surface of the first magnetic bead 2a and the second magnetic bead 2b of another preferred embodiment of the present invention can be selected to adsorb different microorganisms or biological molecules to form a A collection system for microorganisms or biomolecules in a compound environment.

Fig. 4 shows a flow block diagram of the method for collecting microorganisms or biomolecules in the environment according to the second preferred embodiment of the present invention, which corresponds to the system for collecting microorganisms or biomolecules in the environment of Fig. 3. Please refer to Figures 3 and 4, the method for collecting microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention includes step S1A: First, for example, the magnetically attractable carrier 1a is used by appropriate technical means. A magnetically attractable region 11 and a second magnetically attractable region 12 are configured with a plurality of the first magnetic beads 2a and a plurality of the second magnetic beads 2b, so that the first magnetic beads 2a and the second magnetic beads 2b form a first A magnetic bead and a second magnetic bead adsorption carrier, that is, a composite magnetic bead adsorption carrier.

Please refer to Figures 3 and 4 again. The method for collecting microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention includes step S2A: Then, for example, the magnetically attractable carrier 1a and the first magnetic The beads 2a and the second magnetic beads 2b are placed in an environment by appropriate technical means to collect several samples of microorganisms or biomolecules, so as to form several first microorganisms or biomolecule samples. Attached with magnetic beads and several second microorganisms or biomolecule adsorption magnetic beads.

Please refer to Figures 3 and 4 again. The method for collecting microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention includes step S3A: Then, for example, a plurality of the first microorganisms or biomolecules are adsorbed magnetically. The beads and a plurality of the second microbe or biomolecule adsorption magnetic beads are removed from the first magnetically attractable area 11 and the second magnetically attractable area 12 of the magnetically attractable carrier 1a by appropriate technical means.

Please refer to Figures 3 and 4 again. The method for collecting microorganisms or biomolecules in the environment of the second preferred embodiment of the present invention includes step S4A: Then, for example, using appropriate technical means to collect the first microorganisms or The biomolecule adsorption magnetic beads and a plurality of the second microorganisms or biomolecule adsorption magnetic beads are subsequently taken out of a plurality of samples of the microorganisms or biomolecules.

The foregoing preferred embodiments only illustrate the present invention and its technical features. The technology of this embodiment can still be implemented with various substantially equivalent modifications and/or alternatives; therefore, the scope of rights of the present invention shall be subject to a patent application. The scope defined by the scope shall prevail. The copyright in this case is restricted to the use of patent applications in the Republic of China.

1‧‧‧Magnetic-attractable carrier

10‧‧‧Magnetic area

2‧‧‧Magnetic beads

3‧‧‧DNA

Claims (10)

A collection system for microorganisms or biomolecules in the environment, which includes: At least one magnetically attractable carrier, which has a magnetically attractable area; and A plurality of first magnetic beads arranged in the magnetically attractable area of the magnetically attractable carrier to form a first magnetic bead adsorption carrier; The magnetically attractable carrier and its first magnetic beads are placed in an environment to collect samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecules adsorbed magnetic beads, and a plurality of the first microorganisms or The biomolecule adsorption magnetic beads are unloaded from the magnetically attractable carrier, and a plurality of the microorganisms or biomolecule samples are subsequently taken out from the plurality of the first microorganisms or the biomolecule adsorption magnetic beads. A collection system for microorganisms or biomolecules in the environment, which includes: At least one magnetically attractable carrier, which has a first magnetically attractable area and a second magnetically attractable area; A plurality of first magnetic beads arranged in the first magnetically attractable area of the magnetically attractable carrier; and A plurality of second magnetic beads arranged in the second magnetically attractable area of the magnetically attractable carrier, so that the first magnetic beads and the second magnetic beads form a first magnetic bead and a second magnetic bead adsorption carrier; The magnetically attractable carrier, its first magnetic beads and its second magnetic beads are placed in an environment to collect several samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecule adsorption magnetic beads and a plurality of second magnetic beads. Two microorganisms or biomolecules adsorb the magnetic beads, and a plurality of the first microorganisms or biomolecules adsorbed magnetic beads and a plurality of the second microorganisms or biomolecules adsorbed magnetic beads are removed from the magnetically attractable carrier, and from the plurality of the magnetic beads The first microbe or biomolecule adsorption magnetic beads and a plurality of the second microbes or biomolecule adsorption magnetic beads are subsequently taken out of a plurality of samples of the microbes or biomolecules. The collection system for microorganisms or biomolecules in the environment according to item 1 or 2 of the scope of patent application, wherein the magnetically attractable carrier is selected from a rod, a slice, a sphere, an ellipsoid, a block, or any combination thereof . According to the collection system for microorganisms or biomolecules in the environment described in item 1 or 2 of the scope of patent application, the first magnetic bead or the second magnetic bead is selected from a magnetic bead with a chemically modified surface. According to the collection system for microorganisms or biomolecules in the environment described in item 1 or 2 of the scope of patent application, the surface of the first magnetic bead or the second magnetic bead can adsorb different microorganisms or biomolecules. A method for collecting microorganisms or biomolecules in the environment, which comprises: Use a magnetically attractable carrier to configure a plurality of first magnetic beads to form a first magnetic bead adsorption carrier; Placing the magnetically attractable carrier and its first magnetic beads in an environment to collect several samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecules adsorbing magnetic beads; Removing a plurality of the first microbe or biomolecule adsorbed magnetic beads from the magnetically attractable carrier; and A plurality of samples of the microorganisms or biomolecules are subsequently taken out from a plurality of the first microorganisms or biomolecule adsorption magnetic beads. A method for collecting microorganisms or biomolecules in the environment, which comprises: Using a magnetically attractable carrier to configure a plurality of first magnetic beads and a plurality of second magnetic beads, so that the first magnetic beads and the second magnetic beads form a first magnetic bead and a second magnetic bead adsorption carrier; The magnetically attractable carrier, its first magnetic beads and its second magnetic beads are placed in an environment to collect samples of microorganisms or biomolecules to form a plurality of first microorganisms or biomolecule adsorption magnetic beads and a plurality of second magnetic beads. Microbe or biomolecule adsorption magnetic beads; Removing a plurality of the first microbe or biomolecule adsorption magnetic beads and a plurality of the second microbe or biomolecule adsorption magnetic beads from the magnetically attractable carrier; and A plurality of samples of the microorganisms or biomolecules are subsequently taken out from a plurality of the first microorganisms or biomolecules adsorbed magnetic beads and a plurality of the second microorganisms or biomolecules adsorbed magnetic beads. According to the microorganisms or organisms in the environment described in item 6 or 7 of the scope of patent application The method for collecting molecules, wherein the magnetically attractable carrier is selected from a rod, a sheet, a sphere, an ellipsoid, a block, or any combination thereof. According to the method for collecting microorganisms or biomolecules in the environment according to item 6 or 7 of the scope of patent application, the first magnetic bead or the second magnetic bead is selected from a magnetic bead with a chemically modified surface. According to the method for collecting microorganisms or biomolecules in the environment according to item 6 or 7 of the scope of patent application, the surface of the first magnetic bead or the second magnetic bead can adsorb different microorganisms or biomolecules.

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