TW202005677A - Safety mechanism for microneedle injection having a medication receiving chamber with accurate filled medication dose and convenient and safe operation structure design which is suitable for being carried out and self injected - Google Patents

Abstract

The present invention relates to a safety mechanism for microneedle injection, generally comprising an outer barrel unit and an inner barrel unit. The outer barrel unit includes an outer barrel body, a microneedle element, and a lid. The outer barrel body has an end that is a closed end and an opposite end that is an open end. The microneedle element is coupled to an outside surface of the closed end of the outer barrel body. The closed end of the outer barrel body is formed with one or more holes corresponding to the microneedle element. An inside surface of the closed end of the outer barrel body is provided with a tubular protruding post having a medication receiving chamber. The lid is assembled to the open end of the outer barrel body and formed thereon with a middle hole. The inner barrel unit comprises an inner barrel body, a piston, and a hollow needle structure. The inner barrel body has an end that is a closed end and an opposite end that is an open end. The piston is assembled at the closed end of the inner barrel body. The closed end of the inner barrel body and the piston are both formed thereon with holes that are coaxial and in communication with each other. The hollow needle structure penetratingly assembly in the inner barrel body. A front end of the inner barrel body is assembled into the tubular protruding post of the outer barrel body and an opposite end penetrates through the middle hole of the lid. The hollow needle structure includes a hollow needle, a support piece arranged at an end of the hollow needle, and push seat mounted to a middle section of the hollow needle. The push seat is formed with at least one annular groove. Moreover, the outer barrel body and the inner barrel body are each formed, to a side surface thereof, with an elongate slot penetrating therethrough and corresponding to each other. A push member having an end formed with at least one protrusion is inserted through the elongate slots of the outer barrel body and the inner barrel body to have the protrusion at the front end of the push member inserted into the annular groove of the push seat mounted to the hollow needle in the inner barrel body, so that through pushing the push seat with the push member, the hollow needle is moved in an axial direction inside the inner barrel body. A spring is arranged at an inner side of the push seat so that the hollow needle is normally kept at an original position. An external end portion of the inner barrel body extended outside the lid of the outer barrel body is sleevingly assembled to a stop member. The stop member is formed with a notch into which the external end portion of the inner barrel body is sleeved. With a stop rim of the external end of the inner barrel body being constrained by the stop member, the inner barrel body is positioned.

Description

Safety mechanism for microneedle injection

The invention relates to a safety mechanism for microneedle injection, in particular to a microneedle design with painless injection, accurate injection dosage and convenient use.

As a result of the prosperity of industry and commerce, people’s pace of life is strained, and their health is affected. In addition, improper diets make the number of people with chronic diseases high, and patients with chronic diseases need daily injections of drugs for treatment and control of the disease, regardless of It is a chronic disease patient or a general patient. When receiving injection treatment, most of them use traditional large-diameter injection needles. The diameter of the pinhole is about 1mm and the needle length is about 1-3 cm. Therefore, the injection will puncture deep into the subcutaneous tissue and cause pain ( As shown in the seventh figure), the traditional injection needle not only brings pain to the patient, but the injection needle hole is more likely to increase the risk of infection.

Therefore, some companies have developed a microneedle syringe. Generally, the microneedle has a length of less than 3 cm and a small outer diameter. Therefore, it only penetrates into the dermis during injection, so it is less painful (as shown in the seventh figure). Although there are micro-needle injections on the market, they are arranged in a needle base with a large number of micro-needles, and then they are combined with traditional injection syringes. However, this design cannot use traditional injection syringes to fill the injection medicine. Obtaining an accurate dose of medicine is only suitable for injection by medical personnel, and is not suitable for carrying out, self-injection or injection requiring a fixed amount of medicine.

<Technical problem to be solved> In view of the practical difficulties and lack of improvement of the conventional injection needles and microneedle syringes mentioned above, the inventors hope to provide a breakthrough design to improve the practical effect. 3. Design and organization. It integrates its professional technical knowledge and practical experience engaged in the design and production and sales of related products for many years and the results obtained by research and design. Finally, a safety mechanism for microneedle injection of the present invention has been developed to provide users.

