TW202114521A - Flupyrimin-containing solid formulation for rice pest control - Google Patents

Abstract

Provided is a solid formulation for rice pest control, which is a coated granule or extruded granule and comprises at least one effective component selected from the group consisting of flupyrimin as represented by formula (1): and salts thereof, and also a solid carrier, a surfactant, and a binder.

Description

A solid preparation for controlling rice pests containing flupyrimine (flupyrimin)

The present invention relates to a solid preparation for controlling rice pests containing flupirazine, more specifically, it relates to a solid preparation for controlling rice pests of coated granules or extruded granules, and a method for controlling rice pests using the same, And the manufacturing method of the aforementioned solid preparation for controlling rice pests.

More than 90% of rice, the staple food of the Asian region, is produced in Asia. In particular, China, India, and Indonesia account for 60% of the world's production (Non-Patent Document 1). In rice cultivation (rice cultivation) in these areas, it has become a problem to reduce the yield due to ingestion damage to the above-ground Pterodactyl pests and damage to the hemipteran pests of the sap-sucking stems and leaves, especially Pterodactyls. Pests such as Chilo suppressalis, and planthoppers of Hemiptera pests cause great damage. The damage to rice production due to diseases and pests is as high as 45% (Non-Patent Document 2). In order to increase rice production, the control of these rice pests has become necessary.

At present, for these rice pests that occur in different periods, the effective pesticides are used separately or in combination to control the pests (system control). When multiple treatments are performed, the personnel costs related to the treatment of the pesticides are consumed. Or labor. In addition, the occurrence of pests with reduced susceptibility to existing drugs is a problem (Non-Patent Documents 3 and 4). Existing drugs such as organophosphorus, phenyl carbamate (Carbamate), and synthetic pyrethrins are not The use is restricted due to the adverse effects of non-target organisms. Accordingly, it is expected that the control activity has a wide range of versatility and a long duration, does not show cross-drug resistance with existing drugs, and has a low impact on the environment.

It has been reported that flurpyrazine is used as a pest control agent. It has insecticidal effect against hemipteran pests such as planthoppers and chilo suppressalis that occur on rice (Rice, etc.), or it has insecticidal effect against existing pesticides. It does not show cross drug resistance and has a low impact on the environment (Patent Document 1). It has also been reported to be used for the control of planthoppers, Chilo suppressalis, etc. It can be mixed with other insecticides or fungicides ( Patent Document 2). However, there are still insufficient researches on the specific formulation form or use method in the practical scene of rice production, especially the duration of the control activity. [Prior Technical Literature] [Patent Literature]

[Patent Document 1] International Publication No. 2012/029672 [Patent Document 2] International Publication No. 2013/129688 [Non-Patent Literature]

[Non-Patent Document 1] AMIS Market Database, retrieved on September 20, 2018, Internet, <URL: http://statistics.amis-outlook.org/data/ index.html> [Non-Patent Document 2] India Crop Protection Chemicals (Pesticides) Market-Growth, Trends and Forecast (2017-2022), Mordor Intelligence report (December 2017) [Non-Patent Document 3] Pest Management Science,Vol.73(6), 1169-1178(2017) [Non-Patent Document 4] Scientific Reports, (2018) 8: 4586|DOI: 10.1038/s41598-018-22906-5

[The problem to be solved by the invention]

The present invention was completed in view of such a situation, to provide a novel solid preparation for controlling pests, especially rice pests, with a very long duration of control activity, and a method for controlling rice pests using the same, and the foregoing The purpose is to produce a solid preparation for controlling rice pests. [Means to solve the problem]

When the inventors of the present invention made diligent research to solve the aforementioned problems, they found that as a solid preparation, at least one active ingredient selected from the group consisting of flupyrazine and its salts is combined with a specific solid carrier and interfacial activity. The compound and the binding agent become specific coated granules or extruded granules, which show excellent control activity against rice pests, and the aforementioned control activity lasts for a particularly long period of time, and the present invention is finally completed. That is, the present invention provides the following.

[1] A solid preparation for controlling rice pests, which contains at least one active ingredient selected from the group consisting of flupyrazine and its salts represented by the following formula (1), a solid carrier, a surfactant, and a combination Agent,

And for coated granules or extruded granules.

[2] The solid preparation for controlling rice pests as described in [1] is a coated granule, and the solid carrier includes core particles and an extender.

[3] The solid preparation for controlling rice pests as described in [2], wherein the particle diameter of the core particles is 63 μm to 6 mm.

[4] The solid preparation for controlling rice pests as described in [2] or [3], wherein the aforementioned nuclear particles are selected from the group consisting of silica sand, granular calcium carbonate, diatomaceous earth particles, granular clay, and pumice At least one of them.

[5] The solid preparation for controlling rice pests as described in any one of [2] to [4], wherein the extender is at least 1 selected from the group consisting of clay, calcium carbonate, kaolin and silica Kind.

[6] The solid formulation for controlling rice pests as described in any one of [2] to [5], wherein the aforementioned binding agent is selected from the group consisting of fluid paraffin, vegetable oil, polyethylene glycol, and polypropylene glycol At least one.

[7] The solid preparation for controlling rice pests as described in [1] is an extruded granule, the solid carrier includes an extender, and the surfactant includes a granulation improver and a collapse/dispersant.

[8] The solid formulation for controlling rice pests as described in [7], wherein the extender is at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silica, and bentonite.

[9] The solid formulation for controlling rice pests as described in [7] or [8], wherein the granulation improving agent is selected from the group consisting of sodium lauryl sulfate, sodium dialkylsulfosuccinate, and sodium alkylbenzene sulfonate At least 1 in the group.

[10] The solid formulation for controlling rice pests as described in any one of [7] to [9], wherein the aforementioned collapse and dispersing agent is selected from sodium lignosulfonate, calcium lignosulfonate, sodium naphthalenesulfonate Ermalin condensate, sodium polyacrylate, sodium polyoxyethylene alkyl ether sulfate, sodium polyoxyalkylene styrene phenyl ether sulfate, sodium polyoxyalkylene styrene phenyl ether phosphate, and polymerization of polyoxyethylene and polyoxypropylene At least one of the group consisting of sodium sulfate.

[11] The solid preparation for controlling rice pests as described in any one of [7] to [10], wherein the aforementioned binding agent is selected from polyvinyl alcohol, dextrin, sugars, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose. At least one of the group consisting of base cellulose and methyl cellulose.

[12] A method for controlling rice pests, which comprises applying an effective amount of the solid preparation for controlling rice pests as described in any one of [1] to [11] to a method selected from the group consisting of rice pests, rice, soil, and field water. At least one step in the group.

[13] The method for controlling rice pests as described in [12], wherein the aforementioned rice pests are selected from at least one of the group consisting of planthoppers and Chilo suppressalis.

[14] The method for controlling rice pests as described in [12] or [13], wherein the rice pests are pesticide-resistant pests.

[15] The method for controlling rice pests as described in any one of [12] to [14], wherein the effective amount of the solid preparation for controlling rice pests is 1 g to 1 kg per 10 ares of cultivated land.

[16] A method for manufacturing a solid preparation for controlling rice pests, which is the method for manufacturing a solid preparation for controlling rice pests as described in any one of [2] to [6], which is characterized by comprising: Adding the aforementioned binding agent, or the aforementioned binding agent and the aforementioned surfactant to the aforementioned core particles to make them wet to obtain the wetting step of wetting the core particles, and Mixing the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender, or the aforementioned active ingredient and the aforementioned extender and pulverizing to obtain the first mixing and pulverizing step of mixing and pulverizing, and The step of mixing the wet core particles and the first mixed and pulverized product to obtain a coated granule in which the surface of the wet core particles is coated with the first mixed and pulverized product.

