KR20220047968A - Solid formulation for controlling rice pests containing flupyrimin - Google Patents

Abstract

로 표시되는 플루피리민 및 그 염으로 이루어지는 군에서 선택되는 적어도 1종의 유효성분, 고체 담체, 계면활성제, 및 결합제를 포함하고, 피복형 입제 또는 압출형 입제인, 벼 해충 방제용 고형 제제.Formula (1):

A solid preparation for controlling rice pests, comprising at least one active ingredient selected from the group consisting of flupyrimine represented by and a salt thereof, a solid carrier, a surfactant, and a binder, which is a coated granule or an extruded granule.

Description

Solid formulation for controlling rice pests containing flupyrimin

The present invention relates to a solid preparation for controlling rice pests comprising flupyrimin, and more particularly, to a solid preparation for controlling rice pests, which are coated granules or extruded granules, and a method for controlling pests in rice using the same, and the rice It relates to a method for producing a solid preparation for controlling pests.

More than 90% of rice, the staple food in Asia, is produced in Asia, and in particular, China, India and Indonesia account for 60% of the world's production (Non-Patent Document 1). In rice cultivation (rice cultivation) in this area, yield loss due to damage from lepidopteran pests that eat above-ground parts and hemipteran pests that suck stem parts is a problem. causing enormous damage. Damage to rice production by pests and diseases rises to approximately 45% (Non-Patent Document 2), and in order to improve rice production, control of these rice pests is essential.

Currently, for these rice pests that occur at different times, control (system control) is carried out by using drugs effective for each pest separately or in combination, and when multiple treatments are performed, Labor costs and labor are required. In addition, the occurrence of pests with reduced sensitivity to existing drugs is a problem (Non-Patent Documents 3 and 4). In addition, existing drugs such as organophosphorus, carbamate, and synthetic pyrethroids are regulated due to their adverse effects on non-target organisms. Therefore, it is desired to create a new agent that has a wide versatility of control activity and a long duration, does not exhibit cross-resistance with existing drugs, and has little impact on the environment.

As a pest control agent, flupyrimin has an insecticidal effect against hemipteran pests such as hemiptera, or lepidopteran pests such as lepidoptera that occur in rice (paddy rice, etc.) It has been reported that the effect is low (Patent Document 1), and it is also reported that it can be used in combination with other insecticides and fungicides for controlling insects such as aphids and worms (Patent Document 2). However, there are still insufficient studies on specific formulation forms and methods of use in the practical situation of rice production, particularly the duration of control activity.

International Publication No. 2012/029672 International Publication No. 2013/129688

AMIS Market Database, Retrieved 20 September 2018, Internet, <URL: http://statistics. Amis-outlook.org/data/index.html> India Crop Protection Chemicals (Pesticides) Market-Growth, Trends and Forecast (2017-2022), Mordor Intelligence Report (December 2017) Pest Management Science, Vol. 73(6), 1169-1178(2017) Scientific Reports, (2018) 8:4586 | DOI:10.1038/s41598-018-22906-5

The present invention has been made in view of this situation, and for controlling harmful organisms, particularly rice pests, a novel solid preparation having a sufficiently long duration of control activity, a method for controlling pests in rice using the same, and the solid for controlling pests in rice An object of the present invention is to provide a method for preparing the formulation.

The present inventors have conducted intensive studies to solve the above problems, and as a solid preparation, at least one active ingredient selected from the group consisting of flupyrimine and a salt thereof, a specific solid carrier, a surfactant, and a binder are combined Therefore, it was found that the specific coating-type granules or extruded granules exhibited excellent control activity against rice pests, and that the control activity lasted particularly for a long period of time, leading to the completion of the present invention. That is, the present invention provides the following.

[One]

Formula (1):

A solid preparation for controlling rice pests comprising at least one active ingredient selected from the group consisting of flupyrimin and salts thereof, a solid carrier, a surfactant, and a binder represented by a coated or extruded granules.

[2]

The solid preparation for controlling rice pests according to [1], which is a coated granule, wherein the solid carrier contains nuclear particles and an extender.

[3]

The solid preparation for controlling rice pests according to [2], wherein the nuclear particles have a particle diameter of 62 µm to 6 mm.

[4]

The solid preparation for controlling rice pests according to [2] or [3], wherein the nuclear particles are at least one selected from the group consisting of silica sand, granular calcium carbonate, diatomaceous earth, granular clay, and pumice.

[5]

The solid preparation for controlling rice pests according to any one of [2] to [4], wherein the bulking agent is at least one selected from the group consisting of clay, calcium carbonate, kaolin, and silicon dioxide.

[6]

The solid preparation for controlling rice pests according to any one of [2] to [5], wherein the binder is at least one selected from the group consisting of liquid paraffin, vegetable oil, polyethylene glycol, and polypropylene glycol.

[7]

The solid preparation for controlling rice pests according to [1], which is an extruded granule, the solid carrier contains an extender, and the surfactant contains a granulation improving agent and a disintegrating/dispersing agent.

[8]

The solid preparation for controlling rice pests according to [7], wherein the bulking agent is at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silicon dioxide, and bentonite.

[9]

The solid preparation for controlling rice pests according to [7] or [8], wherein the granulation improving agent is at least one selected from the group consisting of sodium lauryl sulfate, sodium dialkylsulfosuccinate, and sodium alkylbenzenesulfonate.

[10]

The disintegrating and dispersing agent is sodium lignin sulfonate, calcium lignin sulfonate, sodium naphthalene sulfonate formalin condensate, sodium polyacrylate, sodium polyoxyethylene alkyl ether sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate The solid preparation for controlling rice pests according to any one of [7] to [9], which is at least one selected from the group consisting of sodium sulfate and polyoxyethylene/polyoxypropylene polymer.

[11]

The rice according to any one of [7] to [10], wherein the binder is at least one selected from the group consisting of polyvinyl alcohol, dextrin, saccharides, carboxymethyl cellulose sodium, hydroxypropyl methyl cellulose, and methyl cellulose. Solid formulations for pest control.

[12]

A rice pest comprising the step of applying an effective amount of the solid preparation for controlling rice pests according to any one of [1] to [11] to at least one selected from the group consisting of rice pests, rice, soil and paddy water surface. control method.

[13]

The method for controlling a rice pest according to [12], wherein the rice pest is at least one selected from the group consisting of aphids and rhododendrons.

[14]

The rice pest control method according to [12] or [13], wherein the rice pest is a drug-resistant pest.

[15]

The method for controlling rice pests according to any one of [12] to [14], wherein the effective amount of the solid preparation for controlling rice pests is 1 g to 1 kg per 10 ares of arable land in terms of the amount of the active ingredient.

[16]

A method for producing a solid preparation for controlling rice pests according to any one of [2] to [6], the method comprising:

a wetting step of adding and wetting the binder or the binder and the surfactant to the nuclear particles to obtain wet core particles;

a mixing and pulverizing step of mixing and pulverizing the active ingredient, the surfactant and the extender, or the active ingredient and the extender to obtain a first mixed pulverized product;

A method for producing a solid preparation for controlling rice pests, comprising a step of mixing the wet core particles and a first mixed pulverized product to obtain coated granules in which the surfaces of the wet core particles are coated with the first mixed pulverized material.

[17]

A method for producing a solid preparation for controlling rice pests according to any one of [7] to [11],

The active ingredient, the extender and the binder are mixed and pulverized, or the active ingredient, the extender, and the binder are mixed with the granulation improving agent and/or the disintegrating/dispersing agent and pulverized to obtain a second mixed crushed product. process and

a kneading step of kneading the second mixed pulverized product and water, or kneading the second mixed pulverized product and water with the granulation improving agent and/or the disintegrating/dispersing agent to obtain a kneaded product;

A method for producing a solid preparation for controlling rice pests, comprising the step of molding the kneaded product with an extrusion granulator to obtain an extruded granule.

