CN212186764U - Securing device - Google Patents
Securing device Download PDFInfo
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- CN212186764U CN212186764U CN201922272563.7U CN201922272563U CN212186764U CN 212186764 U CN212186764 U CN 212186764U CN 201922272563 U CN201922272563 U CN 201922272563U CN 212186764 U CN212186764 U CN 212186764U
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- 238000010171 animal model Methods 0.000 claims abstract description 61
- 238000010438 heat treatment Methods 0.000 claims description 26
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- 238000002474 experimental method Methods 0.000 description 16
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- 230000000144 pharmacologic effect Effects 0.000 description 3
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
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- 238000006243 chemical reaction Methods 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
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- Housing For Livestock And Birds (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
The utility model provides a fixing device, which comprises a base and a cover body. The base is provided with a first combining part. The cover body is provided with at least one cavity for accommodating an experimental animal, the cover body is provided with a head end adjacent to the head of the experimental animal and a tail end adjacent to the tail of the experimental animal, and the cover body is provided with at least one second combining part for combining with the first combining part in a magnetic force mode.
Description
Technical Field
The utility model relates to a fixing device, in particular to a fixing device for experimental animals in general animal experiments, which effectively fixes the experimental animals in a magnetic force way and is provided with a window and a heating device, and the window enables experimenters to effectively draw blood, collect tissues, inject drugs and the like from each part of the experimental animals; the heating device can raise the body temperature of the experimental animal and further make the blood vessel obvious so as to facilitate the experimental operation of experimenters.
Background
Generally, an experimental animal is an animal which has specific genetic information and whose production process is artificially precisely controlled for the production or experiment of specific medicines, biotechnological products by artificial breeding, manufacturing an animal using genetic engineering techniques, and the like. The present technology and medicine field invests a lot of resources in animal experiments to treat drugs or external physical or chemical stimuli such as: the physiological and pharmacological actions caused by pathogenic bacteria, specific drugs or specific external environments and the like effectively predict the reaction of mammals under the same drugs or stimulation and serve as the basis of clinical treatment of a hospital system.
The methods for evaluating the overall physiological condition of the experimental animal responding to the physiological and pharmacological actions induced by the pathogens, specific drugs or specific external environments are generally classified into a conscious mode (conscous mode) and an anesthetic mode (anestic mode). The waking mode may be performed by feeding tube feeding (Oral gavage), Subcutaneous injection (SC), Intraperitoneal Injection (IP), Intramuscular Injection (IM), Intravenous Injection (IV), or stimulating the experimental animal by electric shock, cold or heat or specific environment to observe the response. On the other hand, the animal experiment method in the anesthesia mode is to perfuse, inhale or administer an anesthetic to an experimental animal, fix the experimental animal on a platform to perform various physiological tests such as brain waves, heartbeats or blood pressure after a simple operation, and monitor physiological and pharmacological reactions of a drug or a specific environmental condition on an animal body through artificial sampling or an instrument.
During the animal experiment in the waking mode or the anesthesia mode, if the experimental design includes the aforementioned compulsive step on the experimental animal and the experimental animal is in a conscious or semi-conscious state, the experimental animal needs to be closed in a holding device to facilitate the experimental operation. However, the experimental animal is in a living state, and the fixing effect of the fixing device is not enough, so that the prior art adopts a pressing plate to press the body of the experimental animal; or, the devil glue and the fluff part or the hook part which is matched with the devil glue and corresponds to each other are arranged around the operation platform, so that an experimenter can place the experimental animal on the operation platform and fix the four limbs of the experimental animal by utilizing the fluff part and the hook part which correspond to the devil glue so as to fix the experimental animal on the operation platform in a lying posture; or, in the prior art, when the cylindrical cartridge is used for experimental operation, and the experimental animal for empirical medicine injection is subjected to secondary injection, the difficulty of refusing to drill into the cylindrical cartridge or causing secondary injection due to restlessness in the cartridge is always resisted. In other words, under the condition that the experimental animal usually needs to perform multiple injections or sampling, the aforementioned pressing plate, the four-limb fixing or the barrel-shaped box body adopted in the prior art all make it difficult for the experimenter to effectively fix the experimental animal at one time, which results in time consumption and inefficiency. In addition, no matter whether the experimental animal is subjected to cheek blood sampling (sub-cheek or facial vein), Saphenous vein blood sampling (Saphenous vein), caudal vein blood sampling (Tail vein), Orbital blood sampling (Orbital sinus), or Cardiac blood sampling (Cardiac pulse), if the experimental animal is not fixed well, the acquisition may fail, and even the experimental animal may be dangerous and possibly need to be repeated for many times, so that the existing fixing mode obviously needs to be improved.