[17] A method for manufacturing a solid preparation for controlling rice pests, which is the method for manufacturing a solid preparation for controlling rice pests as described in any one of [7] to [11], characterized in that it comprises: Mix the aforementioned active ingredient, the aforementioned extender, and the aforementioned binder and pulverize, or mix the aforementioned active ingredient, the aforementioned extender, and the aforementioned binder with the aforementioned granulation modifier and/or the aforementioned collapse/dispersant and pulverize, and The mixing and pulverizing step of obtaining the second mixed and pulverized product, and Kneading the second mixed and pulverized product and water, or kneading the second mixed and pulverized product and water with the aforementioned granulation modifier and/or the aforementioned collapse and dispersant to obtain a kneaded product, and The step of forming the aforementioned kneaded mixture with an extrusion granulator to obtain extruded granules. [Effects of the invention]

According to the present invention, it is possible to provide a novel solid preparation with a very long duration of the control activity for controlling harmful organisms, especially rice pests, and a method for controlling rice pests using the same, and the manufacture of the aforementioned solid preparation for controlling rice pests The method becomes possible.

In addition, flupyrazine and/or its salt (preferably an acid addition salt) does not show cross drug resistance with other drugs, is highly safe to non-target organisms, and exhibits sufficient and excellent control activity at low concentrations, However, according to the present invention, all of these can last particularly long periods of time. For example, by subjecting the solid preparation of the present invention containing the active ingredient fluorpyrazine and/or its acid addition salt to one treatment, it includes the Chilo suppressalis and Chilo suppressalis that occur at different times and cause great damage to rice. Two or more rice pests, such as planthoppers, can also be suppressed at low densities for a long period of time. Therefore, according to the present invention, it is expected that the yield of rice will be increased, and it will be able to solve the problems faced by existing chemicals that reduce the sensitivity to chemicals, the impact on the environment, the continuity of the effects, the effects on non-target organisms, and the reduction in labor of agricultural workers. Subject.

Hereinafter, the present invention will be described in detail based on its suitable embodiment.

＜Solid preparations＞ The present invention provides a solid preparation for the control of rice pests (hereinafter referred to as "solid preparation" as appropriate), which contains selected from the group consisting of flupyrazine and its salts represented by the following formula (1) At least one active ingredient, solid carrier, surfactant, and binding agent,

For coated granules or extruded granules.

According to one aspect of the solid preparation of the present invention, there is provided a solid preparation (hereinafter referred to as "coated granules" as appropriate), which is a coated granule, and the solid carrier includes a core particle and an extender. In addition, according to another aspect of the solid preparation of the present invention, there is provided a solid preparation (hereinafter referred to as "extruded granules" as appropriate), which is an extruded granule, and the solid carrier contains an extender. Surfactants include granulation modifiers and collapse and dispersants.

Furthermore, in the present invention, in the "solid formulation for controlling rice pests", in addition to the agent for killing or debilitating the following rice pests, it also includes an agent for excluding rice pests from the following rice, and for controlling A parasitic agent of rice pests on rice, and an agent used to protect rice from rice pests.

(Floperidine) The fluoropyridine, which is the active ingredient of the present invention, is the compound represented by the above formula (1), that is, N-[1-((6-chloropyridin-3-yl)methyl)pyridine-2(1H) -Subunit]-2,2,2-trifluoroacetamide. Flupyrazine can be synthesized in accordance with the production method described in International Publication No. 2012/029672 (Patent Document 1), for example.

In addition, the salt of flupyrazine as the active ingredient of the present invention is preferably an acid addition salt, and the acid addition salt of flupyrazine is more preferably an acid addition salt that is acceptable for agricultural chemicals. Examples of the acid addition salt include hydrochloride, nitrate, sulfate, phosphate, acetate, and the like.

As the active ingredient related to the present invention, it may be one of flupirazine and the aforementioned salt of flupirazine alone, or a combination of two or more kinds.

(Rice pests) The so-called rice pests for which the solid preparation of the present invention exhibits control activity refers to pests that can eat leaves, stems, roots, and ears of rice; pests that can suck juice from leaves, stems, and ears of rice. Such rice pests are not particularly limited, but for example, pests in agriculture and horticulture include lepidopteran (Pteromorpha) pests (Mythimna Separata, S. chinensis, Cnaphalocrocis patnalis (Mythimna Separata), Cnaphalocrocis patnalis ( Marasmia patnalis, Naranga aenescens, Parnara guttata, Plusia festucae, Mythimna loreyi, Protodeltote distinguenda, Spodoptera litura ( Spodoptera depravata), Pelopidas mathias, etc.; Chilo suppressalis (Chilo suppressalis, Chilo suppressalis), Chilo suppressalis (Scirpophaga incertulas), Sesamia inferens, Scirphophaga Innotata, Chilo polychrysus, Chilo auricilius, etc.), Hemiptera (Hemiptera) pests (rice wheat aphid, wheat aphid, rice phylloxera, phylloxera vulgaris, etc.; black tail Leafhoppers, electro-optical leafhoppers, etc.; planthoppers such as Laodelphax striatellus, brown planthopper, white-backed planthopper, etc.; red-striped blind stink bug, rice black stink bug, Chinese rice edge stink bug, white star stink bug, long shoulder spine stink bug , White star stink bug, rice green stink bug, rice leaf stink bug, etc.), coleopteran pests (rice water weevil, rice weevil, bean coriander, rice sludge, rice iron beetle (Dicladispa armigera), etc. ), Acarina (Steneotarsonemus spinki, etc.), Hymenoptera pests, Orthoptera pests (Small winged rice locust, Black-necked frontal chicks, mole crickets, etc.), Diptera pests (rice leaf miners, rice stalks) Liriomyza, Orseolia oryzae, etc.), Thysanoptera pests (rice thrips, rice tube thrips, etc.), plant parasitic nematodes (bessi, Meloidogynae graminicola, etc.) Etc., one of these may be singly, or a combination of two or more. Among them, preferable examples include Pteromorpha pests, Hemiptera pests, Thysanoptera pests, Diptera pests, and Coleoptera Pests, more preferably planthoppers, Chilo suppressalis and leafhoppers, more preferably include Chilo suppressalis, Chilo suppressalis, Laodelphax striatellus, brown planthopper, white-backed planthopper, black-tailed leafhopper, electric leafhopper, More preferably, the planthoppers and Chilo suppressalis among these can be cited.

In addition, as the aforementioned rice pests, there may be drugs that act on nicotine acetylcholine receptors such as Imidacloprid; compounds that act on GABA receptors such as Fipronil and Isp; and Kambo, etc. Existing agents such as diamide compounds, reduce the susceptibility of agents to resist pests.

(Other pest control agents) As the solid preparation of the present invention, since the active ingredient of flupirazine and its salts are those that show excellent control activity against the above-mentioned rice pests by themselves, it is sufficient if they contain the flupirazine and/or its salt. By mixing with other pest control agents, it can also show more excellent control activity against more pests, so it can further contain other pest control agents. Examples of other pest control agents that may be contained include insecticides (including acaricides and nematicides), fungicides, herbicides, and plant growth regulators. Examples of specific agents include pesticide manuals (The Pesticide Manual, 17th edition issued by The British Crop Protection Council) and (SHIBUYA INDEX, 2014, issued by SHIBUYA INDEX RESEARCH GROUP). Among these, insecticides and fungicides are preferable as the aforementioned other pest control agents.

As preferred examples of the aforementioned other pest control agents, for example, organophosphate compounds, phenyl carbamate compounds, worm toxin derivatives, organochlorine compounds, pyrethroid compounds, benzene Formaldehyde compounds, juvenile hormone-like compounds, ecdysone-like compounds, nicotine-like compounds, neuronal sodium channel blockers, insecticidal macrocyclic lactones, γ-aminobutyric acid (GABA) antagonists Agents, Ryanodine receptor (Ryanodine receptor) action compounds, insecticidal ureas, BT agents, insect pathogenic virus agents, polyether antibiotics, thiamine antagonists, and sulfa (Sulfa) agents and folic acid antagonists Drug admixtures, etc.

