TW202023363A - A securing device - Google Patents

Abstract

The present invention provides a securing device, comprising a base and a cover. The base is provided with a first connection part. The cover has at least one chamber for accommodating an experimental animal. The cover has a head end adjacent to the head of the experimental animal and a tail end adjacent to the tail of the experimental animal. The cover is provided with at least one second connection part for being magnetically connected with the first connection part.

Description

Baoding device

The present invention relates to a holding device, especially a holding device for experimental animals in general animal experiments, which effectively fixes the experimental animals in a magnetic manner and is provided with a window and a heating device. The window allows the experimenter to effectively Blood is drawn from various parts of the experimental animals, tissues are collected, and medicines are injected; the heating device will increase the body temperature of the experimental animals and make the blood vessels become obvious for the experimenters to perform experimental operations.

Generally speaking, an experimental animal is an animal that is manufactured through artificial reproduction and genetic engineering technology, and has specific genetic information, and the production process is precisely controlled by humans for the production or experiment of specific medicines and biotechnology products. Nowadays, the fields of biotechnology and medicine invest a lot of resources in the research of animal experiments to effectively predict breastfeeding through the physiological and pharmacological effects of experimental animals on drugs or external physical or chemical stimuli such as bacteria, specific drugs or specific external environment. The response of animals to the same drugs or stimuli is used as the basis of clinical treatment in the hospital system.

The methods for evaluating the overall physiological condition of experimental animals in response to the physiological and pharmacological effects induced by the aforementioned pathogens, specific drugs or specific external environment are generally divided into conscious model and anesthetic model. The aforementioned awake mode is administered by means of feeding tube (Oral gavage), subcutaneous injection (Subcutaneous, SC), intraperitoneal injection (Intraperitoneal, IP), intramuscular injection (Intramuscular, IM), and intravenous injection (Intravenous, IV), or Stimulate reality by means of electric shock, heat or cold or specific environment Test the animals to observe their reactions. On the other hand, the animal experiment method in anesthesia mode is to infuse, inhale or administer anesthetic to the experimental animal, then fix it on the platform for simple operation and perform various physiological tests such as brain waves, heartbeat or blood pressure, etc., and then use artificial sampling or instrument monitoring The physiological and pharmacological reactions of drugs or specific environmental conditions to animals.

During the animal experiment in the awake mode or anesthesia mode, if the experimental design includes the aforementioned compulsive steps on the experimental animal and the animal is conscious or conscious, the experimental animal must be locked into the Baoding device for For experimental operations. However, the experimental animal itself is in a living state and the fixing effect of the holding device is not enough. Therefore, the conventional technology uses a pressing plate to press the body of the experimental animal; or, stick the devil and stick the corresponding fluff or hook with the devil. The buckle is arranged around the operating platform. In this way, the experimenter can place the experimental animal on the operating platform and use the corresponding villi and hooks of the devil to fix the limbs of the experimental animal. It is fixed on the operating platform in a prone position; or, in the experimental operation of the cylindrical box in the conventional technology, experimental animals injected with empirical drugs will often resist stubbornly and refuse to drill into the circle when they want to perform a second injection. The barrel-shaped box or the restlessness in the box may cause difficulty in the second injection. In other words, furthermore, under the condition that experimental animals often have to perform multiple injections or sampling actions, the pressure plates, fixed limbs, or barrel-shaped boxes used in the above-mentioned conventional techniques will all make the experiment It is difficult for personnel to effectively fix the experimental animal body at one time, which results in time-consuming and inefficient. In addition, whether it is submandibular or facial vein, saphenous vein, tail vein, orbital sinus, or Cardiac puncture for experimental animals, If it is not fixed, the collection may fail or even cause danger to the experimental animals and may have to be repeated many times. Therefore, the aforementioned conventional fixing method obviously needs to be improved.

Therefore, there is an urgent need to provide a Baoding device that allows experimental animals to be effectively fixed in position and is easy to operate, which facilitates the effective implementation of various experiments; and in order to overcome the problems caused by the aforementioned conventional technology, the present invention is born.

The purpose of the present invention is to provide a holding device that firmly combines the cover and the base of the holding device by magnetic force, so as to achieve the technical effect that the binding force is not only strong, and the size of the magnetic force can be adjusted according to the type of experimental animal, without the need for setting such as The conventional technology generally fixes the limbs of experimental animals or sets other complex fixing elements or structures in the Baoding device, which is simple in structure, convenient to manufacture and low in cost; with the segmented heating plate device, it can be used for different bodies of experimental animals. The surface (parts) is heated, so that the experimenter can effectively enter blood collection, intravenous injection and other experiments; by setting up different windows on the cover, it is convenient for the experimenter to conduct experiments on different body parts and the experimental animal itself can remain stable .

