TW202005635A - A moisturizing composition of skin and the method for beauty skin thereof - Google Patents
A moisturizing composition of skin and the method for beauty skin thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Description
本發明係提供一種皮膚保溼組合物及其美容皮膚的方法。該皮膚保溼組合物包含：一肌肽或肌肽衍生物，一具有複數個甜菜鹼之官能基的聚合物和一溶媒。特別地，以該皮膚保溼組合物的總重量計，該肌肽或肌肽衍生物所佔的重量百分比是0.001~40wt.%，和該具有複數個甜菜鹼之官能基的聚合物所佔的重量百分比是0.001~40wt.%。 The invention provides a skin moisturizing composition and a method for cosmetic skin. The skin moisturizing composition comprises: a carnosine or carnosine derivative, a polymer having a plurality of betaine functional groups and a solvent. In particular, based on the total weight of the skin moisturizing composition, the weight percentage of the carnosine or carnosine derivative is 0.001 to 40 wt.%, and the weight of the polymer having a plurality of betaine functional groups The percentage is 0.001~40wt.%.
習知的皮膚保濕產品的主成分是以玻尿酸或其鹽類為主。但玻尿酸的來源分為動物性(雞冠/chicken comb-derived)及微生物發酵(microbial fermentation)兩種。若屬動物性來源則可能引發過敏；若屬微生物發酵來源，其製程複雜，且易有製程不純物殘留在最終成品中；以上所述皆提高了其用在人體上的限制。特別是現在化妝保養品產業的要求和趨勢是原料必須是非動物性來源，且對原料的純度和安全性的要求更比照醫藥法規加以嚴格審查。此舉更提高了玻尿酸的取得難度和應用限制。 The main component of conventional skin moisturizing products is hyaluronic acid or its salts. But the sources of hyaluronic acid are divided into animal (chicken comb-derived) and microbial fermentation (microbial fermentation). If it is an animal source, it may cause allergies; if it is a microbial fermentation source, its process is complicated, and impure substances in the process are prone to remain in the final product; all of the above have raised its restrictions on human use. In particular, the current requirements and trends in the cosmetics and maintenance products industry are that the raw materials must be of non-animal origin, and the requirements for the purity and safety of the raw materials are more rigorously reviewed in accordance with pharmaceutical regulations. This move further increases the difficulty of obtaining hyaluronic acid and the application restrictions.
綜上所述，在現今的保養品產業亟須研究發展一種新的皮膚保濕組合物，以符合未來產業趨勢和配方需求。 In summary, in today's skin care industry, there is an urgent need to research and develop a new skin moisturizing composition to meet future industry trends and formulation needs.
鑒於上述之發明背景，為了符合產業上之要求，本發明之一目的在於提供一種皮膚保濕組合物，該皮膚保濕組合物包含具有至少一個甜菜堿的官能基的聚合物或共聚物，其中，該具有至少一個甜菜堿的官能基的聚合物包含：聚羧基甜菜堿、聚羧基甜菜堿的共聚物、聚磺基甜菜堿、聚磺基甜菜堿的共聚物、聚磷酸鹽甜菜堿、聚磷酸鹽甜菜堿的共聚物或其任一組合。 In view of the above background of the invention, in order to meet the requirements of the industry, an object of the present invention is to provide a skin moisturizing composition comprising a polymer or copolymer having at least one functional group of beetroot, wherein The polymer having at least one functional group of beetroot contains: polycarboxylated beetroot, copolymer of polycarboxylated beetroot, polysulfonated beetroot, copolymer of polysulfated beetroot, polyphosphate beetroot, polyphosphate Copolymer of beetroot or any combination thereof.