More specifically, as insecticides, for example, acephate, dichlorvos, EPN, fenitrothion, fenamifos, prothiofos, cloth Organophosphate series of profenofos, pyraclofos, chlorpyrifos-methyl, diazinon, fosthiazate, imicyafos, phorate Compounds; such as methomyl, thiodicarb, aldicarb, oxamyl, propoxur, carbaryl, fenobucarb ), ethiofencarb, fenothiocarb, pirimicarb, carbofuran, carbosulfan, benfuracarb phenylamine Carboxylic acid ester compounds; such as cartap and thiocyclam's oxworm toxin derivatives; such as dicofol and tetradifon's organochlorine compounds; such as Permethrin, tefluthrin, cypermethrin, deltamethrin, cyhalothrin, fenvalerate, fluvalinate ), ethofenprox, silafluofen, cyhalothrin, pyrethroid compounds; such as diflubenzuron, teflubenzuron, flufenoxuron ), chlorfluazuron (chlorfluazuron) benzylurea compounds; such as methoprene juvenile hormone-like compounds; such as Chromafenozide (Chromafenozide) ecdysone-like compounds; such as imidacloprid (imidacloprid) , Clothianidin, thiamethoxam, acetamiprid, nitenpyram, thiacloprid, dinotefuran, sulfoxaflor , Fluopyridone (f Lupyradifurone, dicloromezotiaz, triflumezopyrim nicotine acetylcholine receptor acting drugs; such as flubendiamide, chlorantraniliprole, cyantraniliprole ), cyclaniliprole (cyclaniliprole), tetraniliprole (tetraniliprole) two amide compounds; such as Ethiprole (ethiprole), Fipronil (fipronil), pyrafluprole (pyrafluprole), Pyridoxa GABA receptor-acting compounds of pyriprole, broflanilide, and fluxametamide; such as pyridaben, fenpyroxymate, pyrimidifen, pyrimidifen Tebufenpyrad (tebufenpyrad), tolfenpyrad (tolfenpyrad) respiratory chain electron transport system complex I inhibitory compound; such as cyflumetofen (cyflumetofen), cyenopyrafen (cyenopyrafen), flutamide (pyflbumide) respiratory chain Electron transport complex II inhibitory compounds; such as fluacrypyrim, acequinocyl, flometoquin, respiratory chain electron transport complex III inhibitors; such as spirodiclofen, ACCase inhibitory compounds of spiromesifen and spirotetramat; such as spinosad, avermectin, milbemycin, spinetoram 1. Macrolide compounds of lepimectin and emamectin benzoate.

Furthermore, as other compounds, buprofezin (buprofezin), hexythiazox, amitraz, chlordimeform, ethoxazole, pymetrozine, combined Bifenazate, flonicamid, chlorfenapyr, pyriproxyfen, indoxacarb, pyridalyl, pyrifluquinazon ), metaflumizone, hydramethylnon, triazamate, afidopyropen, renofluthrin, chloroprallethrin, chlorofluoro Cyhalodiamide, fluazaindolizine, epsilon-metofluthrin, epsilon-momfluorothrin, kappa-bifenthrin , Kappa-tefluthrin (kappa-tefluthrin), fluhexafon (fluhexafon), tioxazafen (tioxazafen), momfluorothrin (momfluorothrin), dextefluthrin (heptafluthrin), pyrimate Pyriminostrobin, cycloxaprid, isocycloseram, oxazosulfyl, tyclopyrazoflor, spiropidion, acynonapyr ), dimpropyridaz, organometallic compounds, dinitro compounds, organic sulfur compounds, urea compounds, triazine compounds, hydrazine compounds, such as BT agents, insect pathogenic virus agents, etc. Of microbial pesticides. In addition, as the aforementioned pesticides, acid addition salts that are acceptable on these pesticides can also be cited.

As the aforementioned insecticide, although one of the above-mentioned insecticides may be used alone or in combination of two or more types, among them, preferred insecticides include cartap, thiocyclam, and thiocyclam. Phorate, flubendiamide, chlorantraniliprole, cyantraniliprole, carbofuran, fipronil.

Also, more specifically, as the fungicide, for example, azoxystrobin (azoxystrobin), kresoxym-methyl, trifloxystrobin, metominostrobin, orysastrobin can be cited. (orysastrobin) and other strobilurin compounds; mepanipyrim, pyrimethanil, cyprodinil, anilinopyrimidine (anilinopyrimidine) compounds; such as strobilurin triadimefon, bitertanol, triflumizole, metoconazole, propiconazole, penconazole, flusilazole, myclobutanil , Cyproconazole, tebuconazole, hexaconazole, prochloraz, simeconazole azole compounds; such as quinomethionate (quinomethionate) Phrinoid compounds; such as maneb, zineb, mancozeb, polycarbamate, propineb dithiobenzene Carbamate series compounds; such as diethofencarb's phenyl phenyl carbamate series compounds; such as chlorothalonil (chlorothalonil), pentachloronitrobenzene (quintozene) organochlorine series Compounds; such as benomyl, thiophanate-methyl, and carbendazole benzimidazole compounds; such as metalaxyl, oxadixyl, Phenylamide compounds of ofurase, benalaxyl, furalaxyl, cyprofuram; such as dichlofluanid sulfonic acid compounds ; Such as copper hydroxide (copper hydroxide), oxine-copper (oxine-copper) copper compounds; such as hydroxyisoxazole (hydroxyisoxazole) isoxazole compounds; such as fosetyl-aluminium (fosetyl-aluminium), dec Pine (tolclofos-methyl) organophosphorus compounds; such as captan (captan), captafol, folpet N-halogen thioalkyl compounds; such as procymidone, iprodione, vinchlozolin ) Of two carbodiimide (Dicarboximide) compounds; such as flutolanil, mepronil, furametpyr, thifluzamide, boscalid, flat Carboxyaniline compounds of penthiopyrad; morpholine compounds such as fenpropimorph and dimethomorph; such as fenthin hydroxide and triphenyltin acetate (fenthin acetate) organotin compounds; such as fludioxonil (fludioxonil), fenpiclonil (fenpiclonil) cyanopyrrole compounds.

Furthermore, as other compounds, tricyclazole, pyroquilon, carpropamid, diclocymet, fenoxanil, and tetrachlorobenzene can be cited. Phthalide, fluazinam, cymoxanil, triforine, pyrifenox, fenarimol, fenpropidin, pentobacter Pencycuron, ferimzone, cyazofamid, iprovalicarb, benthiavalicarb-isopropyl, iminoctadin-albesilate, cyazofamid (cyflufenamid), kasugamycin, validamycin, streptomycin, oxolinic-acid, tebufloquin, probenazole , Tiadinil, isotianil, isoprothiolane, tolprocarb, pydiflumetofen, picarbutrazox, amygdalin (mandestrobin), dipymetitrone, pyraziflumid, oxathiapiprolin, penflufen, fluoxapiprolin, florylpicoxamid, flufenoxamid (fluopimomide), ipfenoquin, fluindapyr, isoflucypram, quinofumelin, methyltetraprole, pyridachlometyl, pyrapropoyne, Aminopyrifen, inpyrifluxam, dichlobentiazox, etc. Moreover, as the above-mentioned bactericide, the acid addition salt which is acceptable on these agricultural chemicals can also be mentioned.

As the aforementioned bactericide, although one of the above-mentioned bactericides may be used alone or in combination of two or more types, among them, azoxystrobin (azoxystrobin), orysastrobin (orysastrobin), orysastrobin (orysastrobin) may be cited as preferred bactericides. Thifluzamide, furametpyr, fthalide, probenazole, acibenzolar-S-methyl, thifluzamide Tiadinil, isotianil, isoprothiolane, tolprocarb, carpropamid, diclocymet, fenoxanil ( fenoxanil, tricyclazole, pyroquilon, ferimzone, tebufloquin, simeconazole, validamycin, Jiacizhengsu (Kasugamycin), pencycuron, penflufen, dichlobentiazox.