<Technical means to solve the problem> The present invention relates to a safety mechanism for microneedle injection, which mainly includes an outer barrel unit and an inner barrel unit, wherein the outer barrel unit includes an outer barrel body, a microneedle element and a cover One end of the outer cylinder body is a closed end and the other end is an open end. The microneedle element is combined with the outer side of the closed end of the outer cylinder body. The microneedle element includes a substrate and one or more microneedles located in the center of the substrate. One or more holes coaxial with the microneedles are provided at the closed end of the outer cylinder body, and the holes at the closed end are closed with a closed-end material such as silicone rubber, and a tubular convex column is provided on the inner surface of the closed end. A medicine accommodating chamber is formed in the convex column. The aforementioned cover body is combined with the open end of the outer cylinder body. A middle hole is provided on the cover body. The inner cylinder unit includes an inner cylinder body, a piston and a hollow needle structure. One end of the inner cylinder body is a closed end and the other end is an open end. The piston is arranged at the front end of the inner cylinder body. Both the closed end of the inner cylinder body and the piston are provided with coaxially communicating holes. The aforementioned hollow needle structure is worn through Assembled in the inner cylinder body, the front end of the inner cylinder body is combined into the tubular convex column of the outer cylinder body, and the other end passes through the middle hole of the cover body. The hollow needle structure includes a hollow needle and a support provided at the end of the hollow needle And a push seat provided in the middle section of the hollow needle, at least one ring groove is formed on the push seat, and at the same time, a long groove hole corresponding to each other is provided on the side of the outer cylinder body and the inner cylinder body. A pushing part of a convex part is inserted into the long slot of the outer cylinder body and the inner cylinder body, so that the convex part of the front end of the pushing part can be inserted into the ring groove of the pushing seat provided by the hollow needle in the body of the inner cylinder, and the pushing part can be pushed forward The seat makes the hollow needle move axially in the body of the inner cylinder, and is provided with a spring on the inner side of the sliding seat, so that the hollow needle is normally kept in the original position, and the inner cylinder body extends beyond the outer end of the outer cylinder body cover, set There is a stopper, the stopper has a gap for the inner end of the inner body of the inner cylinder, and the inner edge of the outer body of the inner cylinder is restricted by the stopper to position the inner body .

When the injection is to be carried out, first push in the pusher to fit the pusher seat, and push the pusher to make the pusher seat drive the hollow needle through the hole of the inner cylinder body and the piston, and puncture the closing of the hole provided at the closed end of the outer cylinder body After the material is used, the hollow needle is restored to its original position by the restoring force of the spring, and then the stopper is removed, and the end of the inner cylinder body is pushed to push the end of the cylindrical cylinder toward the closed end of the outer cylinder body. The air will be discharged by the hollow needle first, and then the front end piston will push the medicine in the medicine storage chamber through the closed end hole of the outer cylinder body to flow out of the micro needle through the closed end of the outer cylinder body for painless, safe and convenient use of the micro needle injection.

<Comparison with the efficacy of the prior art> The main purpose of the present invention is to have a medicine containing chamber for accurately filling the medicine dose, which can achieve the purpose of injecting a medicine that requires a certain amount.

The second object of the present invention is mainly to have a medicine storage room for accurately filling the dosage of medicine and a safe and convenient structure design, which does not require professional medical staff to perform injection, and is suitable for carrying out and self-injection.

In order to make your reviewer understand more about the structural features and functions of the present invention, the drawings and details will be described later.

Please refer to the first, second and third figures. The present invention relates to a safety mechanism for microneedle injection, which mainly includes an outer barrel unit (1) and an inner barrel unit (2), wherein the outer barrel unit (1) Including an outer cylinder body (11), a microneedle element (12) and a cover body (14), one end of the outer cylinder body (11) is a closed end (111), and the other end is an open end (13) The micro-needle element (12) is combined with the outer side of the closed end (111) of the outer cylinder body (11). The micro-needle element (12) includes a substrate (121) and one or more micro-devices located in the center of the substrate (121) The needle (122) is provided with one or more holes (114) coaxial with the micro-needle (122) at the closed end (111) of the outer cylinder body (11), and the hole (114) is closed with a sealing material such as silicone rubber On the inner surface of the closed end (111), a tubular convex column (112) is provided, and a medicine containing chamber (113) is formed in the tubular convex column (112), and the aforementioned cover body (14) is combined with the outer cylinder body (11) The open end (13) is provided with a middle hole (141) on the cover body (14). The inner cylinder unit (2) includes an inner cylinder body (21), a piston (22) and a hollow needle Structure, one end of the inner cylinder body (21) is a closed end (211), and the other end is an open end (23). The piston (22) is arranged at the front end of the inner cylinder body (21) and at the inner cylinder body (21) Both the closed end (211) and the piston (22) are provided with coaxially connected holes (212) (221). The aforementioned hollow needle structure is inserted into the inner cylinder body (21), and the front end of the inner cylinder body (21) is Combined into the tubular convex column (112) of the outer cylinder body (11), the other end passes through the middle hole (141) of the cover body (14). The hollow needle structure includes a hollow needle (24) and a hollow needle A support member (241) at the end of the needle (24) and a pushing seat (242) provided at the middle section of the hollow needle (24), at least one ring groove (2421) is formed on the outer edge of the pushing seat (242), and at the same time, the outer cylinder Each side of the body (11) and the inner cylinder body (21) is provided with a long slot (15) (25) corresponding to each other, and the pushing member (3) with at least one convex portion (31) at one end is formed by the outer cylinder The long slot (15) (25) of the body (11) and the inner cylinder body (21) is inserted, so that the convex portion (31) at the front end of the pushing member (3) can be inserted into the hollow needle (24) in the inner cylinder body (21) The ring groove (2421) of the pushing seat (242) is provided, and the pushing seat (242) can be pushed by the pushing member (3) to make the hollow needle (24) move axially in the inner cylinder body (21), and A spring (243) is provided on one side of the pushing seat (242), so that the hollow needle (24) is normally kept in its original position, and extends out of the outer end of the outer cylinder body (11) and the cover (14) of the inner cylinder body (21) , The set has a stopper (4), the stopper (4) has a gap (41) into which the outer end of the inner cylinder body (21) can be inserted, and the inner cylinder body (21 ) The blocking edge (26) provided at the outer end is restricted by the blocking member (4) to position the inner cylinder body (21).