具體地，該皮膚保濕組合物更包含至少一肌肽或肌肽衍生物，該肌肽衍生物包含肌肽的鹽類、肌肽酯類、肌肽醯胺類或其任一組合，其中，該肌肽的鹽類包含肌肽鹽酸鹽、肌肽醋酸鹽、肌肽果酸鹽、肌肽鹼金屬族的鹽類、肌肽鹼土金屬族的鹽類或其任一組合。以該皮膚保濕組合物的總重量計，該肌肽或其衍生物所占的重量百分比是0.001~40wt.%，且/或該具有至少一個甜菜堿的官能基的聚合物的重量百分比是0.001~40wt.%。該具有至少一個甜菜堿的官能基的聚合物的重量平均分子量是2~1000kDa，且/或該聚磺基甜菜堿或其共聚物的重量平均分子量是10~500kDa。 Specifically, the skin moisturizing composition further comprises at least one carnosine or carnosine derivative, the carnosine derivative comprises carnosine salts, carnosine esters, carnosine amides or any combination thereof, wherein the carnosine salt comprises Carnosine hydrochloride, carnosine acetate, carnosine fruit acid salt, carnosine alkali metal group salts, carnosine alkaline earth metal group salts or any combination thereof. Based on the total weight of the skin moisturizing composition, the weight percentage of the carnosine or its derivative is 0.001 to 40 wt.%, and/or the weight percentage of the polymer having at least one beetroot functional group is 0.001 to 40wt.%. The weight average molecular weight of the polymer having at least one functional group of betaine is 2 to 1000 kDa, and/or the weight average molecular weight of the polysulfobetaine or its copolymer is 10 to 500 kDa.
具體地，該皮膚保濕組合物更包含至少一溶媒，該溶媒包含水、至少一多元醇、甘油或其任一組合，其中，該多元醇包含丙二醇、丁二醇或其任一組合。以該皮膚保濕組合物的總重量計，該具有至少一個甜菜堿 的官能基的聚合物或共聚物的重量百分比是0.01~20wt.%和該溶媒的重量百分比是80~99wt.%。 Specifically, the skin moisturizing composition further includes at least one vehicle, the vehicle includes water, at least one polyol, glycerin, or any combination thereof, wherein the polyol includes propylene glycol, butylene glycol, or any combination thereof. Based on the total weight of the skin moisturizing composition, the weight percentage of the polymer or copolymer having at least one beetroot functional group is 0.01-20 wt.% and the weight percentage of the solvent is 80-99 wt.%.
本發明之另一目的在於提供一種美容皮膚的方法，該美容皮膚的方法使用一種皮膚保濕組合物在哺乳動物的皮膚表面上，其中，該皮膚保濕組合物包含具有至少一個甜菜堿的官能基的聚合物或共聚物或其任一組合。該具有至少一個甜菜堿的官能基的聚合物包含：聚羧基甜菜堿、聚羧基甜菜堿的共聚物、聚磺基甜菜堿、聚磺基甜菜堿的共聚物、聚磷酸鹽甜菜堿、聚磷酸鹽甜菜堿的共聚物或其任一組合。該具有至少一個甜菜堿的官能基的聚合物的重量平均分子量是2~1000kDa，且/或該聚磺基甜菜堿或其共聚物的重量平均分子量是10~500kDa。 Another object of the present invention is to provide a method of cosmetic skin using a skin moisturizing composition on the skin surface of a mammal, wherein the skin moisturizing composition contains a functional group having at least one beetroot Polymer or copolymer or any combination thereof. The polymer having at least one beetroot functional group includes: polycarboxylated beetroot, a copolymer of polycarboxylated beetroot, polysulfonated beetroot, a copolymer of polysulfated beetroot, polyphosphate beetroot, polyphosphoric acid Copolymer of salt beetroot or any combination thereof. The weight average molecular weight of the polymer having at least one functional group of betaine is 2 to 1000 kDa, and/or the weight average molecular weight of the polysulfobetaine or its copolymer is 10 to 500 kDa.
具體地，該皮膚保濕組合物更包含至少一肌肽或肌肽衍生物，該肌肽衍生物包含肌肽的鹽類、肌肽酯類、肌肽醯胺類或其任一組合，其中，該肌肽的鹽類包含肌肽鹽酸鹽、肌肽醋酸鹽、肌肽果酸鹽、肌肽鹼金屬族的鹽類、肌肽鹼土金屬族的鹽類或其任一組合。以該皮膚保濕組合物的總重量計，該肌肽或其衍生物所占的重量百分比是0.001~40wt.%，且/或該具有至少一個甜菜堿的官能基的聚合物的重量百分比是0.001~40wt.%。 Specifically, the skin moisturizing composition further comprises at least one carnosine or carnosine derivative, the carnosine derivative comprises carnosine salts, carnosine esters, carnosine amides or any combination thereof, wherein the carnosine salt comprises Carnosine hydrochloride, carnosine acetate, carnosine fruit acid salt, carnosine alkali metal group salts, carnosine alkaline earth metal group salts or any combination thereof. Based on the total weight of the skin moisturizing composition, the weight percentage of the carnosine or its derivative is 0.001 to 40 wt.%, and/or the weight percentage of the polymer having at least one beetroot functional group is 0.001 to 40wt.%.