(additive) The solid preparation of the present invention can be manufactured by using an additive (preferably an additive that is acceptable for pesticides) due to the active ingredient of flupirazine. Examples of the form include granules, and more specifically, coated granules or extruded granules containing a solid carrier, a surfactant, and a binding agent.

[Solid Carrier] Examples of the aforementioned solid carrier include talc, bentonite, clay, kaolin, diatomaceous earth, vermiculite, zeolite, silica, calcium carbonate, ammonium sulfate, silica sand, silica, pumice, and the like.

The coated granule of the present invention is the aforementioned solid carrier and contains core particles and an extender. In addition, the extruded granule of the present invention contains an extender in the solid carrier, and preferably does not contain the core particles, that is, the solid carrier only contains the extender.

In the present invention, the so-called "core particle" refers to a solid carrier with a particle size of 63μm or more. As the aforementioned particle size, it is preferably in the range of 63μm to 6mm, more preferably in the range of 75μm to 2mm, and still more preferably Within the range of 106μm~2mm. The "particle size" of the core particle or solid carrier of the present invention refers to the diameter of the circle when the particle is projected onto the plane. The projection surface is not circular (the particle is flat, plate, etc., rod-shaped, polygonal, etc.). When the shape is equal to), it refers to the diameter of its circumscribed circle. As such core particles, there are no particular restrictions if they meet the aforementioned particle size, but granular silica sand, diatomaceous earth, pumice, clay, calcium carbonate, etc. can be cited. One of these particles can be used alone. It can also be a combination of two or more types. In addition, in the present invention, in the granular calcium carbonate (granular calcium carbonate) and granular clay (granular clay), in addition to the particles of the pulverized product of each mineral, it also includes mineral fine powders with small particle diameters. It is mixed with bentonite or the following binders, kneaded, and granulated by extrusion or crushing to form granular granules.

In the present invention, the so-called "extender" refers to a user whose purpose is to dilute the active ingredient. Specifically, it refers to a solid carrier with a particle size of less than 63 μm. As such an extender, if it satisfies the aforementioned particle size, it is not particularly limited, but it is preferable for the aforementioned coated granules. From the viewpoint of ease of the pulverization step in the manufacturing method of the following coated granules In view, it is at least one selected from the group consisting of clay, calcium carbonate, kaolin and silica. In addition, the aforementioned extruded granules are preferable. From the same viewpoint, they are at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silica, and bentonite.

[Surfactant] Examples of the aforementioned surfactant include anionic surfactants, cationic surfactants, and nonionic surfactants.

As the surfactant contained in the coated granules of the present invention, among the above, those having the wetting effect of the aforementioned core particles are preferred. Specifically, for example, sodium lignosulfonate, sodium lauryl sulfate, and naphthalene can be mentioned. Sodium sulfonate formalin condensate, polyoxyalkylene alkyl ether sodium sulfate, sodium alkylbenzene sulfonate, sodium dialkylsulfosuccinate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene benzene Anionic surfactants such as sodium vinyl phenyl ether phosphate; polyoxyalkylene sorbitol fatty acid esters (polyoxyalkylene sorbitol monolaurate, etc.), sorbitol fatty acid esters, sucrose fatty acid esters, polyoxyalkylene sorbitol fatty acid esters, etc. Oxyalkylene castor oil, polyoxyalkylene hardened castor oil, polyoxyalkylene alkyl ether, polyoxyalkylene alkyl phenyl ether, polyoxyalkylene styryl phenyl ether, polyoxyethylene and polyoxypropylene block polymer, Nonionic surfactants such as polyoxyalkylene alkyl amines may be one of them alone or a combination of two or more. Among the aforementioned surfactants, the aforementioned nonionic surfactants or combinations thereof can be used for the same purpose as the following binders in the coated granules of the present invention.

In addition, in this specification, "polyoxyalkylene" means one or a mixture of polyoxyethylene and polyoxypropylene.

The extruded granules of the present invention are the aforementioned surfactants, and contain a granulation improving agent and a collapse and dispersing agent.

In the present invention, the so-called "granulation modifier" means that among the surfactants mentioned above, in the kneading step of the following manufacturing method, it has the effect of enhancing the compatibility of water with other ingredients. Specifically, it means that it is defined as In the case of 0.1% aqueous solution, it is a surfactant with a surface tension value of 10~35mN/m at 25°C. As such a granulation improver, if it satisfies the above-mentioned surface tension, it is not particularly limited, but in the aforementioned extruded granules, it is preferably selected from sodium lauryl sulfate and dialkyl sulfosuccinic acid. At least one of the group consisting of sodium and sodium alkylbenzene sulfonate.

In the present invention, the so-called "collapsing and dispersing agent" means that among the above-mentioned surfactants, in addition to the above-mentioned granulation modifier, it has the ability to improve the dispersibility and disintegration of the other ingredients of the above-mentioned active ingredient. The role of at least one of them. As such a collapse and dispersant, anionic surfactants are preferred, and sodium lignosulfonate, calcium lignosulfonate, sodium naphthalenesulfonate formalin condensate, sodium polyacrylate are more preferred. , Polyoxyethylene alkyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether phosphate sodium, polyoxyethylene･polyoxypropylene polymer sodium sulfate, can be among these One type alone may also be a combination of two or more types.

[Binding agent] In the present invention, the "binding agent" is mainly used for the purpose of increasing the strength of the solid preparation and/or enhancing the connection between the solid raw materials. Examples of such binding agents include cellulose derivatives such as sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, or methyl cellulose; polyacrylates such as sodium polyacrylate; polymethyl methacrylate Polymethacrylates such as esters; polyethylene derivatives such as polyvinyl alcohol or polyvinylpyrrolidone; rubbers (vegetable rubbers, etc.) such as xanthan gum, guar gum, and gum arabic; starch; dextrin; Sugars such as monosaccharides (fructose, glucose, galactose, etc.) or disaccharides (sucrose, maltose, lactose, etc.); gums; casein; gelatin; fluid paraffin; vegetable oils such as soybean oil or rapeseed oil; polyethylene glycol Glycols such as alcohol or polypropylene glycol may be one of these alone or a combination of two or more.

As the binder contained in the coated granule of the present invention, among the above, at least one selected from the group consisting of fluid paraffin, vegetable oil, polyethylene glycol, and polypropylene glycol is preferred. Furthermore, as the binder contained in the extruded granules of the present invention, among the above, it is preferable to be selected from the group consisting of polyvinyl alcohol, dextrin, sugars, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and methyl cellulose. At least one of the group of base cellulose.

[other] Furthermore, as the solid preparation of the present invention (preferably coated granules), it may further contain a coloring agent such as a red pigment or a blue pigment.

In addition, the solid preparation of the present invention may further contain surfactants, emulsifiers, dispersants, disintegrants, wetting agents, spreading agents, etc. other than the above, if necessary, within a range that does not hinder the effects of the present invention. At least one of other additives such as tackifier, bonding agent, anti-freezing agent, defoamer, coloring agent, and anti-mold agent.

[composition] As the amount of active ingredients contained in the solid preparation of the present invention (if flupyrazine or its salt contains two or more, the total amount is the same, the same applies below), because it also depends on the purpose of use or processing method Although it is not particularly limited, it is usually 0.1 to 80% by weight, preferably 0.1 to 10% by weight, in terms of free body of fluorpyrazine.

As a preferable aspect of the solid preparation of the present invention, the following can be cited. (1) Containing 0.1-10% by weight of flupyrazine, 20-98% by weight of nuclear particles (granular solid carrier such as silica sand), and 0.2-30% by weight of extenders, surfactants and binding agents, respectively (more Preferably 0.5~30% by weight), the total becomes 100% by weight of coated granule, (2) Extrusion pellets containing 0.1-10% by weight of flupyrazine, 0.5-30% by weight of surfactant and binding agent, 20-98% by weight of extender (solid carrier), and a total of 100% by weight Extruded granule, (3) Contains 0.1 to 10% by weight of flupiramide, 20 to 98% by weight of extender (solid carrier), 0.1 to 2.0% by weight of granulation improver, 0.5 to 5.0% by weight of collapsing and dispersing agent, and binding agent 0.5-30% by weight, totaling 100% by weight extruded granules.