According to the present invention, there is provided a novel solid formulation with a long duration of control activity for controlling harmful organisms, particularly rice pests, a method for controlling rice pests using the same, and a method for producing the solid formulation for controlling rice pests thing becomes possible

In addition, flupyrimine and/or a salt thereof (preferably an acid addition salt) does not exhibit cross resistance with other drugs, has high safety against non-target organisms, and exhibits sufficiently excellent control activity at a low concentration, According to the present invention, it becomes possible to sustain all of them particularly for a long period of time. For example, by treating the solid preparation of the present invention containing flupyrimin and/or an acid addition salt thereof as an active ingredient once, it occurs at different times and causes enormous damage to rice. It is also possible to suppress two or more types of rice pests including those at low density for a long period of time. Therefore, according to the present invention, the improvement of the yield of rice is expected, and the problems faced by existing drugs, such as a decrease in drug sensitivity, an effect on the environment, a continuity of the effect, an effect on a non-target organism, a reduction in the labor of agricultural workers, etc. It becomes possible to solve

Hereinafter, the present invention will be described in detail according to preferred embodiments thereof.

<Solid Formulation>

The present invention, the formula (1):

A solid preparation for controlling rice pests which is a coated granule or an extruded granule comprising at least one active ingredient selected from the group consisting of flupyrimin and salts thereof, a solid carrier, a surfactant, and a binder represented by , sometimes simply referred to as “solid formulation”).

According to one aspect of the solid formulation of the present invention,

There is provided a solid preparation (hereinafter, simply referred to as “coated granules” in some cases) which is a coated granule, wherein the solid carrier comprises nuclear particles and an extender. In addition, according to another aspect of the solid preparation of the present invention,

Extruded granules, wherein the solid carrier includes an extender, and the surfactant includes a granulation improving agent and a disintegrating/dispersing agent (hereinafter, simply referred to as “extruded granules”) is provided.

In addition, in the present invention, the "solid preparation for controlling rice pests" includes, in addition to the following preparations for insecticidal or weakening of rice pests, a preparation for removing rice pests from the following rice pests, and parasitics of rice pests on rice. an agent for preventing rice pests, and an agent for protecting rice from rice pests.

(flupyrimine)

Flupyrimin, an active ingredient according to the present invention, is a compound represented by Formula (1), that is, N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene] -2,2,2-trifluoroacetamide. Flupyrimine can be synthesized, for example, according to the manufacturing method described in International Publication No. 2012/029672 (Patent Document 1).

In addition, the salt of flupyrimine as the active ingredient according to the present invention is preferably an acid addition salt, and the acid addition salt of flupyrimine is more preferably an agrochemically acceptable acid addition salt. As said acid addition salt, hydrochloride, a nitrate, a sulfate, a phosphate, an acetate, etc. are mentioned.

As an active ingredient according to the present invention, flupyrimine and a salt of flupyrimine may be used alone or in combination of two or more.

(rice pest)

Rice pests in which the solid preparation of the present invention exhibits control activity include pests that can eat leaves, stems, roots, and ears of rice; Refers to pests that can suck the leaves, stems, and ears of rice. Although it does not specifically limit as such a rice pest, For example, As an agricultural or horticultural pest, For example, Lepidopteran (Lepidoptera) pests (Mythimna Separata, K. aenescens), Parnara guttata, Plusia festucae, Mythimna loreyi, Protodeltote distinguenda, Spodoptera depravata Etc.; Hymenoptera (Chilo suppressalis), Samhwamyungmoth (Scirpophaga incertulas, Sesamia inferens, Scirphophaga innotrysus, Chilo polych Chilo auricilius), Hemiptera pests (mildew) Aphids, such as aphids, barley beard aphid, rice root aphid, black stinging stink bug; cicadas such as locust caterpillar and lightning locust; Stink bugs such as stink bug, country spiny stink bug, pike stink bug, southern green stink bug, red-horned blind stink bug, etc.); etc.), mites (Steneotarsonemus spinki, etc.), thrips pests, locust pests (rice locust, hawksbill, ground dog, etc.), thrips pests (rice leaf oyster fly, rice stem oyster fly, Orseolia oryzae, etc.), thrips insect pests (rice thrips, rice thrips, etc.), plant parasitic nematodes (rice leaf nematode, Meloidogynae graminicola, etc.), and the like, and may be used alone or in combination of two or more. , half Insect pests, thrips pests, Diptera pests, and Coleoptera pests, and more preferably, include anthracites, chrysanthemums, and cicadas, and more preferably hyacinth moths, thrips moths, aphids, Examples of the locust locust, the locust larvae, and the lightning locust worm, and more preferably, among them, the locust larvae and the locust larvae.

Moreover, as said rice pest, Nicotinic acetylcholine receptor agonists, such as imidacloprid; GABA receptor agonistic compounds such as fipronil and ethiprole; It may be a drug-resistant pest made by lowering sensitivity to existing drugs, such as diamide compounds such as chlorantraniliprole.

(Other pest control agents)

As the solid preparation of the present invention, the active ingredient, flupyrimin and its salt, by itself, exhibits excellent control activity against the rice pests, so it is sufficient to include the flupyrimine and/or its salt, but other harmful substances By mixing with a biological control agent, it may exhibit more excellent control activity against more pests, and may further include other pest control agents. Examples of other pest control agents that can be included include insecticides (including acaricides and nematicides), fungicides, herbicides, and plant growth regulators, and specific agents include, for example, the Pesticide Manual (The Pesticide Manual) , 17th edition published by The British Crop Protection Council) and Shibuya Index (SHIBUYA INDEX, 2014, published by SHIBUYA INDEX RESEARCH GROUP). Among them, insecticides and fungicides are preferable as the other pest control agents.

Preferred examples of the other pest control agents include, for example, organic phosphoric acid ester compounds, carbamate compounds, nereistokine derivatives, organic chlorine compounds, pyrethroid compounds, benzoylurea compounds, juvenile hormone-like compounds, molting Hormone-like compounds, neonicotinoid compounds, neuronal sodium channel blockers, insecticidal macrocyclic lactones, γ-aminobutyric acid (GABA) antagonists, ryanodine receptor agonist compounds, insecticidal ureas, BT agents, insect hospitals Viral agents, polyether-based antibiotic substances, thiamine antagonists, and sulfa-folate antagonist combination agents, and the like can be given.

More specifically, as pesticides, acephate, dichlorvos, EPN, fenitrothion, fenamifos, prothiofos, propenofos, pyraclo Phos (pyraclofos) chlorpyrifos-methyl (chlorpyrifos-methyl), diazinon (diazinon), fosthiazate (fosthiazate), imicyafos (imicyafos), an organic phosphoric acid ester-based compound such as phorate (phorate); methomyl, thiodicarb, aldicarb, oxamyl, propoxur, carbaryl, fenobucarb, ethiophencarb carbamate-based compounds such as ethiofencarb, fenothiocarb, pirimicarb, carbofuran, carbosulfan, and benfuracarb; neristoxin derivatives such as cartap and thiocyclam; organic chlorine-based compounds such as dicofol and tetradifon; Permethrin, tefluthrin, cypermethrin, deltamethrin, cyhalothrin, fenvalerate, fluvalinate , pyrethroid compounds such as etofenprox, silafluofen, and cyhalothrin; benzoylurea-based compounds such as diflubenzuron, teflubenzuron, flufenoxuron, and chlorfluazuron; juvenile hormone-like compounds such as methoprene; molting hormone-like compounds such as chromafenozide; imidacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram, thiacloprid, dinotefuran, sulfoxa nicotinic acetylcholine receptor agonists such as sulfoxaflor, flupyradifurone, dichloromezotiaz, triflumezopyrim; diamide compounds such as flubendiamide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, and tetraniliprole; GABA receptor agonist compounds such as ethiprole, fipronil, pyrafluprole, pyriprole, broflanilide, fluxametamide ; Respiratory chain electron transport complex I inhibitory compounds such as pyridaben, fenpyroxymate, pyrimidifen, tebufenpyrad, and tolfenpyrad; respiratory chain electron transport complex II inhibitory compounds such as cyflumetofen, cyenopyrafen, and pyflbumide; respiratory chain electron transport complex III inhibitory compounds such as fluacrypyrim, acequinocyl, and flometoquin; ACCase inhibitory compounds such as spirodiclofen, spiromesifen, spirotetramat; and macrolide compounds such as spinosad, avermectin, milbemycin, spinetoram, lepimectin, and emamectin benzoate. .

