TW202100747A - 用於免疫治療之組合物及方法 - Google Patents

用於免疫治療之組合物及方法 Download PDF

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TW202100747A
TW202100747A TW108144827A TW108144827A TW202100747A TW 202100747 A TW202100747 A TW 202100747A TW 108144827 A TW108144827 A TW 108144827A TW 108144827 A TW108144827 A TW 108144827A TW 202100747 A TW202100747 A TW 202100747A
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population
cells
cell
cancer
car
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TW108144827A
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何佳平
孫哲
張永亮
林南靜
何妍
劉欣
李超
劉晶華
劉麗萍
連軍 沈
江鵬斐
曹衛
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中國大陸商亘喜生物科技(上海)有限公司
中國大陸商蘇州亘喜生物科技有限公司
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Publication of TW202100747A publication Critical patent/TW202100747A/zh

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GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
AU2019372673A1 (en) 2018-11-01 2021-05-27 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for T cell engineering
BR112022011795A2 (pt) 2019-12-20 2022-08-30 Instil Bio Uk Ltd Métodos para preparar e isolar uma população terapêutica de linfócitos e para tratar câncer em um indivíduo, população terapêutica de linfócitos, bolsa criopreservada, recipiente flexível, e, sistema para extração de linfócitos
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WO2017070042A1 (en) * 2015-10-20 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t cell populations using akt inhibitors
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US20210301255A1 (en) * 2018-09-10 2021-09-30 Atara Biotherapeutics, Inc. Methods for expanding antigen-specific car-t cells, compositions and uses related thereto
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