＜Method of manufacturing solid preparation＞ The present invention, as an aspect of the manufacturing method of the solid preparation of the present invention, provides a manufacturing method (hereinafter, as the case may be referred to as "the manufacturing method of coated granules"), which includes: Adding the aforementioned binding agent or the aforementioned binding agent and the aforementioned surfactant to the aforementioned core particles to make them wet to obtain the wetting step of the wet core particles, and Mixing the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender, or the aforementioned active ingredient and the aforementioned extender and pulverizing to obtain the first mixing and pulverizing step of mixing and pulverizing, and The step of mixing the wet core particles with the first mixed and pulverized product to obtain coated granules whose surface is covered with the first mixed and pulverized product, and a manufacturing method (hereinafter, as the case may be referred to as "extrusion type") The manufacturing method of granules"), which includes: Mix the aforementioned active ingredient, the aforementioned extender, and the aforementioned binder and pulverize, or mix the aforementioned active ingredient, the aforementioned extender, and the aforementioned binder with the aforementioned granulation modifier and/or the aforementioned collapse/dispersant and pulverize, and The mixing and pulverizing step of obtaining the second mixed and pulverized product, and Kneading the second mixed and pulverized product and water, or kneading the second mixed and pulverized product and water with the aforementioned granulation modifier and/or the aforementioned collapse and dispersant to obtain a kneaded product, and The step of forming the aforementioned kneaded mixture with an extrusion granulator to obtain extruded granules.

[Manufacturing method of coated granules] The coated granule of the present invention is a granule formed by coating the active ingredient and the extender with a binder on the surface of the core particle. The core particles are wetted with the binder in advance (wetting step) in a way that they can be easily coated. In this wetting step, the aforementioned surfactant (preferably a nonionic surfactant) can be further added. The wetting step is not particularly limited. Although a conventionally known method or a method according to it can be suitably used, for example, the core particles may be sprayed with the binder and, if necessary, the surfactant. Method of mixing. As the binding agent in this case, it can be used after being diluted with a solvent such as water or ethanol.

In addition, the coated ingredients are added with extenders beforehand, uniformly mixed and crushed. That is, the active ingredient, the surfactant, and the extender are mixed, and pulverized (at least the active ingredient and the extender are pulverized) to obtain a first mixed and pulverized product (mixing and pulverizing step). At this time, when the surfactant is added in the wetting step, the active ingredient and the extender are mixed and pulverized to obtain a first mixed and pulverized product. As the aforementioned surfactant, it can be used in two steps, a wetting step and a mixing and pulverizing step. There are no particular restrictions on such a pulverization method. A conventionally known method or a method according to it can be suitably used. For example, a jet mill using a pin mill, a hammer mill, etc., or a jet mill, etc. The method of the shredder.

The aforementioned wetting step and the mixing and pulverizing step can be performed either first, or at the same time. Next, the wet core particles and the first mixed and pulverized product are mixed to obtain a coated granule in which the surface of the wet core particles is covered with the first mixed and pulverized product. Such a mixing method is not particularly limited, and a conventionally known method or a method according to it can be appropriately used. For example, a container rotary mixer using a concrete mixer, etc.; a belt mixer or a conical screw mixer can be mentioned. The method of the container fixed type mixer.

As a manufacturing method of the coated granules, if necessary, a drying step of drying the aforementioned coated granules may be further included. There are no particular restrictions on such a drying method, and a conventionally known method or a method according to it can be suitably used.

[Method of manufacturing extruded granules] The extruded granules of the present invention are those obtained by uniformly mixing the aforementioned active ingredient and the aforementioned extender, etc., and pulverizing them, adding water and kneading them to shape them into granules. That is, first, the active ingredient, the extender, the granulation improver, the collapse/dispersant, and the binder are mixed and pulverized (at least the active ingredient and the extender are pulverized) to obtain the first 2 Mix and pulverize (mixing and pulverizing step). In this mixing and pulverizing step, the granulation improving agent and/or the collapsing and dispersing agent are not added, and can be added in the next kneading step. As such a pulverization method, the same method as the pulverization method exemplified in the manufacturing method of coated granules can be suitably adopted. In addition, as the binding agent in this case, it can be used in the form of a solution by dissolving it in a solvent such as water or ethanol.

Next, kneading (kneading) the second mixed and pulverized product and water without adding the second mixed and pulverized product and water, or without adding the granulation modifier and/or the aforementioned collapse and dispersing agent in the aforementioned pulverization step With the aforementioned granulation improving agent and/or the aforementioned collapsing and dispersing agent, a kneaded compound is obtained. In addition, as the granulation improving agent and the collapsing/dispersing agent, they can be used separately in two steps, a mixing and pulverizing step and a kneading step. The kneading method is not particularly limited, and a conventionally known method or a method according to it can be suitably used. Examples include the use of a belt mixer, a conical screw mixer, a Henschel mixer, and a double-wrist type kneading machine. The method of mixing and kneading machine, etc.

Next, the aforementioned kneaded product is molded with an extrusion-type pelletizer to obtain extruded pellets. As such a molding method, there is no particular limitation, and a conventionally known method or a method according to it can be suitably used. For example, as the aforementioned extrusion type granulator, a structure by extrusion can be mentioned. For horizontal extrusion type, front extrusion type, hard type, roller extrusion type, the aforementioned kneaded material can be applied with screws or rollers. Pressure, a method of extruding from a screen or die (Die).

After the molding of the aforementioned extruded granules, if necessary, a drying step of drying the granules may be further included. There are no particular restrictions on such a drying method, and a conventionally known method or a method according to it can be suitably used.

According to another preferred aspect of the present invention, as a composition, there is provided the solid preparation of the present invention, namely the first composition, and the composition containing other pest control agents as effective ingredients, namely the second composition The combination of things. In this case, the second composition can be made into any dosage form by adding appropriate additives. The composition can be provided in the form of a pharmaceutical kit or the like.

According to yet another aspect of the present invention, which is a method for protecting rice from rice pests, it provides a method comprising combining the solid preparation of the present invention and at least one of other pest control agents, simultaneously or separately (preferably In order to apply each component at the same time), the method is applied to the applicable object (the area to be treated). In this method, "simultaneous" application also includes mixing the solid formulation of the present invention and at least one of other pest control agents before applying to the subject, and applying the mixture thereof. The "respectively" application includes not mixing these in advance, applying the solid preparation of the present invention prior to other ingredients, and applying the solid preparation of the present invention more later than other ingredients.

＜Methods of controlling rice pests＞ The present invention provides a method for controlling rice pests (hereinafter, referred to as "controlling method" as appropriate), which comprises applying the above-mentioned solid formulation of the present invention to the rice pests, rice, soil, and field surface. At least one step in the group.

Still, in the present invention, the "method for controlling rice pests", in addition to the method of killing or debilitating the aforementioned rice pests, includes the method of eliminating rice pests from the following rice, the method of preventing the parasitic of rice pests on rice, and the protection Methods of protecting rice from pests of rice.

[Rice] Although the plant to which the solid preparation of the present invention can be applied is not particularly limited, rice (Oryza sativa, Oryzaglaberrima) is preferred. Rice is a plant belonging to the genus Oryza in the Gramineae family. Specifically, it is divided into two ecotypes of japonica species (O.sativa subsp.japonica) and indica species (O.sativa subsp.indica), and the intermediate Sexual variety. Java rice is included in the japonica rice species.

The rice line is cultivated in a very wide range of areas centered on the Asian monsoon zone and is cultivated under various climatic conditions. It is cultivated on the Heilongjiang River on the border between Russia and China in the north, and crosses Argentina in the south. In the mountainous areas of Nepal and India; the sandy desert areas of Pakistan, Iran, and Egypt have been cultivated by irrigation, while in parts of Asia, Africa and Latin America, they have not been cultivated. In addition, it is cultivated as floating rice in the deltas of Asia.