Therefore, it is necessary to provide a fixing device which can effectively fix the experimental animal to the fixed position and is simple to operate, thereby facilitating the effective implementation of various experiments; and in order to overcome the problems of the prior art, the utility model discloses a production.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a fixing device, which firmly combines a cover body and a base of the fixing device through magnetic force, so as to achieve the technical effects that the combination force is strong and the magnitude of the magnetic force can be adjusted according to the type of experimental animals, and the fixing of the four limbs of the experimental animals or the arrangement of other complex fixing elements or structures in the fixing device is not needed as in the prior art, the structure is simple, the manufacture is convenient and the cost is low; the heating sheet device in a sectional type can heat different body surfaces (parts) of experimental animals, so that experimenters can effectively take blood and intravenous injection experiments; through being equipped with different windows on the lid, let the experimenter be convenient for experiment and experimental animal itself can keep firm to different health positions.
To achieve the above object, the present invention provides a retaining device, which includes a base and a cover. The base is provided with a first combining part. The cover body is provided with at least one cavity for accommodating an experimental animal, the cover body is provided with a head end adjacent to the head of the experimental animal and a tail end adjacent to the tail of the experimental animal, and the cover body is provided with at least one second combining part for combining with the first combining part in a magnetic force mode.
In one embodiment, the head end of the cover forms a vent hole, and the tail end of the cover forms an opening for fixing the tail of the experimental animal.
In an embodiment, the cover has a bottom edge, the bottom edge includes at least one pair of parallel edges, and the at least one pair of parallel edges extend to form an extending portion for disposing the at least one second engaging portion.
In one embodiment, the cover has a bottom edge, and the second engaging portion is disposed on the bottom edge.
In one embodiment, the cover has an inner surface, and the second engaging portion is disposed on the inner surface.
In another embodiment, at least one of the first combining part and the second combining part is a magnet or an electromagnet device.
In one embodiment, the cover has at least one operation window formed therein.
In one embodiment, wherein the inner surface of the chamber is provided with a first heating element.
In one embodiment, the upper surface of the base is provided with a second heating element.
In order to further understand the features and functions of the present invention, the following detailed description is provided with the help of the embodiments and the accompanying drawings.
Drawings
Fig. 1 is a schematic structural view of an embodiment of a holding device of the present invention;
FIG. 2 is a schematic view of an embodiment of a retention device according to the present invention;
FIG. 3 is a schematic view of an embodiment of a retention device according to the present invention;
fig. 4 is a front view of a schematic view of a usage state of an embodiment of the present invention;
fig. 5 is a front view of a schematic view of a use state of another embodiment of the retention device of the present invention;
fig. 6 is a front view of a schematic view of a use state of another embodiment of the retention device of the present invention;
fig. 7 is a block diagram of a mixing tank 41 of an embodiment of the chlorine dioxide aqueous solution production system of the present invention;
fig. 8 is a schematic structural view of another embodiment of a retaining device of the present invention;
fig. 9 is a bar graph showing the change of the body temperature of the mouse with heating time after the mouse is fixed by the fixing device of the present invention and heated by the first heating member 5 and the second heating member 6;
for a better understanding of the features and functions of the present invention, reference should be made to the drawings, which are to be considered as forming a further part of the specification, and in which like reference characters designate like or equivalent parts throughout the several views.
Description of the reference numerals
First joint part 3
Second joint part 4
Power supply 7
Head end A
Tail end B
Chamber a.
Detailed Description
Referring to fig. 1 of the present invention, an embodiment of the securing device of the present invention includes: a base 1 and a cover 2. The base 1 is provided with a first combining part 3. The cover 2 has at least one cavity a for accommodating an experimental animal, which may be a small or medium mammal such as a rat or a mouse used in general animal experiments. In another embodiment, the retaining device of the present invention can also be applied to large animals, but the magnetic force needs to be adjusted relatively according to the force of the experimental animal, as described below.