When injecting, first insert the pushing member (3) to make the convex part (31) fit into the ring groove (2421) of the pushing seat (242), and push the pushing member (3) to make the pushing seat (242) drive the hollow needle (24) ) After passing through the holes (212) (221) of the inner cylinder body (21) and the piston (22), and puncturing the sealing material provided at the closed end (111) of the outer cylinder body (11) (114) (Figure 4), the hollow needle (24) is restored to its original position by the restoring force of the spring (243), then remove the stopper (4) (as shown in the fifth picture), and push the inner cylinder body (21) The end of the tube is pushed into the tubular convex column (112) of the closed end (111) of the outer cylinder body (11). At this time, the air in the medicine containing chamber (113) will first be discharged by the hollow needle (24), and then The pushing of the inner cylinder body (21) causes the front end piston (22) to flow the medicine in the medicine containing chamber (113) out of the micro needle (122) through the closed end (111) hole (114) of the outer cylinder body (11) , For painless, safe and convenient microneedle injection (as shown in the sixth figure).

The substrate (121) and the micro-needle (122) of the micro-needle element (12) are made of stainless steel 304 or 316 series. The size of the micro-needle (122) is approximately: 1.3-2.0mm high and 0.2-0.7 outer diameter mm, inner diameter 0.1-0.5mm, wall thickness 0.05-0.15mm.

The forming method of the microneedle element (12) may be any method of sheet metal deep drawing, metal electroforming, stamping or 3D printing.

To sum up, the present invention has a medicament accommodating chamber for accurately filling the dosage of medicine and a safe and convenient structure design, which does not require professional medical personnel to inject, and is a novel, progressive and available for industrial application The invention has actually met the requirements for granting an invention patent. You have filed a patent application in accordance with the law. Shang Qigui's examination committee can examine it in detail and grant the patent in this case as soon as possible.

However, the above are only the preferred embodiments of the present invention, which should not be used to limit the scope of the present invention. Any equivalent changes and modifications made according to the patent application scope of the present invention shall still belong to the present invention patent. Covered.

(1) ‧ ‧ ‧ outer cylinder unit (11) ‧ ‧ ‧ outer cylinder body (111) (211) ‧ ‧ ‧ ‧ closed end (112) ‧ ‧ ‧ tubular convex column (113) ‧ ‧ ‧ pharmaceutical storage chamber (114 ) (212) (221) ‧ ‧ ‧ hole (12) ‧ ‧ ‧ micro needle component (121) ‧ ‧ ‧ substrate (122) ‧ ‧ ‧ micro needle (13) (23) ‧ ‧ ‧ open end (14) ‧ ‧‧Cover body (141) ‧‧‧ Middle hole (15) (25) ‧‧‧Slotted hole (2) ‧‧‧Inner cylinder unit (21) ‧‧‧Inner cylinder body (22) ‧‧‧ 24) ‧‧‧ Hollow needle (241) ‧‧‧ Support piece (242) ‧‧‧Push seat (2421) ‧‧‧ Ring groove (243) ‧‧‧ Spring (26) ‧‧‧ Stop flange (3) ‧‧‧Pushing piece(31)‧‧‧Convex part(4)‧‧‧Stopping piece(41)‧‧‧Notch

