TW201909743A - Oil-based concentrate, preparation method thereof and use thereof - Google Patents

Abstract

Disclosed are an oil-based concentrate, a preparation method therefor and the use thereof, the oil-based concentrate comprises the following components: a component a: at least one spirotetramat active substance which is solid at room temperature; a component b: at least one pyriproxyfen active substance which is solid at room temperature; a component c: at least one fatty acid ester with general formula R1-COO-R2 and/or R1-COO-R2-OOC-R1; a component d: at least one non-ionic surfactant and/or at least one anionic surfactant; and optionally a component e: one or at least two additives selected from an emulsifier, a defoaming agent, a preservative, an antioxidant, a colourant or an inert filling material; wherein the pyriproxyfen is dissolved in a molecular state in the component c, and the spirotetramat is suspended in a particle state in the component c. The oil-based concentrate prepared by the present invention can effectively resolve the problem of particle size increase of spirotetramat during storage, improve the stability of a preparation, and enhance the compounding effect and the bioavailability.

Description

Oil-based concentrated liquid, preparation method and application thereof

The invention belongs to the field of pesticides and relates to an oil-based concentrated liquid and a preparation method and application thereof.

Spirotetramat is a quaternary ketone acid compound developed by Bayer, and it is one of the modern insecticides that have two-way systemic conductance to date. The compound can move up and down throughout the plant to reach foliage and bark, thus controlling pests such as lettuce and cabbage on the inner leaves and fruit bark. This unique systemic ability protects new stems, leaves and roots from the growth of pest eggs and larvae. Another feature is the long duration of effect, which can provide effective control for up to 8 weeks.

Pyriproxyfen is a phenyl ether insect growth regulator that disturbs the growth of insects. It is a new type of insecticide with juvenile hormone analogs. It has systemic transfer activity, low toxicity, long duration, and is safe for crops. Low toxicity to fish and small impact on the ecological environment. It has a good control effect on Psylla, Bemisia tabaci, scale insects, Plutella xylostella, Spodoptera exigua, Spodoptera litura, Psylla Psylla and Thrips, etc. At the same time, this product has a good control effect on health pests such as flies and mosquito . It can inhibit mosquito and fly larva pupation and emergence. Mosquito and fly larvae basically die in the pupal stage when they contact the agent and cannot emerge. The duration of the drug is about 1 month, and it is easy to use and has no odor. It is a good mosquito and fly medicine.

At present, there is also a report on the formulation of Ciparam and Paliprofen. CN103283787A discloses the combination of Ciparam and Paliprofen. It also mentions that the formulation of the formulation includes wettable powder, water-dispersible granule Agents, suspensions, suspoemulsions, aqueous emulsions, microemulsions and microcapsule suspensions. The above dosage forms may encounter more or less difficulties in the actual preparation process. For example, because the melting point of the original drug of Beliperfin is 45-47 ° C, the preparation of wettable powders, water-dispersible granules or suspensions will not be suitable or cannot be processed because the melting point is too low, and the products prepared by the above formulations will be heated at 54 ° C Product failure due to melting of the original drug is not theoretically feasible. Although it is theoretically feasible to prepare the microcapsule suspension agent and the microcapsule suspension agent-suspending agent, because the microcapsule technology is complicated, it requires high processing equipment and high cost, so it is not used by the R & D personnel. Although the technology for preparing aqueous emulsions and microemulsions is relatively simple and mature, and the cost is low, this method is limited by the solubility and solubility of Cipamir and Paliprofen, and it is difficult to prepare high-content complex preparations, especially the sum of the contents. More than 30% of the formulations, and more or less use of environmentally unfriendly solvents were eliminated by the market.

Therefore, there is an urgent need on the market to develop excellent formulations that are environmentally friendly, stable in particle size and dosage form, simple in processing technology, and low in preparation cost.

In view of the shortcomings of the prior art, an object of the present invention is to provide an oil-based concentrated liquid, and a preparation method and application thereof.