To achieve the foregoing objective, the present invention provides a holding device, which includes a base and a cover. The base is provided with a first joining part. The cover has at least one chamber for accommodating an experimental animal, the cover has a head adjacent to the head of the experimental animal and a tail adjacent to the tail of the experimental animal, and the cover is provided with at least one second joining part , Which is combined with the first coupling part by means of magnetic force.

In one embodiment, the head end of the cover body forms a vent hole, and the tail end of the cover body forms an opening for fixing the tail of the experimental animal.

In one embodiment, the cover has a bottom edge, the bottom edge includes at least a pair of mutually parallel sides, and the at least one pair of mutually parallel sides respectively extend to form an extension portion for respectively setting the at least one second combination.

In one embodiment, the cover has a bottom edge, and the second joining portion is disposed on the bottom edge.

In one embodiment, the cover has an inner surface, and the second coupling portion is provided on the inner surface.

In another embodiment, at least one of the first coupling portion and the second coupling portion is a magnet or an electromagnet device.

In one embodiment, the cover is formed with at least one operating window.

In one embodiment, the inner surface of the cavity is provided with a first heating element.

In one embodiment, the upper surface of the base is provided with a second heating element.

In order to have a more in-depth understanding of the features and functions of the present invention, detailed descriptions are given below with the help of implementation diagrams.

1‧‧‧Base

2‧‧‧Cover body

3‧‧‧The first joint

4‧‧‧Second Joint

5‧‧‧The first heating element

6‧‧‧Second heating element

7‧‧‧Power

11‧‧‧Upper surface

21‧‧‧Vent

22‧‧‧Open

23‧‧‧Bottom edge

24, 24’‧‧‧ side

241, 242‧‧‧Extension

25‧‧‧Inner surface

26‧‧‧Window

A‧‧‧Headend

B‧‧‧End

a‧‧‧ Chamber

Figure 1 is a schematic structural diagram of an embodiment of the holding device of the present invention.

Figure 2 is a schematic diagram of the use state of the embodiment of the holding device of the present invention.

Figure 3 is a schematic diagram of the use state of the embodiment of the holding device of the present invention.

Fig. 4 is a schematic front view of the use state of the embodiment of the holding device of the present invention.

Figure 5 is a schematic front view of another embodiment of the holding device of the present invention in the use state.

Figure 6 is a schematic front view of another embodiment of the holding device of the present invention in the use state.

Figure 7 is the mixing of the embodiment of the chlorine dioxide aqueous solution production system of the present invention Structure diagram of slot 41.

Figure 8 is a schematic structural diagram of another embodiment of the holding device of the present invention.

FIG. 9A is a photograph of the tail of the mouse after the mouse is fixed by the holding device of the present invention and heated by the first heating element 5 and the second heating element 6.

Fig. 9B is a bar graph showing the change of mouse body temperature with heating time after the mouse is fixed by the holding device of the present invention and heated by the first heating element 5 and the second heating element 6.

In order to have a more in-depth understanding of the features and functions of the present invention, the embodiments are used in conjunction with the drawings to describe in detail. The same symbols in each figure represent the same or equivalent elements.

Please refer to FIG. 1 of the present invention. An embodiment of the holding device of the present invention includes: a base 1 and a cover 2. The base 1 is provided with a first joint 3. The cover 2 has at least one cavity a for accommodating an experimental animal, and the experimental animal can be a rat, a mouse, and other medium and small mammals used in general animal experiments. In another embodiment, the holding device of the present invention can also be applied to large animals, but the magnetic part needs to be adjusted relative to the strength of the experimental animal, as described below.