The cover 2 is provided with at least one second combining portion 4, and the second combining portion 4 is combined with the first combining portion 3 in a magnetic manner. In an embodiment of the present invention, the first coupling portion 3 and the second coupling portion 4 have permanent or non-permanent magnetism. For example, the first joining portion 3 and the second joining portion include: iron, steel, nickel, cobalt and their compounds and alloys. In another embodiment, the magnetism of the first and second connecting portions 3 and 4 can be generated by a magnetic material such as a magnet or an electromagnet device. Therefore, as mentioned above, the first joining portion 3 and the second joining portion 4 have permanent or non-permanent magnetism. Therefore, the present invention can maintain the stable binding force between the base 1 and the cover 2. If a strong magnetic force is required to be applied to the small mammal, the first combining part 3 and the second combining part 4 can be provided with a strong magnet, so that the process is very simple. If the magnetic force needs to be adjusted in real time, at least one of the first combining part 3 and the second combining part 4 can be provided with an electromagnet device. In other words, the present invention can also effectively utilize the characteristics of the electromagnet device to adjust the magnetic force required between the base 1 and the cover 2 in real time.
With reference to fig. 1, the cover 2 has a head end a adjacent to the head of the experimental animal and a tail end B adjacent to the tail of the experimental animal, wherein the head end a is formed with a vent hole 21, and the tail end B is formed with an opening 22 for fixing the tail of the experimental animal, so as to respectively provide the breath of the experimental animal and facilitate the experimenter to draw blood from the tail vein of the experimental animal.
Referring to fig. 1, fig. 2 and fig. 4, in an embodiment, the cover 2 has a bottom edge 23, the bottom edge 23 includes at least one pair of parallel sides 24 and 24 ', the at least one pair of parallel sides 24 and 24' respectively extend to form an extending portion 241 and 242 for respectively disposing the second coupling portions 4, in the embodiment, the four second coupling portions are positioned on the extending portions 241 and 242 adjacent to four corners of the cover 2 to enhance the magnetic attraction effect between the cover 2 and the base 1. In another embodiment, a different number of second coupling portions can be positioned at other portions of the extension portions 241, 242, so as to adjust for different experimental animals.
The cover 2 of the present invention is formed with at least one operation window 26. Referring to fig. 3, in an embodiment, an operation window 26 may be respectively disposed on a side and an upper side of the cover 2, and if an experimenter needs to perform a specific experiment on a specific part of the experimental animal, such as hindbrain, abdomen and back, four limbs, for example, cheek blood collection, saphenous vein blood collection, tail vein blood collection, eye socket blood collection, heart blood collection, intraperitoneal injection, intramuscular injection, subcutaneous injection, intravenous injection, feeding tube feeding, etc., the operation windows 26 may be opened, and the above-mentioned experimental operation is performed on the specific part of the experimental animal, so that the experimental animal can still be stably fixed in the retention device of the present invention without moving about so as to perform the experiment. Referring to fig. 8, in another embodiment, the cover of the present invention further has a slidable operating window 26. In other words, the operating window 26 of the present invention may have different design variations.
Referring to fig. 5, in another embodiment of the retaining device of the present invention, the cover 2 has a bottom edge 23, and the second engaging portion 4 is disposed on at least a portion of the bottom edge 23. This arrangement has the advantage of making the whole cover 2 more compact, and compared with the previous embodiment, the magnet of the second joint portion 4 needs to be a strong magnet or an electromagnet device, so as to have a magnetic force enough for the laboratory animal to escape in a smaller contact surface.
Referring to fig. 6, in another embodiment of the retaining device of the present invention, the cover 2 has an inner surface 25, and the second engaging portion 4 is disposed on the inner surface 25. The reason for this is that the magnetic force from the side of the powerful magnet or electromagnet device is sufficient to generate a magnetic force that the laboratory animal cannot escape. In another embodiment, the cover 2 of the present invention can also be in different shapes such as the arch shape shown in fig. 7, and the second combining portion 4 is disposed on the bottom edge 23 or a portion of the bottom edge 23.
In an embodiment, referring to fig. 1, 2, 4, 5 and 6 of the present invention, the inner surface 25 of the chamber a of the present invention is provided with a first heating element 5, which is activated by turning on a power source 7 to maintain the activity of the experimental animal during the experiment due to proper heating and to properly expand the blood vessels of the limbs of the experimental animal. The second heating element 6 is arranged under the upper surface 11 of the base 2, and the first combining part 3 is arranged on the upper surface 11, so that the experimental animal can maintain vitality due to proper heating in the experiment process. In another embodiment, the second heating member 6 can also be disposed on the upper surface 11, and the first combining portion 3 is disposed below the upper surface 11. In another embodiment, at least one of the inner surface of the chamber a and the upper surface of the base can be powered by a sectional power supply, so as to meet various needs of the laboratory animal needing to be warmed and save energy. In another embodiment, referring to fig. 1, the left, right and top first heating members 5 of the inner surface of the chamber a are independently energizable heating sheets. For example, when the right front limb of the experimental animal needs to be treated, the right heating plate is electrified instead of all the heating plates, so that the technical effect of saving energy is achieved. Referring to fig. 9 of the present invention, in order to fix 6 mice with the retaining device of the present invention, and to find a bar graph of the body temperature of the mice heated by the first heating element 5 and the second heating element 6 for 0, 3, 6, 9, and 12 minutes (measuring the anal temperature) along with the change of the heating time, the experimental results show that the body temperature of the mice heated for 3, 6, 9, and 12 minutes is significantly different from the body temperature of the mice not heated (t-test; 3 minutes: p < 0.05; 6, 9, and 12 minutes: p < 0.001). According to the experimental results, the fixing device of the utility model can obviously increase the body temperature of the experimental animal and increase the blood circulation to cause the blood vessel to become obvious, so that the experimenter can conveniently carry out the required steps of the experiment.