To achieve this, the present invention adopts the following technical solutions: In one aspect, the present invention provides an oil-based concentrate, which includes the following components: a component: at least one kind of solid-state at room temperature Actives; component b: at least one belipofen active that is solid at room temperature; component c: at least one having the general formula R ₁ -COO-R ₂ and / or R ₁ -COO-R ₂ -OOC -R ₁ fatty acid ester, wherein R ₁ is an alkyl group and / or alkenyl group having 10 to 25 carbon atoms, and R ₂ is an alkyl group having 1 to 10 carbon atoms; d component: at least one non-ionic surface Active agent and / or at least one anionic surfactant; optionally e component: one or at least two additives selected from emulsifiers, defoamers, preservatives, antioxidants, colorants or inert filler materials; Ripfen is dissolved in the c component in a molecular state, and Cipafil is suspended in the c component in a particulate state.

In the present invention, by specifically selecting and matching the components of the oil-based concentrated liquid, especially the use of fatty acid ester components, the oil-based concentrated liquid can effectively control the problem of particle size growth during storage and greatly inhibit In order to increase the particle size of Cipaim, the stability of the formulation is improved, and the effect of Cipaim is improved. At the same time, Paliprofen can exist in the concentrated solution in a stable molecular state without crystal precipitation. The two actives do not affect each other, and maintain their respective states in the concentrate, which enhances the compounding effect.

In the present invention, the oil-based concentrated liquid compounded by Papex and Paliprofen does not contain a thickener (such as vegetable oil or mineral oil), but it can show excellent stability and improve its content. Contains Papex and the stability of the active ingredient formulation of belipurin.

In the present invention, the content of the individual components of the oil-based concentrate may be in a wide range.

Preferably, the oil-based concentrated liquid includes the following components in weight percentages: 0.1 to 30% of the a component, 0.1 to 30% of the b component, and 20 to 90% of the c component 1 to 30% of the d component and 0 to 40% of the e component;

In the present invention, the components of a specific amount of each other are matched to each other, so that the components of the oil-based concentrated liquid can achieve a better coordination state, effectively control the particle size increase problem during storage, and inhibit the suspension The particle size increases and the stability of the formulation is improved.

Preferably, the weight ratio of Ciparam to Paliprofen is 1: 10 ~ 10: 1, such as 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, 1: 6. , 1: 7, 1: 8, 1: 9, 1:10, 2: 1, 3: 1, 4: 1, 5: 1, 6: 1, 7: 1, 8: 1, 9: 1 or 10 : 1, preferably 1: 5 ~ 5: 1.

In the present invention, when the weight ratio of Cipafil and Paliprofen is 1: 10 ~ 10: 1, both of them can maintain more excellent activity, exist in the concentrated liquid in their respective states, and can Produce good compounding effect.

In the present invention, the oil-based concentrated solution can completely dissolve beliprefin, make beliprefin exist in a molecular state, and be able to suspend ciprofen particles. The c component is preferably a fatty acid ester of the general formula R ₁ -COO-R ₂ and / or R ₁ -COO-R ₂ -OOC-R ₁ . Wherein R ₁ is a straight or branched chain alkyl and / or alkenyl group having 10 to 25 carbon atoms, and R ₂ is a straight or branched chain alkyl group having 1 to 10 carbon atoms. The fatty acid ester conforming to the above structure is usually a C ₁₀ -C ₂₅ fatty acid ester of a mono- or diol of a C ₁ -C ₁₀ alkyl group and a fatty acid. The C ₁ -C ₁₀ alkyl mono- or diol may be ethanol, propanol, butanol, pentanol, hexanol, ethylene glycol, propylene glycol, butanediol, pentanediol or hexanediol Wait. The fatty acid is preferably a fatty acid having an even number of carbon atoms. For example, the fatty acid may be acetic acid, erucic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linoleic acid, or arachidic acid. Wait.

Preferably, R _{1 in} the c component is an alkyl and / or alkenyl group having 12 to 20 carbon atoms, for example, 12, 13, 14, 15, 16, 17, 18, 19 or 20 carbon atoms, Further preferred are alkyl and / or alkenyl groups having 12 to 18 carbon atoms; R ₂ is an alkyl group having 2 to 8 carbon atoms, such as 2, 3, 4, 5, 6, 7, or 8 carbons The atom is more preferably an alkyl group having 2 to 6 carbon atoms.

Preferably, the alkyl group is a linear alkyl group or a branched alkyl group.

Preferably, the component c is any one or a combination of at least two of ethyl oleate, butyl oleate, hexyl laurate, ethylene palmitate, or gluteryl linoleate.