具體地，該皮膚保濕組合物更包含至少一溶媒，該溶媒包含水、至少一多元醇、甘油或其任一組合，其中，該多元醇包含丙二醇、丁二醇或其任一組合。以該皮膚保濕組合物的總重量計，該具有至少一個甜菜堿的官能基的聚合物或共聚物的重量百分比是0.01~20wt.%和該溶媒的重量百分比是80~99wt.%。 Specifically, the skin moisturizing composition further includes at least one vehicle, the vehicle includes water, at least one polyol, glycerin, or any combination thereof, wherein the polyol includes propylene glycol, butylene glycol, or any combination thereof. Based on the total weight of the skin moisturizing composition, the weight percentage of the polymer or copolymer having at least one beetroot functional group is 0.01-20 wt.% and the weight percentage of the solvent is 80-99 wt.%.
根據本發明之技術，所述之皮膚保溼組合物同時具有從環境中捕 捉水分和防止皮膚水分散失的雙重機制，因此能有效地提升皮膚保溼的效果，達到美容保養皮膚的目的。 According to the technology of the present invention, the skin moisturizing composition has a dual mechanism of capturing moisture from the environment and preventing skin water loss, so it can effectively improve the skin moisturizing effect and achieve the purpose of beauty and skin maintenance.
綜上所述，本發明之皮膚保溼組合物兼具從環境中捕捉水分和防止皮膚水分散失的雙重機制；且沒有使用動物性來源的成分，因而防範了保養品因添加動物性來源的玻尿酸而可能造成皮膚過敏的問題；更重要的是本發明之皮膚保溼組合物不具細胞毒性。因此，本發明之皮膚保溼組合物非常適合應用在皮膚保溼的美容保養領域。 In summary, the skin moisturizing composition of the present invention has a dual mechanism of capturing water from the environment and preventing skin water loss; and no ingredients of animal origin are used, thus preventing the maintenance product from adding hyaluronic acid of animal origin It may cause skin allergies; more importantly, the skin moisturizing composition of the present invention is not cytotoxic. Therefore, the skin moisturizing composition of the present invention is very suitable for application in the field of skin moisturizing beauty care.
有關本發明之前述及其他技術內容、特點與功效，在以下配合參考圖式之一較佳實施例的詳細說明中將可清楚的呈現。為了能徹底地瞭解本發明，將在下列的描述中提出詳盡的步驟及其組成。顯然地，本發明的施行並未限定於該領域之技藝者所熟習的特殊細節。另一方面，眾所周知的組成或步驟並未描述於細節中，以避免造成本發明不必要之限制。本發明的較佳實施例會詳細描述如下，然而除了這些詳細描述之外，本發明還可以廣泛地施行在其他的實施例中，且本發明的範圍不受限定，其以之後的專利範圍為準。 The foregoing and other technical contents, features and effects of the present invention will be clearly presented in the following detailed description with reference to one of the preferred embodiments of the drawings. In order to thoroughly understand the present invention, detailed steps and their composition will be presented in the following description. Obviously, the implementation of the present invention is not limited to the specific details familiar to those skilled in the art. On the other hand, well-known components or steps are not described in detail to avoid unnecessary limitation of the present invention. The preferred embodiments of the present invention will be described in detail below. However, in addition to these detailed descriptions, the present invention can be widely implemented in other embodiments, and the scope of the present invention is not limited, which is subject to the scope of the subsequent patent .