By the cultivation method, rice is divided into upland rice and rice. Upland rice is sown directly in the field and cultivated in the field. Although there is also direct seeding cultivation of rice directly sown in the paddy field, in Japan, the cultivation method is generally to transplant the seedlings to the paddy field (field planting).

The temperature that can be cultivated is usually above 20°C, and rice is cultivated under Zhanshui conditions (paddy fields). The minimum temperature for growth is 10~12℃, and it must be 23℃ for flowering and fruiting. Conversely, when the temperature is increased to 35°C or higher, a high temperature barrier occurs.

Originally aquatic plants, rice plants are one of the crops that require a large amount of water. Without irrigation, the soil moisture at the surface layer is below 10%, and when the underlying soil is below 12%, drought damage will occur. However, it can also be cultivated in salt accumulation soil, alkali or acid soil.

The solid preparation of the present invention is cultivated in rice, particularly preferably in rice cultivation, and can be applied in any period from sowing (preferably after transplantation) to harvest. For example, 2 to 5 weeks after transplanting seedlings, by applying the solid preparation of the present invention to the water surface (field water surface) of the transplanted rice field (rice paddy field), the aforementioned rice pests that occur in different periods can be controlled at one time. Furthermore, the aforementioned field water surface also includes the water surface of hydroponic cultivation equipment such as the Wasabi basin. The solid preparation of the present invention can be applied to the soil containing the cultivation carrier before transplantation, or the soil for cultivating the aforementioned upland rice, etc., in addition to the aforementioned field water surface. It can also be directly applied to the aforementioned rice pests or rice (preferably stems and leaves). unit). Among these, as the object to which the solid preparation of the present invention is applied, at least one of the aforementioned soil (cultivation soil and cultivation carrier before transplantation, soil for cultivating upland rice, etc.) and the aforementioned field water surface is preferred.

Furthermore, in the control method of the present invention, the solid preparation of the present invention can be applied as it is or diluted in such a way that the solid preparation of the present invention becomes an effective amount.

According to another aspect of the present invention, there is provided a method for protecting rice from rice pests, which comprises applying an effective amount of the solid preparation of the present invention to the rice pests and the rice (preferably stems and leaves). ), a step of at least one of the groups formed by the aforementioned soil and the aforementioned field water surface.

Furthermore, according to another aspect of the present invention, there is provided a use of the solid preparation of the present invention for protecting rice from rice pests.

The method of applying the solid preparation of the present invention to an object includes spray treatment, field water treatment, soil treatment (spreading, mixing, pouring, etc.), and preferably field water treatment and soil treatment.

As a method of using the solid preparation of the present invention in field water treatment and soil treatment, although the solid preparation can be directly spread on the field water or soil surface, after mixing with fertilizer or sand, any amount can be spread on the cultivated land ( paddy). As the treatment amount (that is, the effective amount) when applied by field water treatment and soil treatment, it is desirable to use the amount of the active ingredient in the solid preparation of the present invention (the amount converted to the free body of flupyrazine or its salt, containing this In the case of two or more types, the total amount is the same, and the following is the same.) The cultivated land is 0.1 g to 10 kg per 10 ares, preferably 1 g to 1 kg.

In addition, as a soil treatment method by the solid preparation of the present invention, although not particularly limited, a method of directly applying the solid preparation of the present invention to the soil or on the surface of the soil is preferably mentioned. The better soil treatment method is the application method of spreading, belt, furrow and planting hole.

As other application methods, the present invention can be used for the nutrient solution of the hydroponic cultivation system such as thin film hydroponics (NFT) or infusion hydroponics (DFT), solid medium cultivation such as rock wool cultivation. The application of the solid preparation, or the direct application to the artificial soil containing vermiculite and the solid medium containing artificial pad for raising seedlings. In addition, although it is not good from the viewpoint of continuous control activity over a long period of time, the solid preparation of the present invention can be applied by dispersing in water or pouring an emulsified or dissolved solution into soil. [Example]

Hereinafter, although the present invention will be specifically described with examples, the present invention is not limited to these examples. However, the raw materials of each preparation example are all commercially available products. In addition, in each preparation example, only solid carriers (core particles) having a particle size of 63 μm or more are referred to as particle size.

(Preparation example) Formulation example 1 [Extrudable granules] Flupyrazine 2% by weight Sodium lignosulfonate 3% by weight Sodium lauryl sulfate 0.5% by weight Silicon dioxide 2% by weight Polyvinyl alcohol 1.5% by weight Clay 91% by weight The above components are uniformly mixed and pulverized, and water is added to fully knead, and the kneaded product is passed through an extrusion-type granulator for granulation and drying to obtain granules.

Formulation example 2 [Extrudable granules] Flupyrazine 2% by weight Calcium lignosulfonate 3% by weight Sodium alkylbenzene sulfonate 0.5% by weight Silicon dioxide 2% by weight Polyvinyl alcohol 1% by weight Clay 91.5% by weight The above components are uniformly mixed and pulverized, and water is added to fully knead, and the kneaded product is passed through an extrusion-type granulator for granulation and drying to obtain granules.

Formulation example 3 [Extrudable granules] Flupyrazine 2% by weight Sodium polyacrylate 2% by weight Sodium dialkylsulfosuccinate 0.3% by weight Sodium carboxymethylcellulose 1.5% by weight Calcium carbonate 94.2% by weight The sodium polyacrylate is removed, the above-mentioned ingredients are uniformly mixed and crushed, the sodium polyacrylate and water are added to the sodium polyacrylate and water and fully kneaded, the kneaded product is passed through an extrusion granulator to granulate and dry to obtain granules.

Formulation example 4 [Extruded granules] Flupyrazine 2% by weight Sodium lignosulfonate 3% by weight Sodium alkylbenzene sulfonate 0.3% by weight Dextrin 5 wt% Kaolin 10% by weight Clay 79.7 wt% The above components are uniformly mixed and pulverized, and water is added to fully knead, and the kneaded product is passed through an extrusion-type granulator for granulation and drying to obtain granules.

Formulation Example 5 [Extruded granules] Flupyrazine 2% by weight Sodium naphthalenesulfonate formalin condensate 3% by weight Sodium lauryl sulfate 0.3% by weight Sodium carboxymethylcellulose 1.5% by weight Talc 30% by weight Calcium carbonate 63.2% by weight The above components are uniformly mixed and pulverized, and water is added to fully knead, and the kneaded product is passed through an extrusion-type granulator for granulation and drying to obtain granules.

Formulation example 6 [Coated granules] Flupyrazine 2% by weight Silica sand (granular: particle size 0.3~1.4mm) 95.55 wt% Sodium lauryl sulfate 0.1% by weight Silicon dioxide 0.5% by weight Flowing paraffin wax 1.15 wt% Red pigment 0.2% by weight Kaolin 0.5% by weight The components other than the above-mentioned silica sand and fluid paraffin are uniformly mixed and pulverized to obtain a pulverized product. After adding fluidized paraffin to the silica sand and making it uniformly wet, the aforementioned pulverized product is added and uniformly mixed, and the aforementioned core particles are coated with the aforementioned pulverized product to obtain granules.

Formulation example 7 [Coated granules] Flupyrazine 2% by weight Silica sand (granular: particle size 0.3~1.4mm) 95.85 wt% Sodium lauryl sulfate 0.1% by weight Silicon dioxide 0.75% by weight Polypropylene glycol 1.1% by weight Red pigment 0.2% by weight The components other than the aforementioned silica sand and polypropylene glycol are uniformly mixed and pulverized to obtain a pulverized product. After adding polypropylene glycol to the silica sand and making it uniformly wet, the pulverized product is added and uniformly mixed, and the core particles are coated with the pulverized product to obtain granules.