In the present invention, the above-mentioned fatty acid ester or a combination thereof can regulate the stability of the oil-based concentrated liquid, and can effectively suppress the increase of the particle size of Ciproxil during storage.

Preferably, the non-ionic surfactant is selected from the group consisting of a copolymer of methacrylic acid and methacrylate, a polymer of fatty alcohol and ethylene oxide and / or propylene oxide, and ethylene oxide-propylene oxide Any one or at least two of block copolymer, fatty alcohol polyoxyethylene ether, alkyl glycoside, polyvinyl alcohol, polyvinyl pyrrolidone, alkyl ethoxylate, alkyl aryl ethoxylate or Tween The combination.

In the present invention, the non-ionic surfactant has the functions of dispersing, emulsifying and solubilizing.

Preferably, the anionic surfactant is selected from the group consisting of Borresperse NA, succinate sulfonate, naphthalene sulfonate formaldehyde polycondensate, sulfate of tristyrene ethoxylate, and tristyrene. Any one or a combination of at least two of ethoxylate phosphate or polycarboxylate.

In the present invention, the anionic surfactant has a clarifying and purifying effect.

In the present invention, the weight percentage of the component a in the oil-based concentrated solution is 0.1 to 30%, for example, 0.1%, 0.8%, 2%, 5%, 6.9%, 8.4%, 9.6%, 11%, 12.9 %, 15%, 17%, 18%, 19.5%, 21.2%, 25%, 27.5% or 30%, preferably 5-20%.

In the present invention, the weight percentage of component b in the oil-based concentrated solution is 0.1-30%, for example, 0.1%, 0.8%, 2%, 5%, 6.9%, 8.4%, 9.6%, 11%, 12.9 %, 15%, 17%, 18%, 19.5%, 21.2%, 25%, 27.5% or 30%, preferably 5-20%.

In the present invention, the weight percentage of the component c in the oil-based concentrated liquid is 20 to 90%, such as 20%, 21%, 25%, 32%, 40%, 50%, 55%, 60%, 68 %, 72%, 80%, 85% or 90%, preferably 30 ~ 80%;

In the present invention, by using any one or a combination of at least two of the esters in the c component, the addition of traditional vegetable oil can be avoided. When the content of the c component is preferably in the range of 30 to 80%, it can completely dissolve belipurfin and can also suspend and disperse the granules, which effectively avoids the risk of particle size growth and overcomes the problems encountered during storage. To the problem.

In the present invention, the weight percentage of the d component in the oil-based concentrated liquid is 1 to 30%, for example, 1%, 2%, 5%, 7%, 8.7%, 10.5%, 12%, 14%, 15 %, 16.4%, 17.5%, 19%, 21%, 23.2%, 25%, 28% or 30%, preferably 5-25%.

In the present invention, the weight percentage of the e component in the oil-based concentrated liquid is 0 to 40%, for example, 0%, 2%, 5%, 7%, 9.2%, 11%, 15%, 17%, 19 %, 20%, 23%, 25%, 27%, 30%, 34%, 37% or 40%, preferably 0-30%.

Preferably, the emulsifier is a reactant of alkylphenol with ethylene oxide and / or propylene oxide, ethoxylated nonylphenol, castor oil ethoxylate, polyalkoxylated alcohol Any one or a combination of at least one of a mixture of an alkyl calcium salt, a calcium alkyl benzene sulfonate, a sorbitan derivative, or a polyethylene oxide sorbitan fatty acid ester.

In the present invention, suitable defoamers include all substances commonly used for this purpose in agrochemical compositions. Preferably, the defoaming agent is an organosilicon defoamer, and a silicone defoamer is preferred.

In the present invention, suitable preservatives include all substances commonly used for this purpose in agrochemical compositions. Preferably, the preservative is selected from Proxel series and / or Nipacide series preservatives.

In the present invention, suitable antioxidants include all substances commonly used for this purpose in agrochemical compositions. Preferably, the antioxidant is 2,6-di-tert-butyl-4-methylphenol (BHT).

In the present invention, suitable colorants are all substances commonly used for this purpose in agrochemical compositions. Preferably, the colorant is any one or a combination of at least two of titanium dioxide, pearlescent powder, zinc oxide, blue pigment, or Pigment Red BBN (ie, light-fast red BBN).