根據本發明的第一實施例，本發明提供一種皮膚保溼組合物，該皮膚保溼組合物包含：一肌肽或肌肽衍生物，一具有複數個甜菜鹼之官能基的聚合物和一溶媒；該具有複數個甜菜鹼之官能基的聚合物包含：聚羧 基甜菜鹼(poly(carboxybetaine))、聚羧基甜菜鹼(poly(carboxybetaine))的共聚物、聚磺基甜菜鹼(poly(sulfobetaihe))、聚磺基甜菜鹼(poly(sulfobetaine))的共聚物、聚磷酸鹽甜菜鹼(poly(phosphate betaine))、聚磷酸鹽甜菜鹼(poly(phosphate betaine))的共聚物或其任一組合。 According to the first embodiment of the present invention, the present invention provides a skin moisturizing composition comprising: a carnosine or carnosine derivative, a polymer having a plurality of betaine functional groups and a solvent; The polymer having a plurality of betaine functional groups includes: poly(carboxybetaine), copolymer of poly(carboxybetaine), poly(sulfobetaihe) , A copolymer of poly(sulfobetaine), a copolymer of poly(phosphate betaine), a copolymer of poly(phosphate betaine), or any combination thereof.
於一具體實施例，以該皮膚保溼組合物的總重量計，該肌肽或肌肽衍生物所佔的重量百分比是0.001~40wt.%，該具有複數個甜菜鹼之官能基的聚合物所佔的重量百分比是0.001~40wt.%。 In a specific embodiment, based on the total weight of the skin moisturizing composition, the weight percentage of the carnosine or carnosine derivative is 0.001 to 40 wt.%, and the polymer having a plurality of betaine functional groups accounts for The weight percentage is 0.001~40wt.%.
於一具體實施例，該肌肽衍生物包含肌肽的鹽類、肌肽酯類、肌肽醯胺類或其任一組合。 In a specific embodiment, the carnosine derivative comprises carnosine salts, carnosine esters, carnosine amides or any combination thereof.
於一具體實施例，該肌肽的鹽類包含肌肽鹽酸鹽、肌肽醋酸鹽、肌肽果酸鹽、肌肽鹼金屬族的鹽類、肌肽鹼土金屬族的鹽類或其任一組合。 In a specific embodiment, the carnosine salts include carnosine hydrochloride, carnosine acetate, carnosine fruitate, carnosine alkali metal salts, carnosine alkaline earth metal salts or any combination thereof.
於一具體實施例，該肌肽酯類是由一醇類和肌肽進行酯化反應所形成之化合物，該醇類的碳數是2~18。 In a specific embodiment, the carnosine esters are compounds formed by the esterification reaction between monoalcohols and carnosine, and the carbon number of the alcohols is 2-18.
於一具體實施例，該肌肽醯胺類是由一羧酸和肌肽進行醯胺化反應所形成之化合物，該羧酸的碳數是2~18。 In a specific embodiment, the carnosine amides are compounds formed by the amide amination reaction between a carboxylic acid and carnosine, and the carbon number of the carboxylic acid is 2-18.
於一具體實施例，該具有複數個甜菜鹼之官能基的聚合物的重量平均分子量是2~1000kDa。 In a specific embodiment, the weight average molecular weight of the polymer having a plurality of betaine functional groups is 2 to 1000 kDa.
於一具體實施例，上述之皮膚保溼組合物還包含一溶媒，該溶媒包含水、多元醇或其組合。該多元醇包含丙二醇、丁二醇、甘油或其組合物，較佳地，該丙二醇是1,3-丙二醇。 In a specific embodiment, the above skin moisturizing composition further includes a solvent, and the solvent includes water, polyol or a combination thereof. The polyol includes propylene glycol, butylene glycol, glycerin or a combination thereof. Preferably, the propylene glycol is 1,3-propanediol.