Therefore, the utility model has the advantages of it is following:
1. the utility model discloses utilize the firm magnetic force of magnet or can adjust the electromagnet device of magnetic force size and effectively adjust to the strength of the experimental animals of various different grade types, simple structure, technology are convenient need not be complicated like the box body of current clamp plate, four limbs fixed or cask pattern.
2. The heating plate of the utility model can adjust the part of the power-on heating according to different experiments, and heat individual body parts of experimental animals, thereby not only saving energy, but also expanding blood vessels of specific body parts, and facilitating the steps of blood sampling of experimenters, and the like.
3. The experimenter accessible the utility model discloses each window that sets up carries out various experiments to the experimental animals and handles, very convenient and fix with other devices.
The foregoing is directed to embodiments of the present invention and techniques for implementing the same, and many modifications and variations are possible in light of the above teaching or teaching, and it is intended that all such modifications and variations be included within the scope of the invention.
Claims (9)
1. A restraint device, comprising:
a base, which is provided with a first combining part;
the cover body is provided with at least one cavity for accommodating an experimental animal, the cover body is provided with a head end adjacent to the head of the experimental animal and a tail end adjacent to the tail of the experimental animal, and the cover body is provided with at least one second combining part for combining with the first combining part in a magnetic force mode.
2. The retaining apparatus of claim 1, wherein the head end of the cover defines a vent hole and the tail end of the cover defines an opening for securing a tail of a laboratory animal.
3. The retaining apparatus of claim 1, wherein the cover has a bottom edge, the bottom edge includes at least one pair of parallel edges, and the at least one pair of parallel edges extend to form an extension portion for disposing the at least one second engaging portion.
4. The retention device of claim 1, wherein the cover has a bottom edge, and the second engagement portion is disposed on the bottom edge.
5. The retention device of claim 1, wherein the cover has an inner surface and the second engagement portion is disposed on the inner surface.
6. The retention device of claim 1, wherein at least one of the first and second engaging portions is a magnet or electromagnet arrangement.
7. The retention device of claim 1, wherein the cover defines at least one operating window.
8. The holding device of claim 1, wherein the interior surface of the chamber is provided with a first heating element.
9. The retaining apparatus of claim 1, wherein the upper surface of the base is provided with a second heating element.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW107145978A TWI685294B (en) | 2018-12-19 | 2018-12-19 | A securing device |
| TW107145978 | 2018-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212186764U true CN212186764U (en) | 2020-12-22 |
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ID=70413609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922272563.7U Active CN212186764U (en) | 2018-12-19 | 2019-12-17 | Securing device |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN212186764U (en) |
| TW (1) | TWI685294B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6789510B1 (en) * | 2003-05-30 | 2004-09-14 | Ru-Ping Lee | Animal restraining apparatus and animal experiment for using the same |
| CN203555852U (en) * | 2013-11-18 | 2014-04-23 | 菏泽学院 | Freely-capturing-and-fixing device of anatomical physiology experiment mouse |
| JP2016192920A (en) * | 2015-03-31 | 2016-11-17 | 国立大学法人徳島大学 | Limb fixture for animal, and limb fixing method for animal |
| CN105662636B (en) * | 2016-03-10 | 2018-05-15 | 苏州大学 | A kind of device for animal tail vein injections |
| JP2018064944A (en) * | 2016-10-18 | 2018-04-26 | 尚英 笠原 | Electrode device for laboratory animal electrocardiogram |
| TWM577649U (en) * | 2018-12-19 | 2019-05-11 | 張世霖 | Restraint device |
-
2018
- 2018-12-19 TW TW107145978A patent/TWI685294B/en active
-
2019
- 2019-12-17 CN CN201922272563.7U patent/CN212186764U/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI685294B (en) | 2020-02-21 |
| TW202023363A (en) | 2020-07-01 |
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