In the present invention, suitable inert materials include all substances commonly used for this purpose in agrochemical compositions but which do not function as thickeners. Preferably, the inert filler material is any one or a combination of at least two of urea, silicate, sulfate or oxide.

Preferably, the oxide is a metal oxide and / or a non-metal oxide.

In another aspect, the present invention also provides a method for preparing the oil-based concentrated solution, the method for preparing is: combining the component a, component b, component c, component d, and optional component e Mix with stirring and grind to obtain the oil-based concentrated solution.

In the present invention, the oil-based concentrated solution is obtained by dissolving the b component in the c component completely by stirring, and then adding the a component, the d component, and the e component to the above-mentioned mixed liquid in any order to obtain suspension. And then thoroughly ground to obtain an oil-based concentrated solution.

Preferably, the grinding is performed at 10-50 ° C, such as 10 ° C, 15 ° C, 20 ° C, 25 ° C, 30 ° C, 35 ° C, 40 ° C, 45 ° C or 50 ° C, preferably 15-45 ° C. .

Preferably, the grinding is grinding to a solid particle size D90≤10 μm of the oil-based concentrated liquid, for example, 0.4 μm, 0.8 μm, 1 μm, 2 μm, 3 μm, 4 μm, 5 μm, 6 μm , 7 μm, 8 μm, 9 μm, or 10 μm, preferably D90 ≦ 5 μm.

In the present invention, the average size of the solid particles of the oil-based concentrated liquid is less than 10 μm. Under normal temperature storage and / or hot storage conditions, the particle size changes little, grows relatively slowly, and remains stable for a long time.

In the present invention, the preparation method has lower formulation cost, simple process, lower equipment requirements, and higher processing efficiency than existing microcapsule suspension agents or microcapsule suspension agent-suspension agent preparation methods.

In another aspect, the present invention provides a spray liquid comprising the oil-based concentrated liquid as described above.

In the present invention, the oil-based concentrated liquid of the present invention can be converted into a uniform spray liquid by dilution with water. The spray is applied by conventional methods, for example by spraying, injection, drip or pouring.

In the present invention, when the oil-based concentrated solution is diluted with water, there is no obvious emulsion layering, no destructive flocculation, and no crystallization phenomenon of belipfine, and it has very good physical and chemical properties. nature.

In another aspect, the present invention provides the use of an oil-based concentrated solution as described above for applying to a plant and / or its growing environment.

When the oil-based concentrated solution of the present invention is applied to a plant, the oil-based concentrated solution can be absorbed by the plant, enhance the penetration of the oil-based concentrated solution by the plant application site, improve the application efficiency, and enhance the bioavailability of Ciprofen and Paliprofen compound , Reduce its utilization.

In another aspect, the present invention provides the use of the oil-based concentrated liquid as described above for controlling insects.

The oil-based concentrated liquid of the present invention has high stability, can increase the activity of Ciparam and belipofen in its main active ingredients, and enhances the effect of controlling insects.

Preferably, the insects to be controlled are any one or at least two of Lepidoptera pests, Diptera pests, Hemiptera pests or Homoptera pests.

Lepidopteran pests, such as Earias insulana, Pieris rapae Linnaeus, Herpetogramma licarsisalis Walker, Spodoptera fugiperda, Spodoptera frugiperda, and Rachiplusia nu), Pseudoplusia includens, Sesamia inferens, Cnaphalocrocis medinalis Guenee, Maruca testulalis, Cirphisunipuncta, Tomato spot Tuta absoluta, Trichoplusia ni, Sesamianonagrioides, Trichoplusia ni, Anticarsia gemmatalis, Grapholitha molesta, potato Tuber moth (Phthorimaea operculella), wheat moth (Sitotroga cerealella), cotton spot moth (Earias vittella Fabricius), cotton brown band moth (Adoxophyes orana), cotton bollworm (Pectinophoragossypiella Saunders), cotton bollworm (Heliothis armigera), Alabama argi llacea, Lymantria monacha, Cydia pomonella, Pandemis heparana), Lobesia botrana, Sparganothis pilleriana, Endopiza vriteana Clemens, Scirpophaga incertulas, Spodopteraexigua Hübner, Spodoptera exigua (Spodopteraritura), Tobacco mealworm (Ephestia elutella), Tobacco bud moth (Heliothis virescens), Eupnotia aporema, Tineola bisselliella, Plodiainterpunctella, Ostrinianubilalis Hübner).