In addition, other compounds include buprofezin, hexythiazox, amitraz, chlordimeform, ethoxazole, pymetrozine, bifenazate, flonicamid, chlorfenapyr, pyriproxyfen, indoxacarb, pyridalyl, pyrifluquinazone, Metaflumizone, hydramethylnon, triadomate, afidopyropen, renofluthrin, chloroprallethrin, cyhalodiamide ( cyhalodiamide), fluazaindolizine, epsilon-metofluthrin, epsilon-metofluthrin, epsilon-momfluorothrin, kappa-bifent kappa-bifenthrin, kappa-tefluthrin, fluhexafon, thioxazafen, momfluorothrin, heptafluthrin, pyriminost Robin (pyriminostrobin), cycloxaprid, isocycloseram, oxazosulfyl, tyclopyrazoflor, spiropidion, acinonapyr (acynonapyr), dim propyridaz (dimpropyridaz), organometallic compounds, dinitro compounds, organosulfur compounds, urea compounds, triazine compounds, and hydrazine compounds, and microorganisms such as BT agents and insect pathogens Water pesticides may also be used. Moreover, as said insecticide, these agrochemically acceptable acid addition salts are also mentioned.

As the insecticide, one of the above may be used alone or a combination of two or more types may be used. Among them, preferred insecticides include cartap, thiocyclam, phorate, and flubendiamide. ), chlorantraniliprole, cyantraniliprole, carbofuran, and fipronil.

More specifically, as a bactericide, for example, azoxystrobin (azoxystrobin), cresoxym-methyl (kresoxym-methyl), trifloxystrobin (triflooxystrobin), metominostrobin (metominostrobin), orysastrobin (orysastrobin), etc. strobilurin-based compounds; anilinopyrimidine-based compounds such as mepanipyrim, pyrimethanil, and cyprodinil; triadimefon, bitertanol, triflumizole, metoconazole, propiconazole, penconazole, flusilazole, azole compounds such as myclobutanil, cyproconazole, tebuconazole, hexaconazole, prochloraz, and simeconazole; quinoxaline-based compounds such as quinomethionate; dithiocarbamate compounds such as maneb, zineb, mancozeb, polycarbamate, and propineb; phenyl carbamate-based compounds such as diethofencarb; organochlorine-based compounds such as chlorothalonil and quintozene; benomyl, thiophanate-methyl, benzimidazole-based compounds such as carbendazole; phenylamide-based compounds such as metalaxyl, oxadixyl, ofurase, benalaxyl, furalaxyl, and cyprofuram; sulfenic acid-based compounds such as diclofluanid; copper-based compounds such as copper hydroxide and oxyquinoline copper; isoxazole-based compounds such as hydroxyisoxazole; organophosphorus compounds such as fosetyl-aluminium and tolclofos-methyl; N-halogenothioalkyl compounds such as captan, captafol, and folpet; dicarboxyimide-based compounds such as procymidone, iprodione, and vinclozolin; carboxyanilide compounds such as flutolanil, mepronil, furametpyr, thifluzamide, boscalid, and penthiopyrad; morpholine-based compounds such as fenpropimorph and dimethomorph; organotin compounds such as fenthin hydroxide and fenthin acetate; and cyanopyrrole compounds such as fludioxonil and fenpiclonil.

In addition, other compounds include tricyclazole, pyroquilon, carpropamid, diclocymet, fenoxanil, phthalide, flua Fluazinam, cymoxanil, triforine, pyrifenox, fenarimol, fenpropidin, phencicuron, ferimzone, cyazofamid, iprovalicarb, benthiavalicarb-isopropyl, iminoctadin-albesilate, cyflufenamid, cas kasugamycin, validamycin, streptomycin, oxolinic-acid, tebufloquin, probenazole, thiaelnil, isoti anil, isoprothiolane, tolprocarb, pydiflumetofen, picarbutrazox, mandestrobin, dipymetitrone, pyraziflumid, oxathiapiprolin, penflufen, fluoxapiprolin, florylpicoxamid, fluopimomide, iphenoquine (ipfenoquin), fluindapyr, isoflucypram, quinofumelin, methyltetraprole, pyridaclomethyl (pyridachlometyl), blood Lapropoin (pyrapropoyne), aminopyrifen (aminopyrifen), inpyrifluxam (inpyrifluxam), dicloventiazox (dichlobentiazox), and the like. Moreover, as said disinfectant|microbicide, these agrochemically acceptable acid addition salts are also mentioned.

As said bactericide, one of the above may be used alone or a combination of two or more types may be used. Among them, preferred bactericides include azoxystrobin, orysastrobin, thifluzamide, furametpyr ( furametpyr), phthalide, probenazole, acibenzolar-S-methyl, tiadinil, isotianil, isoprothiolane , tolprocarb, carpropamid, diclocymet, fenoxanil, tricyclazole, pyroquilon, ferimzone , tebufloquin, simeconazole, validamycin, Kasugamysicin, pencicuron, penflufen, dicloventiazox can be heard

(additive)

The solid preparation of the present invention can be prepared by using an additive (preferably an agrochemically acceptable additive) to the active ingredient, flupyrimin. Examples of the form include granules, and more specifically, they are coated granules or extruded granules containing a solid carrier, a surfactant, and a binder.

[Solid carrier]

Examples of the solid carrier include talc, bentonite, clay, kaolin, diatomaceous earth, vermiculite, zeolite, silicon dioxide, calcium carbonate, ammonium sulfate, silica sand, silica stone, and pumice stone.

The coated granule of the present invention contains nuclear particles and an extender in the solid carrier. In addition, it is preferable that the extruded granular material of the present invention contains an extender among the solid carriers and does not contain the nuclear particles, that is, the solid carrier consists only of the extender.

In the present invention, "nuclear particle" refers to a solid carrier having a particle diameter of 63 μm or more, and the particle diameter is preferably in the range of 63 μm to 6 mm, and is in the range of 75 μm to 2 mm. More preferably, it is still more preferable to exist in the range of 106 micrometers - 2 mm. The "particle diameter" of the nuclear particle or solid carrier according to the present invention is the diameter of a circle when the particle is projected onto a plane, and when the projection surface is not circular (the particle has a shape such as a plate shape, a plate shape, a rod shape, a polygon shape, etc.) ), refers to the diameter of the circumscribed circle. The nucleus particle is not particularly limited as long as it satisfies the above particle size, and examples thereof include granular, silica sand, diatomaceous earth, pumice, clay, calcium carbonate, and the like, and may be used alone or in combination of two or more. Further, in the present invention, in the granular calcium carbonate (granular calcium carbonate) and granular clay (granular clay), respectively, in addition to the particles that are pulverized products of each mineral, fine mineral powder with a small particle diameter is mixed with bentonite or the following binder, etc. Also included are particles that are granulated by kneading and kneading to granulate by extrusion granulation, crushing granulation, or the like.

In the present invention, "extending agent" is mainly used for the purpose of diluting the active ingredient, and specifically refers to a solid carrier having a particle diameter of less than 63 µm. The bulking agent is not particularly limited as long as it satisfies the above particle size, but in the coated granules, preferably, from the viewpoint of facilitating the grinding step in the following method for producing the coated granules, clay, calcium carbonate, kaolin And at least one selected from the group consisting of silicon dioxide. Moreover, in the said extruded granule, Preferably, it is at least 1 sort(s) selected from the group which consists of clay, talc, calcium carbonate, kaolin, silicon dioxide, and bentonite from the same viewpoint.

[Surfactants]

Examples of the surfactant include anionic surfactants, cationic surfactants, and nonionic surfactants.