Furthermore, the cover 2 is provided with at least one second coupling portion 4, and the second coupling portion 4 is combined with the first coupling portion 3 in a magnetic manner. In the embodiment of the holding device of the present invention, the first coupling portion 3 and the second coupling portion 4 have permanent or non-permanent magnetism. For example, the first bonding part 3 and the second bonding part include iron, steel, nickel, cobalt, and their compounds and alloys. In another embodiment, the magnetic properties of the first coupling portion 3 and the second coupling portion 4 can be generated by magnetic materials such as magnets or electromagnet devices. It can be seen that, as mentioned above, the first coupling portion 3 and the second coupling portion 4 have permanent or non-permanent magnetism. Therefore, the present invention can maintain such a configuration on the base 1 Stable bonding force with the cover 2. If strong magnetic force is required for small mammals, a strong magnet can be provided for both the first coupling portion 3 and the second coupling portion 4, and the manufacturing process is extremely simple. If the magnetic force that can be adjusted instantly is required, at least one of the first coupling portion 3 and the second coupling portion 4 can be provided with an electromagnet device. In other words, the present invention can also effectively utilize the characteristics of the electromagnet device to adjust the required magnetic force between the base 1 and the cover 2 in real time.

Please continue to refer to Figure 1. The cover 2 has a head A adjacent to the head of the experimental animal and a tail B adjacent to the tail of the experimental animal. The head A is formed with a vent 21 and the tail B is formed with a The opening 22 is used for fixing the tail of the experimental animal, and for breathing of the experimental animal, and convenient for the experimenter to draw blood from the tail of the experimental animal.

Please refer to Figures 1, 2, and 4. In one embodiment, the cover 2 has a bottom edge 23. The bottom edge 23 includes at least a pair of parallel sides 24, 24'. The sides 24 and 24' respectively extend to form an extension portion 241, 242 for respectively providing the second coupling portion 4. In this embodiment, the four second coupling portions are located adjacent to the four corners of the cover 2 The parts 241 and 242 are used to enhance the effect of magnetic attraction between the cover 2 and the base 1. In another embodiment, a different number of second coupling parts can also be positioned at other parts of the extension parts 241 and 242, so as to adjust to the individual conditions of different experimental animals.

The cover 2 of the present invention is formed with at least one operating window. Please refer to Figure 3. In one embodiment, the cover 2 can be provided with a window 26 on the side and on the top. If the experimenter needs to perform specific experiments on specific parts of the experimental animal such as the back of the brain, abdomen, and limbs, for example , Cheek blood collection, saphenous vein blood collection, tail vein blood collection, orbital blood collection, heart blood collection, intraperitoneal injection, intramuscular injection, subcutaneous injection, intravenous injection, feeding tube feeding, etc., you can open these windows 26 for specific parts of experimental animals Carry out the aforementioned experimental operation, and the experimental animal can still be firmly fixed in The Baoding device of the present invention will not be disturbed to facilitate the experiment. Please refer to FIG. 8. In another embodiment, the cover of the present invention is further provided with a slidable operating window 26. In other words, the window 26 of the present invention can also have different design changes.

Please refer to FIG. 5. In another embodiment of the holding device of the present invention, the cover 2 has a bottom edge 23, and the second coupling portion 4 is provided at at least a part of the bottom edge 23. The advantage of this arrangement is that the overall cover 2 is more concise. Compared with the previous embodiment, the magnet provided on the second coupling portion 4 needs to be a powerful magnet or an electromagnet device, etc., in order to make small contact There is still enough magnetism on the surface that the experimental animals cannot escape.

Please refer to FIG. 6, in another embodiment of the holding device of the present invention, the cover 2 has an inner surface 25, and the second coupling portion 4 is provided on the inner surface 25. The reason for this arrangement is that the magnetic force on the side of the powerful magnet or electromagnet device is enough to generate the magnetic force that the experimental animals cannot escape. In another embodiment, the cover 2 of the present invention can also have a different shape, such as an arch as shown in FIG. 7, and the second coupling portion 4 is provided on the bottom edge 23 or the bottom edge 23 a part.