Diptera pests such as Aedes aegypti, Liriomyza brassicae, Sarcophaga haemorrhoidalis, Glossina morsi tans, Phorbia antiqua, Ceratitis capitata), cabbage fly (Delia radicum), melon fly (Dacuscucurbi tae), horsefly (Tabanus lineola), calliphora vricina, carrot stem fly (Psila rosae), orange fruit fly (Bactrocera dorsalis) , Culicoides furens, Aedes vexans, Rhagoletis mendax, Chrysomya spp., Chrysops discalis, Phorbia brassicae , Si todiplosis mosellana, Liriomyza trifolii, Rhagoletis pomonella, Hippelates, Bactrocera zonata, Pegomya hysocyami , Beet fly (Pegomya betae), Lucilia cuprina, Culexquinquefasciatus.

Hemiptera and Homoptera pests such as Sogatellafurcifera Horvrath, Trialeurodes vaporariorum, Ieryapurchasi Maskell, Iceryapurchasi, Aphis glycines, Rice fly Lice (Nilapar fly rata lugens), rice brown fly (Nilaparvratalugens), cabbage aphid (Brevicoryne brassicae), sweet potato whitefly (Bemisia tabaci), citrus psyllid (Diaphorina citri), black-tailed leafhopper (Nephotettix nigropictus), red Ceroplastesrubens, Aonidiella aurantii, Laodelphax striatellus, Aphis craccivrora Koch, Macrosiphum avenae, Apple aphid (Aphis pomi), Apple psyllid (Aphis pomi) Psylla mali), Brachycaudus persicae, Myzuspersicae Sulzer, Acyrthisiphon pisum Harris, Trialeurodes vaporariorum, Bemisia tabaci Gennadius, Leafhopper (Empoasca spp) .), Peregrinus maidis, Peregrinus maidisAshmead, Rhopalosiphum maidis, Sogatodes orizico la Muir).

The oil-based concentrated solution of the present invention is particularly suitable for controlling Bemisia tabaci, planthoppers, aphids, scale insects, thrips, rice leaf rollers, cockroaches, red spiders, Spodoptera litura, cabbage worm, diamondback moth, beet Spodoptera litura, yellow-striped beetle, or tea leafhopper. It is further particularly suitable for controlling whitefly and / or planthopper.

Compared with the prior art, the present invention has the following beneficial effects: (1) Compared with other existing dosage forms, the oil-based concentrated liquid of the present invention can effectively control the particle size increase during storage and solve the problem of suspension The problem of particle size increase, at the same time, Paliprofen can exist in the concentrated solution in a stable molecular state without crystal precipitation, and the two active substances do not affect each other, maintaining their respective states in the concentrate. The biological activity of both is maintained and exerted to a large extent. (2) The oil-based concentrated liquid of the present invention overcomes the constraints of conventional conditions, does not contain thickener vegetable oil or mineral oil, and has very good stability, and is particularly suitable for improving the active ingredients of Papex and Paliprofen. Formulation stability. (3) The oil-based concentrated liquid of the present invention has good physical and chemical properties. When the concentrated solution of the present invention is diluted with water, there is neither obvious emulsion delamination nor destructive flocculation, and the crystallization phenomenon of paliprofen is avoided. (4) The oil-based concentrated liquid of the present invention improves the bioactivity of Cipamir and Peripipen, reduces the use of both, enhances bioavailability, ultimately reduces costs, and has good control of Bemisia tabaci Effect, 25 days after high-concentration administration, the control effect on Bemisia tabaci adults can reach more than 95%, and the control effect on Bemisia tabaci nymphs can reach more than 85%. (5) The method for preparing the oil-based concentrated liquid of the present invention is simple in process, low in equipment requirements, high in processing efficiency, favorable for industrial-scale production, and greatly reduced production costs.

The technical solutions of the present invention will be further described below through specific embodiments. Those skilled in the art should understand that the embodiments are merely to help understand the present invention and should not be regarded as a specific limitation to the present invention.

The substances used in the following examples can be obtained by those skilled in the art through conventional pipelines.