As the surfactant contained in the coated granule of the present invention, among the above, those having a wetting action of the core particles are preferable, and specifically, for example, sodium ligninsulfonate, sodium lauryl sulfate, sodium naphthalenesulfonate sodium formalin condensation anionic surfactants such as water, sodium polyoxyalkylene alkyl ether sulfate, sodium alkylbenzene sulfonate, sodium dialkyl sulfosuccinate, sodium polyoxyalkylene styrene phenyl ether sulfate, and sodium polyoxyalkylene styrene phenyl ether phosphate; Polyoxyalkylene sorbitan fatty acid esters (such as polyoxyalkylene sorbitan monolaurate), sorbitan fatty acid esters, sucrose fatty acid esters, polyoxyalkylene castor oil, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene Nonionic surfactants, such as alkyl ether, polyoxyalkylene alkyl phenyl ether, polyoxyalkylene styryl phenyl ether, polyoxyethylene polyoxypropylene block polymer, and polyoxyalkylene alkylamine, are mentioned, 1 type of these It may be individual or a combination of 2 or more types may be sufficient. Among the surfactants, the nonionic surfactants or combinations thereof can be used for the same purpose as the binders described below in the coated granules of the present invention.

As used herein, "polyoxyalkylene" refers to one of polyoxyethylene and polyoxypropylene or a mixture thereof.

The extruded granule of the present invention contains a granulation improving agent and a disintegrating/dispersing agent among the surfactants.

In the present invention, "granulation improving agent" refers to one having an action of improving the familiarity of water and other components in the kneading step of the following production method among the surfactants, specifically, 0.1% aqueous solution At 25°C, a surfactant exhibiting a surface tension value of 10 to 35 mN/m is shown. The granulation improving agent is not particularly limited as long as it satisfies the above surface tension, but in the extruded granule, preferably, at least one selected from the group consisting of sodium lauryl sulfate, sodium dialkylsulfosuccinate, and sodium alkylbenzenesulfonate. 1 paper.

In the present invention, "disintegration/dispersing agent" refers to, among the surfactants, other than those corresponding to the granulation improving agent, and an action of improving at least one of dispersibility and disintegration property of the active ingredient with respect to other components indicates having Anionic surfactants are preferable as such disintegrating/dispersing agents, more preferably sodium ligninsulfonate, calcium ligninsulfonate, sodium naphthalenesulfonate formalin condensate, sodium polyacrylate, sodium polyoxyethylenealkylether sulfate, polyoxyalkylenestyrenephenylether sodium sulfate, sodium polyoxyalkylene styrene phenyl ether phosphate, polyoxyethylene polyoxypropylene polymer sodium sulfate, and these may be used individually by 1 type or in combination of 2 or more types.

[Binder]

In the present invention, the "binder" is mainly used for the purpose of increasing the strength of the solid preparation and/or strengthening the bonding between solid raw materials. Examples of the binder include cellulose derivatives such as sodium carboxymethylcellulose, hydroxypropylmethylcellulose or methylcellulose; polyacrylates such as sodium polyacrylate; polymethacrylates such as polymethyl methacrylate; polyvinyl derivatives such as polyvinyl alcohol and polyvinylpyrrolidone; gums such as xanthan gum, guar gum, and gum arabic (plant gums and the like); starch; dextrin; saccharides such as monosaccharides (fructose, glucose, galactose, etc.) and disaccharides (sucrose, maltose, lactose, etc.); glue; casein; gelatin; liquid paraffin; vegetable oils and fats such as soybean oil and rapeseed oil; Glycols, such as polyethyleneglycol and polypropylene glycol, are mentioned, One type alone or a combination of two or more types among these may be mentioned.

As a binder contained in the coating-type granule of this invention, at least 1 sort(s) selected from the group which consists of liquid paraffin, vegetable oil, polyethyleneglycol, and polypropylene glycol among the above is preferable. In addition, as the binder contained in the extruded granule of the present invention, among the above, at least one selected from the group consisting of polyvinyl alcohol, dextrin, saccharides, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, and methyl cellulose is preferable. .

[etc]

Moreover, as a solid preparation (preferably coated granule) of this invention, coloring agents, such as a red pigment and a blue pigment, can be contained further.

In addition, as the solid preparation of the present invention, within the range that does not impair the effects of the present invention, surfactants, emulsifiers, dispersants, disintegrants, wetting agents, spreading agents, thickeners, binders, antifreezing agents, antifoaming agents, coloring agents, At least one of other additives such as fungicides may be further included as needed.

[Furtherance]

The amount of active ingredient contained in the solid preparation of the present invention (flupyrimine or a salt thereof, if two or more types are included, the total amount thereof, hereinafter the same) is not particularly limited because it varies depending on the purpose of use or treatment method, Usually, it is 0.1 to 80 weight% in conversion of the free body of flupyrimine, Preferably it is 0.1 to 10 weight%.

The following are mentioned as a preferable aspect of the solid preparation of this invention.

(1) 0.1 to 10% by weight of flupyrimin, 20 to 98% by weight of nuclear particles (granular solid carrier such as silica sand), 0.2 to 30% by weight of each of extenders, surfactants and binders (more preferably 0.5 ~ 30% by weight), including, and a total of 100% by weight coated granules (Coated Granule),

(2) 0.1 to 10% by weight of flupyrimine, 0.5 to 30% by weight of each surfactant and binder, and 20 to 9 8% by weight of an extender (solid carrier), the total of which is 100% by weight. Extruded granules,

(3) 0.1 to 10% by weight of flupyrimine, 20 to 98% by weight of extender (solid carrier), 0.1 to 2.0% by weight of granulation improving agent, 0.5 to 5.0% by weight of disintegrating/dispersing agent, 0.5 to 30% by weight of binder Extruded granules in which the total is 100% by weight, including weight%.

<Method for Producing Solid Formulation>

The present invention is one aspect of the method for producing the solid preparation of the present invention,

a wetting step of adding and wetting the binder or the binder and the surfactant to the nuclear particles to obtain wet core particles;

a mixing and pulverizing step of mixing and pulverizing the active ingredient, the surfactant and the extender, or the active ingredient and the extender to obtain a first mixed pulverized product;

mixing the wet core particles and the first mixed pulverized product to obtain coated granules in which the surfaces of the wet core particles are coated with the first mixed pulverized material;

A manufacturing method comprising, (hereinafter referred to as "the manufacturing method of coated granules" in some cases), and,

Mixing and pulverizing the active ingredient, the extender and the binder, or mixing and pulverizing the active ingredient, the extender, and the binder with the granulation improving agent and/or the disintegrating/dispersing agent to obtain a second mixed pulverized product mixing and pulverizing process;

a kneading step of kneading the second mixed pulverized product and water, or kneading the second mixed pulverized product and water with the granulation improving agent and/or the disintegrating/dispersing agent to obtain a kneaded product;

A process of obtaining extruded granules by molding the kneaded material with an extruded granulator;

A manufacturing method (hereinafter, in some cases referred to as "manufacturing method of extruded granules"), including,

to provide.

[Method for producing coated granules]

The coated granule of the present invention is obtained by coating the surface of the core particle with the active ingredient and the extender with a binder to form granules. The nuclear particles are wetted in advance with a binder in order to be easy to coat (wetting process). In this wetting process, a surfactant (preferably a nonionic surfactant) may be additionally added. The wetting step is not particularly limited, and a conventionally known method or a method similar thereto can be appropriately employed. For example, a method of mixing while spraying the binder and, if necessary, the surfactant to the nuclear particles is mentioned. . As a binder at this time, it can also be used after dilution with solvents, such as water and ethanol.