The first figure is an exploded perspective view of one of the preferred embodiments of the present invention. The second figure is a combined perspective view of the present invention. The third figure is a sectional view of the present invention. The fourth figure is a cross-sectional view of an embodiment of the present invention when the hollow needle is inserted into the closed end hole of the outer cylinder body. The fifth figure is a perspective view of an embodiment of the present invention with the stopper removed. The sixth figure is a cross-sectional view of an embodiment of the present invention when the pusher is taken out and the inner cylinder body is pushed for microneedle injection. The seventh figure is a schematic diagram of the penetration depth of the microneedle and the traditional injection needle of the present invention into the skin during injection.

(11)‧‧‧Outer cylinder body

(111)‧‧‧Closed end

(12)‧‧‧Microneedle components

(121)‧‧‧Substrate

(122)‧‧‧Needle

(14)‧‧‧cover

(15)‧‧‧Long slot

(3)‧‧‧Transfer

(31)‧‧‧Convex

(4)‧‧‧stop

Claims (9)

A safety mechanism for microneedle injection includes: an outer cylinder unit and an inner cylinder unit, wherein the outer cylinder unit includes an outer cylinder body, a microneedle element and a cover body, and one end of the outer cylinder body It is a closed end and the other end is an open end. The micro-needle element is combined with the outer side of the closed end of the outer cylinder body. The micro-needle element includes a base plate and a micro needle in the center of the base plate. A hole coaxial with the needle, and the hole is closed with a sealing material. On the inner surface of the closed end, a tubular convex column is provided, and a medicine accommodating chamber is formed in the tubular convex column. The aforementioned cover is combined with the outer cylinder body The open end is provided with a middle hole in the cover body. The inner cylinder unit includes an inner cylinder body, a piston and a hollow needle structure. One end of the inner cylinder body is a closed end and the other end is an open end. The front end of the inner cylinder body is provided with coaxial holes on the closed end of the inner cylinder body and the piston. The hollow needle structure is inserted into the inner cylinder body, and the front end of the inner cylinder body is combined into the tubular protrusion of the outer cylinder body. Inside the column, the other end passes through the hole in the cover. A safety mechanism for microneedle injection as described in item 1 of the scope of the patent application, wherein the hollow needle structure includes a hollow needle, a support provided at the end of the hollow needle, and a pushing seat provided at the middle section of the hollow needle. At least one ring groove is formed on the outer edge of the seat, and at the same time, each side of the outer cylinder body and the inner cylinder body is provided with a long slot hole corresponding to each other, and the pushing member with at least one convex portion at one end is formed by the outer cylinder body and the inner cylinder body The long slot hole is inserted, so that the convex part of the front end of the pushing member can be inserted into the ring groove of the pushing seat provided by the hollow needle in the inner cylinder body, and then the pushing seat can be pushed by the pushing member to make the hollow needle move axially in the inner cylinder body And, there is a spring on the side of the push seat, so that the hollow needle is usually kept in the original position. A safety mechanism for microneedle injection as described in item 1 of the scope of the patent application, wherein the inner cylinder body protrudes from the outer end of the outer cylinder body cover, the set has a stopper, and the stopper has a stopper for the inner cylinder The notch inserted into the outer end of the body is restricted by the stopper provided by the stop edge provided on the outer end of the inner cylinder to position the inner cylinder body. A safety mechanism for microneedle injection as described in item 1 of the patent scope, wherein a plurality of microneedles can be provided on the substrate of the microneedle element. A safety mechanism for microneedle injection as described in item 1 of the scope of the patent application, wherein a plurality of holes through which the medicament is contained in the medicament accommodating chamber can be provided at the closed end of the outer cylinder body. The safety mechanism for microneedle injection as described in item 1 of the patent application scope, wherein the sealing material used for the hole provided at the closed end of the outer cylinder body may be silicone rubber. A safety mechanism for microneedle injection as described in item 1 of the patent application scope, wherein the substrate and microneedle head of the microneedle element are made of 304 or 316 series stainless steel. A safety mechanism for microneedle injection as described in item 1 of the patent application scope, in which the size of the microneedle is approximately: 1.3-2.0mm in height, 0.2-0.7mm in outer diameter, 0.1-0.5mm in inner diameter, and 0.05-0.15mm in wall thickness . A safety mechanism for microneedle injection as described in item 1 of the patent application scope, wherein the molding method of the microneedle element can be any method of sheet metal deep drawing, metal electroforming, stamping or 3D printing.

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