Embodiment 1 In this embodiment, the oil-based concentrated liquid includes the following components:

The preparation method is as follows: adding belipurfin to ethyl oleate, and thoroughly stirring to completely dissolve belipurfin in ethyl oleate. Other materials are added to the above mixture in any order, and stirred to obtain a suspension. An oil-based concentrated solution with suspended particles D90 of less than 5 μm was obtained by rough grinding and fine grinding by a sand mill below 45 ° C.

Comparative Example 1 In this comparative example, the oil-based concentrated solution includes the following components: 10% Papex 10% Polyoxyethylene-sorbitan 15% Polyalkoxylated alcohol mixture 7 % Lignin sulfonate 3% Polydimethylsiloxane 1% 2,6-Di-tert-butyl-4-methylphenol 0.5% Vegetable oil (soy oil) 53.5%

The preparation method is as follows: the raw materials are added to the soybean oil in any order, and stirred to obtain a suspension. An oil suspension agent with a suspended particle D90 of less than 5 μm was obtained by rough grinding and fine grinding by a sand mill below 45 ° C.

Examples 2-7 and Comparative Examples 2-7 were prepared according to the same configuration method as above, and the components and amounts are shown in Table 1.

Table 1

Comparative Example 8

The preparation method is as follows: materials other than xanthan gum and a biocide are added to the water in any order and stirred to obtain a suspension. The coarse-grinding and fine-grinding of the sand mill were carried out below 45 ° C to obtain a water-based concentrated solution with suspended particles D90 of less than 5 μm. Then add the xanthan gum and the biocide in proportion, and stir until uniform to obtain an aqueous suspension.

The samples prepared in the above Examples 1-7 and the comparative examples 1-8 were stored for a long time, and tests were performed to compare the fluidity and particle size growth of the samples. The test method is: put the above 7 samples in a 54 ° C oven for 14 days and 28 days to observe the sample fluidity and test the particle size before and after storage with a Marvin particle size analyzer. The specific fluidity measurement results are shown in Table 2 and the particle size measurement results are shown in Table 3:

Table 2

The experiments in Table 2 show that the conventional water suspension and oil suspension agents, due to the lower melting point of belipfine, melted under the condition of hot storage at 54 ° C, and the molten crude drug oil droplets polymerized with each other, resulting in changes in the physical and chemical properties of the samples. The oil-based concentrated solution of the present invention, Ciprofen and Periperfin, solves this problem.

table 3

The experimental data in Table 3 show that the oil-based concentrated solution of Cipaim and Paliprofen of the present invention effectively controls the growth rate of the suspended particles in high temperature and long-term storage, and improves the stability of the oil-based concentrated solution.

Application Example 1 In this application example, the biological activity test was performed on the samples prepared in the above Examples 1-7 and Comparative Examples 1-8, as follows:

Test object: Bemisia tabaci

The above-mentioned examples 1-7 and comparative examples 1-8 were used for testing. The spray method was used in the tomato planting area. The pesticide was applied at the peak of the young instar, and the front and back were sprayed uniformly. Each treatment was repeated 3 times.

Adults were surveyed using 8 tomato plants per area and 2 large branches per plant. The number of adults on the large branches was investigated when the adults were not active in the early morning.

For the nymph survey, three leaves were collected from the top, middle, and bottom of five uncalibrated tomato plants for a total of 15 leaves, and the number of nymphs on these 15 leaves was recorded.

The number of adults and nymphs on the plants was investigated after 7, 14, and 25 days after the administration.

Effectiveness calculation method: Decline rate of insects = × 100% control effect = × 100%

The results of the control effect (control effect) on Bemisia tabaci adults are shown in Table 4:

Table 4

The oil-based concentrated liquid compounded by Cipaifen and Bailipufen of the present invention has excellent control effect on Bemisia tabaci adults. After 25 days of high dose administration, the control effect on Bemisia tabaci adults can reach more than 95%.

The control effect on Bemisia tabaci nymphs is shown in Table 5:

table 5

The oil-based concentrated solution of Cipaimex and belipipen of the present invention has excellent control effect on Bemisia tabaci nymphs. After 25 days of high-dose administration, the control effect on Bemisia tabaci nymphs can reach more than 85%. .