In one embodiment, please refer to Figures 1, 2, 4, 5, and 6 of the present invention. The inner surface 25 of the chamber a of the present invention is provided with a first heating element 5, which is activated by turning on a power supply 7. The first heating element allows the experimental animals to maintain their vitality due to proper heating during the experiment, and also allows the blood vessels of the experimental animals to expand properly. A second heating element 6 is provided under one of the upper surfaces 11 of the base 2, and the first bonding portion 3 is provided on the upper surface 11, which also allows the experimental animals to be properly adapted during the experiment. Warm up and maintain vitality. In another embodiment, the second heating element 6 can also be provided on the upper surface 11, and the first coupling portion 3 is provided under the upper surface 11. In another embodiment, at least one of the inner surface of the chamber a and the upper surface of the base can be energized in a manner of segmented energization, so as to meet various needs of experimental animals for heating and save energy. In another embodiment, referring to Figure 1, the heating plates on the left, right, and top of the inner surface of the chamber a can be independently energized heating plates. For example, when it is necessary to process the right forelimb of an experimental animal, it is only necessary to energize the heating plate on the right side instead of all the heating plates, so as to achieve the technical effect of energy saving. Please refer to Figure 9A of the present invention, which is a photo of the tail of the mouse after being fixed by the holding device of the present invention and heated by the first heating element 5 and the second heating element 6 for 3 minutes and 6 minutes Compared with before heating, the tail vein of mice has an increasingly obvious trend with time, so that the experimenter can get the needle. Please refer to Figure 9B of the present invention, which is a process of fixing 6 mice with the holding device of the present invention and heating them by the first heating element 5 and the second heating element 6 for 0, 3, 6, 9, 12 minutes The bar graph of mouse body temperature (measurement of rectal temperature) with heating time. According to the experimental results, the body temperature of mice heated for 3, 6, 9, 12 minutes is significantly different from that of unheated mice (t -test; 3 minutes: p<0.05; 6, 9, 12 minutes: p<0.001). From the experimental results, it can be seen that the holding device of the present invention can obviously increase the body temperature of the experimental animal and increase the blood circulation to cause the blood vessels to become obvious, so that the experimenter can conveniently perform the steps required for the experiment.

Therefore, the present invention has the following advantages:

1. The invention uses the stable magnetic force of the magnet or the electromagnet device that can adjust the magnetic force to effectively adjust the strength of various types of experimental animals. The structure is simple and the manufacturing process is convenient. It does not need to use the conventional pressing plate, fixed limbs or barrel type. The structure is complicated like a box.

2. The heating plate of the present invention can adjust its energized heating part according to different experiments, and heat a body part of the experimental animal, which not only saves energy, but also expands the blood vessels of specific body parts, which is convenient for experimenters to collect blood. The steps are more convenient.

3. Experimenters can perform various experimental treatments on experimental animals through the windows provided by the present invention, which is extremely convenient and does not need to be fixed by other devices.

The above are the specific embodiments of the present invention and the technical means used. Many changes and corrections can be derived from the disclosure or teaching of this article. If equivalent changes are made according to the concept of the present invention, the resulting When the effect does not exceed the essential spirit covered by the specification and the drawings, it should be regarded as being within the technical scope of the present invention, and shall be explained first.

Based on the content disclosed above, the present invention clearly achieves the intended purpose of the invention, and provides a Baoding device with industrial utilization and practical value. There is no doubt that Yan filed an invention patent application in accordance with the law.

1‧‧‧Base

2‧‧‧Cover body

3‧‧‧The first joint

4‧‧‧Second Joint

5‧‧‧The first heating element

6‧‧‧Second heating element

7‧‧‧Power

11‧‧‧Upper surface

21‧‧‧Vent

22‧‧‧Open

24, 24’‧‧‧ side

241, 242‧‧‧Extension

25‧‧‧Inner surface

A‧‧‧Headend

B‧‧‧End

a‧‧‧ Chamber

Claims (9)

A holding device comprising: a base provided with a first coupling part; a cover having at least one chamber for accommodating an experimental animal, the cover having a head adjacent to the head of the experimental animal, and A tail end adjacent to the tail of the experimental animal is provided with at least one second coupling portion for coupling with the first coupling portion in a magnetic manner. The holding device described in item 1 of the scope of patent application, wherein the head end of the cover body forms a vent hole, and the tail end of the cover body forms an opening for fixing the tail of the experimental animal. As for the holding device described in claim 1, wherein the cover has a bottom edge, the bottom edge includes at least a pair of mutually parallel sides, and the at least one pair of mutually parallel sides respectively extend to form an extension portion for The at least one second coupling part is respectively provided. As for the holding device described in item 1 of the scope of patent application, the cover has a bottom edge, and the second coupling part is provided on the bottom edge. As for the holding device described in item 1 of the scope of patent application, the cover has an inner surface, and the second coupling portion is provided on the inner surface. For the holding device described in item 1 of the scope of patent application, at least one of the first coupling portion and the second coupling portion is a magnet or an electromagnet device. In the holding device described in item 1 of the scope of patent application, the cover is formed with at least one operating window. The Baoding device described in item 1 of the scope of patent application, wherein the inner surface of the chamber is provided with a first heating element. Such as the Baoding device described in item 1 of the scope of patent application, wherein the upper surface of the base is provided with a The second heating element.

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