根據本發明的第二實施例，本發明提供一種皮膚保溼組合物，該皮膚保溼組合物包含一肌肽或其鹽酸鹽，一聚磺基甜菜鹼 (poly(sulfobetaine))或其共聚物和一溶媒，該溶媒包含水、丙二醇、丁二醇、甘油或其任一組合；以該皮膚保溼組合物的總重量計，該肌肽或其鹽酸鹽所佔的重量百分比是0.05~35wt.%，該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的重量百分比是0.05~35wt.%和該溶媒的重量百分比是30~99wt.%。 According to a second embodiment of the present invention, the present invention provides a skin moisturizing composition comprising a carnosine or its hydrochloride, poly(sulfobetaine) or a copolymer thereof And a solvent, the solvent comprises water, propylene glycol, butylene glycol, glycerin or any combination thereof; based on the total weight of the skin moisturizing composition, the weight percentage of the carnosine or its hydrochloride is 0.05~35wt .%, the weight percentage of the poly(sulfobetaine) or its copolymer is 0.05~35wt.% and the weight percentage of the solvent is 30~99wt.%.
於一具體實施例，該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的重量平均分子量是10~500kDa。 In a specific embodiment, the weight average molecular weight of the poly(sulfobetaine) or its copolymer is 10 to 500 kDa.
根據本發明的第三實施例，本發明提供一種皮膚保溼組合物，該皮膚保溼組合物包含一肌肽酯類或一肌肽醯胺類，一聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物和一溶媒，該溶媒包含水、丙二醇、丁二醇、甘油或其任一組合；以該皮膚保溼組合物的總重量計，該肌肽酯類或肌肽醯胺類所佔的重量百分比是0.05~20wt.%，該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的重量百分比是0.05~20wt.%和該溶媒的重量百分比是60~99wt.%。 According to a third embodiment of the present invention, the present invention provides a skin moisturizing composition comprising a carnosine ester or a carnosine amide, a polysulfobetaine (poly(sulfobetaine)) or The copolymer and a solvent, the solvent includes water, propylene glycol, butylene glycol, glycerin or any combination thereof; the weight of the carnosine esters or carnosine amides based on the total weight of the skin moisturizing composition The percentage is 0.05-20wt.%, the weight percentage of the poly(sulfobetaine) or its copolymer is 0.05-20wt.% and the weight percentage of the solvent is 60-99wt.%.
於一具體實施例，該肌肽酯類是由一醇類和肌肽進行酯化反應所形成之化合物，該醇類的碳數是2~18。 In a specific embodiment, the carnosine esters are compounds formed by the esterification reaction between monoalcohols and carnosine, and the carbon number of the alcohols is 2-18.
於一具體實施例，該肌肽醯胺類是由一羧酸和肌肽進行醯胺化反應所形成之化合物，該羧酸的碳數是2~18。 In a specific embodiment, the carnosine amides are compounds formed by the amide amination reaction between a carboxylic acid and carnosine, and the carbon number of the carboxylic acid is 2-18.
於一具體實施例，該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的重量平均分子量是10~500kDa。 In a specific embodiment, the weight average molecular weight of the poly(sulfobetaine) or its copolymer is 10 to 500 kDa.
根據本發明的第四實施例，本發明提供一種皮膚保溼組合物，該皮膚保溼組合物包含一聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物和一 溶媒，該溶媒包含水、丙二醇、丁二醇、甘油或其任一組合；以該皮膚保溼組合物的總重量計，該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的重量百分比是0.01~20wt.%和該溶媒的重量百分比是80~99wt.%。 According to a fourth embodiment of the present invention, the present invention provides a skin moisturizing composition comprising a poly(sulfobetaine) or its copolymer and a solvent, the solvent comprising water , Propylene glycol, butylene glycol, glycerin or any combination thereof; based on the total weight of the skin moisturizing composition, the weight percentage of the polysulfobetaine (poly (sulfobetaine)) or its copolymer is 0.01~20wt. % And the weight percentage of the solvent are 80~99wt.%.
於一具體實施例，該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的重量平均分子量是10~500kDa In a specific embodiment, the weight average molecular weight of the poly(sulfobetaine) or its copolymer is 10 to 500 kDa
根據本發明的第五實施例，本發明提供一種保養皮膚的美容方法，該保養皮膚的美容方法包含使用如上述第一實施例、第二實施例、第三實施例或第四實施例所述之皮膚保溼組合物在哺乳動物的皮膚表面上，所述之哺乳動物包括人類、貓或狗。 According to a fifth embodiment of the present invention, the present invention provides a skin care cosmetic method including using the first embodiment, the second embodiment, the third embodiment or the fourth embodiment as described above The skin moisturizing composition is on the skin surface of mammals including humans, cats or dogs.