On the other hand, the component to be coated is preliminarily added with an extender, uniformly mixed and pulverized. That is, the active ingredient, the surfactant, and the extender are mixed and pulverized (at least the active ingredient and the extender are pulverized) to obtain a first mixed pulverized product (mixing pulverization step). At this time, when the surfactant is added in the wetting step, the active ingredient and the extender are mixed and pulverized to obtain a first mixed pulverized product. As the surfactant, it may be used in two steps: a wet process and a mixing and pulverizing process. The grinding method is not particularly limited, and a conventionally known method or a method similar thereto can be employed as appropriate. For example, a method using an impact type crusher such as a pin mill or a hammer mill, or a method using an airflow type crusher such as a jet mill is mentioned. can

The above wet step and the mixing and pulverizing step may be performed first, or may be performed simultaneously. Then, the wet core particles and the first mixed pulverized product are mixed to obtain a coated granule in which the surfaces of the wet core particles are coated with the first mixed pulverized material. It does not restrict|limit especially also as such a mixing method, A conventionally well-known method or a method similar to it can be employ|adopted suitably, For example, Vessel rotary mixers, such as a concrete mixer; A method using a container fixed mixer such as a ribbon mixer or a conical screw mixer is exemplified.

The method for producing the coated granules may further include a drying step of drying the coated granules if necessary. It does not restrict|limit especially as such a drying method, A conventionally well-known method or a method similar to this can be employ|adopted suitably.

[Method for producing extruded granules]

The extruded granular material of the present invention is obtained by uniformly mixing and pulverizing the ingredients such as the active ingredient and the extender, adding water and kneading the mixture, and molding it to obtain granules. That is, first, the active ingredient, the extender, the granulation improving agent, the disintegrating/dispersing agent and the binder are mixed and pulverized (at least the active ingredient and the extender are pulverized) to obtain a second mixed pulverized product (mixed) grinding process). In such a mixing and pulverizing step, the granulation improving agent and/or the disintegrating/dispersing agent may not be added, but may be added in the next kneading step. As such a grinding method, the method similar to the grinding|pulverization method in the manufacturing method of a coated granule can be employ|adopted suitably. In addition, as a binder at this time, it can also be used as a solution phase by dissolving using solvents, such as water and ethanol.

Next, in the case where the second mixed pulverized product and water, or the granulation improving agent and/or the disintegrating/dispersing agent are not added in the pulverizing step, the second mixed pulverized product and water and the granulation improving agent and/or the disintegrating agent · The dispersant is kneaded (kneaded) to obtain a kneaded product. In addition, as the granulation improving agent and the disintegrating/dispersing agent, it may be used independently of each other by dividing it into two steps of a mixing and pulverizing step and a kneading step. The kneading method is not particularly limited, and a conventionally known method or a method corresponding thereto can be appropriately adopted. For example, a mixing kneader such as a ribbon mixer, a conical screw mixer, a Henschel mixer, a twin-arm kneader is used. method can be found.

Then, the kneaded material is molded by an extrusion granulator to obtain an extrusion granulator. There is no restriction|limiting in particular also as such a shaping|molding method, A conventionally well-known method or a method similar to this can be employ|adopted suitably. For example, as the extrusion granulator, a transverse extrusion type, a voltage extrusion type, a shoulder type, and a roller extrusion type are mentioned according to the extrusion structure, and the kneaded material is extruded from a screen or a die by applying pressure with a screw or roller, etc. how to do it

After molding the extruded granules, if necessary, a drying step of drying the extruded granules may be further included. It does not restrict|limit especially as such a drying method, A conventionally well-known method or a method similar to this can be employ|adopted suitably.

According to another preferred aspect of the present invention, as a combination, there is provided a combination of the first composition, which is a solid preparation of the present invention, and the second composition, which is a composition comprising another pest controlling agent as an active ingredient. In this case, the second composition may be in any dosage form with the addition of appropriate additives. The combination may be provided in the form of a medicament set.

According to another aspect of the present invention, there is provided a method for protecting rice from pests of rice, wherein the solid preparation of the present invention and at least one other pest control agent are simultaneously or separately (preferably treated) on a subject (area to be treated). Preferably, there is provided a method comprising applying each component simultaneously). In this method, "simultaneous" application includes mixing at least one of the solid formulation of the present invention and the other pest control agent prior to application to the subject and applying the mixture. When applied "individually", it includes application of the solid preparation of the present invention prior to the other ingredients, and application of the solid preparation of the present invention later than the other ingredients, without premixing them.

<Method for controlling rice pests>

The present invention provides a method for controlling rice pests (hereinafter, simply in some cases, simply referred to as "control methods").

In addition, in the present invention, in the "rice pest control method", in addition to the method of insecticidal or weakening of the rice pests, the following method of removing rice pests from rice, a method of preventing parasitism of rice pests on rice, rice a method of protecting rice from pests.

[rice]

Although it does not specifically limit as a plant which can apply the solid preparation of this invention, Rice (Oryza sativa, Oryzaglaberrima) is preferable. Rice is a plant of the genus Graeceae, and specifically, it is divided into two ecotypes, O. sativa subsp. japonica and O. sativa subsp. indica, and intermediate varieties by these hybridizations. Javanica rice is included in the Japonica species.

Rice is cultivated under various climatic conditions in a very wide area centered on the Asian monsoon zone. It is cultivated in the north from the Amur River on the border with Russia and China, and in the south across Argentina. mountainous regions of Nepal and India; It is cultivated by irrigation in the deserts of Pakistan, Iran and Egypt, and without irrigation in parts of Asia, Africa and Latin America. Moreover, in the delta zone of Asia, it is cultivated as floating rice.

According to the cultivation method, rice is divided into six provinces (陸稻) and water supply (水稻). The yukdo is sown directly in the field and cultivated in the field condition. There is also direct sowing cultivation by sowing directly in the faucet, but in Japan, the cultivation method in which the seedling is transplanted into the main field (root planting) is common.

The normal cultivation temperature is 20°C or higher, and water is grown in fresh water conditions (fabric fields). The minimum temperature for growth is 10~12℃, and 23℃ is required for flowering and fruiting. Conversely, when the temperature is about 35°C or higher, a high-temperature disturbance occurs.

Rice, which is originally an aquatic plant, is one of the crops with a large amount of water required, and without irrigation, drought damage occurs when the soil moisture is 10% or less in the surface layer and 12% or less in the subsoil. However, it is also cultivated in salt-rich soils, alkaline or acidic soils.

The solid preparation of the present invention can be applied in any period from sowing (preferably after transplantation) to harvest in rice cultivation, particularly preferably water cultivation. For example, 2 to 5 weeks after transplanting a seedling, by applying the solid preparation of the present invention to the water surface (field water surface) of the main field (sudo main field) after transplantation, it is possible to control the rice pests occurring at different times at once Do. Moreover, the water surface in hydroponic cultivation materials, such as a Wagnel pot, is also included in the said paddy water surface. The solid preparation of the present invention may be applied to the soil containing the cultivation carrier before transplantation, or the soil in which the meat is grown, etc., in addition to the water surface of the paddy field, and directly to the rice pests or rice (preferably the stem part). can be applied Among these, the target to which the solid preparation of the present invention is applied is preferably at least one of the above soil (cultivated soil and a cultivation carrier before transplantation, soil for cultivating yukdo, etc.) and the above-mentioned paddy water surface.

Moreover, in the control method of this invention, you may apply the said solid preparation as it is or diluted and applied so that the solid preparation of this invention may become an effective amount.

According to another aspect of the present invention, applying an effective amount of the solid preparation of the present invention to at least one selected from the group consisting of the rice pest, the rice (preferably stem part), the soil, and the water surface of the paddy field. A method of protecting rice from rice pests is provided, comprising:

Also, according to another aspect of the present invention, there is provided the use of the solid formulation of the present invention for protecting rice from rice pests.

As a method of applying the solid preparation of the present invention as a target, spray treatment, paddy water treatment, soil treatment (spreading, mixing, irrigation, etc.), etc. are mentioned, Preferably, full surface water treatment and soil treatment are used. can be heard

As a method of using the solid preparation of the present invention for total water treatment and soil treatment, the solid preparation may be sprayed on the surface of the paddy field or soil as it is, but after mixing with fertilizer or sand, an arbitrary amount can be applied to the field. may be As the treatment amount (that is, effective amount) in the case of application by total water treatment and soil treatment, the amount of the active ingredient in the solid preparation of the present invention (the amount in terms of free body of flupyrimine or a salt thereof, if two or more of these are included, these of 0.1 g to 10 kg, preferably 1 g to 1 kg, per 10 ares of arable land.