The applicant states that the present invention illustrates the oil-based concentrated solution of the present invention, its preparation method, and application through the above examples, but the present invention is not limited to the above examples, that is, it does not mean that the present invention must rely on the above examples to be implemented . Those skilled in the art should know that any improvement to the present invention, equivalent replacement of the raw materials of the products of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the scope of protection and disclosure of the present invention.

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Claims (10)

An oil-based concentrated liquid, characterized in that the oil-based concentrated liquid includes the following components: a component: at least one spirotetramat active substance which is solid at room temperature; b component: at least one room temperature The following is a solid pyriproxyfen active; c Component: at least one fatty acid ester having the general formula R1-COO-R2 and / or R1-COO-R2-OOC-R1, where R1 is An alkyl and / or alkenyl group of 25 carbon atoms, R2 is an alkyl group having 1 to 10 carbon atoms; d component: at least one non-ionic surfactant and / or at least one anionic surfactant; optionally e component: one or at least two additives selected from emulsifiers, defoamers, preservatives, antioxidants, colorants, or inert filler materials; where belipfen is dissolved in the c component in a molecular state, and Pixi is suspended in the c component in the form of particles. The oil-based concentrated liquid according to claim 1, wherein the oil-based concentrated liquid includes the following components in weight percentages: 0.1 to 30% of the component a, and 0.1 to 30% of the component b. 20% to 90% of the c component, 1 to 30% of the d component and 0 to 40% of the e component; The oil-based concentrate according to claim 1 or 2, characterized in that R1 in the c component is an alkyl group and / or an alkenyl group having 12 to 20 carbon atoms, preferably 12 to 18 carbon atoms Atomic alkyl and / or alkenyl; R2 is an alkyl having 2 to 8 carbon atoms, preferably an alkyl having 2 to 6 carbon atoms; preferably, the alkyl is a straight-chain alkyl or Branched alkyl. The oil-based concentrated liquid according to any one of claims 1-3, wherein the component c is ethyl oleate, butyl oleate, hexyl laurate, ethylene palmitate, or propylene Any one or a combination of at least two of glutaryl oleate. The oil-based concentrate according to any one of claims 1-4, wherein the non-ionic surfactant is selected from the group consisting of a copolymer of methacrylic acid and methacrylate, a fatty alcohol and ethylene oxide. And / or propylene oxide polymers, ethylene oxide-propylene oxide block copolymers, fatty alcohol polyoxyethylene ethers, polyvinyl alcohol, alkyl glycosides, polyvinyl pyrrolidone, alkyl ethoxylates, alkane Any one or a combination of at least two of an aryl ethoxylate or Tween; preferably, the anionic surfactant is selected from lignin sulfonate, succinate sulfonate, naphthalene sulfonate formaldehyde Any one or a combination of at least two of a polycondensate, a sulfate of tristyrene ethoxylate, a phosphate of tristyrene ethoxylate, or a polycarboxylate. The oil-based concentrated liquid according to any one of claims 1-5, characterized in that the weight percentage of component a in the oil-based concentrated liquid is 5 to 20%; preferably, the oil-based concentrated The weight percentage of component b in the liquid is 5 to 20%; preferably, the weight percentage of component c in the oil-based concentrated solution is 30 to 80%; preferably, the group d in the oil-based concentrated solution is The weight percentage of the cent is 2 to 20%; preferably, the weight percentage of the e component in the oil-based concentrated solution is 0 to 30%. The method for preparing an oil-based concentrated liquid according to any one of claims 1-6, wherein the method for preparing is: combining the a component, the b component, the c component, the d component, and Optional component e is stirred and mixed to obtain the oil-based concentrated liquid; preferably, the grinding is performed at 10-50 ° C, preferably 15-45 ° C; preferably, the grinding is grinding The particle diameter of the solid particles of the oil-based concentrated liquid is D90 ≦ 10 μm, preferably D90 ≦ 5 μm. A spray liquid, characterized in that the spray liquid comprises the oil-based concentrated liquid according to any one of claims 1-6. A use of the oil-based concentrated liquid according to any one of claims 1-6 to a plant and / or a growth environment thereof. A use of the oil-based concentrated liquid according to any one of claims 1 to 6 for controlling insects; preferably, the insects to be controlled are Lepidoptera pests, Diptera pests, Hemiptera pests or the same Any one or at least two of the winged pests; Preferably, the insects to be controlled are whitefly and / or planthopper.