根據本發明的第六實施例，本發明提供一種保養皮膚的美容方法，該保養皮膚的美容方法包含使用添加如上述第一實施例、第二實施例、第三實施例或第四實施例之皮膚保溼組合物的配方在哺乳動物的皮膚表面上，所述之哺乳動物包括人類、貓或狗。 According to a sixth embodiment of the present invention, the present invention provides a skin care cosmetic method, the skin care cosmetic method includes the use of the above-mentioned first embodiment, second embodiment, third embodiment or fourth embodiment The skin moisturizing composition is formulated on the skin surface of mammals including humans, cats or dogs.
於一具體實施例，所述之添加如上述第一實施例、第二實施例或第三實施例之皮膚保溼組合物的配方包含面膜液、精華液、乳液、乳霜、化妝水、卸妝水、膏狀物、凝膠或噴劑。 In a specific embodiment, the formula added with the skin moisturizing composition of the first embodiment, the second embodiment, or the third embodiment includes a mask liquid, essence, lotion, cream, lotion, makeup remover Water, paste, gel or spray.
於另一具體實施例，所述保養皮膚的美容方法，包含使用聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物在哺乳動物的皮膚表面上，所述之哺乳動物包括人類、貓或狗，該聚磺基甜菜鹼(poly(sulfobetaine))的重量平均分子量是10~500kDa。 In another specific embodiment, the skin care method includes using poly(sulfobetaine) or its copolymer on the skin surface of mammals, the mammals including humans, cats or For dogs, the weight average molecular weight of the poly(sulfobetaine) is 10 to 500 kDa.
較佳地，含有該聚磺基甜菜鹼(poly(sulfobetaine))或其共聚物的配方包含面膜液、精華液、乳液、乳霜、化妝水、卸妝水、膏狀物、凝膠或噴劑。 Preferably, the formula containing the poly(sulfobetaine) or its copolymer contains a mask liquid, essence, lotion, cream, lotion, makeup remover, cream, gel or spray .
以下實驗例係依據上述實施例所述之內容所進行的實驗，並據此做為本發明的詳細說明。 The following experimental examples are based on the experiments described in the foregoing embodiments, and are used as a detailed description of the present invention accordingly.
實驗例一：合成聚磺基甜菜鹼(poly(sulfobetaine))Experimental Example 1: Synthesis of poly(sulfobetaine)
在一反應器中放置1.04公斤的甲基丙烯酸二甲氨基乙酯(DMAEMA)、0.73公斤的1,3-丙磺酸內酯和10公斤的丙酮，在氮氣環境下進行開環反應，使用紅外光譜儀追蹤反應程度，當波數是在約2840~2850的甲基氨基(N-CH3)的特徵峰消失時，確認DMAEMA已反應完畢後，析出的固體是具有磺基甜菜鹼官能基的單體，使用新鮮丙酮清洗，經乾燥後得到純度大於95%的具有磺基甜菜鹼官能基的單體(SBMA)，產率是80~85%。 Place 1.04 kg of dimethylaminoethyl methacrylate (DMAEMA), 0.73 kg of 1,3-propane sultone and 10 kg of acetone in a reactor, and perform a ring-opening reaction under a nitrogen atmosphere, using infrared The spectrometer tracks the degree of reaction. When the characteristic peak of the methylamino group (N-CH3) with a wave number of about 2840~2850 disappears, it is confirmed that the solid precipitated is a monomer having a sulfobetaine functional group after the DMAEMA reaction has been completed. After washing with fresh acetone, the monomer with sulfobetaine functional group (SBMA) with a purity of more than 95% is obtained after drying, and the yield is 80-85%.
使用如表一所列的莫爾比例的單體(SBMA)和起始劑(AIBN)，升溫進行聚合反應，反應後所得到之聚磺基甜菜鹼的粗品經過清洗和乾燥後，得到精製的聚磺基甜菜鹼(poly(sulfobetaine))，並以GPC分析其分子量，結果如表二所示。 Use the monomer (SBMA) and initiator (AIBN) in the molar ratio as listed in Table 1 to carry out the polymerization reaction at elevated temperature. The crude polysulfobetaine obtained after the reaction is washed and dried to obtain refined Poly(sulfobetaine) and its molecular weight was analyzed by GPC. The results are shown in Table 2.