Moreover, it is although it does not specifically limit as a soil treatment method by the solid preparation of this invention, Preferably, the method of applying the solid preparation of this invention directly in soil or on the soil surface is mentioned. A more preferred method of soil treatment is application of spraying, strips, furrows and graft holes.

As another application method, the application of the solid formulation of the present invention to a nutrient solution in a nutrient solution cultivation system such as hydroponic cultivation such as thin-film hydroponics (NFT) or fresh solution hydroponics (DFT), and solid medium cultivation such as rock wool cultivation However, direct application to a solid medium containing an artificial soil containing vermiculite and an artificial mat for seedlings may be mentioned. Moreover, although it is not preferable from a viewpoint of continuing control activity for a long period, the solid preparation of this invention can also be applied by dispersing in water, or irrigating an emulsified or dissolved solution into soil.

As another application method, the application of the solid formulation of the present invention to a nutrient solution in a nutrient solution cultivation system such as hydroponic cultivation such as thin-film hydroponics (NFT) or fresh solution hydroponics (DFT), and solid medium cultivation such as rock wool cultivation However, direct application to a solid medium containing an artificial soil containing vermiculite and an artificial mat for seedlings may be mentioned. Moreover, although it is not preferable from a viewpoint of continuing control activity for a long period, the solid preparation of this invention can also be applied by dispersing in water, or irrigating an emulsified or dissolved solution into soil.

[Example]

Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to these Examples. In addition, all the raw materials of each formulation example used the commercial item. In addition, in each formulation example, the particle diameter is described only for the solid carrier (nuclear particle) whose particle diameter is 63 micrometers or more.

(Formulation example)

Formulation Example 1 [Extrusion-type granules]

flupyrimine 2% by weight

Sodium ligninsulfonate 3% by weight

Sodium Lauryl Sulfate 0.5% by weight

silicon dioxide 2% by weight

polyvinyl alcohol 1.5 wt%

clay 91 wt%

The components were uniformly mixed and pulverized, water was added and kneaded well, and then the kneaded product was passed through an extrusion granulator, and granulated and dried to obtain granules.

Formulation Example 2 [Extrusion-type granules]

flupyrimine 2% by weight

Sodium ligninsulfonate 3% by weight

Sodium Alkylbenzenesulfonate 0.5% by weight

silicon dioxide 2% by weight

polyvinyl alcohol 1% by weight

clay 91.5 wt%

The components were uniformly mixed and pulverized, water was added and kneaded well, and then the kneaded product was passed through an extrusion granulator, and granulated and dried to obtain granules.

Formulation Example 3 [Extrusion-type granules]

flupyrimine 2% by weight

sodium polyacrylate 2% by weight

Sodium dialkylsulfosuccinate 0.3% by weight

Sodium Carboxymethylcellulose 1.5 wt%

calcium carbonate 94.2 wt%

Except for sodium polyacrylate, the above components were uniformly mixed and pulverized, and sodium polyacrylate and water were added thereto and kneaded well, and then the kneaded product was passed through an extruded granulator and granulated and dried to obtain granules.

Formulation Example 4 [Extrusion-type granules]

flupyrimine 2% by weight

Sodium ligninsulfonate 3% by weight

Sodium Alkylbenzenesulfonate 0.3% by weight

dextrin 5% by weight

kaoline 10% by weight

clay 79.7% by weight

The components were uniformly mixed and pulverized, water was added and kneaded well, and then the kneaded product was passed through an extrusion granulator, and granulated and dried to obtain granules.

Formulation Example 5 [Extrusion-type granules]

flupyrimine 2% by weight

Sodium naphthalenesulfonate formalin condensate 3% by weight

Sodium Lauryl Sulfate 0.3% by weight

Carboxymethylcellulose sodium 1.5 wt%

talc 30% by weight

calcium carbonate 63.2 wt%

The components were uniformly mixed and pulverized, water was added and kneaded well, and then the kneaded product was passed through an extrusion granulator, and granulated and dried to obtain granules.

Formulation Example 6 [Coated granules]

flupyrimine 2% by weight

Silica sand (granular: 0.3-1.4 mm particle diameter) 95.55 wt%

Sodium Lauryl Sulfate 0.1% by weight

silicon dioxide 0.5% by weight

liquid paraffin 1.15 wt%

red pigment 0.2 wt%

kaoline 0.5% by weight

Components other than the silica sand and liquid paraffin were uniformly mixed and pulverized to obtain a pulverized product. After adding liquid paraffin to the silica sand to uniformly wet it, the above-mentioned pulverized material was added, mixed uniformly, and the pulverized material was coated on the core particles to obtain granules.

Formulation Example 7 [Coated granules]

flupyrimine 2% by weight

Silica sand (granular: 0.3-1.4 mm particle diameter) 95.85 wt%

Sodium Lauryl Sulfate 0.1% by weight

silicon dioxide 0.75 wt%

polypropylene glycol 1.1 wt%

red pigment 0.2 wt%

A pulverized product was obtained by uniformly mixing and pulverizing components other than the silica sand and polypropylene glycol. After adding polypropylene glycol to silica sand to wet it uniformly, the said pulverized material was added and mixed uniformly, the said pulverized material was coat|covered on the said core particle, and the granule was obtained.

Formulation Example 8 [Coated granules]

flupyrimine 2% by weight

Sodium Alkylbenzenesulfonate 0.1% by weight

kaoline 1% by weight

red pigment 0.2 wt%

polyethylene glycol 1.15 wt%

Granular calcium carbonate (particle diameter 0.42 to 0.85 mm) 95.55 wt%

Components other than the granular calcium carbonate and polyethylene glycol were uniformly mixed and pulverized to obtain a pulverized product. Polyethylene glycol was added to granular calcium carbonate and uniformly wetted, and then the pulverized product was added, mixed uniformly, and the pulverized material was coated on the core particles to obtain granules.

Formulation Example 9 [Coated granules]

flupyrimine 2% by weight

Sodium Alkylbenzenesulfonate 0.1% by weight

silicon dioxide 0.5% by weight

kaoline 0.5% by weight

blue pigment 0.2 wt%

polypropylene glycol 1.15 wt%

Silica sand (granular: 0.25-1.0 mm in particle size) 95.55 wt%

Components other than the silica sand and polypropylene glycol were uniformly mixed and pulverized to obtain a pulverized product. After polypropylene glycol was added to silica sand and wetted uniformly, the pulverized material was added and mixed uniformly to coat the pulverized material on the core particles to obtain granules.

Formulation Example 10 [Coated granules]

flupyrimine 2% by weight

kaoline 1.5 wt%

blue pigment 0.2 wt%

Sodium dialkylsulfosuccinate 0.1% by weight

Polyoxyalkylene sorbitan fatty acid ester 0.2 wt%

soybean oil 1% by weight

Silica sand (granular: 0.25-1.0 mm in particle size) 95% by weight

Flupyrimine, kaolin, and a blue pigment were uniformly mixed and pulverized to obtain a pulverized product. A mixture of sodium dialkylsulfosuccinate, polyoxyalkylene sorbitan fatty acid ester, and soybean oil mixed in advance with silica sand was added to wet uniformly, and then the pulverized material was added and uniformly mixed to coat the pulverized material on the core particles. thus obtained a tablet.