Formulation example 8 [Coated granules] Flupyrazine 2% by weight Sodium alkylbenzene sulfonate 0.1% by weight Kaolin 1% by weight Red pigment 0.2% by weight Polyethylene glycol 1.15 wt% Granular calcium carbonate (Particle size 0.42~0.85mm) 95.55 wt% The above-mentioned granular calcium carbonate and components other than polyethylene glycol are uniformly mixed and pulverized to obtain a pulverized product. After adding polyethylene glycol to the granular calcium carbonate and making it uniformly wet, the pulverized product is added and uniformly mixed, and the core particle is coated with the pulverized product to obtain a granule.

Formulation example 9 [Coated granules] Flupyrazine 2% by weight Sodium alkylbenzene sulfonate 0.1% by weight Silicon dioxide 0.5% by weight Kaolin 0.5% by weight Blue pigment 0.2% by weight Polypropylene glycol 1.15 wt% Silica sand (granular: particle size 0.25~1.0mm) 95.55 wt% The components other than the aforementioned silica sand and polypropylene glycol are uniformly mixed and pulverized to obtain a pulverized product. After adding polypropylene glycol to the silica sand and making it uniformly wet, the pulverized product is added and uniformly mixed, and the core particles are coated with the pulverized product to obtain granules.

Formulation example 10 [Coated granules] Flupyrazine 2% by weight Kaolin 1.5% by weight Blue pigment 0.2% by weight Sodium dialkylsulfosuccinate 0.1% by weight Polyoxyalkylene sorbitol fatty acid ester 0.2% by weight Soybean oil 1% by weight Silica sand (granular: particle size 0.25~1.0mm) 95% by weight Flupyrazine, kaolin, and blue pigment are uniformly mixed and pulverized to obtain a pulverized product. Add the pre-mixed mixture of sodium dialkyl sulfosuccinate, polyoxyalkylene sorbitol fatty acid ester, and soybean oil to the silica sand and make it uniformly moisturized, then add the pulverized product, mix it uniformly, and add to the aforementioned core particles The pulverized product is covered to obtain granules.

Comparative preparation example 1 [Flowing agent] Flupyrazine 10% by weight Sodium lignosulfonate 2.5% by weight Sodium dialkylsulfosuccinate 0.2% by weight Propylene glycol 10% by weight Xanthan gum 0.3% by weight Polysiloxane-based defoamer 0.5% by weight Antifungal agent (Organic nitrogen-sulfur compound, organic bromine compound) 0.03% by weight Water 76.47% by weight After adding fluperazine, sodium lignosulfonate, sodium dialkyl sulfosuccinate, propylene glycol and polysiloxane defoaming agent to water and mixing, perform wet pulverization by a bead mill to obtain slurry (A liquid). Next, xanthan gum, antifungal agent, and water are mixed and dissolved to obtain an aqueous solution (liquid B). 780 parts by weight of the prepared liquid A and 230 parts by weight of the liquid B were mixed to obtain a fluidizing agent.

Comparative preparation example 2 [granule hydrating agent] Flupyrazine 20% by weight Sodium dialkylsulfosuccinate 1% by weight Sodium lignosulfonate 7 wt% Silicon dioxide 1% by weight Clay 71% by weight The above components are uniformly mixed and pulverized, water is added and kneaded sufficiently, and the kneaded product is passed through an extrusion-type granulator for granulation and drying to obtain a granular hydrating agent.

(Test Example 1 Field test for Chilo suppressalis and planthoppers) For the rice field 25 days after the field planting, the original body amount (the amount of active ingredient, the amount of flupyrazine is the same as the amount of flupyrazine, the same below) becomes the specified amount, and the granules of formulation example 1 (extruded type) Granules) are treated by water surface application (field surface water treatment). For the control formulation, after 25 days of planting in the field, the Pedan 4% granules of Chilo suppressalis control formulations were treated with the original amount (the amount of Pedan) as the specified amount, and then treated by surface application, and then After 3 weeks (21 days) of the treatment, the 25% flow agent of the planthopper control agent was sprayed on the stems and leaves so that the original amount (the net amount of butofol) became the designated amount. For the untreated area, no formulations were applied.

On the 14th, 21st, 28th, and 35th days after the preparation treatment (25 days after planting in the field), the number of tillers of 20 randomly selected plants in each district and the number of tillers caused by Chilo suppressalis (mainly Chilo suppressalis) Number of damaged stems. According to the following formula, calculate the damaged stem rate. Damaged stem rate (%)=(number of damaged stems on each treatment day/total number of tillers of 20 plants)×100 The results are shown in Table 1 below. Also, after 14, 21, 28, 35, and 42 days, the total number of planthoppers (the total number of brown planthoppers and white-backed planthoppers) parasitic in each of 20 randomly selected plants in each district (the number of adults and larvae) The total number of parasites as planthoppers. The results are shown in Table 2 below.

The results of the test, as shown in Tables 1 and 2, in the solid preparation of the present invention, flupirazine granules, at a treatment amount of 100g/ha, it was confirmed that it not only showed higher damage compared to the control preparations of Chilo suppressalis The inhibitory effect also significantly suppresses the number of parasites such as planthoppers. On the other hand, in the treatment area (system control treatment area) of Peidan granules and Bufenjing fluid agent of the control formulation, the rate of damaged stems caused by Chilo suppressalis is lower than that in the untreated area, but it is The reduction rate of the number of parasites of planthoppers is small, and the effect of suppressing density of planthoppers is low. In this way, it is confirmed that the flupirazine granules of the present invention have long-term continuity after only one treatment. Compared with the control formulations of the control formulations of Chilo suppressalis and planthoppers, the system treatment of Chilo suppressalis and planthoppers is more effective Stem borers and planthoppers show higher control activity.

In addition, by comparing the weight of rice harvested from each treatment area, the effect on the yield of rice of each formulation was evaluated. The results are shown in Table 3 below.

As shown in Table 3, in the treatment area of flupirazine granules, it was confirmed that the system control treatment area was higher than that of the control formulation, and the effect of increasing the yield by 12% for the untreated area was confirmed. Based on the above results, according to the solid preparation (extruded granules) of the present invention, it was confirmed that the single treatment not only reduces the labor of rice pest control operations, but also shows a more excellent income-increasing effect than the control preparation. .

(Test Example 2 Indoor test for brown planthopper) Transplant the rice 3 weeks after sowing into a Waschner basin (1/5000a), and 3 days after transplantation, use the granules (extruded granules) of Manufacturing Example 1 or manufacture them in such a way that the amount of the original body becomes the specified amount. The granules of Example 6 (coated granules), or flupyrazine, were treated by surface application (field surface water treatment). For the untreated area, no preparations and medicaments were applied. Feed the second-instar larvae of Nilaparvata lugens on the 3rd, 29th, and 42nd day after the preparation or medicament treatment (3 days after transplantation), and observe the life and death of the larvae after 6 days or 7 days after the feeding, according to the following formula Calculate the modified death rate. Modified rate of dead insects (%)=[{(Number of surviving insects in no-treatment area/Number of feeding insects)-(Number of surviving insects in treatment area/Number of feeding insects)}/(Number of surviving insects in no-treatment area/Release Feeding insects)]×100 The test is carried out in a 2-continuous system. The results are shown in Table 4 below.

The results of the test, as shown in Table 4, in the solid preparations of the present invention, namely the coated granules and extruded granules of flupyrazine, after 29 and 42 days of each treatment, even if the rice pests were fed, they also showed better results. Flurpyrazine has a higher modified mortality rate. Therefore, it is confirmed that by using these granules, the long-term sustainability is better than that of the original body.