實驗例二：聚磺基甜菜鹼(poly(sulfobetaine))細胞毒性測試 Experimental Example 2: Cytotoxicity test of poly(sulfobetaine)
本測試是依據ISO 10993-5的標準步驟執行細胞毒性的測試，測試使用的細胞株是L929；測試結果顯示實驗例一所製備的聚磺基甜菜鹼的細胞毒性分級是0級，也就是無細胞毒性。 This test is based on the standard procedure of ISO 10993-5 to perform the cytotoxicity test. The cell line used is L929; the test results show that the polysulfobetaine prepared in Experimental Example 1 has a cytotoxicity rating of 0, that is, no Cytotoxicity.
實驗例三：聚磺基甜菜鹼(poly(sulfobetaine))的吸濕特性測試和比較Experimental Example 3: Hygroscopic property test and comparison of poly(sulfobetaine)
分別取5克的玻尿酸(HA)、聚乙二醇(分子量500Da；PEG500)和本發明之聚磺基甜菜鹼放置於相對濕度70%和溫度25℃的測試箱中，24小 時後取出秤重，計算個別的增加重量百分比，其增加重量百分比的計算方式是測試樣品經過設定的測試時間所增加的重量除以該測試樣品測試前的重量。經過測試，上述玻尿酸(HA)、聚乙二醇(分子量500Da；PEG500)和本發明之聚磺基甜菜鹼的增加重量百分比分別是1.6%、2.1%和11.3%，因此本發明之聚磺基甜菜鹼的捕捉環境中水分的能力明顯優於玻尿酸和聚乙二醇。 Take 5 grams of hyaluronic acid (HA), polyethylene glycol (molecular weight 500Da; PEG500) and the polysulfobetaine of the present invention in a test box with a relative humidity of 70% and a temperature of 25°C, and take out the weighing after 24 hours Calculate the individual weight increase percentage. The weight increase percentage is calculated by dividing the weight increase of the test sample after the set test time by the weight of the test sample before the test. After testing, the weight percentages of the above hyaluronic acid (HA), polyethylene glycol (molecular weight 500Da; PEG500) and the polysulfobetaine of the present invention are 1.6%, 2.1% and 11.3%, respectively, so the polysulfo group of the present invention Betaine's ability to capture moisture in the environment is significantly better than hyaluronic acid and polyethylene glycol.
實驗例四：配方吸溼效能測試之一Experimental Example 4: One of the tests of formula moisture absorption efficiency
首先配製如表三所示成分之精華液配方，以此配方作為控制組，然後分別再添加以控制組總重量計為14wt.%、3.5wt.%和0.875wt.%的聚磺基甜菜鹼進行測試，測試條件是在25℃相對濕度70%下放置30分鐘後，測量計算其增加重量百分比，並以此作為本實驗例所使用之配方捕捉環境中水分能力的依據。 First prepare the essence formula of the ingredients shown in Table 3, and use this formula as the control group, and then add the polysulfobetaine based on the total weight of the control group at 14wt.%, 3.5wt.%, and 0.875wt.%, respectively. The test was carried out under test conditions of 30 minutes at 25°C and 70% relative humidity. The weight percent increase was calculated and used as the basis for the formula used in this experiment to capture moisture in the environment.
測試結果顯示分別再添加以控制組總重量計為14wt.%、3.5wt.%和0.875wt.%的聚磺基甜菜鹼的配方相較於控制組的吸濕能力(增加重量百分比的增加倍率，以控制組為基準1)分別為4.2、2.2和1.5倍。據此確認本發明之聚磺基甜菜鹼具有優異的捕捉環境中水分的能力。 The test results show that the formulas of adding 14wt.%, 3.5wt.% and 0.875wt.% of polysulfobetaine based on the total weight of the control group are compared with the control group's hygroscopic capacity (increasing the percentage of increase in weight percentage) , Based on the control group 1) 4.2, 2.2 and 1.5 times respectively. Accordingly, it was confirmed that the polysulfobetaine of the present invention has an excellent ability to capture moisture in the environment.