Comparative Formulation Example 1 [Floable Agent]

flupyrimine 10% by weight

Sodium ligninsulfonate 2.5% by weight

Sodium dialkylsulfosuccinate 0.2 wt%

propylene glycol 10% by weight

xanthan gum 0.3% by weight

Silicone-based antifoaming agent 0.5% by weight

Fungicide (organic nitrogen-sulfur compound, organic bromine compound) 0.03 wt%

water 76.47 wt%

Flupyrimin, sodium lignin sulfonate, sodium dialkylsulfosuccinate, propylene glycol, and a silicone-based antifoaming agent were added to water and mixed, followed by wet grinding by a bead mill to obtain a slurry (solution A). Next, xanthan gum, fungicides and water were mixed and dissolved to obtain an aqueous solution (solution B). 780 parts by weight of the prepared solution A and 230 parts by weight of the solution B were mixed to obtain a floorable agent.

Comparative Preparation Example 2 [Granule Wetting Agent]

flupyrimine 20% by weight

Sodium dialkylsulfosuccinate 1% by weight

Sodium ligninsulfonate 7% by weight

silicon dioxide 1% by weight

clay 71% by weight

The components were uniformly mixed and pulverized, water was added and kneaded well, and then the kneaded product was passed through an extruded granulator and granulated and dried to obtain wettable granules.

(Experimental Example 1 Farm test for worms and rhizomes)

In water packaging 25 days after planting, the granules of Formulation Example 1 (extrusion granules) are treated by sleeping application so that the amount of raw material (active ingredient amount, flupyrimine amount in the case of flupyrimine, hereinafter the same) is a predetermined amount. (Water treatment) was done. In the control formulation, similarly, after 25 days of planting, Cartab 4% granules, a preparation for controlling worms, were treated by sleep application so that the amount of the raw material (Cartab) was a predetermined amount, and 3 weeks (21 days) after the treatment. , The 25% buprofezin floatable agent, which is a preparation for controlling locusts, was treated by foliar spraying so that the amount of the raw material (bupropezin amount) was a predetermined amount. For the untreated group, neither agent was applied.

After 14, 21, 28, and 35 days of the treatment day (25 days after rice planting), the number of tillers at 20 weeks randomly selected from each group, and the number of stems damaged by the worms (mainly, shamrock moth) was counted The damage stem ratio was computed according to the following formula|equation.

Damage stem ratio (%) = (Number of damaged stems on each treatment day/total number of tillers in 20 weeks) × 100

The results are shown in Table 1 below. In addition, after 14, 21, 28, 35, and 42 days, the number of solids (the sum of the number of adults and larvae) of the parasitoids (sum of the anthrax and the larvae) were counted and the number of the parasitoids of the 20 weeks randomly selected from each group were counted. number of parasites. The results are shown in Table 2 below.

Control effect on worms (dominant species Samhwa magnolia moth) Drug name raw body weight
(g/ha) Damage reduction rate (%) Number of days after granulation processing 14 21 28 35 flupyrimine tablets
(Extruded granules: Formulation Example 1) 100 0.20 0.14 0.20 0.62 Cartab granulated + bupropezin floorable * 500+250 0.43 0.27 0.41 1.57 unprocessed - 1.29 0.89 1.72 3.14 * Bupropezin floatable agent was treated by foliar spraying 21 days after granulation treatment

Control effect on the anthracites (shrike, locust) Drug name raw body weight
(g/ha) The number of parasites of the rhododendron (number of worms/week) Number of days after granulation processing 14 21 28 35 42 flupyrimine tablets
(Extruded granules: Formulation Example 1) 100 0 1.5 8.1 9.7 21.1 Cartab granulated + bupropezin floorable * 500+250 0 8.3 66.2 79.8 59.4 unprocessed - 0 13.9 95.3 91.2 144.7 * Bupropezin floatable agent was treated by foliar spraying 21 days after granulation treatment

As a result of the test, as shown in Tables 1 and 2, in the flupyrimine granules, which are the solid preparations of the present invention, at a treatment amount of 100 g / ha, not only exhibits a higher damage suppression effect than the control preparations on worms, It was confirmed to significantly suppress the number of parasites of the rhododendron. On the other hand, in the treatment group (system control treatment group) of the control agents Cartab granules and buprofezin floatable agent, the ratio of stem damage caused by worms was suppressed to be lower than that of the untreated group, but the decrease rate of the number of parasites of scorpionfish was small. , it was the result that the density suppression effect on the rhododendrons was low. As described above, the flupyrimine granules of the present invention have long-term durability with only one treatment, and exhibit higher control activity against worms and scorpionfish than the systemic treatment of the control preparations, the preparation for controlling worms and the preparations for controlling worms. it was confirmed

In addition, by comparing the weight of rice harvested from each treatment group, the effect of each formulation on the yield of rice was evaluated. The results are shown in Table 3 below.

formulation raw body weight
(g/ha) Quantity (%)
(About the untreated group) flupyrimine tablets
(Extruded granules: Formulation Example 1) 100 112 Cartab granulated + bupropezin floorable 500+250 108 unprocessed - 100

As shown in Table 3, in the group treated with flupyrimine granules, the effect of improving the yield of 12% compared to the untreated group was recognized higher than the system control treatment group of the control agent. From the above results, according to the solid preparation (extruded granular preparation) of the present invention, it was confirmed that, by one treatment, not only reduced the effort of the rice pest control operation, but also exhibited a water-reducing effect superior to that of the control preparation.

(Test Example 2 Indoor test for oyster mushroom)

The rice 3 weeks after sowing was transplanted into the Wagnel pot (1/5000a), and 3 days after transplantation, the granules of Formulation Example 1 (extrusion type granules) or Formulation Example 6 (coated granules) so that the raw material amount became a predetermined amount. , Alternatively, the flupyrimine raw material was treated by sleep application (whole water treatment). For the untreated group, neither agent nor drug was applied. After 3, 29, and 42 days of the treatment or drug treatment (3 days after transplantation), 2nd instar larvae are released into each port, and the larvae are observed after 6 days or 7 days after the release, The corrected mortality rate was calculated according to the following formula.

Adjusted mortality rate (%) = [{(Number of living parasites in untreated group/Number of radioactive parasites)-(Number of live parasites in treated group/Number of radioactive parasites)}/(Number of live parasites in untreated group/Number of radioactive parasites)] × 100

The test was conducted with two flame retardants. The results are shown in Table 4 below.

Control Effect on Anchovy raw body weight
mg/mo Calibrated Mortality Rate (%) 3 days after treatment 29 days after processing 42 days after treatment Coated granules (Formulation Example 6) 0.4 100 100 71 Extruded granules (Formulation Example 1) 0.4 83 100 93 flupyrimine raw 0.4 100 50 50

As a result of the test, as shown in Table 4, in the coated granules and extruded granules of flupyrimin, which are the solid preparations of the present invention, even if rice pests are released after 29 and 42 days of each treatment, correction higher than the original flupyrimin The mortality rate was shown. Therefore, it was confirmed that what sets it as these granules was excellent in long-term persistence than the original body.

(Experiment Example 3 Farm Test for Caterpillars)

The granules (extrusion granules) of Formulation Example 1 were mixed with an appropriate amount of sand, and then treated with water application (overall water treatment) uniformly so that the raw material amount became a predetermined amount in a water pad 25 days after transplantation. In addition, on the same day, the flowable agent of Comparative Preparation Example 1 was diluted with water so that the treated water amount was 40 L/10a, and the leaves were spray-treated with a sprayer so that the raw material amount became a predetermined amount. For the untreated group, neither agent was applied. No damage was observed on the stems by the worms (dominant species Samhwa mungchung) during treatment with the preparation, but after 28 and 42 days of treatment, the number of stems in each state and planting heights caused by worms (dominant species Trifolium mite) were observed. , pure dryness) the number of stems was visually counted. 30 weeks of investigation were performed per group of 25 m 2 , and the damage stem ratio was calculated according to the following formula.

Damaged Stem Ratio (%) = {(Number of stems planted per 30 weeks)/(Total number of stems per 30 weeks)} × 100

The results are shown in Table 5 below.

Control effect on Myungchung (dominant species Samhwa Myungchung) formulation raw body weight
(g/ha) Damage reduction rate (%) 28 days after treatment 42 days after treatment Extruded granules (Formulation Example 1) 75 0.36 0.65 Flowable agent (comparative formulation example 1) 75 1.06 1.44 unprocessed - 1.63 2.40

As a result of the test, as shown in Table 5, the extruded granule of the present invention exhibited a higher control activity over a long period of time than the floorable agent against Myungchung (dominant species of Samhwamyungchung).