(Test Example 3 Field test for Chilo suppressalis) After mixing the granules (extruded granules) of Formulation Example 1 with an appropriate amount of sand, the rice field after transplantation 25 days after transplantation, the original amount becomes the designated amount The way, by uniform water surface application, for treatment (field surface water treatment). Also, on the same day, the fluid agent of Comparative Formulation Example 1 was diluted with water so that the treatment water amount was 40 L/10a, and the stem and leaf parts were sprayed with a sprayer so that the original body amount became a predetermined amount. For the untreated area, no formulations were applied. During the preparation treatment, although no damage to the stems caused by Chilo suppressalis (the dominant species of Chilo suppressalis) was observed, the number of stems and their causes were counted visually after 28 days and 42 days after treatment. The number of core withered stems caused by Chilo suppressalis (the dominant species of Chilo suppressalis). The survey was conducted for every 30 plants in a 25m ² area, and the damaged stem rate was calculated using the following formula. Damaged stem rate (%)={(Number of core dead stems per 30 plants)/(Total number of stems per 30 plants)}×100 The results are shown in Table 5 below.

As shown in Table 5, the extruded granules of the present invention also showed high control activity against Chilo suppressalis (the dominant species of Chilo suppressalis) over a longer period of time than the flow agent.

(Test Example 4 Field test for brown planthopper) After mixing the granules (extruded granules) of Formulation Example 1 with an appropriate amount of sand, the rice field after transplantation 25 days after transplantation, the original amount becomes the specified amount, Treatment (field surface water treatment) is carried out by uniform water surface application. Also, on the same day, the fluid agent of Comparative Formulation Example 1 was diluted with water so that the treated water amount was 40 L/10a, and the stems and leaves were sprayed with a sprayer so that the original amount became a specified amount. For the untreated area, no formulations were applied. During the preparation treatment, although no parasitism of rice planthoppers by planthoppers was observed, the number of adults and larvae of the brown planthopper parasitic on each plant head was counted visually after 31, 49, and 56 days of treatment. The results of the survey per 30 plants in an area of 25 m ^{2 are} shown in Table 6 below in terms of the number of parasites per plant (total of adults and larvae).

As a result of the test, as shown in Table 6, the extruded granules of the present invention also showed high control activity against brown planthoppers over a longer period of time than the flowable agent.

(Reference test example for comparison test of granular hydrating agent and fluidizing agent) The fluidizing agent of Comparative Preparation Example 1 or the granular hydrating agent of Comparative Preparation Example 2 was diluted with water so that the treated water volume was 150L/10a, and the original body When the amount becomes the specified amount, spray the rice stems and leaves 48 days after transplantation with a sprayer. For the untreated area, no formulations were applied. Before each treatment and 4, 7, 19, and 33 days after the treatment, wipe off the planthoppers parasitic on each plant head on the A4 size adhesive board, and count the number of adults and larvae of Laodelphax striatellus by visual observation. The results of the survey per 30 plants in an area of 24 m ^{2 are} shown in Table 7 below in terms of the number of parasites per plant (total of adults and larvae).

The results of the test, as shown in Table 7, showed that the fluidizing agent and the granular hydrating agent showed the same level of control activity against Laodelphax striatellus. Therefore, based on the above results, the extruded granules of the present invention, compared with the granular hydrating agent, can be said to show high control activity over a long period of time. [Industrial availability]

As explained above, according to the present invention, it becomes possible to provide a novel solid preparation for controlling pests, especially rice pests, with a long duration of the control activity, and a method for controlling rice pests using the same, and the aforementioned rice pest control The manufacturing method of solid preparations. For example, in the solid preparation for controlling rice pests of the present invention, the field water treatment is carried out 2 to 5 weeks after rice transplantation, so that planthoppers and chilo suppressalis that cannot be fully controlled by the previous chemical treatment It becomes a one-time control, which also effectively reduces the labor of pesticide control applied to rice cultivation farmers and increases the harvest rate.

Claims (17)

A solid preparation for controlling rice pests, which contains at least one active ingredient selected from the group consisting of flupyrimin represented by the following formula (1) and its salts, a solid carrier, and a surfactant , And binding agent, and coated granules or extruded granules

. For example, the solid preparation for controlling rice pests of claim 1, which is a coated granule, and the solid carrier includes core particles and an extender. Such as the solid preparation for controlling rice pests of claim 2, wherein the particle diameter of the aforementioned nuclear particles is 63 μm-6 mm. The solid preparation for controlling rice pests according to claim 2 or 3, wherein the aforementioned nuclear particles are at least one selected from the group consisting of silica sand, granular calcium carbonate, diatomaceous earth particles, granular clay, and pumice . The solid formulation for controlling rice pests according to any one of claims 2 to 4, wherein the aforementioned extender is at least one selected from the group consisting of clay, calcium carbonate, kaolin, and silica. The solid formulation for controlling rice pests according to any one of claims 2 to 5, wherein the aforementioned binding agent is at least one selected from the group consisting of flowing paraffin, vegetable oil, polyethylene glycol, and polypropylene glycol. Such as the solid preparation for controlling rice pests of claim 1, which is an extruded granule, the solid carrier includes an extender, and the surfactant includes a granulation modifier and a collapse/dispersant. Such as the solid preparation for controlling rice pests of claim 7, wherein the aforementioned extender is at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silica and bentonite. The solid formulation for controlling rice pests according to claim 7 or 8, wherein the aforementioned granulation improving agent is selected from the group consisting of sodium lauryl sulfate, sodium dialkylsulfosuccinate and sodium alkylbenzene sulfonate At least one of them. Such as the solid formulation for controlling rice pests in any one of claims 7-9, wherein the aforementioned collapse and dispersing agent is selected from the group consisting of sodium lignosulfonate, calcium lignosulfonate, and sodium naphthalenesulfonate formalin condensation It is made of sodium polyacrylate, sodium polyoxyethylene alkyl ether sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate, and polyoxyethylene/polyoxypropylene polymer sodium sulfate At least 1 in the group. The solid preparation for controlling rice pests according to any one of claims 7 to 10, wherein the aforementioned binding agent is selected from polyvinyl alcohol, dextrin, sugars, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and At least one of the group formed by methyl cellulose. A method for controlling rice pests, which comprises applying an effective amount of a solid preparation for controlling rice pests according to any one of claims 1 to 11 to the group selected from the group consisting of rice pests, rice, soil, and field surface At least one of the steps. According to claim 12, the method for controlling rice pests, wherein the aforementioned rice pests are selected from at least one of the group consisting of planthoppers and Chilo suppressalis. According to claim 12 or 13, the method for controlling rice pests, wherein the aforementioned rice pests are pesticide-resistant pests. According to the method for controlling rice pests in any one of claims 12 to 14, wherein the effective amount of the solid preparation for controlling rice pests is 1 g-1 kg per 10 ares of cultivated land based on the amount of the effective ingredients. A method for manufacturing a solid preparation for controlling rice pests, which is the method for manufacturing a solid preparation for controlling rice pests according to any one of Claims 2 to 6, characterized by comprising: Adding the aforementioned binding agent, or the aforementioned binding agent and the aforementioned surfactant to the aforementioned core particles to make them wet to obtain the wetting step of the wet core particles, and Mixing the aforementioned active ingredient, the aforementioned surfactant and the aforementioned extender, or the aforementioned active ingredient and the aforementioned extender and pulverizing to obtain the first mixing and pulverizing step of mixing and pulverizing, and The step of mixing the wet core particles and the first mixed and pulverized product to obtain a coated granule in which the surface of the wet core particles is covered with the first mixed and pulverized product. A method for manufacturing a solid preparation for controlling rice pests, which is the method for manufacturing a solid preparation for controlling rice pests according to any one of Claims 7 to 11, which is characterized by comprising: Mix the aforementioned active ingredient, the aforementioned extender, and the aforementioned binder and pulverize, or mix the aforementioned active ingredient, the aforementioned extender, and the aforementioned binder with the aforementioned granulation modifier and/or the aforementioned collapse/dispersant and pulverize, and The mixing and pulverizing step of obtaining the second mixed and pulverized product, and Kneading the second mixed and pulverized product and water, or kneading the second mixed and pulverized product and water with the aforementioned granulation modifier and/or the aforementioned collapse and dispersant to obtain a kneaded product, and The step of forming the aforementioned kneaded mixture with an extrusion granulator to obtain extruded granules.