實驗例五：配方吸溼效能測試之二Experimental example 5: The second part of the formula moisture absorption test
本實驗例是以實際應用在人體皮膚保溼的配方A作為控制組，配方A之組成如表四所示。上述之配方A分別加入肌肽、聚磺基甜菜鹼或肌肽和聚磺基甜菜鹼之組合物，然後在25℃相對濕度70%下放置30分鐘後量測計算其增加重量百分比，並以此作為配方捕捉環境中水分能力的依據。詳細的結果如表五所示。 In this experimental example, Formulation A, which is actually applied to moisturizing human skin, is used as the control group. The composition of Formulation A is shown in Table 4. The above formula A is added with carnosine, polysulfobetaine or a combination of carnosine and polysulfobetaine, and then placed at 25°C and 70% relative humidity for 30 minutes to measure and calculate the increase in weight percentage, and use this as The basis of the formula's ability to capture moisture in the environment. The detailed results are shown in Table 5.
1：配方A+0.83wt.%聚磺基甜菜鹼 1 : Formula A+0.83wt.% polysulfobetaine
2：配方A+0.83wt.%聚磺基甜菜鹼+0.5wt.%肌肽 2 : Formula A+0.83wt.% polysulfobetaine+0.5wt.% carnosine
3：配方A+0.5wt.%肌肽 3 : Formula A+0.5wt.% carnosine
4：增加重量百分比=[(測試時間(30分鐘)配方重量-初始時間(0分鐘)配方重量)/(初始時間(0分鐘)配方重量)]*100 4 : Increase weight percentage = [(test time (30 minutes) formula weight-initial time (0 minutes) formula weight)/(initial time (0 minutes) formula weight)]*100
根據表五之實驗數據，證實同時添加肌肽和聚磺基甜菜鹼之配方具有加乘效應的吸濕效果。 According to the experimental data in Table 5, it is confirmed that the formula of adding carnosine and polysulfobetaine at the same time has the hygroscopic effect of synergistic effect.
實驗例六：肌肽的鎖水效能測試Experiment 6: Carnosine's water-locking effectiveness test
本實驗例的測試條件是在相對濕度70%和溫度25℃的測試箱中進行。測試樣品A的組成是20wt.%的聚磺基甜菜鹼，其餘是水；測試樣品B的組成是15wt.%的聚磺基甜菜鹼和5wt.%的肌肽，其餘是水。在測試箱中放置30分鐘後，取出秤重，減少的重量是散失的水分，然後計算測試樣品中的水分散失率。其中測試樣品A的水分散失率是13%；測試樣品B 的水分散失率是6%。據此，明顯地同時包含聚磺基甜菜鹼和肌肽的保濕複方具有更優良的防止水分散失的能力，因此鎖水效能優於聚磺基甜菜鹼。 The test conditions of this experimental example were conducted in a test box with a relative humidity of 70% and a temperature of 25°C. The composition of the test sample A is 20wt.% polysulfobetaine, and the rest is water; the composition of the test sample B is 15wt.% polysulfobetaine and 5wt.% carnosine, and the rest is water. After being placed in the test box for 30 minutes, the scale is taken out, the reduced weight is the lost water, and then the water loss rate in the test sample is calculated. The water loss rate of test sample A is 13%; the water loss rate of test sample B is 6%. According to this, it is obvious that the moisturizing compound containing both polysulfobetaine and carnosine has a better ability to prevent water loss, so the water-locking effect is better than polysulfobetaine.
以上雖以特定實驗例說明本發明，但並不因此限定本發明之範圍，只要不脫離本發明之要旨，熟悉本技藝者瞭解在不脫離本發明的意圖及範圍下可進行各種變形或變更。此外，摘要部分和標題僅是用來輔助專利文件搜尋之用，並非用來限制本發明之權利範圍。 Although the present invention has been described with specific experimental examples above, it does not limit the scope of the present invention. As long as the gist of the present invention is not deviated, those skilled in the art understand that various modifications or changes can be made without departing from the intention and scope of the present invention. In addition, the abstract part and title are only used to assist the search of patent documents, not to limit the scope of the present invention.
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