(Experiment 4　Farm test for white-backed locusts)

The granules (extrusion granules) of Formulation Example 1 were mixed with an appropriate amount of sand, and then treated with water application (overall water treatment) uniformly so that the raw material amount became a predetermined amount in a water pad 25 days after transplantation. In addition, on the same day, the flowable agent of Comparative Preparation Example 1 was diluted with water so that the treated water amount was 40 L/10a, and the leaves were spray-treated with a sprayer so that the raw material amount became a predetermined amount. For the untreated group, neither agent was applied. Parasitism on rice was not observed during the formulation treatment, but after 31, 49, and 56 days of each treatment, the number of adults and larvae parasitic on each main source were counted with the naked eye. The results of 30 weeks of irradiation per group of 25 m 2 are shown in Table 6 below as the number of parasites per week (sum of adults and larvae).

Control effect on white-backed beetle formulation raw body weight
(g/ha) Number of parasites (number of worms/week) 31 days after processing 49 days after processing 56 days after treatment Extruded granules (Formulation Example 1) 75 8.3 91.9 83.3 Flowable agent (comparative formulation example 1) 75 14.4 204.0 187.0 unprocessed - 56.5 295.1 299.1

As a result of the test, as shown in Table 6, the extruded granular agent of the present invention exhibited a higher control activity over a long period of time than the floatable agent, also against white locust.

(Reference Test Example Contrast test of granular wettable powder and floatable agent)

The flowable agent of Comparative Formulation Example 1 or the granular wettable powder of Comparative Formulation Example 2 was diluted with water to a treated water amount of 150 L/10a, and sprayed with a sprayer to the rice water leaves 48 days after transplantation so that the raw material amount became a predetermined amount dealt with For the untreated group, neither agent was applied. Before each treatment and 4, 7, 19, and 33 days after treatment, the parasitoids parasitized in each main circle were removed on an A4 size adhesive plate, and the number of adults and larvae were counted with the naked eye. The results of 30 weeks of irradiation per group of 24 m 2 are shown in Table 7 below as the number of parasites per week (sum of adults and larvae).

Control effect on larvae formulation raw body weight
(g/ha) Number of parasites (number of worms/week) before treatment process
4 days later process
after 7 days process
19 days later process
after 33 days granular wettable powder
(Comparative Formulation Example 2) 50 3.93 0.17 0.40 0.83 0.77 floorable
(Comparative Formulation Example 1) 50 3.63 0.07 0.50 0.67 0.93 unprocessed - 3.47 3.97 4.50 5.67 6.50

As a result of the test, as shown in Table 7, the flowable agent and the granular wettable powder exhibited the same level of control activity against the acromion. Therefore, from the above results, it can be said that the extruded granules of the present invention exhibit high control activity over a long period of time compared to wettable granules.

As described above, according to the present invention, a novel solid preparation with a long duration of control activity for controlling harmful organisms, particularly rice pests, a method for controlling pests in rice using the same, and the solid preparation for controlling pests in rice It becomes possible to provide a manufacturing method. For example, in the solid preparation for controlling rice pests of the present invention, by treating the entire surface with water 2 to 5 weeks after transplantation of rice, control of chrysanthemums and caterpillars, which could not be sufficiently controlled with a single chemical treatment in the prior art, can be achieved at once. It becomes possible, and it is effective also for the reduction of the effort required for the chemical|medical control of a rice-growing farmer, and improvement of a yield.

Claims (17)

Formula (1):
[Formula (1)]

A solid preparation for controlling rice pests comprising at least one active ingredient selected from the group consisting of flupyrimin and salts thereof, a solid carrier, a surfactant, and a binder represented by a coated or extruded granules. According to claim 1,
It is a coated granule, and the solid carrier comprises nuclear particles and an extender, a solid preparation for controlling rice pests. 3. The method of claim 2,
The particle diameter of the nuclear particles is 62 ㎛ ~ 6 mm, a solid formulation for controlling rice pests. 4. The method of claim 2 or 3
The solid preparation for controlling rice pests, wherein the nuclear particles are at least one selected from the group consisting of silica sand, granular calcium carbonate, diatomaceous earth, granular clay, and pumice. 5. The method according to any one of claims 2 to 4,
The bulking agent is at least one selected from the group consisting of clay, calcium carbonate, kaolin, and silicon dioxide, a solid preparation for controlling rice pests. 6. The method according to any one of claims 2 to 5,
The binder is at least one selected from the group consisting of liquid paraffin, plant oils and fats, polyethylene glycol, and polypropylene glycol, a solid preparation for controlling rice pests. According to claim 1,
Extruded granules, the solid carrier comprises an extender, and the surfactant comprises a granulation improving agent and a disintegrating dispersant, a solid formulation for controlling rice pests. 8. The method of claim 7,
The bulking agent is at least one selected from the group consisting of clay, talc, calcium carbonate, kaolin, silicon dioxide and bentonite, a solid preparation for controlling rice pests. 9. The method according to claim 7 or 8,
The granulation improving agent is at least one selected from the group consisting of sodium lauryl sulfate, sodium dialkylsulfosuccinate, and sodium alkylbenzenesulfonate, a solid preparation for controlling rice pests. 10. The method according to any one of claims 7 to 9,
The disintegrating dispersant is sodium lignin sulfonate, calcium lignin sulfonate, sodium naphthalene sulfonate sodium formalin condensate, sodium polyacrylate, sodium polyoxyethylene alkyl ether sulfate, polyoxyalkylene styrene phenyl ether sodium sulfate, polyoxyalkylene styrene phenyl ether sodium phosphate, and A solid preparation for controlling rice pests, which is at least one selected from the group consisting of polyoxyethylene/polyoxypropylene polymer sodium sulfate. 11. The method according to any one of claims 7 to 10,
The binder is at least one selected from the group consisting of polyvinyl alcohol, dextrin, saccharides, carboxymethyl cellulose sodium, hydroxypropyl methyl cellulose and methyl cellulose, a solid preparation for controlling rice pests. A step of applying an effective amount of the solid preparation for controlling rice pests according to any one of claims 1 to 11 to at least one selected from the group consisting of rice pests, rice, soil, and paddy surface, Rice pest control method. 13. The method of claim 12,
The method for controlling rice pests, wherein the rice pest is at least one species selected from the group consisting of rhododendrons and mites. 14. The method of claim 12 or 13,
The rice pests are drug-resistant pests, rice pest control method 15. The method according to any one of claims 12 to 14,
The effective amount of the solid formulation for controlling pests in rice is 1 g to 1 kg per 10 ares of arable land in the amount of the active ingredient, a method for controlling pests in rice. A method for producing a solid preparation for controlling rice pests according to any one of claims 2 to 6,
a wetting step of adding and wetting the binder or the binder and the surfactant to the nuclear particles to obtain wet nuclear particles;
a mixing and pulverizing process of mixing and pulverizing the active ingredient, the surfactant and the extender, or the active ingredient and the extender to obtain a first mixed pulverized product;
mixing the wet core particles and the first mixed pulverized product to obtain a coated granule in which the surface of the wet core particles is coated with the first mixed pulverized material;
A method for producing a solid formulation for controlling rice pests. A method for producing a solid preparation for controlling rice pests according to any one of claims 7 to 11,
The active ingredient, the extender and the binder are mixed and pulverized, or the active ingredient, the extender, and the binder are mixed with the granulation modifier and/or the disintegrant and pulverized to obtain a second mixed crushed product. ,
A kneading step of kneading the second mixed pulverized product and water, or kneading the second mixed pulverized product and water with the granulation improving agent and/or the disintegrating dispersant to obtain a kneaded product;
Comprising the step of molding the kneaded material with an extrusion granulator to obtain extruded granules,
A method for producing a solid formulation for controlling rice pests.